Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KCTD4 Gene

Aliases for KCTD4 Gene

  • Potassium Channel Tetramerization Domain Containing 4 2 3
  • Potassium Channel Tetramerisation Domain Containing 4 2 3
  • BTB/POZ Domain-Containing Protein KCTD4 3
  • BA321C24.3 3

External Ids for KCTD4 Gene

Previous GeneCards Identifiers for KCTD4 Gene

  • GC13U900202
  • GC13M043564
  • GC13M044664
  • GC13M045766
  • GC13M026568

Summaries for KCTD4 Gene

GeneCards Summary for KCTD4 Gene

KCTD4 (Potassium Channel Tetramerization Domain Containing 4) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. An important paralog of this gene is KCTD11.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD4 Gene

Genomics for KCTD4 Gene

Regulatory Elements for KCTD4 Gene

Genomic Location for KCTD4 Gene

45,192,853 bp from pter
45,201,040 bp from pter
8,188 bases
Minus strand

Genomic View for KCTD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCTD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD4 Gene

Proteins for KCTD4 Gene

  • Protein details for KCTD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD4
    Protein Accession:
    Secondary Accessions:
    • Q5W0P9

    Protein attributes for KCTD4 Gene

    259 amino acids
    Molecular mass:
    29967 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KCTD4 Gene

Proteomics data for KCTD4 Gene at MOPED

Post-translational modifications for KCTD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KCTD4 Gene

Domains for KCTD4 Gene

Protein Domains for KCTD4 Gene

Suggested Antigen Peptide Sequences for KCTD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD4: view

No data available for Gene Families for KCTD4 Gene

Function for KCTD4 Gene

Gene Ontology (GO) - Molecular Function for KCTD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KCTD4: view

Phenotypes for KCTD4 Gene

genes like me logo Genes that share phenotypes with KCTD4: view

Animal Model Products

miRNA for KCTD4 Gene

miRTarBase miRNAs that target KCTD4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD4 Gene

Localization for KCTD4 Gene

Subcellular locations from

Jensen Localization Image for KCTD4 Gene COMPARTMENTS Subcellular localization image for KCTD4 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD4 Gene

Pathways for KCTD4 Gene

genes like me logo Genes that share pathways with KCTD4: view

Gene Ontology (GO) - Biological Process for KCTD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD4: view

Transcripts for KCTD4 Gene

mRNA/cDNA for KCTD4 Gene

(28) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCTD4 Gene

Potassium channel tetramerisation domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD4 Gene

No ASD Table

Relevant External Links for KCTD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD4 Gene

mRNA expression in normal human tissues for KCTD4 Gene

mRNA differential expression in normal tissues according to GTEx for KCTD4 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (14.4), Brain - Amygdala (8.6), Brain - Caudate (basal ganglia) (6.8), Brain - Hippocampus (4.0), and Brain - Putamen (basal ganglia) (4.0).

Protein differential expression in normal tissues for KCTD4 Gene

This gene is overexpressed in Frontal cortex (46.4) and Spinal cord (22.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCTD4 Gene

SOURCE GeneReport for Unigene cluster for KCTD4 Gene Hs.23406

genes like me logo Genes that share expressions with KCTD4: view

Expression partners for KCTD4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KCTD4 Gene

Orthologs for KCTD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCTD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCTD4 35
  • 94.34 (n)
  • 98.46 (a)
KCTD4 36
  • 98 (a)
(Canis familiaris)
Mammalia KCTD4 35
  • 97.3 (n)
  • 99.61 (a)
KCTD4 36
  • 100 (a)
(Mus musculus)
Mammalia Kctd4 35
  • 92.41 (n)
  • 97.3 (a)
Kctd4 16
Kctd4 36
  • 97 (a)
(Pan troglodytes)
Mammalia KCTD4 35
  • 99.74 (n)
  • 100 (a)
KCTD4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Kctd4 35
  • 91.12 (n)
  • 96.14 (a)
(Monodelphis domestica)
Mammalia KCTD4 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia KCTD4 36
  • 94 (a)
(Gallus gallus)
Aves KCTD4 35
  • 81.84 (n)
  • 87.16 (a)
KCTD4 36
  • 87 (a)
(Anolis carolinensis)
Reptilia KCTD4 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd4 35
  • 77.04 (n)
  • 83.66 (a)
(Danio rerio)
Actinopterygii kctd4 35
  • 59.27 (n)
  • 56.03 (a)
kctd4 36
  • 55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
Species with no ortholog for KCTD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCTD4 Gene

Gene Tree for KCTD4 (if available)
Gene Tree for KCTD4 (if available)

Paralogs for KCTD4 Gene

Paralogs for KCTD4 Gene

genes like me logo Genes that share paralogs with KCTD4: view

Variants for KCTD4 Gene

Structural Variations from Database of Genomic Variants (DGV) for KCTD4 Gene

Variant ID Type Subtype PubMed ID
nsv832596 CNV Loss 17160897

Relevant External Links for KCTD4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for KCTD4 Gene

Disorders for KCTD4 Gene

No disorders were found for KCTD4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for KCTD4 Gene

Publications for KCTD4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for KCTD4 Gene

Sources for KCTD4 Gene

Back to Top