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Aliases for KCTD8 Gene

Aliases for KCTD8 Gene

  • Potassium Channel Tetramerization Domain Containing 8 2 3
  • Potassium Channel Tetramerisation Domain Containing 8 2

External Ids for KCTD8 Gene

Previous GeneCards Identifiers for KCTD8 Gene

  • GC04U900183
  • GC04M044017
  • GC04M043870
  • GC04M043497

Summaries for KCTD8 Gene

GeneCards Summary for KCTD8 Gene

KCTD8 (Potassium Channel Tetramerization Domain Containing 8) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. An important paralog of this gene is KCTD11.

UniProtKB/Swiss-Prot for KCTD8 Gene

  • Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD8 Gene

Genomics for KCTD8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCTD8 Gene

Start:
44,173,903 bp from pter
End:
44,448,807 bp from pter
Size:
274,905 bases
Orientation:
Minus strand

Genomic View for KCTD8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCTD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD8 Gene

Proteins for KCTD8 Gene

  • Protein details for KCTD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZWB6-KCTD8_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein KCTD8
    Protein Accession:
    Q6ZWB6
    Secondary Accessions:
    • A2RU39

    Protein attributes for KCTD8 Gene

    Size:
    473 amino acids
    Molecular mass:
    52440 Da
    Quaternary structure:
    • Interacts as a tetramer with GABRB1 and GABRB2.

neXtProt entry for KCTD8 Gene

Proteomics data for KCTD8 Gene at MOPED

Post-translational modifications for KCTD8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCTD8 Gene

Domains for KCTD8 Gene

Protein Domains for KCTD8 Gene

Suggested Antigen Peptide Sequences for KCTD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZWB6

UniProtKB/Swiss-Prot:

KCTD8_HUMAN :
  • Q6ZWB6
Domain:
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD8: view

No data available for Gene Families for KCTD8 Gene

Function for KCTD8 Gene

Molecular function for KCTD8 Gene

UniProtKB/Swiss-Prot Function: Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).

Gene Ontology (GO) - Molecular Function for KCTD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KCTD8: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCTD8 Gene

Localization for KCTD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCTD8 Gene

Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCTD8 Gene COMPARTMENTS Subcellular localization image for KCTD8 gene
Compartment Confidence
nucleus 3
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for KCTD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030054 cell junction IEA --
GO:0042734 presynaptic membrane IEA --
GO:0043235 receptor complex IEA --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with KCTD8: view

Pathways for KCTD8 Gene

genes like me logo Genes that share pathways with KCTD8: view

Interacting Proteins for KCTD8 Gene

Gene Ontology (GO) - Biological Process for KCTD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD8: view

Transcripts for KCTD8 Gene

mRNA/cDNA for KCTD8 Gene

(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCTD8 Gene

Potassium channel tetramerisation domain containing 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCTD8

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KCTD8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD8 Gene

No ASD Table

Relevant External Links for KCTD8 Gene

GeneLoc Exon Structure for
KCTD8
ECgene alternative splicing isoforms for
KCTD8

Expression for KCTD8 Gene

mRNA expression in normal human tissues for KCTD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCTD8 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (6.5), Brain - Cerebellum (6.1), and Brain - Nucleus accumbens (basal ganglia) (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCTD8 Gene

SOURCE GeneReport for Unigene cluster for KCTD8 Gene Hs.479644

genes like me logo Genes that share expressions with KCTD8: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KCTD8 Gene

Orthologs for KCTD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD8 35
  • 99.51 (n)
  • 100 (a)
KCTD8 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCTD8 35
  • 93.83 (n)
  • 97.45 (a)
KCTD8 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCTD8 35
  • 86.52 (n)
  • 85.81 (a)
KCTD8 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kctd8 35
  • 88.58 (n)
  • 94.93 (a)
Kctd8 16
Kctd8 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCTD8 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kctd8 35
  • 88.02 (n)
  • 94.08 (a)
chicken
(Gallus gallus)
Aves KCTD8 35
  • 83.18 (n)
  • 89.17 (a)
KCTD8 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCTD8 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd8 35
  • 72.08 (n)
  • 80.43 (a)
zebrafish
(Danio rerio)
Actinopterygii kctd8 35
  • 69.78 (n)
  • 79.14 (a)
kctd8 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000805 35
  • 61.34 (n)
  • 52.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10830 35
  • 59.7 (n)
  • 50.91 (a)
CG10830 36
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F32B4.5 36
  • 21 (a)
OneToMany
VM106R.1 35
  • 50.55 (n)
  • 45.49 (a)
Species with no ortholog for KCTD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD8 Gene

ENSEMBL:
Gene Tree for KCTD8 (if available)
TreeFam:
Gene Tree for KCTD8 (if available)

Paralogs for KCTD8 Gene

Paralogs for KCTD8 Gene

Selected SIMAP similar genes for KCTD8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCTD8: view

Variants for KCTD8 Gene

Sequence variations from dbSNP and Humsavar for KCTD8 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs716890 -- 44,188,377(-) AAGCA(A/C)AATTC intron-variant
rs718416 -- 44,318,716(+) TTAAA(G/T)TTTGA intron-variant
rs902406 -- 44,255,444(-) TAACA(A/C)AATTT intron-variant
rs902407 -- 44,255,418(-) AATGT(A/G)TAAGG intron-variant
rs937061 -- 44,178,713(-) AATTG(G/T)CTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD8 Gene

Variant ID Type Subtype PubMed ID
esv269221 CNV Insertion 20981092
esv2727505 CNV Deletion 23290073
esv2727506 CNV Deletion 23290073
esv4811 CNV Deletion 18987735
nsv292914 CNV Loss 16902084
nsv4317 CNV Loss 18451855
nsv878978 CNV Loss 21882294
esv2665137 CNV Deletion 23128226
esv28915 CNV Loss 19812545
nsv526878 CNV Gain 19592680
esv271008 CNV Insertion 20981092
esv2467772 CNV Deletion 19546169
esv2157507 CNV Deletion 18987734
esv2518487 CNV Deletion 19546169
esv23034 CNV Loss 19812545
nsv441874 CNV CNV 18776908
esv2676713 CNV Deletion 23128226
nsv514212 CNV Loss 21397061
nsv517413 CNV Loss 19592680
esv2668101 CNV Deletion 23128226
nsv520405 CNV Loss 19592680
nsv512825 CNV Insertion 21212237
esv1503360 CNV Insertion 17803354
nsv4318 CNV Insertion 18451855

Relevant External Links for KCTD8 Gene

HapMap Linkage Disequilibrium report
KCTD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD8 Gene

Disorders for KCTD8 Gene

Relevant External Links for KCTD8

Genetic Association Database (GAD)
KCTD8
genes like me logo Genes that share disorders with KCTD8: view

No data available for UniProtKB/Swiss-Prot for KCTD8 Gene

Publications for KCTD8 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. KCTD8 gene and brain growth in adverse intrauterine environment: a genome-wide association study. (PMID: 22156575) Paus T. … Pausova Z. (Cereb. Cortex 2012) 3
  3. A genome-wide association study of the Protein C anticoagulant pathway. (PMID: 22216198) Athanasiadis G. … Soria J.M. (PLoS ONE 2011) 3
  4. Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis. (PMID: 22930747) Faryna M. … Gerhauser C. (FASEB J. 2012) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for KCTD8 Gene

Sources for KCTD8 Gene

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