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Aliases for KCTD9 Gene

Aliases for KCTD9 Gene

  • Potassium Channel Tetramerization Domain Containing 9 2 3 5
  • Potassium Channel Tetramerisation Domain Containing 9 2 3
  • BTBD27 3

External Ids for KCTD9 Gene

Previous GeneCards Identifiers for KCTD9 Gene

  • GC08M025307
  • GC08M025341
  • GC08M023830
  • GC08M025285

Summaries for KCTD9 Gene

GeneCards Summary for KCTD9 Gene

KCTD9 (Potassium Channel Tetramerization Domain Containing 9) is a Protein Coding gene. Among its related pathways are Hepatic ABC Transporters and Sweet Taste Signaling. An important paralog of this gene is KCTD5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD9 Gene

Genomics for KCTD9 Gene

Regulatory Elements for KCTD9 Gene

Promoters for KCTD9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KCTD9 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCTD9 Gene

Chromosome:
8
Start:
25,427,842 bp from pter
End:
25,458,476 bp from pter
Size:
30,635 bases
Orientation:
Minus strand

Genomic View for KCTD9 Gene

Genes around KCTD9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD9 Gene

Proteins for KCTD9 Gene

  • Protein details for KCTD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L273-KCTD9_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein KCTD9
    Protein Accession:
    Q7L273
    Secondary Accessions:
    • Q6NUM8
    • Q9NXV4

    Protein attributes for KCTD9 Gene

    Size:
    389 amino acids
    Molecular mass:
    42567 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90904.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KCTD9 Gene

neXtProt entry for KCTD9 Gene

Proteomics data for KCTD9 Gene at MOPED

Post-translational modifications for KCTD9 Gene

  • Ubiquitination at Lys 371
  • Modification sites at PhosphoSitePlus

Other Protein References for KCTD9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCTD9 Gene

Domains & Families for KCTD9 Gene

Gene Families for KCTD9 Gene

Suggested Antigen Peptide Sequences for KCTD9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L273

UniProtKB/Swiss-Prot:

KCTD9_HUMAN :
  • Contains 1 BTB (POZ) domain.
Domain:
  • Contains 1 BTB (POZ) domain.
  • Contains 1 KHA domain.
  • Contains 3 pentapeptide repeat domains.
genes like me logo Genes that share domains with KCTD9: view

Function for KCTD9 Gene

genes like me logo Genes that share phenotypes with KCTD9: view

Animal Model Products

miRNA for KCTD9 Gene

miRTarBase miRNAs that target KCTD9

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD9 Gene

Localization for KCTD9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCTD9 Gene COMPARTMENTS Subcellular localization image for KCTD9 gene
Compartment Confidence
cytosol 3
mitochondrion 3
nucleus 3
cytoskeleton 2
extracellular 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD9 Gene

Pathways & Interactions for KCTD9 Gene

genes like me logo Genes that share pathways with KCTD9: view

Pathways by source for KCTD9 Gene

Gene Ontology (GO) - Biological Process for KCTD9 Gene

None

No data available for SIGNOR curated interactions for KCTD9 Gene

Drugs & Compounds for KCTD9 Gene

No Compound Related Data Available

Transcripts for KCTD9 Gene

Unigene Clusters for KCTD9 Gene

Potassium channel tetramerisation domain containing 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD9 Gene

No ASD Table

Relevant External Links for KCTD9 Gene

GeneLoc Exon Structure for
KCTD9
ECgene alternative splicing isoforms for
KCTD9

Expression for KCTD9 Gene

mRNA expression in normal human tissues for KCTD9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KCTD9 Gene

This gene is overexpressed in Testis (36.4) and Seminal vesicle (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCTD9 Gene



SOURCE GeneReport for Unigene cluster for KCTD9 Gene Hs.72071

genes like me logo Genes that share expression patterns with KCTD9: view

Protein tissue co-expression partners for KCTD9 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KCTD9 Gene

Orthologs for KCTD9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KCTD9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD9 36
  • 100 (a)
OneToOne
KCTD9 35
  • 99.91 (n)
  • 99.74 (a)
cow
(Bos Taurus)
Mammalia KCTD9 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCTD9 36
  • 96 (a)
OneToOne
KCTD9 35
  • 96.25 (n)
  • 99.2 (a)
mouse
(Mus musculus)
Mammalia Kctd9 16
Kctd9 36
  • 98 (a)
OneToOne
Kctd9 35
  • 91.43 (n)
  • 98.46 (a)
oppossum
(Monodelphis domestica)
Mammalia KCTD9 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCTD9 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kctd9 35
  • 91.43 (n)
  • 98.46 (a)
chicken
(Gallus gallus)
Aves KCTD9 35
  • 82.43 (n)
  • 96.14 (a)
KCTD9 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCTD9 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd9 35
  • 73.26 (n)
  • 85.6 (a)
Str.3830 35
zebrafish
(Danio rerio)
Actinopterygii zgc:113115 35
  • 74.04 (n)
  • 87.66 (a)
kctd9 36
  • 85 (a)
OneToMany
KCTD9 (2 of 2) 36
  • 87 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000478 35
  • 51.64 (n)
  • 50.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14647 35
  • 56.05 (n)
  • 57.96 (a)
CG14647 36
  • 55 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons FIP2 35
  • 47.24 (n)
  • 35.25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10153 36
  • 56 (a)
OneToOne
Species with no ortholog for KCTD9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCTD9 Gene

ENSEMBL:
Gene Tree for KCTD9 (if available)
TreeFam:
Gene Tree for KCTD9 (if available)

Paralogs for KCTD9 Gene

Paralogs for KCTD9 Gene

(1) SIMAP similar genes for KCTD9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCTD9: view

Variants for KCTD9 Gene

Sequence variations from dbSNP and Humsavar for KCTD9 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1827957 -- 25,428,755(-) AAAAA(C/T)AGACG utr-variant-3-prime
rs1812594 -- 25,429,881(-) CCACT(A/G)CACAT reference, synonymous-codon
rs2321050 -- 25,428,081(+) ATCTG(C/T)AGTTT utr-variant-3-prime
rs2321051 -- 25,428,097(+) CACAC(C/T)ATGTT utr-variant-3-prime
rs2321052 -- 25,428,164(+) TGAAT(A/G)AATAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KCTD9 Gene

Variant ID Type Subtype PubMed ID
nsv890689 CNV Gain 21882294
nsv6125 CNV Insertion 18451855
essv1351 CNV CNV 17122850

Variation tolerance for KCTD9 Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD9 Gene

HapMap Linkage Disequilibrium report
KCTD9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD9 Gene

Disorders for KCTD9 Gene

Relevant External Links for KCTD9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCTD9

No disorders were found for KCTD9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD9 Gene

Publications for KCTD9 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PMID: 11483580) Yu Y. … He F. (Genome Res. 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for KCTD9 Gene

Sources for KCTD9 Gene

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