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KCTD21 Gene

protein-coding   GIFtS: 39
GCID: GC11M077882

Potassium Channel Tetramerization Domain Containing 21

(Previous name: potassium channel tetramerisation domain containing 21)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Channel Tetramerization Domain Containing 211 2
Potassium Channel Tetramerisation Domain Containing 211 2
KCASH22
BTB/POZ Domain-Containing Protein KCTD212

External Ids:    HGNC: 274521   Entrez Gene: 2832192   Ensembl: ENSG000001889977   UniProtKB: Q4G0X43   

Export aliases for KCTD21 gene to outside databases

Previous GC identifers: GC11M077560 GC11M074180


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KCTD21 Gene:
KCTD21 (potassium channel tetramerization domain containing 21) is a protein-coding gene. Diseases associated with KCTD21 include medulloblastoma. An important paralog of this gene is KCTD1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCTD21 gene promoter:
         NF-1   NF-1/L   p53   POU6F1 (c2)   LCR-F1   C/EBPalpha   Egr-4   SEF-1 (1)   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCTD21 promoter sequence
   Search Chromatin IP Primers for KCTD21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCTD21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.1   Ensembl cytogenetic band:  11q14.1   HGNC cytogenetic band: 11q14.1

KCTD21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCTD21 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M077882:  view genomic region     (about GC identifiers)

Start:
77,882,295 bp from pter      End:
77,899,868 bp from pter
Size:
17,574 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCD21_HUMAN, Q4G0X4 (See protein sequence)
Recommended Name: BTB/POZ domain-containing protein KCTD21  
Size: 260 amino acids; 29643 Da
Secondary accessions: B4DTR0

Explore the universe of human proteins at neXtProt for KCTD21: NX_Q4G0X4

Explore proteomics data for KCTD21 at MOPED


See KCTD21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001025030.1  
ENSEMBL proteins: 
 ENSP00000339340   ENSP00000431789   ENSP00000434174   ENSP00000431130   ENSP00000435428  
 ENSP00000435025  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR000210 BTB/POZ-like
 IPR011333 BTB/POZ_fold
 IPR003131 T1-type_BTB

Graphical View of Domain Structure for InterPro Entry Q4G0X4

ProtoNet protein and cluster: Q4G0X4

UniProtKB/Swiss-Prot: KCD21_HUMAN, Q4G0X4
Similarity: Contains 1 BTB (POZ) domain


KCTD21 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
KCTD21 for ontologies           About GeneDecksing


Animal Models:
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SwitchGear 3'UTR luciferase reporter plasmidKCTD21 3' UTR sequence
Inhib. RNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
nucleus2

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCTD21
Interactions:

    Search GeneGlobe Interaction Network for KCTD21

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0051260protein homooligomerization IEA--

KCTD21 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for KCTD21 (KCD21)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for KCTD21 gene: 
NM_001029859.1  

Unigene Cluster for KCTD21:

Potassium channel tetramerisation domain containing 21
Hs.528439  [show with all ESTs]
Unigene Representative Sequence: NM_001029859
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000340067(uc001ozb.3) ENST00000526208 ENST00000525447 ENST00000529350
ENST00000530018 ENST00000528776
miRNA
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hsa-miR-579 hsa-miR-640 hsa-let-7d hsa-miR-374a* hsa-let-7g hsa-miR-374c hsa-let-7a hsa-miR-3116
SwitchGear 3'UTR luciferase reporter plasmidKCTD21 3' UTR sequence
Inhib. RNA
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  QuantiFast Probe-based Assays in human, mouse, rat KCTD21

Additional mRNA sequence: 

AK095233.1 AK300320.1 BC036058.1 

7 DOTS entries:

DT.97812917  DT.91661157  DT.95094402  DT.100745702  DT.95156923  DT.101956952  DT.97764569 

Selected AceView cDNA sequences (see all 41):

