Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KCTD4 Gene

Aliases for KCTD4 Gene

  • Potassium Channel Tetramerization Domain Containing 4 2 3 5
  • Potassium Channel Tetramerisation Domain Containing 4 2 3
  • BTB/POZ Domain-Containing Protein KCTD4 3
  • BA321C24.3 3

External Ids for KCTD4 Gene

Previous GeneCards Identifiers for KCTD4 Gene

  • GC13U900202
  • GC13M043564
  • GC13M044664
  • GC13M045766
  • GC13M026568

Summaries for KCTD4 Gene

GeneCards Summary for KCTD4 Gene

KCTD4 (Potassium Channel Tetramerization Domain Containing 4) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling and Hepatic ABC Transporters. An important paralog of this gene is KCTD21.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD4 Gene

Genomics for KCTD4 Gene

Regulatory Elements for KCTD4 Gene

Enhancers for KCTD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around KCTD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCTD4 Gene

45,192,853 bp from pter
45,211,102 bp from pter
18,250 bases
Minus strand

Genomic View for KCTD4 Gene

Genes around KCTD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD4 Gene

Proteins for KCTD4 Gene

  • Protein details for KCTD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD4
    Protein Accession:
    Secondary Accessions:
    • Q5W0P9

    Protein attributes for KCTD4 Gene

    259 amino acids
    Molecular mass:
    29967 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KCTD4 Gene

Post-translational modifications for KCTD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCTD4 Gene

Domains & Families for KCTD4 Gene

Protein Domains for KCTD4 Gene

Suggested Antigen Peptide Sequences for KCTD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD4: view

No data available for Gene Families for KCTD4 Gene

Function for KCTD4 Gene

genes like me logo Genes that share phenotypes with KCTD4: view

Animal Model Products

CRISPR Products

miRNA for KCTD4 Gene

miRTarBase miRNAs that target KCTD4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD4 Gene

Localization for KCTD4 Gene

Subcellular locations from

Jensen Localization Image for KCTD4 Gene COMPARTMENTS Subcellular localization image for KCTD4 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD4 Gene

Pathways & Interactions for KCTD4 Gene

genes like me logo Genes that share pathways with KCTD4: view

Gene Ontology (GO) - Biological Process for KCTD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD4: view

No data available for SIGNOR curated interactions for KCTD4 Gene

Drugs & Compounds for KCTD4 Gene

No Compound Related Data Available

Transcripts for KCTD4 Gene

mRNA/cDNA for KCTD4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCTD4 Gene

Potassium channel tetramerisation domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD4 Gene

No ASD Table

Relevant External Links for KCTD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD4 Gene

mRNA expression in normal human tissues for KCTD4 Gene

mRNA differential expression in normal tissues according to GTEx for KCTD4 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x14.4), Brain - Amygdala (x8.6), Brain - Caudate (basal ganglia) (x6.8), Brain - Hippocampus (x4.0), and Brain - Putamen (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for KCTD4 Gene

This gene is overexpressed in Frontal cortex (46.4) and Spinal cord (22.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KCTD4 Gene

Protein tissue co-expression partners for KCTD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KCTD4 Gene:


SOURCE GeneReport for Unigene cluster for KCTD4 Gene:

genes like me logo Genes that share expression patterns with KCTD4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for KCTD4 Gene

Orthologs for KCTD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCTD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCTD4 34
  • 94.34 (n)
  • 98.46 (a)
KCTD4 35
  • 98 (a)
(Canis familiaris)
Mammalia KCTD4 34
  • 97.3 (n)
  • 99.61 (a)
KCTD4 35
  • 100 (a)
(Mus musculus)
Mammalia Kctd4 34
  • 92.41 (n)
  • 97.3 (a)
Kctd4 16
Kctd4 35
  • 97 (a)
(Pan troglodytes)
Mammalia KCTD4 34
  • 99.74 (n)
  • 100 (a)
KCTD4 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Kctd4 34
  • 91.12 (n)
  • 96.14 (a)
(Monodelphis domestica)
Mammalia KCTD4 35
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia KCTD4 35
  • 94 (a)
(Gallus gallus)
Aves KCTD4 34
  • 81.84 (n)
  • 87.16 (a)
KCTD4 35
  • 87 (a)
(Anolis carolinensis)
Reptilia KCTD4 35
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd4 34
  • 77.04 (n)
  • 83.66 (a)
(Danio rerio)
Actinopterygii kctd4 34
  • 59.27 (n)
  • 56.03 (a)
kctd4 35
  • 55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 19 (a)
Species where no ortholog for KCTD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCTD4 Gene

Gene Tree for KCTD4 (if available)
Gene Tree for KCTD4 (if available)

Paralogs for KCTD4 Gene

Paralogs for KCTD4 Gene

genes like me logo Genes that share paralogs with KCTD4: view

Variants for KCTD4 Gene

Structural Variations from Database of Genomic Variants (DGV) for KCTD4 Gene

Variant ID Type Subtype PubMed ID
nsv832596 CNV loss 17160897

Variation tolerance for KCTD4 Gene

Residual Variation Intolerance Score: 23.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for KCTD4 Gene

Disorders for KCTD4 Gene

Relevant External Links for KCTD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KCTD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD4 Gene

Publications for KCTD4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 65
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 65
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 65
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3 65

Products for KCTD4 Gene

Sources for KCTD4 Gene

Loading form....