KDELC1 Gene
protein-coding GIFtS: 44
GCID: GC13M103436
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KDEL (Lys-Asp-Glu-Leu) containing 1
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Aliases
for KDELC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| KDEL (Lys-Asp-Glu-Leu) Containing 11 2 | | MGC53021 | | EP581 2 3 5 | | KDEL12 | | Endoplasmic Reticulum Resident Protein 582 3 | | KDEL Motif-Containing 12 | | ERp582 3 | | KDEL Motif-Containing Protein 12 | | ER Protein 582 3 | | |
Export aliases for KDELC1 gene to outside databasesPrevious GC identifers: GC13M101796 GC13M097823 GC13M102273 GC13M101134 GC13M102234 GC13M084028 |
Summaries
for KDELC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KDELC1:
This gene encodes a protein product localized to the lumen of the endoplasmic reticulum. As a member of the endoplasmicreticulum protein family the encoded protein contains a Lys-Asp-Glu-Leu or KDEL motif located at the extremeC-terminus which prevents all endoplasmic reticulum resident proteins from being secreted. Proteins carrying thismotif are bound by a receptor in the Golgi apparatus so that the receptor-ligand complex returns to the endoplasmicreticulum. A processed non-transcribed pseudogene located in an intron of a sodium transporter gene on chromosome 5has been defined for this gene. (provided by RefSeq, Jul 2008)
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Genomic Views
for KDELC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_009952.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KDELC1 gene promoter:
Oct-B1 Elk-1 oct-B3 oct-B2 Brachyury YY1 HNF-1A POU2F1 POU2F1a HNF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KDELC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDELC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q33 Ensembl cytogenetic band: 13q33.1 HGNC cytogenetic band: 13q33KDELC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M103436: view genomic region
(about GC identifiers)
Start:
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103,436,631 bp from pter |
End:
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103,451,404 bp from pter |
Size:
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14,774 bases |
Orientation:
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minus strand |
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Proteins
for KDELC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KDEL1_HUMAN, Q6UW63 (See
protein sequence)Recommended Name: KDEL motif-containing protein 1 precursor Size: 502 amino acids; 58043 Da
Subcellular location: Endoplasmic reticulum lumen (By similarity)
1 PDB 3D structure from  and Proteopedia  for KDELC1:2DI7 (3D)
Secondary accessions: Q53HL3 Q9BVD2Explore the universe of human proteins at neXtProt for KDELC1: NX_Q6UW63
Post-translational modifications:
N-glycosylated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UW63
KDELC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_076994.2
ENSEMBL proteins: ENSP00000365172
Human Recombinant Protein Products for KDELC1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005788 | endoplasmic reticulum lumen |
ISS | -- |
KDELC1 for ontologies About GeneDecksing
KDELC1 Antibody Products:
Assay Products for KDELC1: |
Protein
Domains /
Families
for KDELC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KDELC1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6UW63ProtoNet protein and cluster: Q6UW63 UniProtKB/Swiss-Prot: KDEL1_HUMAN, Q6UW63Similarity: Belongs to the KDELC familySimilarity: Contains 1 filamin repeat |
Function
for KDELC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
2 GenomeRNAi human phenotypes for KDELC1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KDELC1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KDELC1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KDELC1 (NM_024089) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KDELC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDELC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDELC1 |
|
Pathways & Interactions
for KDELC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KDELC1
|
Drugs & Compounds
for KDELC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KDELC1
Search CenterWatch for drugs/clinical trials and news about KDELC1 / KDEL1
|
Transcripts
for KDELC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KDELC1 gene: NM_024089.2 Unigene Cluster for KDELC1: KDEL (Lys-Asp-Glu-Leu) containing 1 Hs.408629 [show with all ESTs]Unigene Representative Sequence: BC0518604 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000376004(uc001vpq.4 uc001vpr.4) ENST00000460338 ENST00000484943
ENST00000486540
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KDELC1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KDELC1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KDELC1 (NM_024089) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KDELC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDELC1 |
Additional cDNA sequence: AK074974.1 AK222567.1 AK225103.1 AK309238.1 AY358959.1 BC001297.1 BC051860.1 4 DOTS entries: DT.75131188 DT.100776109 DT.100776108 DT.100776113 24/76 AceView cDNA sequences (see all 76): AY358959 BU184588 NM_024089 CA420666 AI700982 BU626007 AI092617 BC001297 BE502857 CR608890 BX098759 CR625522 AA704923 BP356722 CR609732 BQ448288 BP374225 AI061464 AI470553 CR605114 CR607417 AA626568 AI092391 AA977119
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for KDELC1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KDELC1
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Expression
for KDELC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KDELC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGTACTTT
About this image
See KDELC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KDELC1
SOURCE GeneReport for Unigene cluster: Hs.408629
SABiosciences Custom PCR Arrays for KDELC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KDELC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KDELC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KDELC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KDELC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDELC1 |
Orthologs
for KDELC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KDELC1 gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for KDELC1 (if available)
TreeFam Gene Tree for KDELC1 (if available) |
Paralogs
for KDELC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KDELC1 gene
- POGLUT12 KDELC22
2 SIMAP similar genes for KDELC1 using alignment to 2 protein entries: KDEL1_HUMAN (see all proteins):KDELC2 POGLUT1
KDELC1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for KDELC1
PGOHUM00000235750
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Genomic Variants
for KDELC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KDELC1 (103436631 - 103451404 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KDELC1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KDELC1 |
|
Disorders
/ Diseases
for KDELC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KDELC1 for disorders About GeneDecksing
OMIM gene information: 611613
OMIM disorders: --
1  disease for KDELC1: About MalaCardsbipolar disorder
Export disorders for KDELC1 gene to outside databases
|
Publications
for KDELC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KDELC1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with KDELC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Linkage disequilibrium analysis in the LOC93081-KDELC1-BIVM region on 13q in bipolar disorder. (PubMed id 15635705)1 Ferraren D.O....Detera-Wadleigh S.D. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Identification of a novel mammalian endoplasmic reticulum-resident KDEL protein using an EST database motif search. (PubMed id 11167020)1 Kimata Y....Kohno K. (2000)
|
External Searches for KDELC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KDELC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KDELC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KDELC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KDELC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KDELC1 gene:
Search GeneIP for patents involving KDELC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KDELC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KDELC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KDELC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KDELC1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KDELC1 | | OriGene 3'-UTR Clone for KDELC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KDELC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KDELC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KDELC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KDELC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KDELC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KDELC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KDELC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KDELC1 |
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 |  |  |  | |
| | | | Search Tocris compounds for KDELC1 |
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 | | | KDELC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KDELC1 |
|  |  |  |  | | | | ThermoFisher Antibody for KDELC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KDELC1 |
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