Aliases for KDM1B Gene
External Ids for KDM1B Gene
Previous HGNC Symbols for KDM1B Gene
Previous GeneCards Identifiers for KDM1B Gene
Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009]
GeneCards Summary for KDM1B Gene
KDM1B (Lysine Demethylase 1B) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include oxidoreductase activity and histone demethylase activity (H3-dimethyl-K4 specific). An important paralog of this gene is KDM1A.
UniProtKB/Swiss-Prot for KDM1B Gene
Histone demethylase that demethylates Lys-4 of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated Lys-4 of histone H3. Has no effect on tri-methylated Lys-4, mono-, di- or tri-methylated Lys-9, mono-, di- or tri-methylated Lys-27, mono-, di- or tri-methylated Lys-36 of histone H3, or on mono-, di- or tri-methylated Lys-20 of histone H4.