KCTD3 Gene
protein-coding GIFtS: 51
GCID: GC01P215740
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Potassium Channel Tetramerization Domain Containing 3(Previous name: potassium channel tetramerisation domain containing 3)
| |
Aliases
for KCTD3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Potassium Channel Tetramerization Domain Containing 31 2 | | Potassium Channel Tetramerisation Domain Containing 31 2 | | Renal Carcinoma Antigen NY-REN-452 3 | | NY-REN-452 | | BTB/POZ Domain-Containing Protein KCTD32 | | NY-REN-45 Antigen2 |
Export aliases for KCTD3 gene to outside databasesPrevious GC identifers: GC01P212357 GC01P212797 GC01P212129 GC01P213807 GC01P186414 |
Summaries
for KCTD3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for KCTD3 Gene: 
KCTD3 (potassium channel tetramerization domain containing 3) is a protein-coding gene. Diseases associated with KCTD3 include gilles de la tourette syndrome, and maturity-onset diabetes of the young, and among its related super-pathways are Melatonin Signaling and Activation of cAMP-Dependent PKA. An important paralog of this gene is SHKBP1.
|
Genomic Views
for KCTD3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NT_167186.1 NC_018912.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCTD3 gene promoter:
HFH-3 CUTL1 YY1 E47 FOXI1 AREB6 MZF-1 Max Hand1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCTD3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q41 Ensembl cytogenetic band: 1q41 HGNC cytogenetic band: 1q41KCTD3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P215740: view genomic region
(about GC identifiers)
Start:
|
215,740,735 bp from pter |
End:
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215,795,149 bp from pter |
Size:
|
54,415 bases |
Orientation:
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plus strand |
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Proteins
for KCTD3 gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
|
UniProtKB/Swiss-Prot: KCTD3_HUMAN, Q9Y597 (See
protein sequence)Recommended Name: BTB/POZ domain-containing protein KCTD3 Size: 815 amino acids; 88984 Da
Miscellaneous: Reacts with sera from 5-25 per cent of cancer patients but not with sera from normal donors.
Seventy per cent of renal cancer patients have antibodies against one or a panel of these antigens
Sequence caution: Sequence=AAH13868.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: A0AV15 D3DTA6 Q49AG7 Q504Q9 Q6PJN6 Q8ND58 Q8NDJ0 Q8WX16Alternative splicing: 3 isoforms: Q9Y597-1 Q9Y597-2 Q9Y597-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KCTD3: NX_Q9Y597
Explore proteomics data for KCTD3 at MOPED
Post-translational modifications:
View modification sites using PhosphoSitePlusView neXtProt modification sites for NX_Q9Y597
KCTD3 Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins: NP_057205.2
ENSEMBL proteins: ENSP00000259154 ENSP00000396726 ENSP00000399962
Human Recombinant Protein Products for KCTD3:
KCTD3 Antibody Products:
Assay Products for KCTD3: |
Protein
Domains /
Families
for KCTD3 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| 5/7 InterPro protein domains (see all 7):Graphical View of Domain Structure for InterPro Entry Q9Y597 ProtoNet protein and cluster: Q9Y597 1 Blocks protein domain: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: KCTD3_HUMAN, Q9Y597Similarity: Belongs to the KCTD3 familySimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 5 WD repeats
KCTD3 for domains About GeneDecksing
|
Function
for KCTD3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
Vector BioLabs,
and Sirion Biotech,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
KCTD3 for ontologies About GeneDecksing
Phenotypes:
3 GenomeRNAi human phenotypes for KCTD3:
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for KCTD3 | |  | Search LifeMap BioReagents cell lines for KCTD3 | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD3 |
Pathways & Interactions
for KCTD3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
SuperPaths for KCTD3 About See pathways by source
| SuperPath | Contained pathways About |
|---|
| 1 | Sweet Taste Signaling | | | 2 | Activation of cAMP-Dependent PKA | | | 3 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | | | 4 | Hepatic ABC Transporters | |
5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCTD3 (see all 13)
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCTD3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/12 Interacting proteins for KCTD3 (Q9Y5971, 3 ENSP000002591544) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051260 | protein homooligomerization |
IEA | -- |
KCTD3 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCTD3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KCTD3
Search CenterWatch for drugs/clinical trials and news about KCTD3
|
Transcripts
