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Aliases for KDELC2 Gene

Aliases for KDELC2 Gene

  • KDEL Motif Containing 2 2 3 5
  • KDEL (Lys-Asp-Glu-Leu) Containing 2 2

External Ids for KDELC2 Gene

Previous GeneCards Identifiers for KDELC2 Gene

  • GC11M107848
  • GC11M108342
  • GC11M104268

Summaries for KDELC2 Gene

GeneCards Summary for KDELC2 Gene

KDELC2 (KDEL Motif Containing 2) is a Protein Coding gene. An important paralog of this gene is KDELC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KDELC2 Gene

Genomics for KDELC2 Gene

Regulatory Elements for KDELC2 Gene

Enhancers for KDELC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F108559 1.1 Ensembl ENCODE 34.2 -62.8 -62838 4.2 PKNOX1 TEAD4 FEZF1 ZIC2 ZNF2 ZFHX2 ZNF766 ZNF366 ZEB2 TSHZ1 KDELC2 EXPH5 ATM GC11M108506
GH11F108551 0.8 Ensembl ENCODE 31.3 -53.5 -53488 2.0 TBP HDAC1 PKNOX1 ATF1 TBL1XR1 ZBTB40 YY1 GATA2 SCRT2 CREM KDELC2 DDX10 EXPH5 GC11M108506
GH11F108496 1.1 ENCODE 26.8 +0.7 660 3.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 KDELC2 DDX10 ACAT1 LOC105369479
GH11F108432 0.2 ENCODE 18.2 +65.5 65516 1.8 MTA2 KDELC2 ACAT1 C11orf65 PIR35860
GH11F108518 0.2 ENCODE 17.8 -20.4 -20410 1.4 KDELC2 GC11M108506 EXPH5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KDELC2 on UCSC Golden Path with GeneCards custom track

Promoters for KDELC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001573243 319 2001 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for KDELC2 Gene

Chromosome:
11
Start:
108,472,105 bp from pter
End:
108,498,519 bp from pter
Size:
26,415 bases
Orientation:
Minus strand

Genomic View for KDELC2 Gene

Genes around KDELC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KDELC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KDELC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KDELC2 Gene

Proteins for KDELC2 Gene

  • Protein details for KDELC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4H8-KDEL2_HUMAN
    Recommended name:
    KDEL motif-containing protein 2
    Protein Accession:
    Q7Z4H8
    Secondary Accessions:
    • Q6UWW2
    • Q6ZUM9
    • Q8N7L8
    • Q8NE24

    Protein attributes for KDELC2 Gene

    Size:
    507 amino acids
    Molecular mass:
    58572 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05260.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KDELC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KDELC2 Gene

Post-translational modifications for KDELC2 Gene

  • Glycosylation at Asn 61, Thr 158, and Asn 306
  • Modification sites at PhosphoSitePlus

Other Protein References for KDELC2 Gene

No data available for DME Specific Peptides for KDELC2 Gene

Domains & Families for KDELC2 Gene

Gene Families for KDELC2 Gene

Suggested Antigen Peptide Sequences for KDELC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z4H8

UniProtKB/Swiss-Prot:

KDEL2_HUMAN :
  • Belongs to the KDELC family.
  • Contains 1 filamin repeat.
Family:
  • Belongs to the KDELC family.
Similarity:
  • Contains 1 filamin repeat.
genes like me logo Genes that share domains with KDELC2: view

Function for KDELC2 Gene

Gene Ontology (GO) - Molecular Function for KDELC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0046527 glucosyltransferase activity IBA --
genes like me logo Genes that share ontologies with KDELC2: view
genes like me logo Genes that share phenotypes with KDELC2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KDELC2 Gene

Localization for KDELC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDELC2 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KDELC2 Gene COMPARTMENTS Subcellular localization image for KDELC2 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 2
nucleus 2
cytosol 1
extracellular 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KDELC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen IEA,IBA --
genes like me logo Genes that share ontologies with KDELC2: view

Pathways & Interactions for KDELC2 Gene

SuperPathways for KDELC2 Gene

No Data Available

Interacting Proteins for KDELC2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000315386%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000315386 Q7Z4H8-KDEL2_HUMAN for KDELC2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for KDELC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006664 glycolipid metabolic process IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KDELC2: view

No data available for Pathways by source and SIGNOR curated interactions for KDELC2 Gene

Transcripts for KDELC2 Gene

Unigene Clusters for KDELC2 Gene

KDEL (Lys-Asp-Glu-Leu) containing 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KDELC2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1:
SP2:
SP3: - -
SP4: - -
SP5:
SP6: -

Relevant External Links for KDELC2 Gene

GeneLoc Exon Structure for
KDELC2
ECgene alternative splicing isoforms for
KDELC2

Expression for KDELC2 Gene

mRNA expression in normal human tissues for KDELC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KDELC2 Gene

This gene is overexpressed in Uterus (11.8), Placenta (9.6), and Ovary (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KDELC2 Gene



Protein tissue co-expression partners for KDELC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KDELC2 Gene:

KDELC2

SOURCE GeneReport for Unigene cluster for KDELC2 Gene:

Hs.83286
genes like me logo Genes that share expression patterns with KDELC2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KDELC2 Gene

Orthologs for KDELC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KDELC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KDELC2 34 35
  • 99.54 (n)
cow
(Bos Taurus)
Mammalia KDELC2 34 35
  • 90.01 (n)
dog
(Canis familiaris)
Mammalia KDELC2 34 35
  • 89.28 (n)
mouse
(Mus musculus)
Mammalia Kdelc2 34 16 35
  • 85.86 (n)
rat
(Rattus norvegicus)
Mammalia Kdelc2 34
  • 85.17 (n)
chicken
(Gallus gallus)
Aves KDELC2 34 35
  • 76.55 (n)
lizard
(Anolis carolinensis)
Reptilia KDELC2 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kdelc2 34
  • 72.6 (n)
Str.926 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25802 34
zebrafish
(Danio rerio)
Actinopterygii kdelc2 34 35
  • 64.64 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6610 34
fruit fly
(Drosophila melanogaster)
Insecta CG31139 35
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToMany
Species where no ortholog for KDELC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KDELC2 Gene

ENSEMBL:
Gene Tree for KDELC2 (if available)
TreeFam:
Gene Tree for KDELC2 (if available)

Paralogs for KDELC2 Gene

Paralogs for KDELC2 Gene

(1) SIMAP similar genes for KDELC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KDELC2: view

Variants for KDELC2 Gene

Sequence variations from dbSNP and Humsavar for KDELC2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10431062 -- 108,499,390(+) CACAC(A/C)TCCCT nc-transcript-variant, upstream-variant-2KB
rs1051141 -- 108,472,344(-) TATAC(C/T)TTTCT utr-variant-3-prime
rs10556296 -- 108,493,731(+) CCCAG(-/GA)GGCGG intron-variant
rs10715963 -- 108,481,727(+) AAAGC(-/A)AAAAA intron-variant
rs10749918 -- 108,484,147(+) CAACC(C/G)CTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KDELC2 Gene

Variant ID Type Subtype PubMed ID
esv3627677 CNV loss 21293372
nsv832263 CNV gain 17160897

Variation tolerance for KDELC2 Gene

Residual Variation Intolerance Score: 57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.29; 53.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KDELC2 Gene

Human Gene Mutation Database (HGMD)
KDELC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KDELC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KDELC2 Gene

Disorders for KDELC2 Gene

Relevant External Links for KDELC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KDELC2

No disorders were found for KDELC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KDELC2 Gene

Publications for KDELC2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64

Products for KDELC2 Gene

Sources for KDELC2 Gene

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