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Aliases for KCTD19 Gene

Aliases for KCTD19 Gene

  • Potassium Channel Tetramerization Domain Containing 19 2 3 5
  • Potassium Channel Tetramerisation Domain Containing 19 2

External Ids for KCTD19 Gene

Previous GeneCards Identifiers for KCTD19 Gene

  • GC16M065881
  • GC16U900651
  • GC16M067323
  • GC16M053196

Summaries for KCTD19 Gene

GeneCards Summary for KCTD19 Gene

KCTD19 (Potassium Channel Tetramerization Domain Containing 19) is a Protein Coding gene. Diseases associated with KCTD19 include Cerebral Visual Impairment.

Additional gene information for KCTD19 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD19 Gene

Genomics for KCTD19 Gene

Regulatory Elements for KCTD19 Gene

Promoters for KCTD19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087104 -137 601 HDGF ARNT ARID4B ZNF2 SLC30A9 GTF3C2 GLIS2 ZNF143 ZNF202 SP3

Genomic Locations for KCTD19 Gene

Genomic Locations for KCTD19 Gene
37,336 bases
Minus strand

Genomic View for KCTD19 Gene

Genes around KCTD19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD19 Gene

Proteins for KCTD19 Gene

  • Protein details for KCTD19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD19
    Protein Accession:
    Secondary Accessions:
    • B4DZ49
    • Q8N804

    Protein attributes for KCTD19 Gene

    926 amino acids
    Molecular mass:
    104938 Da
    Quaternary structure:
    • Identified in a complex with ZNF541, HDAC1 and HSPA2.

neXtProt entry for KCTD19 Gene

Post-translational modifications for KCTD19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD19 Gene

No data available for DME Specific Peptides for KCTD19 Gene

Domains & Families for KCTD19 Gene

Gene Families for KCTD19 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KCTD19 Gene


Suggested Antigen Peptide Sequences for KCTD19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KCTD19: view

No data available for UniProtKB/Swiss-Prot for KCTD19 Gene

Function for KCTD19 Gene

Phenotypes From GWAS Catalog for KCTD19 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KCTD19 Gene

Localization for KCTD19 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD19 gene
Compartment Confidence
nucleus 3
cytosol 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for KCTD19 Gene

Pathways & Interactions for KCTD19 Gene

SuperPathways for KCTD19 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KCTD19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD19: view

No data available for Pathways by source and SIGNOR curated interactions for KCTD19 Gene

Drugs & Compounds for KCTD19 Gene

No Compound Related Data Available

Transcripts for KCTD19 Gene

Unigene Clusters for KCTD19 Gene

Potassium channel tetramerisation domain containing 19:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD19 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^
SP1: - - - - - - - -
SP2: - - -
SP3: - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - -
SP8: -
SP9: -

ExUns: 15a · 15b

Relevant External Links for KCTD19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCTD19 Gene

mRNA differential expression in normal tissues according to GTEx for KCTD19 Gene

This gene is overexpressed in Testis (x47.0).

Protein differential expression in normal tissues from HIPED for KCTD19 Gene

This gene is overexpressed in Plasma (63.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCTD19 Gene

Protein tissue co-expression partners for KCTD19 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KCTD19 Gene:


SOURCE GeneReport for Unigene cluster for KCTD19 Gene:

genes like me logo Genes that share expression patterns with KCTD19: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCTD19 Gene

Orthologs for KCTD19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCTD19 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KCTD19 33 34
  • 99.6 (n)
(Canis familiaris)
Mammalia KCTD19 33 34
  • 89.97 (n)
(Bos Taurus)
Mammalia KCTD19 33 34
  • 88.94 (n)
(Rattus norvegicus)
Mammalia Kctd19 33
  • 86.88 (n)
(Mus musculus)
Mammalia Kctd19 33 16 34
  • 86.63 (n)
(Monodelphis domestica)
Mammalia KCTD19 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 58 (a)
-- 34
  • 52 (a)
-- 34
  • 50 (a)
(Gallus gallus)
Aves KCTD19 33 34
  • 63.87 (n)
(Anolis carolinensis)
Reptilia KCTD19 34
  • 48 (a)
Species where no ortholog for KCTD19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KCTD19 Gene

Gene Tree for KCTD19 (if available)
Gene Tree for KCTD19 (if available)

Paralogs for KCTD19 Gene

(5) SIMAP similar genes for KCTD19 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KCTD19: view

No data available for Paralogs for KCTD19 Gene

Variants for KCTD19 Gene

Sequence variations from dbSNP and Humsavar for KCTD19 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs869312866 Likely pathogenic 67,320,674(-) CTACA(A/C)CTCCA reference, missense
rs1000129864 -- 67,289,884(+) AAGAC(C/T)GGAGG intron-variant, downstream-variant-500B
rs1000217128 -- 67,299,927(+) AAGAA(C/T)GGCAA intron-variant
rs1000297597 -- 67,324,985(+) CAAAT(C/G)GAGTG intron-variant, upstream-variant-2KB
rs1000314267 -- 67,303,931(+) ATTCA(C/T)TTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD19 Gene

Variant ID Type Subtype PubMed ID
nsv572906 CNV loss 21841781
nsv524492 CNV loss 19592680
nsv524363 CNV loss 19592680
nsv522852 CNV gain 19592680
nsv471092 CNV gain 18288195
esv3638883 CNV loss 21293372

Variation tolerance for KCTD19 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.28; 70.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD19 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD19 Gene

Disorders for KCTD19 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KCTD19 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
cerebral visual impairment
  • cortical visual impairment
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KCTD19

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KCTD19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCTD19 Gene

Publications for KCTD19 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Novel genetic causes for cerebral visual impairment. (PMID: 26350515) Bosch DG … de Vries BB (European journal of human genetics : EJHG 2016) 3 60
  3. A Genome-Wide Screen for Machinery Involved in Downregulation of MHC Class I by HIV-1 Nef. (PMID: 26466362) Choma MK … Robinson MS (PloS one 2015) 3 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for KCTD19 Gene

Sources for KCTD19 Gene

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