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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KDM2B Gene

protein-coding GIFtS: 55
GCID: GC12M121866

lysine (K)-specific demethylase 2B

(Previous name: F-box and leucine-rich repeat protein 10 )
(Previous symbol: FBXL10)

Explore 2 diseases affiliated with
KDM2B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lysine (K)-Specific Demethylase 2B¹ ²		[Histone-H3]-Lysine-36 Demethylase 1B² ³
CXXC2¹ ² ³		CXXC-Type Zinc Finger Protein 2² ³
FBXL10¹ ² ³		F-Box Protein FBL10² ³
JHDM1B¹ ² ³		F-Box/LRR-Repeat Protein 10² ³
PCCX2¹ ² ³		EC 1.14.11.27³ ⁸
F-Box And Leucine-Rich Repeat Protein 10¹ ² ³		JEMMA (Jumonji Domain, EMSY-Interactor, Methyltransferase Motif) Protein²
Fbl10¹ ²		Jumonji C Domain-Containing Histone Demethylase 1B²
JmjC Domain-Containing Histone Demethylation Protein 1B² ³		Lysine-Specific Demethylase 2B²
Jumonji Domain-Containing EMSY-Interactor Methyltransferase Motif Protein² ³		FBL10³
Protein-Containing CXXC Domain 2² ³		Protein JEMMA³

External Ids:	HGNC: 13610¹	Entrez Gene: 84678²	Ensembl: ENSG00000089094⁷	OMIM: 609078⁵	UniProtKB: Q8NHM5³

Export aliases for KDM2B gene to outside databases

Previous GC identifers: GC12M120351 GC12M118876

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KDM2B:

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,

the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs

(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3

classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different

protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls

class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of

some variants has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KDM2B_HUMAN, Q8NHM5

Function: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in

histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has

weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal

RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also

serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009775.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KDM2B gene promoter:
AP-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KDM2B promoter sequence

Search SABiosciences Chromatin IP Primers for KDM2B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDM2B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31

KDM2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDM2B gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M121866: view genomic region (about GC identifiers)

Start:	121,866,899 bp from pter	End:	122,018,920 bp from pter
Size:	152,022 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KDM2B_HUMAN, Q8NHM5 (See protein sequence)

Recommended Name: Lysine-specific demethylase 2B

Size: 1336 amino acids; 152615 Da

Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)

Subunit: Directly interacts with SKP1 and CUL1 (By similarity)

Subcellular location: Nucleus, nucleolus

Sequence caution: Sequence=AAH08735.2; Type=Erroneous initiation; Sequence=BAB55112.1; Type=Erroneous initiation;

Sequence=BAB55301.1; Type=Erroneous initiation; Sequence=BAC11159.1; Type=Erroneous initiation;

Secondary accessions: A8MRS1 Q8NCI2 Q96HC7 Q96SL0 Q96T03 Q9NS96 Q9UF75

Alternative splicing: 4 isoforms: Q8NHM5-1 Q8NHM5-2 Q8NHM5-3 Q8NHM5-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KDM2B: NX_Q8NHM5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NHM5

4/11 DME Specific Peptides for KDM2B (Q8NHM5) (see all 11)

IHAVYTP

TDFHIDF

GLGIKMP

GTSVWYH

KDM2B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001005366.1 NP_115979.3

ENSEMBL proteins:

ENSP00000437821 ENSP00000366269 ENSP00000366271 ENSP00000438138 ENSP00000398279

ENSP00000444846 ENSP00000445102 ENSP00000437497 ENSP00000443052 ENSP00000440942

ENSP00000442293 ENSP00000440373 ENSP00000445741 ENSP00000445196

Human Recombinant Protein Products:

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	Uscn Proteins for KDM2B

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	10799292
GO:0005730	nucleolus	IEA	--
GO:0031519	colocalizes with PcG protein complex	IDA	16943429

KDM2B for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for KDM2B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KDM2B for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR001965 Znf_PHD

