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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KDM1B Gene

protein-coding   GIFtS: 47
GCID: GC06P018156

Lysine (K)-Specific Demethylase 1B

(Previous names: amine oxidase, flavin containing 1, chromosome 6 open reading...)
(Previous symbols: C6orf193, AOF1)
  Search for KDM1B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lysine (K)-Specific Demethylase 1B1 2     Lysine-Specific Histone Demethylase 22 3
AOF11 2 3 5     Chromosome 6 Open Reading Frame 1931
C6orf1931 2 3     bA204B7.32
LSD22 3 5     dJ298J15.22
Amine Oxidase (Flavin Containing) Domain 11 2     Lysine-Specific Histone Demethylase 1B2
Amine Oxidase, Flavin Containing 11 2     EC 1.-.-.-3
Flavin-Containing Amine Oxidase Domain-Containing Protein 12 3     

External Ids:    HGNC: 215771   Entrez Gene: 2216562   Ensembl: ENSG000001650977   OMIM: 6130815   UniProtKB: Q8NB783   

Export aliases for KDM1B gene to outside databases

Previous GC identifer: GC06P018266


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KDM1B Gene:
Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that
regulates gene expression and chromatin function (Karytinos et al., 2009 (PubMed 19407342)).(supplied by OMIM,
Oct 2009)

GeneCards Summary for KDM1B Gene: 
KDM1B (lysine (K)-specific demethylase 1B) is a protein-coding gene. GO annotations related to this gene include oxidoreductase activity and histone demethylase activity (H3-dimethyl-K4 specific). An important paralog of this gene is SMOX.

UniProtKB/Swiss-Prot: KDM1B_HUMAN, Q8NB78
Function: Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic
transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of
imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that
is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on
tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di-
or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for KDM1B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKDM1B promoter sequence
   Search SABiosciences Chromatin IP Primers for KDM1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDM1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22.3

KDM1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDM1B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P018156:  view genomic region     (about GC identifiers)

Start:
18,155,560 bp from pter      End:
18,224,084 bp from pter
Size:
68,525 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KDM1B_HUMAN, Q8NB78 (See protein sequence)
Recommended Name: Lysine-specific histone demethylase 1B  
Size: 822 amino acids; 92098 Da
Cofactor: FAD (By similarity)
Subunit: Does not form a complex with RCOR1/CoREST (By similarity)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAC03663.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
6/10 PDB 3D structures from and Proteopedia for KDM1B (see all 10):
4FWE (3D)        4FWF (3D)        4FWJ (3D)        4GU0 (3D)        4GU1 (3D)        4GUR (3D)    
Secondary accessions: A2A2C5 A2A2C6 Q5TGV3 Q6AI15 Q6ZUU4 Q8N258 Q96EL7
Alternative splicing: 3 isoforms:  Q8NB78-1   Q8NB78-2   Q8NB78-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KDM1B: NX_Q8NB78

Explore proteomics data for KDM1B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NB78

  • KDM1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KDM1B Protein Expression
    REFSEQ proteins: NP_694587.3  
    ENSEMBL proteins: 
     ENSP00000442670   ENSP00000297792   ENSP00000405669   ENSP00000373522   ENSP00000380419  

    Human Recombinant Protein Products for KDM1B: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for KDM1B 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS19727073

    KDM1B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KDM: Chromatin-modifying enzymes / K-demethylases

    5 InterPro protein domains:
     IPR002937 Amino_oxidase
     IPR011991 WHTH_DNA-bd_dom
     IPR009057 Homeodomain-like
     IPR007526 SWIRM
     IPR011124 Znf_CW

    Graphical View of Domain Structure for InterPro Entry Q8NB78

    ProtoNet protein and cluster: Q8NB78

    1 Blocks protein domain: IPB007526 SWIRM

    UniProtKB/Swiss-Prot: KDM1B_HUMAN, Q8NB78
    Domain: The SWIRM domain may act as an anchor site for a histone tail (By similarity)
    Similarity: Belongs to the flavin monoamine oxidase family
    Similarity: Contains 1 CW-type zinc finger
    Similarity: Contains 1 SWIRM domain


    KDM1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KDM1B_HUMAN, Q8NB78
    Function: Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic
    transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of
    imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that
    is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on
    tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di-
    or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (By
    similarity)

         Enzyme Number (IUBMB): EC 1.-.-.-1

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016491oxidoreductase activity IEA--
    GO:0034648histone demethylase activity (H3-dimethyl-K4 specific) ISS19727073
         
    KDM1B for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kdm1b):
     no phenotypic analysis  other  reproductive system 

    KDM1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Kdm1btm1.1Tche for KDM1B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KDM1B 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KDM1B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KDM1B 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidKDM1B 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM1B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KDM1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/14 Interacting proteins for KDM1B (Q8NB783 ENSP000002977924) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000227333Q96KQ73, ENSP000003973234I2D: score=1 STRING: ENSP00000397323
    EHMT2Q96KQ73I2D: score=1 
    ENSG00000206376Q96KQ73I2D: score=1 
    ENSG00000232045Q96KQ73I2D: score=1 
    ENSG00000236759Q96KQ73I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006349regulation of gene expression by genetic imprinting ISS19727073
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0008033tRNA processing ----

    KDM1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KDM1B

    1 HMDB Compound for KDM1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--

    Search CenterWatch for drugs/clinical trials and news about KDM1B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KDM1B gene: 
    NM_153042.3  

    Unigene Cluster for KDM1B:

