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KCTD4 Gene

protein-coding   GIFtS: 48
GCID: GC13M045766

Potassium Channel Tetramerization Domain Containing 4

(Previous name: potassium channel tetramerisation domain containing 4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Channel Tetramerization Domain Containing 41 2
Potassium Channel Tetramerisation Domain Containing 41 2
bA321C24.32
BTB/POZ Domain-Containing Protein KCTD42

External Ids:    HGNC: 232271   Entrez Gene: 3866182   Ensembl: ENSG000001803327   UniProtKB: Q8WVF53   

Export aliases for KCTD4 gene to outside databases

Previous GC identifers: GC13U900202 GC13M043564 GC13M044664 GC13M026568


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KCTD4 Gene:
KCTD4 (potassium channel tetramerization domain containing 4) is a protein-coding gene. An important paralog of this gene is KCTD1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCTD4 gene promoter:
         STAT5B   STAT1   STAT4   STAT1beta   STAT5A   CUTL1   POU3F2   STAT1alpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCTD4 promoter sequence
   Search Chromatin IP Primers for KCTD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCTD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.12   Ensembl cytogenetic band:  13q14.12   HGNC cytogenetic band: 13q14.12-q14.13

KCTD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCTD4 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M045766:  view genomic region     (about GC identifiers)

Start:
45,766,988 bp from pter      End:
45,775,175 bp from pter
Size:
8,188 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KCTD4_HUMAN, Q8WVF5 (See protein sequence)
Recommended Name: BTB/POZ domain-containing protein KCTD4  
Size: 259 amino acids; 29967 Da
Secondary accessions: Q5W0P9

Explore the universe of human proteins at neXtProt for KCTD4: NX_Q8WVF5

Explore proteomics data for KCTD4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KCTD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_940686.2  
    ENSEMBL proteins: 
     ENSP00000368402   ENSP00000385144  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003131 T1-type_BTB

    Graphical View of Domain Structure for InterPro Entry Q8WVF5

    ProtoNet protein and cluster: Q8WVF5

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: KCTD4_HUMAN, Q8WVF5
    Similarity: Contains 1 BTB (POZ) domain


    Find genes that share domains with KCTD4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with KCTD4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for KCTD4:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KCTD4

    miRNA
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    miRTarBase miRNAs that target KCTD4:
    hsa-mir-132-3p (MIRT021723)

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    hsa-miR-647 hsa-miR-548p hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-744* hsa-miR-374c hsa-miR-582-5p
    SwitchGear 3'UTR luciferase reporter plasmidKCTD4 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1
    extracellular1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCTD4 About    
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37
    Cellular Effects of Sildenafil0.46
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    4Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    MODY (Maturity-Onset Diabetes of Young)0.41

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KCTD4 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCTD4
    Interactions:

        Search GeneGlobe Interaction Network for KCTD4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for KCTD4 (Q8WVF52, 3 ENSP000003684024) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FXR2P511162, 3, ENSP000002501134MINT-66167 I2D: score=4 STRING: ENSP00000250113
    KCTD4Q8WVF52MINT-68312
    PSMA7ENSP000003599104STRING: ENSP00000359910
    PSMA8ENSP000003111214STRING: ENSP00000311121
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051260protein homooligomerization IEA--

    Find genes that share ontologies with KCTD4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KCTD4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCTD4 gene: 
    NM_198404.2  

    Unigene Cluster for KCTD4:

    Potassium channel tetramerisation domain containing 4
    Hs.23406  [show with all ESTs]
    Unigene Representative Sequence: NM_198404
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379108(uc021rjf.1) ENST00000405872(uc001uzx.4)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate KCTD4 (see all 12):
    hsa-miR-647 hsa-miR-548p hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-744* hsa-miR-374c hsa-miR-582-5p
    SwitchGear 3'UTR luciferase reporter plasmidKCTD4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KCTD4
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    Primer
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    OriGene qPCR primer pairs and template standards for KCTD4
    OriGene qSTAR qPCR primer pairs in human, mouse for KCTD4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCTD4
      QuantiTect SYBR Green Assays in human, mouse, rat KCTD4
      QuantiFast Probe-based Assays in human, mouse, rat KCTD4

    Additional mRNA sequence: 

    AK290675.1 BC018063.1 

    1 DOTS entry:

    DT.442516 

    Selected AceView cDNA sequences (see all 28):

    BI488843 H43813 BQ575935 N52767 AA349999 BG701595 AI373052 AV752480 
    N21323 AA349998 NM_198404 H19105 N27977 CB148722 BX104970 BC018063 
    AW953206 R22676 AW057917 H10765 BG720026 BI481005 N57588 H12995 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCTD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGCTTTAA
    KCTD4 Expression
    About this image


    KCTD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Cerebral Cortex
             Olfactory Bulb   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Growth Plate
     
     Hair (Integumentary System)
             Bulge Stem Cells Bulge
    KCTD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCTD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.23406
        Custom PCR Arrays for KCTD4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KCTD4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kctd41 , 5 potassium channel tetramerisation domain containing more1, 5 92.41(n)1
    97.3(a)1
      14 (40.30 cM)5
    675161  NM_026214.31  NP_080490.31 
     759550035 
    chicken
    (Gallus gallus)
    Aves KCTD41 potassium channel tetramerisation domain containing more 81.84(n)
    87.16(a)
      769400  NM_001199326.1  NP_001186255.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCTD46
    potassium channel tetramerization domain containin...
    87(a)
    1 ↔ 1
    GL343395.1(701413-702186)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kctd41 potassium channel tetramerization domain containing more 77.04(n)
    83.66(a)
      100158517  NM_001127954.1  NP_001121426.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kctd41 potassium channel tetramerisation domain containing more 59.27(n)
    56.03(a)
      792402  NM_001002224.2  NP_001002224.1 


    ENSEMBL Gene Tree for KCTD4 (if available)
    TreeFam Gene Tree for KCTD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCTD4 gene
    KCTD12  KCTD82  KCTD152  KCTD162  KCTD112  KCNRG2  KCTD122  KCTD212  
    KCTD62  KCTD142  

    Find genes that share paralogs with KCTD4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for KCTD4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832596CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCTD4
    DNA2.0 Custom Variant and Variant Library Synthesis for KCTD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCTD4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KCTD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    3. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (Nature 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 386618 HGNC: 23227 AceView: KCTD4 Ensembl:ENSG00000180332 euGenes: HUgn386618
    ECgene: KCTD4 H-InvDB: KCTD4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCTD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KCTD4 gene:
    Search GeneIP for patents involving KCTD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

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