IPR002857 Znf_CXXC

IPR001810 F-box_dom_cyclin-like

IPR003347 JmjC_dom

IPR011011 Znf_FYVE_PHD

Graphical View of Domain Structure for InterPro Entry Q8NHM5

ProtoNet protein and cluster: Q8NHM5

2 Blocks protein families:

IPB002857 Zn-finger

IPB003347 Transcription factor jumonji

UniProtKB/Swiss-Prot: KDM2B_HUMAN, Q8NHM5

Domain: The JmjC domain mediates demethylation activity (By similarity). It is also required for repression of

ribosomal RNA genes

Similarity: Belongs to the JHDM1 histone demethylase family

Similarity: Contains 1 CXXC-type zinc finger

Similarity: Contains 1 F-box domain

Similarity: Contains 1 JmjC domain

Similarity: Contains 7 LRR (leucine-rich) repeats

Similarity: Contains 1 PHD-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KDM2B_HUMAN, Q8NHM5

Function: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in

histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has

weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal

RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also

serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex

Catalytic activity: Protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) = protein N(6)-methyl-L-lysine +

succinate + formaldehyde + CO(2)

Catalytic activity: Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) = protein L-lysine + succinate + formaldehyde

+ CO(2)

Enzyme Number (IUBMB): EC 1.14.11.27¹ ²

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM2B

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	NAS	10799292
GO:0005515	protein binding	IPI	16943429
GO:0008270	zinc ion binding	NAS	--
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	--
GO:0019843	rRNA binding	IEA	--

KDM2B for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for KDM2B:

Decreased nuclei size in G2M

Increased cell death HMECs cel

Synthetic lethal with Ras

Upregulation of Wnt/beta-caten

Animal Models:
9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Kdm2b):

cardiovascular system	cellular	embryogenesis	growth/size	limbs/digits/tail
mortality/aging	nervous system	reproductive system	vision/eye

KDM2B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KDM2B

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/27 Interacting proteins for KDM2B (Q8NHM5^{1, 3} ENSP00000366271⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BCOR	Q6W2J9¹^,³, ENSP00000367705⁴	EBI-3955564,EBI-950027 I2D: score=3 STRING: ENSP00000367705
RNF2	Q99496³, ENSP00000356480⁴	I2D: score=2 STRING: ENSP00000356480
EZH2	Q15910³, ENSP00000320147⁴	I2D: score=1 STRING: ENSP00000320147
SKP1	P63208³, ENSP00000231487⁴	I2D: score=3 STRING: ENSP00000231487
PCGF1	Q9BSM1³, ENSP00000233630⁴	I2D: score=2 STRING: ENSP00000233630

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	ISS	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0007283	spermatogenesis	ISS	--
GO:0016577	histone demethylation	TAS	--
GO:0021555	midbrain-hindbrain boundary morphogenesis	ISS	--

KDM2B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KDM2B

2 HMDB Compounds for KDM2B About this table

Compound	Synonyms	CAS #	PubMed Ids
Formaldehyde	Aldeide formica (see all 16)	50-00-0	--
L-Lysine	(+)-S-Lysine (see all 25)	56-87-1	--

Search CenterWatch for drugs/clinical trials and news about KDM2B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KDM2B gene (2 alternative transcripts):

NM_001005366.1 NM_032590.4

Unigene Cluster for KDM2B:

Lysine (K)-specific demethylase 2B

Hs.524800 [show with all ESTs]

Unigene Representative Sequence: NM_032590

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000542973(uc001uap.3 uc001uaq.3) ENST00000538503(uc001uao.3 uc010szx.2 uc010szy.2 uc001uar.3)

ENST00000377069(uc001uas.3 uc021rfd.1) ENST00000377071(uc001uat.3 uc001uau.3 uc021rfe.1)

ENST00000543025 ENST00000536036 ENST00000545994 ENST00000538243 ENST00000538046(uc001uav.4)

ENST00000446152 ENST00000542030 ENST00000538379 ENST00000545022 ENST00000541318

ENST00000543852 ENST00000541511 ENST00000539394 ENST00000539371

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		hsa-miR-411* hsa-miR-148b* hsa-miR-379* hsa-miR-146a hsa-miR-586 hsa-miR-3065-5p hsa-miR-183 hsa-miR-200a

