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KDM1B Gene

protein-coding   GIFtS: 47
GCID: GC06P018156

Lysine (K)-Specific Demethylase 1B

(Previous names: amine oxidase, flavin containing 1, chromosome 6 open reading...)
(Previous symbols: C6orf193, AOF1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lysine (K)-Specific Demethylase 1B1 2     Lysine-Specific Histone Demethylase 22 3
AOF11 2 3 5     Chromosome 6 Open Reading Frame 1931
C6orf1931 2 3     bA204B7.32
LSD22 3 5     dJ298J15.22
Amine Oxidase (Flavin Containing) Domain 11 2     Lysine-Specific Histone Demethylase 1B2
Amine Oxidase, Flavin Containing 11 2     EC 1.-.-.-3
Flavin-Containing Amine Oxidase Domain-Containing Protein 12 3     

External Ids:    HGNC: 215771   Entrez Gene: 2216562   Ensembl: ENSG000001650977   OMIM: 6130815   UniProtKB: Q8NB783   

Export aliases for KDM1B gene to outside databases

Previous GC identifer: GC06P018266


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KDM1B Gene:
Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that
regulates gene expression and chromatin function (Karytinos et al., 2009 (PubMed 19407342)).(supplied by OMIM,
Oct 2009)

GeneCards Summary for KDM1B Gene:
KDM1B (lysine (K)-specific demethylase 1B) is a protein-coding gene. GO annotations related to this gene include oxidoreductase activity and histone demethylase activity (H3-dimethyl-K4 specific). An important paralog of this gene is SMOX.

UniProtKB/Swiss-Prot: KDM1B_HUMAN, Q8NB78
Function: Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic
transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of
imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that
is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on
tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di-
or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for KDM1B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKDM1B promoter sequence
   Search Chromatin IP Primers for KDM1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KDM1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22.3

KDM1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDM1B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P018156:  view genomic region     (about GC identifiers)

Start:
18,155,560 bp from pter      End:
18,224,084 bp from pter
Size:
68,525 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KDM1B_HUMAN, Q8NB78 (See protein sequence)
Recommended Name: Lysine-specific histone demethylase 1B  
Size: 822 amino acids; 92098 Da
Cofactor: FAD (By similarity)
Subunit: Does not form a complex with RCOR1/CoREST (By similarity)
Sequence caution: Sequence=BAC03663.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Selected PDB 3D structures from and Proteopedia for KDM1B (see all 10):
4FWE (3D)        4FWF (3D)        4FWJ (3D)        4GU0 (3D)        4GU1 (3D)        4GUR (3D)    
Secondary accessions: A2A2C5 A2A2C6 Q5TGV3 Q6AI15 Q6ZUU4 Q8N258 Q96EL7
Alternative splicing: 3 isoforms:  Q8NB78-1   Q8NB78-2   Q8NB78-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KDM1B: NX_Q8NB78

Explore proteomics data for KDM1B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys378, Lys649
  • Modification sites at PhosphoSitePlus

  • See KDM1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_694587.3  
    ENSEMBL proteins: 
     ENSP00000442670   ENSP00000297792   ENSP00000405669   ENSP00000373522   ENSP00000380419  

    KDM1B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for KDM1B

     
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    antibodies-online antibodies for KDM1B (11 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KDM: Chromatin-modifying enzymes / K-demethylases

    5 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR002937 Amino_oxidase
     IPR009057 Homeodomain-like
     IPR007526 SWIRM
     IPR011124 Znf_CW

    Graphical View of Domain Structure for InterPro Entry Q8NB78

    ProtoNet protein and cluster: Q8NB78

    1 Blocks protein domain: IPB007526 SWIRM

    UniProtKB/Swiss-Prot: KDM1B_HUMAN, Q8NB78
    Domain: The SWIRM domain may act as an anchor site for a histone tail (By similarity)
    Similarity: Belongs to the flavin monoamine oxidase family
    Similarity: Contains 1 CW-type zinc finger
    Similarity: Contains 1 SWIRM domain


    Find genes that share domains with KDM1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KDM1B_HUMAN, Q8NB78
    Function: Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic
    transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of
    imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that
    is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on
    tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di-
    or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (By
    similarity)

         Enzyme Number (IUBMB): EC 1.-.-.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016491oxidoreductase activity IEA--
    GO:0034648histone demethylase activity (H3-dimethyl-K4 specific) ISS19727073
         
    Find genes that share ontologies with KDM1B           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kdm1b):
     no phenotypic analysis  other  reproductive system 

    Find genes that share phenotypes with KDM1B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kdm1btm1.1Tche for KDM1B

       genOway: Develop your customized and physiologically relevant rodent model for KDM1B

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    miRTarBase miRNAs that target KDM1B:
    hsa-mir-373-3p (MIRT002552), hsa-mir-192-5p (MIRT026955), hsa-mir-148b-3p (MIRT019487)

    Block miRNA regulation of human, mouse, rat KDM1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KDM1B (see all 48):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-19b-2* hsa-miR-4328 hsa-miR-548k hsa-miR-624* hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidKDM1B 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KDM1B_HUMAN, Q8NB78: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS19727073

    Find genes that share ontologies with KDM1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KDM1B
    Interactions:

