KCTD3 Gene

Aliases
for KCTD3 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Previous GC identifers: GC01P212357 GC01P212797 GC01P212129 GC01P213807 GC01P186414

Summaries
for KCTD3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Genomic Views
for KCTD3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000001.10  NT_004487.20  NC_018912.2  

SwitchGear Promoter luciferase reporter plasmid: KCTD3 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCTD3

KCTD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P215740:  view genomic region     (about GC identifiers)

Proteins
for KCTD3 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

Explore the universe of human proteins at neXtProt for KCTD3: NX_Q9Y597

Explore proteomics data for KCTD3 at MOPED

Post-translational modifications: 

KCTD3 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for KCTD3 Browse OriGene Protein Over-expression Lysates OriGene MassSpec for KCTD3 OriGene Custom Protein Services for KCTD3
	GenScript Custom Purified and Recombinant Proteins Services for KCTD3
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for KCTD3
	Search eBioscience for Proteins for KCTD3
	Search GeneTex for Proteins for KCTD3
	antibodies-online proteins for KCTD3
	antibodies-online peptides for KCTD3

KCTD3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for KCTD3
	Novus Biologicals KCTD3 Antibodies
	Abcam antibodies for KCTD3
	Cloud-Clone Corp. Antibodies for KCTD3
	ThermoFisher Antibodies for KCTD3
	antibodies-online antibodies for KCTD3 (17 products)

KCTD3 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for KCTD3
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KCTD3
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for KCTD3 Cloud-Clone Corp. CLIAs for KCTD3
	Search eBioscience for ELISAs for KCTD3
	antibodies-online kits for KCTD3 (4 products)

Domains /
Families
for KCTD3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

ProtoNet protein and cluster: Q9Y597

Find genes that share domains with KCTD3           About GenesLikeMe

Function
for KCTD3 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for KCTD3

miRNA Products:		miRTarBase miRNAs that target KCTD3: hsa-mir-30c-5p (MIRT047831), hsa-mir-181a-5p (MIRT025044)
		Block miRNA regulation of human, mouse, rat KCTD3 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate KCTD3 (see all 16):
		hsa-miR-30c hsa-miR-513a-3p hsa-miR-561 hsa-miR-4255 hsa-miR-29c hsa-miR-29a hsa-miR-1285 hsa-miR-30d
		SwitchGear 3'UTR luciferase reporter plasmid: KCTD3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for KCTD3
		Predesigned siRNA for gene silencing in human, mouse, rat KCTD3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for KCTD3

Clone Products:		OriGene clones in human, mouse for KCTD3 (see all 7) OriGene ORF clones in mouse, rat for KCTD3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KCTD3 (NM_016121)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCTD3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KCTD3
		Browse ESI BIO Cell Lines and PureStem Progenitors for KCTD3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD3

Localization
for KCTD3 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Pathways & Interactions
for KCTD3 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for KCTD3 About     See pathways by source

Powered by

	SuperPath	Contained pathways About
1	Sweet Taste Signaling	Sweet Taste Signaling 0.72 Bitter Taste Signaling 0.44 Melatonin Signaling 0.72 Sperm Motility 0.37 Cellular Effects of Sildenafil 0.46
2	Activation of cAMP-Dependent PKA	Activation of cAMP-Dependent PKA 0.77 PKA Signaling 0.56 cAMP Pathway 0.77
3	Neuropathic Pain-Signaling in Dorsal Horn Neurons	Neuropathic Pain-Signaling in Dorsal Horn Neurons 0.47 Cholera Infection 0.40 Aldosterone Signaling in Epithelial Cells 0.47
4	Hepatic ABC Transporters	MODY (Maturity-Onset Diabetes of Young) 0.41 Hepatic ABC Transporters 0.41

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KCTD3

	Cholera Infection
	Neuropathic Pain-Signaling in Dorsal Horn Neurons
	Hepatic ABC Transporters
	PKA Signaling
	Sweet Taste Signaling

Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for KCTD3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Transcripts
for KCTD3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

Expression
for KCTD3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCTD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATAATTAAAT

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for KCTD3
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCTD3
		QuantiTect SYBR Green Assays in human, mouse, rat KCTD3
		QuantiFast Probe-based Assays in human, mouse, rat KCTD3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD3

Orthologs
for KCTD3 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

Paralogs
for KCTD3 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for KCTD3 gene

SHKBP1²  

3 SIMAP similar genes for KCTD3 using alignment to 4 protein entries:     KCTD3_HUMAN (see all proteins):

SHKBP1    KCTD17    OK/SW-cl.18

Find genes that share paralogs with KCTD3           About GenesLikeMe

Genomic Variants
for KCTD3 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for KCTD3 (see all 1024)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs120716781,2	C,F,H	--	215738770(+)	TATCTC/TTATAT	1	--	us2k1		9		NS EA NA	1132
rs1379409591,2	C	--	215738839(+)	CCTTC-/TCTTGA	1	--	us2k1		0	--	--	--	--
rs1497120421,2	C	--	215738871(+)	AAGTAC/TAGTAT	1	--	us2k1		0	--	--	--	--
rs570568661,2	C,F	--	215739271(+)	TTCAGC/TTCATC	1	--	us2k1		2		WA	120
rs1129841341,2	F	--	215739299(+)	GTGTAT/CTTTAT	1	--	us2k1		2		CSA WA	119
rs1916826241,2		--	215739364(+)	GACACC/TCTGGT	1	--	us2k1		0	--	--	--	--
rs1836064931,2		--	215739525(+)	GCTACC/GTATGT	1	--	us2k1		0	--	--	--	--
rs120586731,2	C,F,H	--	215739580(+)	TTTTTT/AAAAAA	1	--	us2k1 trp3		7		NS EA WA NA	656
rs768078471,2	C,F	--	215739603(+)	TAGTTG/ATGACG	1	--	us2k1		1		WA	118
rs1455136651,2		--	215739607(+)	TGTGAA/CGAAGA	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for KCTD3 (215740735 - 215795149 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for KCTD3: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing KCTD3

DNA2.0 Custom Variant and Variant Library Synthesis for KCTD3

Disorders / Diseases
for KCTD3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

Publications
for KCTD3 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

1. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)^{1, 2, 3} Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (Nature 2006)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
4. Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3). (PubMed id 23382386)¹ Cao-Ehlker X....Biel M. (J. Biol. Chem. 2013)
5. A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
6. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)¹ Stehling O.... Lill R. (Science 2012)
7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (amp 2011)
9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (Mol. Cell 2011)
10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (amp 2011)

External Searches for KCTD3 gene

Genome Databases showing KCTD3 gene

Other Databases showing KCTD3 gene

Specialized Databases showing KCTD3 gene

Products
for KCTD3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section