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Aliases for KCTD18 Gene

Aliases for KCTD18 Gene

  • Potassium Channel Tetramerization Domain Containing 18 2 3 5
  • Potassium Channel Tetramerisation Domain Containing 18 2 3
  • BTB/POZ Domain-Containing Protein KCTD18 3
  • 6530404F10Rik 3

External Ids for KCTD18 Gene

Previous GeneCards Identifiers for KCTD18 Gene

  • GC02M201180
  • GC02M201061
  • GC02M201353
  • GC02M193206

Summaries for KCTD18 Gene

GeneCards Summary for KCTD18 Gene

KCTD18 (Potassium Channel Tetramerization Domain Containing 18) is a Protein Coding gene.

Additional gene information for KCTD18 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD18 Gene

Genomics for KCTD18 Gene

Regulatory Elements for KCTD18 Gene

Enhancers for KCTD18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H201114 1.9 FANTOM5 ENCODE dbSUPER 20.8 -604.4 -604432 19 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MEF2D SSRP1 ZNF610 PPIL3 ORC2 CLK1 CDK15 CFLAR CASP10 KCTD18 FZD7 CFLAR-AS1 FAM126B
GH02H199953 1.1 ENCODE 23.5 +564.4 564409 3 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 LOC101927687 CLK1 KCTD18 TYW5 SPATS2L FTCDNL1 MAIP1
GH02H201070 1.2 ENCODE 15 -552.1 -552076 2 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 ZC3H11A NFYC MEF2D ORC2 CLK1 CDK15 KCTD18 CFLAR-AS1 MPP4 ENSG00000273209 SPATS2L TMEM237 PPIL3
GH02H200962 1.5 FANTOM5 ENCODE 10.6 -444.0 -444023 2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 PPIL3 ORC2 CDK15 KCTD18 SGO2 CLK1 CASP8 FAM126B NIF3L1 CFLAR
GH02H200063 0.7 ENCODE 10.3 +454.6 454556 3 SOX6 NFRKB IRF5 TRIM22 PLRG1 TCF12 LCORL POLR2A HDAC2 IKZF1 LOC101927687 PPIL3 KCTD18 TYW5 LOC105373833
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCTD18 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCTD18 Gene

Chromosome:
2
Start:
200,488,952 bp from pter
End:
200,519,784 bp from pter
Size:
30,833 bases
Orientation:
Minus strand

Genomic View for KCTD18 Gene

Genes around KCTD18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD18 Gene

Proteins for KCTD18 Gene

  • Protein details for KCTD18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PI47-KCD18_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein KCTD18
    Protein Accession:
    Q6PI47
    Secondary Accessions:
    • Q53T21
    • Q6NW26
    • Q6PCD8
    • Q8N9B7
    • Q96N73

    Protein attributes for KCTD18 Gene

    Size:
    426 amino acids
    Molecular mass:
    46739 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KCTD18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCTD18 Gene

Post-translational modifications for KCTD18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD18 Gene

No data available for DME Specific Peptides for KCTD18 Gene

Domains & Families for KCTD18 Gene

Gene Families for KCTD18 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KCTD18 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KCTD18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KCTD18: view

No data available for UniProtKB/Swiss-Prot for KCTD18 Gene

Function for KCTD18 Gene

Phenotypes From GWAS Catalog for KCTD18 Gene

genes like me logo Genes that share phenotypes with KCTD18: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KCTD18
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KCTD18 Gene

Localization for KCTD18 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD18 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD18 Gene

Pathways & Interactions for KCTD18 Gene

SuperPathways for KCTD18 Gene

No Data Available

Interacting Proteins for KCTD18 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000352941%0d%0a9606.ENSP00000008391%0d%0a9606.ENSP00000362332%0d%0a9606.ENSP00000201031%0d%0a9606.ENSP00000368924%0d%0a9606.ENSP00000377265%0d%0a
Selected Interacting proteins: ENSP00000352941 Q6PI47-KCD18_HUMAN for KCTD18 Gene via STRING IID

Gene Ontology (GO) - Biological Process for KCTD18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD18: view

No data available for Pathways by source and SIGNOR curated interactions for KCTD18 Gene

Drugs & Compounds for KCTD18 Gene

No Compound Related Data Available

Transcripts for KCTD18 Gene

Unigene Clusters for KCTD18 Gene

Potassium channel tetramerisation domain containing 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KCTD18
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD18 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2:

Relevant External Links for KCTD18 Gene

GeneLoc Exon Structure for
KCTD18
ECgene alternative splicing isoforms for
KCTD18

Expression for KCTD18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCTD18 Gene

Protein differential expression in normal tissues from HIPED for KCTD18 Gene

This gene is overexpressed in CD4 Tcells (47.3) and Pancreatic juice (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KCTD18 Gene



Protein tissue co-expression partners for KCTD18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KCTD18 Gene:

KCTD18

SOURCE GeneReport for Unigene cluster for KCTD18 Gene:

Hs.605775

Evidence on tissue expression from TISSUES for KCTD18 Gene

  • Nervous system(4.4)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with KCTD18: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCTD18 Gene

Orthologs for KCTD18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCTD18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD18 33 34
  • 99.45 (n)
rat
(Rattus norvegicus)
Mammalia Kctd18 33
  • 84.38 (n)
mouse
(Mus musculus)
Mammalia Kctd18 33 16 34
  • 83.98 (n)
cow
(Bos Taurus)
Mammalia KCTD18 33 34
  • 83.65 (n)
dog
(Canis familiaris)
Mammalia KCTD18 33 34
  • 80.19 (n)
oppossum
(Monodelphis domestica)
Mammalia KCTD18 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCTD18 33 34
  • 67.05 (n)
lizard
(Anolis carolinensis)
Reptilia KCTD18 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494936 33
  • 62.83 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32838 33
Species where no ortholog for KCTD18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KCTD18 Gene

ENSEMBL:
Gene Tree for KCTD18 (if available)
TreeFam:
Gene Tree for KCTD18 (if available)

Paralogs for KCTD18 Gene

No data available for Paralogs for KCTD18 Gene

Variants for KCTD18 Gene

Sequence variations from dbSNP and Humsavar for KCTD18 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000010238 -- 200,496,621(+) TCTCA(A/G)GTAGC intron-variant
rs1000061023 -- 200,496,974(+) TTTTA(C/T)CCATT intron-variant
rs1000191005 -- 200,491,894(+) GTTAT(C/T)TGAAA intron-variant
rs1000241605 -- 200,505,359(+) CACAC(G/T)CTGCT intron-variant
rs1000249403 -- 200,496,279(+) AGAGA(A/G)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD18 Gene

Variant ID Type Subtype PubMed ID
nsv474056 CNV novel sequence insertion 20440878

Variation tolerance for KCTD18 Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.33; 70.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD18 Gene

Human Gene Mutation Database (HGMD)
KCTD18
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCTD18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD18 Gene

Disorders for KCTD18 Gene

Relevant External Links for KCTD18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCTD18

No disorders were found for KCTD18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD18 Gene

Publications for KCTD18 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Fine-mapping of restless legs locus 4 (RLS4) identifies a haplotype over the SPATS2L and KCTD18 genes. (PMID: 23054586) Pichler I … Pramstaller PP (Journal of molecular neuroscience : MN 2013) 3 60

Products for KCTD18 Gene

Sources for KCTD18 Gene

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