KCTD17 Gene
protein-coding GIFtS: 47
GCID: GC22P037447
|
|
potassium channel tetramerisation domain containing 17
| |
Aliases
for KCTD17 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Potassium Channel Tetramerisation Domain Containing 171 2 | | FLJ122421 | | BTB/POZ Domain-Containing Protein KCTD172 |
Export aliases for KCTD17 gene to outside databasesPrevious GC identifers: GC22P035773 GC22P020413 |
Summaries
for KCTD17 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KCTD17 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCTD17 gene promoter:
AML1a NRSF form 1 Lmo2 STAT5A Nkx2-5 NRSF form 2 Egr-2 CREB E2F-1 E2F
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCTD17
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD17 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q12.3 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q12.3KCTD17 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P037447: view genomic region
(about GC identifiers)
Start:
|
37,447,779 bp from pter |
End:
|
37,459,430 bp from pter |
Size:
|
11,652 bases |
Orientation:
|
plus strand |
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Proteins
for KCTD17 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KCD17_HUMAN, Q8N5Z5 (See
protein sequence)Recommended Name: BTB/POZ domain-containing protein KCTD17 Size: 321 amino acids; 35670 Da
Sequence caution: Sequence=AAH25403.1; Type=Miscellaneous discrepancy; Note=The sequence differs in the N-terminus forunknown reasons; Sequence=AAH31038.1; Type=Erroneous initiation;
Secondary accessions: B0QYA9 B0QYB0 O95517Alternative splicing: 2 isoforms: Q8N5Z5-1 Q8N5Z5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KCTD17: NX_Q8N5Z5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N5Z5
KCTD17 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_078957.2
ENSEMBL proteins: ENSP00000384391 ENSP00000385096 ENSP00000409116 ENSP00000409638 ENSP00000402434
Human Recombinant Protein Products:
KCTD17 Antibody Products:
Assay Products for KCTD17: |
Protein
Domains /
Families
for KCTD17 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCTD17 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N5Z5ProtoNet protein and cluster: Q8N5Z5 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: KCD17_HUMAN, Q8N5Z5Similarity: Contains 1 BTB (POZ) domain |
Function
for KCTD17 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD17 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD17 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: KCTD17 (NM_024681) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCTD17 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD17 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD17 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
KCTD17 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KCTD17:
|
Pathways & Interactions
for KCTD17 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCTD17
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/27 Interacting proteins for KCTD17 (Q8N5Z51, 2, 3 ENSP000003843914) via UniProtKB, MINT, STRING, and/or I2D (see all 27)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051260 | protein homooligomerization |
IEA | -- |
KCTD17 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCTD17 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KCTD17
Search CenterWatch for drugs/clinical trials and news about KCTD17 / KCD17
|
Transcripts
for KCTD17 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KCTD17 gene: NM_024681.2 Unigene Cluster for KCTD17: Potassium channel tetramerisation domain containing 17 Hs.517597 [show with all ESTs]Unigene Representative Sequence: BC0310388 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000402077(uc011amv.2) ENST00000403888(uc010gxa.1 uc010gxb.3)
ENST00000421900 ENST00000456470 ENST00000483389 ENST00000431531 ENST00000478231
ENST00000462640
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD17 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD17 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KCTD17 (NM_024681) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCTD17 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD17 |
Additional cDNA sequence: AK022304.1 BC025403.1 BC031038.1 10 DOTS entries: DT.453546 DT.100779269 DT.95164594 DT.100693359 DT.100779270 DT.120640312 DT.120640337 DT.70103395 DT.99958859 DT.102825688 24/93 AceView cDNA sequences (see all 93): BU520784 AA811876 BU584316 BM704762 CA944754 NM_024681 CA314786 BC009961 BG152656 AI621047 AI339700 BM693909 AA382510 CR596515 AK022304 BF725886 AA278212 AI280998 CB152700 BF115811 BU623014 BF568574 AI660370 BC025403
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KCTD17 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | | | - | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | |
| SP5: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KCTD17
|
Expression
for KCTD17 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KCTD17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATAAAACC
About this image
See KCTD17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCTD17
SOURCE GeneReport for Unigene cluster: Hs.517597
SABiosciences Custom PCR Arrays for KCTD17
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCTD17
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD17 |
Orthologs
for KCTD17 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KCTD17 gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
KCTD171 |
potassium channel tetramerisation domain containing 17 less |
77.49(n)
82.48(a) |
|
418047 XM_416282.3 XP_416282.3 |
lizard
(Anolis carolinensis) |
Reptilia |
KCTD176 |
-- |
88(a) |
1 ↔ 1 |
5(22693847-22708995) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5682671 |
BTB/POZ domain-containing protein KCTD17-like |
69.12(n)
72.35(a) |
|
568267 XM_691587.3 XP_696679.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
inc6 |
insomniac |
53(a) |
1 → many |
X(1407092-1411653) |
worm
(Caenorhabditis elegans) |
Secernentea |
tag-3036 |
Temporarily Assigned Gene name family member (tag-... |
38(a) |
1 → many |
X(1300144-1308130) |
ENSEMBL Gene Tree for KCTD17 (if available)
TreeFam Gene Tree for KCTD17 (if available) |
Paralogs
for KCTD17 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KCTD17 gene
- KCTD52 KCTD22 KCTD92
6 SIMAP similar genes for KCTD17 using alignment to 4 protein entries: KCD17_HUMAN (see all proteins):KCTD5 KCTD2 KCTD3 KCTD1 KCTD21 KCTD10
KCTD17 for paralogs About GeneDecksing
|
Genomic Variants
for KCTD17 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KCTD17 (37447779 - 37459430 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KCTD17
1 CNV: 47855 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCTD17 |
|
Disorders
/ Diseases
for KCTD17 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for KCTD17 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KCTD17 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KCTD17) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
|
External Searches for KCTD17 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCTD17 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCTD17 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCTD17 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KCTD17 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KCTD17 gene:
Search GeneIP for patents involving KCTD17
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCTD17 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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