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Aliases for KCTD9 Gene

Aliases for KCTD9 Gene

  • Potassium Channel Tetramerization Domain Containing 9 2 3 5
  • Potassium Channel Tetramerisation Domain Containing 9 2 3
  • BTB/POZ Domain-Containing Protein KCTD9 3
  • BTBD27 3

External Ids for KCTD9 Gene

Previous GeneCards Identifiers for KCTD9 Gene

  • GC08M025307
  • GC08M025341
  • GC08M023830
  • GC08M025285

Summaries for KCTD9 Gene

GeneCards Summary for KCTD9 Gene

KCTD9 (Potassium Channel Tetramerization Domain Containing 9) is a Protein Coding gene. Among its related pathways are Hepatic ABC Transporters and Sweet Taste Signaling. An important paralog of this gene is KCTD2.

UniProtKB/Swiss-Prot for KCTD9 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.

Additional gene information for KCTD9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD9 Gene

Genomics for KCTD9 Gene

Regulatory Elements for KCTD9 Gene

Enhancers for KCTD9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H025478 1.1 Ensembl ENCODE 21.6 -22.2 -22153 5 FOXA2 ZBTB21 INSM2 KLF17 ZIC2 ZNF324 HIC1 ZFHX2 POLR2A FOS KCTD9 CDCA2 GC08P025504
GH08H025392 1.1 ENCODE dbSUPER 19.1 +65.4 65407 1 SOX13 TFAP4 FOXA2 SAP130 ZNF384 RARA TEAD3 NR2F6 SOX5 GATAD2A KCTD9 GNRH1 CDCA2 PIR37075 GC08P025414
GH08H025236 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +220.0 219999 3 ELF3 FOXA2 ATF1 ZSCAN4 ARID4B RAD21 THRB ZSCAN9 RARA ATF7 DOCK5 KCTD9 CDCA2 GC08M025303
GH08H025453 1.4 Ensembl ENCODE 10.8 +1.2 1238 6 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B GNRH1 ENSG00000253476 KCTD9 LOC105379337 NEFM GC08P025445
GH08H025318 1.4 Ensembl ENCODE dbSUPER 10.4 +138.9 138902 2 ELF3 FOXA2 SIN3A RAD21 RARA YY1 FOS CREM THAP11 CEBPB GNRH1 CDCA2 KCTD9 GC08M025315 GC08M025303
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCTD9 on UCSC Golden Path with GeneCards custom track

Promoters for KCTD9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000222426 176 4201 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B

Genomic Location for KCTD9 Gene

Chromosome:
8
Start:
25,427,842 bp from pter
End:
25,458,476 bp from pter
Size:
30,635 bases
Orientation:
Minus strand

Genomic View for KCTD9 Gene

Genes around KCTD9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD9 Gene

Proteins for KCTD9 Gene

  • Protein details for KCTD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L273-KCTD9_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein KCTD9
    Protein Accession:
    Q7L273
    Secondary Accessions:
    • Q6NUM8
    • Q9NXV4

    Protein attributes for KCTD9 Gene

    Size:
    389 amino acids
    Molecular mass:
    42567 Da
    Quaternary structure:
    • Forms pentamers. Component of a complex composed of 5 subunits of KCTD9 and 5 CUL3.
    SequenceCaution:
    • Sequence=BAA90904.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KCTD9 Gene

neXtProt entry for KCTD9 Gene

Post-translational modifications for KCTD9 Gene

  • Ubiquitination at isoforms=371
  • Modification sites at PhosphoSitePlus

Other Protein References for KCTD9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCTD9 Gene

Domains & Families for KCTD9 Gene

Gene Families for KCTD9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KCTD9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KCTD9: view

No data available for UniProtKB/Swiss-Prot for KCTD9 Gene

Function for KCTD9 Gene

Molecular function for KCTD9 Gene

UniProtKB/Swiss-Prot Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.

