Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KCTD16 Gene

Aliases for KCTD16 Gene

  • Potassium Channel Tetramerization Domain Containing 16 2 3 5
  • Potassium Channel Tetramerization Domain-Containing Protein 16 4
  • Potassium Channel Tetramerisation Domain Containing 16 2
  • KIAA1317 4

External Ids for KCTD16 Gene

Previous GeneCards Identifiers for KCTD16 Gene

  • GC05P143613
  • GC05P143565
  • GC05P138699

Summaries for KCTD16 Gene

GeneCards Summary for KCTD16 Gene

KCTD16 (Potassium Channel Tetramerization Domain Containing 16) is a Protein Coding gene. An important paralog of this gene is KCTD11.

UniProtKB/Swiss-Prot for KCTD16 Gene

  • Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD16 Gene

Genomics for KCTD16 Gene

Regulatory Elements for KCTD16 Gene

Enhancers for KCTD16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCTD16 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCTD16 Gene

144,170,760 bp from pter
144,485,686 bp from pter
314,927 bases
Plus strand

Genomic View for KCTD16 Gene

Genes around KCTD16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD16 Gene

Proteins for KCTD16 Gene

  • Protein details for KCTD16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD16
    Protein Accession:
    Secondary Accessions:
    • Q9P2M9

    Protein attributes for KCTD16 Gene

    428 amino acids
    Molecular mass:
    49138 Da
    Quaternary structure:
    • Interacts as a tetramer with GABRB1 and GABRB2.
    • Sequence=BAA92555.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KCTD16 Gene

neXtProt entry for KCTD16 Gene

Proteomics data for KCTD16 Gene at MOPED

Post-translational modifications for KCTD16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCTD16 Gene

Domains & Families for KCTD16 Gene

Protein Domains for KCTD16 Gene

Suggested Antigen Peptide Sequences for KCTD16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD16: view

No data available for Gene Families for KCTD16 Gene

Function for KCTD16 Gene

Molecular function for KCTD16 Gene

UniProtKB/Swiss-Prot Function:
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).
genes like me logo Genes that share phenotypes with KCTD16: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD16 Gene

Localization for KCTD16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCTD16 Gene

Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane.

Subcellular locations from

Jensen Localization Image for KCTD16 Gene COMPARTMENTS Subcellular localization image for KCTD16 gene
Compartment Confidence
nucleus 3
plasma membrane 3
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KCTD16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with KCTD16: view

Pathways & Interactions for KCTD16 Gene

SuperPathways for KCTD16 Gene

No Data Available

Interacting Proteins for KCTD16 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000424151 for KCTD16 Gene via STRING

Gene Ontology (GO) - Biological Process for KCTD16 Gene


No data available for Pathways by source and SIGNOR curated interactions for KCTD16 Gene

Drugs & Compounds for KCTD16 Gene

No Compound Related Data Available

Transcripts for KCTD16 Gene

mRNA/cDNA for KCTD16 Gene

(7) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCTD16 Gene

Potassium channel tetramerisation domain containing 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD16 Gene

No ASD Table

Relevant External Links for KCTD16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD16 Gene

mRNA expression in normal human tissues for KCTD16 Gene

mRNA differential expression in normal tissues according to GTEx for KCTD16 Gene

This gene is overexpressed in Brain - Cortex (x6.0), Brain - Frontal Cortex (BA9) (x5.8), and Brain - Anterior cingulate cortex (BA24) (x5.5).

Protein differential expression in normal tissues from HIPED for KCTD16 Gene

This gene is overexpressed in Brain (21.2), Fetal Brain (17.5), Frontal cortex (15.4), and Heart (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCTD16 Gene

SOURCE GeneReport for Unigene cluster for KCTD16 Gene Hs.661870

genes like me logo Genes that share expression patterns with KCTD16: view

Protein tissue co-expression partners for KCTD16 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for KCTD16 Gene

Orthologs for KCTD16 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCTD16 35
  • 93.77 (n)
  • 98.36 (a)
KCTD16 36
  • 93 (a)
(Canis familiaris)
Mammalia KCTD16 35
  • 93.15 (n)
  • 97.66 (a)
KCTD16 36
  • 88 (a)
(Mus musculus)
Mammalia Kctd16 35
  • 89.7 (n)
  • 96.49 (a)
Kctd16 16
Kctd16 36
  • 96 (a)
(Pan troglodytes)
Mammalia KCTD16 35
  • 99.84 (n)
  • 100 (a)
KCTD16 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Kctd16 35
  • 90.09 (n)
  • 96.49 (a)
(Monodelphis domestica)
Mammalia KCTD16 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia KCTD16 36
  • 87 (a)
(Gallus gallus)
Aves KCTD16 35
  • 81.3 (n)
  • 90.14 (a)
KCTD16 36
  • 89 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
-- 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd16 35
  • 78.33 (n)
  • 86.38 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13002 35
(Danio rerio)
Actinopterygii kctd16b 35
  • 70.18 (n)
  • 76.79 (a)
kctd16a 36
  • 67 (a)
kctd16b 36
  • 72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10830 36
  • 50 (a)
(Caenorhabditis elegans)
Secernentea VM106R.1 36
  • 37 (a)
Species with no ortholog for KCTD16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD16 Gene

Gene Tree for KCTD16 (if available)
Gene Tree for KCTD16 (if available)

Paralogs for KCTD16 Gene

Paralogs for KCTD16 Gene

(2) SIMAP similar genes for KCTD16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCTD16: view

Variants for KCTD16 Gene

Sequence variations from dbSNP and Humsavar for KCTD16 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs712163 -- 144,376,914(-) ATGAA(C/T)GGCAC intron-variant
rs712171 -- 144,471,280(-) TTCCC(C/T)ATGGT intron-variant
rs712173 -- 144,472,181(-) GATAA(C/T)GTAGT intron-variant
rs712174 -- 144,472,206(+) CATAA(A/G)GGAAT intron-variant
rs723223 -- 144,368,038(-) AATAA(C/T)GATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD16 Gene

Variant ID Type Subtype PubMed ID
nsv882997 CNV Gain 21882294
nsv5045 CNV Insertion 18451855
esv273840 CNV Insertion 20981092
esv2730867 CNV Deletion 23290073
esv2207447 CNV Deletion 18987734
nsv830513 CNV Gain 17160897
dgv1047e199 CNV Deletion 23128226
esv271239 CNV Insertion 20981092
nsv5046 CNV Insertion 18451855

Variation tolerance for KCTD16 Gene

Residual Variation Intolerance Score: 30.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KCTD16 Gene

Disorders for KCTD16 Gene

Relevant External Links for KCTD16

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KCTD16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD16 Gene

Publications for KCTD16 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. (PMID: 24529757) Xie T. … Xu R. (Neurobiol. Aging 2014) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for KCTD16 Gene

Sources for KCTD16 Gene