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Aliases for KCTD18 Gene

Aliases for KCTD18 Gene

  • Potassium Channel Tetramerization Domain Containing 18 2 3
  • Potassium Channel Tetramerisation Domain Containing 18 2 3
  • 6530404F10Rik 3

External Ids for KCTD18 Gene

Previous GeneCards Identifiers for KCTD18 Gene

  • GC02M201180
  • GC02M201061
  • GC02M201353
  • GC02M193206

Summaries for KCTD18 Gene

GeneCards Summary for KCTD18 Gene

KCTD18 (Potassium Channel Tetramerization Domain Containing 18) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD18 Gene

Genomics for KCTD18 Gene

Regulatory Elements for KCTD18 Gene

Genomic Location for KCTD18 Gene

200,488,952 bp from pter
200,519,784 bp from pter
30,833 bases
Minus strand

Genomic View for KCTD18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCTD18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD18 Gene

Proteins for KCTD18 Gene

  • Protein details for KCTD18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD18
    Protein Accession:
    Secondary Accessions:
    • Q53T21
    • Q6NW26
    • Q6PCD8
    • Q8N9B7
    • Q96N73

    Protein attributes for KCTD18 Gene

    426 amino acids
    Molecular mass:
    46739 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KCTD18 Gene


neXtProt entry for KCTD18 Gene

Proteomics data for KCTD18 Gene at MOPED

Post-translational modifications for KCTD18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCTD18 Gene

Domains & Families for KCTD18 Gene

Protein Domains for KCTD18 Gene


Suggested Antigen Peptide Sequences for KCTD18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD18: view

No data available for Gene Families for KCTD18 Gene

Function for KCTD18 Gene

genes like me logo Genes that share phenotypes with KCTD18: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KCTD18 Gene

Localization for KCTD18 Gene

Subcellular locations from

Jensen Localization Image for KCTD18 Gene COMPARTMENTS Subcellular localization image for KCTD18 gene
Compartment Confidence
mitochondrion 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD18 Gene

Pathways & Interactions for KCTD18 Gene

SuperPathways for KCTD18 Gene

No Data Available

Interacting Proteins for KCTD18 Gene

Gene Ontology (GO) - Biological Process for KCTD18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD18: view

No data available for Pathways by source and SIGNOR curated interactions for KCTD18 Gene

Drugs & Compounds for KCTD18 Gene

No Compound Related Data Available

Transcripts for KCTD18 Gene

Unigene Clusters for KCTD18 Gene

Potassium channel tetramerisation domain containing 18:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCTD18

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD18 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -

Relevant External Links for KCTD18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD18 Gene

mRNA expression in normal human tissues for KCTD18 Gene

Protein differential expression in normal tissues from HIPED for KCTD18 Gene

This gene is overexpressed in CD4 Tcells (47.3) and Pancreatic juice (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCTD18 Gene

SOURCE GeneReport for Unigene cluster for KCTD18 Gene Hs.605775

genes like me logo Genes that share expression patterns with KCTD18: view

Protein tissue co-expression partners for KCTD18 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KCTD18 Gene

Orthologs for KCTD18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCTD18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCTD18 35
  • 83.65 (n)
  • 82.62 (a)
KCTD18 36
  • 82 (a)
(Canis familiaris)
Mammalia KCTD18 35
  • 80.19 (n)
  • 81.4 (a)
KCTD18 36
  • 80 (a)
(Mus musculus)
Mammalia Kctd18 35
  • 83.98 (n)
  • 82.61 (a)
Kctd18 16
Kctd18 36
  • 80 (a)
(Pan troglodytes)
Mammalia KCTD18 35
  • 99.45 (n)
  • 99.06 (a)
KCTD18 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Kctd18 35
  • 84.38 (n)
  • 83.82 (a)
(Monodelphis domestica)
Mammalia KCTD18 36
  • 73 (a)
(Gallus gallus)
Aves KCTD18 35
  • 67.05 (n)
  • 65.03 (a)
KCTD18 36
  • 62 (a)
(Anolis carolinensis)
Reptilia KCTD18 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494936 35
  • 62.83 (n)
  • 58.6 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32838 35
Species with no ortholog for KCTD18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KCTD18 Gene

Gene Tree for KCTD18 (if available)
Gene Tree for KCTD18 (if available)

Paralogs for KCTD18 Gene

No data available for Paralogs for KCTD18 Gene

Variants for KCTD18 Gene

Sequence variations from dbSNP and Humsavar for KCTD18 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs713396 -- 200,492,512(-) TGAAA(C/T)GCGGA intron-variant
rs713397 -- 200,492,901(-) TGGGC(A/C)TGCTG intron-variant
rs713398 -- 200,492,841(-) ATAGT(A/G)AAAAA intron-variant
rs967725 -- 200,498,359(-) AATTC(A/T)CTTAG intron-variant
rs1469956 -- 200,498,058(-) AAAAA(A/G)AGATC intron-variant

Variation tolerance for KCTD18 Gene

Residual Variation Intolerance Score: 66.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.33; 70.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD18 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KCTD18 Gene

Disorders for KCTD18 Gene

Relevant External Links for KCTD18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KCTD18: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD18 Gene

Publications for KCTD18 Gene

  1. Fine-mapping of restless legs locus 4 (RLS4) identifies a haplotype over the SPATS2L and KCTD18 genes. (PMID: 23054586) Pichler I. … Pramstaller P.P. (J. Mol. Neurosci. 2013) 67
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 67
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for KCTD18 Gene

Sources for KCTD18 Gene

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