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Additional cDNA sequence:

AB031230.1 AJ459424.1 AK027440.1 AK027692.1 AK055282.1 AK074718.1 AK127328.1 AK299827.1

AK316470.1 BC008735.2 BC028612.1 BC115379.1 BC115380.1 BX648928.1

24 DOTS entries:

DT.100779771 DT.95167649 DT.100779773 DT.100731611 DT.100779774 DT.75150484 DT.99954855 DT.100779777

DT.101983427 DT.95241592 DT.402976 DT.100655267 DT.100689945 DT.121128640 DT.121128658 DT.121128677

DT.95208361 DT.97836402 DT.100697037 DT.121128657 DT.121128720 DT.95262506 DT.86840697 DT.95249316

24/205 AceView cDNA sequences (see all 205):

AI343298 AA648887 BM783125 BG538934 BM757786 AB031230 BX108493 AI088992

AI472214 AI870035 AI288446 BG283856 BI819191 AA336363 AK127328 BQ898120

BE328676 AA361882 AW196603 BM740439 AA907525 BM759660 AA070843 AW514897

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for KDM2B (see all 15) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	·	13c	^	14	^	15	^	16	^	17a	·
SP1:
SP2:
SP3:
SP4:
SP5:							-						-				-										-		-

ExUns:	17b	^	18	^	19	^	20	^	21a	·	21b	^	22	^	23a	·	23b	·	23c	^	24	^	25	^	26	^	27a	·	27b	^	28	^	29	^	30	^	31a	·	31b	^	32a	·	32b	·	32c	·	32d
SP1:					-																																		-
SP2:					-										-																				-
SP3:															-																				-
SP4:																																			-
SP5:

ECgene alternative splicing isoforms for KDM2B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KDM2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTATTTCCT

About this image

KDM2B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Pancreas

Islets of Langerhans

Mature Beta Cells

Pancreas

Kidney

Metanephros

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KDM2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KDM2B

SOURCE GeneReport for Unigene cluster: Hs.524800

SABiosciences Expression via Pathway-Focused PCR Arrays including KDM2B:

Polycomb & Trithorax Complexes in human mouse rat

Ubiquitin Ligases in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KDM2B gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Kdm2b^{1 , 5}	lysine (K)-specific demethylase 2B^{1, 5}	89.39(n)¹ 94.9(a)¹		5 (62.63 cM)⁵ 30841¹ NM_001003953.1¹ NP_001003953.1¹ 122870668⁵
chicken (Gallus gallus)	Aves	KDM2B¹	lysine (K)-specific demethylase 2B	78.77(n) 87.9(a)		416844 XM_415137.3 XP_415137.3
lizard (Anolis carolinensis)	Reptilia	KDM2B⁶	--	78(a)	1 ↔ 1	GL343550.1(44269-117133)
African clawed frog (Xenopus laevis)	Amphibia	Xl.7069²	Xenopus laevis transcribed sequence with moderate similarity more	76.61(n)		BX852634.1
zebrafish (Danio rerio)	Actinopterygii	kdm2a¹	lysine (K)-specific demethylase 2A	54.49(n) 50.72(a)		799441 XM_001339761.3 XP_001339797.2
fruit fly (Drosophila melanogaster)	Insecta	Kdm2⁶	Lysine (K)-specific demethylase 2	30(a)	1 → many	3R(4878240-4888967)

ENSEMBL Gene Tree for KDM2B (if available)
TreeFam Gene Tree for KDM2B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for KDM2B gene

