KCTD2 Gene
protein-coding GIFtS: 46
GCID: GC17P073029
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potassium channel tetramerisation domain containing 2
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Aliases
for KCTD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Potassium Channel Tetramerisation Domain Containing 21 2 | | KIAA01761 3 5 | | Potassium Channel Tetramerization Domain-Containing Protein 22 3 | | BTB/POZ Domain-Containing Protein KCTD22 |
Export aliases for KCTD2 gene to outside databasesPrevious GC identifers: GC17P073508 GC17P073640 GC17P070554 GC17P073043 GC17P068453 |
Summaries
for KCTD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KCTD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCTD2 gene promoter:
Pbx1a LUN-1 STAT5A Ik-3 GATA-2 RORalpha1 AREB6 PPAR-alpha ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCTD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.2KCTD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P073029: view genomic region
(about GC identifiers)
Start:
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73,028,670 bp from pter |
End:
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73,061,984 bp from pter |
Size:
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33,315 bases |
Orientation:
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plus strand |
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Proteins
for KCTD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KCTD2_HUMAN, Q14681 (See
protein sequence)Recommended Name: BTB/POZ domain-containing protein KCTD2 Size: 263 amino acids; 28527 Da
Sequence caution: Sequence=BAA11493.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Explore the universe of human proteins at neXtProt for KCTD2: NX_Q14681
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14681
KCTD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056168.1
ENSEMBL proteins: ENSP00000464630 ENSP00000364435 ENSP00000312814
Human Recombinant Protein Products:
KCTD2 Antibody Products:
Assay Products for KCTD2: |
Protein
Domains /
Families
for KCTD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCTD2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14681ProtoNet protein and cluster: Q14681 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: KCTD2_HUMAN, Q14681Similarity: Contains 1 BTB (POZ) domain |
Function
for KCTD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KCTD2 (NM_015353) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCTD2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD2 |
|
Pathways & Interactions
for KCTD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sweet Taste Signaling | | | 2 | Activation of cAMP-Dependent PKA | | | 3 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | | | 4 | Hepatic ABC Transporters | |
5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCTD2 (see all 13)
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCTD2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/10 Interacting proteins for KCTD2 (Q146813 ENSP000003128144) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051260 | protein homooligomerization |
IEA | -- |
KCTD2 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCTD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KCTD2
Search CenterWatch for drugs/clinical trials and news about KCTD2
|
Transcripts
for KCTD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KCTD2 gene: NM_015353.1 Unigene Cluster for KCTD2: Potassium channel tetramerisation domain containing 2 Hs.514468 [show with all ESTs]Unigene Representative Sequence: NM_0153539 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000579242 ENST00000582840 ENST00000584767(uc010dfy.1) ENST00000584570
ENST00000581589 ENST00000375286(uc010dfz.3 uc002jmq.3) ENST00000322444(uc002jmp.3)
ENST00000577516 ENST00000579230
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KCTD2 (NM_015353) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCTD2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD2 |
Additional cDNA sequence: AF055014.1 AK307083.1 AK310690.1 AK311278.1 BC009633.1 BC033329.1 BC047910.1 BC072404.1 BC080561.1 D79998.1 12 DOTS entries: DT.91945742 DT.100840834 DT.444915 DT.102838146 DT.95275790 DT.40263079 DT.121003634 DT.121003637 DT.75103828 DT.95275789 DT.97824536 DT.121003642 24/191 AceView cDNA sequences (see all 191): BM809922 BE887054 AA429851 BQ932238 AA351667 BU624679 CA388985 CD742648 AF055014 AW303459 AW197904 AA321775 BM701319 CD369080 BQ773078 BE312145 AA810248 AI304883 AI168196 BM674292 AL044791 BC072404 AA861704 AI369784
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for KCTD2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 |
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| SP1: | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KCTD2
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Expression
for KCTD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KCTD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAATGAGGT
About this image
See KCTD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCTD2
SOURCE GeneReport for Unigene cluster: Hs.514468
SABiosciences Custom PCR Arrays for KCTD2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCTD2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCTD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD2 |
Orthologs
for KCTD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KCTD2 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for KCTD2 (if available)
TreeFam Gene Tree for KCTD2 (if available) |
Paralogs
for KCTD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KCTD2 gene
- KCTD172 KCTD52 KCTD92
2 SIMAP similar genes for KCTD2 using alignment to 4 protein entries: KCTD2_HUMAN (see all proteins):KCTD5 KCTD17
KCTD2 for paralogs About GeneDecksing
|
Genomic Variants
for KCTD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KCTD2 (73028670 - 73061984 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KCTD2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCTD2 |
|
Disorders
/ Diseases
for KCTD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 KCTD2 for disorders About MalaCards
KCTD2 for disorders About GeneDecksing
OMIM gene information: 613422
OMIM disorders: --
Export disorders for KCTD2 gene to outside databases
|
Publications
for KCTD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KCTD2 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with KCTD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Radiation hybrid map, physical map, and low-pass genomic sequence of the canine prcd region on CFA9 and comparative mapping with the syntenic region on human chromosome 17. (PubMed id 12620391)1, 3 Sidjanin D.J....Aguirre G. (2003)
- Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)1, 2 Nagase T.... Nomura N. (1996)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Whole genome association scan for genetic polymorphis ms influencing information processing speed. (PubMed id 21130836)1 Luciano M....Deary I.J. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
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External Searches for KCTD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCTD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCTD2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KCTD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KCTD2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KCTD2 gene:
Search GeneIP for patents involving KCTD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCTD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCTD2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCTD2 | | | OriGene Protein Over-expression Lysate for KCTD2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for KCTD2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KCTD2 | | OriGene Custom Protein Services for KCTD2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCTD2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCTD2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCTD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD2 |
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| | | | Search Tocris compounds for KCTD2 |
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 | | | KCTD2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD2 |
|  |  |  | | | | Search ThermoFisher Antibodies for KCTD2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD2 |
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