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KDELR3 Gene

protein-coding   GIFtS: 52
GCID: GC22P038864

KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention...

  Search for KDELR3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor
31 2
KDEL Endoplasmic Reticulum Protein Retention Receptor 32 3
KDEL Receptor 32 3
ERD2L32
ER Lumen Protein Retaining Receptor 32

External Ids:    HGNC: 63061   Entrez Gene: 110152   Ensembl: ENSG000001001967   UniProtKB: O437313   

Export aliases for KDELR3 gene to outside databases

Previous GC identifers: GC22P035478 GC22P037107 GC22P037189 GC22P021830


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KDELR3 Gene:
This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of
resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal
cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is
dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and
his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the
tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single
gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting
the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified.
Alternate splicing results in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for KDELR3 Gene:
KDELR3 (KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3) is a protein-coding gene. GO annotations related to this gene include ER retention sequence binding. An important paralog of this gene is KDELR1.

UniProtKB/Swiss-Prot: ERD23_HUMAN, O43731
Function: Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the
luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor
recognizes K-D-E-L (By similarity)

Gene Wiki entry for KDELR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the KDELR3 gene promoter:
         Max1   AP-1   ATF-2   Tal-1beta   POU2F1a   c-Jun   ITF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKDELR3 promoter sequence
   Search Chromatin IP Primers for KDELR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KDELR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13

KDELR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KDELR3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P038864:  view genomic region     (about GC identifiers)

Start:
38,864,067 bp from pter      End:
38,879,452 bp from pter
Size:
15,386 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ERD23_HUMAN, O43731 (See protein sequence)
Recommended Name: ER lumen protein retaining receptor 3  
Size: 214 amino acids; 25027 Da
Secondary accessions: A8K7T7 B8ZZ26 O95557 Q4V750 Q4V767 Q53FP4 Q53GK1
Alternative splicing: 2 isoforms:  O43731-1   O43731-2   

Explore the universe of human proteins at neXtProt for KDELR3: NX_O43731

Explore proteomics data for KDELR3 at MOPED


See KDELR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_006846.1  NP_057839.1  

ENSEMBL proteins: 
 ENSP00000216014   ENSP00000386918  
Reactome Protein details: O43731

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Search eBioscience for ELISAs for KDELR3 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR000133 ER_ret_rcpt

Graphical View of Domain Structure for InterPro Entry O43731

ProtoNet protein and cluster: O43731

1 Blocks protein domain: IPB000133 ER lumen protein retaining receptor

UniProtKB/Swiss-Prot: ERD23_HUMAN, O43731
Similarity: Belongs to the ERD2 family


Find genes that share domains with KDELR3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ERD23_HUMAN, O43731
Function: Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the
luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor
recognizes K-D-E-L (By similarity)

     Genatlas biochemistry entry for KDELR3:
endoplasmic reticulum protein retention receptor 3 (Lys-Asp-Glu-Leu),S cerevisiae ERD2 ortholog,allowing the
retrieval of proteins from Golgi complex to ER,mimicking the brefeldin A (BFA)-like phenotype,when overexpressed

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0046923ER retention sequence binding IEA--
     
Find genes that share ontologies with KDELR3           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for KDELR3:
 Decreased homologous recombina  Decreased viability 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KDELR3
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KDELR3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KDELR3
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KDELR3

miRNA
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Block miRNA regulation of human, mouse, rat KDELR3 using miScript Target Protectors
7 qRT-PCR Assays for microRNAs that regulate KDELR3:
hsa-miR-548a-3p hsa-miR-875-3p hsa-miR-137 hsa-miR-924 hsa-miR-548e hsa-miR-488 hsa-miR-619
SwitchGear 3'UTR luciferase reporter plasmidKDELR3 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat KDELR3

Gene Editing
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GenScript: all cDNA clones in your preferred vector (see all 2): KDELR3 (NM_006855)
Sino Biological Human cDNA Clone for KDELR3
DNA2.0 Custom Codon Optimized Gene Synthesis Service for KDELR3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDELR3

