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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCTD17 Gene

protein-coding   GIFtS: 49
GCID: GC22P037447

Potassium Channel Tetramerization Domain Containing 17

(Previous name: potassium channel tetramerisation domain containing 17)
  Search for KCTD17
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Channel Tetramerization Domain Containing 171 2
Potassium Channel Tetramerisation Domain Containing 171
BTB/POZ Domain-Containing Protein KCTD172

External Ids:    HGNC: 257051   Entrez Gene: 797342   Ensembl: ENSG000001003797   UniProtKB: Q8N5Z53   

Export aliases for KCTD17 gene to outside databases

Previous GC identifers: GC22P035773 GC22P020413


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KCTD17 Gene: 
KCTD17 (potassium channel tetramerization domain containing 17) is a protein-coding gene. GO annotations related to this gene include identical protein binding. An important paralog of this gene is KCTD5.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCTD17 gene promoter:
         AML1a   NRSF form 1   Lmo2   STAT5A   Nkx2-5   NRSF form 2   Egr-2   CREB   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCTD17 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCTD17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.3   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q12.3

KCTD17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCTD17 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P037447:  view genomic region     (about GC identifiers)

Start:
37,447,779 bp from pter      End:
37,459,430 bp from pter
Size:
11,652 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCD17_HUMAN, Q8N5Z5 (See protein sequence)
Recommended Name: BTB/POZ domain-containing protein KCTD17  
Size: 321 amino acids; 35670 Da
Sequence caution: Sequence=AAH25403.1; Type=Miscellaneous discrepancy; Note=The sequence differs in the N-terminus
for unknown reasons; Sequence=AAH31038.1; Type=Erroneous initiation;
Secondary accessions: B0QYA9 B0QYB0 O95517
Alternative splicing: 2 isoforms:  Q8N5Z5-1   Q8N5Z5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KCTD17: NX_Q8N5Z5

Explore proteomics data for KCTD17 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N5Z5

  • KCTD17 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCTD17 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001269613.1  NP_001269614.1  NP_001269615.1  NP_078957.2  

    ENSEMBL proteins: 
     ENSP00000384391   ENSP00000385096   ENSP00000409116   ENSP00000409638   ENSP00000402434  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011333 BTB/POZ_fold
     IPR003131 T1-type_BTB
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q8N5Z5

    ProtoNet protein and cluster: Q8N5Z5

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: KCD17_HUMAN, Q8N5Z5
    Similarity: Contains 1 BTB (POZ) domain


    KCTD17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0042802identical protein binding IPI16189514
         
    KCTD17 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KCTD17:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KCTD17 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidKCTD17 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD17


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCTD17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/27 Interacting proteins for KCTD17 (Q8N5Z51, 2, 3 ENSP000003843914) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LNX1Q8TBB12, 3, ENSP000002639254MINT-67420 I2D: score=5 STRING: ENSP00000263925
    AQP1P299722, 3, ENSP000003111654MINT-67673 I2D: score=4 STRING: ENSP00000311165
    LRRC18Q8N4562, 3, ENSP000002981244MINT-68097 I2D: score=4 STRING: ENSP00000298124
    STK16O757162, 3, ENSP000003799644MINT-67548 I2D: score=4 STRING: ENSP00000379964
    PSMA1P257862, 3MINT-68033 I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051260protein homooligomerization IEA--

    KCTD17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KCTD17 (KCD17)

    Search CenterWatch for drugs/clinical trials and news about KCTD17 / KCD17

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KCTD17 gene (4 alternative transcripts): 
    NM_001282684.1  NM_001282685.1  NM_001282686.1  NM_024681.3  

    Unigene Cluster for KCTD17:

    Potassium channel tetramerisation domain containing 17
    Hs.517597  [show with all ESTs]
    Unigene Representative Sequence: BC031038
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000402077(uc011amv.2) ENST00000403888(uc010gxa.1 uc010gxb.3)
    ENST00000421900 ENST00000456470 ENST00000483389 ENST00000431531 ENST00000478231
    ENST00000462640
    miRNA
    Products:
         
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate KCTD17 (see all 17):
    hsa-let-7d hsa-miR-10b hsa-miR-202 hsa-miR-1224-3p hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidKCTD17 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of KCTD17 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD17
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD17

    Additional mRNA sequence: 

    AK022304.1 BC025403.1 BC031038.1 

    10 DOTS entries:

    DT.453546  DT.100779269  DT.95164594  DT.100693359  DT.100779270  DT.120640312  DT.120640337  DT.70103395 
    DT.99958859  DT.102825688 

    24/93 AceView cDNA sequences (see all 93):

