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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCTD16 Gene

protein-coding   GIFtS: 47
GCID: GC05P143565

Potassium Channel Tetramerization Domain Containing 16

(Previous name: potassium channel tetramerisation domain containing 16)
  Search for KCTD16
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Channel Tetramerization Domain Containing 161 2
Potassium Channel Tetramerisation Domain Containing 161 2
Potassium Channel Tetramerization Domain-Containing Protein 162 3
KIAA13173 5
BTB/POZ Domain-Containing Protein KCTD162

External Ids:    HGNC: 292441   Entrez Gene: 575282   Ensembl: ENSG000001837757   OMIM: 6134235   UniProtKB: Q68DU83   

Export aliases for KCTD16 gene to outside databases

Previous GC identifers: GC05P143613 GC05P138699


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KCTD16 Gene: 
KCTD16 (potassium channel tetramerization domain containing 16) is a protein-coding gene. An important paralog of this gene is KCTD1.

UniProtKB/Swiss-Prot: KCD16_HUMAN, Q68DU8
Function: Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor
response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating
onset and promoting desensitization (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_029289.11  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCTD16 gene promoter:
         RP58   Nkx2-5   GATA-1   HNF-1A   SRY   POU2F1   HNF-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCTD16 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCTD16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.3   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q32

KCTD16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCTD16 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P143565:  view genomic region     (about GC identifiers)

Start:
143,550,396 bp from pter      End:
143,856,945 bp from pter
Size:
306,550 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCD16_HUMAN, Q68DU8 (See protein sequence)
Recommended Name: BTB/POZ domain-containing protein KCTD16  
Size: 428 amino acids; 49138 Da
Subunit: Interacts as a tetramer with GABRB1 and GABRB2 (By similarity)
Subcellular location: Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell
membrane (By similarity)
Sequence caution: Sequence=BAA92555.1; Type=Erroneous initiation;
Secondary accessions: Q9P2M9

Explore the universe of human proteins at neXtProt for KCTD16: NX_Q68DU8

Explore proteomics data for KCTD16 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q68DU8

  • KCTD16 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCTD16 Protein Expression
    REFSEQ proteins: NP_065819.1  
    ENSEMBL proteins: 
     ENSP00000424151   ENSP00000426548  

    Human Recombinant Protein Products for KCTD16: 
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    Cloud-Clone Corp. Proteins for KCTD16 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0030054cell junction IEA--
    GO:0042734presynaptic membrane IEA--
    GO:0043235receptor complex IEA--
    GO:0045211postsynaptic membrane IEA--

    KCTD16 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: KCTD16 


    3 InterPro protein domains:
     IPR011333 BTB/POZ_fold
     IPR003131 T1-type_BTB
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q68DU8

    ProtoNet protein and cluster: Q68DU8

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: KCD16_HUMAN, Q68DU8
    Similarity: Contains 1 BTB (POZ) domain


    KCTD16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCD16_HUMAN, Q68DU8
    Function: Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor
    response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating
    onset and promoting desensitization (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    KCTD16 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KCTD16:
     Increased cell death HMECs cel 

    Animal Models:
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD16


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCTD16

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway IEA--
    GO:0051260protein homooligomerization IEA--

    KCTD16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KCTD16 (KCD16)

    Search CenterWatch for drugs/clinical trials and news about KCTD16 / KCD16

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KCTD16 gene: 
    NM_020768.3  

    Unigene Cluster for KCTD16:

    Potassium channel tetramerisation domain containing 16
    Hs.661870  [show with all ESTs]
    Unigene Representative Sequence: AB037738
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512467 ENST00000507359(uc003lnm.1 uc003lnn.1)
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD16
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD16

    Additional mRNA sequence: 

    AB037738.1 AK292477.1 BC111962.1 BC113435.1 CR749266.1 

    2 DOTS entries:

    DT.120808583  DT.40251046 

    4 AceView cDNA sequences:

    AA332022 CR749266 AB037738 AL120401 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCTD16 expression in normal human tissues (normalized intensities)      KCTD16 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCAGCAAAA
    KCTD16 Expression
    About this image


