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Aliases for KDELC1 Gene

Aliases for KDELC1 Gene

  • KDEL (Lys-Asp-Glu-Leu) Containing 1 2 3
  • EP58 3 4 6
  • Endoplasmic Reticulum Resident Protein 58 3 4
  • ER Protein 58 3 4
  • ERp58 3 4
  • KDEL Motif-Containing Protein 1 3
  • KDEL Motif-Containing 1 3
  • KDEL1 3

External Ids for KDELC1 Gene

Summaries for KDELC1 Gene

Entrez Gene Summary for KDELC1 Gene

  • This gene encodes a protein product localized to the lumen of the endoplasmic reticulum. As a member of the endoplasmic reticulum protein family the encoded protein contains a Lys-Asp-Glu-Leu or KDEL motif located at the extreme C-terminus which prevents all endoplasmic reticulum resident proteins from being secreted. Proteins carrying this motif are bound by a receptor in the Golgi apparatus so that the receptor-ligand complex returns to the endoplasmic reticulum. A processed non-transcribed pseudogene located in an intron of a sodium transporter gene on chromosome 5 has been defined for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for KDELC1 Gene

KDELC1 (KDEL (Lys-Asp-Glu-Leu) Containing 1) is a Protein Coding gene. An important paralog of this gene is POGLUT1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KDELC1 Gene

Genomics for KDELC1 Gene

Genomic Location for KDELC1 Gene

Start:
102,784,281 bp from pter
End:
102,799,054 bp from pter
Size:
14,774 bases
Orientation:
Minus strand

Genomic View for KDELC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KDELC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KDELC1 Gene

Regulatory Elements for KDELC1 Gene

Proteins for KDELC1 Gene

  • Protein details for KDELC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UW63-KDEL1_HUMAN
    Recommended name:
    KDEL motif-containing protein 1
    Protein Accession:
    Q6UW63
    Secondary Accessions:
    • Q53HL3
    • Q9BVD2

    Protein attributes for KDELC1 Gene

    Size:
    502 amino acids
    Molecular mass:
    58043 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KDELC1 Gene

neXtProt entry for KDELC1 Gene

Proteomics data for KDELC1 Gene at MOPED

Post-translational modifications for KDELC1 Gene

Other Protein References for KDELC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KDELC1 Gene

Domains for KDELC1 Gene

Protein Domains for KDELC1 Gene

UniProtKB/Swiss-Prot:

KDEL1_HUMAN
Family:
  • Belongs to the KDELC family.:
    • Q6UW63
Similarity:
  • Contains 1 filamin repeat.:
    • Q6UW63
genes like me logo Genes that share domains with KDELC1: view

No data available for Gene Families for KDELC1 Gene

Function for KDELC1 Gene

Gene Ontology (GO) - Molecular Function for KDELC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KDELC1: view

Phenotypes for KDELC1 Gene

genes like me logo Genes that share phenotypes with KDELC1: view

miRNA for KDELC1 Gene

miRTarBase miRNAs that target KDELC1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KDELC1 Gene

Localization for KDELC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDELC1 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KDELC1 Gene COMPARTMENTS Subcellular localization image for KDELC1 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KDELC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen ISS --
genes like me logo Genes that share ontologies with KDELC1: view

Pathways for KDELC1 Gene

SuperPathways for KDELC1 Gene

No Data Available

Interacting Proteins for KDELC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000365172%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000365172 for KDELC1 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for KDELC1 Gene

None

No data available for Pathways by source for KDELC1 Gene

Transcripts for KDELC1 Gene

Unigene Clusters for KDELC1 Gene

KDEL (Lys-Asp-Glu-Leu) containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KDELC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -

Relevant External Links for KDELC1 Gene

GeneLoc Exon Structure for
KDELC1
ECgene alternative splicing isoforms for
KDELC1

Expression for KDELC1 Gene

mRNA expression in normal human tissues for KDELC1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KDELC1 Gene

SOURCE GeneReport for Unigene cluster for KDELC1 Gene Hs.408629

genes like me logo Genes that share expressions with KDELC1: view

Orthologs for KDELC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KDELC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KDELC1 36
  • 99.2 (n)
  • 99.2 (a)
KDELC1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KDELC1 36
  • 89.31 (n)
  • 93.43 (a)
KDELC1 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KDELC1 36
  • 91.24 (n)
  • 95.42 (a)
KDELC1 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kdelc1 36
  • 87.85 (n)
  • 92.03 (a)
Kdelc1 16
Kdelc1 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KDELC1 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KDELC1 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kdelc1 36
  • 87.25 (n)
  • 91.63 (a)
chicken
(Gallus gallus)
Aves KDELC1 36
  • 76.97 (n)
  • 82.13 (a)
KDELC1 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KDELC1 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kdelc1 36
  • 71.65 (n)
  • 74.18 (a)
zebrafish
(Danio rerio)
Actinopterygii kdelc1 36
  • 67.41 (n)
  • 67.55 (a)
kdelc1 37
  • 66 (a)
OneToOne
zgc56065 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008037 36
  • 51.91 (n)
  • 46.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31139 37
  • 25 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8607 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 51 (a)
OneToMany
Species with no ortholog for KDELC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KDELC1 Gene

ENSEMBL:
Gene Tree for KDELC1 (if available)
TreeFam:
Gene Tree for KDELC1 (if available)

Paralogs for KDELC1 Gene

Paralogs for KDELC1 Gene

Selected SIMAP similar genes for KDELC1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for KDELC1 Gene

genes like me logo Genes that share paralogs with KDELC1: view

Variants for KDELC1 Gene

Sequence variations from dbSNP and Humsavar for KDELC1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1047740 - 102,796,852(-) TGGAA(A/G)TTAAA reference, missense, utr-variant-5-prime
rs1047759 -- 102,784,406(-) CATGG(A/G)CAATA utr-variant-3-prime
rs2274387 -- 102,790,792(+) TTGTG(A/C)TAACT intron-variant
rs2296649 -- 102,788,859(+) GGGAA(C/G)TGCCG intron-variant
rs3818480 -- 102,788,838(+) TGCCC(A/G)CTGTG intron-variant

Relevant External Links for KDELC1 Gene

HapMap Linkage Disequilibrium report
KDELC1

No data available for Structural Variations from Database of Genomic Variants (DGV) for KDELC1 Gene

Disorders for KDELC1 Gene

Relevant External Links for KDELC1

Genetic Association Database (GAD)
KDELC1
genes like me logo Genes that share disorders with KDELC1: view

No data available for UniProtKB/Swiss-Prot for KDELC1 Gene

Publications for KDELC1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Linkage disequilibrium analysis in the LOC93081-KDELC1-BIVM region on 13q in bipolar disorder. (PMID: 15635705) Ferraren D.O. … Detera-Wadleigh S.D. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for KDELC1 Gene

Sources for KDELC1 Gene

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