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Aliases for KDM2A Gene

Aliases for KDM2A Gene

  • Lysine Demethylase 2A 2 3 5
  • F-Box And Leucine-Rich Repeat Protein 11 2 3 4
  • JmjC Domain-Containing Histone Demethylation Protein 1A 3 4
  • Jumonji C Domain-Containing Histone Demethylase 1A 2 3
  • [Histone-H3]-Lysine-36 Demethylase 1A 3 4
  • Lysine (K)-Specific Demethylase 2A 2 3
  • CXXC-Type Zinc Finger Protein 8 3 4
  • F-Box/LRR-Repeat Protein 11 3 4
  • EC 1.14.11.27 4 61
  • FBXL11 3 4
  • JHDM1A 3 4
  • CXXC8 3 4
  • FBL7 3 4
  • Lysine-Specific Demethylase 2A 3
  • F-Box Protein Lilina 4
  • F-Box Protein FBL11 2
  • F-Box Protein FBL7 4
  • KIAA1004 4
  • LILINA 3
  • FBL11 3

External Ids for KDM2A Gene

Previous HGNC Symbols for KDM2A Gene

  • FBXL11

Previous GeneCards Identifiers for KDM2A Gene

  • GC11P066646
  • GC11P066888
  • GC11P063214

Summaries for KDM2A Gene

Entrez Gene Summary for KDM2A Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for KDM2A Gene

KDM2A (Lysine Demethylase 2A) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin organization. GO annotations related to this gene include histone demethylase activity (H3-K36 specific) and unmethylated CpG binding. An important paralog of this gene is KDM2B.

UniProtKB/Swiss-Prot for KDM2A Gene

  • Histone demethylase that specifically demethylates Lys-36 of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 Lys-36 residue while it has weak or no activity for mono- and tri-methylated H3 Lys-36. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.

Gene Wiki entry for KDM2A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KDM2A Gene

Genomics for KDM2A Gene

Regulatory Elements for KDM2A Gene

Enhancers for KDM2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G067077 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.7 -40.9 -40927 2.5 TBP SREBF2 AGO1 KLF17 BRCA1 EGR1 ZNF366 FOS DEK EGR2 RHOD KDM2A ANKRD13D CDK2AP2 GRK2 RBM4 CLCF1 SSH3 TMEM134 PITPNM1
GH11G067265 1.8 FANTOM5 ENCODE dbSUPER 13.2 +159.2 159197 25.5 CREB3L1 MLX AGO1 ZFP64 DMAP1 YBX1 FEZF1 YY1 SLC30A9 ZNF143 SSH3 ENSG00000258297 GRK2 KDM2A ANKRD13D RBM14 PTPRCAP MRPL11 RHOD CARNS1
GH11G067081 1.4 Ensembl ENCODE dbSUPER 11.5 -37.3 -37276 1.2 NFIB ARID4B BRCA1 RAD21 RFX5 ZNF143 PCBP1 DEK THAP11 SMARCA5 KDM2A SYT12 RNU7-23P GC11P067094 RHOD
GH11G067167 1.2 Ensembl ENCODE 11.9 +48.8 48833 1.8 ATF1 PKNOX1 ARNT CREB3L1 SIN3A TCF12 ELK1 GATA2 FOS DEK SSH3 KDM2A RHOD ENSG00000179038
GH11G067144 1 Ensembl ENCODE 11.8 +26.6 26633 1.9 FOXA2 PKNOX1 SAP130 ZNF792 JUN DMAP1 ZNF384 ZNF644 ZNF366 FOS KDM2A PTPRCAP RHOD SSH3 CARNS1 ENSG00000179038
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KDM2A on UCSC Golden Path with GeneCards custom track

Promoters for KDM2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000041066 732 4401 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 REST

Genomic Location for KDM2A Gene

Chromosome:
11
Start:
67,119,268 bp from pter
End:
67,258,087 bp from pter
Size:
138,820 bases
Orientation:
Plus strand

Genomic View for KDM2A Gene

Genes around KDM2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KDM2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KDM2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KDM2A Gene

Proteins for KDM2A Gene

  • Protein details for KDM2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2K7-KDM2A_HUMAN
    Recommended name:
    Lysine-specific demethylase 2A
    Protein Accession:
    Q9Y2K7
    Secondary Accessions:
    • D4QA03
    • E9PIL6
    • I3VM55
    • Q49A21
    • Q4G0M3
    • Q69YY8
    • Q9BVH5
    • Q9H7H5
    • Q9UK66

