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Aliases for KCTD5 Gene

Aliases for KCTD5 Gene

  • Potassium Channel Tetramerization Domain Containing 5 2 3
  • Potassium Channel Tetramerisation Domain Containing 5 2

External Ids for KCTD5 Gene

Previous GeneCards Identifiers for KCTD5 Gene

  • GC16P002732
  • GC16P002672

Summaries for KCTD5 Gene

GeneCards Summary for KCTD5 Gene

KCTD5 (Potassium Channel Tetramerization Domain Containing 5) is a Protein Coding gene. Diseases associated with KCTD5 include rectal neoplasm and agoraphobia. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. An important paralog of this gene is KCTD17.

UniProtKB/Swiss-Prot for KCTD5 Gene

  • Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD5 Gene

Genomics for KCTD5 Gene

Regulatory Elements for KCTD5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCTD5 Gene

2,682,475 bp from pter
2,709,030 bp from pter
26,556 bases
Plus strand

Genomic View for KCTD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCTD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD5 Gene

Proteins for KCTD5 Gene

  • Protein details for KCTD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD5
    Protein Accession:
    Secondary Accessions:
    • D3DU96

    Protein attributes for KCTD5 Gene

    234 amino acids
    Molecular mass:
    26093 Da
    Quaternary structure:
    • Homopentamer. Interacts (via C-terminus) with GRASP55/GORASP2. Interacts with CUL3 and with ubiquitinated proteins. Interacts with adeno-associated virus 2 (AAV-2) REP proteins.

    Three dimensional structures from OCA and Proteopedia for KCTD5 Gene

neXtProt entry for KCTD5 Gene

Proteomics data for KCTD5 Gene at MOPED

Post-translational modifications for KCTD5 Gene

  • Ubiquitination at Lys223 and Lys225
  • Modification sites at PhosphoSitePlus

Other Protein References for KCTD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCTD5 Gene

Domains for KCTD5 Gene

Protein Domains for KCTD5 Gene

Suggested Antigen Peptide Sequences for KCTD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9NXV2
  • The BTB (POZ) domain is atypical and mediates the formation of a homopentamer instead of a homotetramer. Homopentamerization is due to the presence of 4 residues in the BTB (POZ) domain: Leu-56, Gly-100, Val-112 and Ala-118.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD5: view

No data available for Gene Families for KCTD5 Gene

Function for KCTD5 Gene

Molecular function for KCTD5 Gene

UniProtKB/Swiss-Prot Function: Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4
UniProtKB/Swiss-Prot Induction: Up-regulated in peripheral blood lymphocytes stimulated through the T-cell receptor.

Gene Ontology (GO) - Molecular Function for KCTD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17239418
GO:0032403 protein complex binding IDA 23209302
genes like me logo Genes that share ontologies with KCTD5: view

Phenotypes for KCTD5 Gene

GenomeRNAi human phenotypes for KCTD5:
genes like me logo Genes that share phenotypes with KCTD5: view

Animal Model Products

CRISPR Products

miRNA for KCTD5 Gene

miRTarBase miRNAs that target KCTD5

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCTD5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KCTD5 Gene

Localization for KCTD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCTD5 Gene

Cytoplasm, cytosol. Nucleus. Note=Predominantly cytoplasmic, translocated to the nucleus upon interaction with Rep proteins.

Subcellular locations from

Jensen Localization Image for KCTD5 Gene COMPARTMENTS Subcellular localization image for KCTD5 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KCTD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol IDA 18573101
genes like me logo Genes that share ontologies with KCTD5: view

Pathways for KCTD5 Gene

genes like me logo Genes that share pathways with KCTD5: view

Gene Ontology (GO) - Biological Process for KCTD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD5: view

Transcripts for KCTD5 Gene

mRNA/cDNA for KCTD5 Gene

Unigene Clusters for KCTD5 Gene

Potassium channel tetramerisation domain containing 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCTD5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP3: - -

Relevant External Links for KCTD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD5 Gene

mRNA expression in normal human tissues for KCTD5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCTD5 Gene

SOURCE GeneReport for Unigene cluster for KCTD5 Gene Hs.61960

genes like me logo Genes that share expressions with KCTD5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KCTD5 Gene

