KCTD8 Gene
protein-coding GIFtS: 41
GCID: GC04M044091
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potassium channel tetramerisation domain containing 8
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Aliases
for KCTD8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Potassium Channel Tetramerisation Domain Containing 81 2 | | BTB/POZ Domain-Containing Protein KCTD82 |
Export aliases for KCTD8 gene to outside databasesPrevious GC identifers: GC04U900183 GC04M044017 GC04M043870 GC04M043497 |
Summaries
for KCTD8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KCTD8_HUMAN, Q6ZWB6Function: Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response.Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset andpromoting desensitization (By similarity)
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Genomic Views
for KCTD8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006238.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCTD8 gene promoter:
Nkx3-1 COUP-TF1 NRSF form 1 COUP Nkx3-1 v1 POU6F1 (c2) HNF-4alpha2 NRSF form 2 HNF-4alpha1 COUP-TF
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCTD8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p13 Ensembl cytogenetic band: 4p13 HGNC cytogenetic band: 4p13KCTD8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M044091: view genomic region
(about GC identifiers)
Start:
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44,175,920 bp from pter |
End:
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44,450,824 bp from pter |
Size:
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274,905 bases |
Orientation:
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minus strand |
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Proteins
for KCTD8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KCTD8_HUMAN, Q6ZWB6 (See
protein sequence)Recommended Name: BTB/POZ domain-containing protein KCTD8 Size: 473 amino acids; 52440 Da
Subunit: Interacts as a tetramer with GABRB1 and GABRB2 (By similarity)
Subcellular location: Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse,postsynaptic cell membrane (By similarity)
Secondary accessions: A2RU39Explore the universe of human proteins at neXtProt for KCTD8: NX_Q6ZWB6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZWB6
KCTD8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_938167.1
ENSEMBL proteins: ENSP00000353129 ENSP00000424862
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
KCTD8 for ontologies About GeneDecksing
KCTD8 Antibody Products:
Assay Products for KCTD8: |
Protein
Domains /
Families
for KCTD8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCTD8 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6ZWB6ProtoNet protein and cluster: Q6ZWB6 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: KCTD8_HUMAN, Q6ZWB6Similarity: Contains 1 BTB (POZ) domain |
Function
for KCTD8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KCTD8_HUMAN, Q6ZWB6Function: Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response.Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset andpromoting desensitization (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KCTD8 (NM_198353) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCTD8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD8 |
|
Pathways & Interactions
for KCTD8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sweet Taste Signaling | | | 2 | Activation of cAMP-Dependent PKA | | | 3 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | | | 4 | Hepatic ABC Transporters | |
5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCTD8 (see all 13)
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCTD8
1 Interacting protein for KCTD8 (Q6ZWB63) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway |
IEA | -- | | GO:0051260 | protein homooligomerization |
IEA | -- |
KCTD8 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCTD8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KCTD8
Search CenterWatch for drugs/clinical trials and news about KCTD8
|
Transcripts
for KCTD8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KCTD8 gene: NM_198353.2 Unigene Cluster for KCTD8: Potassium channel tetramerisation domain containing 8 Hs.479644 [show with all ESTs]Unigene Representative Sequence: NM_1983532 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000360029(uc003gwu.3) ENST00000515268
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KCTD8 (NM_198353) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCTD8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD8 |
Additional cDNA sequence: AK123347.1 AK298831.1 BC132743.1 BC136793.1 2 DOTS entries: DT.40316884 DT.121269530 7 AceView cDNA sequences: AK123347 NM_198353 CA844212 T16697 BI601491 CA866432 H18367
GeneLoc Exon Structure
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Expression
for KCTD8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KCTD8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAATCAAAA
About this image
See KCTD8 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.479644
SABiosciences Custom PCR Arrays for KCTD8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCTD8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCTD8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD8 |
Orthologs
for KCTD8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KCTD8 gene from 4/18 species (see all 18) About this table
ENSEMBL Gene Tree for KCTD8 (if available)
TreeFam Gene Tree for KCTD8 (if available) |
Paralogs
for KCTD8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KCTD8 gene
- KCTD12 KCTD152 KCTD162 KCTD42 KCNRG2 KCTD122 KCTD112 KCTD212
- KCTD62 KCTD142
2 SIMAP similar genes for KCTD8 using alignment to 2 protein entries: KCTD8_HUMAN (see all proteins):KCTD16 KCTD12
KCTD8 for paralogs About GeneDecksing
|
Genomic Variants
for KCTD8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 18 variations for KCTD8
10 CNVs: 92068 23723 51410 92070 92071 51411 63814 38557 80276 63813
8 Indels: 80275 92069 98697 40622 41863 80277 12443 46649 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCTD8 |
|
Disorders
/ Diseases
for KCTD8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for KCTD8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KCTD8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KCTD8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A genome-wide association study of the Protein C antic oagulant pathway. (PubMed id 22216198)1 Athanasiadis G....Soria J.M. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for KCTD8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing KCTD8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCTD8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCTD8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KCTD8 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for KCTD8 gene:
Search GeneIP for patents involving KCTD8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCTD8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KCTD8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCTD8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCTD8 | | | OriGene Protein Over-expression Lysate for KCTD8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KCTD8 | | OriGene 3'-UTR Clone for KCTD8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCTD8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCTD8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCTD8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD8 |
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 |  |  |  | |
| | | | Search Tocris compounds for KCTD8 |
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 | | | KCTD8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD8 |
|  |  |  | | | | Search ThermoFisher Antibodies for KCTD8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD8 |
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