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KDM3A Gene

protein-coding   GIFtS: 57
GCID: GC02P086667

Lysine (K)-Specific Demethylase 3A

(Previous names: jumonji domain containing 1, jumonji domain containing 1A)
(Previous symbols: JMJD1, JMJD1A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lysine (K)-Specific Demethylase 3A1 2     JmjC Domain-Containing Histone Demethylation Protein 2A2 3
JMJD1A1 2 3 5     Jumonji Domain-Containing Protein 1A2 3
JMJD11 2 3     KIAA07423 5
JHDM2A2 3 5     JHMD2A2
TSGA2 3 5     Lysine-Specific Demethylase 3A2
Jumonji Domain Containing 11 2     Testis-Specific Protein A2
Jumonji Domain Containing 1A1 2     EC 1.14.11.-3
Jumonji C Domain-Containing Histone Demethylase 2A1 2     EC 1.14.118

External Ids:    HGNC: 208151   Entrez Gene: 558182   Ensembl: ENSG000001155487   OMIM: 6115125   UniProtKB: Q9Y4C13   

Export aliases for KDM3A gene to outside databases

Previous GC identifer: GC02P086521


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KDM3A Gene:
This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent
transcriptional activation. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Apr 2009)

GeneCards Summary for KDM3A Gene:
KDM3A (lysine (K)-specific demethylase 3A) is a protein-coding gene. Diseases associated with KDM3A include kidney cancer, and azoospermia. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KDM3B.

UniProtKB/Swiss-Prot: KDM3A_HUMAN, Q9Y4C1
Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role
in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for
dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue
generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating
in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional
activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are
required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of
metabolic genes such as PPARA and UCP1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KDM3A gene promoter:
         Egr-3   CUTL1   CBF-C   CBF-A   CBF-B   STAT3   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKDM3A promoter sequence
   Search Chromatin IP Primers for KDM3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KDM3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

KDM3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDM3A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P086667:  view genomic region     (about GC identifiers)

Start:
86,667,770 bp from pter      End:
86,719,839 bp from pter
Size:
52,070 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KDM3A_HUMAN, Q9Y4C1 (See protein sequence)
Recommended Name: Lysine-specific demethylase 3A  
Size: 1321 amino acids; 147341 Da
Cofactor: Binds 1 Fe(2+) ion per subunit
Sequence caution: Sequence=BAA34462.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D6W5M3 Q53S72 Q68D47 Q68UT9 Q6N050 Q8IY08

Explore the universe of human proteins at neXtProt for KDM3A: NX_Q9Y4C1

Explore proteomics data for KDM3A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys851, Lys895, Lys905, Lys918
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for KDM3A (Q9Y4C1) (see all 26)
     KCRECRL  GVREMCD  SPVFCRF  DIVHSVR 


    See KDM3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001140160.1  NP_060903.2  

    ENSEMBL proteins: 
     ENSP00000396561   ENSP00000386660   ENSP00000394691   ENSP00000386516   ENSP00000397660  
     ENSP00000323659   ENSP00000438324  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KDM: Chromatin-modifying enzymes / K-demethylases

    1 InterPro protein domain:
     IPR003347 JmjC_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y4C1

    ProtoNet protein and cluster: Q9Y4C1

    UniProtKB/Swiss-Prot: KDM3A_HUMAN, Q9Y4C1
    Domain: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity
    Domain: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By
    similarity)
    Similarity: Belongs to the JHDM2 histone demethylase family
    Similarity: Contains 1 JmjC domain


    KDM3A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KDM3A_HUMAN, Q9Y4C1
    Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role
    in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for
    dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue
    generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating
    in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional
    activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are
    required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of
    metabolic genes such as PPARA and UCP1

         Enzyme Numbers (IUBMB): EC 1.14.11.-1 EC 1.14.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0001047core promoter binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005506iron ion binding IMP16603237
    GO:0005515protein binding ----
         
    KDM3A for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Kdm3a):
     adipose tissue  behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body 
     homeostasis/metabolism  liver/biliary system  muscle  no phenotypic analysis  reproductive system 

    KDM3A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KDM3A: Kdm3atm1.1Jsak Kdm3atm1Jxu Kdm3atm1.1Yzha

