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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KDM2A Gene

protein-coding   GIFtS: 56
GCID: GC11P066888

lysine (K)-specific demethylase 2A

(Previous name: F-box and leucine-rich repeat protein 11 )
(Previous symbol: FBXL11)
 Explore 2 diseases affiliated with
KDM2A via
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Biological research products
for KDM2A    

Aliases
for KDM2A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Lysine (K)-Specific Demethylase 2A1 2     [Histone-H3]-Lysine-36 Demethylase 1A2 3
FBXL111 2 3 5     CXXC-Type Zinc Finger Protein 82 3
CXXC81 2 3     F-Box/LRR-Repeat Protein 112 3
FBL71 2 3     EC 1.14.11.273 8
JHDM1A1 2 3     DKFZP434M17351
F-Box And Leucine-Rich Repeat Protein 111 2 3     FLJ001151
FBL111 2 5     Jumonji C Domain-Containing Histone Demethylase 1A2
LILINA1 2     Lysine-Specific Demethylase 2A2
KIAA10041 3     F-Box Protein FBL73
JmjC Domain-Containing Histone Demethylation Protein 1A2 3     F-Box Protein Lilina3

External Ids:    HGNC: 136061   Entrez Gene: 229922   Ensembl: ENSG000001731207   OMIM: 6056575   UniProtKB: Q9Y2K73   
ORGUL members:         
NONCODE:n407908    

Export aliases for KDM2A gene to outside databases

Previous GC identifers: GC11P066646 GC11P063214


Summaries
for KDM2A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KDM2A:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,
the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs
(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3
classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different
protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls
class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member
plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and
di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. (provided by
RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: KDM2A_HUMAN, Q9Y2K7
Function: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in
histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono-
and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their
ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and
represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the
centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis

Gene Wiki entry for KDM2A


Genomic Views
for KDM2A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KDM2A gene promoter:
         AhR   AP-2gamma   C/EBPalpha   CREB   MZF-1   deltaCREB   FOXO4   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KDM2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDM2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.1

KDM2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDM2A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P066888:  view genomic region     (about GC identifiers)

Start:
 66,886,740 bp from pter      End:
 67,025,553 bp from pter
Size:
 138,814 bases      Orientation:
 plus strand

Proteins
for KDM2A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KDM2A_HUMAN, Q9Y2K7 (See protein sequence)
Recommended Name: Lysine-specific demethylase 2A  
Size: 1162 amino acids; 132793 Da
Cofactor: Binds 1 Fe(2+) ion per subunit
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). Interacts with CBX5/HP1A; the
interaction promotes CBX5 localization to chromatin
Subcellular location: Nucleus, nucleoplasm. Note=Punctate expression throughout the nucleoplasm and enriched in the
perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in
H3K36me2
Sequence caution: Sequence=AAD56012.1; Type=Erroneous initiation; Sequence=BAA76848.2; Type=Erroneous initiation;
Sequence=BAB15795.1; Type=Frameshift; Positions=410;
3 PDB 3D structures from and Proteopedia for KDM2A:
2YU1 (3D)        2YU2 (3D)        4BBQ (3D)    
Secondary accessions: Q49A21 Q4G0M3 Q69YY8 Q9BVH5 Q9H7H5 Q9UK66
Alternative splicing: 3 isoforms:  Q9Y2K7-1   Q9Y2K7-2   Q9Y2K7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KDM2A: NX_Q9Y2K7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y2K7

    • 4/10 DME Specific Peptides for KDM2A (Q9Y2K7) (see all 10)
     IHAVYTP  GLGIKMP  GTSVWYH  DNRSKLRN 

    KDM2A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243334.1  NP_036440.1  

    ENSEMBL proteins: 
     ENSP00000381640   ENSP00000432786   ENSP00000435776   ENSP00000309302  

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    Novus Biologicals KDM2A Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KDM2A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IEA--
    GO:0005654nucleoplasm IEA--


    KDM2A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KDM2A

    Protein Domains /
    Families
    for KDM2A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KDM2A for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR002857 Znf_CXXC
     IPR001810 F-box_dom_cyclin-like
     IPR003347 JmjC_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y2K7

    ProtoNet protein and cluster: Q9Y2K7

    1 Blocks protein family: IPB001965 Zn-finger-like

    UniProtKB/Swiss-Prot: KDM2A_HUMAN, Q9Y2K7
    Domain: The JmjC domain mediates demethylation activity and is required for satellite silencing
    Domain: The CXXC zinc finger preferentially recognizes nonmethylated CpG DNA, and binding is blocked when the CpG DNA
    is methylated
    Similarity: Belongs to the JHDM1 histone demethylase family
    Similarity: Contains 1 CXXC-type zinc finger
    Similarity: Contains 1 F-box domain
    Similarity: Contains 1 JmjC domain
    Similarity: Contains 6 LRR (leucine-rich) repeats
    Similarity: Contains 1 PHD-type zinc finger