Orthologs for KCTD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KCTD5 36
  • 99 (a)
LOC453840 35
  • 99.33 (n)
  • 99.49 (a)
(Bos Taurus)
Mammalia KCTD5 35
  • 91.31 (n)
  • 96.58 (a)
KCTD5 36
  • 97 (a)
(Canis familiaris)
Mammalia KCTD5 35
  • 92.59 (n)
  • 97.01 (a)
KCTD5 36
  • 97 (a)
(Mus musculus)
Mammalia Kctd5 35
  • 91.45 (n)
  • 96.15 (a)
Kctd5 16
Kctd5 36
  • 96 (a)
(Monodelphis domestica)
Mammalia KCTD5 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia KCTD5 36
  • 85 (a)
(Rattus norvegicus)
Mammalia Kctd5 35
  • 91.74 (n)
  • 95.73 (a)
(Gallus gallus)
Aves KCTD5 35
  • 77.34 (n)
  • 86.4 (a)
KCTD5 36
  • 86 (a)
(Anolis carolinensis)
Reptilia KCTD5 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd5 35
  • 76.7 (n)
  • 92.13 (a)
(Danio rerio)
Actinopterygii kctd5 36
  • 85 (a)
KCTD5 (2 of 2) 36
  • 71 (a)
kctd5a 35
  • 77.83 (n)
  • 90.91 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000083 35
  • 68.07 (n)
  • 68.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta inc 35
  • 65.6 (n)
  • 65.78 (a)
inc 36
  • 60 (a)
(Caenorhabditis elegans)
Secernentea inso-1 36
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8310 36
  • 67 (a)
Species with no ortholog for KCTD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD5 Gene

Gene Tree for KCTD5 (if available)
Gene Tree for KCTD5 (if available)

Paralogs for KCTD5 Gene

Paralogs for KCTD5 Gene

Selected SIMAP similar genes for KCTD5 Gene using alignment to 2 proteins: Pseudogenes for KCTD5 Gene

genes like me logo Genes that share paralogs with KCTD5: view

Variants for KCTD5 Gene

Sequence variations from dbSNP and Humsavar for KCTD5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs11986 -- 2,708,739(-) TTCTA(A/G)AAAGG utr-variant-3-prime
rs732055 -- 2,700,191(-) GCCAG(A/G)TGATG intron-variant
rs732057 -- 2,700,617(-) GGTGA(C/G/T)GTCAC intron-variant
rs732058 -- 2,700,870(-) GCCCC(C/T)GGCCT intron-variant
rs739717 -- 2,702,153(+) GCCCC(A/G)TGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD5 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2545n71 CNV Loss 21882294
nsv905139 CNV Loss 21882294
dgv2570n71 CNV Loss 21882294
nsv905152 CNV Loss 21882294
dgv793e1 CNV Complex 17122850
nsv833123 CNV Gain+Loss 17160897
esv33514 CNV Gain+Loss 17666407
esv29849 CNV Gain+Loss 19812545
nsv827518 CNV Gain 20364138
esv2421848 CNV Duplication 20811451
nsv905157 CNV Gain 21882294
nsv905158 CNV Loss 21882294
nsv457354 CNV Gain 19166990
dgv2572n71 CNV Loss 21882294
nsv905161 CNV Loss 21882294
nsv905162 CNV Gain 21882294
nsv905163 CNV Gain 21882294
nsv905164 CNV Loss 21882294
nsv471073 CNV Loss 18288195
nsv905165 CNV Loss 21882294
nsv9337 CNV Loss 18304495
nsv519596 CNV Loss 19592680
nsv817714 CNV Loss 17921354

Relevant External Links for KCTD5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD5 Gene

Disorders for KCTD5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for KCTD5 Gene including...

Search for KCTD5 Gene in MalaCards »

(2) University of Copenhagen DISEASES for KCTD5 Gene

genes like me logo Genes that share disorders with KCTD5: view

No data available for UniProtKB/Swiss-Prot for KCTD5 Gene

Publications for KCTD5 Gene

  1. KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases. (PMID: 18573101) Bayon Y. … Alonso A. (FEBS J. 2008) 3 4
  2. Pentameric assembly of potassium channel tetramerization domain- containing protein 5. (PMID: 19361449) Dementieva I.S. … Goldstein S.A. (J. Mol. Biol. 2009) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for KCTD5 Gene

Sources for KCTD5 Gene

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