    KCTD16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Medulla Oblongata
             postcentral gyrus   
     
     Lung (Respiratory System)
             Trachea
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See KCTD16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCTD16

    SOURCE GeneReport for Unigene cluster: Hs.661870
        SABiosciences Custom PCR Arrays for KCTD16
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KCTD16 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kctd161 , 5 potassium channel tetramerisation domain containing more1, 5 89.7(n)1
    96.49(a)1
      18 (21.30 cM)5
    3833481  NM_026135.11  NP_080411.11 
     402583615 
    chicken
    (Gallus gallus)
    Aves KCTD161 potassium channel tetramerisation domain containing more 81.3(n)
    90.14(a)
      427644  XM_425217.2  XP_425217.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    KCTD166
    Uncharacterized protein
    90(a)
    83(a)
    many → 1
    many → 1
    GL343234.1(1807046-1807556)
    GL343234.1(2084281-2085552)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.130022 Xenopus laevis transcribed sequences 76.23(n)    BJ095666.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kctd16b1 potassium channel tetramerisation domain containing more 70.18(n)
    76.79(a)
      569756  NM_001128752.1  NP_001122224.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG108306
    --
    50(a)
    1 → many
    3R(16720174-16723042)
    worm
    (Caenorhabditis elegans)
    Secernentea VM106R.16
    Protein VM106R.1
    35(a)
    1 → many
    II(10827716-10829556)


    ENSEMBL Gene Tree for KCTD16 (if available)
    TreeFam Gene Tree for KCTD16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCTD16 gene
    KCTD12  KCTD82  KCTD152  KCTD42  KCTD112  KCNRG2  KCTD122  KCTD212  
    KCTD62  KCTD142  
    2 SIMAP similar genes for KCTD16 using alignment to 1 protein entry:     KCD16_HUMAN:
    KCTD8    KCTD12

    KCTD16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5493 SNPs in KCTD16 are shown (see all 5493)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1433567941,2
    Cuntested1143586716(+) GAAGCA/GACACA 2 N D mis10--------
    rs1829259391,2
    --143552306(+) CCTAAA/TTCAGT 1 -- int10--------
    rs1876209431,2
    --143552395(+) AATCCA/TTCATT 1 -- int10--------
    rs1415407981,2
    --143552484(+) AAAAAG/TGATAT 1 -- int10--------
    rs1926008031,2
    --143552577(+) GAATGC/TGTATA 1 -- int10--------
    rs1842529341,2
    --143552632(+) AGTGTG/TGCGAA 1 -- int10--------
    rs1896110561,2
    --143552725(+) CTATCA/GTAACT 1 -- int10--------
    rs750476881,2
    C,F--143552726(+) TACCAC/TGAAAA 1 -- int13Minor allele frequency- T:0.25NA 8
    rs1926902561,2
    --143552732(+) AACTAC/TGCATG 1 -- int10--------
    rs1145325661,2
    F--143552790(+) AGCAAC/TTTAAA 1 -- int11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for KCTD16 (143550396 - 143800396 bp, first 250kb of KCTD16)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for KCTD16:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1047e199CNV Deletion23128226
    esv2730867CNV Deletion23290073
    esv2207447CNV Deletion18987734
    nsv5046CNV Insertion18451855
    esv273840CNV Insertion20981092
    nsv5045CNV Insertion18451855
    esv271239CNV Insertion20981092
    nsv882997CNV Gain21882294
    nsv830513CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KCTD16 for disorders           About MalaCards
    OMIM gene information: 613423    OMIM disorders: --


    KCTD16 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KCTD16
    Human Genome Epidemiology (HuGE) Navigator: KCTD16 (1 document)

    Export disorders for KCTD16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCTD16 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KCTD16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57528 HGNC: 29244 AceView: KCTD16 Ensembl:ENSG00000183775 euGenes: HUgn57528
    ECgene: KCTD16 H-InvDB: KCTD16

    (According to HUGE)
    About This Section
    HUGE: KIAA1317

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCTD16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCTD16 gene:
    Search GeneIP for patents involving KCTD16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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