KDM1A Gene
protein-coding GIFtS: 60
GCID: GC01P023347
|
|
lysine (K)-specific demethylase 1A(Previous names: amine oxidase (flavin containing) domain 2, lysine (K)-specific...)
(Previous symbols: AOF2, KDM1)
| |
Aliases
for KDM1A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Lysine (K)-Specific Demethylase 1A1 2 | | Lysine (K)-Specific Demethylase 11 2 | | AOF21 2 3 5 | | Flavin-Containing Amine Oxidase Domain-Containing Protein 22 3 | | LSD11 2 3 5 | | BRAF35-HDAC Complex Protein BHC1102 3 | | KDM11 2 3 | | FAD-Binding Protein BRAF35-HDAC Complex, 110 KDa Subunit2 | | BHC1101 2 5 | | Lysine-Specific Histone Demethylase 12 | | KIAA06011 3 5 | | Lysine-Specific Histone Demethylase 1A2 | | Amine Oxidase (Flavin Containing) Domain 21 2 | | EC 1.-.-.-3 |
Export aliases for KDM1A gene to outside databasesPrevious GC identifers: GC01P023220 GC01P021590 |
Summaries
for KDM1A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KDM1A:
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. Thisprotein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histonedemethylase. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Apr 2009)
UniProtKB/Swiss-Prot: KDM1A_HUMAN, O60341Function: Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, therebyacting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generatethe corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, aspecific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2)H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomesand requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor(ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, aspecific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, whichmediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me,prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which preventsinteraction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates andstabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDACcomplex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineageblood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8.Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7
|
Genomic Views
for KDM1A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for KDM1A
Other transcription factors
Search SABiosciences Chromatin IP Primers for KDM1A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDM1A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.12 Ensembl cytogenetic band: 1p36.12 HGNC cytogenetic band: 1p36.12KDM1A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P023347: view genomic region
(about GC identifiers)
Start:
|
23,345,941 bp from pter |
End:
|
23,410,184 bp from pter |
Size:
|
64,244 bases |
Orientation:
|
plus strand |
|
Proteins
for KDM1A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KDM1A_HUMAN, O60341 (See
protein sequence)Recommended Name: Lysine-specific histone demethylase 1A Size: 852 amino acids; 92903 Da
Cofactor: FAD
Subunit: Component of a RCOR/GFI/KDM1A/HDAC complex. Interacts directly with GFI1 and GFI1B (By similarity). Componentof a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B, KDM1A, RCOR1 and PHF21A. The BHC complex mayalso contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. In the complex, RCOR1/CoREST strongly enhances the demethylaseactivity and protects it from the proteasome while PHF21A/BHC80 inhibits the demethylase activity. Interacts with theandrogen receptor (AR). Interacts with ASXL1. Interacts with SNAI1 (via SNAG domain)
Subcellular location: Nucleus
Sequence caution: Sequence=BAA25527.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
6/22 PDB 3D structures from  and Proteopedia  for KDM1A (see all 22):2COM (3D)
2DW4 (3D)
2EJR (3D)
2H94 (3D)
2HKO (3D)
2IW5 (3D)
Secondary accessions: A8MWP9 Q5TH94 Q5TH95 Q86VT7 Q8IXK4 Q8NDP6 Q8TAZ3 Q96AW4Alternative splicing: 2 isoforms: O60341-1 O60341-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KDM1A: NX_O60341
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60341
KDM1A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001009999.1 NP_055828.2
ENSEMBL proteins: ENSP00000349049 ENSP00000383042 ENSP00000439072 Reactome Protein details: O60341
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
KDM1A for ontologies About GeneDecksing
KDM1A Antibody Products:
Assay Products for KDM1A: |
Protein
Domains /
Families
for KDM1A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KDM1A for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O60341ProtoNet protein and cluster: O60341 1 Blocks protein family: IPB007526 SWIRM
UniProtKB/Swiss-Prot: KDM1A_HUMAN, O60341Domain: The SWIRM domain may act as an anchor site for a histone tailSimilarity: Belongs to the flavin monoamine oxidase familySimilarity: Contains 1 SWIRM domain |
Function
