Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneAnalytics
- GeneLoc
- GenesLikeMe
- VarElect
- PathCards
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

KCTD3 Gene

protein-coding GIFtS: 52
GCID: GC01P215740

Potassium Channel Tetramerization Domain Containing 3

(Previous name: potassium channel tetramerisation domain containing 3)

Try our

MalaCards

disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
Potassium Channel Tetramerization Domain Containing 3¹ ²
Potassium Channel Tetramerisation Domain Containing 3¹ ²
Renal Carcinoma Antigen NY-REN-45² ³
NY-REN-45²
BTB/POZ Domain-Containing Protein KCTD3²
NY-REN-45 Antigen²

External Ids:	HGNC: 21305¹	Entrez Gene: 51133²	Ensembl: ENSG00000136636⁷	OMIM: 613272⁵	UniProtKB: Q9Y597³

Export aliases for KCTD3 gene to outside databases

Previous GC identifers: GC01P212357 GC01P212797 GC01P212129 GC01P213807 GC01P186414

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for KCTD3 Gene:

KCTD3 (potassium channel tetramerization domain containing 3) is a protein-coding gene. An important paralog of this gene is SHKBP1.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence at NCBI GenBank:

NC_000001.10 NT_004487.20 NC_018912.2

Regulatory elements:

Regulatory transcription factor binding sites in the KCTD3 gene promoter:
HFH-3 CUTL1 YY1 E47 FOXI1 AREB6 MZF-1 Max Hand1 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCTD3 promoter sequence

Search Chromatin IP Primers for KCTD3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCTD3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41 Ensembl cytogenetic band: 1q41 HGNC cytogenetic band: 1q41

KCTD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCTD3 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P215740: view genomic region (about GC identifiers)

Start:	215,740,735 bp from pter	End:	215,795,149 bp from pter
Size:	54,415 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KCTD3_HUMAN, Q9Y597 (See protein sequence)

Recommended Name: BTB/POZ domain-containing protein KCTD3

Size: 815 amino acids; 88984 Da

Miscellaneous: Reacts with sera from 5-25 per cent of cancer patients but not with sera from normal donors.

Seventy per cent of renal cancer patients have antibodies against one or a panel of these antigens

Sequence caution: Sequence=AAH13868.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential

poly-A sequence;

Secondary accessions: A0AV15 D3DTA6 Q49AG7 Q504Q9 Q6PJN6 Q8ND58 Q8NDJ0 Q8WX16

Alternative splicing: 3 isoforms: Q9Y597-1 Q9Y597-2 Q9Y597-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KCTD3: NX_Q9Y597

Explore proteomics data for KCTD3 at MOPED

Post-translational modifications:

Ubiquitination² at Lys426, Lys503, Lys510

Modification sites at PhosphoSitePlus

See KCTD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_057205.2

ENSEMBL proteins:

ENSP00000259154 ENSP00000396726 ENSP00000399962

KCTD3 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for KCTD3 Browse OriGene Protein Over-expression Lysates OriGene MassSpec for KCTD3 OriGene Custom Protein Services for KCTD3
	GenScript Custom Purified and Recombinant Proteins Services for KCTD3
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for KCTD3
	Search eBioscience for Proteins for KCTD3
	antibodies-online proteins for KCTD3
	antibodies-online peptides for KCTD3

KCTD3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for KCTD3
	Novus Biologicals KCTD3 Antibodies
	Abcam antibodies for KCTD3
	Cloud-Clone Corp. Antibodies for KCTD3
	ThermoFisher Antibodies for KCTD3
	antibodies-online antibodies for KCTD3 (17 products)

KCTD3 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for KCTD3
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KCTD3
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for KCTD3 Cloud-Clone Corp. CLIAs for KCTD3
	Search eBioscience for ELISAs for KCTD3
	antibodies-online kits for KCTD3 (4 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

Selected InterPro protein domains (see all 7):

