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Aliases for KCTD6 Gene

Aliases for KCTD6 Gene

  • Potassium Channel Tetramerization Domain Containing 6 2 3 5
  • Potassium Channel Tetramerisation Domain Containing 6 2 3
  • BTB/POZ Domain-Containing Protein KCTD6 3
  • KCASH3 3

External Ids for KCTD6 Gene

Previous GeneCards Identifiers for KCTD6 Gene

  • GC03P058435
  • GC03P058440

Summaries for KCTD6 Gene

GeneCards Summary for KCTD6 Gene

KCTD6 (Potassium Channel Tetramerization Domain Containing 6) is a Protein Coding gene. Among its related pathways are Hepatic ABC Transporters and Sweet Taste Signaling. GO annotations related to this gene include ankyrin binding. An important paralog of this gene is KCTD21.

Additional gene information for KCTD6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD6 Gene

Genomics for KCTD6 Gene

Regulatory Elements for KCTD6 Gene

Enhancers for KCTD6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H058332 1.4 ENCODE dbSUPER 33.9 -157.6 -157637 4.6 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF766 CBX5 ZNF416 ZNF207 DENND6A FLNB-AS1 FLNB KCTD6 RPP14 PDE12 LOC105377110 HTD2 FAM107A PXK
GH03H058469 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -20.5 -20472 3.4 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 FOS SP3 RPP14 PXK PDHB LOC105377110 KCTD6 ACOX2 HTD2 FAM107A ENSG00000243384 ENSG00000272182
GH03H058462 1.2 Ensembl ENCODE 13 -28.5 -28457 1.6 PKNOX1 FOXA2 ARID4B ZNF207 ZNF143 ATF7 RUNX3 DEK ZC3H11A REST PDHB RPP14 PXK KCTD6 ACOX2 HTD2 ENSG00000243384 FAM107A ENSG00000272360
GH03H058325 1.3 Ensembl ENCODE dbSUPER 11.8 -166.7 -166696 1.6 HDAC1 SOX13 IRF2 ZNF121 GATA3 STAT2 ZNF600 NR2F6 GATAD2A STAT1 PXK RPP14 KCTD6 ACOX2 ENSG00000243384 FAM107A ABHD6 ENSG00000273493 DNASE1L3 PIR62243
GH03H058064 1.4 Ensembl ENCODE dbSUPER 10.4 -425.5 -425489 5 ARID4B FEZF1 RAD21 RARA YY1 ZNF23 GATA2 ZSCAN5C SCRT2 THAP11 KCTD6 FLNB RPP14 FLNB-AS1 ARF4 GC03P058010
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCTD6 on UCSC Golden Path with GeneCards custom track

Promoters for KCTD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for KCTD6 Gene

Genomic Locations for KCTD6 Gene
10,265 bases
Plus strand

Genomic View for KCTD6 Gene

Genes around KCTD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD6 Gene

Proteins for KCTD6 Gene

  • Protein details for KCTD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD6
    Protein Accession:
    Secondary Accessions:
    • B3KNI5
    • Q8NBS6
    • Q8TCA6

    Protein attributes for KCTD6 Gene

    237 amino acids
    Molecular mass:
    27610 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KCTD6 Gene

Post-translational modifications for KCTD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD6 Gene

No data available for DME Specific Peptides for KCTD6 Gene

Domains & Families for KCTD6 Gene

Gene Families for KCTD6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KCTD6 Gene

Suggested Antigen Peptide Sequences for KCTD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KCTD6: view

No data available for UniProtKB/Swiss-Prot for KCTD6 Gene

Function for KCTD6 Gene

Phenotypes From GWAS Catalog for KCTD6 Gene

Gene Ontology (GO) - Molecular Function for KCTD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0030506 ankyrin binding IDA 22573887
GO:0042802 identical protein binding IPI 25416956
GO:0097602 cullin family protein binding IDA 21472142
genes like me logo Genes that share ontologies with KCTD6: view
genes like me logo Genes that share phenotypes with KCTD6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD6 Gene

