KDM3A Gene
protein-coding GIFtS: 53
GCID: GC02P086667
|
|
lysine (K)-specific demethylase 3A(Previous names: jumonji domain containing 1, jumonji domain containing...)
(Previous symbols: JMJD1, JMJD1A)
| |
Aliases
for KDM3A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Lysine (K)-Specific Demethylase 3A1 2 | | Jumonji Domain Containing 1A1 2 | | JMJD1A1 2 3 5 | | JmjC Domain-Containing Histone Demethylation Protein 2A2 3 | | TSGA1 2 3 5 | | Jumonji Domain-Containing Protein 1A2 3 | | JMJD11 2 3 | | Jumonji C Domain-Containing Histone Demethylase 2A2 | | KIAA07421 3 5 | | Lysine-Specific Demethylase 3A2 | | JHDM2A2 3 5 | | Testis-Specific Protein A2 | | JHMD2A1 2 | | EC 1.14.11.-3 | | Jumonji Domain Containing 11 2 | | EC 1.14.118 |
Export aliases for KDM3A gene to outside databasesPrevious GC identifer: GC02P086521 |
Summaries
for KDM3A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KDM3A:
This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependenttranscriptional activation. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Apr2009)
UniProtKB/Swiss-Prot: KDM3A_HUMAN, Q9Y4C1Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role inhistone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference fordimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residuegenerates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating inrecruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation.Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required forpackaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genessuch as PPARA and UCP1
|
Genomic Views
for KDM3A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KDM3A gene promoter:
Egr-3 CUTL1 CBF-C CBF-A CBF-B STAT3 CP1A CP1C NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for KDM3A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDM3A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2KDM3A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P086667: view genomic region
(about GC identifiers)
Start:
|
86,667,770 bp from pter |
End:
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86,719,839 bp from pter |
Size:
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52,070 bases |
Orientation:
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plus strand |
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Proteins
for KDM3A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KDM3A_HUMAN, Q9Y4C1 (See
protein sequence)Recommended Name: Lysine-specific demethylase 3A Size: 1321 amino acids; 147341 Da
Cofactor: Binds 1 Fe(2+) ion per subunit
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Nuclear in round spermatids. Whenspermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in maturespermatozoa (By similarity)
Sequence caution: Sequence=BAA34462.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D6W5M3 Q53S72 Q68D47 Q68UT9 Q6N050 Q8IY08Explore the universe of human proteins at neXtProt for KDM3A: NX_Q9Y4C1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y4C1
4/26 DME Specific Peptides for KDM3A (Q9Y4C1) (see all 26)
KDM3A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001140160.1 NP_060903.2
ENSEMBL proteins: ENSP00000396561 ENSP00000386660 ENSP00000394691 ENSP00000386516 ENSP00000397660 ENSP00000323659 ENSP00000438324
Human Recombinant Protein Products for KDM3A:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
KDM3A for ontologies About GeneDecksing
KDM3A Antibody Products:
Assay Products for KDM3A: |
Protein
Domains /
Families
for KDM3A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KDM3A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y4C1ProtoNet protein and cluster: Q9Y4C1 UniProtKB/Swiss-Prot: KDM3A_HUMAN, Q9Y4C1Domain: The JmjC domain and the C6-type zinc-finger are required for the demethylation activityDomain: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity)Similarity: Belongs to the JHDM2 histone demethylase familySimilarity: Contains 1 JmjC domain |
Function
for KDM3A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: KDM3A_HUMAN, Q9Y4C1Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role inhistone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference fordimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residuegenerates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating inrecruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation.Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required forpackaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genessuch as PPARA and UCP1 Enzyme Numbers (IUBMB): EC 1.14.11.-1 EC 1.14.112
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
IEA | -- | | GO:0001047 | core promoter binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0005506 | iron ion binding |
IMP | 16603237 | | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
IEA | -- |
KDM3A for ontologies About GeneDecksing
Phenotypes:
10 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Kdm3a):
KDM3A for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for KDM3A: Kdm3atm1Jxu Kdm3atm1.1Jsak Kdm3atm1.1Yzha
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KDM3A (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KDM3A (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): KDM3A (NM_018433) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KDM3A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDM3A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM3A |
|
Pathways & Interactions
for KDM3A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Coregulation of Androgen receptor activity | |
1  BioSystems Pathway for KDM3A
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KDM3A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/15 Interacting proteins for KDM3A (Q9Y4C13 ENSP000003236594) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
KDM3A for ontologies About GeneDecksing
|
Drugs & Compounds
for KDM3A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KDM3A
Search CenterWatch for drugs/clinical trials and news about KDM3A
|
Transcripts
for KDM3A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KDM3A gene (2 alternative transcripts): NM_001146688.1 NM_018433.5 Unigene Cluster for KDM3A: Lysine (K)-specific demethylase 3A Hs.557425 [show with all ESTs]Unigene Representative Sequence: NM_01843316 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000452034 ENST00000409556 ENST00000441719 ENST00000409064(uc010ytj.2 uc010ytk.2)
