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Aliases for KCTD2 Gene

Aliases for KCTD2 Gene

  • Potassium Channel Tetramerization Domain Containing 2 2 3 5
  • Potassium Channel Tetramerization Domain-Containing Protein 2 4
  • Potassium Channel Tetramerisation Domain Containing 2 2
  • KIAA0176 4

External Ids for KCTD2 Gene

Previous GeneCards Identifiers for KCTD2 Gene

  • GC17P073508
  • GC17P073640
  • GC17P070554
  • GC17P073043
  • GC17P068453
  • GC17P073029
  • GC17P073034
  • GC17P073051

Summaries for KCTD2 Gene

GeneCards Summary for KCTD2 Gene

KCTD2 (Potassium Channel Tetramerization Domain Containing 2) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include protein complex binding. An important paralog of this gene is KCTD5.

Additional gene information for KCTD2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD2 Gene

Genomics for KCTD2 Gene

GeneHancer (GH) Regulatory Elements for KCTD2 Gene

Promoters and enhancers for KCTD2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I075046 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 562.1 +14.9 14883 3.6 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ATP5PD KCTD2 PIR61802 GC17P075050 NUP85 ENSG00000266980 SLC25A19
GH17I075010 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.4 -20.4 -20365 3.7 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MRPL58 UNK GGA3 HID1 NUP85 CDK3 NT5C ENSG00000266980 KCTD2 CDR2L
GH17I075031 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 15.9 +2.1 2054 5.8 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 TRR-TCG3-1 TRR-CCT2-1 TRR-CCT1-1 GC17M075035 GC17P075036 GC17P075034 NUP85 UNK NT5C GGA3
GH17I075507 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.6 +481.0 480981 11.8 CLOCK MLX ZFP64 DMAP1 SLC30A9 ZNF213 ZNF143 SP3 NFYC SSRP1 TSEN54 CASKIN2 NUP85 ENSG00000267342 ENSG00000266980 NT5C LLGL2 NAT9 EXOC7 UNK
GH17I074986 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 -44.4 -44379 2.9 HDGF ARID4B SIN3A FEZF1 ZNF213 FOS SP3 SP5 NFYC REST CDR2L HID1 KCTD2 MRPL38 ATP5PD RAB37 GC17M074998
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KCTD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCTD2 gene promoter:

Genomic Locations for KCTD2 Gene

Genomic Locations for KCTD2 Gene
33,323 bases
Plus strand

Genomic View for KCTD2 Gene

Genes around KCTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD2 Gene

Proteins for KCTD2 Gene

  • Protein details for KCTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD2
    Protein Accession:

    Protein attributes for KCTD2 Gene

    263 amino acids
    Molecular mass:
    28527 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA11493.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for KCTD2 Gene

Post-translational modifications for KCTD2 Gene

No Post-translational modifications

Other Protein References for KCTD2 Gene

No data available for DME Specific Peptides for KCTD2 Gene

Domains & Families for KCTD2 Gene

Gene Families for KCTD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KCTD2 Gene

Suggested Antigen Peptide Sequences for KCTD2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KCTD2: view

No data available for UniProtKB/Swiss-Prot for KCTD2 Gene

Function for KCTD2 Gene

Phenotypes From GWAS Catalog for KCTD2 Gene

Gene Ontology (GO) - Molecular Function for KCTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032403 protein complex binding IDA 23209302
GO:0097602 cullin family protein binding IBA --
genes like me logo Genes that share ontologies with KCTD2: view
genes like me logo Genes that share phenotypes with KCTD2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD2 Gene

Localization for KCTD2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD2 gene
Compartment Confidence
cytoskeleton 2
nucleus 2
plasma membrane 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KCTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KCTD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KCTD2 Gene

Pathways & Interactions for KCTD2 Gene

genes like me logo Genes that share pathways with KCTD2: view

Gene Ontology (GO) - Biological Process for KCTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD2: view

No data available for SIGNOR curated interactions for KCTD2 Gene

Drugs & Compounds for KCTD2 Gene

No Compound Related Data Available

Transcripts for KCTD2 Gene

Unigene Clusters for KCTD2 Gene

Potassium channel tetramerisation domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7

Relevant External Links for KCTD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCTD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCTD2 Gene

This gene is overexpressed in Brain - Cerebellum (x4.6) and Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for KCTD2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (48.6) and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KCTD2 Gene

Protein tissue co-expression partners for KCTD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCTD2 Gene:


SOURCE GeneReport for Unigene cluster for KCTD2 Gene:


Evidence on tissue expression from TISSUES for KCTD2 Gene

  • Bone marrow(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with KCTD2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCTD2 Gene

Orthologs for KCTD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KCTD2 33 34
  • 99.62 (n)
(Ornithorhynchus anatinus)
Mammalia KCTD2 34
  • 98 (a)
(Bos Taurus)
Mammalia KCTD2 33 34
  • 92.37 (n)
(Canis familiaris)
Mammalia KCTD2 33 34
  • 91.63 (n)
(Mus musculus)
Mammalia Kctd2 33 16 34
  • 90.11 (n)
(Monodelphis domestica)
Mammalia KCTD2 34
  • 81 (a)
(Gallus gallus)
Aves KCTD2 33 34
  • 83.85 (n)
(Anolis carolinensis)
Reptilia KCTD2 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd2 33
  • 75.15 (n)
(Danio rerio)
Actinopterygii kctd2 33 34
  • 78.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta inc 34
  • 57 (a)
(Caenorhabditis elegans)
Secernentea tag-303 33
  • 57.69 (n)
inso-1 34
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8310 34
  • 65 (a)
Species where no ortholog for KCTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD2 Gene

Gene Tree for KCTD2 (if available)
Gene Tree for KCTD2 (if available)

Paralogs for KCTD2 Gene

Paralogs for KCTD2 Gene

(2) SIMAP similar genes for KCTD2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with KCTD2: view

Variants for KCTD2 Gene

Sequence variations from dbSNP and Humsavar for KCTD2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000112682 -- 75,051,978(+) A/G intron_variant
rs1000115515 -- 75,033,624(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000204754 -- 75,043,094(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000353180 -- 75,062,564(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000438449 -- 75,057,370(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD2 Gene

Variant ID Type Subtype PubMed ID
esv1720628 CNV deletion 17803354
esv2566082 CNV deletion 19546169
esv2716235 CNV deletion 23290073
esv3554781 CNV deletion 23714750
esv3641253 CNV gain 21293372
esv3641254 CNV loss 21293372
esv3893044 CNV loss 25118596
nsv112456 CNV deletion 16902084

Variation tolerance for KCTD2 Gene

Residual Variation Intolerance Score: 25.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.27; 85.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCTD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD2 Gene

Disorders for KCTD2 Gene

Additional Disease Information for KCTD2

No disorders were found for KCTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD2 Gene

Publications for KCTD2 Gene

  1. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M … Deary IJ (Biological psychology 2011) 3 44 58
  2. Radiation hybrid map, physical map, and low-pass genomic sequence of the canine prcd region on CFA9 and comparative mapping with the syntenic region on human chromosome 17. (PMID: 12620391) Sidjanin DJ … Aguirre G (Genomics 2003) 2 3 58
  3. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. KCTD2, an adaptor of Cullin3 E3 ubiquitin ligase, suppresses gliomagenesis by destabilizing c-Myc. (PMID: 28060381) Kim EJ … Kim H (Cell death and differentiation 2017) 3 58

Products for KCTD2 Gene

Sources for KCTD2 Gene

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