    BM704762 BU584316 AI280998 AA811876 BU520784 AA278212 AK022304 BG152656 
    AI621047 CR596515 CA944754 BM693909 BF725886 BC009961 AI339700 AA382510 
    CA314786 NM_024681 CD632217 BF115811 W70265 BI193046 AA761637 BC025403 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KCTD17 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
    SP1:                    -     -                                   -           -     -                     
    SP2:                    -     -                                   -     -     -     -                     
    SP3:                    -     -                                   -                                       
    SP4:                    -     -                                   -     -     -     -     -               
    SP5:                    -     -                                                                           


    ECgene alternative splicing isoforms for KCTD17

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCTD17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATAAAACC
    KCTD17 Expression
    About this image


    See KCTD17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCTD17

    SOURCE GeneReport for Unigene cluster: Hs.517597
        SABiosciences Custom PCR Arrays for KCTD17
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KCTD17 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kctd171 , 5 potassium channel tetramerisation domain containing 17 less1, 5 85.08(n)1
    87(a)1
      15 (37.49 cM)5
    728441  NM_001081367.11  NP_001074836.21 
     784285645 
    chicken
    (Gallus gallus)
    Aves KCTD171 potassium channel tetramerisation domain containing 17 less 77.49(n)
    82.48(a)
      418047  XM_416282.3  XP_416282.3 
    lizard
    (Anolis carolinensis)
    Reptilia KCTD176
    Uncharacterized protein
    88(a)
    1 ↔ 1
    5(22693847-22708995)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5682671 BTB/POZ domain-containing protein KCTD17-like 69.12(n)
    72.35(a)
      568267  XM_691587.3  XP_696679.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta inc6
    insomniac
    53(a)
    1 → many
    X(1407092-1411653)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-3036
    Protein TAG-303
    38(a)
    1 → many
    X(1300149-1308135)


    ENSEMBL Gene Tree for KCTD17 (if available)
    TreeFam Gene Tree for KCTD17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCTD17 gene
    KCTD52  KCTD22  KCTD92  
    7 SIMAP similar genes for KCTD17 using alignment to 4 protein entries:     KCD17_HUMAN (see all proteins):
    KCTD5    KCTD2    SHKBP1    KCTD3    KCTD1    KCTD21
    KCTD10

    KCTD17 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/358 SNPs in KCTD17 are shown (see all 358)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs801658071,2
    C,F--37445804(+) AGCTGG/CAACTA 1 -- us2k11Minor allele frequency- C:0.50WA 2
    rs1838275061,2
    --37445831(+) TGCCCA/GGCTAA 1 -- us2k10--------
    rs96106391,2
    F--37445993(+) tttttA/Taaata 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1414527491,2
    --37446134(+) AAATAC/GAAAAA 1 -- us2k10--------
    rs121593251,2
    A--37446301(+) aaaaaG/Aagaga 1 -- us2k1 trp31Minor allele frequency- A:0.50CSA 2
    rs1160364631,2
    F--37446397(+) GCCTTG/AGCCTC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs121593041,2
    C,F--37446399(+) cttggC/Actccc 1 -- us2k12Minor allele frequency- A:0.50WA CSA 4
    rs1880057391,2
    C--37446521(+) ATCCCA/CTTTGG 1 -- us2k10--------
    rs734155221,2
    C,F--37446782(+) CAGGAC/ATGAAA 1 -- us2k13Minor allele frequency- A:0.20WA CSA 122
    rs8557971,2
    C,F,H--37446977(-) CACGTC/TCTCCC 1 -- us2k14Minor allele frequency- T:0.00NS EA 418

    HapMap Linkage Disequilibrium report for KCTD17 (37447779 - 37459430 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KCTD17:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv34015CNV Loss18971310
    dgv4960n71CNV Loss21882294
    nsv829203CNV Loss20364138
    nsv834187CNV Loss17160897
    nsv915015CNV Loss21882294
    nsv459882CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KCTD17
    DNA2.0 Custom Variant and Variant Library Synthesis for KCTD17

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KCTD17 for disorders           About MalaCards

    KCTD17 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KCTD17

    Export disorders for KCTD17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCTD17 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with KCTD17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    5. Quantitative study of the interactome of PKCz involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (2013)
    6. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    7. Seventy-five genetic loci influencing the human red bl ood cell. (PubMed id 23222517)1 van der Harst P....Chambers J.C. (2012)
    8. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
    9. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
    10. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79734 HGNC: 25705 AceView: FLJ12242 Ensembl:ENSG00000100379 euGenes: HUgn79734
    ECgene: KCTD17 H-InvDB: KCTD17

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCTD17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCTD17 gene:
    Search GeneIP for patents involving KCTD17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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