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KCTD3 Gene

protein-coding   GIFtS: 52
GCID: GC01P215740

Potassium Channel Tetramerization Domain Containing 3

(Previous name: potassium channel tetramerisation domain containing 3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Channel Tetramerization Domain Containing 31 2
Potassium Channel Tetramerisation Domain Containing 31 2
Renal Carcinoma Antigen NY-REN-452 3
NY-REN-452
BTB/POZ Domain-Containing Protein KCTD32
NY-REN-45 Antigen2

External Ids:    HGNC: 213051   Entrez Gene: 511332   Ensembl: ENSG000001366367   OMIM: 6132725   UniProtKB: Q9Y5973   

Export aliases for KCTD3 gene to outside databases

Previous GC identifers: GC01P212357 GC01P212797 GC01P212129 GC01P213807 GC01P186414


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KCTD3 Gene:
KCTD3 (potassium channel tetramerization domain containing 3) is a protein-coding gene. An important paralog of this gene is SHKBP1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCTD3 gene promoter:
         HFH-3   CUTL1   YY1   E47   FOXI1   AREB6   MZF-1   Max   Hand1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCTD3 promoter sequence
   Search Chromatin IP Primers for KCTD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCTD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q41

KCTD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCTD3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P215740:  view genomic region     (about GC identifiers)

Start:
215,740,735 bp from pter      End:
215,795,149 bp from pter
Size:
54,415 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KCTD3_HUMAN, Q9Y597 (See protein sequence)
Recommended Name: BTB/POZ domain-containing protein KCTD3  
Size: 815 amino acids; 88984 Da
Miscellaneous: Reacts with sera from 5-25 per cent of cancer patients but not with sera from normal donors.
Seventy per cent of renal cancer patients have antibodies against one or a panel of these antigens
Sequence caution: Sequence=AAH13868.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: A0AV15 D3DTA6 Q49AG7 Q504Q9 Q6PJN6 Q8ND58 Q8NDJ0 Q8WX16
Alternative splicing: 3 isoforms:  Q9Y597-1   Q9Y597-2   Q9Y597-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KCTD3: NX_Q9Y597

Explore proteomics data for KCTD3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys426, Lys503, Lys510
  • Modification sites at PhosphoSitePlus

  • See KCTD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057205.2  
    ENSEMBL proteins: 
     ENSP00000259154   ENSP00000396726   ENSP00000399962  

    KCTD3 Human Recombinant Protein Products:

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    OriGene Purified Protein for KCTD3
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KCTD3

     
    Search eBioscience for Proteins for KCTD3 

     
    antibodies-online proteins for KCTD3 

     
    antibodies-online peptides for KCTD3

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    Abcam antibodies for KCTD3
    Cloud-Clone Corp. Antibodies for KCTD3
    ThermoFisher Antibodies for KCTD3
    antibodies-online antibodies for KCTD3 (17 products) 

    KCTD3 Assay Products:

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    Cloud-Clone Corp. ELISAs for KCTD3
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    antibodies-online kits for KCTD3 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR019775 WD40_repeat_CS
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR001680 WD40_repeat
     IPR003131 T1-type_BTB

    Graphical View of Domain Structure for InterPro Entry Q9Y597

    ProtoNet protein and cluster: Q9Y597

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: KCTD3_HUMAN, Q9Y597
    Similarity: Belongs to the KCTD3 family
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 5 WD repeats


    Find genes that share domains with KCTD3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with KCTD3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for KCTD3:
     Increased cell death HMECs cel  Synthetic lethal with Ras  Synthetic lethal with c-Myc af 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KCTD3

    miRNA
    Products:
        
    miRTarBase miRNAs that target KCTD3:
    hsa-mir-30c-5p (MIRT047831), hsa-mir-181a-5p (MIRT025044)

    Block miRNA regulation of human, mouse, rat KCTD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCTD3 (see all 16):
    hsa-miR-30c hsa-miR-513a-3p hsa-miR-561 hsa-miR-4255 hsa-miR-29c hsa-miR-29a hsa-miR-1285 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidKCTD3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KCTD3
    Predesigned siRNA for gene silencing in human, mouse, rat KCTD3

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: KCTD3 (NM_016121)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCTD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for KCTD3
    Browse ESI BIO Cell Lines and PureStem Progenitors for KCTD3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCTD3 About    
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37
    Cellular Effects of Sildenafil0.46
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    4Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    MODY (Maturity-Onset Diabetes of Young)0.41

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KCTD3 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCTD3
    Interactions:

        Search GeneGlobe Interaction Network for KCTD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KCTD3 (Q9Y5973 ENSP000002591544) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP13Q929953, ENSP000002639664I2D: score=2 STRING: ENSP00000263966
    LSM8O957773, ENSP000002492994I2D: score=4 STRING: ENSP00000249299
    COPS6Q7L5N13, ENSP000003041024I2D: score=2 STRING: ENSP00000304102
    SRCP129313, ENSP000003509414I2D: score=1 STRING: ENSP00000350941
    ARRB1P494073I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051260protein homooligomerization IEA--

    Find genes that share ontologies with KCTD3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KCTD3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCTD3 gene: 
    NM_016121.3  

    Unigene Cluster for KCTD3:

