Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KCTD2 Gene

Aliases for KCTD2 Gene

  • Potassium Channel Tetramerization Domain Containing 2 2 3 5
  • Potassium Channel Tetramerization Domain-Containing Protein 2 4
  • Potassium Channel Tetramerisation Domain Containing 2 2
  • KIAA0176 4

External Ids for KCTD2 Gene

Previous GeneCards Identifiers for KCTD2 Gene

  • GC17P073508
  • GC17P073640
  • GC17P070554
  • GC17P073043
  • GC17P068453
  • GC17P073029
  • GC17P073034
  • GC17P073051

Summaries for KCTD2 Gene

GeneCards Summary for KCTD2 Gene

KCTD2 (Potassium Channel Tetramerization Domain Containing 2) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Sweet Taste Signaling. GO annotations related to this gene include protein complex binding. An important paralog of this gene is KCTD5.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD2 Gene

Genomics for KCTD2 Gene

Regulatory Elements for KCTD2 Gene

Enhancers for KCTD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G075010 1.8 FANTOM5 ENCODE dbSUPER 15.4 -20.4 -20365 3.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 HID1 KCTD2 CDR2L FADS6 ATP5H MRPL58 RAB37 GRIN2C ARMC7 SUMO2
GH17G075507 2 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +481.0 480982 11.8 MLX CREB3L1 ZFP64 DMAP1 SLC30A9 ZNF143 ZNF548 SP3 NFYC SSRP1 TSEN54 LLGL2 NUP85 TMEM94 NT5C UNK KCTD2 SUMO2 ENSG00000266980 TRIM65
GH17G074511 2 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -519.0 -518964 3.3 HDGF PKNOX1 ARNT SIN3A YBX1 FEZF1 ZNF2 ZNF302 CBX5 ZNF416 NAT9 NT5C NUP85 RN7SL573P CD300E HID1-AS1 CD300A MGC16275 KCTD2 CD300C
GH17G076026 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +995.6 995623 4.4 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 NT5C NUP85 UNK ENSG00000266980 CDK3 TEN1 METTL23 MYO15B KCTD2 MFSD11
GH17G075123 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +92.4 92374 2.9 HDGF PKNOX1 ARNT SIN3A YY1 ZNF766 CBX5 FOS ZHX2 JUNB NUP85 JPT1 NT5C SUMO2 ATP5H KCTD2 MRPL58 MRPS7 TSEN54 SLC16A5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCTD2 on UCSC Golden Path with GeneCards custom track

Promoters for KCTD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098305 1533 3001 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263

Genomic Location for KCTD2 Gene

Chromosome:
17
Start:
75,032,567 bp from pter
End:
75,065,889 bp from pter
Size:
33,323 bases
Orientation:
Plus strand

Genomic View for KCTD2 Gene

Genes around KCTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD2 Gene

Proteins for KCTD2 Gene

  • Protein details for KCTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14681-KCTD2_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein KCTD2
    Protein Accession:
    Q14681

    Protein attributes for KCTD2 Gene

    Size:
    263 amino acids
    Molecular mass:
    28527 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA11493.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for KCTD2 Gene

Post-translational modifications for KCTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD2 Gene

No data available for DME Specific Peptides for KCTD2 Gene

Domains & Families for KCTD2 Gene

Protein Domains for KCTD2 Gene

Suggested Antigen Peptide Sequences for KCTD2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KCTD2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KCTD2 Gene

Function for KCTD2 Gene

Gene Ontology (GO) - Molecular Function for KCTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032403 protein complex binding IDA 23209302
GO:0097602 cullin family protein binding IBA --
genes like me logo Genes that share ontologies with KCTD2: view
genes like me logo Genes that share phenotypes with KCTD2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD2 Gene

Localization for KCTD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD2 gene
Compartment Confidence
cytoskeleton 2
nucleus 2
plasma membrane 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KCTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KCTD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KCTD2 Gene

Pathways & Interactions for KCTD2 Gene

genes like me logo Genes that share pathways with KCTD2: view

Gene Ontology (GO) - Biological Process for KCTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD2: view

