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KCTD6 Gene

protein-coding   GIFtS: 45
GCID: GC03P058452

Potassium Channel Tetramerization Domain Containing 6

(Previous name: potassium channel tetramerisation domain containing 6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Channel Tetramerization Domain Containing 61 2
Potassium Channel Tetramerisation Domain Containing 61 2
KCASH32
BTB/POZ Domain-Containing Protein KCTD62

External Ids:    HGNC: 222351   Entrez Gene: 2008452   Ensembl: ENSG000001683017   UniProtKB: Q8NC693   

Export aliases for KCTD6 gene to outside databases

Previous GC identifers: GC03P058435 GC03P058440


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KCTD6 Gene:
KCTD6 (potassium channel tetramerization domain containing 6) is a protein-coding gene. Diseases associated with KCTD6 include maturity-onset diabetes of the young, and cholera. An important paralog of this gene is KCTD1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCTD6 gene promoter:
         STAT5B   AREB6   HNF-1   MyoD   aMEF-2   HNF-1A   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KCTD6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCTD6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.3   Ensembl cytogenetic band:  3p14.3   HGNC cytogenetic band: 3p21.2

KCTD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCTD6 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P058452:  view genomic region     (about GC identifiers)

Start:
58,477,823 bp from pter      End:
58,488,087 bp from pter
Size:
10,265 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCTD6_HUMAN, Q8NC69 (See protein sequence)
Recommended Name: BTB/POZ domain-containing protein KCTD6  
Size: 237 amino acids; 27610 Da
Secondary accessions: B3KNI5 Q8NBS6 Q8TCA6

Explore the universe of human proteins at neXtProt for KCTD6: NX_Q8NC69

Explore proteomics data for KCTD6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KCTD6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001121686.1  NP_699162.3  

    ENSEMBL proteins: 
     ENSP00000384948   ENSP00000417490   ENSP00000442507   ENSP00000418999   ENSP00000347188  

    KCTD6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for KCTD6
    OriGene Protein Over-expression Lysate for KCTD6
    OriGene MassSpec for KCTD6
    OriGene Custom Protein Services for KCTD6
    GenScript Custom Purified and Recombinant Proteins Services for KCTD6
    Novus Biologicals KCTD6 Protein
    Novus Biologicals KCTD6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KCTD6

    KCTD6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KCTD6
    Novus Biologicals KCTD6 Antibodies
    Abcam antibodies for KCTD6
    Cloud-Clone Corp. Antibodies for KCTD6
    Search ThermoFisher Antibodies for KCTD6
    LSBio Antibodies in human, mouse, rat for KCTD6

    KCTD6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KCTD6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KCTD6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KCTD6
    Cloud-Clone Corp. CLIAs for KCTD6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003131 T1-type_BTB

    Graphical View of Domain Structure for InterPro Entry Q8NC69

    ProtoNet protein and cluster: Q8NC69

    UniProtKB/Swiss-Prot: KCTD6_HUMAN, Q8NC69
    Similarity: Contains 1 BTB (POZ) domain


    KCTD6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0030506ankyrin binding IDA--
         
    KCTD6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCTD6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KCTD6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCTD6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCTD6

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat KCTD6 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate KCTD6:
    hsa-miR-140-3p hsa-miR-153 hsa-miR-548v hsa-miR-1911*
    SwitchGear 3'UTR luciferase reporter plasmidKCTD6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KCTD6
    Predesigned siRNA for gene silencing in human, mouse, rat KCTD6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KCTD6

    Clone
    Products:
         
    OriGene clones in human, mouse for KCTD6 (see all 12)
    OriGene ORF clones in mouse, rat for KCTD6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): KCTD6 (NM_001128214)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCTD6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KCTD6
    Browse ESI BIO Cell Lines and PureStem Progenitors for KCTD6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCTD6 About    
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37
    Cellular Effects of Sildenafil0.46
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    4Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    MODY (Maturity-Onset Diabetes of Young)0.41

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KCTD6 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCTD6
    Interactions:

        Search GeneGlobe Interaction Network for KCTD6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for KCTD6 (Q8NC693 ENSP000003471884) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP11P517843, ENSP000002183484I2D: score=2 STRING: ENSP00000218348
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051260protein homooligomerization IEA--

    KCTD6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KCTD6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KCTD6 gene (2 alternative transcripts): 
    NM_001128214.1  NM_153331.3  

    Unigene Cluster for KCTD6:

    Potassium channel tetramerisation domain containing 6
    Hs.13982  [show with all ESTs]
    Unigene Representative Sequence: AK027572
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404589(uc003dkj.4) ENST00000490264 ENST00000491093 ENST00000479179
    ENST00000355076(uc003dkk.4) ENST00000479470
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KCTD6 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate KCTD6:
    hsa-miR-140-3p hsa-miR-153 hsa-miR-548v hsa-miR-1911*
    SwitchGear 3'UTR luciferase reporter plasmidKCTD6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KCTD6
    Predesigned siRNA for gene silencing in human, mouse, rat KCTD6
    Clone
    Products:
         
