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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KDM1B Gene

protein-coding GIFtS: 46
GCID: GC06P018156

lysine (K)-specific demethylase 1B

(Previous names: amine oxidase, flavin containing 1, chromosome 6 open reading...)
(Previous symbols: C6orf193, AOF1)

Search for KDM1B
in

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lysine (K)-Specific Demethylase 1B¹ ²		Flavin-Containing Amine Oxidase Domain-Containing Protein 1² ³
AOF1¹ ² ³ ⁵		Lysine-Specific Histone Demethylase 2² ³
LSD2¹ ² ³ ⁵		FLJ33898¹
C6orf193¹ ² ³		FLJ34109¹
Amine Oxidase (Flavin Containing) Domain 1¹ ²		FLJ43328¹
Amine Oxidase, Flavin Containing 1¹ ²		Chromosome 6 Open Reading Frame 193¹
BA204B7.3¹		Lysine-Specific Histone Demethylase 1B²
DJ298J15.2¹		EC 1.-.-.-³

External Ids:	HGNC: 21577¹	Entrez Gene: 221656²	Ensembl: ENSG00000165097⁷	OMIM: 613081⁵	UniProtKB: Q8NB78³

Export aliases for KDM1B gene to outside databases

Previous GC identifer: GC06P018266

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KDM1B:

Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that

regulates gene expression and chromatin function (Karytinos et al., 2009 (PubMed 19407342)).(supplied by OMIM, Oct

2009)

UniProtKB/Swiss-Prot: KDM1B_HUMAN, Q8NB78

Function: Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional

activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes

during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently

hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4',

mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of

histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for KDM1B
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KDM1B promoter sequence

Search SABiosciences Chromatin IP Primers for KDM1B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDM1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3 Ensembl cytogenetic band: 6p22.3 HGNC cytogenetic band: 6p22.3

KDM1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDM1B gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P018156: view genomic region (about GC identifiers)

Start:	18,155,560 bp from pter	End:	18,224,084 bp from pter
Size:	68,525 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KDM1B_HUMAN, Q8NB78 (See protein sequence)

Recommended Name: Lysine-specific histone demethylase 1B

Size: 822 amino acids; 92098 Da

Cofactor: FAD (By similarity)

Subunit: Does not form a complex with RCOR1/CoREST (By similarity)

Subcellular location: Nucleus (By similarity)

Sequence caution: Sequence=BAC03663.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

6/10 PDB 3D structures from and Proteopedia for KDM1B (see all 10):

4FWE (3D)

4FWF (3D)

4FWJ (3D)

4GU0 (3D)

4GU1 (3D)

4GUR (3D)

Secondary accessions: A2A2C5 A2A2C6 Q5TGV3 Q6AI15 Q6ZUU4 Q8N258 Q96EL7

Alternative splicing: 3 isoforms: Q8NB78-1 Q8NB78-2 Q8NB78-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KDM1B: NX_Q8NB78

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NB78

KDM1B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_694587.3

ENSEMBL proteins:

ENSP00000297792 ENSP00000373521 ENSP00000405669 ENSP00000373522 ENSP00000380419

ENSP00000442670

Human Recombinant Protein Products for KDM1B:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KDM1B

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	19727073

KDM1B for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for KDM1B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KDM1B for domains About GeneDecksing

5 InterPro domains/families:

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR002937 Amino_oxidase

IPR009057 Homeodomain-like

IPR007526 SWIRM

IPR011124 Znf_CW

Graphical View of Domain Structure for InterPro Entry Q8NB78

ProtoNet protein and cluster: Q8NB78

1 Blocks protein family: IPB007526 SWIRM

UniProtKB/Swiss-Prot: KDM1B_HUMAN, Q8NB78

Domain: The SWIRM domain may act as an anchor site for a histone tail (By similarity)

Similarity: Belongs to the flavin monoamine oxidase family

Similarity: Contains 1 CW-type zinc finger

Similarity: Contains 1 SWIRM domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: KDM1B_HUMAN, Q8NB78

Function: Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional

activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes

during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently

hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4',

mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of

histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (By similarity)

Enzyme Number (IUBMB): EC 1.-.-.-¹

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)	ISS	19727073
GO:0034649	histone demethylase activity (H3-monomethyl-K4 specific)	ISS	19727073

KDM1B for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Kdm1b):

no phenotypic analysis

other

reproductive system

KDM1B for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Kdm1b^tm1.1Tche for KDM1B

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for KDM1B

miRNA Products:		OriGene 3'-UTR Clone: KDM1B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KDM1B
		8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate KDM1B (see all 48):
		hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-19b-2* hsa-miR-4328 hsa-miR-548k hsa-miR-624* hsa-miR-519a

		SwitchGear 3'UTR luciferase reporter plasmid: KDM1B 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM1B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KDM1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/10 Interacting proteins for KDM1B (Q8NB78³ ENSP00000297792⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAP1	Q92560³, ENSP00000417132⁴	I2D: score=2 STRING: ENSP00000417132
CCNT1	O60563³, ENSP00000261900⁴	I2D: score=1 STRING: ENSP00000261900
SMC1A	Q14683³, ENSP00000323421⁴	I2D: score=1 STRING: ENSP00000323421
WDR5	P61964³, ENSP00000351446⁴	I2D: score=1 STRING: ENSP00000351446
WHSC1L1	Q9BZ95³, ENSP00000313983⁴	I2D: score=1 STRING: ENSP00000313983

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006349	regulation of gene expression by genetic imprinting	ISS	19727073
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0034720	histone H3-K4 demethylation	ISS	19727073

KDM1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KDM1B

1 HMDB Compound for KDM1B About this table

Compound	Synonyms	CAS #	PubMed Ids
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--