for KDM1A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KDM1A_HUMAN, O60341Function: Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, therebyacting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generatethe corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, aspecific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2)H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomesand requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor(ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, aspecific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, whichmediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me,prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which preventsinteraction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates andstabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDACcomplex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineageblood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8.Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7Biophysicochemical properties: Kinetic parameters: KM=3.0 uM for H3 monomethyl-K4; KM=4.2 uM for H3 dimethyl-K4; KM=3.9uM for H3 monomethyl-K4-monomethyl-K9; KM=17.5 uM for monomethyl-K4-acetyl-K9;Enzyme Number (IUBMB): EC 1.-.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KDM1A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KDM1A (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): KDM1A (NM_015013) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KDM1A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDM1A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM1A |
Gene Ontology (GO): 5/19 molecular function terms (GO ID links to tree view) (see all 19): About this table
KDM1A for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for KDM1A:
Animal Models:
Mouse knock-outs for KDM1A: Kdm1atm1.2Tche Kdm1atm1.2Rsd
7 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Kdm1a):
KDM1A for phenotypes About GeneDecksing
|
Pathways & Interactions
for KDM1A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Chromatin Regulation / Acetylation | | | 2 | Factors involved in megakaryocyte development and platelet production | | | 3 | Androgen receptor signaling pathway | | | 4 | Notch-mediated HES/HEY network | | | 5 | Notch signaling pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for KDM1A
1 
Cell Signaling Technology (CST) Pathway for KDM1A
4  BioSystems Pathways for KDM1A
2 
Reactome Pathways for KDM1A
KDM1A for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KDM1A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/872 Interacting proteins for KDM1A (O603411, 2, 3 ENSP000003490494) via UniProtKB, MINT, STRING, and/or I2D (see all 872)About this table
Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
ISS | -- | | GO:0001701 | in utero embryonic development |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
IMP | 16079795 |
KDM1A for ontologies About GeneDecksing
|
Drugs & Compounds
for KDM1A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
KDM1A for compounds About GeneDecksing
 Compounds for KDM1A available from Tocris Bioscience About this table
1 HMDB Compound for KDM1A About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| FAD | 1H-Purin-6-amine flavin dinucleotide (see all 21) | 146-14-5 | -- |
9 Novoseek chemical compound relationships for KDM1A gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tranylcypromine |
75.2 |
17 |
17367163 (3), 18039463 (2), 17569509 (2) |
| lysine |
69.3 |
26 |
16567619 (1), 19208907 (1), 19407342 (1), 17392792 (1) (see all 17) |
| flavin |
57.1 |
5 |
17511474 (2), 18039463 (1) |
| amine |
53.5 |
14 |
17511474 (2), 19624733 (2), 19407342 (1), 20164337 (1) (see all 9) |
| flavin-adenine dinucleotide |
48.6 |
6 |
17529991 (1), 17569509 (1) |
| salicylic acid |
14.1 |
5 |
11844114 (3), 15347794 (1) |
| testosterone |
1.02 |
15 |
16079795 (8), 17277772 (5) |
| oxygen |
0 |
2 |
15811342 (1), 11595797 (1) |
| superoxide |
0 |
2 |
8791589 (1), 11595797 (1) |
Search CenterWatch for drugs/clinical trials and news about KDM1A
|
Transcripts
for KDM1A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KDM1A gene (2 alternative transcripts): NM_001009999.2 NM_015013.3 Unigene Cluster for KDM1A: Lysine (K)-specific demethylase 1A Hs.591518 [show with all ESTs]Unigene Representative Sequence: NM_0010099996 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000356634(uc001bgi.2) ENST00000400181(uc001bgj.2) ENST00000481879
ENST00000465864 ENST00000494920 ENST00000542151
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KDM1A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KDM1A (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): KDM1A (NM_015013) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KDM1A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDM1A |
Additional cDNA sequence: AB011173.1 AK290328.1 AL833812.1 BC016639.1 BC025362.1 BC040194.2 BC048134.1 20 DOTS entries: DT.445541 DT.75168215 DT.101965255 DT.97807163 DT.100029753 DT.91810793 DT.91855964 DT.91864063 DT.100792121 DT.102833397 DT.100792124 DT.95305991 DT.92409945 DT.95118653 DT.95305995 DT.100029751 DT.100029754 DT.92398041 DT.95219935 DT.95326557 24/350 AceView cDNA sequences (see all 350): AW138979 CA489878 AL040690 BC025362 BU508631 BQ938129 CD518918 CF135181 BQ898499 AA337953 BQ434897 BE251405 BM717209 AI298510 BQ218420 CN482870 AA429058 T08376 BF969563 BU521265 BE256979 BQ214471 BU184343 CB131888
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KDM1A (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | - | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21 |
|---|
|
| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for KDM1A
|
Expression
for KDM1A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KDM1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAGGAAGGC
About this image
See KDM1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KDM1A
SOURCE GeneReport for Unigene cluster: Hs.591518
UniProtKB/Swiss-Prot: KDM1A_HUMAN, O60341Tissue specificity: Ubiquitously expressed
SABiosciences Expression via Pathway-Focused PCR Array including KDM1A: | Epigenetic Chromatin Modification Enzymes in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KDM1A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KDM1A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KDM1A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KDM1A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM1A |
Orthologs
for KDM1A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KDM1A gene from 8/30 species (see all 30) About this table
ENSEMBL Gene Tree for KDM1A (if available)
TreeFam Gene Tree for KDM1A (if available) |
Paralogs
for KDM1A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KDM1A gene
- KDM1B2 SMOX2 PAOX2
2 SIMAP similar genes for KDM1A using alignment to 2 protein entries: KDM1A_HUMAN (see all proteins):PAOX AOF1
KDM1A for paralogs About GeneDecksing
|
Genomic Variants
for KDM1A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KDM1A (23345941 - 23410184 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KDM1A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KDM1A |
|
Disorders
/ Diseases
for KDM1A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KDM1A for disorders About GeneDecksing
OMIM gene information: 609132
OMIM disorders: --
19  diseases for KDM1A: About MalaCardsmalignant peripheral nerve sheath tumor differentiating neuroblastoma synovial sarcoma multiple myeloma
myeloma rhabdomyosarcoma hyperglycemia hematopoiesis
sarcoma hepatocellular carcinoma neuroblastoma nasopharyngitis
retinoblastoma prostate cancer breast cancer prostatitis
schizophrenia carcinoma neuronitis
3 Novoseek disease relationships for KDM1A gene About this table
Export disorders for KDM1A gene to outside databases
|
Publications
for KDM1A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KDM1A gene, integrated from 9 sources (see all 170):
(articles sorted by number of sources associating them with KDM1A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. (PubMed id 12493763)1, 2, 3, 9 Hakimi M.A....Shiekhattar R. (2003)
- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (1998)
- Crystal structure of human histone lysine-specific demethylase 1 (LSD1). (PubMed id 16956976)1, 2, 9 Chen Y.... Lei M. (2006)
- LSD1 demethylates repressive histone marks to promote androgen- receptor-dependent transcription. (PubMed id 16079795)1, 2, 9 Metzger E.... Schuele R. (2005)
- Regulation of LSD1 histone demethylase activity by its associated factors. (PubMed id 16140033)1, 2, 9 Shi Y.-J.... Shi Y. (2005)
- Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process. (PubMed id 15811342)1, 2, 9 Forneris F.... Battaglioli E. (2005)
- ASXL1 represses retinoic acid receptor-mediated trans cription through associating with HP1 and LSD1. (PubMed id 19880879)1, 2, 9 Lee S.W....Um S.J. (2010)
- Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. (PubMed id 16885027)1, 2, 9 Yang M.... Yu H. (2006)
- An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. (PubMed id 16079794)1, 2, 9 Lee M.G.... Shiekhattar R. (2005)
- p53 is regulated by the lysine demethylase LSD1. (PubMed id 17805299)1, 2, 9 Huang J.... Berger S.L. (2007)
|
External Searches for KDM1A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KDM1A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KDM1A gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KDM1A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KDM1A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KDM1A gene:
Search GeneIP for patents involving KDM1A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KDM1A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for KDM1A | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KDM1A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KDM1A | | | OriGene Protein Over-expression Lysate for KDM1A | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for KDM1A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KDM1A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KDM1A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KDM1A | | OriGene Custom Protein Services for KDM1A | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KDM1A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KDM1A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDM1A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KDM1A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KDM1A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KDM1A |
| |
 |  |  |  | |
| | Antibodies & Assays for KDM1A (LSD1) |
| | | | Tocris compounds for KDM1A |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | KDM1A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDM1A |
|  |  |  | | | | ThermoFisher Antibody for KDM1A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDM1A |
|
|
|
|