for KCTD3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Sirion Biotech,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KCTD3 gene: NM_016121.3 Unigene Cluster for KCTD3: Potassium channel tetramerisation domain containing 3 Hs.335139 [show with all ESTs]Unigene Representative Sequence: NM_0161215 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000259154(uc001hks.3 uc001hkt.3 uc010pub.2 uc009xdn.3)
ENST00000448333 ENST00000452413 ENST00000495537 ENST00000465650
Primer
Products: |  | OriGene qSTAR qPCR primer pairs in human, mouse for KCTD3
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCTD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD3 |
Additional mRNA sequence: AK024547.1 AK055925.1 AK296275.1 AK316272.1 AL833887.1 AL834389.1 BC013868.2 BC037896.1 BC094879.1 BC117188.1 BC126173.1 BC143963.1 14 DOTS entries: DT.91796413 DT.317738 DT.100736505 DT.100783212 DT.121362101 DT.91716350 DT.91835002 DT.121362088 DT.121362105 DT.121362114 DT.121362115 DT.91754867 DT.99982990 DT.86839129 24/227 AceView cDNA sequences (see all 227): BX389664 BM473539 AA505490 CA941810 AI394692 BE350690 AL834389 BX389665 W93028 AA025593 N58984 BU195524 BQ433946 W81099 Z43271 NM_016121 AW264326 AW195137 AW264231 AI445081 AI283161 AI560609 T36035 CR614111
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KCTD3 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | · |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 18c | · | 18d |
|---|
|
| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | | | | | |
| SP4: | | | | | |
| SP5: | | | | |
ECgene alternative splicing isoforms for KCTD3
|
Expression
for KCTD3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KCTD3 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATAATTAAAT
About this image
See KCTD3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCTD3
SOURCE GeneReport for Unigene cluster: Hs.335139
UniProtKB/Swiss-Prot: KCTD3_HUMAN, Q9Y597Tissue specificity: Broadly expressed in normal tissues
SABiosciences Custom PCR Arrays for KCTD3
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for KCTD3
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCTD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD3 |
Orthologs
for KCTD3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KCTD3 gene from 6/14 species (see all 14) About this table
ENSEMBL Gene Tree for KCTD3 (if available)
TreeFam Gene Tree for KCTD3 (if available) |
Paralogs
for KCTD3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KCTD3 gene
- SHKBP12
3 SIMAP similar genes for KCTD3 using alignment to 4 protein entries: KCTD3_HUMAN (see all proteins):SHKBP1 KCTD17 OK/SW-cl.18
KCTD3 for paralogs About GeneDecksing
|
Genomic Variants
for KCTD3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KCTD3 (215740735 - 215795149 bp)
Structural Variations
Database of Genomic Variants (DGV) variations for KCTD3: --
| | SABiosciences Cancer Mutation PCR Assays |
| | SeqTarget long-range PCR primers for resequencing KCTD3 |
|
Disorders
/ Diseases
for KCTD3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OMIM gene information: 613272
OMIM disorders: --
6  diseases for KCTD3: About MalaCardsgilles de la tourette syndrome maturity-onset diabetes of the young cholera renal cell carcinoma
hepatitis neuronitis
1 disease from the University of Copenhagen DISEASES database for KCTD3:Gilles de la Tourette syndrome
KCTD3 for disorders About GeneDecksing
Export disorders for KCTD3 gene to outside databases
|
Publications
for KCTD3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KCTD3 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with KCTD3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2, 3 Scanlan M.J....Old L.J. (1999)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Up-regulation of hyperpolarization-activated cyclic nu cleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramer ization domain-containing protein 3 (KCTD3). (PubMed id 23382386)1 Cao-Ehlker X....Biel M. (2013)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O....Lill R. (2012)
- Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for KCTD3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCTD3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCTD3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCTD3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for KCTD3 gene:
Search GeneIP for patents involving KCTD3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCTD3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCTD3 | | | QIAGEN SeqTarget long-range PCR primers for resequencing KCTD3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCTD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD3 |
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 |  |  |  | |
| | | | Search Tocris compounds for KCTD3 |
| |  |  |  |  | | | | |
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 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD3 |
|  |  |  |  | | | | ThermoFisher Antibodies for KCTD3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD3 |
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