    Potassium channel tetramerisation domain containing 3
    Hs.335139  [show with all ESTs]
    Unigene Representative Sequence: NM_016121
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259154(uc001hks.3 uc001hkt.3 uc010pub.2 uc009xdn.3)
    ENST00000448333 ENST00000452413 ENST00000495537 ENST00000465650
    miRNA
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    Block miRNA regulation of human, mouse, rat KCTD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCTD3 (see all 16):
    hsa-miR-30c hsa-miR-513a-3p hsa-miR-561 hsa-miR-4255 hsa-miR-29c hsa-miR-29a hsa-miR-1285 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidKCTD3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KCTD3
    Predesigned siRNA for gene silencing in human, mouse, rat KCTD3
    Clone
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    OriGene clones in human, mouse for KCTD3 (see all 7)
    OriGene ORF clones in mouse, rat for KCTD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCTD3 (NM_016121)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCTD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KCTD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCTD3
      QuantiTect SYBR Green Assays in human, mouse, rat KCTD3
      QuantiFast Probe-based Assays in human, mouse, rat KCTD3

    Additional mRNA sequence: 

    AK024547.1 AK055925.1 AK296275.1 AK316272.1 AL833887.1 AL834389.1 BC013868.2 BC037896.1 
    BC094879.1 BC117188.1 BC126173.1 BC143963.1 

    14 DOTS entries:

    DT.91796413  DT.317738  DT.100736505  DT.100783212  DT.121362101  DT.91716350  DT.91835002  DT.121362088 
    DT.121362105  DT.121362114  DT.121362115  DT.91754867  DT.99982990  DT.86839129 

    Selected AceView cDNA sequences (see all 227):

    AA974718 AI269324 AI394692 NM_016121 AA858164 AI560609 AW779977 W81099 
    BX389664 CB215094 W93028 CR614111 CA941810 AW195137 T31790 CR618107 
    AL834389 N58984 CB141271 CA843281 AA480197 BM995609 BE350690 AI824443 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KCTD3 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ·
    SP1:                                                                    -                                                           -                           
    SP2:                                                                    -                                                           -                           
    SP3:                                                                    -                                         -     -           -                           
    SP4:                                                                    -     -                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 18c · 18d
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for KCTD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCTD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAATTAAAT
    KCTD3 Expression
    About this image

    KCTD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCTD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.335139

    UniProtKB/Swiss-Prot: KCTD3_HUMAN, Q9Y597
    Tissue specificity: Broadly expressed in normal tissues

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    QuantiFast Probe-based Assays in human, mouse, rat KCTD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KCTD3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kctd31 , 5 potassium channel tetramerisation domain containing more1, 5 83.91(n)1
    93.73(a)1
      1 (93.51 cM)5
    2268231  NM_172650.21  NP_766238.11 
     1889710985 
    chicken
    (Gallus gallus)
    Aves KCTD31 potassium channel tetramerisation domain containing more 78.18(n)
    86.63(a)
      421359  XM_004935319.1  XP_004935376.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCTD36
    potassium channel tetramerization domain containin...
    86(a)
    1 ↔ 1
    1(240524171-240580811)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kctd31 potassium channel tetramerisation domain containing more 74.12(n)
    83.59(a)
      100487520  XM_002939274.2  XP_002939320.2 
    zebrafish
    (Danio rerio)
    Actinopterygii kctd31 potassium channel tetramerisation domain containing more 68.58(n)
    76.78(a)
      569113  XM_692476.6  XP_697568.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG94671 CG9467 55.54(n)
    60.34(a)
      41207  NM_141695.3  NP_649952.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T23B12.61 T23B12.6 55.33(n)
    51.78(a)
      179226  NM_072776.5  NP_505177.1 


    ENSEMBL Gene Tree for KCTD3 (if available)
    TreeFam Gene Tree for KCTD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCTD3 gene
    SHKBP12  
    3 SIMAP similar genes for KCTD3 using alignment to 4 protein entries:     KCTD3_HUMAN (see all proteins):
    SHKBP1    KCTD17    OK/SW-cl.18

    Find genes that share paralogs with KCTD3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCTD3 (see all 1024)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs120716781,2
    C,F,H--215738770(+) TATCTC/TTATAT 1 -- us2k19Minor allele frequency- T:0.01NS EA NA 1132
    rs1379409591,2
    C--215738839(+) CCTTC-/TCTTGA 1 -- us2k10--------
    rs1497120421,2
    C--215738871(+) AAGTAC/TAGTAT 1 -- us2k10--------
    rs570568661,2
    C,F--215739271(+) TTCAGC/TTCATC 1 -- us2k12Minor allele frequency- T:0.03WA 120
    rs1129841341,2
    F--215739299(+) GTGTAT/CTTTAT 1 -- us2k12Minor allele frequency- C:0.06CSA WA 119
    rs1916826241,2
    --215739364(+) GACACC/TCTGGT 1 -- us2k10--------
    rs1836064931,2
    --215739525(+) GCTACC/GTATGT 1 -- us2k10--------
    rs120586731,2
    C,F,H--215739580(+) TTTTTT/AAAAAA 1 -- us2k1 trp37Minor allele frequency- A:0.16NS EA WA NA 656
    rs768078471,2
    C,F--215739603(+) TAGTTG/ATGACG 1 -- us2k11Minor allele frequency- A:0.23WA 118
    rs1455136651,2
    --215739607(+) TGTGAA/CGAAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCTD3 (215740735 - 215795149 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KCTD3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCTD3
    DNA2.0 Custom Variant and Variant Library Synthesis for KCTD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613272    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for KCTD3:
    Gilles de la Tourette syndrome

    Find genes that share disorders with KCTD3           About GenesLikeMe


    Export disorders for KCTD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCTD3 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with KCTD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2, 3 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3). (PubMed id 23382386)1 Cao-Ehlker X....Biel M. (J. Biol. Chem. 2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51133 HGNC: 21305 AceView: KCTD3 Ensembl:ENSG00000136636 euGenes: HUgn51133
    ECgene: KCTD3 H-InvDB: KCTD3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCTD3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KCTD3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCTD3 gene:
    Search GeneIP for patents involving KCTD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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