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Aliases for KCTD8 Gene

Aliases for KCTD8 Gene

  • Potassium Channel Tetramerization Domain Containing 8 2 3 5
  • Potassium Channel Tetramerisation Domain Containing 8 2

External Ids for KCTD8 Gene

Previous GeneCards Identifiers for KCTD8 Gene

  • GC04U900183
  • GC04M044017
  • GC04M043870
  • GC04M043497

Summaries for KCTD8 Gene

GeneCards Summary for KCTD8 Gene

KCTD8 (Potassium Channel Tetramerization Domain Containing 8) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. An important paralog of this gene is KCTD11.

UniProtKB/Swiss-Prot for KCTD8 Gene

  • Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD8 Gene

Genomics for KCTD8 Gene

Regulatory Elements for KCTD8 Gene

Enhancers for KCTD8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCTD8 on UCSC Golden Path with GeneCards custom track

Promoters for KCTD8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KCTD8 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCTD8 Gene

44,173,903 bp from pter
44,448,885 bp from pter
274,983 bases
Minus strand

Genomic View for KCTD8 Gene

Genes around KCTD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD8 Gene

Proteins for KCTD8 Gene

  • Protein details for KCTD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD8
    Protein Accession:
    Secondary Accessions:
    • A2RU39

    Protein attributes for KCTD8 Gene

    473 amino acids
    Molecular mass:
    52440 Da
    Quaternary structure:
    • Interacts as a tetramer with GABRB1 and GABRB2.

neXtProt entry for KCTD8 Gene

Proteomics data for KCTD8 Gene at MOPED

Post-translational modifications for KCTD8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCTD8 Gene

Domains & Families for KCTD8 Gene

Protein Domains for KCTD8 Gene

Suggested Antigen Peptide Sequences for KCTD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD8: view

No data available for Gene Families for KCTD8 Gene

Function for KCTD8 Gene

Molecular function for KCTD8 Gene

UniProtKB/Swiss-Prot Function:
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).
genes like me logo Genes that share phenotypes with KCTD8: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KCTD8 Gene

Localization for KCTD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCTD8 Gene

Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane.

Subcellular locations from

Jensen Localization Image for KCTD8 Gene COMPARTMENTS Subcellular localization image for KCTD8 gene
Compartment Confidence
nucleus 3
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for KCTD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with KCTD8: view

Pathways & Interactions for KCTD8 Gene

genes like me logo Genes that share pathways with KCTD8: view

Interacting Proteins for KCTD8 Gene

Gene Ontology (GO) - Biological Process for KCTD8 Gene


No data available for SIGNOR curated interactions for KCTD8 Gene

Drugs & Compounds for KCTD8 Gene

No Compound Related Data Available

Transcripts for KCTD8 Gene

mRNA/cDNA for KCTD8 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCTD8 Gene

Potassium channel tetramerisation domain containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD8 Gene

No ASD Table

Relevant External Links for KCTD8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD8 Gene

mRNA expression in normal human tissues for KCTD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCTD8 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.5), Brain - Cerebellum (x6.1), and Brain - Nucleus accumbens (basal ganglia) (x4.8).

Protein differential expression in normal tissues from HIPED for KCTD8 Gene

This gene is overexpressed in Frontal cortex (27.1), Brain (26.2), and Fetal Brain (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCTD8 Gene

SOURCE GeneReport for Unigene cluster for KCTD8 Gene Hs.479644

genes like me logo Genes that share expression patterns with KCTD8: view

Protein tissue co-expression partners for KCTD8 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for KCTD8 Gene

Orthologs for KCTD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCTD8 35
  • 93.83 (n)
  • 97.45 (a)
KCTD8 36
  • 97 (a)
(Canis familiaris)
Mammalia KCTD8 35
  • 86.52 (n)
  • 85.81 (a)
KCTD8 36
  • 87 (a)
(Mus musculus)
Mammalia Kctd8 35
  • 88.58 (n)
  • 94.93 (a)
Kctd8 16
Kctd8 36
  • 95 (a)
(Pan troglodytes)
Mammalia KCTD8 35
  • 99.51 (n)
  • 100 (a)
KCTD8 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Kctd8 35
  • 88.02 (n)
  • 94.08 (a)
(Monodelphis domestica)
Mammalia KCTD8 36
  • 93 (a)
(Gallus gallus)
Aves KCTD8 35
  • 83.18 (n)
  • 89.17 (a)
KCTD8 36
  • 89 (a)
(Anolis carolinensis)
Reptilia KCTD8 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd8 35
  • 72.08 (n)
  • 80.43 (a)
(Danio rerio)
Actinopterygii kctd8 35
  • 69.78 (n)
  • 79.14 (a)
kctd8 36
  • 69 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000805 35
  • 61.34 (n)
  • 52.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10830 35
  • 59.7 (n)
  • 50.91 (a)
CG10830 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea VM106R.1 35
  • 50.55 (n)
  • 45.49 (a)
F32B4.5 36
  • 21 (a)
Species with no ortholog for KCTD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD8 Gene

Gene Tree for KCTD8 (if available)
Gene Tree for KCTD8 (if available)

Paralogs for KCTD8 Gene

Paralogs for KCTD8 Gene

(2) SIMAP similar genes for KCTD8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCTD8: view

Variants for KCTD8 Gene

Sequence variations from dbSNP and Humsavar for KCTD8 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs13115990 - 44,175,226(+) GTTTA(A/G)GTGAT reference, missense
rs977336 -- 44,275,724(+) TGGTT(A/C)TAGAA intron-variant
rs983306 -- 44,207,567(-) ATGTG(C/G)AGGGA intron-variant
rs983363 -- 44,204,005(-) GTTAT(A/G/T)TAGAT intron-variant
rs985188 -- 44,233,845(+) GTAGA(A/C)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD8 Gene

Variant ID Type Subtype PubMed ID
esv269221 CNV Insertion 20981092
esv2727505 CNV Deletion 23290073
esv2727506 CNV Deletion 23290073
esv4811 CNV Deletion 18987735
nsv292914 CNV Loss 16902084
nsv4317 CNV Loss 18451855
nsv878978 CNV Loss 21882294
esv2665137 CNV Deletion 23128226
esv28915 CNV Loss 19812545
nsv526878 CNV Gain 19592680
esv271008 CNV Insertion 20981092
esv2467772 CNV Deletion 19546169
esv2157507 CNV Deletion 18987734
esv2518487 CNV Deletion 19546169
esv23034 CNV Loss 19812545
nsv441874 CNV CNV 18776908
esv2676713 CNV Deletion 23128226
nsv514212 CNV Loss 21397061
nsv517413 CNV Loss 19592680
esv2668101 CNV Deletion 23128226
nsv520405 CNV Loss 19592680
nsv512825 CNV Insertion 21212237
esv1503360 CNV Insertion 17803354
nsv4318 CNV Insertion 18451855

Variation tolerance for KCTD8 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KCTD8 Gene

Disorders for KCTD8 Gene

Relevant External Links for KCTD8

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KCTD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD8 Gene

Publications for KCTD8 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. KCTD8 gene and brain growth in adverse intrauterine environment: a genome-wide association study. (PMID: 22156575) Paus T. … Pausova Z. (Cereb. Cortex 2012) 3
  3. Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis. (PMID: 22930747) Faryna M. … Gerhauser C. (FASEB J. 2012) 3
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  5. Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13). (PMID: 22952603) Hart A.B. … Palmer A.A. (PLoS ONE 2012) 3

Products for KCTD8 Gene

Sources for KCTD8 Gene