        Search GeneGlobe Interaction Network for KDM1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for KDM1B (Q8NB783 ENSP000002977924) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000227333Q96KQ73, ENSP000003973234I2D: score=1 STRING: ENSP00000397323
    EHMT2Q96KQ73I2D: score=1 
    ENSG00000206376Q96KQ73I2D: score=1 
    ENSG00000232045Q96KQ73I2D: score=1 
    ENSG00000236759Q96KQ73I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006349regulation of gene expression by genetic imprinting ISS19727073
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0008033tRNA processing ----

    Find genes that share ontologies with KDM1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KDM1B

    1 HMDB Compound for KDM1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KDM1B gene: 
    NM_153042.3  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546309 ENST00000297792(uc003ncp.1 uc003ncq.1) ENST00000449850
    ENST00000388870(uc003nco.1) ENST00000397244(uc003ncn.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate KDM1B (see all 48):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-19b-2* hsa-miR-4328 hsa-miR-548k hsa-miR-624* hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidKDM1B 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat KDM1B

    Selected AceView cDNA sequences (see all 177):

    BM718538 AI888253 BM984039 H09668 AA643724 AK125318 AK091217 AW948856 
    AA426219 AI318367 BF448550 AI619902 AX746856 AI367920 BF110170 BF110361 
    AW471466 BF999322 AI241406 AA331633 AW009229 BG337767 AA332652 AA384304 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KDM1B (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:                                                              -                 -                                       
    SP2:        -     -     -                       -     -     -     -                 -                                       
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                              -                                                         


    ECgene alternative splicing isoforms for KDM1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KDM1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KDM1B Expression
    About this image


    KDM1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
     
     Ovary (Reproductive System)
             Secondary follicles
     
     Neural Tube (Nervous System)
             Diencephalon
    KDM1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KDM1B Protein Expression
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KDM1B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kdm1b5 lysine (K)-specific demethylase 1B   --   13 (24.50 cM) 47043499 
    chicken
    (Gallus gallus)
    Aves KDM1B6
    lysine (K)-specific demethylase 1B
    62(a)
    1 ↔ 1
    2(60430400-60456085)
    lizard
    (Anolis carolinensis)
    Reptilia KDM1B6
    lysine (K)-specific demethylase 1B
    59(a)
    1 ↔ 1
    4(56890862-56918252)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-7o6.36
    si:dkey-7o6.3
    22(a)
    many ↔ many
    8(15756500-15767567) ENSDARG00000043403
    worm
    (Caenorhabditis elegans)
    Secernentea amx-16
    lsd-16
    (see all 3)
    Protein LSD-1 (lsd-1) mRNA, complete cds
    (see all 3)
    26(a)
    17(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    III(3822403-3826261) WBGene00000137
    X(11948852-11951940) WBGene00011615


    ENSEMBL Gene Tree for KDM1B (if available)
    TreeFam Gene Tree for KDM1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KDM1B gene
    SMOX2  PAOX2  KDM1A2  
    2 SIMAP similar genes for KDM1B using alignment to 4 protein entries:     KDM1B_HUMAN (see all proteins):
    AOF1    PAOX

    Find genes that share paralogs with KDM1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KDM1B (see all 1621)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1904442701,2
    --18157425(+) TTTTTC/GTTCAT 1 -- int10--------
    rs1417313581,2
    --18157441(+) GACCTA/GAGGAC 1 -- int10--------
    rs121920171,2
    C,F--18157463(+) AGATAT/CATAAA 1 -- int13Minor allele frequency- C:0.03CSA WA NA 240
    rs121905331,2
    --18157543(+) CTATCA/GTAAAA 1 -- int10--------
    rs595374451,2
    C,F--18157591(+) TGTTTT/CCATTT 1 -- int12Minor allele frequency- C:0.26NA EA 240
    rs768354531,2
    C,F--18157625(+) CTTTGT/CTGCAT 1 -- int11Minor allele frequency- C:0.08WA 118
    rs1816978361,2
    --18157794(+) TTCAGA/GTATTT 1 -- int10--------
    rs557993201,2
    C,F--18157813(+) ATACTT/CACATA 1 -- int12Minor allele frequency- C:0.05WA 120
    rs770952501,2
    C,F--18157866(+) GTTCAT/CGTTAT 1 -- int11Minor allele frequency- C:0.08WA 118
    rs2015023801,2
    --18157902(+) ATAAA-/TGAAG 
            
    AGATT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for KDM1B (18155560 - 18224084 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for KDM1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv883460CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KDM1B
    DNA2.0 Custom Variant and Variant Library Synthesis for KDM1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613081    OMIM disorders: --


    Find genes that share disorders with KDM1B           About GenesLikeMe


    Export disorders for KDM1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KDM1B gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with KDM1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel mammalian flavin-dependent histone demethylase. (PubMed id 19407342)1, 3, 9 Karytinos A....Mattevi A. (J. Biol. Chem. 2009)
    2. KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. (PubMed id 19727073)1, 3 Ciccone D.N....Chen T. (Nature 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b. (PubMed id 23266887)1 Zhang Q....Wong J. (Cell Res. 2013)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 221656 HGNC: 21577 AceView: AOF1 Ensembl:ENSG00000165097 euGenes: HUgn221656
    ECgene: KDM1B H-InvDB: KDM1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KDM1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KDM1B gene:
    Search GeneIP for patents involving KDM1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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