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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCTD20 Gene

protein-coding   GIFtS: 44
GCID: GC06P036410

potassium channel tetramerisation domain containing 20

(Previous name: chromosome 6 open reading frame 69 )
(Previous symbol: C6orf69)
  Search for KCTD20
in our new
 Human Malady Compendium 
Biological research products
for KCTD20
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Potassium Channel Tetramerisation Domain Containing 201 2
C6orf691 2 3
DJ108K11.31
MGC142541
Chromosome 6 Open Reading Frame 691
BTB/POZ Domain-Containing Protein KCTD202

External Ids:    HGNC: 210521   Entrez Gene: 2226582   Ensembl: ENSG000001120787   UniProtKB: Q7Z5Y73   

Export aliases for KCTD20 gene to outside databases

Previous GC identifers: GC06P036519 GC06P036130


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCTD20 gene promoter:
         POU2F2 (Oct-2.1)   FOXF2   POU2F2   POU2F2C   FOXC1   FOXO4   FOXO1a   Pax-4a   POU2F2B   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCTD20 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCTD20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.31

KCTD20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCTD20 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P036410:  view genomic region     (about GC identifiers)

Start:
36,410,544 bp from pter      End:
36,458,920 bp from pter
Size:
48,377 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KCD20_HUMAN, Q7Z5Y7 (See protein sequence)
Recommended Name: BTB/POZ domain-containing protein KCTD20  
Size: 419 amino acids; 47480 Da
Subunit: Part of a complex containing MARK4
Sequence caution: Sequence=CAH72192.1; Type=Erroneous gene model prediction; Sequence=CAI19118.1; Type=Erroneous gene
model prediction;
Secondary accessions: B4E2Q3 Q5W105 Q69YQ7 Q8IZ55
Alternative splicing: 2 isoforms:  Q7Z5Y7-1   Q7Z5Y7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KCTD20: NX_Q7Z5Y7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7Z5Y7

  • KCTD20 Protein expression data from MOPED and PaxDb:    About this image 
    KCTD20 Protein Expression
    REFSEQ proteins: NP_775833.2  
    ENSEMBL proteins: 
     ENSP00000362836   ENSP00000419943   ENSP00000418459   ENSP00000419118   ENSP00000412205  
     ENSP00000265344   ENSP00000417126   ENSP00000439118   ENSP00000440150  

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    Uscn Proteins for KCTD20


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    Uscn ELISAs and CLIAs for KCTD20


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KCTD20 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003131 T1-type_BTB

    Graphical View of Domain Structure for InterPro Entry Q7Z5Y7

    ProtoNet protein and cluster: Q7Z5Y7

    UniProtKB/Swiss-Prot: KCD20_HUMAN, Q7Z5Y7
    Similarity: Contains 1 BTB (POZ) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
         
    KCTD20 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for KCTD20:
     Decreased number of cells in m  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for KCTD20 

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    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate KCTD20 (see all 29):
    hsa-miR-21* hsa-miR-376b hsa-miR-200a hsa-miR-767-5p hsa-miR-29c hsa-miR-29a hsa-miR-488 hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmidKCTD20 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: KCTD20
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD20


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCTD20

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for KCTD20 (Q7Z5Y73 ENSP000003628364) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MARK4Q96L343, ENSP000003008434I2D: score=2 STRING: ENSP00000300843
    MAP3K8P412793I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    PPP1CAENSP000003260314STRING: ENSP00000326031
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051260protein homooligomerization IEA--

    KCTD20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KCTD20
    Search CenterWatch for drugs/clinical trials and news about KCTD20 / KCD20 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KCTD20 gene: 
    NM_173562.3  

    Unigene Cluster for KCTD20:

    Potassium channel tetramerisation domain containing 20
    Hs.188757  [show with all ESTs]
    Unigene Representative Sequence: NM_173562
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373731(uc003ome.3 uc011dtm.2 uc011dtn.2 uc010jwk.3 uc011dto.2)
    ENST00000483557 ENST00000443316 ENST00000498267 ENST00000474988 ENST00000481911
    ENST00000449081 ENST00000265344 ENST00000460983 ENST00000536244 ENST00000544295


    miRNA
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    OriGene 3'-UTR Clone: KCTD20
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCTD20
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate KCTD20 (see all 29):
    hsa-miR-21* hsa-miR-376b hsa-miR-200a hsa-miR-767-5p hsa-miR-29c hsa-miR-29a hsa-miR-488 hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmidKCTD20 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene siRNA: KCTD20
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD20

    Additional cDNA sequence: 