    Protein attributes for KDM2A Gene

    Size:
    1162 amino acids
    Molecular mass:
    132793 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). Interacts with CBX5/HP1A; the interaction promotes CBX5 localization to chromatin.
    SequenceCaution:
    • Sequence=AAD56012.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA76848.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15795.1; Type=Frameshift; Positions=410; Evidence={ECO:0000305}; Sequence=BAJ05817.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KDM2A Gene

    Alternative splice isoforms for KDM2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KDM2A Gene

Selected DME Specific Peptides for KDM2A Gene

Q9Y2K7:
  • IPSGWIHAV
  • GTSVWYH
  • GLGIKMP
  • CQRIELKQG
  • KFRYPFYYEMCWYVLERYV
  • ELPNCWECPKC
  • WCCDKRLWT
  • DNRSKLRN
  • IHAVYTP
  • DVMDVNTQK

Post-translational modifications for KDM2A Gene

  • Ubiquitination at posLast=518518
  • Modification sites at PhosphoSitePlus

Domains & Families for KDM2A Gene

Suggested Antigen Peptide Sequences for KDM2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2K7

UniProtKB/Swiss-Prot:

KDM2A_HUMAN :
  • The JmjC domain mediates demethylation activity and is required for satellite silencing.
  • Belongs to the JHDM1 histone demethylase family.
Domain:
  • The JmjC domain mediates demethylation activity and is required for satellite silencing.
  • The CXXC zinc finger preferentially recognizes nonmethylated CpG DNA, and binding is blocked when the CpG DNA is methylated.
Family:
  • Belongs to the JHDM1 histone demethylase family.
genes like me logo Genes that share domains with KDM2A: view

Function for KDM2A Gene

Molecular function for KDM2A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO(2).
UniProtKB/Swiss-Prot CatalyticActivity:
Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) = protein L-lysine + succinate + formaldehyde + CO(2).
UniProtKB/Swiss-Prot Function:
Histone demethylase that specifically demethylates Lys-36 of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 Lys-36 residue while it has weak or no activity for mono- and tri-methylated H3 Lys-36. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.

Enzyme Numbers (IUBMB) for KDM2A Gene

Gene Ontology (GO) - Molecular Function for KDM2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 15070733
GO:0008168 methyltransferase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with KDM2A: view
genes like me logo Genes that share phenotypes with KDM2A: view

Animal Models for KDM2A Gene

MGI Knock Outs for KDM2A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KDM2A Gene

Localization for KDM2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDM2A Gene

Nucleus, nucleoplasm. Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where its presence results in chromatin depleted in H3K36me2.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KDM2A gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for KDM2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with KDM2A: view

Pathways & Interactions for KDM2A Gene

genes like me logo Genes that share pathways with KDM2A: view

Pathways by source for KDM2A Gene

1 GeneTex pathway for KDM2A Gene

SIGNOR curated interactions for KDM2A Gene

Inactivates:

Gene Ontology (GO) - Biological Process for KDM2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006303 double-strand break repair via nonhomologous end joining IMP 21187428
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016569 covalent chromatin modification IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with KDM2A: view

Drugs & Compounds for KDM2A Gene

(11) Drugs for KDM2A Gene - From: ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbon dioxide Approved, Vet_approved Pharma 0
Formaldehyde Approved, Vet_approved Pharma 93
Oxygen Approved, Vet_approved Pharma 0
L-Lysine Approved Nutra Full agonist, Agonist 0
Succinic acid Approved Nutra Full agonist, Agonist 0

(1) Additional Compounds for KDM2A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Oxoglutaric acid
  • 2-Ketoglutarate
  • 2-Ketoglutaric acid
  • 2-Oxo-1,5-pentanedioate
  • 2-Oxo-1,5-pentanedioic acid
  • 2-Oxoglutarate
328-50-7

(6) ApexBio Compounds for KDM2A Gene

Compound Action Cas Number
Daminozide KDM2A inhibitor 1596-84-5
IOX 1 5852-78-8
ML324 JMJD2 demethylase inhibitor, potent and cell-permeable 1222800-79-4
SP2509 Demethylase 1 (LSD1) antagonist, novel Lysine-specific 1423715-09-6
TC-E 5002 1453071-47-0
Tranylcypromine hydrochloride 1986-47-6
genes like me logo Genes that share compounds with KDM2A: view

Drug Products

Transcripts for KDM2A Gene

Unigene Clusters for KDM2A Gene

Lysine (K)-specific demethylase 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KDM2A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a ·
SP1: - - - - - - - - -
SP2: - -
SP3: - - - -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:

ExUns: 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25
SP1: - - - -
SP2:
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for KDM2A Gene

