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Aliases for KDELR3 Gene

Aliases for KDELR3 Gene

  • KDEL Endoplasmic Reticulum Protein Retention Receptor 3 2 3 4 5
  • KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 3 2 3
  • KDEL Receptor 3 3 4
  • ER Lumen Protein Retaining Receptor 3 3
  • ERD2L3 3

External Ids for KDELR3 Gene

Previous GeneCards Identifiers for KDELR3 Gene

  • GC22P035478
  • GC22P037107
  • GC22P037189
  • GC22P038864
  • GC22P021830

Summaries for KDELR3 Gene

Entrez Gene Summary for KDELR3 Gene

  • This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for KDELR3 Gene

KDELR3 (KDEL Endoplasmic Reticulum Protein Retention Receptor 3) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Unfolded Protein Response (UPR). GO annotations related to this gene include ER retention sequence binding. An important paralog of this gene is KDELR2.

UniProtKB/Swiss-Prot for KDELR3 Gene

  • Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity).

Gene Wiki entry for KDELR3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KDELR3 Gene

Genomics for KDELR3 Gene

Regulatory Elements for KDELR3 Gene

Promoters for KDELR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KDELR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for KDELR3 Gene

Chromosome:
22
Start:
38,468,062 bp from pter
End:
38,483,447 bp from pter
Size:
15,386 bases
Orientation:
Plus strand

Genomic View for KDELR3 Gene

Genes around KDELR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KDELR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KDELR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KDELR3 Gene

Proteins for KDELR3 Gene

  • Protein details for KDELR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43731-ERD23_HUMAN
    Recommended name:
    ER lumen protein-retaining receptor 3
    Protein Accession:
    O43731
    Secondary Accessions:
    • A8K7T7
    • B8ZZ26
    • O95557
    • Q4V750
    • Q4V767
    • Q53FP4
    • Q53GK1

    Protein attributes for KDELR3 Gene

    Size:
    214 amino acids
    Molecular mass:
    25027 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KDELR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KDELR3 Gene

Proteomics data for KDELR3 Gene at MOPED

Post-translational modifications for KDELR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KDELR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KDELR3 Gene

Domains & Families for KDELR3 Gene

Protein Domains for KDELR3 Gene

Suggested Antigen Peptide Sequences for KDELR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43731

UniProtKB/Swiss-Prot:

ERD23_HUMAN :
  • Belongs to the ERD2 family.
Family:
  • Belongs to the ERD2 family.
genes like me logo Genes that share domains with KDELR3: view

No data available for Gene Families for KDELR3 Gene

Function for KDELR3 Gene

Molecular function for KDELR3 Gene

GENATLAS Biochemistry:
endoplasmic reticulum protein retention receptor 3 (Lys-Asp-Glu-Leu),S cerevisiae ERD2 ortholog,allowing the retrieval of proteins from Golgi complex to ER,mimicking the brefeldin A (BFA)-like phenotype,when overexpressed
UniProtKB/Swiss-Prot Function:
Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity).
genes like me logo Genes that share phenotypes with KDELR3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KDELR3 Gene

Localization for KDELR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDELR3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KDELR3 Gene COMPARTMENTS Subcellular localization image for KDELR3 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
cytoskeleton 1
cytosol 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for KDELR3 Gene

Pathways & Interactions for KDELR3 Gene

genes like me logo Genes that share pathways with KDELR3: view

Gene Ontology (GO) - Biological Process for KDELR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006621 protein retention in ER lumen IEA --
GO:0015031 protein transport IEA --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with KDELR3: view

No data available for SIGNOR curated interactions for KDELR3 Gene

Drugs & Compounds for KDELR3 Gene

No Compound Related Data Available

Transcripts for KDELR3 Gene

Unigene Clusters for KDELR3 Gene

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KDELR3 Gene

No ASD Table

Relevant External Links for KDELR3 Gene

GeneLoc Exon Structure for
KDELR3
ECgene alternative splicing isoforms for
KDELR3

Expression for KDELR3 Gene

mRNA expression in normal human tissues for KDELR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KDELR3 Gene

This gene is overexpressed in Oral epithelium (29.3) and Bone (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KDELR3 Gene



SOURCE GeneReport for Unigene cluster for KDELR3 Gene Hs.745072

genes like me logo Genes that share expression patterns with KDELR3: view

Protein tissue co-expression partners for KDELR3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KDELR3 Gene

Orthologs for KDELR3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KDELR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KDELR3 35
  • 99.38 (n)
  • 99.53 (a)
KDELR3 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KDELR3 36
  • 93 (a)
OneToOne
KDELR3 35
  • 93.93 (n)
  • 98.6 (a)
dog
(Canis familiaris)
Mammalia KDELR3 35
  • 93.61 (n)
  • 99.07 (a)
KDELR3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kdelr3 16
Kdelr3 35
  • 88.16 (n)
  • 92.52 (a)
Kdelr3 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KDELR3 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kdelr3 35
  • 88.63 (n)
  • 92.52 (a)
chicken
(Gallus gallus)
Aves KDELR3 36
  • 75 (a)
OneToOne
KDELR3 35
  • 80.84 (n)
  • 88.79 (a)
lizard
(Anolis carolinensis)
Reptilia KDELR3 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64313 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kdelr3 35
  • 74.77 (n)
  • 87.38 (a)
Str.8306 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
kdelr3 35
  • 72.12 (n)
  • 77.57 (a)
kdelr3 36
  • 74 (a)
OneToMany
KDELR3 (2 of 2) 36
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta KdelR 36
  • 62 (a)
OneToMany
KdelR 37
  • 66 (a)
worm
(Caenorhabditis elegans)
Secernentea C28H8.4 37
  • 61 (a)
C28H8.4 36
  • 60 (a)
ManyToMany
erd-2 36
  • 57 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERD2 36
  • 46 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2912 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 71 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
Species with no ortholog for KDELR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KDELR3 Gene

ENSEMBL:
Gene Tree for KDELR3 (if available)
TreeFam:
Gene Tree for KDELR3 (if available)

Paralogs for KDELR3 Gene

Paralogs for KDELR3 Gene

(2) SIMAP similar genes for KDELR3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KDELR3: view

Variants for KDELR3 Gene

Sequence variations from dbSNP and Humsavar for KDELR3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs12004 - 38,481,456(+) GTATG(G/T)GACCA reference, missense
rs138419 -- 38,467,001(+) ATGGC(C/T)TGAGC upstream-variant-2KB
rs138420 -- 38,467,933(+) AGAAG(-/C)CCCCC upstream-variant-2KB
rs138424 -- 38,473,975(+) TCTCA(-/AAAAAAG)AAAAA intron-variant
rs401933 -- 38,479,544(+) TAGGC(C/T)GGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KDELR3 Gene

Variant ID Type Subtype PubMed ID
nsv834195 CNV Loss 17160897
dgv4970n71 CNV Loss 21882294
nsv817994 CNV Gain 17921354
nsv915066 CNV Loss 21882294

Variation tolerance for KDELR3 Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.38; 88.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KDELR3 Gene

HapMap Linkage Disequilibrium report
KDELR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KDELR3 Gene

Disorders for KDELR3 Gene

Relevant External Links for KDELR3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KDELR3

No disorders were found for KDELR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KDELR3 Gene

Publications for KDELR3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3
  4. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PMID: 12529303) Collins J.E. … Dunham I. (Genome Res. 2003) 3
  5. Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis. (PMID: 11827452) Jia L. … Francomano C.A. (Genomics 2002) 3

Products for KDELR3 Gene

Sources for KDELR3 Gene

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