N20587 BM669303 AI391633 BE467264 AK095233 CR619406 BM717262 BE249874 
BQ278795 BM817719 BQ029821 BM008320 BI457894 BE181157 BQ215741 BU159762 
BF351701 BI258376 BE745576 AI620540 BG747338 BC036058 BG032396 BM930381 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KCTD21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
KCTD21 Expression
About this image

KCTD21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

KCTD21 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.528439
    Custom PCR Arrays for KCTD21
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD21

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for KCTD21 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Kctd211 , 5 potassium channel tetramerisation domain containing more1, 5 91.41(n)1
99.62(a)1
  7 (53.47 cM)5
6223201  NM_001039039.31  NP_001034128.21 
 973323275 
chicken
(Gallus gallus)
Aves KCTD211 potassium channel tetramerisation domain containing more 79.36(n)
91.15(a)
  428098  XM_004938933.1  XP_004938990.1 
lizard
(Anolis carolinensis)
Reptilia KCTD216
potassium channel tetramerization domain containin...
89(a)
1 ↔ 1
GL343337.1(508327-509109)
zebrafish
(Danio rerio)
Actinopterygii kctd76
potassium channel tetramerisation domain containin...
17(a)
many ↔ many
10(33836377-33845408) ENSDARG00000061580


ENSEMBL Gene Tree for KCTD21 (if available)
TreeFam Gene Tree for KCTD21 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for KCTD21 gene
KCTD12  KCTD82  KCTD152  KCTD162  KCTD42  KCTD112  KCNRG2  KCTD122  
KCTD62  KCTD142  
10 SIMAP similar genes for KCTD21 using alignment to 6 protein entries:     KCD21_HUMAN (see all proteins):
KCTD6    KCTD1    KCTD15    SHKBP1    KCTD11    TNFAIP1
KCTD13    KCTD19    KCTD10    KCTD17

KCTD21 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for KCTD21 (see all 251)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs5957071,2
C,F,A--77887217(+) tgctaT/Ctgtga 1 -- int14Minor allele frequency- C:0.43NA CSA 7
rs1928740511,2
--77887279(+) CTTTCA/GCTGCT 1 -- int10--------
rs1459500271,2
--77887688(+) GGCACA/GGTGAC 1 -- int10--------
rs1846008811,2
--77887689(+) GCACAA/GTGACA 1 -- int10--------
rs1133333351,2
C,F--77887955(+) TTGGGG/AGGCTG 1 -- int11Minor allele frequency- A:0.50WA 2
rs1116275411,2
C,F--77888058(+) GGTCTC/TAAAAA 1 -- int12Minor allele frequency- T:0.03CSA WA 120
rs1421380111,2
--77888074(+) CAAAAA/CCCCAA 1 -- int10--------
rs1881852851,2
--77888083(+) AACCTG/TTCAAG 1 -- int10--------
rs171363251,2
C,F,H--77888270(+) TGCTCG/AACTCT 1 -- int118Minor allele frequency- A:0.05NA NS EA WA 1780
rs6034521,2
H--77888410(-) GGCTTC/TTACTG 1 -- int14Minor allele frequency- T:0.00NS EA 420

HapMap Linkage Disequilibrium report for KCTD21 (77882295 - 77899868 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for KCTD21:    About this table    
Variant IDTypeSubtypePubMed ID
nsv516503CNV Loss19592680
nsv527066CNV Gain19592680
esv33345CNV Gain17666407
nsv520740CNV Gain19592680

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for KCTD21:    
About MalaCards
medulloblastoma


KCTD21 for disorders           About GeneDecksing


Export disorders for KCTD21 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for KCTD21 gene integrated from 10 sources:
(articles sorted by number of sources associating them with KCTD21)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma. (PubMed id 21472142)1, 3 De Smaele E....Gulino A. (Neoplasia 2011)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 283219 HGNC: 27452 AceView: LOC283219 Ensembl:ENSG00000188997 euGenes: HUgn283219
ECgene: KCTD21 H-InvDB: KCTD21

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for KCTD21 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for KCTD21 gene:
Search GeneIP for patents involving KCTD21

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCTD21
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KCTD21
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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