KCTD21 Gene
protein-coding GIFtS: 40
GCID: GC11M077882
|
|
potassium channel tetramerisation domain containing 21
| |
Aliases
for KCTD21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Potassium Channel Tetramerisation Domain Containing 211 2 | | KCASH21 2 | | BTB/POZ Domain-Containing Protein KCTD212 |
Export aliases for KCTD21 gene to outside databasesPrevious GC identifers: GC11M077560 GC11M074180 |
Summaries
for KCTD21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KCTD21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCTD21 gene promoter:
NF-1 NF-1/L p53 POU6F1 (c2) LCR-F1 C/EBPalpha Egr-4 SEF-1 (1) Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCTD21
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD21 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q14.1 Ensembl cytogenetic band: 11q14.1 HGNC cytogenetic band: 11q14.1KCTD21 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M077882: view genomic region
(about GC identifiers)
Start:
|
77,882,295 bp from pter |
End:
|
77,899,868 bp from pter |
Size:
|
17,574 bases |
Orientation:
|
minus strand |
|
Proteins
for KCTD21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KCD21_HUMAN, Q4G0X4 (See
protein sequence)Recommended Name: BTB/POZ domain-containing protein KCTD21 Size: 260 amino acids; 29643 Da
Secondary accessions: B4DTR0Explore the universe of human proteins at neXtProt for KCTD21: NX_Q4G0X4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q4G0X4
KCTD21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001025030.1
ENSEMBL proteins: ENSP00000339340 ENSP00000431789 ENSP00000434174 ENSP00000431130 ENSP00000435428 ENSP00000435025
Human Recombinant Protein Products:
KCTD21 Antibody Products:
Assay Products for KCTD21: |
Protein
Domains /
Families
for KCTD21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCTD21 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q4G0X4ProtoNet protein and cluster: Q4G0X4 UniProtKB/Swiss-Prot: KCD21_HUMAN, Q4G0X4Similarity: Contains 1 BTB (POZ) domain |
Function
for KCTD21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD21 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD21
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KCTD21 (NM_001029859) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCTD21 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD21 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD21 |
|
Pathways & Interactions
for KCTD21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCTD21
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051260 | protein homooligomerization |
IEA | -- |
KCTD21 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCTD21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KCTD21
Search CenterWatch for drugs/clinical trials and news about KCTD21 / KCD21
|
Transcripts
for KCTD21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KCTD21 gene: NM_001029859.1 Unigene Cluster for KCTD21: Potassium channel tetramerisation domain containing 21 Hs.528439 [show with all ESTs]Unigene Representative Sequence: NM_0010298596 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000340067(uc001ozb.3) ENST00000526208 ENST00000525447 ENST00000529350
ENST00000530018 ENST00000528776
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD21 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD21
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KCTD21 (NM_001029859) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCTD21 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD21 |
Additional cDNA sequence: AK095233.1 AK300320.1 BC036058.1 7 DOTS entries: DT.97812917 DT.91661157 DT.95094402 DT.100745702 DT.95156923 DT.101956952 DT.97764569 24/41 AceView cDNA sequences (see all 41): BE467264 AI391633 N20587 BM717262 BM669303 AK095233 CR619406 BE249874 BM930381 AA225604 AI620540 BE745576 BI457894 BQ278795 BG747338 BU159762 BQ029821 BC036058 BM008320 BF351701 BI258376 BG032396 BM817719 BQ215741
GeneLoc Exon Structure
|
Expression
for KCTD21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KCTD21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See KCTD21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCTD21
SOURCE GeneReport for Unigene cluster: Hs.528439
SABiosciences Custom PCR Arrays for KCTD21
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCTD21
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KCTD21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD21 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD21 |
Orthologs
for KCTD21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KCTD21 gene from 2/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
KCTD211 |
potassium channel tetramerisation domain containing more |
79.36(n)
91.15(a) |
|
428098 XM_425657.2 XP_425657.2 |
lizard
(Anolis carolinensis) |
Reptilia |
KCTD216 |
-- |
89(a) |
1 ↔ 1 |
GL343337.1(508327-509109) |
ENSEMBL Gene Tree for KCTD21 (if available)
TreeFam Gene Tree for KCTD21 (if available) |
Paralogs
for KCTD21 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KCTD21 gene
- KCTD12 KCTD152 KCTD82 KCTD162 KCTD42 KCNRG2 KCTD112 KCTD122
- KCTD62 KCTD142
9 SIMAP similar genes for KCTD21 using alignment to 6 protein entries: KCD21_HUMAN (see all proteins):KCTD6 KCTD1 KCTD15 KCTD11 TNFAIP1 KCTD13
KCTD19 KCTD10 KCTD17
KCTD21 for paralogs About GeneDecksing
|
Genomic Variants
for KCTD21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KCTD21 (77882295 - 77899868 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KCTD21
2 CNVs: 6942 48885 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCTD21 |
|
Disorders
/ Diseases
for KCTD21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KCTD21 for disorders About GeneDecksing
1  disease for KCTD21: About MalaCardsmedulloblastoma
Export disorders for KCTD21 gene to outside databases
|
Publications
for KCTD21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KCTD21 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KCTD21) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of KCASH2 and KCA SH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog acti vity in medulloblastoma. (PubMed id 21472142)1, 3 De Smaele E....Gulino A. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for KCTD21 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCTD21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCTD21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCTD21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KCTD21 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KCTD21 gene:
Search GeneIP for patents involving KCTD21
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCTD21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KCTD21 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCTD21 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCTD21 | | | OriGene Protein Over-expression Lysate for KCTD21 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KCTD21 | | OriGene 3'-UTR Clone for KCTD21 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD21 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD21 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KCTD21 | | OriGene Custom Protein Services for KCTD21 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCTD21 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCTD21 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD21 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCTD21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD21 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for KCTD21 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | KCTD21 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD21 |
|  |  |  | | | | ThermoFisher Antibody for KCTD21 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD21 |
|
|
|
|
