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Aliases for KCTD2 Gene

Aliases for KCTD2 Gene

  • Potassium Channel Tetramerization Domain Containing 2 2 3
  • Potassium Channel Tetramerization Domain-Containing Protein 2 4
  • Potassium Channel Tetramerisation Domain Containing 2 2
  • KIAA0176 4

External Ids for KCTD2 Gene

Previous GeneCards Identifiers for KCTD2 Gene

  • GC17P073508
  • GC17P073640
  • GC17P070554
  • GC17P073043
  • GC17P068453
  • GC17P073029
  • GC17P073034
  • GC17P073051

Summaries for KCTD2 Gene

GeneCards Summary for KCTD2 Gene

KCTD2 (Potassium Channel Tetramerization Domain Containing 2) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include protein complex binding. An important paralog of this gene is KCTD17.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD2 Gene

Genomics for KCTD2 Gene

Regulatory Elements for KCTD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCTD2 Gene

75,032,567 bp from pter
75,065,889 bp from pter
33,323 bases
Plus strand

Genomic View for KCTD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD2 Gene

Proteins for KCTD2 Gene

  • Protein details for KCTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD2
    Protein Accession:

    Protein attributes for KCTD2 Gene

    263 amino acids
    Molecular mass:
    28527 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA11493.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for KCTD2 Gene

Proteomics data for KCTD2 Gene at MOPED

Post-translational modifications for KCTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCTD2 Gene

Domains & Families for KCTD2 Gene

Protein Domains for KCTD2 Gene


Suggested Antigen Peptide Sequences for KCTD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD2: view

No data available for Gene Families for KCTD2 Gene

Function for KCTD2 Gene

Gene Ontology (GO) - Molecular Function for KCTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0032403 protein complex binding IDA 23209302
genes like me logo Genes that share ontologies with KCTD2: view

Phenotypes for KCTD2 Gene

GenomeRNAi human phenotypes for KCTD2:
genes like me logo Genes that share phenotypes with KCTD2: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCTD2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD2 Gene

Localization for KCTD2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for KCTD2 Gene

Pathways & Interactions for KCTD2 Gene

genes like me logo Genes that share pathways with KCTD2: view

Gene Ontology (GO) - Biological Process for KCTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD2: view

No data available for SIGNOR curated interactions for KCTD2 Gene

Drugs & Compounds for KCTD2 Gene

No Compound Related Data Available

Transcripts for KCTD2 Gene

Unigene Clusters for KCTD2 Gene

Potassium channel tetramerisation domain containing 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCTD2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7

Relevant External Links for KCTD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD2 Gene

mRNA expression in normal human tissues for KCTD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCTD2 Gene

This gene is overexpressed in Brain - Cerebellum (x4.6) and Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for KCTD2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (48.6) and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCTD2 Gene

SOURCE GeneReport for Unigene cluster for KCTD2 Gene Hs.514468

genes like me logo Genes that share expression patterns with KCTD2: view

Protein tissue co-expression partners for KCTD2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KCTD2 Gene

Orthologs for KCTD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCTD2 35
  • 92.37 (n)
  • 99.07 (a)
KCTD2 36
  • 86 (a)
(Canis familiaris)
Mammalia KCTD2 35
  • 91.63 (n)
  • 97.72 (a)
KCTD2 36
  • 98 (a)
(Mus musculus)
Mammalia Kctd2 35
  • 90.11 (n)
  • 96.2 (a)
Kctd2 16
Kctd2 36
  • 96 (a)
(Pan troglodytes)
Mammalia KCTD2 35
  • 99.62 (n)
  • 99.62 (a)
KCTD2 36
  • 100 (a)
(Monodelphis domestica)
Mammalia KCTD2 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia KCTD2 36
  • 98 (a)
(Gallus gallus)
Aves KCTD2 35
  • 83.85 (n)
  • 95.36 (a)
KCTD2 36
  • 84 (a)
(Anolis carolinensis)
Reptilia KCTD2 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd2 35
  • 75.15 (n)
  • 84.82 (a)
(Danio rerio)
Actinopterygii kctd2 35
  • 78.07 (n)
  • 94.82 (a)
kctd2 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta inc 36
  • 57 (a)
(Caenorhabditis elegans)
Secernentea tag-303 35
  • 57.69 (n)
  • 57.51 (a)
inso-1 36
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8310 36
  • 65 (a)
Species with no ortholog for KCTD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD2 Gene

Gene Tree for KCTD2 (if available)
Gene Tree for KCTD2 (if available)

Paralogs for KCTD2 Gene

Paralogs for KCTD2 Gene

(2) SIMAP similar genes for KCTD2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with KCTD2: view

Variants for KCTD2 Gene

Sequence variations from dbSNP and Humsavar for KCTD2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1127088 -- 75,064,397(+) TCCTT(C/T)TATGA utr-variant-3-prime, nc-transcript-variant
rs1491765 -- 75,032,828(+) GCAGA(A/G)TGCTG intron-variant
rs4076115 -- 75,063,741(+) CAGCC(A/G)GGACC utr-variant-3-prime, nc-transcript-variant
rs4365317 -- 75,063,725(+) CCTCA(C/G)CTTTC utr-variant-3-prime, nc-transcript-variant
rs4447462 -- 75,051,388(+) caagc(A/G)atttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD2 Gene

Variant ID Type Subtype PubMed ID
nsv908744 CNV Loss 21882294
nsv908753 CNV Loss 21882294

Variation tolerance for KCTD2 Gene

Residual Variation Intolerance Score: 25.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.27; 85.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD2 Gene

Disorders for KCTD2 Gene

Relevant External Links for KCTD2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KCTD2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD2 Gene

Publications for KCTD2 Gene

  1. Radiation hybrid map, physical map, and low-pass genomic sequence of the canine prcd region on CFA9 and comparative mapping with the syntenic region on human chromosome 17. (PMID: 12620391) Sidjanin D.J. … Aguirre G. (Genomics 2003) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67
  4. ATP5H/KCTD2 locus is associated with Alzheimer's disease risk. (PMID: 23857120) Boada M. … Ruiz A. (Mol. Psychiatry 2014) 67
  5. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PMID: 23402259) Chen R. … Zhang N. (J. Proteome Res. 2013) 67

Products for KCTD2 Gene

Sources for KCTD2 Gene

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