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Aliases for KCTD2 Gene

Aliases for KCTD2 Gene

  • Potassium Channel Tetramerization Domain Containing 2 2 3 5
  • Potassium Channel Tetramerization Domain-Containing Protein 2 4
  • Potassium Channel Tetramerisation Domain Containing 2 2
  • KIAA0176 4

External Ids for KCTD2 Gene

Previous GeneCards Identifiers for KCTD2 Gene

  • GC17P073508
  • GC17P073640
  • GC17P070554
  • GC17P073043
  • GC17P068453
  • GC17P073029
  • GC17P073034
  • GC17P073051

Summaries for KCTD2 Gene

GeneCards Summary for KCTD2 Gene

KCTD2 (Potassium Channel Tetramerization Domain Containing 2) is a Protein Coding gene. Among its related pathways are Hepatic ABC Transporters and Sweet Taste Signaling. GO annotations related to this gene include protein complex binding. An important paralog of this gene is KCTD5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD2 Gene

Genomics for KCTD2 Gene

Regulatory Elements for KCTD2 Gene

Promoters for KCTD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KCTD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCTD2 Gene

Chromosome:
17
Start:
75,032,567 bp from pter
End:
75,065,889 bp from pter
Size:
33,323 bases
Orientation:
Plus strand

Genomic View for KCTD2 Gene

Genes around KCTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD2 Gene

Proteins for KCTD2 Gene

  • Protein details for KCTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14681-KCTD2_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein KCTD2
    Protein Accession:
    Q14681

    Protein attributes for KCTD2 Gene

    Size:
    263 amino acids
    Molecular mass:
    28527 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA11493.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for KCTD2 Gene

Proteomics data for KCTD2 Gene at MOPED

Post-translational modifications for KCTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCTD2 Gene

Domains & Families for KCTD2 Gene

Protein Domains for KCTD2 Gene

Suggested Antigen Peptide Sequences for KCTD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q14681

UniProtKB/Swiss-Prot:

KCTD2_HUMAN :
  • Contains 1 BTB (POZ) domain.
Domain:
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD2: view

No data available for Gene Families for KCTD2 Gene

Function for KCTD2 Gene

Phenotypes for KCTD2 Gene

genes like me logo Genes that share phenotypes with KCTD2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD2 Gene

Localization for KCTD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCTD2 Gene COMPARTMENTS Subcellular localization image for KCTD2 gene
Compartment Confidence
cytoskeleton 2
nucleus 2
cytosol 1
golgi apparatus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD2 Gene

Pathways & Interactions for KCTD2 Gene

genes like me logo Genes that share pathways with KCTD2: view

Pathways by source for KCTD2 Gene

Gene Ontology (GO) - Biological Process for KCTD2 Gene

None

No data available for SIGNOR curated interactions for KCTD2 Gene

Drugs & Compounds for KCTD2 Gene

No Compound Related Data Available

Transcripts for KCTD2 Gene

Unigene Clusters for KCTD2 Gene

Potassium channel tetramerisation domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2:

Relevant External Links for KCTD2 Gene

GeneLoc Exon Structure for
KCTD2
ECgene alternative splicing isoforms for
KCTD2

Expression for KCTD2 Gene

mRNA expression in normal human tissues for KCTD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCTD2 Gene

This gene is overexpressed in Brain - Cerebellum (x4.6) and Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for KCTD2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (48.6) and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCTD2 Gene



SOURCE GeneReport for Unigene cluster for KCTD2 Gene Hs.514468

genes like me logo Genes that share expression patterns with KCTD2: view

Protein tissue co-expression partners for KCTD2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KCTD2 Gene

Orthologs for KCTD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD2 36
  • 100 (a)
OneToOne
KCTD2 35
  • 99.62 (n)
  • 99.62 (a)
cow
(Bos Taurus)
Mammalia KCTD2 35
  • 92.37 (n)
  • 99.07 (a)
KCTD2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCTD2 36
  • 98 (a)
OneToOne
KCTD2 35
  • 91.63 (n)
  • 97.72 (a)
mouse
(Mus musculus)
Mammalia Kctd2 16
Kctd2 36
  • 96 (a)
OneToOne
Kctd2 35
  • 90.11 (n)
  • 96.2 (a)
oppossum
(Monodelphis domestica)
Mammalia KCTD2 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCTD2 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCTD2 35
  • 83.85 (n)
  • 95.36 (a)
KCTD2 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCTD2 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd2 35
  • 75.15 (n)
  • 84.82 (a)
zebrafish
(Danio rerio)
Actinopterygii kctd2 36
  • 75 (a)
OneToOne
kctd2 35
  • 78.07 (n)
  • 94.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta inc 36
  • 57 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-303 35
  • 57.69 (n)
  • 57.51 (a)
inso-1 36
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8310 36
  • 65 (a)
OneToMany
Species with no ortholog for KCTD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD2 Gene

ENSEMBL:
Gene Tree for KCTD2 (if available)
TreeFam:
Gene Tree for KCTD2 (if available)

Paralogs for KCTD2 Gene

Paralogs for KCTD2 Gene

(2) SIMAP similar genes for KCTD2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with KCTD2: view

Variants for KCTD2 Gene

Sequence variations from dbSNP and Humsavar for KCTD2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs4789126 -- 75,032,295(+) TTCCC(C/G)TACAG upstream-variant-2KB
rs4789127 -- 75,032,657(+) AGGTT(A/G)GAGCT nc-transcript-variant
rs4076115 -- 75,063,741(+) CAGCC(A/G)GGACC nc-transcript-variant, utr-variant-3-prime
rs4365317 -- 75,063,725(+) CCTCA(C/G)CTTTC nc-transcript-variant, utr-variant-3-prime
rs4447462 -- 75,051,388(+) caagc(A/G)atttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD2 Gene

Variant ID Type Subtype PubMed ID
nsv908744 CNV Loss 21882294
nsv908753 CNV Loss 21882294

Variation tolerance for KCTD2 Gene

Residual Variation Intolerance Score: 25.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.27; 85.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD2 Gene

HapMap Linkage Disequilibrium report
KCTD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD2 Gene

Disorders for KCTD2 Gene

Relevant External Links for KCTD2

Genetic Association Database (GAD)
KCTD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCTD2

No disorders were found for KCTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD2 Gene

Publications for KCTD2 Gene

  1. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M. … Deary I.J. (Biol Psychol 2011) 3 48 67
  2. Radiation hybrid map, physical map, and low-pass genomic sequence of the canine prcd region on CFA9 and comparative mapping with the syntenic region on human chromosome 17. (PMID: 12620391) Sidjanin D.J. … Aguirre G. (Genomics 2003) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. ATP5H/KCTD2 locus is associated with Alzheimer's disease risk. (PMID: 23857120) Boada M. … Ruiz A. (Mol. Psychiatry 2014) 3

Products for KCTD2 Gene

Sources for KCTD2 Gene

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