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KDM3B Gene

protein-coding   GIFtS: 60
GCID: GC05P137688

Lysine (K)-Specific Demethylase 3B

(Previous names: chromosome 5 open reading frame 7, jumonji domain containing...)
(Previous symbols: C5orf7, JMJD1B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lysine (K)-Specific Demethylase 3B1 2     Chromosome 5 Open Reading Frame 71
C5orf71 2 3 5     5qNCA2
JMJD1B1 2 3 5     NET222
Jumonji Domain Containing 1B1 2     Lysine-Specific Demethylase 3B2
JmjC Domain-Containing Histone Demethylation Protein 2B2 3     EC 1.14.11.-3
Jumonji Domain-Containing Protein 1B2 3     JHDM2B3
Nuclear Protein 5qNCA2 3     EC 1.14.118
KIAA10823 5     

External Ids:    HGNC: 13371   Entrez Gene: 517802   Ensembl: ENSG000001207337   OMIM: 6093735   UniProtKB: Q7LBC63   

Export aliases for KDM3B gene to outside databases

Previous GC identifers: GC05P137717 GC05P132879


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KDM3B Gene:
KDM3B (lysine (K)-specific demethylase 3B) is a protein-coding gene. Diseases associated with KDM3B include acute promyelocytic leukemia, and non-hodgkin lymphoma. GO annotations related to this gene include dioxygenase activity. An important paralog of this gene is JMJD1C.

UniProtKB/Swiss-Prot: KDM3B_HUMAN, Q7LBC6
Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role
in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor
activity

Gene Wiki entry for KDM3B (JMJD1B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KDM3B gene promoter:
         ATF-2   STAT3   STAT5A   NF-kappaB   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KDM3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KDM3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31

KDM3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDM3B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P137688:  view genomic region     (about GC identifiers)

Start:
137,688,285 bp from pter      End:
137,772,717 bp from pter
Size:
84,433 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KDM3B_HUMAN, Q7LBC6 (See protein sequence)
Recommended Name: Lysine-specific demethylase 3B  
Size: 1761 amino acids; 191581 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Miscellaneous: Its gene is located in the 5q region of the genome which is deleted in del(5q) interstitial
deletion, a frequent deletion found in myeloid leukemias and myelodysplasias, suggesting that it may be a good
candidate for the del(5q) tumor suppressor gene
Sequence caution: Sequence=BAA83034.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for KDM3B:
4C8D (3D)    
Secondary accessions: A6H8X7 Q9BVH6 Q9BW93 Q9BZ52 Q9NYF4 Q9UPS0
Alternative splicing: 3 isoforms:  Q7LBC6-1   Q7LBC6-2   Q7LBC6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KDM3B: NX_Q7LBC6

Explore proteomics data for KDM3B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys204, Lys913, Lys926, Lys1249, Lys1272
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for KDM3B (Q7LBC6) (see all 15)
     KCRECRL  GVREMCD  ECWKQGQP  EDFVSPEH 


    See KDM3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057688.2  
    ENSEMBL proteins: 
     ENSP00000326563   ENSP00000425186   ENSP00000423012   ENSP00000378335   ENSP00000439462  

    KDM3B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for KDM3B

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    Cloud-Clone Corp. CLIAs for KDM3B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KDM: Chromatin-modifying enzymes / K-demethylases

    1 InterPro protein domain:
     IPR003347 JmjC_dom

    Graphical View of Domain Structure for InterPro Entry Q7LBC6

    ProtoNet protein and cluster: Q7LBC6

    1 Blocks protein domain: IPB003347 Transcription factor jumonji

    UniProtKB/Swiss-Prot: KDM3B_HUMAN, Q7LBC6
    Domain: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By
    similarity)
    Similarity: Belongs to the JHDM2 histone demethylase family
    Similarity: Contains 1 JmjC domain


    KDM3B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KDM3B_HUMAN, Q7LBC6
    Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role
    in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor
    activity

         Enzyme Numbers (IUBMB): EC 1.14.11.-1 EC 1.14.112

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
    GO:0051213dioxygenase activity IEA--
         