IPR019775 WD40_repeat_CS

IPR000210 BTB/POZ-like

IPR011333 BTB/POZ_fold

IPR001680 WD40_repeat

IPR003131 T1-type_BTB

Graphical View of Domain Structure for InterPro Entry Q9Y597

ProtoNet protein and cluster: Q9Y597

1 Blocks protein domain: IPB000210 BTB/POZ domain

UniProtKB/Swiss-Prot: KCTD3_HUMAN, Q9Y597

Similarity: Belongs to the KCTD3 family

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 5 WD repeats

Find genes that share domains with KCTD3 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

Find genes that share ontologies with KCTD3 About GenesLikeMe

Phenotypes:
3 GenomeRNAi human phenotypes for KCTD3:

Increased cell death HMECs cel

Synthetic lethal with Ras

Synthetic lethal with c-Myc af

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for KCTD3

miRNA Products:		miRTarBase miRNAs that target KCTD3: hsa-mir-30c-5p (MIRT047831), hsa-mir-181a-5p (MIRT025044)

		Block miRNA regulation of human, mouse, rat KCTD3 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate KCTD3 (see all 16):
		hsa-miR-30c hsa-miR-513a-3p hsa-miR-561 hsa-miR-4255 hsa-miR-29c hsa-miR-29a hsa-miR-1285 hsa-miR-30d

		SwitchGear 3'UTR luciferase reporter plasmid: KCTD3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for KCTD3
		Predesigned siRNA for gene silencing in human, mouse, rat KCTD3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for KCTD3

Clone Products:		OriGene clones in human, mouse for KCTD3 (see all 7) OriGene ORF clones in mouse, rat for KCTD3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KCTD3 (NM_016121)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCTD3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KCTD3
		Browse ESI BIO Cell Lines and PureStem Progenitors for KCTD3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD3

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	2
endoplasmic reticulum	1
mitochondrion	1
nucleus	1
peroxisome	1
plasma membrane	1

About this image

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for KCTD3 About

See pathways by source

Powered
by

SuperPath

Contained pathways About

Sweet Taste Signaling

Sweet Taste Signaling	0.72	Bitter Taste Signaling	0.44
Melatonin Signaling	0.72	Sperm Motility	0.37
Cellular Effects of Sildenafil	0.46

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	0.77			PKA Signaling	0.56
	cAMP Pathway	0.77

Neuropathic Pain-Signaling in Dorsal Horn Neurons

	Neuropathic Pain-Signaling in Dorsal Horn Neurons	0.47			Cholera Infection	0.40
	Aldosterone Signaling in Epithelial Cells	0.47

Hepatic ABC Transporters

MODY (Maturity-Onset Diabetes of Young)

0.41

Hepatic ABC Transporters

0.41

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KCTD3 (see all 13)

	Cholera Infection
	Neuropathic Pain-Signaling in Dorsal Horn Neurons
	Hepatic ABC Transporters
	PKA Signaling
	Sweet Taste Signaling

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for KCTD3
Interactions:

Search GeneGlobe Interaction Network for KCTD3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for KCTD3 (Q9Y597³ ENSP00000259154⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 45)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
USP13	Q92995³, ENSP00000263966⁴	I2D: score=2 STRING: ENSP00000263966
LSM8	O95777³, ENSP00000249299⁴	I2D: score=4 STRING: ENSP00000249299
COPS6	Q7L5N1³, ENSP00000304102⁴	I2D: score=2 STRING: ENSP00000304102
SRC	P12931³, ENSP00000350941⁴	I2D: score=1 STRING: ENSP00000350941
ARRB1	P49407³	I2D: score=1

About this table

Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0051260	protein homooligomerization	IEA	--

Find genes that share ontologies with KCTD3 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for KCTD3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for KCTD3 gene:

NM_016121.3

Unigene Cluster for KCTD3:

Potassium channel tetramerisation domain containing 3

Hs.335139 [show with all ESTs]

Unigene Representative Sequence: NM_016121

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000259154(uc001hks.3 uc001hkt.3 uc010pub.2 uc009xdn.3)