    AK295717.1 AK302861.1 AK304377.1 AK316456.1 AL049282.1 AL832381.1 AY305862.1 BC023525.2 
    BC035879.1 

    9 DOTS entries:

    DT.444756  DT.92419635  DT.100779274  DT.75115694  DT.121397036  DT.40264898  DT.75145768  DT.95374223 
    DT.97844815 

    24/264 AceView cDNA sequences (see all 264):

    AI569100 BQ220604 BQ005224 BM905245 AW236115 CR615950 AI613484 NM_173562 
    BQ009773 W95201 BM480074 AA383963 AL044842 CB960171 AW069861 BC023525 
    AL044883 AI589098 AI364112 CA449096 AI640396 BG054730 C01634 AI129529 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for KCTD20 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13a · 13b
    SP1:                          -     -     -           -                             -                                                         
    SP2:                                                                                -                                                         
    SP3:                          -                       -                                                                                       
    SP4:                          -     -     -           -     -     -                 -                                                         
    SP5:                                                                                -                                                         


    ECgene alternative splicing isoforms for KCTD20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCTD20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    KCTD20 Expression
    About this image
    See KCTD20 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCTD20

    SOURCE GeneReport for Unigene cluster: Hs.188757
        SABiosciences Custom PCR Arrays for KCTD20

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KCTD20 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kctd201 , 5 potassium channel tetramerisation domain containing more1, 5 85.12(n)1
    90.69(a)1
      17 (15.03 cM)5
    669891  NM_025888.51  NP_080164.21 
     289519505 
    chicken
    (Gallus gallus)
    Aves KCTD201 potassium channel tetramerisation domain containing more 75.22(n)
    82.35(a)
      419814  XM_417950.2  XP_417950.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCTD206
    --
    81(a)
    1 ↔ 1
    4(123442329-123450204)
    zebrafish
    (Danio rerio)
    Actinopterygii FP016205.16
    --
    65(a)
    1 ↔ 1
    22(881775-888449)
    fruit fly
    (Drosophila melanogaster)
    Insecta mri6
    mrityu
    42(a)
    1 → many
    3L(200174-202152)
    worm
    (Caenorhabditis elegans)
    Secernentea R05F9.16
    Protein R05F9.1, isoform b
    29(a)
    1 → many
    II(4905006-4911830)


    ENSEMBL Gene Tree for KCTD20 (if available)
    TreeFam Gene Tree for KCTD20 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCTD20 gene
    BTBD102  
    1 SIMAP similar gene for KCTD20 using alignment to 8 protein entries:     KCD20_HUMAN (see all proteins):
    BTBD10

    KCTD20 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/815 NCBI SNPs in KCTD20 are shown (see all 815    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478613581,2
    --36408593(+) TATTAA/CAAGTC 2 -- us2k1 int10--------
    rs1414502751,2
    --36408748(+) TTTGTA/GTACCA 2 -- us2k1 int10--------
    rs1815978271,2
    --36408856(+) CTGGGC/TAACAG 2 -- int1 us2k10--------
    rs728512071,2
    --36408888(+) AAAAAA/GAAAAA 2 -- us2k1 int10--------
    rs1858112121,2
    --36409505(+) GAGAAG/TAGAAA 2 -- int1 us2k10--------
    rs1894418511,2
    --36409506(+) AGAATA/GGAAAT 2 -- us2k1 int10--------
    rs1818665531,2
    --36409511(+) AGAAAC/TGGAAA 2 -- int1 us2k10--------
    rs1862506991,2
    --36409531(+) TAGGCC/TTCTAA 2 -- int1 us2k10--------
    rs1167493041,2
    F--36409577(+) TTTGAA/CAATTA 2 -- int1 us2k11Minor allele frequency- C:0.02WA 118
    rs1145739571,2
    F--36409591(+) TTTTTG/CACCCT 2 -- us2k1 int11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for KCTD20 (36410544 - 36458920 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for KCTD20
         1 CNV: 6488

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCTD20
    DNA2.0 Custom Variant and Variant Library Synthesis for KCTD20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KCTD20 for disorders           About MalaCards

    KCTD20 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: KCTD20 (2 documents)

    Export disorders for KCTD20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCTD20 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with KCTD20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. (PubMed id 14676191)1, 2 Brajenovic M.... Drewes G. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    5. Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (2012)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 222658 HGNC: 21052 AceView: C6orf69 Ensembl:ENSG00000112078 euGenes: HUgn222658
    ECgene: KCTD20 H-InvDB: KCTD20

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCTD20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCTD20 gene:
    Search GeneIP for patents involving KCTD20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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