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Aliases for KCTD6 Gene

Aliases for KCTD6 Gene

  • Potassium Channel Tetramerization Domain Containing 6 2 3 5
  • Potassium Channel Tetramerisation Domain Containing 6 2 3
  • KCASH3 3

External Ids for KCTD6 Gene

Previous GeneCards Identifiers for KCTD6 Gene

  • GC03P058435
  • GC03P058440

Summaries for KCTD6 Gene

GeneCards Summary for KCTD6 Gene

KCTD6 (Potassium Channel Tetramerization Domain Containing 6) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. GO annotations related to this gene include ankyrin binding. An important paralog of this gene is KCTD11.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD6 Gene

Genomics for KCTD6 Gene

Regulatory Elements for KCTD6 Gene

Enhancers for KCTD6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCTD6 on UCSC Golden Path with GeneCards custom track

Promoters for KCTD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KCTD6 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCTD6 Gene

58,492,096 bp from pter
58,502,360 bp from pter
10,265 bases
Plus strand

Genomic View for KCTD6 Gene

Genes around KCTD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD6 Gene

Proteins for KCTD6 Gene

  • Protein details for KCTD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD6
    Protein Accession:
    Secondary Accessions:
    • B3KNI5
    • Q8NBS6
    • Q8TCA6

    Protein attributes for KCTD6 Gene

    237 amino acids
    Molecular mass:
    27610 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KCTD6 Gene

Proteomics data for KCTD6 Gene at MOPED

Post-translational modifications for KCTD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD6 Gene

No data available for DME Specific Peptides for KCTD6 Gene

Domains & Families for KCTD6 Gene

Protein Domains for KCTD6 Gene

Suggested Antigen Peptide Sequences for KCTD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD6: view

No data available for Gene Families for KCTD6 Gene

Function for KCTD6 Gene

Gene Ontology (GO) - Molecular Function for KCTD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KCTD6: view
genes like me logo Genes that share phenotypes with KCTD6: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD6 Gene

Localization for KCTD6 Gene

Subcellular locations from

Jensen Localization Image for KCTD6 Gene COMPARTMENTS Subcellular localization image for KCTD6 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD6 Gene

Pathways & Interactions for KCTD6 Gene

genes like me logo Genes that share pathways with KCTD6: view

Gene Ontology (GO) - Biological Process for KCTD6 Gene


No data available for SIGNOR curated interactions for KCTD6 Gene

Drugs & Compounds for KCTD6 Gene

No Compound Related Data Available

Transcripts for KCTD6 Gene

Unigene Clusters for KCTD6 Gene

Potassium channel tetramerisation domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD6 Gene

No ASD Table

Relevant External Links for KCTD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD6 Gene

mRNA expression in normal human tissues for KCTD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KCTD6 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCTD6 Gene

SOURCE GeneReport for Unigene cluster for KCTD6 Gene Hs.13982

genes like me logo Genes that share expression patterns with KCTD6: view

Protein tissue co-expression partners for KCTD6 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KCTD6 Gene

Orthologs for KCTD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCTD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCTD6 35
  • 92.97 (n)
  • 99.58 (a)
KCTD6 36
  • 100 (a)
(Canis familiaris)
Mammalia KCTD6 35
  • 95.22 (n)
  • 100 (a)
KCTD6 36
  • 92 (a)
(Mus musculus)
Mammalia Kctd6 35
  • 88.75 (n)
  • 99.16 (a)
Kctd6 16
Kctd6 36
  • 99 (a)
(Pan troglodytes)
Mammalia KCTD6 35
  • 100 (n)
  • 100 (a)
KCTD6 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Kctd6 35
  • 89.03 (n)
  • 99.58 (a)
(Monodelphis domestica)
Mammalia KCTD6 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia KCTD6 36
  • 99 (a)
(Gallus gallus)
Aves KCTD6 35
  • 82.98 (n)
  • 97.89 (a)
KCTD6 36
  • 98 (a)
(Anolis carolinensis)
Reptilia KCTD6 36
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd6 35
  • 80.31 (n)
  • 94.94 (a)
(Danio rerio)
Actinopterygii Dr.19982 35
kctd6a 35
  • 75.39 (n)
  • 86.92 (a)
kctd6a 36
  • 87 (a)
kctd6b 36
  • 90 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12176 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for KCTD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCTD6 Gene

Gene Tree for KCTD6 (if available)
Gene Tree for KCTD6 (if available)

Paralogs for KCTD6 Gene

Paralogs for KCTD6 Gene

(9) SIMAP similar genes for KCTD6 Gene using alignment to 2 proteins: Pseudogenes for KCTD6 Gene

genes like me logo Genes that share paralogs with KCTD6: view

Variants for KCTD6 Gene

Sequence variations from dbSNP and Humsavar for KCTD6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs4368517 -- 58,498,261(+) TAGGC(A/G)TGAGC intron-variant, upstream-variant-2KB
rs7625947 -- 58,497,903(+) TGATG(C/T)TTTTA intron-variant, upstream-variant-2KB
rs4681686 -- 58,491,553(+) ATAAC(C/T)TGTCA upstream-variant-2KB
rs4681688 -- 58,496,164(+) AACCC(A/G)TTATG intron-variant
rs7628002 -- 58,494,275(+) TACTT(A/G)TGCTG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for KCTD6 Gene

Variant ID Type Subtype PubMed ID
nsv876831 CNV Gain 21882294
esv24287 CNV Loss 19812545

Variation tolerance for KCTD6 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD6 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD6 Gene

Disorders for KCTD6 Gene

Relevant External Links for KCTD6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KCTD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD6 Gene

Publications for KCTD6 Gene

  1. Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma. (PMID: 21472142) De Smaele E. … Gulino A. (Neoplasia 2011) 2 3 67
  2. Structural Insights into KCTD Protein Assembly and Cullin3 Recognition. (PMID: 26334369) Ji A.X. … PrivAc G.G. (J. Mol. Biol. 2016) 3
  3. Cullin 3 Recognition Is Not a Universal Property among KCTD Proteins. (PMID: 25974686) Smaldone G. … Vitagliano L. (PLoS ONE 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 3

Products for KCTD6 Gene

Sources for KCTD6 Gene