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Aliases for KDELC1 Gene

Aliases for KDELC1 Gene

  • KDEL Motif Containing 1 2 3 5
  • Endoplasmic Reticulum Resident Protein 58 3 4
  • KDEL (Lys-Asp-Glu-Leu) Containing 1 2 3
  • ER Protein 58 3 4
  • ERp58 3 4
  • EP58 3 4
  • KDEL Motif-Containing 1 3
  • KDEL1 3

External Ids for KDELC1 Gene

Previous GeneCards Identifiers for KDELC1 Gene

  • GC13M101796
  • GC13M097823
  • GC13M102273
  • GC13M101134
  • GC13M102234
  • GC13M103436
  • GC13M084028

Summaries for KDELC1 Gene

Entrez Gene Summary for KDELC1 Gene

  • This gene encodes a protein product localized to the lumen of the endoplasmic reticulum. As a member of the endoplasmic reticulum protein family the encoded protein contains a Lys-Asp-Glu-Leu or KDEL motif located at the extreme C-terminus which prevents all endoplasmic reticulum resident proteins from being secreted. Proteins carrying this motif are bound by a receptor in the Golgi apparatus so that the receptor-ligand complex returns to the endoplasmic reticulum. A processed non-transcribed pseudogene located in an intron of a sodium transporter gene on chromosome 5 has been defined for this gene. This gene has multiple transcript variants which are predicted to encode distinct isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for KDELC1 Gene

KDELC1 (KDEL Motif Containing 1) is a Protein Coding gene. An important paralog of this gene is POGLUT1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KDELC1 Gene

Genomics for KDELC1 Gene

Regulatory Elements for KDELC1 Gene

Enhancers for KDELC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KDELC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for KDELC1 Gene

102,784,281 bp from pter
102,799,054 bp from pter
14,774 bases
Minus strand

Genomic View for KDELC1 Gene

Genes around KDELC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KDELC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KDELC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KDELC1 Gene

Proteins for KDELC1 Gene

  • Protein details for KDELC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    KDEL motif-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q53HL3
    • Q9BVD2

    Protein attributes for KDELC1 Gene

    502 amino acids
    Molecular mass:
    58043 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KDELC1 Gene

neXtProt entry for KDELC1 Gene

Proteomics data for KDELC1 Gene at MOPED

Post-translational modifications for KDELC1 Gene

Other Protein References for KDELC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KDELC1 Gene

Domains & Families for KDELC1 Gene

Gene Families for KDELC1 Gene

Protein Domains for KDELC1 Gene

Suggested Antigen Peptide Sequences for KDELC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the KDELC family.
  • Contains 1 filamin repeat.
  • Belongs to the KDELC family.
  • Contains 1 filamin repeat.
genes like me logo Genes that share domains with KDELC1: view

Function for KDELC1 Gene

genes like me logo Genes that share phenotypes with KDELC1: view

Animal Model Products

CRISPR Products

miRNA for KDELC1 Gene

miRTarBase miRNAs that target KDELC1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KDELC1 Gene

Localization for KDELC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDELC1 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

Jensen Localization Image for KDELC1 Gene COMPARTMENTS Subcellular localization image for KDELC1 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 3
cytosol 2
extracellular 1
lysosome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for KDELC1 Gene

Pathways & Interactions for KDELC1 Gene

SuperPathways for KDELC1 Gene

No Data Available

Interacting Proteins for KDELC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000365172 for KDELC1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for KDELC1 Gene


No data available for Pathways by source and SIGNOR curated interactions for KDELC1 Gene

Drugs & Compounds for KDELC1 Gene

No Compound Related Data Available

Transcripts for KDELC1 Gene

Unigene Clusters for KDELC1 Gene

KDEL (Lys-Asp-Glu-Leu) containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KDELC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP2: -

Relevant External Links for KDELC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KDELC1 Gene

mRNA expression in normal human tissues for KDELC1 Gene

Protein differential expression in normal tissues from HIPED for KDELC1 Gene

This gene is overexpressed in Serum (51.7) and Liver (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for KDELC1 Gene

SOURCE GeneReport for Unigene cluster for KDELC1 Gene Hs.408629

genes like me logo Genes that share expression patterns with KDELC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KDELC1 Gene

Orthologs for KDELC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KDELC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KDELC1 35
  • 89.31 (n)
  • 93.43 (a)
  • 93 (a)
(Canis familiaris)
Mammalia KDELC1 35
  • 91.24 (n)
  • 95.42 (a)
  • 95 (a)
(Mus musculus)
Mammalia Kdelc1 35
  • 87.85 (n)
  • 92.03 (a)
Kdelc1 16
Kdelc1 36
  • 92 (a)
(Pan troglodytes)
Mammalia KDELC1 35
  • 99.2 (n)
  • 99.2 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Kdelc1 35
  • 87.25 (n)
  • 91.63 (a)
(Monodelphis domestica)
Mammalia KDELC1 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia KDELC1 36
  • 84 (a)
(Gallus gallus)
Aves KDELC1 35
  • 76.97 (n)
  • 82.13 (a)
  • 80 (a)
(Anolis carolinensis)
Reptilia KDELC1 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kdelc1 35
  • 71.65 (n)
  • 74.18 (a)
(Danio rerio)
Actinopterygii kdelc1 35
  • 67.41 (n)
  • 67.55 (a)
zgc56065 35
kdelc1 36
  • 66 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008037 35
  • 51.91 (n)
  • 46.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31139 36
  • 25 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8607 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
Species with no ortholog for KDELC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KDELC1 Gene

Gene Tree for KDELC1 (if available)
Gene Tree for KDELC1 (if available)

Paralogs for KDELC1 Gene

Paralogs for KDELC1 Gene

(2) SIMAP similar genes for KDELC1 Gene using alignment to 2 proteins: Pseudogenes for KDELC1 Gene

genes like me logo Genes that share paralogs with KDELC1: view

Variants for KDELC1 Gene

Sequence variations from dbSNP and Humsavar for KDELC1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1047740 - 102,796,852(-) TGGAA(A/G)TTAAA reference, missense, utr-variant-5-prime
rs1047759 -- 102,784,406(-) CATGG(A/G)CAATA downstream-variant-500B, utr-variant-3-prime
rs2274387 -- 102,790,792(+) TTGTG(A/C)TAACT intron-variant
rs2296649 -- 102,788,859(+) GGGAA(C/G)TGCCG intron-variant
rs3818480 -- 102,788,838(+) TGCCC(A/G)CTGTG intron-variant

Variation tolerance for KDELC1 Gene

Residual Variation Intolerance Score: 24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.71; 94.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for KDELC1 Gene

Disorders for KDELC1 Gene

Relevant External Links for KDELC1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KDELC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KDELC1 Gene

Publications for KDELC1 Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3

Products for KDELC1 Gene

Sources for KDELC1 Gene