Search CenterWatch for drugs/clinical trials and news about KDM1B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KDM1B gene:

NM_153042.3

Unigene Cluster for KDM1B:

Lysine (K)-specific demethylase 1B

Hs.709336 [show with all ESTs]

Unigene Representative Sequence: NM_153042

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000297792(uc003ncp.1 uc003ncq.1) ENST00000388869 ENST00000449850

ENST00000388870(uc003nco.1) ENST00000397244(uc003ncn.1) ENST00000546309

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		8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate KDM1B (see all 48):
		hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-19b-2* hsa-miR-4328 hsa-miR-548k hsa-miR-624* hsa-miR-519a

		SwitchGear 3'UTR luciferase reporter plasmid: KDM1B 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KDM1B (see all 4) OriGene shRNA RFP: KDM1B OriGene siRNA: KDM1B
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Additional cDNA sequence:

AJ420481.1 AK091217.1 AK125318.1 BC113093.1 BC126914.1 CR627410.1

7 DOTS entries:

DT.447399 DT.121308912 DT.100736835 DT.100012828 DT.121308978 DT.95289757 DT.95361051

24/177 AceView cDNA sequences (see all 177):

CB243653 F04938 AA243512 AK091217 AA384304 T17259 AA643724 BG337767

BM720576 BF110361 AA332652 H09668 AI619902 AA331633 AX746856 BF448550

AL120740 AI242402 BF999322 AA426219 AA805523 AW452403 AA903359 AI318367

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KDM1B (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16a	·	16b
SP1:																					-						-
SP2:			-		-		-								-		-		-		-						-
SP3:
SP4:
SP5:																					-

ECgene alternative splicing isoforms for KDM1B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KDM1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

KDM1B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Secondary follicles (Primary Cell)

Ovary, Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KDM1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KDM1B

SOURCE GeneReport for Unigene cluster: Hs.709336

SABiosciences Custom PCR Arrays for KDM1B

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for KDM1B gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KDM1B⁶	Uncharacterized protein	58(a)	1 ↔ 1	2(61458886-61474257)
lizard (Anolis carolinensis)	Reptilia	KDM1B⁶	--	55(a)	1 ↔ 1	4(56890862-56917700)
worm (Caenorhabditis elegans)	Secernentea	amx-1⁶ spr-5⁶ (see all 3)	Probable lysine-specific histone demethylase 1 (see all 3)	22(a) 15(a) (see all 3)	1 ↔ 1 possible ortholog (see all 3)	III(3822385-3826243) I(13438046-13450207)
thale cress (Arabidopsis thaliana)	eudicotyledons	ATPAO1⁶	Polyamine oxidase 1	21(a)	possible ortholog	5(4420069-4423033)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	polyamine oxidase precursor, putative amine oxidase, flavin-containing, domain containin... (see all 4)	23(a) 21(a) (see all 4)	possible ortholog possible ortholog (see all 4)	9(12145398-12147535) 9(12165726-12175969)

ENSEMBL Gene Tree for KDM1B (if available)
TreeFam Gene Tree for KDM1B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KDM1B gene

SMOX² PAOX² KDM1A²

2 SIMAP similar genes for KDM1B using alignment to 4 protein entries: KDM1B_HUMAN (see all proteins):

AOF1 PAOX

KDM1B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190444270^1,2		--	18157425(+)	`TTTTTC/GTTCAT`	1	--	int¹		0	--	--	--	--
rs141731358^1,2		--	18157441(+)	`GACCTA/GAGGAC`	1	--	int¹		0	--	--	--	--
rs12192017^1,2		--	18157463(+)	`AGATAT/CATAAA`	1	--	int¹		3		CSA WA NA	240
rs12190533^1,2		--	18157543(+)	`CTATCA/GTAAAA`	1	--	int¹		0	--	--	--	--
rs59537445^1,2	C,F	--	18157591(+)	`TGTTTT/CCATTT`	1	--	int¹		2		NA EA	240
rs76835453^1,2	F	--	18157625(+)	`CTTTGT/CTGCAT`	1	--	int¹		1		WA	118
rs181697836^1,2		--	18157794(+)	`TTCAGA/GTATTT`	1	--	int¹		0	--	--	--	--
rs55799320^1,2	C	--	18157813(+)	`ATACTT/CACATA`	1	--	int¹		2		WA	120
rs77095250^1,2	F	--	18157866(+)	`GTTCAT/CGTTAT`	1	--	int¹		1		WA	118
rs201502380^1,2		--	18157902(+)	`ATAAA-/TGAAG AGATT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KDM1B (18155560 - 18224084 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KDM1B: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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KDM1B for disorders About MalaCards

KDM1B for disorders About GeneDecksing

OMIM gene information: 613081 OMIM disorders: --

Export disorders for KDM1B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KDM1B gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with KDM1B)

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A novel mammalian flavin-dependent histone demethylas e. (PubMed id 19407342)^{1, 3, 9} Karytinos A....Mattevi A. (2009)
KDM1B is a histone H3K4 demethylase required to estab lish maternal genomic imprints. (PubMed id 19727073)^{1, 3} Ciccone D.N....Chen T. (2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation. (PubMed id 20670891)¹ Fang R....Shi Y.G. (2010)
The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. (PubMed id 20805357)¹ Yu H....Affar e.l. .B. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 221656	HGNC: 21577	AceView: AOF1	Ensembl:ENSG00000165097	euGenes: HUgn221656
ECgene: KDM1B	H-InvDB: KDM1B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KDM1B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KDM1B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KDM1B gene:
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lysine (K)-specific demethylase 1B

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lysine (K)-specific demethylase 1B

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