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Aliases for KDELC2 Gene

Aliases for KDELC2 Gene

  • KDEL (Lys-Asp-Glu-Leu) Containing 2 2 3

External Ids for KDELC2 Gene

Summaries for KDELC2 Gene

GeneCards Summary for KDELC2 Gene

KDELC2 (KDEL (Lys-Asp-Glu-Leu) Containing 2) is a Protein Coding gene. An important paralog of this gene is KDELC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KDELC2 Gene

Genomics for KDELC2 Gene

Genomic Location for KDELC2 Gene

Start:
108,472,105 bp from pter
End:
108,498,432 bp from pter
Size:
26,328 bases
Orientation:
Minus strand

Genomic View for KDELC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KDELC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KDELC2 Gene

Regulatory Elements for KDELC2 Gene

Proteins for KDELC2 Gene

  • Protein details for KDELC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4H8-KDEL2_HUMAN
    Recommended name:
    KDEL motif-containing protein 2
    Protein Accession:
    Q7Z4H8
    Secondary Accessions:
    • Q6UWW2
    • Q6ZUM9
    • Q8N7L8
    • Q8NE24

    Protein attributes for KDELC2 Gene

    Size:
    507 amino acids
    Molecular mass:
    58572 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05260.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KDELC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KDELC2 Gene

Proteomics data for KDELC2 Gene at MOPED

Post-translational modifications for KDELC2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn61, Thr158, and Asn306

Other Protein References for KDELC2 Gene

No data available for DME Specific Peptides for KDELC2 Gene

Domains for KDELC2 Gene

Protein Domains for KDELC2 Gene

UniProtKB/Swiss-Prot:

KDEL2_HUMAN
Family:
  • Belongs to the KDELC family.:
    • Q7Z4H8
Similarity:
  • Contains 1 filamin repeat.:
    • Q7Z4H8
genes like me logo Genes that share domains with KDELC2: view

No data available for Gene Families for KDELC2 Gene

Function for KDELC2 Gene

Gene Ontology (GO) - Molecular Function for KDELC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KDELC2: view

Phenotypes for KDELC2 Gene

genes like me logo Genes that share phenotypes with KDELC2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KDELC2 Gene

Localization for KDELC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDELC2 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KDELC2 Gene COMPARTMENTS Subcellular localization image for KDELC2 gene
Compartment Confidence
endoplasmic reticulum 3
mitochondrion 2
cytosol 1
extracellular 1
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KDELC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005783 endoplasmic reticulum --
GO:0005788 endoplasmic reticulum lumen IEA --
genes like me logo Genes that share ontologies with KDELC2: view

Pathways for KDELC2 Gene

SuperPathways for KDELC2 Gene

No Data Available

Interacting Proteins for KDELC2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000315386%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000315386 for KDELC2 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for KDELC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KDELC2: view

No data available for Pathways by source for KDELC2 Gene

Transcripts for KDELC2 Gene

Unigene Clusters for KDELC2 Gene

KDEL (Lys-Asp-Glu-Leu) containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KDELC2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1:
SP2:
SP3: - -
SP4: - -
SP5:
SP6: -

Relevant External Links for KDELC2 Gene

GeneLoc Exon Structure for
KDELC2
ECgene alternative splicing isoforms for
KDELC2

Expression for KDELC2 Gene

mRNA expression in normal human tissues for KDELC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KDELC2 Gene

SOURCE GeneReport for Unigene cluster for KDELC2 Gene Hs.83286

genes like me logo Genes that share expressions with KDELC2: view

Orthologs for KDELC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KDELC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KDELC2 36
  • 99.54 (n)
  • 99.8 (a)
KDELC2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KDELC2 36
  • 90.01 (n)
  • 90.93 (a)
KDELC2 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KDELC2 36
  • 89.28 (n)
  • 89.15 (a)
KDELC2 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kdelc2 36
  • 85.86 (n)
  • 87.32 (a)
Kdelc2 16
Kdelc2 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kdelc2 36
  • 85.17 (n)
  • 88.15 (a)
chicken
(Gallus gallus)
Aves KDELC2 36
  • 76.55 (n)
  • 78.32 (a)
KDELC2 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KDELC2 37
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25802 36
tropical clawed frog
(Silurana tropicalis)
Amphibia kdelc2 36
  • 72.6 (n)
  • 75.57 (a)
Str.926 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6610 36
zebrafish
(Danio rerio)
Actinopterygii kdelc2 36
  • 64.64 (n)
  • 69.87 (a)
kdelc2 37
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31139 37
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 48 (a)
OneToMany
Species with no ortholog for KDELC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KDELC2 Gene

ENSEMBL:
Gene Tree for KDELC2 (if available)
TreeFam:
Gene Tree for KDELC2 (if available)

Paralogs for KDELC2 Gene

Paralogs for KDELC2 Gene

Selected SIMAP similar genes for KDELC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KDELC2: view

Variants for KDELC2 Gene

Sequence variations from dbSNP and Humsavar for KDELC2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs11686 -- 108,472,373(-) GGAGT(A/G)AAGGG utr-variant-3-prime
rs751343 -- 108,495,722(+) GGCAC(A/C)ATCAT intron-variant
rs893279 -- 108,494,455(-) TGATT(A/G)TCGTA intron-variant
rs1051141 -- 108,472,344(-) TATAC(C/T)TTTCT utr-variant-3-prime
rs2118309 -- 108,496,726(-) CTTGT(G/T)TTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KDELC2 Gene

Variant ID Type Subtype PubMed ID
nsv832263 CNV Gain 17160897

Relevant External Links for KDELC2 Gene

HapMap Linkage Disequilibrium report
KDELC2
Human Gene Mutation Database (HGMD)
KDELC2

Disorders for KDELC2 Gene

No disorders were found for KDELC2 Gene.

No data available for UniProtKB/Swiss-Prot for KDELC2 Gene

Publications for KDELC2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3

Products for KDELC2 Gene

Sources for KDELC2 Gene

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