Gene Ontology (GO) - Molecular Function for KCTD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IPI 21516116
GO:0043621 protein self-association IDA 26334369
GO:0097602 cullin family protein binding IDA 26334369
genes like me logo Genes that share ontologies with KCTD9: view
genes like me logo Genes that share phenotypes with KCTD9: view

Animal Model Products

CRISPR Products

miRNA for KCTD9 Gene

miRTarBase miRNAs that target KCTD9

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KCTD9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD9 Gene

Localization for KCTD9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD9 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 3
cytoskeleton 2
extracellular 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Intermediate filaments (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KCTD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with KCTD9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KCTD9 Gene

Pathways & Interactions for KCTD9 Gene

genes like me logo Genes that share pathways with KCTD9: view

UniProtKB/Swiss-Prot Q7L273-KCTD9_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for KCTD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD9: view

No data available for SIGNOR curated interactions for KCTD9 Gene

Drugs & Compounds for KCTD9 Gene

No Compound Related Data Available

Transcripts for KCTD9 Gene

Unigene Clusters for KCTD9 Gene

Potassium channel tetramerisation domain containing 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KCTD9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD9 Gene

No ASD Table

Relevant External Links for KCTD9 Gene

GeneLoc Exon Structure for
KCTD9
ECgene alternative splicing isoforms for
KCTD9

Expression for KCTD9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCTD9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KCTD9 Gene

This gene is overexpressed in Testis (36.4) and Seminal vesicle (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KCTD9 Gene



Protein tissue co-expression partners for KCTD9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KCTD9 Gene:

KCTD9

SOURCE GeneReport for Unigene cluster for KCTD9 Gene:

Hs.72071

Evidence on tissue expression from TISSUES for KCTD9 Gene

  • Intestine(4.2)
genes like me logo Genes that share expression patterns with KCTD9: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCTD9 Gene

Orthologs for KCTD9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KCTD9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD9 33 34
  • 99.91 (n)
cow
(Bos Taurus)
Mammalia KCTD9 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCTD9 34 33
  • 96.25 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCTD9 34
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCTD9 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kctd9 33 16 34
  • 91.43 (n)
rat
(Rattus norvegicus)
Mammalia Kctd9 33
  • 91.43 (n)
chicken
(Gallus gallus)
Aves KCTD9 33 34
  • 82.43 (n)
lizard
(Anolis carolinensis)
Reptilia KCTD9 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd9 33
  • 73.26 (n)
Str.3830 33
zebrafish
(Danio rerio)
Actinopterygii KCTD9 (2 of 2) 34
  • 87 (a)
OneToMany
kctd9 34
  • 85 (a)
OneToMany
zgc:113115 33
  • 74.04 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14647 33 34
  • 56.05 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000478 33
  • 51.64 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons FIP2 33
  • 47.24 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10153 34
  • 56 (a)
OneToOne
Species where no ortholog for KCTD9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCTD9 Gene

ENSEMBL:
Gene Tree for KCTD9 (if available)
TreeFam:
Gene Tree for KCTD9 (if available)

Paralogs for KCTD9 Gene

Paralogs for KCTD9 Gene

(1) SIMAP similar genes for KCTD9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCTD9: view

Variants for KCTD9 Gene

Sequence variations from dbSNP and Humsavar for KCTD9 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs71551806 Likely benign 25,424,356(+) TTTTT(-/T)AATGG downstream-variant-500B, utr-variant-5-prime
rs534899690 Uncertain significance 25,424,007(+) CACTG(G/T)TCGAT intron-variant, downstream-variant-500B, utr-variant-5-prime
rs78322917 Uncertain significance 25,424,196(+) AGCCT(G/T)TTACC intron-variant, downstream-variant-500B, utr-variant-5-prime
rs886062840 Uncertain significance 25,424,357(-) AAAAA(-/A)GCATA nc-transcript-variant, utr-variant-5-prime
rs1000194807 -- 25,446,958(+) ATACA(C/T)GCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD9 Gene

Variant ID Type Subtype PubMed ID
dgv7148n100 CNV gain 25217958
esv2759606 CNV loss 17122850
esv3616666 OTHER inversion 21293372
nsv1031153 CNV gain 25217958
nsv1076073 CNV deletion 25765185
nsv1112960 CNV deletion 24896259
nsv1126851 CNV deletion 24896259
nsv6125 CNV insertion 18451855
nsv967571 CNV duplication 23825009
nsv981920 CNV duplication 23825009

Variation tolerance for KCTD9 Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCTD9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD9 Gene

Disorders for KCTD9 Gene

Relevant External Links for KCTD9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCTD9

No disorders were found for KCTD9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD9 Gene

Publications for KCTD9 Gene

  1. Structural Insights into KCTD Protein Assembly and Cullin3 Recognition. (PMID: 26334369) Ji AX … Privé GG (Journal of molecular biology 2016) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PMID: 11483580) Yu Y … He F (Genome research 2001) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for KCTD9 Gene

Sources for KCTD9 Gene

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