GeneLoc Exon Structure for
KDM2A
ECgene alternative splicing isoforms for
KDM2A

Expression for KDM2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KDM2A Gene

Protein differential expression in normal tissues from HIPED for KDM2A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.0), Plasma (9.2), CD8 Tcells (7.1), and Bone marrow stromal cell (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KDM2A Gene



Protein tissue co-expression partners for KDM2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KDM2A Gene:

KDM2A

SOURCE GeneReport for Unigene cluster for KDM2A Gene:

Hs.124147

mRNA Expression by UniProt/SwissProt for KDM2A Gene:

Q9Y2K7-KDM2A_HUMAN
Tissue specificity: Widely expressed, with highest levels in brain, testis and ovary, followed by lung.

Evidence on tissue expression from TISSUES for KDM2A Gene

  • Nervous system(4.6)
  • Eye(4.4)
  • Spleen(4.3)
  • Blood(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with KDM2A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KDM2A Gene

Orthologs for KDM2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KDM2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KDM2A 34 35
  • 99.89 (n)
oppossum
(Monodelphis domestica)
Mammalia KDM2A 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KDM2A 34 35
  • 95.81 (n)
cow
(Bos Taurus)
Mammalia KDM2A 34 35
  • 94.83 (n)
rat
(Rattus norvegicus)
Mammalia Kdm2a 34
  • 92.28 (n)
mouse
(Mus musculus)
Mammalia Kdm2a 34 16 35
  • 92.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KDM2A 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves KDM2A 34 35
  • 79.37 (n)
lizard
(Anolis carolinensis)
Reptilia KDM2A 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kdm2a 34
  • 65.66 (n)
Str.10470 34
zebrafish
(Danio rerio)
Actinopterygii kdm2a 34
  • 63.93 (n)
CT955967.1 35
  • 50 (a)
OneToMany
kdm2aa 35
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Kdm2 34 35
  • 52.46 (n)
worm
(Caenorhabditis elegans)
Secernentea jhdm-1 35
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes JHD1 35 37
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8451 34
Species where no ortholog for KDM2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KDM2A Gene

ENSEMBL:
Gene Tree for KDM2A (if available)
TreeFam:
Gene Tree for KDM2A (if available)

Paralogs for KDM2A Gene

Paralogs for KDM2A Gene

(4) SIMAP similar genes for KDM2A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KDM2A: view

Variants for KDM2A Gene

Sequence variations from dbSNP and Humsavar for KDM2A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000012707 -- 67,164,844(+) TCTAC(A/C)CACCT intron-variant
rs1000035252 -- 67,230,659(+) AAAAA(A/C)CCACA intron-variant
rs1000071816 -- 67,126,451(+) GCCTG(C/T)GATCC intron-variant
rs1000080769 -- 67,183,127(+) AAACC(C/G)TGGCC intron-variant
rs1000095289 -- 67,160,099(+) TTCCC(C/T)GATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KDM2A Gene

Variant ID Type Subtype PubMed ID
dgv1976n54 CNV loss 21841781
esv1081118 CNV insertion 17803354
esv23935 CNV loss 19812545
esv2661599 CNV deletion 23128226
esv2669621 CNV deletion 23128226
esv2744644 CNV deletion 23290073
esv3328967 CNV duplication 20981092
esv3626707 CNV loss 21293372
esv3626709 CNV loss 21293372
nsv1069600 CNV deletion 25765185
nsv1121839 CNV deletion 24896259
nsv436787 CNV insertion 17901297
nsv472571 CNV novel sequence insertion 20440878
nsv509419 CNV insertion 20534489
nsv513322 CNV insertion 21212237
nsv555252 CNV loss 21841781
nsv825958 CNV gain 20364138
nsv825959 CNV gain 20364138
nsv972951 CNV duplication 23825009

Variation tolerance for KDM2A Gene

Residual Variation Intolerance Score: 1.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KDM2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KDM2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KDM2A Gene

Disorders for KDM2A Gene

Relevant External Links for KDM2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KDM2A

No disorders were found for KDM2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KDM2A Gene

Publications for KDM2A Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. CpG islands recruit a histone H3 lysine 36 demethylase. (PMID: 20417597) Blackledge N.P. … Klose R.J. (Mol. Cell 2010) 3 4 64
  3. Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB. (PMID: 19805303) Lu T. … Stark G.R. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 22 64
  4. KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state. (PMID: 19001877) Frescas D. … Pagano M. (Cell Cycle 2008) 3 4 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for KDM2A Gene

Sources for KDM2A Gene

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