Cell Line
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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ERD23_HUMAN, O43731: Endoplasmic reticulum membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum5
extracellular2
cytoskeleton1
cytosol1
mitochondrion1
plasma membrane1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005789endoplasmic reticulum membrane TAS--
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with KDELR3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for KDELR3 About   (see all 6)  
See pathways by source

SuperPathContained pathways About
1Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA0.77
Activation of PKA through GPCR0.71
cAMP Pathway0.77
PKA Signaling0.56
2Unfolded Protein Response
Unfolded Protein Response0.61
Activation of Chaperone Genes by XBP1(S)0.59
Activation of Chaperones by IRE1alpha0.61
3G Protein Signaling Pathways
Signal transduction cAMP signaling0.44
4Insulin receptor recycling
Vibrio cholerae infection0.40
5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins0.30


Find genes that share SuperPaths with KDELR3           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KDELR3
    Activation of PKA through GPCR
PKA Signaling
cAMP Pathway
Activation of cAMP-Dependent PKA

2 GeneGo (Thomson Reuters) Pathways for KDELR3
    Signal transduction cAMP signaling
Signal transduction PKA signaling


1 Reactome Pathway for KDELR3
    XBP1(S) activates chaperone genes


1 Kegg Pathway  (Kegg details for KDELR3):
    Vibrio cholerae infection

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KDELR3
Interactions:

    Search GeneGlobe Interaction Network for KDELR3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for KDELR3 (O437313 ENSP000003869184) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
InteractantInteraction Details
GeneCardExternal ID(s)
HIST1H4AP628053I2D: score=1 
HIST1H4BP628053I2D: score=1 
HIST1H4CP628053I2D: score=1 
HIST1H4DP628053I2D: score=1 
HIST1H4EP628053I2D: score=1 
About this table

Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006621protein retention in ER lumen IEA--
GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
GO:0015031protein transport IEA--
GO:0016192vesicle-mediated transport IEA--
GO:0022900electron transport chain ----

Find genes that share ontologies with KDELR3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for KDELR3 (ERD23)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for KDELR3 gene (2 alternative transcripts): 
NM_006855.3  NM_016657.2  

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000216014(uc003avv.3) ENST00000409006(uc003avu.3) ENST00000471268

miRNA
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7 qRT-PCR Assays for microRNAs that regulate KDELR3:
hsa-miR-548a-3p hsa-miR-875-3p hsa-miR-137 hsa-miR-924 hsa-miR-548e hsa-miR-488 hsa-miR-619
SwitchGear 3'UTR luciferase reporter plasmidKDELR3 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for KDELR3
Predesigned siRNA for gene silencing in human, mouse, rat KDELR3
Clone
Products:
     
OriGene clones in human, mouse for KDELR3 (see all 9)
OriGene ORF clones in mouse, rat for KDELR3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): KDELR3 (NM_006855)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for KDELR3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDELR3
Primer
Products:
    
OriGene qPCR primer pairs and template standards for KDELR3
OriGene qSTAR qPCR primer pairs in human, mouse for KDELR3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KDELR3
  QuantiTect SYBR Green Assays in human, mouse, rat KDELR3
  QuantiFast Probe-based Assays in human, mouse, rat KDELR3

Selected AceView cDNA sequences (see all 69):

W21175 CR456509 CR594497 BX095409 CR590826 NM_006855 NM_016657 BM715989 
CR612711 AL035081 BU634108 AL035082 AA505940 CR614427 AI263473 CR594712 
BI763227 CR600149 BC001277 BM749526 BU625076 BI822134 BG249074 CD628116 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KDELR3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATGAGCAAGT
KDELR3 Expression
About this image


KDELR3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 7) fully expand
 
 Limb (Muscoskeletal System)
         Stylopod
 
 Gut Tube (Gastrointestinal Tract)
         Foregut
 
 Peripheral Nervous System (Nervous System)
         Immature Schwann Cells Peripheral Nerve Domain
 
 Bone (Muscoskeletal System)
         Rib
 
 Inner Cell Mass (Early Embryonic Tissues)
         Inner Cell Mass Cells Inner Cell Mass
KDELR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

