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Aliases for KCTD21 Gene

Aliases for KCTD21 Gene

  • Potassium Channel Tetramerization Domain Containing 21 2 3 5
  • Potassium Channel Tetramerisation Domain Containing 21 2 3
  • BTB/POZ Domain-Containing Protein KCTD21 3
  • KCASH2 3

External Ids for KCTD21 Gene

Previous GeneCards Identifiers for KCTD21 Gene

  • GC11M077560
  • GC11M077882
  • GC11M074180

Summaries for KCTD21 Gene

GeneCards Summary for KCTD21 Gene

KCTD21 (Potassium Channel Tetramerization Domain Containing 21) is a Protein Coding gene. An important paralog of this gene is KCTD11.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD21 Gene

Genomics for KCTD21 Gene

Regulatory Elements for KCTD21 Gene

Enhancers for KCTD21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F078138 1.1 ENCODE 20.2 +49.1 49056 2.6 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 KCTD21-AS1 KCTD21 USP35 THRSP INTS4 ALG8
GH11F078156 1 ENCODE 11.5 +32.2 32172 1.0 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 FOS SP5 USP35 KCTD21 INTS4 GC11P078155 PIR47143 GC11M078165
GH11F078256 1.1 Ensembl ENCODE 10.2 -68.3 -68279 1.4 HDAC1 ARNT RAD21 FOS ZBTB2 CEBPB REST NR2F2 CREB3 TFDP1 ENSG00000254649 GAB2 USP35 KCTD21 NARS2 PIR56737 LOC105369402
GH11F078168 1.1 Ensembl ENCODE 8.3 +19.1 19120 3.0 ARID4B THRB ZSCAN9 RAD21 RARA YY1 MIXL1 THAP11 HMG20B CEBPB NDUFC2 THRSP KCTD21 KCTD21-AS1 AAMDC GC11M078165 PIR40351
GH11F078166 0.7 ENCODE 12.2 +21.7 21658 1.3 ZNF639 LEF1 ESRRA L3MBTL2 TAL1 NR4A1 ZBTB11 SIN3A ARID1B CREB3 KCTD21-AS1 ALG8 KCTD21 USP35 NDUFC2 THRSP GC11M078165 PIR40351
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCTD21 on UCSC Golden Path with GeneCards custom track

Promoters for KCTD21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for KCTD21 Gene

78,171,243 bp from pter
78,188,822 bp from pter
17,580 bases
Minus strand

Genomic View for KCTD21 Gene

Genes around KCTD21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD21 Gene

Proteins for KCTD21 Gene

  • Protein details for KCTD21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD21
    Protein Accession:
    Secondary Accessions:
    • B4DTR0

    Protein attributes for KCTD21 Gene

    260 amino acids
    Molecular mass:
    29643 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KCTD21 Gene

Post-translational modifications for KCTD21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KCTD21 Gene

Domains & Families for KCTD21 Gene

Protein Domains for KCTD21 Gene

Suggested Antigen Peptide Sequences for KCTD21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD21: view

No data available for Gene Families for KCTD21 Gene

Function for KCTD21 Gene

Phenotypes for KCTD21 Gene

genes like me logo Genes that share phenotypes with KCTD21: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD21 Gene

Localization for KCTD21 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD21 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD21 Gene

Pathways & Interactions for KCTD21 Gene

SuperPathways for KCTD21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KCTD21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD21: view

No data available for Pathways by source and SIGNOR curated interactions for KCTD21 Gene

Transcripts for KCTD21 Gene

Unigene Clusters for KCTD21 Gene

Potassium channel tetramerisation domain containing 21:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD21 Gene

No ASD Table

Relevant External Links for KCTD21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCTD21 Gene

Protein differential expression in normal tissues from HIPED for KCTD21 Gene

This gene is overexpressed in Liver (12.3), Testis (7.3), and Frontal cortex (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KCTD21 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCTD21 Gene:


SOURCE GeneReport for Unigene cluster for KCTD21 Gene:

genes like me logo Genes that share expression patterns with KCTD21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for KCTD21 Gene

Orthologs for KCTD21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCTD21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KCTD21 34 35
  • 99.62 (n)
(Bos Taurus)
Mammalia KCTD21 34 35
  • 94.62 (n)
(Canis familiaris)
Mammalia KCTD21 34 35
  • 94.62 (n)
(Monodelphis domestica)
Mammalia KCTD21 35
  • 94 (a)
(Mus musculus)
Mammalia Kctd21 34 16 35
  • 91.41 (n)
(Rattus norvegicus)
Mammalia Kctd21 34
  • 91.03 (n)
(Ornithorhynchus anatinus)
Mammalia KCTD21 35
  • 87 (a)
(Gallus gallus)
Aves KCTD21 34 35
  • 79.36 (n)
(Anolis carolinensis)
Reptilia KCTD21 35
  • 89 (a)
(Danio rerio)
Actinopterygii kctd7 35
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
Species where no ortholog for KCTD21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCTD21 Gene

Gene Tree for KCTD21 (if available)
Gene Tree for KCTD21 (if available)

Paralogs for KCTD21 Gene

Paralogs for KCTD21 Gene

(10) SIMAP similar genes for KCTD21 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with KCTD21: view

Variants for KCTD21 Gene

Sequence variations from dbSNP and Humsavar for KCTD21 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111296651 -- 78,174,585(+) AGTCC(A/T)GGAGA splice-acceptor-variant
rs111399694 -- 78,183,269(+) GGTAG(C/T)TCATG intron-variant
rs111515792 -- 78,182,450(+) TTAGC(A/G)CAATG intron-variant
rs111606252 -- 78,175,611(+) TTATT(A/G)TTCTC intron-variant
rs111627541 -- 78,177,012(+) GGTCT(C/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD21 Gene

Variant ID Type Subtype PubMed ID
esv33345 CNV gain 17666407
nsv1122647 CNV deletion 24896259
nsv516503 CNV loss 19592680
nsv520740 CNV gain 19592680
nsv527066 CNV gain 19592680

Variation tolerance for KCTD21 Gene

Residual Variation Intolerance Score: 42.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD21 Gene

Disorders for KCTD21 Gene

Relevant External Links for KCTD21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KCTD21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD21 Gene

Publications for KCTD21 Gene

  1. Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma. (PMID: 21472142) De Smaele E. … Gulino A. (Neoplasia 2011) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for KCTD21 Gene

Sources for KCTD21 Gene

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