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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCTD4 Gene

protein-coding   GIFtS: 44
GCID: GC13M045766

potassium channel tetramerisation domain containing 4
  Search for KCTD4
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCTD4    

Aliases
for KCTD4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Potassium Channel Tetramerisation Domain Containing 41 2
BA321C24.31
BTB/POZ Domain-Containing Protein KCTD42

External Ids:    HGNC: 232271   Entrez Gene: 3866182   Ensembl: ENSG000001803327   UniProtKB: Q8WVF53   

Export aliases for KCTD4 gene to outside databases

Previous GC identifers: GC13U900202 GC13M043564 GC13M044664 GC13M026568


Summaries
for KCTD4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for KCTD4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCTD4 gene promoter:
         STAT5B   STAT1   STAT4   STAT1beta   STAT5A   CUTL1   POU3F2   STAT1alpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCTD4 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCTD4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.12   Ensembl cytogenetic band:  13q14.12   HGNC cytogenetic band: 13q14.12-q14.13

KCTD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCTD4 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M045766:  view genomic region     (about GC identifiers)

Start:
 45,766,988 bp from pter      End:
 45,775,175 bp from pter
Size:
 8,188 bases      Orientation:
 minus strand

Proteins
for KCTD4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCTD4_HUMAN, Q8WVF5 (See protein sequence)
Recommended Name: BTB/POZ domain-containing protein KCTD4  
Size: 259 amino acids; 29967 Da
Secondary accessions: Q5W0P9

Explore the universe of human proteins at neXtProt for KCTD4: NX_Q8WVF5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WVF5

    • KCTD4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_940686.2  
    ENSEMBL proteins: 
     ENSP00000368402   ENSP00000385144  

    Human Recombinant Protein Products: 
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    Uscn Proteins for KCTD4


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    Protein Domains /
    Families
    for KCTD4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCTD4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003131 T1-type_BTB

    Graphical View of Domain Structure for InterPro Entry Q8WVF5

    ProtoNet protein and cluster: Q8WVF5

    1 Blocks protein family: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: KCTD4_HUMAN, Q8WVF5
    Similarity: Contains 1 BTB (POZ) domain


    Function
    for KCTD4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		 OriGene 3'-UTR Clone: KCTD4
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate KCTD4 (see all 12):
    hsa-miR-647 hsa-miR-548p hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-744* hsa-miR-374c hsa-miR-582-5p
    SwitchGear 3'UTR luciferase reporter plasmid: KCTD4 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD4

    2 GenomeRNAi human phenotypes for KCTD4:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a 


    Pathways & Interactions
    for KCTD4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sweet Taste Signaling
    		Sweet Taste Signaling1.00
    		Bitter Taste Signaling0.44
    		Melatonin Signaling0.72
    		Sperm Motility0.36
    		Cellular Effects of Sildenafil0.46
    2Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		PKA Signaling0.56
    		cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    		Neuropathic Pain-Signaling in Dorsal Horn Neurons1.00
    		Cholera Infection0.40
    		Aldosterone Signaling in Epithelial Cells0.47
    4Hepatic ABC Transporters
    		Hepatic ABC Transporters1.00
    		MODY (Maturity-Onset Diabetes of Young)0.41

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCTD4 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCTD4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for KCTD4 (Q8WVF52, 3 ENSP000003684024) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FXR2P511162, 3, ENSP000002501134MINT-66167 I2D: score=4 STRING: ENSP00000250113
    KCTD4Q8WVF52MINT-68312
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051260protein homooligomerization IEA--


    KCTD4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCTD4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KCTD4
    Search CenterWatch for drugs/clinical trials and news about KCTD4 

    Transcripts
    for KCTD4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCTD4 gene: 
    NM_198404.2  

    Unigene Cluster for KCTD4:

    Potassium channel tetramerisation domain containing 4
    Hs.23406  [show with all ESTs]
    Unigene Representative Sequence: NM_198404
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379108(uc021rjf.1) ENST00000405872(uc001uzx.4)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCTD4
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate KCTD4 (see all 12):
    hsa-miR-647 hsa-miR-548p hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-744* hsa-miR-374c hsa-miR-582-5p
    SwitchGear 3'UTR luciferase reporter plasmid: KCTD4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCTD4 (see all 7)
    OriGene shRNA RFP: KCTD4
    OriGene siRNA: KCTD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCTD4
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD4 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD4

    Additional cDNA sequence: 

    AK290675.1 BC018063.1 

    1 DOTS entry:

    DT.442516 

    24/28 AceView cDNA sequences (see all 28):

    BI488843 BQ575935 H43813 BC018063 CB148722 AI373052 AA349998 AV752480 
    BG701595 BX104970 N27977 N21323 H19105 AA349999 N52767 NM_198404 
    R22676 H10765 BG720026 AW953206 AW057917 BI481005 H12995 N57588 

    GeneLoc Exon Structure


    Expression
    for KCTD4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCTD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGGCTTTAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KCTD4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneZeugopod Epiphyseal EndBone
    BoneZeugopod Growth PlateBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KCTD4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCTD4

    SOURCE GeneReport for Unigene cluster: Hs.23406
        SABiosciences Custom PCR Arrays for KCTD4
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD4

    Orthologs
    for KCTD4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for KCTD4 gene from 3/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KCTD41 potassium channel tetramerisation domain containing more 81.71(n)
    87.16(a)    		   769400  NM_001199326.1  NP_001186255.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KCTD46
    --
    		 --
    		 87(a)
    10(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343395.1(701413-702186)
    GL343234.1(1807046-1807556)
    zebrafish
    (Danio rerio)    		 Actinopterygii kctd41 potassium channel tetramerisation domain containing more 59.4(n)
    56.03(a)    		   792402  NM_001002224.2  NP_001002224.1 


    ENSEMBL Gene Tree for KCTD4 (if available)
    TreeFam Gene Tree for KCTD4 (if available) 

    Paralogs
    for KCTD4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCTD4 gene
    KCTD12  KCTD152  KCTD82  KCTD162  KCNRG2  KCTD122  KCTD112  KCTD212  
    KCTD62  KCTD142  

    KCTD4 for paralogs           About GeneDecksing



    Genomic Variants
    for KCTD4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCTD4
    DNA2.0 Custom Variant and Variant Library Synthesis for KCTD4

    Disorders / Diseases
    for KCTD4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for KCTD4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCTD4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KCTD4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    3. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for KCTD4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KCTD4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 386618 HGNC: 23227 AceView: KCTD4 Ensembl:ENSG00000180332 euGenes: HUgn386618
    ECgene: KCTD4 H-InvDB: KCTD4

    Other Databases showing KCTD4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCTD4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCTD4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCTD4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCTD4 gene:
    Search GeneIP for patents involving KCTD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for KCTD4 gene

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    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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