    OriGene clones in human, mouse for KCTD6 (see all 12)
    OriGene ORF clones in mouse, rat for KCTD6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): KCTD6 (NM_001128214)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCTD6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KCTD6
    OriGene qSTAR qPCR primer pairs in human, mouse for KCTD6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCTD6
      QuantiTect SYBR Green Assays in human, mouse, rat KCTD6
      QuantiFast Probe-based Assays in human, mouse, rat KCTD6

    Additional mRNA sequence: 

    AK027572.1 AK074934.1 AK075297.1 BC022893.1 

    5 DOTS entries:

    DT.97839288  DT.85100031  DT.100757704  DT.100777561  DT.100839030 

    Selected AceView cDNA sequences (see all 58):

    AA721100 BF724718 AK027572 BG032976 BQ638023 CR613146 AA778205 AA315333 
    AI192865 AW149852 BM975161 AA682546 BQ186231 BF691629 AA702885 BX383728 
    CB157922 AA649271 AA286692 BX095242 BG113742 NM_153331 AK075297 AK074934 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCTD6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KCTD6 Expression
    About this image


    KCTD6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Thalamus
    KCTD6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCTD6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.13982
        Custom PCR Arrays for KCTD6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KCTD6
    OriGene qSTAR qPCR primer pairs in human, mouse for KCTD6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCTD6
    QuantiTect SYBR Green Assays in human, mouse, rat KCTD6
    QuantiFast Probe-based Assays in human, mouse, rat KCTD6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KCTD6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kctd61 , 5 potassium channel tetramerisation domain containing more1, 5 88.75(n)1
    99.16(a)1
      14 (4.76 cM)5
    713931  NM_027782.21  NP_082058.11 
     82141485 
    chicken
    (Gallus gallus)
    Aves KCTD61 potassium channel tetramerisation domain containing more 82.98(n)
    97.89(a)
      416067  XM_414405.4  XP_414405.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCTD66
    potassium channel tetramerization domain containin...
    97(a)
    1 ↔ 1
    2(187183366-187211940)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kctd61 potassium channel tetramerization domain containing more 80.31(n)
    94.94(a)
      100216157  NM_001142128.1  NP_001135600.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.199822 Transcribed sequence with weak similarity to protein more 76.21(n)    CD758726.1 


    ENSEMBL Gene Tree for KCTD6 (if available)
    TreeFam Gene Tree for KCTD6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCTD6 gene
    KCTD12  KCTD82  KCTD152  KCTD162  KCTD42  KCTD112  KCNRG2  KCTD122  
    KCTD212  KCTD142  
    9 SIMAP similar genes for KCTD6 using alignment to 2 protein entries:     KCTD6_HUMAN (see all proteins):
    KCTD21    KCTD15    SHKBP1    KCTD1    TNFAIP1    KCTD10
    KCTD13    KCTD19    KCTD5

    KCTD6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KCTD6
    PGOHUM00000242504


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCTD6 (see all 214)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1400416021,2
    C,Funtested158487256(+) TTTCAC/TGATCC 4 T M mis11Minor allele frequency- T:0.00NA 4548
    rs1428209121,2
    --58475833(+) CACAGC/TGAATT 1 -- us2k10--------
    rs798232101,2
    C--58475888(+) GCTGAA/GTATAA 1 -- us2k10--------
    rs762712241,2
    C--58475889(+) CTGAAG/TATAAG 1 -- us2k10--------
    rs1460632081,2
    --58475938(+) CAATTA/GTAAAA 1 -- us2k10--------
    rs1134417481,2
    F--58475966(+) AATTAG/TCACTA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1146091171,2
    F--58476070(+) AGAGGG/AGAAAT 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1419539821,2
    --58476077(+) AAATGA/TCTCTT 1 -- us2k10--------
    rs1826052551,2
    --58476198(+) AACCCA/TGTGGG 1 -- us2k10--------
    rs98456631,2
    C--58476203(+) AGTGGG/AGTGGG 1 -- us2k1 tfbs33Minor allele frequency- A:0.10WA NA 240

    HapMap Linkage Disequilibrium report for KCTD6 (58477823 - 58488087 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KCTD6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv24287CNV Loss19812545
    nsv876831CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCTD6
    DNA2.0 Custom Variant and Variant Library Synthesis for KCTD6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for KCTD6:    
    About MalaCards
    maturity-onset diabetes of the young    cholera    medulloblastoma    neuronitis
    hepatitis

    1 disease from the University of Copenhagen DISEASES database for KCTD6:
    Hereditary spherocytosis

    KCTD6 for disorders           About GeneDecksing


    Export disorders for KCTD6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCTD6 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with KCTD6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma. (PubMed id 21472142)1, 3 De Smaele E....Gulino A. (Neoplasia 2011)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    6. Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. (PubMed id 22573887)1 Lange S....Chen J. (Mol. Biol. Cell 2012)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    9. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 200845 HGNC: 22235 AceView: KCTD6 Ensembl:ENSG00000168301 euGenes: HUgn200845
    ECgene: KCTD6 H-InvDB: KCTD6

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCTD6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCTD6 gene:
    Search GeneIP for patents involving KCTD6

    GeneCards and IP:
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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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