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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KCTD6 Gene

protein-coding GIFtS: 45
GCID: GC03P058452

potassium channel tetramerisation domain containing 6

Explore 3 diseases affiliated with
KCTD6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Potassium Channel Tetramerisation Domain Containing 6¹ ²
KCASH3¹ ²
MGC27385¹
BTB/POZ Domain-Containing Protein KCTD6²

External Ids:	HGNC: 22235¹	Entrez Gene: 200845²	Ensembl: ENSG00000168301⁷	UniProtKB: Q8NC69³

Export aliases for KCTD6 gene to outside databases

Previous GC identifers: GC03P058435 GC03P058440

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KCTD6 gene promoter:
STAT5B AREB6 HNF-1 MyoD aMEF-2 HNF-1A
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for KCTD6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.3 Ensembl cytogenetic band: 3p14.3 HGNC cytogenetic band: 3p21.2

KCTD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCTD6 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P058452: view genomic region (about GC identifiers)

Start:	58,477,823 bp from pter	End:	58,488,087 bp from pter
Size:	10,265 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KCTD6_HUMAN, Q8NC69 (See protein sequence)

Recommended Name: BTB/POZ domain-containing protein KCTD6

Size: 237 amino acids; 27610 Da

Secondary accessions: B3KNI5 Q8NBS6 Q8TCA6

Explore the universe of human proteins at neXtProt for KCTD6: NX_Q8NC69

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NC69

KCTD6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001121686.1 NP_699162.3

ENSEMBL proteins:

ENSP00000384948 ENSP00000417490 ENSP00000442507 ENSP00000418999 ENSP00000347188

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KCTD6 for domains About GeneDecksing

3 InterPro domains/families:

IPR000210 BTB/POZ-like

IPR011333 BTB/POZ_fold

IPR003131 T1-type_BTB

Graphical View of Domain Structure for InterPro Entry Q8NC69

ProtoNet protein and cluster: Q8NC69

UniProtKB/Swiss-Prot: KCTD6_HUMAN, Q8NC69

Similarity: Contains 1 BTB (POZ) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Sweet Taste Signaling

Sweet Taste Signaling	1.00	Bitter Taste Signaling	0.44
Melatonin Signaling	0.72	Sperm Motility	0.36
Cellular Effects of Sildenafil	0.46

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			PKA Signaling	0.56
	cAMP Pathway	0.77

Neuropathic Pain-Signaling in Dorsal Horn Neurons

	Neuropathic Pain-Signaling in Dorsal Horn Neurons	1.00			Cholera Infection	0.40
	Aldosterone Signaling in Epithelial Cells	0.47

Hepatic ABC Transporters

Hepatic ABC Transporters

1.00

MODY (Maturity-Onset Diabetes of Young)

0.41

5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCTD6 (see all 13)

	Cholera Infection
	Neuropathic Pain-Signaling in Dorsal Horn Neurons
	Hepatic ABC Transporters
	PKA Signaling
	Sweet Taste Signaling

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KCTD6

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for KCTD6 (Q8NC69³ ENSP00000347188⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
USP11	P51784³, ENSP00000218348⁴	I2D: score=2 STRING: ENSP00000218348

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0051260	protein homooligomerization	IEA	--

KCTD6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KCTD6
Search CenterWatch for drugs/clinical trials and news about KCTD6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for KCTD6 gene (2 alternative transcripts):

NM_001128214.1 NM_153331.3

Unigene Cluster for KCTD6:

Potassium channel tetramerisation domain containing 6

Hs.13982 [show with all ESTs]

Unigene Representative Sequence: AK027572

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000404589(uc003dkj.4) ENST00000490264 ENST00000491093 ENST00000479179

ENST00000355076(uc003dkk.4) ENST00000479470

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		hsa-miR-140-3p hsa-miR-153 hsa-miR-548v hsa-miR-1911*
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Additional cDNA sequence:

AK027572.1 AK074934.1 AK075297.1 BC022893.1

5 DOTS entries:

DT.97839288 DT.85100031 DT.100757704 DT.100777561 DT.100839030

24/58 AceView cDNA sequences (see all 58):

BF724718 BG032976 AA721100 CR613146 BQ638023 AA315333 AK027572 AI192865

AA778205 AK074934 BX374354 BG537096 BG992471 W80381 BM975161 AK075297

AW149852 CB157922 BQ186231 AA649271 AA702885 AA682546 BG776810 BG701201

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCTD6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

KCTD6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Thalamus

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KCTD6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCTD6

