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Aliases for KDELR3 Gene

Aliases for KDELR3 Gene

  • KDEL Endoplasmic Reticulum Protein Retention Receptor 3 2 3 4 5
  • KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 3 2 3
  • KDEL Receptor 3 3 4
  • ER Lumen Protein-Retaining Receptor 3 3
  • ERD2L3 3

External Ids for KDELR3 Gene

Previous GeneCards Identifiers for KDELR3 Gene

  • GC22P035478
  • GC22P037107
  • GC22P037189
  • GC22P038864
  • GC22P021830

Summaries for KDELR3 Gene

Entrez Gene Summary for KDELR3 Gene

  • This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for KDELR3 Gene

KDELR3 (KDEL Endoplasmic Reticulum Protein Retention Receptor 3) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Transport to the Golgi and subsequent modification. GO annotations related to this gene include ER retention sequence binding. An important paralog of this gene is KDELR2.

UniProtKB/Swiss-Prot for KDELR3 Gene

  • Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity).

Gene Wiki entry for KDELR3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KDELR3 Gene

Genomics for KDELR3 Gene

Regulatory Elements for KDELR3 Gene

Enhancers for KDELR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F038422 0.7 Ensembl ENCODE 17.7 -44.2 -44200 3.0 KLF17 FEZF1 RARA ZNF366 SCRT2 ETV6 EGR2 ZNF263 SP3 USF2 CSNK1E KDELR3 ENSG00000244627 LOC400927-CSNK1E KCNJ4 TAB1 CBY1 SOX10 POLR2F ENSG00000230912
GH22F038655 1 ENCODE 12.9 +188.7 188651 2.4 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A BRCA1 ZNF121 SLC30A9 GLIS2 ZNF263 CBY1 ENSG00000228274 KDELR3 JOSD1 ENSG00000230912
GH22F038256 0.6 Ensembl ENCODE 12.9 -208.4 -208397 6.8 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YY1 CBX5 ZNF143 ZNF263 SP3 KDELR3 TMEM184B PLA2G6 CBY1 PICK1 ANKRD54 RN7SL704P
GH22F038681 0.2 ENCODE 12.9 +214.0 214040 1.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 CBY1 SNORD83B SNORD83A KDELR3 ENSG00000230149 ENSG00000273076 PRDX3P1 ENSG00000230912 CSNK1E ENSG00000228274
GH22F037847 0.4 ENCODE 12.9 -618.9 -618924 2.6 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 KLF13 EIF3L KDELR3 CBY1 GCAT H1F0 ENSG00000230149 ENSG00000273076 BAIAP2L2 GC22M041367 PIR48437
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KDELR3 on UCSC Golden Path with GeneCards custom track

Promoters for KDELR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000170374 338 1601 ATF1 CREB3L1 KLF17 DMAP1 ZNF48 ZBTB40 ZNF2 GLIS2 EGR1 SCRT2

Genomic Location for KDELR3 Gene

Chromosome:
22
Start:
38,468,062 bp from pter
End:
38,483,447 bp from pter
Size:
15,386 bases
Orientation:
Plus strand

Genomic View for KDELR3 Gene

Genes around KDELR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KDELR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KDELR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KDELR3 Gene

Proteins for KDELR3 Gene

  • Protein details for KDELR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43731-ERD23_HUMAN
    Recommended name:
    ER lumen protein-retaining receptor 3
    Protein Accession:
    O43731
    Secondary Accessions:
    • A8K7T7
    • B8ZZ26
    • O95557
    • Q4V750
    • Q4V767
    • Q53FP4
    • Q53GK1

    Protein attributes for KDELR3 Gene

    Size:
    214 amino acids
    Molecular mass:
    25027 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KDELR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KDELR3 Gene

Post-translational modifications for KDELR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KDELR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KDELR3 Gene

Domains & Families for KDELR3 Gene

Protein Domains for KDELR3 Gene

Suggested Antigen Peptide Sequences for KDELR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43731

UniProtKB/Swiss-Prot:

ERD23_HUMAN :
  • Belongs to the ERD2 family.
Family:
  • Belongs to the ERD2 family.
genes like me logo Genes that share domains with KDELR3: view

No data available for Gene Families for KDELR3 Gene

Function for KDELR3 Gene

Molecular function for KDELR3 Gene

GENATLAS Biochemistry:
endoplasmic reticulum protein retention receptor 3 (Lys-Asp-Glu-Leu),S cerevisiae ERD2 ortholog,allowing the retrieval of proteins from Golgi complex to ER,mimicking the brefeldin A (BFA)-like phenotype,when overexpressed
UniProtKB/Swiss-Prot Function:
Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity).