ENST00000448333 ENST00000452413 ENST00000495537 ENST00000465650

miRNA Products:		Block miRNA regulation of human, mouse, rat KCTD3 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate KCTD3 (see all 16):
		hsa-miR-30c hsa-miR-513a-3p hsa-miR-561 hsa-miR-4255 hsa-miR-29c hsa-miR-29a hsa-miR-1285 hsa-miR-30d

		SwitchGear 3'UTR luciferase reporter plasmid: KCTD3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for KCTD3
		Predesigned siRNA for gene silencing in human, mouse, rat KCTD3

Clone Products:		OriGene clones in human, mouse for KCTD3 (see all 7) OriGene ORF clones in mouse, rat for KCTD3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KCTD3 (NM_016121)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCTD3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD3

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for KCTD3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat KCTD3
		QuantiTect SYBR Green Assays in human, mouse, rat KCTD3
		QuantiFast Probe-based Assays in human, mouse, rat KCTD3

Additional mRNA sequence:

AK024547.1 AK055925.1 AK296275.1 AK316272.1 AL833887.1 AL834389.1 BC013868.2 BC037896.1

BC094879.1 BC117188.1 BC126173.1 BC143963.1

14 DOTS entries:

DT.91796413 DT.317738 DT.100736505 DT.100783212 DT.121362101 DT.91716350 DT.91835002 DT.121362088

DT.121362105 DT.121362114 DT.121362115 DT.91754867 DT.99982990 DT.86839129

Selected AceView cDNA sequences (see all 227):

AA974718 AI269324 AI394692 NM_016121 AA858164 AI560609 AW779977 W81099

BX389664 CB215094 W93028 CR614111 CA941810 AW195137 T31790 CR618107

AL834389 N58984 CB141271 CA843281 AA480197 BM995609 BE350690 AI824443

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for KCTD3 (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14a	·	14b	·	14c	^	15	^	16a	·	16b	^	17	^	18a	·	18b	·
SP1:																							-																				-
SP2:																							-																				-
SP3:																							-														-		-				-
SP4:																							-		-
SP5:

ExUns:	18c	·	18d
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for KCTD3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

KCTD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATAATTAAAT

About this image

KCTD3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

KCTD3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.335139

UniProtKB/Swiss-Prot: KCTD3_HUMAN, Q9Y597

Tissue specificity: Broadly expressed in normal tissues

Custom PCR Arrays for KCTD3

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for KCTD3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat KCTD3
		QuantiTect SYBR Green Assays in human, mouse, rat KCTD3
		QuantiFast Probe-based Assays in human, mouse, rat KCTD3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for KCTD3 gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Kctd3^{1 , 5}	potassium channel tetramerisation domain containing more^{1, 5}	83.91(n)¹ 93.73(a)¹		1 (93.51 cM)⁵ 226823¹ NM_172650.2¹ NP_766238.1¹ 188971098⁵
chicken (Gallus gallus)	Aves	KCTD3¹	potassium channel tetramerisation domain containing more	78.18(n) 86.63(a)		421359 XM_004935319.1 XP_004935376.1
lizard (Anolis carolinensis)	Reptilia	KCTD3⁶	potassium channel tetramerization domain containin...	86(a)	1 ↔ 1	1(240524171-240580811)
tropical clawed frog (Xenopus tropicalis)	Amphibia	kctd3¹	potassium channel tetramerisation domain containing more	74.12(n) 83.59(a)		100487520 XM_002939274.2 XP_002939320.2
zebrafish (Danio rerio)	Actinopterygii	kctd3¹	potassium channel tetramerisation domain containing more	68.58(n) 76.78(a)		569113 XM_692476.6 XP_697568.4
fruit fly (Drosophila melanogaster)	Insecta	CG9467¹	CG9467	55.54(n) 60.34(a)		41207 NM_141695.3 NP_649952.1
worm (Caenorhabditis elegans)	Secernentea	T23B12.6¹	T23B12.6	55.33(n) 51.78(a)		179226 NM_072776.5 NP_505177.1

ENSEMBL Gene Tree for KCTD3 (if available)
TreeFam Gene Tree for KCTD3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for KCTD3 gene