    KDM3B for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for KDM3B:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a  Synthetic lethal with Ras 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target KDM3B:
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    Block miRNA regulation of human, mouse, rat KDM3B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KDM3B (see all 23):
    hsa-miR-607 hsa-miR-4254 hsa-miR-429 hsa-miR-139-5p hsa-miR-1205 hsa-miR-570 hsa-miR-1304 hsa-miR-129-3p
    SwitchGear 3'UTR luciferase reporter plasmidKDM3B 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM3B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KDM3B_HUMAN, Q7LBC6: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1
    endoplasmic reticulum1
    extracellular1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    KDM3B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KDM3B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for KDM3B
        Chromatin Regulation / Acetylation




    KDM3B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KDM3B
    Interactions:

        Search GeneGlobe Interaction Network for KDM3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for KDM3B (Q7LBC62, 3 ENSP000003265634) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF512BQ96KM62, 3, ENSP000002171304MINT-60808 I2D: score=2 STRING: ENSP00000217130
    USP18Q9UMW83, ENSP000002157944I2D: score=2 STRING: ENSP00000215794
    ESRRAP114743, ENSP000000004424I2D: score=1 STRING: ENSP00000000442
    CREBBPENSP000002623674STRING: ENSP00000262367
    HIST3H3ENSP000003556574STRING: ENSP00000355657
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0016568chromatin modification IEA--

    KDM3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KDM3B

    3 Novoseek inferred chemical compound relationships for KDM3B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 67.9 20 16323267 (2), 18030324 (2), 11180958 (1), 1720570 (1) (see all 16)
    abscisic acid 48.1 3 16925600 (1)
    estrogen 3.71 1 8248217 (1)



    KDM3B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KDM3B gene: 
    NM_016604.3  

    Unigene Cluster for KDM3B:

    Lysine (K)-specific demethylase 3B
    Hs.483486  [show with all ESTs]
    Unigene Representative Sequence: NM_016604
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314358(uc003lcy.1) ENST00000510866(uc010jew.1) ENST00000512928
    ENST00000507996 ENST00000504095 ENST00000508386 ENST00000505756 ENST00000509468
    ENST00000394866(uc011cys.1) ENST00000542866
    miRNA
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    Block miRNA regulation of human, mouse, rat KDM3B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KDM3B (see all 23):
    hsa-miR-607 hsa-miR-4254 hsa-miR-429 hsa-miR-139-5p hsa-miR-1205 hsa-miR-570 hsa-miR-1304 hsa-miR-129-3p
    SwitchGear 3'UTR luciferase reporter plasmidKDM3B 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat KDM3B
      QuantiFast Probe-based Assays in human, mouse, rat KDM3B

    Additional mRNA sequence: 

    AB029005.2 AF251039.1 AF338242.1 AK025755.1 AK304371.1 BC000539.2 BC001202.1 BC073869.1 
    BC117692.1 BC117693.1 BC146788.1 

    11 DOTS entries:

    DT.87009767  DT.95190557  DT.92447513  DT.100795486  DT.440580  DT.100795487  DT.100795492  DT.40245180 
    DT.92447515  DT.40191866  DT.95352632 

    Selected AceView cDNA sequences (see all 262):

    BM968591 CR596928 BI917674 AL598864 CR615541 BM460083 BQ023995 BE018545 
    BX477892 F03931 BM457347 BE265035 CD671660 AI560465 CN483982 AA337372 
    AI219862 AI439064 AF338242 AL698902 BI768210 BF445534 AI199499 BC000539 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KDM3B (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^
    SP1:                                            -                                                           -                                               -   
    SP2:                                            -                                                           -                                               -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                        -                                                   
    SP5:                                                                                                                                                            

    ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
    SP1:  -                                             
    SP2:  -                                             
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for KDM3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KDM3B expression in normal human tissues (normalized intensities)      KDM3B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTTATTAA
    KDM3B Expression
    About this image


    KDM3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    KDM3B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KDM3B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.483486