Gene Ontology (GO) - Molecular Function for KDELR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046923 ER retention sequence binding IEA --
genes like me logo Genes that share ontologies with KDELR3: view
genes like me logo Genes that share phenotypes with KDELR3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KDELR3 Gene

Localization for KDELR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDELR3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KDELR3 Gene COMPARTMENTS Subcellular localization image for KDELR3 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
cytoskeleton 1
cytosol 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KDELR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KDELR3: view

Pathways & Interactions for KDELR3 Gene

genes like me logo Genes that share pathways with KDELR3: view

Gene Ontology (GO) - Biological Process for KDELR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006621 protein retention in ER lumen IEA --
GO:0006810 transport IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with KDELR3: view

No data available for SIGNOR curated interactions for KDELR3 Gene

Transcripts for KDELR3 Gene

mRNA/cDNA for KDELR3 Gene

Unigene Clusters for KDELR3 Gene

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KDELR3 Gene

No ASD Table

Relevant External Links for KDELR3 Gene

GeneLoc Exon Structure for
KDELR3
ECgene alternative splicing isoforms for
KDELR3

Expression for KDELR3 Gene

mRNA expression in normal human tissues for KDELR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KDELR3 Gene

This gene is overexpressed in Oral epithelium (29.3) and Bone (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KDELR3 Gene



Protein tissue co-expression partners for KDELR3 Gene

NURSA nuclear receptor signaling pathways regulating expression of KDELR3 Gene:

KDELR3

SOURCE GeneReport for Unigene cluster for KDELR3 Gene:

Hs.745072
genes like me logo Genes that share expression patterns with KDELR3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KDELR3 Gene

Orthologs for KDELR3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KDELR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KDELR3 34 35
  • 99.38 (n)
cow
(Bos Taurus)
Mammalia KDELR3 34 35
  • 93.93 (n)
dog
(Canis familiaris)
Mammalia KDELR3 34 35
  • 93.61 (n)
rat
(Rattus norvegicus)
Mammalia Kdelr3 34
  • 88.63 (n)
mouse
(Mus musculus)
Mammalia Kdelr3 34 16 35
  • 88.16 (n)
oppossum
(Monodelphis domestica)
Mammalia KDELR3 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves KDELR3 34 35
  • 80.84 (n)
lizard
(Anolis carolinensis)
Reptilia KDELR3 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kdelr3 34
  • 74.77 (n)
Str.8306 34
African clawed frog
(Xenopus laevis)
Amphibia MGC64313 34
zebrafish
(Danio rerio)
Actinopterygii KDELR3 (2 of 2) 35
  • 74 (a)
OneToMany
kdelr3 34 35
  • 72.12 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta KdelR 36 35
  • 66 (a)
worm
(Caenorhabditis elegans)
Secernentea C28H8.4 36 35
  • 61 (a)
erd-2 35
  • 57 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERD2 35
  • 46 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2912 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 71 (a)
ManyToMany
-- 35
  • 71 (a)
ManyToMany
Species where no ortholog for KDELR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KDELR3 Gene

ENSEMBL:
Gene Tree for KDELR3 (if available)
TreeFam:
Gene Tree for KDELR3 (if available)

Paralogs for KDELR3 Gene

Paralogs for KDELR3 Gene

(2) SIMAP similar genes for KDELR3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KDELR3: view

Variants for KDELR3 Gene

Sequence variations from dbSNP and Humsavar for KDELR3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1043402 -- 38,483,683(+) ACAAC(A/G)AATTG downstream-variant-500B, utr-variant-3-prime
rs111255307 -- 38,474,161(+) CTCTG(C/G)GGGTG intron-variant
rs111504481 -- 38,482,390(+) ACATA(C/T)ACTGT intron-variant
rs111658957 -- 38,480,395(+) CACCT(C/T)GGCCT intron-variant
rs111666272 -- 38,471,483(+) CGTGC(C/G)CGCGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KDELR3 Gene

Variant ID Type Subtype PubMed ID
esv3558159 CNV deletion 23714750
esv3647732 CNV gain 21293372
esv3647733 CNV loss 21293372
nsv817994 CNV gain 17921354
nsv834195 CNV loss 17160897

Variation tolerance for KDELR3 Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.38; 88.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KDELR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KDELR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KDELR3 Gene

Disorders for KDELR3 Gene

Relevant External Links for KDELR3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KDELR3

No disorders were found for KDELR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KDELR3 Gene

Publications for KDELR3 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PMID: 12529303) Collins J.E. … Dunham I. (Genome Res. 2003) 3 4 64
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 64
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64

Products for KDELR3 Gene

Sources for KDELR3 Gene

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