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Aliases for KCTD21 Gene

Aliases for KCTD21 Gene

  • Potassium Channel Tetramerization Domain Containing 21 2 3 5
  • Potassium Channel Tetramerisation Domain Containing 21 2 3
  • KCASH2 3

External Ids for KCTD21 Gene

Previous GeneCards Identifiers for KCTD21 Gene

  • GC11M077560
  • GC11M077882
  • GC11M074180

Summaries for KCTD21 Gene

GeneCards Summary for KCTD21 Gene

KCTD21 (Potassium Channel Tetramerization Domain Containing 21) is a Protein Coding gene. An important paralog of this gene is KCTD11.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD21 Gene

Genomics for KCTD21 Gene

Regulatory Elements for KCTD21 Gene

Promoters for KCTD21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KCTD21 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCTD21 Gene

Chromosome:
11
Start:
78,171,243 bp from pter
End:
78,188,822 bp from pter
Size:
17,580 bases
Orientation:
Minus strand

Genomic View for KCTD21 Gene

Genes around KCTD21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD21 Gene

Proteins for KCTD21 Gene

  • Protein details for KCTD21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0X4-KCD21_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein KCTD21
    Protein Accession:
    Q4G0X4
    Secondary Accessions:
    • B4DTR0

    Protein attributes for KCTD21 Gene

    Size:
    260 amino acids
    Molecular mass:
    29643 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KCTD21 Gene

Proteomics data for KCTD21 Gene at MOPED

Post-translational modifications for KCTD21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD21 Gene

No data available for DME Specific Peptides for KCTD21 Gene

Domains & Families for KCTD21 Gene

Protein Domains for KCTD21 Gene

Suggested Antigen Peptide Sequences for KCTD21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4G0X4

UniProtKB/Swiss-Prot:

KCD21_HUMAN :
  • Contains 1 BTB (POZ) domain.
Domain:
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD21: view

No data available for Gene Families for KCTD21 Gene

Function for KCTD21 Gene

Phenotypes for KCTD21 Gene

genes like me logo Genes that share phenotypes with KCTD21: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD21 Gene

Localization for KCTD21 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCTD21 Gene COMPARTMENTS Subcellular localization image for KCTD21 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD21 Gene

Pathways & Interactions for KCTD21 Gene

SuperPathways for KCTD21 Gene

No Data Available

Interacting Proteins for KCTD21 Gene

Gene Ontology (GO) - Biological Process for KCTD21 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KCTD21 Gene

Drugs & Compounds for KCTD21 Gene

No Compound Related Data Available

Transcripts for KCTD21 Gene

Unigene Clusters for KCTD21 Gene

Potassium channel tetramerisation domain containing 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD21 Gene

No ASD Table

Relevant External Links for KCTD21 Gene

GeneLoc Exon Structure for
KCTD21
ECgene alternative splicing isoforms for
KCTD21

Expression for KCTD21 Gene

mRNA expression in normal human tissues for KCTD21 Gene

Protein differential expression in normal tissues from HIPED for KCTD21 Gene

This gene is overexpressed in Liver (12.3), Testis (7.3), and Frontal cortex (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCTD21 Gene



SOURCE GeneReport for Unigene cluster for KCTD21 Gene Hs.528439

genes like me logo Genes that share expression patterns with KCTD21: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KCTD21 Gene

Orthologs for KCTD21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCTD21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD21 35
  • 99.62 (n)
  • 100 (a)
KCTD21 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCTD21 36
  • 100 (a)
OneToOne
KCTD21 35
  • 94.62 (n)
  • 99.62 (a)
dog
(Canis familiaris)
Mammalia KCTD21 35
  • 94.62 (n)
  • 99.62 (a)
KCTD21 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kctd21 16
Kctd21 35
  • 91.41 (n)
  • 99.62 (a)
Kctd21 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCTD21 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCTD21 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kctd21 35
  • 91.03 (n)
  • 98.46 (a)
chicken
(Gallus gallus)
Aves KCTD21 35
  • 79.36 (n)
  • 91.15 (a)
KCTD21 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCTD21 36
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii kctd7 36
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for KCTD21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCTD21 Gene

ENSEMBL:
Gene Tree for KCTD21 (if available)
TreeFam:
Gene Tree for KCTD21 (if available)

Paralogs for KCTD21 Gene

Paralogs for KCTD21 Gene

(10) SIMAP similar genes for KCTD21 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with KCTD21: view

Variants for KCTD21 Gene

Sequence variations from dbSNP and Humsavar for KCTD21 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs230660 -- 78,175,739(+) TTTTT(A/T)AATTT intron-variant
rs533623 -- 78,181,598(-) ttgac(A/C)accac intron-variant
rs494847 -- 78,177,283(-) CAAAG(A/T)GCCCC intron-variant, utr-variant-5-prime
rs603130 -- 78,177,377(-) CCCAT(A/C)TGCTC intron-variant, utr-variant-5-prime
rs658460 -- 78,180,984(+) aagaa(A/G)gacat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD21 Gene

Variant ID Type Subtype PubMed ID
nsv520740 CNV Gain 19592680
nsv516503 CNV Loss 19592680
nsv527066 CNV Gain 19592680
esv33345 CNV Gain 17666407

Variation tolerance for KCTD21 Gene

Residual Variation Intolerance Score: 42.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD21 Gene

HapMap Linkage Disequilibrium report
KCTD21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD21 Gene

Disorders for KCTD21 Gene

Relevant External Links for KCTD21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCTD21

No disorders were found for KCTD21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD21 Gene

Publications for KCTD21 Gene

  1. Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma. (PMID: 21472142) De Smaele E. … Gulino A. (Neoplasia 2011) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for KCTD21 Gene

Sources for KCTD21 Gene

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