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Aliases for KCTD18 Gene

Aliases for KCTD18 Gene

  • Potassium Channel Tetramerization Domain Containing 18 2 3 5
  • Potassium Channel Tetramerisation Domain Containing 18 2 3
  • BTB/POZ Domain-Containing Protein KCTD18 3
  • 6530404F10Rik 3

External Ids for KCTD18 Gene

Previous GeneCards Identifiers for KCTD18 Gene

  • GC02M201180
  • GC02M201061
  • GC02M201353
  • GC02M193206

Summaries for KCTD18 Gene

GeneCards Summary for KCTD18 Gene

KCTD18 (Potassium Channel Tetramerization Domain Containing 18) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD18 Gene

Genomics for KCTD18 Gene

Regulatory Elements for KCTD18 Gene

Enhancers for KCTD18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F201154 1.3 Ensembl ENCODE 15 -637.4 -637401 5.0 HDGF ATF1 MLX SIN3A ARID4B DMAP1 SLC30A9 ELK1 GATA2 ZNF143 PPIL3 CASP10 KCTD18 LOC105373835 ORC2 SPATS2L CFLAR-AS1 GC02P201142
GH02F200887 1.2 ENCODE 15 -369.4 -369404 3.6 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 PPIL3 TYW5 ORC2 KCTD18 RNU6-762P SPATS2L LOC100420110 NIF3L1 RNU6-312P
GH02F201070 1.2 ENCODE 15 -552.1 -552076 2.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ORC2 KCTD18 CFLAR-AS1 ENSG00000273209 SPATS2L PPIL3 FAM126B RNU6-1206P
GH02F200402 1.7 FANTOM5 Ensembl ENCODE 10.4 +113.3 113252 8.2 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YBX1 ZNF207 FOS ZNF263 SPATS2L PPIL3 KCTD18 FTCDNL1 AOX3P CLK1 BZW1 RNY4P34 LOC101927741
GH02F199953 1.1 ENCODE 15 +564.4 564409 3.3 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 LOC101927687 KCTD18 TYW5 SPATS2L FTCDNL1 MAIP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCTD18 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCTD18 Gene

200,488,952 bp from pter
200,519,784 bp from pter
30,833 bases
Minus strand

Genomic View for KCTD18 Gene

Genes around KCTD18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD18 Gene

Proteins for KCTD18 Gene

  • Protein details for KCTD18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD18
    Protein Accession:
    Secondary Accessions:
    • Q53T21
    • Q6NW26
    • Q6PCD8
    • Q8N9B7
    • Q96N73

    Protein attributes for KCTD18 Gene

    426 amino acids
    Molecular mass:
    46739 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KCTD18 Gene


neXtProt entry for KCTD18 Gene

Post-translational modifications for KCTD18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD18 Gene

No data available for DME Specific Peptides for KCTD18 Gene

Domains & Families for KCTD18 Gene

Protein Domains for KCTD18 Gene


Suggested Antigen Peptide Sequences for KCTD18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD18: view

No data available for Gene Families for KCTD18 Gene

Function for KCTD18 Gene

genes like me logo Genes that share phenotypes with KCTD18: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KCTD18 Gene

Localization for KCTD18 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD18 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD18 Gene

Pathways & Interactions for KCTD18 Gene

SuperPathways for KCTD18 Gene

No Data Available

Interacting Proteins for KCTD18 Gene

Gene Ontology (GO) - Biological Process for KCTD18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD18: view

No data available for Pathways by source and SIGNOR curated interactions for KCTD18 Gene

Transcripts for KCTD18 Gene

Unigene Clusters for KCTD18 Gene

Potassium channel tetramerisation domain containing 18:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD18 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -

Relevant External Links for KCTD18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCTD18 Gene

Protein differential expression in normal tissues from HIPED for KCTD18 Gene

This gene is overexpressed in CD4 Tcells (47.3) and Pancreatic juice (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KCTD18 Gene

Protein tissue co-expression partners for KCTD18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KCTD18 Gene:


SOURCE GeneReport for Unigene cluster for KCTD18 Gene:

genes like me logo Genes that share expression patterns with KCTD18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KCTD18 Gene

Orthologs for KCTD18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCTD18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KCTD18 34 35
  • 99.45 (n)
(Rattus norvegicus)
Mammalia Kctd18 34
  • 84.38 (n)
(Mus musculus)
Mammalia Kctd18 34 16 35
  • 83.98 (n)
(Bos Taurus)
Mammalia KCTD18 34 35
  • 83.65 (n)
(Canis familiaris)
Mammalia KCTD18 34 35
  • 80.19 (n)
(Monodelphis domestica)
Mammalia KCTD18 35
  • 73 (a)
(Gallus gallus)
Aves KCTD18 34 35
  • 67.05 (n)
(Anolis carolinensis)
Reptilia KCTD18 35
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494936 34
  • 62.83 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32838 34
Species where no ortholog for KCTD18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KCTD18 Gene

Gene Tree for KCTD18 (if available)
Gene Tree for KCTD18 (if available)

Paralogs for KCTD18 Gene

No data available for Paralogs for KCTD18 Gene

Variants for KCTD18 Gene

Sequence variations from dbSNP and Humsavar for KCTD18 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10084263 -- 200,502,633(+) TCCTG(A/C)AGATA intron-variant
rs10203042 -- 200,490,143(+) CCAAG(A/G)CACGG reference, missense
rs10203154 -- 200,490,375(+) CGTGC(A/C)CACCA reference, missense
rs10497864 -- 200,490,810(+) TCTTA(A/G)TTTGA intron-variant
rs10931901 -- 200,491,829(+) GTGTC(A/G)TTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD18 Gene

Variant ID Type Subtype PubMed ID
nsv474056 CNV novel sequence insertion 20440878

Variation tolerance for KCTD18 Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.33; 70.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD18 Gene

Disorders for KCTD18 Gene

Relevant External Links for KCTD18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KCTD18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD18 Gene

Publications for KCTD18 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Fine-mapping of restless legs locus 4 (RLS4) identifies a haplotype over the SPATS2L and KCTD18 genes. (PMID: 23054586) Pichler I. … Pramstaller P.P. (J. Mol. Neurosci. 2013) 3 64
  5. Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3 64

Products for KCTD18 Gene

Sources for KCTD18 Gene

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