No data available for SIGNOR curated interactions for KCTD2 Gene

Drugs & Compounds for KCTD2 Gene

No Compound Related Data Available

Transcripts for KCTD2 Gene

Unigene Clusters for KCTD2 Gene

Potassium channel tetramerisation domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2:

Relevant External Links for KCTD2 Gene

GeneLoc Exon Structure for
KCTD2
ECgene alternative splicing isoforms for
KCTD2

Expression for KCTD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCTD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCTD2 Gene

This gene is overexpressed in Brain - Cerebellum (x4.6) and Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for KCTD2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (48.6) and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KCTD2 Gene



Protein tissue co-expression partners for KCTD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCTD2 Gene:

KCTD2

SOURCE GeneReport for Unigene cluster for KCTD2 Gene:

Hs.514468

Evidence on tissue expression from TISSUES for KCTD2 Gene

  • Bone marrow(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with KCTD2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCTD2 Gene

Orthologs for KCTD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD2 34 35
  • 99.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KCTD2 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCTD2 34 35
  • 92.37 (n)
dog
(Canis familiaris)
Mammalia KCTD2 34 35
  • 91.63 (n)
mouse
(Mus musculus)
Mammalia Kctd2 34 16 35
  • 90.11 (n)
oppossum
(Monodelphis domestica)
Mammalia KCTD2 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCTD2 34 35
  • 83.85 (n)
lizard
(Anolis carolinensis)
Reptilia KCTD2 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd2 34
  • 75.15 (n)
zebrafish
(Danio rerio)
Actinopterygii kctd2 34 35
  • 78.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta inc 35
  • 57 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-303 34
  • 57.69 (n)
inso-1 35
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8310 35
  • 65 (a)
OneToMany
Species where no ortholog for KCTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD2 Gene

ENSEMBL:
Gene Tree for KCTD2 (if available)
TreeFam:
Gene Tree for KCTD2 (if available)

Paralogs for KCTD2 Gene

Paralogs for KCTD2 Gene

(2) SIMAP similar genes for KCTD2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with KCTD2: view

Variants for KCTD2 Gene

Sequence variations from dbSNP and Humsavar for KCTD2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000112682 -- 75,051,978(+) ATCCT(A/G)TTAAG intron-variant
rs1000115515 -- 75,033,624(+) TCCTC(C/G)AAACC intron-variant
rs1000204754 -- 75,043,094(+) GCCCG(C/T)GCCAT intron-variant
rs1000353180 -- 75,062,564(+) ATTTT(A/G)ATTTA intron-variant
rs1000438449 -- 75,057,370(+) ATACC(C/T)GGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD2 Gene

Variant ID Type Subtype PubMed ID
esv1720628 CNV deletion 17803354
esv2566082 CNV deletion 19546169
esv2716235 CNV deletion 23290073
esv3554781 CNV deletion 23714750
esv3641253 CNV gain 21293372
esv3641254 CNV loss 21293372
esv3893044 CNV loss 25118596
nsv112456 CNV deletion 16902084

Variation tolerance for KCTD2 Gene

Residual Variation Intolerance Score: 25.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.27; 85.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCTD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD2 Gene

Disorders for KCTD2 Gene

Relevant External Links for KCTD2

Genetic Association Database (GAD)
KCTD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCTD2

No disorders were found for KCTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD2 Gene

Publications for KCTD2 Gene

  1. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M. … Deary I.J. (Biol Psychol 2011) 3 46 64
  2. Radiation hybrid map, physical map, and low-pass genomic sequence of the canine prcd region on CFA9 and comparative mapping with the syntenic region on human chromosome 17. (PMID: 12620391) Sidjanin D.J. … Aguirre G. (Genomics 2003) 2 3 64
  3. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 3 4 64
  4. KCTD2, an adaptor of Cullin3 E3 ubiquitin ligase, suppresses gliomagenesis by destabilizing c-Myc. (PMID: 28060381) Kim E.J. … Kim H. (Cell Death Differ. 2017) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for KCTD2 Gene

Sources for KCTD2 Gene

Content
Loading form....