PHF2² PHF8² KDM2A² JHDM1D² FBXL19²

5 SIMAP similar genes for KDM2B using alignment to 11 protein entries: KDM2B_HUMAN (see all proteins):

FBXL10 KDM2A PHF8 FBXL19 kdm2a

KDM2B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79563986^1,2	C,F,	--	121866736(+)	`GAGCAG/ACTCTT`	2	--	ds500¹		5		NA CSA WA	244
rs147172309^1,2	C,	--	121866761(+)	`GTGTC-/TTAATT`	2	--	ds500¹		0	--	--	--	--
rs142411572^1,2		--	121866768(+)	`TAATTC/TCTACG`	2	--	ds500¹		0	--	--	--	--
rs183980625^1,2		--	121866774(+)	`CTACGC/TGTGGC`	2	--	ds500¹		0	--	--	--	--
rs151292455^1,2		--	121866846(+)	`CTGAAA/GAAAGA`	2	--	ds500¹		0	--	--	--	--
rs140610678^1,2		--	121866861(+)	`TGACGC/TACCAC`	2	--	ds500¹		0	--	--	--	--
rs117682549^1,2		--	121866905(+)	`TTGGAC/TTTCAA`	2	--	ut3¹		1		NA	120
rs144247530^1,2		--	121866948(+)	`TAGTCC/TACTCC`	2	--	ut3¹		0	--	--	--	--
rs146560042^1,2		--	121866985(+)	`AGTGGG/TTTTTT`	2	--	ut3¹		0	--	--	--	--
rs11065570^1,2	C,F,H	--	121867221(+)	`AATTAG/AATCTA`	2	--	ut3¹		10		NS EA NA	1134

HapMap Linkage Disequilibrium report for KDM2B (121866899 - 122018920 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for KDM2B
3 Indels: 76167 86592 76166

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KDM2B

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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KDM2B for disorders           About GeneDecksing

OMIM gene information: 609078    OMIM disorders: --

2 diseases for KDM2B:    About MalaCards

coloboma neuronitis

Human Genome Epidemiology (HuGE) Navigator: KDM2B (1 document)

Export disorders for KDM2B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KDM2B gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with KDM2B)

Utopia: connect your pdf to the dynamic
world of online information

JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes. (PubMed id 17994099)^{1, 2, 9} Frescas D....Pagano M. (2007)
Histone demethylation by a family of JmjC domain-containing proteins. (PubMed id 16362057)^{1, 2} Tsukada Y.... Zhang Y. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis. (PubMed id 10799292)^{1, 3} Fujino T.... Takano T. (2000)
The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun. (PubMed id 17704768)^{1, 9} Koyama-Nasu R....Tanese N. (2007)
Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. (PubMed id 16943429)^{1, 9} Gearhart M.D.... Bardwell V.J. (2006)
JmjC-domain containing histone demethylase 1B-mediated p15(Ink4b) suppression promotes the proliferation of leukemic progenitor cells through modulation of cell cycle progression in acute myeloid leukemia. (PubMed id 22086844)¹ Nakamura S....Ohnishi K. (2013)
The H3K4me3 histone demethylase Fbxl10 is a regulator of chemokine expression, cellular morphology, and the metabolome of fibroblasts. (PubMed id 22825849)¹ Janzer A....Kirfel J. (2012)
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resi stance. (PubMed id 22581228)¹ Manning A.K....Langenberg C. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84678	HGNC: 13610	AceView: FBXL10	Ensembl:ENSG00000089094	euGenes: HUgn84678
ECgene: KDM2B	H-InvDB: KDM2B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for KDM2B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KDM2B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KDM2B gene:
Search GeneIP for patents involving KDM2B

GeneCards and IP:
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KDM2B Gene

lysine (K)-specific demethylase 2B

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KDM2B (Gene Symbol)
Lysine (K)-Specific Demethylase 2B
CXXC2
FBXL10
JHDM1B
PCCX2
F-Box And Leucine-Rich Repeat Protein 10
Fbl10
JmjC Domain-Containing Histone Demethylation Protein 1B
Jumonji Domain-Containing EMSY-Interactor Methyltransferase Motif Protein
Protein-Containing CXXC Domain 2
[Histone-H3]-Lysine-36 Demethylase 1B
CXXC-Type Zinc Finger Protein 2
F-Box Protein FBL10
F-Box/LRR-Repeat Protein 10
EC 1.14.11.27
JEMMA (Jumonji Domain, EMSY-Interactor, Methyltransferase Motif) Protein
Jumonji C Domain-Containing Histone Demethylase 1B
Lysine-Specific Demethylase 2B
FBL10
Protein JEMMA

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KDM2B Gene

lysine (K)-specific demethylase 2B

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