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Aliases for KCTD6 Gene

Aliases for KCTD6 Gene

  • Potassium Channel Tetramerization Domain Containing 6 2 3 5
  • Potassium Channel Tetramerisation Domain Containing 6 2 3
  • BTB/POZ Domain-Containing Protein KCTD6 3
  • KCASH3 3

External Ids for KCTD6 Gene

Previous GeneCards Identifiers for KCTD6 Gene

  • GC03P058435
  • GC03P058440

Summaries for KCTD6 Gene

GeneCards Summary for KCTD6 Gene

KCTD6 (Potassium Channel Tetramerization Domain Containing 6) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Innate Immune System. GO annotations related to this gene include ankyrin binding. An important paralog of this gene is KCTD21.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD6 Gene

Genomics for KCTD6 Gene

Regulatory Elements for KCTD6 Gene

Enhancers for KCTD6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G058348 2 FANTOM5 Ensembl ENCODE dbSUPER 25.3 -141.5 -141524 3.7 HDGF FEZF1 ZNF2 YY1 ZNF766 CBX5 ZNF143 ZNF416 FOS ZNF263 DENND6A FLNB-AS1 KCTD6 RPP14 PXK FLNB DNASE1L3 ABHD6 PDHB LOC105377106
GH03G058332 1.4 ENCODE dbSUPER 25.3 -157.6 -157637 4.6 HDGF FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF766 CBX5 ZNF416 DENND6A KCTD6 RPP14 FLNB-AS1 HTD2 PXK ABHD6 ACOX2 ENSG00000272182 ENSG00000273493
GH03G058469 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -20.5 -20472 3.4 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 FOS SP3 RPP14 PXK PDHB KCTD6 ACOX2 HTD2 FAM107A ENSG00000243384 ENSG00000272182 ENSG00000272360
GH03G057947 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12 -541.3 -541294 6.6 HDGF FOXA2 PKNOX1 ZFP64 ARID4B SIN3A ZNF766 FOS SP5 ZNF592 FLNB-AS1 FLNB DENND6A KCTD6 APPL1 ABHD6 DNASE1L3 SLMAP PXK GC03P057941
GH03G058462 1.2 Ensembl ENCODE 13 -28.5 -28457 1.6 PKNOX1 FOXA2 ARID4B ZNF207 ZNF143 DEK REST TBX21 KAT8 SMARCA4 PDHB RPP14 PXK KCTD6 ACOX2 HTD2 ENSG00000243384 FAM107A ENSG00000272360
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCTD6 on UCSC Golden Path with GeneCards custom track

Promoters for KCTD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000153241 204 1401 PKNOX1 ARNT DMAP1 ZNF48 GLIS2 ZNF143 DEK SP3 JUNB REST

Genomic Location for KCTD6 Gene

Chromosome:
3
Start:
58,492,096 bp from pter
End:
58,502,360 bp from pter
Size:
10,265 bases
Orientation:
Plus strand

Genomic View for KCTD6 Gene

Genes around KCTD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD6 Gene

Proteins for KCTD6 Gene

  • Protein details for KCTD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NC69-KCTD6_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein KCTD6
    Protein Accession:
    Q8NC69
    Secondary Accessions:
    • B3KNI5
    • Q8NBS6
    • Q8TCA6

    Protein attributes for KCTD6 Gene

    Size:
    237 amino acids
    Molecular mass:
    27610 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KCTD6 Gene

Post-translational modifications for KCTD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD6 Gene

No data available for DME Specific Peptides for KCTD6 Gene

Domains & Families for KCTD6 Gene

Protein Domains for KCTD6 Gene

Suggested Antigen Peptide Sequences for KCTD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KCTD6: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KCTD6 Gene

Function for KCTD6 Gene

Gene Ontology (GO) - Molecular Function for KCTD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0030506 ankyrin binding IDA 22573887
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with KCTD6: view
genes like me logo Genes that share phenotypes with KCTD6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD6 Gene

Localization for KCTD6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD6 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for KCTD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KCTD6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KCTD6 Gene

