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Aliases for KCTD2 Gene

Aliases for KCTD2 Gene

  • Potassium Channel Tetramerization Domain Containing 2 2 3
  • KIAA0176 4 6
  • Potassium Channel Tetramerization Domain-Containing Protein 2 4
  • Potassium Channel Tetramerisation Domain Containing 2 2

External Ids for KCTD2 Gene

Summaries for KCTD2 Gene

GeneCards Summary for KCTD2 Gene

KCTD2 (Potassium Channel Tetramerization Domain Containing 2) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. An important paralog of this gene is KCTD17.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD2 Gene

Genomics for KCTD2 Gene

Genomic Location for KCTD2 Gene

Start:
75,032,575 bp from pter
End:
75,065,889 bp from pter
Size:
33,315 bases
Orientation:
Plus strand

Genomic View for KCTD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD2 Gene

Regulatory Elements for KCTD2 Gene

Proteins for KCTD2 Gene

  • Protein details for KCTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14681-KCTD2_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein KCTD2
    Protein Accession:
    Q14681
    Secondary Accessions:

    Protein attributes for KCTD2 Gene

    Size:
    263 amino acids
    Molecular mass:
    28527 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA11493.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for KCTD2 Gene

Proteomics data for KCTD2 Gene at MOPED

Post-translational modifications for KCTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCTD2 Gene

Domains for KCTD2 Gene

Protein Domains for KCTD2 Gene

UniProtKB/Swiss-Prot:

KCTD2_HUMAN
Domain:
  • Contains 1 BTB (POZ) domain.:
    • Q14681
genes like me logo Genes that share domains with KCTD2: view

No data available for Gene Families for KCTD2 Gene

Function for KCTD2 Gene

Gene Ontology (GO) - Molecular Function for KCTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0032403 protein complex binding IDA 23209302
genes like me logo Genes that share ontologies with KCTD2: view

miRNA for KCTD2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KCTD2 Gene

Localization for KCTD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCTD2 Gene COMPARTMENTS Subcellular localization image for KCTD2 gene
Compartment Confidence
cytoskeleton 2
nucleus 2
cytosol 1
golgi apparatus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for KCTD2 Gene

Pathways for KCTD2 Gene

genes like me logo Genes that share pathways with KCTD2: view

Gene Ontology (GO) - Biological Process for KCTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD2: view

Transcripts for KCTD2 Gene

Unigene Clusters for KCTD2 Gene

Potassium channel tetramerisation domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2:

Relevant External Links for KCTD2 Gene

GeneLoc Exon Structure for
KCTD2
ECgene alternative splicing isoforms for
KCTD2

Expression for KCTD2 Gene

mRNA expression in normal human tissues for KCTD2 Gene

mRNA differential expression in normal tissues according to GTEx for KCTD2 Gene

This gene is overexpressed in Brain - Cerebellum (4.6) and Brain - Cerebellar Hemisphere (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCTD2 Gene

SOURCE GeneReport for Unigene cluster for KCTD2 Gene Hs.514468

genes like me logo Genes that share expressions with KCTD2: view

Orthologs for KCTD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD2 36
  • 99.62 (n)
  • 99.62 (a)
KCTD2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCTD2 36
  • 92.37 (n)
  • 99.07 (a)
KCTD2 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCTD2 36
  • 91.63 (n)
  • 97.72 (a)
KCTD2 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kctd2 36
  • 90.11 (n)
  • 96.2 (a)
Kctd2 16
Kctd2 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCTD2 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCTD2 37
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCTD2 36
  • 83.85 (n)
  • 95.36 (a)
KCTD2 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCTD2 37
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd2 36
  • 75.15 (n)
  • 84.82 (a)
zebrafish
(Danio rerio)
Actinopterygii kctd2 36
  • 78.07 (n)
  • 94.82 (a)
kctd2 37
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta inc 37
  • 57 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea inso-1 37
  • 43 (a)
OneToMany
tag-303 36
  • 57.69 (n)
  • 57.51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8310 37
  • 65 (a)
OneToMany
Species with no ortholog for KCTD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD2 Gene

ENSEMBL:
Gene Tree for KCTD2 (if available)
TreeFam:
Gene Tree for KCTD2 (if available)

Paralogs for KCTD2 Gene

Paralogs for KCTD2 Gene

Selected SIMAP similar genes for KCTD2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with KCTD2: view

Variants for KCTD2 Gene

Sequence variations from dbSNP and Humsavar for KCTD2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1127088 -- 75,064,397(+) TCCTT(C/T)TATGA utr-variant-3-prime, nc-transcript-variant
rs4076115 -- 75,063,741(+) CAGCC(A/G)GGACC utr-variant-3-prime, nc-transcript-variant
rs4365317 -- 75,063,725(+) CCTCA(C/G)CTTTC utr-variant-3-prime, nc-transcript-variant
rs4447462 -- 75,051,388(+) caagc(A/G)atttt intron-variant
rs6146149 -- 75,062,744(+) ACACA(-/CACACACACAC)GCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD2 Gene

Variant ID Type Subtype PubMed ID
nsv908744 CNV Loss 21882294
nsv908753 CNV Loss 21882294

Relevant External Links for KCTD2 Gene

HapMap Linkage Disequilibrium report
KCTD2

Disorders for KCTD2 Gene

Relevant External Links for KCTD2

Genetic Association Database (GAD)
KCTD2
genes like me logo Genes that share disorders with KCTD2: view

No data available for UniProtKB/Swiss-Prot for KCTD2 Gene

Publications for KCTD2 Gene

  1. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M. … Deary I.J. (Biol Psychol 2011) 3 49
  2. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  3. Radiation hybrid map, physical map, and low-pass genomic sequence of the canine prcd region on CFA9 and comparative mapping with the syntenic region on human chromosome 17. (PMID: 12620391) Sidjanin D.J. … Aguirre G. (Genomics 2003) 2 3
  4. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3
  5. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 3

Products for KCTD2 Gene

Sources for KCTD2 Gene

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