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Aliases for KCTD2 Gene

Aliases for KCTD2 Gene

  • Potassium Channel Tetramerization Domain Containing 2 2 3 5
  • Potassium Channel Tetramerization Domain-Containing Protein 2 4
  • Potassium Channel Tetramerisation Domain Containing 2 2
  • KIAA0176 4

External Ids for KCTD2 Gene

Previous GeneCards Identifiers for KCTD2 Gene

  • GC17P073508
  • GC17P073640
  • GC17P070554
  • GC17P073043
  • GC17P068453
  • GC17P073029
  • GC17P073034
  • GC17P073051

Summaries for KCTD2 Gene

GeneCards Summary for KCTD2 Gene

KCTD2 (Potassium Channel Tetramerization Domain Containing 2) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling and Hepatic ABC Transporters. GO annotations related to this gene include protein complex binding. An important paralog of this gene is KCTD5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD2 Gene

Genomics for KCTD2 Gene

Regulatory Elements for KCTD2 Gene

Enhancers for KCTD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F075010 1.5 FANTOM5 ENCODE 15.4 -20.4 -20365 3.7 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 UNK HID1 ENSG00000267801 ENSG00000266980 ENSG00000264829 NUP85 KCTD2 CDR2L NT5C HID1-AS1
GH17F074511 1.8 FANTOM5 Ensembl ENCODE 11.3 -519.0 -518964 3.3 HDGF PKNOX1 ARNT SIN3A YBX1 FEZF1 ZNF2 ZNF302 CBX5 ZNF416 NUP85 NAT9 NT5C CD300E RN7SL573P LOC100130520 ENSG00000266765 ENSG00000265927 LINC02092 ENSG00000265935
GH17F075075 1.6 FANTOM5 Ensembl ENCODE 11.8 +46.2 46234 6.0 MLX ARID4B DMAP1 ZNF48 ZNF143 FOS SP5 MXD4 TBX21 PPARG ATP5H HN1 KCTD2 MRPS7 TMEM94 MIR6785 TRIM80P SLC16A5 HID1 MRPL58
GH17F075425 1.6 FANTOM5 Ensembl ENCODE 11.3 +396.0 396032 5.4 HDGF MLX ARID4B SIN3A YBX1 DMAP1 YY1 ZNF143 ZNF207 FOS UNK NUP85 TRIM65 NT5C TSEN54 CASKIN2 KCTD2 NAT9 GRB2 MIF4GD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCTD2 on UCSC Golden Path with GeneCards custom track

Promoters for KCTD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001538177 1533 3401 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for KCTD2 Gene

75,032,567 bp from pter
75,065,889 bp from pter
33,323 bases
Plus strand

Genomic View for KCTD2 Gene

Genes around KCTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD2 Gene

Proteins for KCTD2 Gene

  • Protein details for KCTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD2
    Protein Accession:

    Protein attributes for KCTD2 Gene

    263 amino acids
    Molecular mass:
    28527 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA11493.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for KCTD2 Gene

Post-translational modifications for KCTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD2 Gene

No data available for DME Specific Peptides for KCTD2 Gene

Domains & Families for KCTD2 Gene

Protein Domains for KCTD2 Gene

Suggested Antigen Peptide Sequences for KCTD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD2: view

No data available for Gene Families for KCTD2 Gene

Function for KCTD2 Gene

Gene Ontology (GO) - Molecular Function for KCTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032403 protein complex binding IDA 23209302
GO:0097602 cullin family protein binding IBA --
genes like me logo Genes that share ontologies with KCTD2: view
genes like me logo Genes that share phenotypes with KCTD2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD2 Gene

Localization for KCTD2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD2 gene
Compartment Confidence
cytoskeleton 2
nucleus 2
plasma membrane 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KCTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KCTD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KCTD2 Gene

Pathways & Interactions for KCTD2 Gene

genes like me logo Genes that share pathways with KCTD2: view

Gene Ontology (GO) - Biological Process for KCTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD2: view

No data available for SIGNOR curated interactions for KCTD2 Gene

Transcripts for KCTD2 Gene

Unigene Clusters for KCTD2 Gene

Potassium channel tetramerisation domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7

Relevant External Links for KCTD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCTD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCTD2 Gene

This gene is overexpressed in Brain - Cerebellum (x4.6) and Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for KCTD2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (48.6) and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KCTD2 Gene

Protein tissue co-expression partners for KCTD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCTD2 Gene:


SOURCE GeneReport for Unigene cluster for KCTD2 Gene:

genes like me logo Genes that share expression patterns with KCTD2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for KCTD2 Gene

Orthologs for KCTD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KCTD2 34 35
  • 99.62 (n)
(Ornithorhynchus anatinus)
Mammalia KCTD2 35
  • 98 (a)
(Bos Taurus)
Mammalia KCTD2 34 35
  • 92.37 (n)
(Canis familiaris)
Mammalia KCTD2 34 35
  • 91.63 (n)
(Mus musculus)
Mammalia Kctd2 34 16 35
  • 90.11 (n)
(Monodelphis domestica)
Mammalia KCTD2 35
  • 81 (a)
(Gallus gallus)
Aves KCTD2 34 35
  • 83.85 (n)
(Anolis carolinensis)
Reptilia KCTD2 35
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd2 34
  • 75.15 (n)
(Danio rerio)
Actinopterygii kctd2 34 35
  • 78.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta inc 35
  • 57 (a)
(Caenorhabditis elegans)
Secernentea tag-303 34
  • 57.69 (n)
inso-1 35
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8310 35
  • 65 (a)
Species where no ortholog for KCTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD2 Gene

Gene Tree for KCTD2 (if available)
Gene Tree for KCTD2 (if available)

Paralogs for KCTD2 Gene

Paralogs for KCTD2 Gene

(2) SIMAP similar genes for KCTD2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with KCTD2: view

Variants for KCTD2 Gene

Sequence variations from dbSNP and Humsavar for KCTD2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10512598 -- 75,042,037(-) GTGGT(C/T)GATTG intron-variant
rs10533801 -- 75,062,700(+) CCCCA(-/AC)ACACA intron-variant
rs11077772 -- 75,039,603(+) TCTCT(C/T)TGGTG intron-variant
rs11077773 -- 75,063,978(+) TGTTA(C/T)GTTGT nc-transcript-variant, utr-variant-3-prime
rs111249217 -- 75,034,446(+) GGGAC(A/T)CGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD2 Gene

Variant ID Type Subtype PubMed ID
nsv112456 CNV deletion 16902084
esv3893044 CNV loss 25118596
esv3641254 CNV loss 21293372
esv3641253 CNV gain 21293372
esv3554781 CNV deletion 23714750
esv2716235 CNV deletion 23290073
esv2566082 CNV deletion 19546169
esv1720628 CNV deletion 17803354

Variation tolerance for KCTD2 Gene

Residual Variation Intolerance Score: 25.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.27; 85.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD2 Gene

Disorders for KCTD2 Gene

Relevant External Links for KCTD2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KCTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD2 Gene

Publications for KCTD2 Gene

  1. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M. … Deary I.J. (Biol Psychol 2011) 3 46 64
  2. Radiation hybrid map, physical map, and low-pass genomic sequence of the canine prcd region on CFA9 and comparative mapping with the syntenic region on human chromosome 17. (PMID: 12620391) Sidjanin D.J. … Aguirre G. (Genomics 2003) 2 3 64
  3. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for KCTD2 Gene

Sources for KCTD2 Gene

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