    Function
    for KDM2A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KDM2A_HUMAN, Q9Y2K7
    Function: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in
    histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono-
    and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their
    ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and
    represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the
    centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis
    Catalytic activity: Protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) = protein N(6)-methyl-L-lysine +
    succinate + formaldehyde + CO(2)
    Catalytic activity: Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) = protein L-lysine + succinate + formaldehyde
    + CO(2)

    Enzyme Number (IUBMB): EC 1.14.11.271 2

    miRNA
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    hsa-miR-3130-5p hsa-miR-520e hsa-miR-106a hsa-miR-759 hsa-miR-519a hsa-miR-3916 hsa-miR-4267 hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmid: KDM2A 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA--
    GO:0045322unmethylated CpG binding IEA--
    GO:0051864histone demethylase activity (H3-K36 specific) IEA--


    KDM2A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for KDM2A:
     Synthetic lethal with Ras 


    Pathways & Interactions
    for KDM2A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KDM2A

    5/18 Interacting proteins for KDM2A (Q9Y2K72, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840222, 3MINT-61697 I2D: score=3 
    SMAD7O151052, 3MINT-61809 I2D: score=3 
    ZNF512BQ96KM62, 3MINT-60816 I2D: score=2 
    HIST2H3AQ71DI33I2D: score=1 
    HIST2H3CQ71DI33I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0070544histone H3-K36 demethylation IMP--


    KDM2A for ontologies           About GeneDecksing



    Drugs & Compounds
    for KDM2A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for KDM2A

    2 HMDB Compounds for KDM2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    FormaldehydeAldeide formica (see all 16)50-00-0--
    L-Lysine(+)-S-Lysine (see all 25)56-87-1--
    Search CenterWatch for drugs/clinical trials and news about KDM2A 

    Transcripts
    for KDM2A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KDM2A gene (2 alternative transcripts): 
    NM_001256405.1  NM_012308.2  

    Unigene Cluster for KDM2A:

    Lysine (K)-specific demethylase 2A
    Hs.124147  [show with all ESTs]
    Unigene Representative Sequence: NM_012308
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398645(uc001ojx.3 uc001ojw.3) ENST00000529006 ENST00000532436
    ENST00000527157 ENST00000528380 ENST00000526258(uc001ojy.3 uc010rpn.2)
    ENST00000531696 ENST00000525379 ENST00000525041 ENST00000530342 ENST00000517637
    ENST00000529124 ENST00000534486 ENST00000524657(uc001oka.3) ENST00000308783(uc001ojz.1)


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    hsa-miR-3130-5p hsa-miR-520e hsa-miR-106a hsa-miR-759 hsa-miR-519a hsa-miR-3916 hsa-miR-4267 hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmid: KDM2A 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB023221.2 AB490246.1 AF179221.1 AK022684.1 AK024505.1 AK096194.1 AK128293.1 AK299725.1 
    AL117517.1 BC001203.1 BC027467.1 BC047371.1 BC047486.1 BC056905.1 BC064360.1 NR_027473.1 

    24 DOTS entries:

    DT.97801199  DT.316275  DT.316277  DT.86845905  DT.70104715  DT.97759949  DT.120729368  DT.95099498 
    DT.95113871  DT.95332315  DT.92039627  DT.91752678  DT.92361530  DT.120729422  DT.75110445  DT.91964363 
    DT.92060027  DT.100729580  DT.75175471  DT.91697320  DT.91803466  DT.91856680  DT.95258767  DT.98083654 

    24/423 AceView cDNA sequences (see all 423):

    AA236205 AW664429 AW501052 AA255440 BC064360 AI093127 AI672734 BG391443 
    AI247634 BM717847 AI497901 BM720840 CA427689 BC047486 BQ008080 AA400365 
    BQ691937 AI185920 BM799099 BF813651 BU166844 BM991580 Z40711 AW590126 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for KDM2A (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a ·
    SP1:                          -           -           -                 -           -                 -                       -           -                 -   
    SP2:                                                                                                                                      -                 -   
    SP3:                                                                                                                          -     -     -                 -   
    SP4:                                                                                                                                                        -   
    SP5:                                                                                                                                                        -   

    ExUns: 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25
    SP1:              -           -     -     -                           
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  
    SP5:              -                                                   