ENST00000427678 ENST00000498528 ENST00000466058 ENST00000463013 ENST00000488971
ENST00000485171 ENST00000462197 ENST00000491383 ENST00000470160 ENST00000483866
ENST00000312912(uc002sri.4) ENST00000542128
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KDM3A (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KDM3A (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): KDM3A (NM_018433) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KDM3A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDM3A |
Additional cDNA sequence: AB018285.2 AK074314.1 AK304276.1 BC038297.2 BX640698.1 BX647271.1 BX647752.1 BX648841.1 CR749581.1 17 DOTS entries: DT.95159942 DT.449251 DT.91760885 DT.99948816 DT.40288610 DT.100787360 DT.120934032 DT.97846421 DT.95182295 DT.40112642 DT.75157816 DT.95159941 DT.95330753 DT.95102898 DT.95255426 DT.95303371 DT.99945375 24/210 AceView cDNA sequences (see all 210): CK429407 BC038297 AI492066 BQ020341 BX118305 BM669172 AA480252 BM720959 AA360794 BX647752 BM678585 CA428987 BM701240 BU684149 CD674187 AA588202 AL832150 AI911797 AK074314 BM693587 NM_018433 CA428583 CA432703 AW511889
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for KDM3A (see all 10) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | · | 27c | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KDM3A
|
Expression
for KDM3A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KDM3A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATCCTTAAA
About this image
See KDM3A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KDM3A
SOURCE GeneReport for Unigene cluster: Hs.557425
SABiosciences Custom PCR Arrays for KDM3A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KDM3A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KDM3A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KDM3A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KDM3A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM3A |
Orthologs
for KDM3A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KDM3A gene from 5/21 species (see all 21) About this table
ENSEMBL Gene Tree for KDM3A (if available)
TreeFam Gene Tree for KDM3A (if available) |
Paralogs
for KDM3A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KDM3A gene
- JMJD1C2 KDM3B2 HR2
4 SIMAP similar genes for KDM3A using alignment to 5 protein entries: KDM3A_HUMAN (see all proteins):JMJD1A JMJD1B KDM3B JMJD1C
KDM3A for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for KDM3A
PGOHUM00000240458
|
Genomic Variants
for KDM3A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KDM3A (86667770 - 86719839 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KDM3A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KDM3A |
|
Disorders
/ Diseases
for KDM3A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KDM3A for disorders About GeneDecksing
OMIM gene information: 611512
OMIM disorders: --
10  diseases for KDM3A: About MalaCardsrenal cell carcinoma azoospermia obesity, resistance to obesity
nasopharyngitis colorectal cancer prostate cancer hypoxia
prostatitis carcinoma
Human Genome Epidemiology (HuGE) Navigator: KDM3A (1 document)
Export disorders for KDM3A gene to outside databases
|
Publications
for KDM3A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KDM3A gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with KDM3A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
- JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. (PubMed id 16603237)1, 2 Yamane K.... Zhang Y. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- Dynamic change of chromatin conformation in response t o hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction o f hypoxia-inducible factor 1 and KDM3A. (PubMed id 22645302)1 Mimura I....Wada Y. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Ascorbate antagonizes nickel ion to regulate JMJD1A ex pression in kidney cancer cells. (PubMed id 22318714)1 Guo X....Cai Z. (2012)
- The JmjC domain-containing histone demethylase KDM3A i s a positive regulator of the G1/S transition in cancer cells via transcriptiona l regulation of the HOXA1 gene. (PubMed id 22020899)1 Cho H.S....Hamamoto R. (2012)
- Role of the hypoxia-related gene, JMJD1A, in hepatocel lular carcinoma: clinical impact on recurrence after hepatic resection. (PubMed id 21607773)1 Yamada D....Nagano H. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Upregulation of MiR-155 in nasopharyngeal carcinoma i s partly driven by LMP1 and LMP2A and downregulates a negative prognostic marke r JMJD1A. (PubMed id 21541331)1 Du Z.M....Ernberg I. (2011)
|
External Searches for KDM3A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KDM3A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KDM3A gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KDM3A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KDM3A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KDM3A gene:
Search GeneIP for patents involving KDM3A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KDM3A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for KDM3A | | OriGene shRNA RFP for KDM3A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KDM3A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KDM3A | | | OriGene Protein Over-expression Lysate for KDM3A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KDM3A | | OriGene 3'-UTR Clone for KDM3A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KDM3A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KDM3A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for KDM3A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KDM3A | | OriGene Custom Protein Services for KDM3A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KDM3A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KDM3A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDM3A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KDM3A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KDM3A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KDM3A |
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| | | | Search Tocris compounds for KDM3A |
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 | | | KDM3A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM3A |
|  |  |  |  | | | | ThermoFisher Antibody for KDM3A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDM3A |
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