Localization for KCTD6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD6 gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KCTD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KCTD6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KCTD6 Gene

Pathways & Interactions for KCTD6 Gene

genes like me logo Genes that share pathways with KCTD6: view

Gene Ontology (GO) - Biological Process for KCTD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IDA 21472142
GO:0033146 regulation of intracellular estrogen receptor signaling pathway TAS --
GO:0043687 post-translational protein modification TAS --
GO:0045879 negative regulation of smoothened signaling pathway IDA 21472142
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD6: view

No data available for SIGNOR curated interactions for KCTD6 Gene

Drugs & Compounds for KCTD6 Gene

No Compound Related Data Available

Transcripts for KCTD6 Gene

Unigene Clusters for KCTD6 Gene

Potassium channel tetramerisation domain containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD6 Gene

No ASD Table

Relevant External Links for KCTD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCTD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KCTD6 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KCTD6 Gene

Protein tissue co-expression partners for KCTD6 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCTD6 Gene:


SOURCE GeneReport for Unigene cluster for KCTD6 Gene:


Evidence on tissue expression from TISSUES for KCTD6 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with KCTD6: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCTD6 Gene

Orthologs for KCTD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCTD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KCTD6 33 34
  • 100 (n)
(Ornithorhynchus anatinus)
Mammalia KCTD6 34
  • 99 (a)
(Monodelphis domestica)
Mammalia KCTD6 34
  • 98 (a)
(Canis familiaris)
Mammalia KCTD6 33 34
  • 95.22 (n)
(Bos Taurus)
Mammalia KCTD6 33 34
  • 92.97 (n)
(Rattus norvegicus)
Mammalia Kctd6 33
  • 89.03 (n)
(Mus musculus)
Mammalia Kctd6 33 16 34
  • 88.75 (n)
(Gallus gallus)
Aves KCTD6 33 34
  • 82.98 (n)
(Anolis carolinensis)
Reptilia KCTD6 34
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd6 33
  • 80.31 (n)
(Danio rerio)
Actinopterygii kctd6b 34
  • 90 (a)
kctd6a 33 34
  • 75.39 (n)
Dr.19982 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12176 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 26 (a)
Species where no ortholog for KCTD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCTD6 Gene

Gene Tree for KCTD6 (if available)
Gene Tree for KCTD6 (if available)

Paralogs for KCTD6 Gene

(9) SIMAP similar genes for KCTD6 Gene using alignment to 2 proteins: Pseudogenes for KCTD6 Gene

genes like me logo Genes that share paralogs with KCTD6: view

Variants for KCTD6 Gene

Sequence variations from dbSNP and Humsavar for KCTD6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000175041 -- 58,492,811(+) GTGGT(A/G)GAGGC intron-variant, upstream-variant-2KB
rs1000204706 -- 58,492,591(+) GAGAT(C/G)GCGCT intron-variant, upstream-variant-2KB
rs1000244893 -- 58,500,574(+) GCCTT(-/A)AAAAA intron-variant
rs1000331495 -- 58,500,818(+) GCATT(A/T)GAGGA intron-variant
rs1000333753 -- 58,501,545(+) ACCCG(C/G)GTGCA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for KCTD6 Gene

Variant ID Type Subtype PubMed ID
nsv590377 CNV gain+loss 21841781
nsv590376 CNV loss 21841781
nsv590371 CNV loss 21841781
nsv590370 CNV loss 21841781
nsv1136364 CNV deletion 24896259
nsv1073225 CNV deletion 25765185
esv24287 CNV loss 19812545
dgv8339n54 CNV gain 21841781
dgv8338n54 CNV loss 21841781

Variation tolerance for KCTD6 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD6 Gene

Disorders for KCTD6 Gene

Relevant External Links for KCTD6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KCTD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD6 Gene

Publications for KCTD6 Gene

  1. Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma. (PMID: 21472142) De Smaele E … Gulino A (Neoplasia (New York, N.Y.) 2011) 2 3 60
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for KCTD6 Gene

Sources for KCTD6 Gene

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