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Aliases for KCTD21 Gene

Aliases for KCTD21 Gene

  • Potassium Channel Tetramerization Domain Containing 21 2 3
  • Potassium Channel Tetramerisation Domain Containing 21 2 3
  • BTB/POZ Domain-Containing Protein KCTD21 3
  • KCASH2 3

External Ids for KCTD21 Gene

Previous GeneCards Identifiers for KCTD21 Gene

  • GC11M077560
  • GC11M077882
  • GC11M074180

Summaries for KCTD21 Gene

GeneCards Summary for KCTD21 Gene

KCTD21 (Potassium Channel Tetramerization Domain Containing 21) is a Protein Coding gene. An important paralog of this gene is KCTD11.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD21 Gene

Genomics for KCTD21 Gene

Regulatory Elements for KCTD21 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCTD21 Gene

78,171,243 bp from pter
78,188,913 bp from pter
17,671 bases
Minus strand

Genomic View for KCTD21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCTD21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD21 Gene

Proteins for KCTD21 Gene

  • Protein details for KCTD21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD21
    Protein Accession:
    Secondary Accessions:
    • B4DTR0

    Protein attributes for KCTD21 Gene

    260 amino acids
    Molecular mass:
    29643 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KCTD21 Gene

Proteomics data for KCTD21 Gene at MOPED

Post-translational modifications for KCTD21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD21 Gene

Antibody Products

No data available for DME Specific Peptides for KCTD21 Gene

Domains for KCTD21 Gene

Protein Domains for KCTD21 Gene

Suggested Antigen Peptide Sequences for KCTD21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD21: view

No data available for Gene Families for KCTD21 Gene

Function for KCTD21 Gene

Gene Ontology (GO) - Molecular Function for KCTD21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KCTD21: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCTD21

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KCTD21 Gene

Localization for KCTD21 Gene

Subcellular locations from

Jensen Localization Image for KCTD21 Gene COMPARTMENTS Subcellular localization image for KCTD21 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD21 Gene

Pathways for KCTD21 Gene

SuperPathways for KCTD21 Gene

No Data Available

Interacting Proteins for KCTD21 Gene

Gene Ontology (GO) - Biological Process for KCTD21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD21: view

No data available for Pathways by source for KCTD21 Gene

Transcripts for KCTD21 Gene

Unigene Clusters for KCTD21 Gene

Potassium channel tetramerisation domain containing 21:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCTD21

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD21 Gene

No ASD Table

Relevant External Links for KCTD21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD21 Gene

mRNA expression in normal human tissues for KCTD21 Gene

Protein differential expression in normal tissues for KCTD21 Gene

This gene is overexpressed in Liver (12.3), Testis (7.3), and Frontal cortex (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCTD21 Gene

SOURCE GeneReport for Unigene cluster for KCTD21 Gene Hs.528439

genes like me logo Genes that share expressions with KCTD21: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for KCTD21 Gene

Orthologs for KCTD21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCTD21 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCTD21 35
  • 94.62 (n)
  • 99.62 (a)
KCTD21 36
  • 100 (a)
(Canis familiaris)
Mammalia KCTD21 35
  • 94.62 (n)
  • 99.62 (a)
KCTD21 36
  • 95 (a)
(Mus musculus)
Mammalia Kctd21 35
  • 91.41 (n)
  • 99.62 (a)
Kctd21 16
Kctd21 36
  • 100 (a)
(Pan troglodytes)
Mammalia KCTD21 35
  • 99.62 (n)
  • 100 (a)
KCTD21 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Kctd21 35
  • 91.03 (n)
  • 98.46 (a)
(Monodelphis domestica)
Mammalia KCTD21 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia KCTD21 36
  • 87 (a)
(Gallus gallus)
Aves KCTD21 35
  • 79.36 (n)
  • 91.15 (a)
KCTD21 36
  • 91 (a)
(Anolis carolinensis)
Reptilia KCTD21 36
  • 89 (a)
(Danio rerio)
Actinopterygii kctd7 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for KCTD21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCTD21 Gene

Gene Tree for KCTD21 (if available)
Gene Tree for KCTD21 (if available)

Paralogs for KCTD21 Gene

Paralogs for KCTD21 Gene

(10) SIMAP similar genes for KCTD21 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with KCTD21: view

Variants for KCTD21 Gene

Sequence variations from dbSNP and Humsavar for KCTD21 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs230656 -- 78,179,683(+) CTCTC(A/G)TGTCT intron-variant, upstream-variant-2KB
rs230657 -- 78,179,257(-) agtcc(A/G)agacc intron-variant, upstream-variant-2KB
rs230658 -- 78,178,653(+) GAACA(A/G)GGTTT intron-variant, upstream-variant-2KB
rs230659 -- 78,178,286(-) tagcc(A/G)ggcct intron-variant, upstream-variant-2KB
rs230660 -- 78,175,739(+) TTTTT(A/T)AATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD21 Gene

Variant ID Type Subtype PubMed ID
nsv520740 CNV Gain 19592680
nsv516503 CNV Loss 19592680
nsv527066 CNV Gain 19592680
esv33345 CNV Gain 17666407

Relevant External Links for KCTD21 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD21 Gene

Disorders for KCTD21 Gene

No disorders were found for KCTD21 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for KCTD21 Gene

Publications for KCTD21 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma. (PMID: 21472142) De Smaele E. … Gulino A. (Neoplasia 2011) 2 3
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KCTD21 Gene

Sources for KCTD21 Gene

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