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Aliases for KCTD3 Gene

Aliases for KCTD3 Gene

  • Potassium Channel Tetramerization Domain Containing 3 2 3
  • Potassium Channel Tetramerisation Domain Containing 3 2 3
  • Renal Carcinoma Antigen NY-REN-45 3 4
  • BTB/POZ Domain-Containing Protein KCTD3 3
  • NY-REN-45 Antigen 3
  • NY-REN-45 3

External Ids for KCTD3 Gene

Previous GeneCards Identifiers for KCTD3 Gene

  • GC01P212357
  • GC01P212797
  • GC01P212129
  • GC01P213807
  • GC01P215740
  • GC01P186414

Summaries for KCTD3 Gene

GeneCards Summary for KCTD3 Gene

KCTD3 (Potassium Channel Tetramerization Domain Containing 3) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. An important paralog of this gene is SHKBP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD3 Gene

Genomics for KCTD3 Gene

Regulatory Elements for KCTD3 Gene

Genomic Location for KCTD3 Gene

Start:
215,567,185 bp from pter
End:
215,621,807 bp from pter
Size:
54,623 bases
Orientation:
Plus strand

Genomic View for KCTD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCTD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD3 Gene

Proteins for KCTD3 Gene

  • Protein details for KCTD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y597-KCTD3_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein KCTD3
    Protein Accession:
    Q9Y597
    Secondary Accessions:
    • A0AV15
    • D3DTA6
    • Q49AG7
    • Q504Q9
    • Q6PJN6
    • Q8ND58
    • Q8NDJ0
    • Q8WX16

    Protein attributes for KCTD3 Gene

    Size:
    815 amino acids
    Molecular mass:
    88984 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Reacts with sera from 5-25 per cent of cancer patients but not with sera from normal donors. Seventy per cent of renal cancer patients have antibodies against one or a panel of these antigens
    SequenceCaution:
    • Sequence=AAH13868.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for KCTD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCTD3 Gene

Proteomics data for KCTD3 Gene at MOPED

Post-translational modifications for KCTD3 Gene

  • Ubiquitination at Lys426, Lys503, and Lys510
  • Modification sites at PhosphoSitePlus

Other Protein References for KCTD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCTD3 Gene

Domains for KCTD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y597

UniProtKB/Swiss-Prot:

KCTD3_HUMAN :
  • Q9Y597
Domain:
  • Contains 1 BTB (POZ) domain.
Family:
  • Belongs to the KCTD3 family.
Similarity:
  • Contains 8 WD repeats.
genes like me logo Genes that share domains with KCTD3: view

No data available for Gene Families for KCTD3 Gene

Function for KCTD3 Gene

Gene Ontology (GO) - Molecular Function for KCTD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KCTD3: view
genes like me logo Genes that share phenotypes with KCTD3: view

miRNA for KCTD3 Gene

miRTarBase miRNAs that target KCTD3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KCTD3 Gene

Localization for KCTD3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCTD3 Gene COMPARTMENTS Subcellular localization image for KCTD3 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD3 Gene

Pathways for KCTD3 Gene

genes like me logo Genes that share pathways with KCTD3: view

Gene Ontology (GO) - Biological Process for KCTD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD3: view

Transcripts for KCTD3 Gene

Unigene Clusters for KCTD3 Gene

Potassium channel tetramerisation domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ·
SP1: - -
SP2: - -
SP3: - - - -
SP4: - -
SP5:
SP6:

ExUns: 18c · 18d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for KCTD3 Gene

GeneLoc Exon Structure for
KCTD3
ECgene alternative splicing isoforms for
KCTD3

Expression for KCTD3 Gene

mRNA expression in normal human tissues for KCTD3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCTD3 Gene

SOURCE GeneReport for Unigene cluster for KCTD3 Gene Hs.335139

mRNA Expression by UniProt/SwissProt for KCTD3 Gene

Q9Y597-KCTD3_HUMAN
Tissue specificity: Broadly expressed in normal tissues.
genes like me logo Genes that share expressions with KCTD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for KCTD3 Gene

Orthologs for KCTD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD3 35
  • 99.71 (n)
  • 100 (a)
KCTD3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCTD3 35
  • 91.38 (n)
  • 96.82 (a)
KCTD3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCTD3 35
  • 91.66 (n)
  • 97.2 (a)
KCTD3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kctd3 35
  • 83.91 (n)
  • 93.73 (a)
Kctd3 16
Kctd3 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCTD3 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCTD3 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kctd3 35
  • 83.13 (n)
  • 93.73 (a)
chicken
(Gallus gallus)
Aves KCTD3 35
  • 78.18 (n)
  • 86.63 (a)
KCTD3 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCTD3 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd3 35
  • 74.12 (n)
  • 83.59 (a)
zebrafish
(Danio rerio)
Actinopterygii kctd3 35
  • 68.58 (n)
  • 76.78 (a)
kctd3 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004087 35
  • 60.2 (n)
  • 68.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9467 35
  • 55.54 (n)
  • 60.34 (a)
CG9467 36
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T23B12.6 35
  • 55.33 (n)
  • 51.78 (a)
T23B12.6 36
  • 45 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToMany
Species with no ortholog for KCTD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD3 Gene

ENSEMBL:
Gene Tree for KCTD3 (if available)
TreeFam:
Gene Tree for KCTD3 (if available)

Paralogs for KCTD3 Gene

Paralogs for KCTD3 Gene

Selected SIMAP similar genes for KCTD3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with KCTD3: view

Variants for KCTD3 Gene

Sequence variations from dbSNP and Humsavar for KCTD3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs14137 -- 215,620,492(-) GATGA(C/T)GCCAG synonymous-codon, reference
rs908480 -- 215,590,774(+) TTTGT(C/T)TGCTA intron-variant
rs1074255 -- 215,590,080(-) attag(C/G)atgtg intron-variant
rs1342802 -- 215,606,876(+) TTGAC(A/G)TAATT intron-variant
rs1592231 -- 215,592,218(-) GAGAC(C/T)TAAGT intron-variant

Relevant External Links for KCTD3 Gene

HapMap Linkage Disequilibrium report
KCTD3
Human Gene Mutation Database (HGMD)
KCTD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KCTD3 Gene

Disorders for KCTD3 Gene

(1) University of Copenhagen DISEASES for KCTD3 Gene

genes like me logo Genes that share disorders with KCTD3: view

No data available for UniProtKB/Swiss-Prot for KCTD3 Gene

Publications for KCTD3 Gene

  1. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PMID: 10508479) Scanlan M.J. … Old L.J. (Int. J. Cancer 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PMID: 17620599) Xiao K. … Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3
  5. Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS. (PMID: 19531213) Havrylov S. … Redowicz M.J. (Proteome Sci 2009) 3

Products for KCTD3 Gene

Sources for KCTD3 Gene

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