    ECgene alternative splicing isoforms for KDM2A

    Expression
    for KDM2A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KDM2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCTACAATC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See KDM2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KDM2A

    SOURCE GeneReport for Unigene cluster: Hs.124147

    UniProtKB/Swiss-Prot: KDM2A_HUMAN, Q9Y2K7
    Tissue specificity: Widely expressed, with highest levels in brain, testis and ovary, followed by lung

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    Orthologs
    for KDM2A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KDM2A gene from 5/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KDM2A1 lysine (K)-specific demethylase 2A 79.37(n)
    87.33(a)    		   425999  XM_423678.3  XP_423678.3 
    lizard
    (Anolis carolinensis)    		 Reptilia KDM2A6
    		 --
    		 71(a)
    		 1 ↔ 1
    		 1(92659028-92699444)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BJ618511.12   -- 76.21(n)    BJ618511.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii 570668532   -- 78.26(n)    57066853 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Kdm21 Lysine (K)-specific demethylase 2 48.82(n)
    44.12(a)    		   41090  NM_141607.2  NP_649864.2 


    ENSEMBL Gene Tree for KDM2A (if available)
    TreeFam Gene Tree for KDM2A (if available) 

    Paralogs
    for KDM2A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KDM2A gene
    PHF22  PHF82  JHDM1D2  KDM2B2  FBXL192  
    5 SIMAP similar genes for KDM2A using alignment to 6 protein entries:     KDM2A_HUMAN (see all proteins):
    kdm2a    KDM2B    FBXL10    PHF8    FBXL19

    KDM2A for paralogs           About GeneDecksing



    Genomic Variants
    for KDM2A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1938 NCBI SNPs in KDM2A are shown (see all 1938)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs744857781,2
    		C,F,--66884782(+) TTCAGT/CTGTCT 2 -- us2k11Minor allele frequency- C:0.06NA 120
    rs750810471,2
    		C,--66885054(+) TGATTC/GACTCC 2 -- us2k15Minor allele frequency- G:0.08CSA WA NA EA 361
    rs1913312861,2
    		--66885129(+) GGCAGG/TGAGAA 2 -- us2k10--------
    rs1172660311,2
    		C,--66885182(+) AATAGT/GGCCAA 2 -- us2k11Minor allele frequency- G:0.01EA 120
    rs1175382551,2
    		F,--66885213(+) GCCACC/TGTCCT 2 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1507228761,2
    		--66885730(+) GTCGCA/GGAGAC 2 -- us2k10--------
    rs1390775111,2
    		--66886067(+) CCCGCA/GGGCCC 2 -- us2k10--------
    rs122845461,2
    		C,F,H,--66886145(+) CCGGCC/TCTCAG 2 -- us2k17Minor allele frequency- T:0.17NS WA 1222
    rs1409603821,2
    		--66887488(+) CTTCTC/TACTTG 2 -- nc-transcript-variantut510--------
    rs1449206851,2
    		--66887531(+) TTTCCC/TCCTCC 2 -- int10--------

    HapMap Linkage Disequilibrium report for KDM2A (66886740 - 67025553 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for KDM2A
         3 CNVs: 23418 22971 65978

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    Disorders / Diseases
    for KDM2A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KDM2A for disorders           About GeneDecksing

    OMIM gene information: 605657    OMIM disorders: --

    2 diseases for KDM2A:    About MalaCards
    fanconi's anemia    anemia


    Export disorders for KDM2A gene to outside databases

    Publications
    for KDM2A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KDM2A gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with KDM2A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. CpG islands recruit a histone H3 lysine 36 demethylase. (PubMed id 20417597)1, 2 Blackledge N.P....Klose R.J. (2010)
    3. KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state. (PubMed id 19001877)1, 2 Frescas D....Pagano M. (2008)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Histone demethylation by a family of JmjC domain-containing proteins. (PubMed id 16362057)1, 2 Tsukada Y.... Zhang Y. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    8. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. (PubMed id 10945468)1, 2 Ilyin G.P.... Guguen-Guillouzo C. (2000)
    9. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 2 Hattori A.... Ohara O. (2000)
    10. A family of mammalian F-box proteins. (PubMed id 10531037)1, 3 Winston J.T....Harper J.W. (1999)

    External Searches for KDM2A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing KDM2A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22992 HGNC: 13606 AceView: FBXL11 Ensembl:ENSG00000173120 euGenes: HUgn22992
    ECgene: KDM2A H-InvDB: KDM2A

    Other Databases showing KDM2A gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1004

    Specialized Databases showing KDM2A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KDM2A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KDM2A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KDM2A gene:
    Search GeneIP for patents involving KDM2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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