SHKBP1²

3 SIMAP similar genes for KCTD3 using alignment to 4 protein entries: KCTD3_HUMAN (see all proteins):

SHKBP1 KCTD17 OK/SW-cl.18

Find genes that share paralogs with KCTD3 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12071678^1,2	C,F,H	--	215738770(+)	`TATCTC/TTATAT`	1	--	us2k¹		9		NS EA NA	1132
rs137940959^1,2	C	--	215738839(+)	`CCTTC-/TCTTGA`	1	--	us2k¹		0	--	--	--	--
rs149712042^1,2	C	--	215738871(+)	`AAGTAC/TAGTAT`	1	--	us2k¹		0	--	--	--	--
rs57056866^1,2	C,F	--	215739271(+)	`TTCAGC/TTCATC`	1	--	us2k¹		2		WA	120
rs112984134^1,2	F	--	215739299(+)	`GTGTAT/CTTTAT`	1	--	us2k¹		2		CSA WA	119
rs191682624^1,2		--	215739364(+)	`GACACC/TCTGGT`	1	--	us2k¹		0	--	--	--	--
rs183606493^1,2		--	215739525(+)	`GCTACC/GTATGT`	1	--	us2k¹		0	--	--	--	--
rs12058673^1,2	C,F,H	--	215739580(+)	`TTTTTT/AAAAAA`	1	--	us2k¹ trp³		7		NS EA WA NA	656
rs76807847^1,2	C,F	--	215739603(+)	`TAGTTG/ATGACG`	1	--	us2k¹		1		WA	118
rs145513665^1,2		--	215739607(+)	`TGTGAA/CGAAGA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KCTD3 (215740735 - 215795149 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for KCTD3: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing KCTD3

DNA2.0 Custom Variant and Variant Library Synthesis for KCTD3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 613272 OMIM disorders: --

1 inferred disease relationship from the University of Copenhagen DISEASES database for KCTD3:

Gilles de la Tourette syndrome

Find genes that share disorders with KCTD3 About GenesLikeMe

Export disorders for KCTD3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for KCTD3 gene, integrated from 10 sources (see all 22):
(articles sorted by number of sources associating them with KCTD3)

Utopia: connect your pdf to the dynamic
world of online information

Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)^{1, 2, 3} Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (Nature 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3). (PubMed id 23382386)¹ Cao-Ehlker X....Biel M. (J. Biol. Chem. 2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)¹ Stehling O.... Lill R. (Science 2012)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (amp 2011)
Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (Mol. Cell 2011)
Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (amp 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 51133	HGNC: 21305	AceView: KCTD3	Ensembl:ENSG00000136636	euGenes: HUgn51133
ECgene: KCTD3	H-InvDB: KCTD3

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for KCTD3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for KCTD3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for KCTD3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for KCTD3 gene:
Search GeneIP for patents involving KCTD3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for KCTD3
	Browse OriGene qPCR primer pairs and template standards		Browse OriGene Protein Over-expression Lysates
	OriGene MassSpec for KCTD3		OriGene clones in human, mouse for KCTD3
	OriGene qSTAR qPCR primer pairs in human, mouse for KCTD3		OriGene Purified Protein for KCTD3
	OriGene ORF clones in mouse, rat for KCTD3		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for KCTD3		OriGene Custom Protein Services for KCTD3

	Block miRNA regulation of human, mouse, rat KCTD3 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing KCTD3
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCTD3		Predesigned siRNA for gene silencing in human, mouse, rat KCTD3
	QuantiFast Probe-based Assays in human, mouse, rat KCTD3		QuantiTect SYBR Green Assays in human, mouse, rat KCTD3
	Custom PCR Arrays for KCTD3		Search Chromatin IP Primers for KCTD3
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat KCTD3		Search GeneGlobe Interaction Network for KCTD3
	Regulatory tfbs in KCTD3 promoter

	GenScript Custom Purified and Recombinant Proteins Services for KCTD3		GenScript cDNA clones with any tag delivered in your preferred vector for KCTD3
	GenScript Custom Assay Services for KCTD3		GenScript Custom overexpressing Cell Line Services for KCTD3
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for KCTD3

