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Aliases for KCTD20 Gene

Aliases for KCTD20 Gene

  • Potassium Channel Tetramerization Domain Containing 20 2 3 4
  • Potassium Channel Tetramerisation Domain Containing 20 2 3
  • C6orf69 3 4
  • BTB/POZ Domain-Containing Protein KCTD20 3
  • Chromosome 6 Open Reading Frame 69 2
  • DJ108K11.3 3

External Ids for KCTD20 Gene

Previous Symbols for KCTD20 Gene

  • C6orf69

Summaries for KCTD20 Gene

GeneCards Summary for KCTD20 Gene

KCTD20 (Potassium Channel Tetramerization Domain Containing 20) is a Protein Coding gene. An important paralog of this gene is BTBD10.

UniProtKB/Swiss-Prot for KCTD20 Gene

  • Promotes the phosphorylation of AKT family members.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD20 Gene

Genomics for KCTD20 Gene

Genomic Location for KCTD20 Gene

36,442,767 bp from pter
36,491,143 bp from pter
48,377 bases
Plus strand

Genomic View for KCTD20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCTD20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD20 Gene

Regulatory Elements for KCTD20 Gene

Proteins for KCTD20 Gene

  • Protein details for KCTD20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD20
    Protein Accession:
    Secondary Accessions:
    • B4DZD3
    • B4E2Q3
    • F5H3T3
    • Q5W105
    • Q69YQ7
    • Q8IZ55

    Protein attributes for KCTD20 Gene

    419 amino acids
    Molecular mass:
    47480 Da
    Quaternary structure:
    • Interacts with AKT1; AKT2 and AKT3 (By similarity). Associates with PP2CA (By similarity). Part of a complex containing MARK4 (PubMed:14676191).
    • Sequence=CAH72192.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19118.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KCTD20 Gene


neXtProt entry for KCTD20 Gene

Proteomics data for KCTD20 Gene at MOPED

Post-translational modifications for KCTD20 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys118

No data available for DME Specific Peptides for KCTD20 Gene

Domains for KCTD20 Gene

Protein Domains for KCTD20 Gene


  • Contains 1 BTB (POZ) domain.:
    • Q7Z5Y7
genes like me logo Genes that share domains with KCTD20: view

No data available for Gene Families for KCTD20 Gene

Function for KCTD20 Gene

Molecular function for KCTD20 Gene

UniProtKB/Swiss-Prot Function: Promotes the phosphorylation of AKT family members.

Gene Ontology (GO) - Molecular Function for KCTD20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KCTD20: view
genes like me logo Genes that share phenotypes with KCTD20: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KCTD20 Gene

Localization for KCTD20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCTD20 Gene

Cytoplasm. Note=Colocalizes with BTBD10 in filamentous structures. {ECO:0000250 UniProtKB:Q8CDD8}.

Subcellular locations from

Jensen Localization Image for KCTD20 Gene COMPARTMENTS Subcellular localization image for KCTD20 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KCTD20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with KCTD20: view

Pathways for KCTD20 Gene

SuperPathways for KCTD20 Gene

No Data Available

Interacting Proteins for KCTD20 Gene

Gene Ontology (GO) - Biological Process for KCTD20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042327 positive regulation of phosphorylation ISS --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD20: view

No data available for Pathways by source for KCTD20 Gene

Transcripts for KCTD20 Gene

Unigene Clusters for KCTD20 Gene

Potassium channel tetramerisation domain containing 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD20 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13a · 13b
SP1: - - - - -
SP2: -
SP3: - -
SP4: - - - - - - -
SP5: -
SP6: -
SP7: - - - - - - - - - - -
SP8: - - - - - - - -

Relevant External Links for KCTD20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD20 Gene

mRNA expression in normal human tissues for KCTD20 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCTD20 Gene

SOURCE GeneReport for Unigene cluster for KCTD20 Gene Hs.188757

genes like me logo Genes that share expressions with KCTD20: view

Orthologs for KCTD20 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD20 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KCTD20 36
  • 99.68 (n)
  • 99.52 (a)
KCTD20 37
  • 100 (a)
(Bos Taurus)
Mammalia KCTD20 36
  • 90.21 (n)
  • 93.56 (a)
KCTD20 37
  • 94 (a)
(Canis familiaris)
Mammalia KCTD20 36
  • 90.14 (n)
  • 93.08 (a)
KCTD20 37
  • 93 (a)
(Mus musculus)
Mammalia Kctd20 36
  • 85.12 (n)
  • 90.69 (a)
Kctd20 16
Kctd20 37
  • 91 (a)
(Monodelphis domestica)
Mammalia KCTD20 37
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia KCTD20 37
  • 47 (a)
(Rattus norvegicus)
Mammalia Kctd20 36
  • 83.85 (n)
  • 89.45 (a)
(Gallus gallus)
Aves KCTD20 36
  • 74.39 (n)
  • 80.35 (a)
KCTD20 37
  • 72 (a)
(Anolis carolinensis)
Reptilia KCTD20 37
  • 82 (a)
(Danio rerio)
Actinopterygii KCTD20 37
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta mri 37
  • 42 (a)
(Caenorhabditis elegans)
Secernentea snpc-1.4 37
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5266 37
  • 42 (a)
Species with no ortholog for KCTD20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KCTD20 Gene

Gene Tree for KCTD20 (if available)
Gene Tree for KCTD20 (if available)

Paralogs for KCTD20 Gene

Paralogs for KCTD20 Gene

Selected SIMAP similar genes for KCTD20 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with KCTD20: view

Variants for KCTD20 Gene

Sequence variations from dbSNP and Humsavar for KCTD20 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1191 -- 36,489,577(-) AGCAG(A/G)CTTGG utr-variant-3-prime, nc-transcript-variant
rs584196 -- 36,488,466(-) CTCTG(C/G)ACTCT utr-variant-3-prime, nc-transcript-variant
rs614702 -- 36,490,674(-) ttttt(A/T)aattt utr-variant-3-prime, nc-transcript-variant
rs662384 -- 36,486,423(-) AAAGG(C/T)TGTCA intron-variant
rs853881 -- 36,479,834(-) AGCCT(C/G)GGCGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD20 Gene

Variant ID Type Subtype PubMed ID
nsv885806 CNV Gain 21882294
esv2665343 CNV Deletion 23128226
nsv350047 CNV Loss 16902084

Relevant External Links for KCTD20 Gene

HapMap Linkage Disequilibrium report

Disorders for KCTD20 Gene

Relevant External Links for KCTD20

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with KCTD20: view

No data available for UniProtKB/Swiss-Prot for KCTD20 Gene

Publications for KCTD20 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. (PMID: 14676191) Brajenovic M. … Drewes G. (J. Biol. Chem. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for KCTD20 Gene

Sources for KCTD20 Gene

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