SOURCE GeneReport for Unigene cluster: Hs.13982

SABiosciences Custom PCR Arrays for KCTD6

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KCTD6 gene from 3/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KCTD6¹	potassium channel tetramerisation domain containing more	82.98(n) 97.89(a)		416067 XM_414405.3 XP_414405.1
lizard (Anolis carolinensis)	Reptilia	KCTD6⁶	--	97(a)	1 ↔ 1	2(187183366-187185841)
zebrafish (Danio rerio)	Actinopterygii	Dr.19982²	Transcribed sequence with weak similarity to protein more	76.21(n)		CD758726.1

ENSEMBL Gene Tree for KCTD6 (if available)
TreeFam Gene Tree for KCTD6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KCTD6 gene

KCTD1² KCTD15² KCTD8² KCTD16² KCTD4² KCNRG² KCTD11² KCTD12²

KCTD21² KCTD14²

8 SIMAP similar genes for KCTD6 using alignment to 2 protein entries: KCTD6_HUMAN (see all proteins):

KCTD21 KCTD15 KCTD1 TNFAIP1 KCTD10 KCTD13

KCTD19 KCTD5

KCTD6 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for KCTD6
PGOHUM00000242504

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140041602^1,2	C,F	other	58487256(+)	`TTTCAC/TGATCC`	4	T M	mis¹		1		NA	4548
rs142820912^1,2		--	58475833(+)	`CACAGC/TGAATT`	1	--	us2k¹		0	--	--	--	--
rs79823210^1,2	C	--	58475888(+)	`GCTGAA/GTATAA`	1	--	us2k¹		0	--	--	--	--
rs76271224^1,2	C	--	58475889(+)	`CTGAAG/TATAAG`	1	--	us2k¹		0	--	--	--	--
rs146063208^1,2		--	58475938(+)	`CAATTA/GTAAAA`	1	--	us2k¹		0	--	--	--	--
rs113441748^1,2		--	58475966(+)	`AATTAG/TCACTA`	1	--	us2k¹		1		CSA	2
rs114609117^1,2	F,	--	58476070(+)	`AGAGGG/AGAAAT`	1	--	us2k¹		1		WA	118
rs141953982^1,2		--	58476077(+)	`AAATGA/TCTCTT`	1	--	us2k¹		0	--	--	--	--
rs182605255^1,2		--	58476198(+)	`AACCCA/TGTGGG`	1	--	us2k¹		0	--	--	--	--
rs9845663^1,2	C,	--	58476203(+)	`AGTGGG/AGTGGG`	1	--	us2k¹ tfbs³		3		WA NA	240

HapMap Linkage Disequilibrium report for KCTD6 (58477823 - 58488087 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KCTD6
1 CNV: 68380
1 Indel: 68381

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCTD6

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KCTD6 for disorders About GeneDecksing

3 diseases for KCTD6: About MalaCards

hereditary spherocytosis spherocytosis medulloblastoma

1 disease from the University of Copenhagen DISEASES database for KCTD6:

Hereditary spherocytosis

Export disorders for KCTD6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KCTD6 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with KCTD6)

Utopia: connect your pdf to the dynamic
world of online information

Identification and characterization of KCASH2 and KCA SH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog acti vity in medulloblastoma. (PubMed id 21472142)^{1, 3} De Smaele E....Gulino A. (2011)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Obscurin and KCTD6 regulate cullin-dependent small ank yrin-1 (sAnk1.5) protein turnover. (PubMed id 22573887)¹ Lange S....Chen J. (2012)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)¹ Bennett E.J....Harper J.W. (2010)
Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)¹ Sowa M.E....Harper J.W. (2009)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 200845	HGNC: 22235	AceView: KCTD6	Ensembl:ENSG00000168301	euGenes: HUgn200845
ECgene: KCTD6	H-InvDB: KCTD6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KCTD6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KCTD6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KCTD6 gene:
Search GeneIP for patents involving KCTD6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCTD6		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCTD6
	OriGene Protein Over-expression Lysate for KCTD6		Browse OriGene Fluorogenic Cell Assay Kits
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	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD6		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD6
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
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	OriGene Purified Protein for KCTD6		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCTD6
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCTD6
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD6
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCTD6
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD6
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	GenScript Custom Purified and Recombinant Proteins Services for KCTD6		GenScript cDNA clones with any tag delivered in your preferred vector for KCTD6
	GenScript Custom Assay Services for KCTD6		GenScript Custom Superior Antibodies Services for KCTD6
	GenScript Custom overexpressing Cell Line Services for KCTD6		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD6

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KCTD6 gene at Home site.

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KCTD6 Gene

potassium channel tetramerisation domain containing 6

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KCTD6 Gene

potassium channel tetramerisation domain containing 6

Aliasesfor KCTD6 gene

Summariesfor KCTD6 gene

Genomic Viewsfor KCTD6 gene

Proteinsfor KCTD6 gene

Protein Domains /Familiesfor KCTD6 gene

Functionfor KCTD6 gene

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for KCTD6 gene

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