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KDM3A
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    Selected qRT-PCR Assays for microRNAs that regulate KDM3A (see all 9):
    hsa-miR-30c hsa-miR-22 hsa-miR-3607-3p hsa-let-7a-2* hsa-miR-30d hsa-miR-30a hsa-let-7g* hsa-miR-30b
    SwitchGear 3'UTR luciferase reporter plasmidKDM3A 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KDM3A_HUMAN, Q9Y4C1: Cytoplasm (By similarity). Nucleus (By similarity). Note=Nuclear in round spermatids. When
    spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature
    spermatozoa (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16603237
    GO:0005737cytoplasm IEA--

    KDM3A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KDM3A About    
    See pathways by source

    SuperPathContained pathways About
    1Coregulation of Androgen receptor activity
    Coregulation of Androgen receptor activity


    1 BioSystems Pathway for KDM3A
        Coregulation of Androgen receptor activity


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KDM3A
    Interactions:

        Search GeneGlobe Interaction Network for KDM3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for KDM3A (Q9Y4C13 ENSP000003236594) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MKL1Q969V63, ENSP000003478474I2D: score=1 STRING: ENSP00000347847
    MKL2Q9ULH73, ENSP000003390864I2D: score=1 STRING: ENSP00000339086
    SETQ011053, ENSP000003617774I2D: score=1 STRING: ENSP00000361777
    TCEAL1Q151703, ENSP000003617074I2D: score=2 STRING: ENSP00000361707
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0007283spermatogenesis ----
    GO:0007290spermatid nucleus elongation IEA--
    GO:0009755hormone-mediated signaling pathway IDA16603237
    GO:0030521androgen receptor signaling pathway IDA16603237

    KDM3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KDM3A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KDM3A gene (2 alternative transcripts): 
    NM_001146688.1  NM_018433.5  

    Unigene Cluster for KDM3A:

    Lysine (K)-specific demethylase 3A
    Hs.557425  [show with all ESTs]
    Unigene Representative Sequence: NM_018433
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452034 ENST00000409556 ENST00000441719 ENST00000409064(uc010ytj.2 uc010ytk.2)
    ENST00000427678 ENST00000498528 ENST00000466058 ENST00000463013 ENST00000488971
    ENST00000485171 ENST00000462197 ENST00000491383 ENST00000470160 ENST00000483866
    ENST00000312912(uc002sri.4) ENST00000542128
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate KDM3A (see all 9):
    hsa-miR-30c hsa-miR-22 hsa-miR-3607-3p hsa-let-7a-2* hsa-miR-30d hsa-miR-30a hsa-let-7g* hsa-miR-30b
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      QuantiFast Probe-based Assays in human, mouse, rat KDM3A

    Additional mRNA sequence: 

    AB018285.2 AK074314.1 AK304276.1 BC038297.2 BX640698.1 BX647271.1 BX647752.1 BX648841.1 
    CR749581.1 

    17 DOTS entries:

    DT.95159942  DT.449251  DT.91760885  DT.99948816  DT.40288610  DT.100787360  DT.120934032  DT.97846421 
    DT.95182295  DT.40112642  DT.75157816  DT.95159941  DT.95330753  DT.95102898  DT.95255426  DT.95303371 
    DT.99945375 

    Selected AceView cDNA sequences (see all 210):

    BQ424139 AA723837 AA121906 AB018285 AA894419 BX647271 AI143634 BU622316 
    AI468106 BM699317 AW969321 BU679010 CA432703 CA428583 AI911797 AK074314 
    NM_018433 AL832150 BM693587 AA588202 CD674187 BU684149 BM701240 CA428987 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KDM3A (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                          -                                                           -                       -                       -                     
    SP2:                          -                                                           -                       -                       -                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28 ^ 29 ^ 30 ^ 31
    SP1:                                      -     -                                 
    SP2:                                      -     -                                 
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for KDM3A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KDM3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCCTTAAA
    KDM3A Expression
    About this image

    KDM3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KDM3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.557425
        Custom PCR Arrays for KDM3A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM3A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KDM3A gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kdm3a1 , 5 lysine (K)-specific demethylase 3A1, 5 89.23(n)1
    91.74(a)1
      6 (32.18 cM)5
    1042631  NM_173001.31  NP_766589.11 
     715889745 
    chicken
    (Gallus gallus)
    Aves KDM3A1 lysine (K)-specific demethylase 3A 71.52(n)
    71.26(a)
      422917  NM_001012891.1  NP_001012909.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.28182 Xenopus laevis transcribed sequence with moderate similarity more 75.96(n)    BG578246.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta JHDM26
    JmjC domain-containing histone demethylase 2
    39(a)
    1 → many
    3R(5341731-5346660)


