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Aliases for KCTD3 Gene

Aliases for KCTD3 Gene

  • Potassium Channel Tetramerization Domain Containing 3 2 3
  • Potassium Channel Tetramerisation Domain Containing 3 2 3
  • Renal Carcinoma Antigen NY-REN-45 3 4
  • NY-REN-45 Antigen 3
  • NY-REN-45 3

External Ids for KCTD3 Gene

Previous GeneCards Identifiers for KCTD3 Gene

  • GC01P212357
  • GC01P212797
  • GC01P212129
  • GC01P213807
  • GC01P215740
  • GC01P186414

Summaries for KCTD3 Gene

GeneCards Summary for KCTD3 Gene

KCTD3 (Potassium Channel Tetramerization Domain Containing 3) is a Protein Coding gene. Diseases associated with KCTD3 include tic disorder. Among its related pathways are Activation of cAMP-Dependent PKA and Neuropathic Pain-Signaling in Dorsal Horn Neurons. An important paralog of this gene is SHKBP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD3 Gene

Genomics for KCTD3 Gene

Regulatory Elements for KCTD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCTD3 Gene

215,567,185 bp from pter
215,621,807 bp from pter
54,623 bases
Plus strand

Genomic View for KCTD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCTD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD3 Gene

Proteins for KCTD3 Gene

  • Protein details for KCTD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD3
    Protein Accession:
    Secondary Accessions:
    • A0AV15
    • D3DTA6
    • Q49AG7
    • Q504Q9
    • Q6PJN6
    • Q8ND58
    • Q8NDJ0
    • Q8WX16

    Protein attributes for KCTD3 Gene

    815 amino acids
    Molecular mass:
    88984 Da
    Quaternary structure:
    No Data Available
    • Reacts with sera from 5-25 per cent of cancer patients but not with sera from normal donors. Seventy per cent of renal cancer patients have antibodies against one or a panel of these antigens
    • Sequence=AAH13868.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for KCTD3 Gene


neXtProt entry for KCTD3 Gene

Proteomics data for KCTD3 Gene at MOPED

Post-translational modifications for KCTD3 Gene

  • Ubiquitination at Lys 503 and Lys 510
  • Modification sites at PhosphoSitePlus

Other Protein References for KCTD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCTD3 Gene

Domains & Families for KCTD3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Belongs to the KCTD3 family.
  • Contains 8 WD repeats.
  • Contains 1 BTB (POZ) domain.
  • Belongs to the KCTD3 family.
  • Contains 8 WD repeats.
genes like me logo Genes that share domains with KCTD3: view

No data available for Gene Families for KCTD3 Gene

Function for KCTD3 Gene

Gene Ontology (GO) - Molecular Function for KCTD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KCTD3: view
genes like me logo Genes that share phenotypes with KCTD3: view

Animal Model Products

miRNA for KCTD3 Gene

miRTarBase miRNAs that target KCTD3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD3 Gene

Localization for KCTD3 Gene

Subcellular locations from

Jensen Localization Image for KCTD3 Gene COMPARTMENTS Subcellular localization image for KCTD3 gene
Compartment Confidence
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD3 Gene

Pathways & Interactions for KCTD3 Gene

genes like me logo Genes that share pathways with KCTD3: view

Gene Ontology (GO) - Biological Process for KCTD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD3: view

No data available for SIGNOR curated interactions for KCTD3 Gene

Drugs & Compounds for KCTD3 Gene

No Compound Related Data Available

Transcripts for KCTD3 Gene

Unigene Clusters for KCTD3 Gene

Potassium channel tetramerisation domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ·
SP1: - -
SP2: - -
SP3: - - - -
SP4: - -

ExUns: 18c · 18d

Relevant External Links for KCTD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD3 Gene

mRNA expression in normal human tissues for KCTD3 Gene

Protein differential expression in normal tissues from HIPED for KCTD3 Gene

This gene is overexpressed in Lung (62.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCTD3 Gene

SOURCE GeneReport for Unigene cluster for KCTD3 Gene Hs.335139

mRNA Expression by UniProt/SwissProt for KCTD3 Gene

Tissue specificity: Broadly expressed in normal tissues.
genes like me logo Genes that share expression patterns with KCTD3: view

Protein tissue co-expression partners for KCTD3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for KCTD3 Gene

Orthologs for KCTD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCTD3 35
  • 91.38 (n)
  • 96.82 (a)
KCTD3 36
  • 96 (a)
(Canis familiaris)
Mammalia KCTD3 35
  • 91.66 (n)
  • 97.2 (a)
KCTD3 36
  • 97 (a)
(Mus musculus)
Mammalia Kctd3 35
  • 83.91 (n)
  • 93.73 (a)
Kctd3 16
Kctd3 36
  • 93 (a)
(Pan troglodytes)
Mammalia KCTD3 35
  • 99.71 (n)
  • 100 (a)
KCTD3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Kctd3 35
  • 83.13 (n)
  • 93.73 (a)
(Monodelphis domestica)
Mammalia KCTD3 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia KCTD3 36
  • 88 (a)
(Gallus gallus)
Aves KCTD3 35
  • 78.18 (n)
  • 86.63 (a)
KCTD3 36
  • 85 (a)
(Anolis carolinensis)
Reptilia KCTD3 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd3 35
  • 74.12 (n)
  • 83.59 (a)
(Danio rerio)
Actinopterygii kctd3 35
  • 68.58 (n)
  • 76.78 (a)
kctd3 36
  • 74 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004087 35
  • 60.2 (n)
  • 68.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9467 35
  • 55.54 (n)
  • 60.34 (a)
CG9467 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea T23B12.6 35
  • 55.33 (n)
  • 51.78 (a)
T23B12.6 36
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
Species with no ortholog for KCTD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD3 Gene

Gene Tree for KCTD3 (if available)
Gene Tree for KCTD3 (if available)

Paralogs for KCTD3 Gene

Paralogs for KCTD3 Gene

(3) SIMAP similar genes for KCTD3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with KCTD3: view

Variants for KCTD3 Gene

Sequence variations from dbSNP and Humsavar for KCTD3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs14137 -- 215,620,492(-) GATGA(C/T)GCCAG synonymous-codon, reference
rs908480 -- 215,590,774(+) TTTGT(C/T)TGCTA intron-variant
rs1074255 -- 215,590,080(-) attag(C/G)atgtg intron-variant
rs1342802 -- 215,606,876(+) TTGAC(A/G)TAATT intron-variant
rs1819739 -- 215,591,054(-) CTACA(C/G)CCTTG intron-variant

Variation tolerance for KCTD3 Gene

Residual Variation Intolerance Score: 8.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.02; 84.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KCTD3 Gene

Disorders for KCTD3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KCTD3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
tic disorder
- elite association
Search KCTD3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KCTD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KCTD3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCTD3 Gene

Publications for KCTD3 Gene

  1. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PMID: 10508479) Scanlan M.J. … Old L.J. (Int. J. Cancer 1999) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3). (PMID: 23382386) Cao-Ehlker X. … Biel M. (J. Biol. Chem. 2013) 67

Products for KCTD3 Gene

Sources for KCTD3 Gene

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