KCTD9 Gene
protein-coding GIFtS: 46
GCID: GC08M025341
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potassium channel tetramerisation domain containing 9
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Aliases
for KCTD9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Potassium Channel Tetramerisation Domain Containing 91 2 | | BTBD271 2 | | FLJ200381 | | BTB/POZ Domain-Containing Protein KCTD92 |
Export aliases for KCTD9 gene to outside databasesPrevious GC identifers: GC08M025307 GC08M023830 |
Summaries
for KCTD9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KCTD9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCTD9 gene promoter:
TBP Sp1 FOXO3 NF-kappaB FOXO3b C/EBPalpha FOXO3a Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCTD9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p21.1 Ensembl cytogenetic band: 8p21.2 HGNC cytogenetic band: 8p21.1KCTD9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M025341: view genomic region
(about GC identifiers)
Start:
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25,285,363 bp from pter |
End:
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25,315,992 bp from pter |
Size:
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30,630 bases |
Orientation:
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minus strand |
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Proteins
for KCTD9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KCTD9_HUMAN, Q7L273 (See
protein sequence)Recommended Name: BTB/POZ domain-containing protein KCTD9 Size: 389 amino acids; 42567 Da
Sequence caution: Sequence=BAA90904.1; Type=Erroneous initiation;
Secondary accessions: Q6NUM8 Q9NXV4Explore the universe of human proteins at neXtProt for KCTD9: NX_Q7L273
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7L273
KCTD9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060104.2
ENSEMBL proteins: ENSP00000221200 ENSP00000466874 ENSP00000467904
Human Recombinant Protein Products:
KCTD9 Antibody Products:
Assay Products for KCTD9: |
Protein
Domains /
Families
for KCTD9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCTD9 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7L273ProtoNet protein and cluster: Q7L273 2 Blocks protein families: IPB000210 BTB/POZ domain IPB001646 Pentapeptide repeat
UniProtKB/Swiss-Prot: KCTD9_HUMAN, Q7L273Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 1 KHA domainSimilarity: Contains 3 pentapeptide repeat domains |
Function
for KCTD9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD9 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KCTD9 (NM_017634) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCTD9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD9 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD9 |
|
Pathways & Interactions
for KCTD9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sweet Taste Signaling | | | 2 | Activation of cAMP-Dependent PKA | | | 3 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | | | 4 | Hepatic ABC Transporters | |
5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCTD9 (see all 13)
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCTD9
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for KCTD9 (Q7L2733 ENSP000002212004) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051260 | protein homooligomerization |
IEA | -- |
KCTD9 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCTD9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KCTD9
Search CenterWatch for drugs/clinical trials and news about KCTD9
|
Transcripts
for KCTD9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KCTD9 gene: NM_017634.3 Unigene Clusters for KCTD9: Potassium channel tetramerisation domain containing 9 Hs.72071 [show with all ESTs], Hs.188763 [show with all ESTs]Unigene Representative Sequences: NM_017634, BQ21963311 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000221200(uc011lad.2 uc003xeo.3) ENST00000519665 ENST00000523140
ENST00000522493 ENST00000518067 ENST00000518997 ENST00000523294 ENST00000521458
ENST00000524217 ENST00000520405 ENST00000517914
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD9 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KCTD9 (NM_017634) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCTD9 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD9 |
Additional cDNA sequence: AK298518.1 BC021216.2 12 DOTS entries: DT.311533 DT.91924119 DT.99927591 DT.100770239 DT.121469138 DT.121469151 DT.100700232 DT.40286472 DT.86841883 DT.97843817 DT.97843819 DT.121294997 24/135 AceView cDNA sequences (see all 135): BM669215 BM995083 BM991759 BM980234 AW292224 BU178348 AA936810 BU149129 AI125769 AI696400 BQ014110 NM_017634 CA450242 AA366987 CA445587 BE222126 AI374591 BM995898 AI278056 AF075015 BC021216 AL528772 BX282153 AA398524
GeneLoc Exon Structure
|
Expression
for KCTD9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KCTD9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTGCTTAG
About this image
See KCTD9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCTD9
SOURCE GeneReport for Unigene clusters: Hs.72071 Hs.188763
SABiosciences Custom PCR Arrays for KCTD9
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCTD9
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCTD9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD9 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD9 |
Orthologs
for KCTD9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KCTD9 gene from 8/20 species (see all 20) About this table
ENSEMBL Gene Tree for KCTD9 (if available)
TreeFam Gene Tree for KCTD9 (if available) |
Paralogs
for KCTD9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KCTD9 gene
- KCTD172 KCTD52 KCTD22
1 SIMAP similar gene for KCTD9 using alignment to 3 protein entries: KCTD9_HUMAN (see all proteins):KCTD5
KCTD9 for paralogs About GeneDecksing
5/7 Pseudogenes.org Pseudogenes for KCTD9 (see all 7)
PGOHUM00000238729 PGOHUM00000257923 PGOHUM00000237281 PGOHUM00000235191 PGOHUM00000257186
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Genomic Variants
for KCTD9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KCTD9 (25285363 - 25315992 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KCTD9
1 CNV: 3727 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCTD9 |
|
Disorders
/ Diseases
for KCTD9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KCTD9 for disorders About GeneDecksing
3  diseases for KCTD9: About MalaCardsviral hepatitis hepatitis b hepatitis
1 disease from the University of Copenhagen DISEASES database for KCTD9:Viral hepatitis Export disorders for KCTD9 gene to outside databases
|
Publications
for KCTD9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KCTD9 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with KCTD9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PubMed id 11483580)1, 3 Yu Y....He F. (2001)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- [Increased expression of KCTD9, a novel potassium channel related gene, correlates with disease severity in patients with viral hepatitis B] (PubMed id 19032868)1 Zhou Y.Y....Ning Q. (2008)
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External Searches for KCTD9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing KCTD9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCTD9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCTD9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KCTD9 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KCTD9 gene:
Search GeneIP for patents involving KCTD9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCTD9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KCTD9 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCTD9 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCTD9 | | | OriGene Protein Over-expression Lysate for KCTD9 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KCTD9 | | OriGene 3'-UTR Clone for KCTD9 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD9 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD9 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for KCTD9 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KCTD9 | | OriGene Custom Protein Services for KCTD9 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCTD9 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCTD9 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD9 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCTD9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD9 |
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| | | | Search Tocris compounds for KCTD9 |
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 | | | KCTD9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD9 |
|  |  |  | | | | Search ThermoFisher Antibodies for KCTD9 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD9 |
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