    ENSEMBL Gene Tree for KDM3A (if available)
    TreeFam Gene Tree for KDM3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KDM3A gene
    KDM3B2  JMJD1C2  HR2  
    4 SIMAP similar genes for KDM3A using alignment to 5 protein entries:     KDM3A_HUMAN (see all proteins):
    JMJD1A    JMJD1B    KDM3B    JMJD1C

    KDM3A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KDM3A
    PGOHUM00000240458


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KDM3A (see all 1181)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359404
    A breast cancer sample4--see VAR_0359402 D H mis40--------
    rs1939210561,2
    Cuntested186709231(+) GTATG-/TGTT  
            
    TGTTT
    2 -- int10--------
    rs346332681,2
    C,F--86666301(+) CTTAAG/TATCAC 1 -- us2k15Minor allele frequency- T:0.16NA WA CSA 244
    rs1874839431,2
    --86666309(+) CACAAA/GTGTTC 1 -- us2k10--------
    rs75980581,2
    C,A,H--86666355(+) ATATAT/CGATTT 1 -- us2k112Minor allele frequency- C:0.17NA WA CSA EA 376
    rs65476881,2
    C,H--86666365(+) TTTCTC/TTTTTA 1 -- us2k1 trp312Minor allele frequency- T:0.16NA WA CSA EA 376
    rs65476891,2
    C,H--86666459(+) TAAAAG/AAAATG 1 -- us2k18Minor allele frequency- A:0.17NA WA EA 370
    rs65476901,2
    C,H--86666461(+) AAAAAT/AATGCT 1 -- us2k18Minor allele frequency- A:0.17NA WA EA 370
    rs1163042451,2
    F--86666675(+) TCAGGT/CTCAAT 2 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1433937611,2
    C--86666753(+) CCCTTA/CTATTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for KDM3A (86667770 - 86719839 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for KDM3A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2813CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KDM3A
    DNA2.0 Custom Variant and Variant Library Synthesis for KDM3A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611512    OMIM disorders: --

    14 diseases for KDM3A:    
    About MalaCards
    kidney cancer    azoospermia    hypoxia    nasopharyngitis
    kaposi's sarcoma    breast and colorectal cancer    renal cell carcinoma    obesity
    colorectal cancer    sarcoma    hepatocellular carcinoma    prostate cancer
    prostatitis    hepatitis


    KDM3A for disorders           About GeneDecksing

    Genetic Association Database (GAD): KDM3A
    Human Genome Epidemiology (HuGE) Navigator: KDM3A (1 document)

    Export disorders for KDM3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KDM3A gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with KDM3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (Hum. Reprod. 2010)
    3. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. (PubMed id 16603237)1, 2 Yamane K.... Zhang Y. (Cell 2006)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. Control of histone H3 lysine 9 (H3K9) methylation state via cooperative two-step demethylation by Jumonji domain containing 1A (JMJD1A) homodimer. (PubMed id 24214985)1 Goda S....Aburatani H. (J. Biol. Chem. 2013)
    6. Nitric oxide modifies global histone methylation by inhibiting Jumonji C domain-containing demethylases. (PubMed id 23546878)1 Hickok J.R....Thomas D.D. (J. Biol. Chem. 2013)
    7. The histone demethylase JMJD1A regulates adrenomedullin-mediated cell proliferation in hepatocellular carcinoma under hypoxia. (PubMed id 23583388)1 Park S.J....Heo K. (Biochem. Biophys. Res. Commun. 2013)
    8. Aberrant histone modification in peripheral blood B cells from patients with systemic sclerosis. (PubMed id 23891737)1 Wang Y....Xiao R. (Clin. Immunol. 2013)
    9. Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen regulates the KSHV epigenome by association with the histone demethylase KDM3A. (PubMed id 23576503)1 Kim K.Y....Izumiya Y. (J. Virol. 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55818 HGNC: 20815 AceView: JMJD1A Ensembl:ENSG00000115548 euGenes: HUgn55818
    ECgene: KDM3A H-InvDB: KDM3A

    (According to HUGE)
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    HUGE: KIAA0742

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KDM3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KDM3A gene:
    Search GeneIP for patents involving KDM3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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