    UniProtKB/Swiss-Prot: KDM3B_HUMAN, Q7LBC6
    Tissue specificity: Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KDM3B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kdm3b1 , 5 KDM3B lysine (K)-specific demethylase 3B1, 5 89.53(n)1
    93.36(a)1
      18 (18.73 cM)5
    2772501  NM_001081256.11  NP_001074725.11 
     347770085 
    chicken
    (Gallus gallus)
    Aves KDM3B1 lysine (K)-specific demethylase 3B 77.32(n)
    84.46(a)
      100859412  XM_004945064.1  XP_004945121.1 
    lizard
    (Anolis carolinensis)
    Reptilia KDM3B6
    lysine (K)-specific demethylase 3B
    80(a)
    1 ↔ 1
    2(146563872-146625306)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kdm3b1 lysine (K)-specific demethylase 3B 67.96(n)
    71.25(a)
      100135177  XM_002936848.2  XP_002936894.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa12c092 wufa12c09 78.17(n)   335041  57059800 
    fruit fly
    (Drosophila melanogaster)
    Insecta JHDM26
    JmjC domain-containing histone demethylase 2
    41(a)
    1 → many
    3R(5341731-5346660)


    ENSEMBL Gene Tree for KDM3B (if available)
    TreeFam Gene Tree for KDM3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KDM3B gene
    JMJD1C2  KDM3A2  HR2  
    3 SIMAP similar genes for KDM3B using alignment to 4 protein entries:     KDM3B_HUMAN (see all proteins):
    JMJD1B    KDM3A    JMJD1C

    KDM3B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KDM3B (see all 1482)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs728038421,2
    --137686335(+) GGTGCA/GCATAC 1 -- us2k10--------
    rs1407244111,2
    --137686452(+) TTTTTC/TCTTTA 1 -- us2k10--------
    rs1115194501,2
    F--137686654(+) GAGGGC/TAAGAG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs757337261,2
    F--137686743(+) ATGCAT/CTTCCC 1 -- us2k11Minor allele frequency- C:0.11WA 118
    rs782600521,2
    C,F--137687201(+) GACAGG/AAGATA 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1929401901,2
    --137687286(+) TCACTC/TTTAGA 1 -- us2k10--------
    rs1847577081,2
    --137687303(+) GTCATA/GGGTTA 1 -- us2k10--------
    rs1897392841,2
    --137687364(+) CATCCA/GTGAGA 1 -- us2k10--------
    rs1128426251,2
    C--137687608(+) ACTAAA/GAGAAC 1 -- us2k10--------
    rs1474392661,2
    C--137687770(+) TGGAA-/AGAGTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KDM3B (137688285 - 137772717 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KDM3B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664045CNV Deletion23128226
    esv1009373CNV Insertion20482838
    esv1007306CNV Insertion20482838
    esv1005958CNV Insertion20482838
    esv1001610CNV Gain20482838
    esv997516CNV Gain20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KDM3B
    DNA2.0 Custom Variant and Variant Library Synthesis for KDM3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609373    OMIM disorders: --

    12 diseases for KDM3B:    About MalaCards
    acute promyelocytic leukemia    non-hodgkin lymphoma    hodgkin's lymphoma    tonsillitis
    myeloid leukemia    leukemia    thyroiditis    breast cancer
    malaria    cerebritis    endotheliitis    prostatitis


    KDM3B for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for KDM3B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 11687974 (2)

    Genetic Association Database (GAD): KDM3B
    Human Genome Epidemiology (HuGE) Navigator: KDM3B (1 document)

    Export disorders for KDM3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KDM3B gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with KDM3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel nuclear protein, 5qNCA (LOC51780) is a candidate for the myeloid leukemia tumor suppressor gene on chromosome 5 band q31. (PubMed id 11687974)1, 2, 9 Hu Z.... Westbrook C.A. (Oncogene 2001)
    2. Identification and characterization of JMJD2 family genes in silico. (PubMed id 15138608)1, 3, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2004)
    3. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PubMed id 21102462)1, 4 Elks C.E....Murray A. (Nat. Genet. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. (PubMed id 16603237)1, 2 Yamane K.... Zhang Y. (Cell 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    9. cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins. (PubMed id 11087669)1, 2 Lai F....Le Beau M.M. (Genomics 2000)
    10. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51780 HGNC: 1337 AceView: JMJD1B Ensembl:ENSG00000120733 euGenes: HUgn51780
    ECgene: KDM3B H-InvDB: KDM3B

    (According to HUGE)
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    HUGE: KIAA1082

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KDM3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KDM3B gene:
    Search GeneIP for patents involving KDM3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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