Pathways & Interactions for KCTD6 Gene

genes like me logo Genes that share pathways with KCTD6: view

Gene Ontology (GO) - Biological Process for KCTD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043687 post-translational protein modification TAS --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD6: view

No data available for SIGNOR curated interactions for KCTD6 Gene

Drugs & Compounds for KCTD6 Gene

No Compound Related Data Available

Transcripts for KCTD6 Gene

Unigene Clusters for KCTD6 Gene

Potassium channel tetramerisation domain containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD6 Gene

No ASD Table

Relevant External Links for KCTD6 Gene

GeneLoc Exon Structure for
KCTD6
ECgene alternative splicing isoforms for
KCTD6

Expression for KCTD6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCTD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KCTD6 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KCTD6 Gene



Protein tissue co-expression partners for KCTD6 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCTD6 Gene:

KCTD6

SOURCE GeneReport for Unigene cluster for KCTD6 Gene:

Hs.13982

Evidence on tissue expression from TISSUES for KCTD6 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with KCTD6: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCTD6 Gene

Orthologs for KCTD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCTD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD6 34 35
  • 100 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KCTD6 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCTD6 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCTD6 34 35
  • 95.22 (n)
cow
(Bos Taurus)
Mammalia KCTD6 34 35
  • 92.97 (n)
rat
(Rattus norvegicus)
Mammalia Kctd6 34
  • 89.03 (n)
mouse
(Mus musculus)
Mammalia Kctd6 34 16 35
  • 88.75 (n)
chicken
(Gallus gallus)
Aves KCTD6 34 35
  • 82.98 (n)
lizard
(Anolis carolinensis)
Reptilia KCTD6 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd6 34
  • 80.31 (n)
zebrafish
(Danio rerio)
Actinopterygii kctd6b 35
  • 90 (a)
OneToMany
kctd6a 34 35
  • 75.39 (n)
Dr.19982 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12176 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
OneToMany
Species where no ortholog for KCTD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCTD6 Gene

ENSEMBL:
Gene Tree for KCTD6 (if available)
TreeFam:
Gene Tree for KCTD6 (if available)

Paralogs for KCTD6 Gene

Paralogs for KCTD6 Gene

(9) SIMAP similar genes for KCTD6 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for KCTD6 Gene

genes like me logo Genes that share paralogs with KCTD6: view

Variants for KCTD6 Gene

Sequence variations from dbSNP and Humsavar for KCTD6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000175041 -- 58,492,811(+) GTGGT(A/G)GAGGC intron-variant, upstream-variant-2KB
rs1000204706 -- 58,492,591(+) GAGAT(C/G)GCGCT intron-variant, upstream-variant-2KB
rs1000244893 -- 58,500,574(+) GCCTT(-/A)AAAAA intron-variant
rs1000331495 -- 58,500,818(+) GCATT(A/T)GAGGA intron-variant
rs1000333753 -- 58,501,545(+) ACCCG(C/G)GTGCA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for KCTD6 Gene

Variant ID Type Subtype PubMed ID
dgv8338n54 CNV loss 21841781
dgv8339n54 CNV gain 21841781
esv24287 CNV loss 19812545
nsv1073225 CNV deletion 25765185
nsv1136364 CNV deletion 24896259
nsv590370 CNV loss 21841781
nsv590371 CNV loss 21841781
nsv590376 CNV loss 21841781
nsv590377 CNV gain+loss 21841781

Variation tolerance for KCTD6 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD6 Gene

Human Gene Mutation Database (HGMD)
KCTD6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCTD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD6 Gene

Disorders for KCTD6 Gene

Relevant External Links for KCTD6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCTD6

No disorders were found for KCTD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD6 Gene

Publications for KCTD6 Gene

  1. Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma. (PMID: 21472142) De Smaele E. … Gulino A. (Neoplasia 2011) 2 3 64
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Structural Insights into KCTD Protein Assembly and Cullin3 Recognition. (PMID: 26334369) Ji A.X. … PrivAc G.G. (J. Mol. Biol. 2016) 3 64

Products for KCTD6 Gene

Sources for KCTD6 Gene

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