    Lysine (K)-specific demethylase 1B
    Hs.709336  [show with all ESTs]
    Unigene Representative Sequence: NM_153042
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546309 ENST00000297792(uc003ncp.1 uc003ncq.1) ENST00000449850
    ENST00000388870(uc003nco.1) ENST00000397244(uc003ncn.1)
    miRNA
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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate KDM1B (see all 48):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-19b-2* hsa-miR-4328 hsa-miR-548k hsa-miR-624* hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidKDM1B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KDM1B
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KDM1B

    Additional mRNA sequence: 

    AJ420481.1 AK091217.1 AK125318.1 BC113093.1 BC126914.1 CR627410.1 

    7 DOTS entries:

    DT.447399  DT.121308912  DT.100736835  DT.100012828  DT.121308978  DT.95289757  DT.95361051 

    24/177 AceView cDNA sequences (see all 177):

    F04938 AA643724 BM718538 AI619902 AA805523 AW452403 BF999322 AA826271 
    AA903359 BM984039 BF110361 AI242402 AW948856 H09668 AA243512 AK125318 
    AX746856 AL120740 BF110170 AW471466 BF989881 AA332652 AW449768 BG337767 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KDM1B (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:                                                              -                 -                                       
    SP2:        -     -     -                       -     -     -     -                 -                                       
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                              -                                                         


    ECgene alternative splicing isoforms for KDM1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KDM1B expression in normal human tissues (normalized intensities)      KDM1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KDM1B Expression
    About this image


    KDM1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Medulla Oblongata
             ganglion/cranial   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             sensory organ/ear/inner ear   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Lower Urinary Tract (Urinary System)
             visceral organ   

    See KDM1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KDM1B

    SOURCE GeneReport for Unigene cluster: Hs.709336
        SABiosciences Custom PCR Arrays for KDM1B
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KDM1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KDM1B gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kdm1b5 lysine (K)-specific demethylase 1B   --   13 (24.50 cM) 47043499 
    chicken
    (Gallus gallus)
    Aves KDM1B6
    Uncharacterized protein
    62(a)
    1 ↔ 1
    2(60430400-60456085)
    lizard
    (Anolis carolinensis)
    Reptilia KDM1B6
    Uncharacterized protein
    60(a)
    1 ↔ 1
    4(56890862-56918252)
    worm
    (Caenorhabditis elegans)
    Secernentea amx-16
    spr-56
    (see all 3)
    Probable lysine-specific histone demethylase 1
    (see all 3)
    21(a)
    15(a)
    (see all 3)
    1 ↔ 1
    possible ortholog
    (see all 3)
    III(3822403-3826261)
    I(13438057-13450218)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FMS16
    Polyamine oxidase, converts spermine to spermidine...
    18(a)
    1 → many
    XIII(315377-316903)


    ENSEMBL Gene Tree for KDM1B (if available)
    TreeFam Gene Tree for KDM1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KDM1B gene
    SMOX2  PAOX2  KDM1A2  
    2 SIMAP similar genes for KDM1B using alignment to 4 protein entries:     KDM1B_HUMAN (see all proteins):
    AOF1    PAOX

    KDM1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1621 SNPs in KDM1B are shown (see all 1621)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1904442701,2
    --18157425(+) TTTTTC/GTTCAT 1 -- int10--------
    rs1417313581,2
    --18157441(+) GACCTA/GAGGAC 1 -- int10--------
    rs121920171,2
    C,F--18157463(+) AGATAT/CATAAA 1 -- int13Minor allele frequency- C:0.03CSA WA NA 240
    rs121905331,2
    --18157543(+) CTATCA/GTAAAA 1 -- int10--------
    rs595374451,2
    C,F--18157591(+) TGTTTT/CCATTT 1 -- int12Minor allele frequency- C:0.26NA EA 240
    rs768354531,2
    C,F--18157625(+) CTTTGT/CTGCAT 1 -- int11Minor allele frequency- C:0.08WA 118
    rs1816978361,2
    --18157794(+) TTCAGA/GTATTT 1 -- int10--------
    rs557993201,2
    C,F--18157813(+) ATACTT/CACATA 1 -- int12Minor allele frequency- C:0.05WA 120
    rs770952501,2
    C,F--18157866(+) GTTCAT/CGTTAT 1 -- int11Minor allele frequency- C:0.08WA 118
    rs2015023801,2
    --18157902(+) ATAAA-/TGAAG 
            
    AGATT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for KDM1B (18155560 - 18224084 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for KDM1B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv883460CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KDM1B for disorders           About MalaCards
    OMIM gene information: 613081    OMIM disorders: --


    KDM1B for disorders           About GeneDecksing


    Export disorders for KDM1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KDM1B gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with KDM1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel mammalian flavin-dependent histone demethylas e. (PubMed id 19407342)1, 3, 9 Karytinos A....Mattevi A. (2009)
    2. KDM1B is a histone H3K4 demethylase required to estab lish maternal genomic imprints. (PubMed id 19727073)1, 3 Ciccone D.N....Chen T. (2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b. (PubMed id 23266887)1 Zhang Q....Wong J. (2013)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation. (PubMed id 20670891)1 Fang R....Shi Y.G. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221656 HGNC: 21577 AceView: AOF1 Ensembl:ENSG00000165097 euGenes: HUgn221656
    ECgene: KDM1B H-InvDB: KDM1B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KDM1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KDM1B gene:
    Search GeneIP for patents involving KDM1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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