KDELR3 Protein Expression
    Custom PCR Arrays for KDELR3
Primer
Products:
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QuantiFast Probe-based Assays in human, mouse, rat KDELR3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDELR3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for KDELR3 gene from Selected species (see all 16)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Kdelr31 , 5 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein more1, 5 88.16(n)1
92.52(a)1
  15 (37.76 cM)5
1057851  NM_134090.21  NP_598851.21 
 795164085 
chicken
(Gallus gallus)
Aves KDELR31 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein more 80.84(n)
88.79(a)
  418026  NM_001012996.1  NP_001013014.1 
lizard
(Anolis carolinensis)
Reptilia KDELR36
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum prote...
86(a)
1 ↔ 1
GL343460.1(615231-626740)
African clawed frog
(Xenopus laevis)
Amphibia MGC643132 hypothetical protein MGC64313 74.56(n)    AJ001533.1 
zebrafish
(Danio rerio)
Actinopterygii BC057436.12   -- 77.53(n)   393613  BC057436.1 
fruit fly
(Drosophila melanogaster)
Insecta KdelR3 retrograde (Golgi to ER) transport KDEL
receptor
66(a)   31E1   --
worm
(Caenorhabditis elegans)
Secernentea C28H8.43 ER lumen protein retaining receptor 61(a)   III(5978584-5980088)   --
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERD26
HDEL receptor, an integral membrane protein that b...
46(a)
1 → many
II(142112-142868) YBL040C
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.29122 Vitis vinifera transcribed sequence with moderate similarity more 77.28(n)    CF210886.1 


ENSEMBL Gene Tree for KDELR3 (if available)
TreeFam Gene Tree for KDELR3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for KDELR3 gene
KDELR12  KDELR22  
2 SIMAP similar genes for KDELR3 using alignment to 1 protein entry:     ERD23_HUMAN:
KDELR1    KDELR2

Find genes that share paralogs with KDELR3           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for KDELR3 (see all 406)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1499523521,2
--38862163(+) CCGGCC/TGCTCA 2 -- us2k10--------
rs1450245541,2
C--38862206(+) CCATGA/GCAACC 2 -- us2k10--------
rs1405256421,2
C--38862222(+) TGTAAA/GGGAAT 2 -- us2k10--------
rs1443840361,2
--38862243(+) TAGACC/TGTGTG 2 -- us2k10--------
rs1476945481,2
C--38862319(+) GCCTCA/G/TCTTTC 2 -- us2k10--------
rs1867369021,2
--38862337(+) GTGAAA/GTGAGA 2 -- us2k10--------
rs789913531,2
C,F--38862381(+) ATGAGT/AGCCTT 2 -- us2k11Minor allele frequency- A:0.05WA 118
rs1423905661,2
--38862429(+) GTGTGC/TACATC 2 -- us2k10--------
rs1918786961,2
--38862517(+) TCTTTA/GGACTG 2 -- us2k10--------
rs1384181,2
C,F,A--38862628(+) GAGTTC/TGAGAC 2 -- us2k15Minor allele frequency- T:0.50NA CSA 8

HapMap Linkage Disequilibrium report for KDELR3 (38864067 - 38879452 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for KDELR3:    About this table    
Variant IDTypeSubtypePubMed ID
nsv834195CNV Loss17160897
dgv4970n71CNV Loss21882294
nsv915066CNV Loss21882294
nsv817994CNV Gain17921354

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing KDELR3
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for KDELR3 gene integrated from 10 sources:
(articles sorted by number of sources associating them with KDELR3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
  3. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)1, 2 Collins J.E.... Dunham I. (Genome Res. 2003)
  4. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  7. Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis. (PubMed id 11827452)1 Jia L....Francomano C.A. (Genomics 2002)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  9. The dynamic organisation of the secretory pathway. (PubMed id 9118249)1 Pelham H.R. (Cell Struct. Funct. 1996)
  10. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11015 HGNC: 6306 AceView: KDELR3 Ensembl:ENSG00000100196 euGenes: HUgn11015
ECgene: KDELR3 Kegg: 11015 H-InvDB: KDELR3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for KDELR3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for KDELR3 gene:
Search GeneIP for patents involving KDELR3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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