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Aliases for KCTD4 Gene

Aliases for KCTD4 Gene

  • Potassium Channel Tetramerization Domain Containing 4 2 3 5
  • Potassium Channel Tetramerisation Domain Containing 4 2 3
  • BTB/POZ Domain-Containing Protein KCTD4 3
  • BA321C24.3 3

External Ids for KCTD4 Gene

Previous GeneCards Identifiers for KCTD4 Gene

  • GC13U900202
  • GC13M043564
  • GC13M044664
  • GC13M045766
  • GC13M026568

Summaries for KCTD4 Gene

GeneCards Summary for KCTD4 Gene

KCTD4 (Potassium Channel Tetramerization Domain Containing 4) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Sweet Taste Signaling. An important paralog of this gene is KCTD21.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD4 Gene

Genomics for KCTD4 Gene

Regulatory Elements for KCTD4 Gene

Enhancers for KCTD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G045177 1.5 Ensembl ENCODE dbSUPER 20.4 +32.3 32298 2.8 PKNOX1 FOXA2 FEZF1 ZNF2 GLIS2 FOS REST TSHZ1 ZNF610 GLIS1 KCTD4 GTF2F2 RNU6-69P
GH13G045199 1 FANTOM5 Ensembl dbSUPER 22.2 +11.2 11202 0.2 POLR2A GLIS1 KCTD4 RNU6-69P
GH13G045204 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.5 +3.8 3813 5.4 FEZF1 ZNF2 GLIS2 FOS JUNB REST MAFF GLIS1 WT1 PRDM4 GTF2F2 KCTD4 TPT1 COG3 RNU6-69P
GH13G045218 1.5 Ensembl ENCODE dbSUPER 8.1 -8.4 -8442 2.8 HDGF PKNOX1 FOXA2 FEZF1 YY1 FOS JUNB TSHZ1 TBX21 KAT8 KCTD4 LOC105370190
GH13G045235 1.4 Ensembl ENCODE dbSUPER 6.8 -25.1 -25078 1.3 CBX3 ZSCAN4 INSM2 FEZF1 ZNF366 ZSCAN5C FOS OVOL3 TSHZ1 ZEB2 KCTD4 LOC105370190
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCTD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCTD4 Gene

Chromosome:
13
Start:
45,192,853 bp from pter
End:
45,211,102 bp from pter
Size:
18,250 bases
Orientation:
Minus strand

Genomic View for KCTD4 Gene

Genes around KCTD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD4 Gene

Proteins for KCTD4 Gene

  • Protein details for KCTD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVF5-KCTD4_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein KCTD4
    Protein Accession:
    Q8WVF5
    Secondary Accessions:
    • Q5W0P9

    Protein attributes for KCTD4 Gene

    Size:
    259 amino acids
    Molecular mass:
    29967 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KCTD4 Gene

Post-translational modifications for KCTD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCTD4 Gene

Domains & Families for KCTD4 Gene

Protein Domains for KCTD4 Gene

Suggested Antigen Peptide Sequences for KCTD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KCTD4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KCTD4 Gene

Function for KCTD4 Gene

Gene Ontology (GO) - Molecular Function for KCTD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25910212
genes like me logo Genes that share ontologies with KCTD4: view
genes like me logo Genes that share phenotypes with KCTD4: view

Animal Model Products

CRISPR Products

miRNA for KCTD4 Gene

miRTarBase miRNAs that target KCTD4

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD4 Gene

Localization for KCTD4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD4 gene
Compartment Confidence
cytoskeleton 2
nucleus 2
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD4 Gene

Pathways & Interactions for KCTD4 Gene

genes like me logo Genes that share pathways with KCTD4: view

Gene Ontology (GO) - Biological Process for KCTD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD4: view

No data available for SIGNOR curated interactions for KCTD4 Gene

Drugs & Compounds for KCTD4 Gene

No Compound Related Data Available

Transcripts for KCTD4 Gene

mRNA/cDNA for KCTD4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCTD4 Gene

Potassium channel tetramerisation domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD4 Gene

No ASD Table

Relevant External Links for KCTD4 Gene

GeneLoc Exon Structure for
KCTD4
ECgene alternative splicing isoforms for
KCTD4

Expression for KCTD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCTD4 Gene

mRNA differential expression in normal tissues according to GTEx for KCTD4 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x14.4), Brain - Amygdala (x8.6), Brain - Caudate (basal ganglia) (x6.8), Brain - Hippocampus (x4.0), and Brain - Putamen (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for KCTD4 Gene

This gene is overexpressed in Frontal cortex (46.4) and Spinal cord (22.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KCTD4 Gene



Protein tissue co-expression partners for KCTD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KCTD4 Gene:

KCTD4

SOURCE GeneReport for Unigene cluster for KCTD4 Gene:

Hs.23406

Evidence on tissue expression from TISSUES for KCTD4 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with KCTD4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCTD4 Gene

Orthologs for KCTD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCTD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD4 34 35
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia KCTD4 34 35
  • 97.3 (n)
oppossum
(Monodelphis domestica)
Mammalia KCTD4 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCTD4 34 35
  • 94.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KCTD4 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kctd4 34 16 35
  • 92.41 (n)
rat
(Rattus norvegicus)
Mammalia Kctd4 34
  • 91.12 (n)
chicken
(Gallus gallus)
Aves KCTD4 34 35
  • 81.84 (n)
lizard
(Anolis carolinensis)
Reptilia KCTD4 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd4 34
  • 77.04 (n)
zebrafish
(Danio rerio)
Actinopterygii kctd4 34 35
  • 59.27 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 19 (a)
OneToMany
Species where no ortholog for KCTD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCTD4 Gene

ENSEMBL:
Gene Tree for KCTD4 (if available)
TreeFam:
Gene Tree for KCTD4 (if available)

Paralogs for KCTD4 Gene

Paralogs for KCTD4 Gene

genes like me logo Genes that share paralogs with KCTD4: view

Variants for KCTD4 Gene

Sequence variations from dbSNP and Humsavar for KCTD4 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000462647 -- 45,199,469(+) CTGTG(C/T)TTTAT intron-variant
rs1001075032 -- 45,192,399(+) CATTA(C/G)CTTTA intron-variant
rs1001378215 -- 45,199,502(+) CCTTA(A/C)GTTTT intron-variant
rs1001403268 -- 45,200,379(+) GTGTA(C/T)TGCAA intron-variant
rs1001434546 -- 45,200,176(+) TGTGA(A/G)CTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD4 Gene

Variant ID Type Subtype PubMed ID
nsv832596 CNV loss 17160897

Variation tolerance for KCTD4 Gene

Residual Variation Intolerance Score: 23.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCTD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD4 Gene

Disorders for KCTD4 Gene

Relevant External Links for KCTD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCTD4

No disorders were found for KCTD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD4 Gene

Publications for KCTD4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  3. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N. … Vidal M. (Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for KCTD4 Gene

Sources for KCTD4 Gene

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