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	KCTD3 antibodies

	Antibodies for KCTD3
	See all of Abcam's Antibodies, Kits and Proteins for KCTD3
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for KCTD3
	Antibodies for KCTD3
	ELISAs for KCTD3
	CLIAs for KCTD3

Browse ESI BIO Cell Lines and PureStem Progenitors for KCTD3

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD3

	SwitchGear 3'UTR luciferase reporter plasmids for KCTD3
	SwitchGear Promoter luciferase reporter plasmids for KCTD3

ThermoFisher Antibodies for KCTD3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD3

Browse compounds at ApexBio

Search Addgene for plasmids for KCTD3

	Search eBioscience for proteins for KCTD3
	Search eBioscience for elisas for KCTD3
	eBioscience FlowRNA Probe Sets

genOway: Develop your customized and physiologically relevant rodent model for KCTD3

	antibodies-online antibodies for KCTD3 (17 products)
	antibodies-online kits for KCTD3 (4 products)
	antibodies-online peptides for KCTD3
	antibodies-online proteins for KCTD3

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KCTD3 gene at Home site.

Version: 3.12.304 29 Jan 2015
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

KCTD3 Gene

Potassium Channel Tetramerization Domain Containing 3

Aliases
for KCTD3 gene

Summaries
for KCTD3 gene

Genomic Views
for KCTD3 gene

Proteins
for KCTD3 gene

KCTD3 Human Recombinant Protein Products:

KCTD3 Antibody Products:

KCTD3 Assay Products:

Domains /
Families
for KCTD3 gene

Function
for KCTD3 gene

Localization
for KCTD3 gene

Pathways & Interactions
for KCTD3 gene

Drugs & Compounds
for KCTD3 gene

Transcripts
for KCTD3 gene

Expression
for KCTD3 gene

Orthologs
for KCTD3 gene

Paralogs
for KCTD3 gene

Genomic Variants
for KCTD3 gene

Disorders / Diseases
for KCTD3 gene

Publications
for KCTD3 gene

External Searches for KCTD3 gene

Genome Databases showing KCTD3 gene

Other Databases showing KCTD3 gene

Specialized Databases showing KCTD3 gene

Intellectual Property
for KCTD3 gene

Products
for KCTD3 gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

KCTD3 Gene

Potassium Channel Tetramerization Domain Containing 3

Aliasesfor KCTD3 gene

Summariesfor KCTD3 gene

Genomic Viewsfor KCTD3 gene

Proteinsfor KCTD3 gene

KCTD3 Human Recombinant Protein Products:

KCTD3 Antibody Products:

KCTD3 Assay Products:

Domains /Familiesfor KCTD3 gene

Functionfor KCTD3 gene

Localizationfor KCTD3 gene

Pathways & Interactionsfor KCTD3 gene

Drugs & Compoundsfor KCTD3 gene

Transcriptsfor KCTD3 gene

Expression for KCTD3 gene

Orthologsfor KCTD3 gene

Paralogsfor KCTD3 gene

Genomic Variantsfor KCTD3 gene

Disorders / Diseasesfor KCTD3 gene

Publicationsfor KCTD3 gene

External Searches for KCTD3 gene

Genome Databases showing KCTD3 gene

Other Databases showing KCTD3 gene

Specialized Databases showing KCTD3 gene

Intellectual Propertyfor KCTD3 gene

Productsfor KCTD3 gene

View Random Gene

Aliases
for KCTD3 gene

Summaries
for KCTD3 gene

Genomic Views
for KCTD3 gene

Proteins
for KCTD3 gene

Domains /
Families
for KCTD3 gene

Function
for KCTD3 gene

Localization
for KCTD3 gene

Pathways & Interactions
for KCTD3 gene

Drugs & Compounds
for KCTD3 gene

Transcripts
for KCTD3 gene

Expression
for KCTD3 gene

Orthologs
for KCTD3 gene

Paralogs
for KCTD3 gene

Genomic Variants
for KCTD3 gene

Disorders / Diseases
for KCTD3 gene

Publications
for KCTD3 gene

Intellectual Property
for KCTD3 gene

Products
for KCTD3 gene