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Aliases for KCTD16 Gene

Aliases for KCTD16 Gene

  • Potassium Channel Tetramerization Domain Containing 16 2 3
  • KIAA1317 4 6
  • Potassium Channel Tetramerization Domain-Containing Protein 16 4
  • Potassium Channel Tetramerisation Domain Containing 16 2

External Ids for KCTD16 Gene

Previous GeneCards Identifiers for KCTD16 Gene

  • GC05P143613
  • GC05P143565
  • GC05P138699

Summaries for KCTD16 Gene

GeneCards Summary for KCTD16 Gene

KCTD16 (Potassium Channel Tetramerization Domain Containing 16) is a Protein Coding gene. An important paralog of this gene is KCTD11.

UniProtKB/Swiss-Prot for KCTD16 Gene

  • Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD16 Gene

Genomics for KCTD16 Gene

Regulatory Elements for KCTD16 Gene

Genomic Location for KCTD16 Gene

Start:
144,170,832 bp from pter
End:
144,485,686 bp from pter
Size:
314,855 bases
Orientation:
Plus strand

Genomic View for KCTD16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCTD16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD16 Gene

Proteins for KCTD16 Gene

  • Protein details for KCTD16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DU8-KCD16_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein KCTD16
    Protein Accession:
    Q68DU8
    Secondary Accessions:
    • Q9P2M9

    Protein attributes for KCTD16 Gene

    Size:
    428 amino acids
    Molecular mass:
    49138 Da
    Quaternary structure:
    • Interacts as a tetramer with GABRB1 and GABRB2.
    SequenceCaution:
    • Sequence=BAA92555.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KCTD16 Gene

Proteomics data for KCTD16 Gene at MOPED

Post-translational modifications for KCTD16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCTD16 Gene

Domains for KCTD16 Gene

Protein Domains for KCTD16 Gene

Suggested Antigen Peptide Sequences for KCTD16 Gene

Graphical View of Domain Structure for InterPro Entry

Q68DU8

UniProtKB/Swiss-Prot:

KCD16_HUMAN :
  • Q68DU8
Domain:
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD16: view

No data available for Gene Families for KCTD16 Gene

Function for KCTD16 Gene

Molecular function for KCTD16 Gene

UniProtKB/Swiss-Prot Function: Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).

Gene Ontology (GO) - Molecular Function for KCTD16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KCTD16: view

Phenotypes for KCTD16 Gene

GenomeRNAi human phenotypes for KCTD16:
genes like me logo Genes that share phenotypes with KCTD16: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCTD16

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCTD16 Gene

Localization for KCTD16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCTD16 Gene

Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCTD16 Gene COMPARTMENTS Subcellular localization image for KCTD16 gene
Compartment Confidence
nucleus 3
plasma membrane 3
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KCTD16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030054 cell junction IEA --
GO:0042734 presynaptic membrane IEA --
GO:0043235 receptor complex IEA --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with KCTD16: view

Pathways for KCTD16 Gene

SuperPathways for KCTD16 Gene

No Data Available

Interacting Proteins for KCTD16 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000424151%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000264414%0d%0a9606.ENSP00000384109%0d%0a
Selected Interacting proteins: ENSP00000424151 for KCTD16 Gene via STRING

Gene Ontology (GO) - Biological Process for KCTD16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD16: view

No data available for Pathways by source for KCTD16 Gene

Transcripts for KCTD16 Gene

mRNA/cDNA for KCTD16 Gene

(4) Selected AceView cDNA sequences:
(7) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCTD16 Gene

Potassium channel tetramerisation domain containing 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCTD16

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KCTD16

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD16 Gene

No ASD Table

Relevant External Links for KCTD16 Gene

GeneLoc Exon Structure for
KCTD16
ECgene alternative splicing isoforms for
KCTD16

Expression for KCTD16 Gene

mRNA expression in normal human tissues for KCTD16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCTD16 Gene

This gene is overexpressed in Brain - Cortex (6.0), Brain - Frontal Cortex (BA9) (5.8), and Brain - Anterior cingulate cortex (BA24) (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCTD16 Gene

SOURCE GeneReport for Unigene cluster for KCTD16 Gene Hs.661870

genes like me logo Genes that share expressions with KCTD16: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KCTD16 Gene

Orthologs for KCTD16 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD16 35
  • 99.84 (n)
  • 100 (a)
KCTD16 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCTD16 35
  • 93.77 (n)
  • 98.36 (a)
KCTD16 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCTD16 35
  • 93.15 (n)
  • 97.66 (a)
KCTD16 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kctd16 35
  • 89.7 (n)
  • 96.49 (a)
Kctd16 16
Kctd16 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCTD16 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCTD16 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kctd16 35
  • 90.09 (n)
  • 96.49 (a)
chicken
(Gallus gallus)
Aves KCTD16 35
  • 81.3 (n)
  • 90.14 (a)
KCTD16 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.13002 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd16 35
  • 78.33 (n)
  • 86.38 (a)
zebrafish
(Danio rerio)
Actinopterygii kctd16a 36
  • 67 (a)
OneToMany
kctd16b 35
  • 70.18 (n)
  • 76.79 (a)
kctd16b 36
  • 72 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10830 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea VM106R.1 36
  • 37 (a)
ManyToMany
Species with no ortholog for KCTD16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD16 Gene

ENSEMBL:
Gene Tree for KCTD16 (if available)
TreeFam:
Gene Tree for KCTD16 (if available)

Paralogs for KCTD16 Gene

Paralogs for KCTD16 Gene

Selected SIMAP similar genes for KCTD16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCTD16: view

Variants for KCTD16 Gene

Sequence variations from dbSNP and Humsavar for KCTD16 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs29889 -- 144,327,656(-) CATGT(A/G)TATAT intron-variant
rs29890 -- 144,328,038(-) TGTGA(A/T)GTTGT intron-variant
rs29891 -- 144,328,146(-) AGTAC(C/T)GTGTT intron-variant
rs29892 -- 144,328,214(-) GTTAA(A/C)ACAGG intron-variant
rs29893 -- 144,328,895(+) TTCTT(A/G)TTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD16 Gene

Variant ID Type Subtype PubMed ID
nsv882997 CNV Gain 21882294
nsv5045 CNV Insertion 18451855
esv273840 CNV Insertion 20981092
esv2730867 CNV Deletion 23290073
esv2207447 CNV Deletion 18987734
nsv830513 CNV Gain 17160897
dgv1047e199 CNV Deletion 23128226
esv271239 CNV Insertion 20981092
nsv5046 CNV Insertion 18451855

Relevant External Links for KCTD16 Gene

HapMap Linkage Disequilibrium report
KCTD16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD16 Gene

Disorders for KCTD16 Gene

Relevant External Links for KCTD16

Genetic Association Database (GAD)
KCTD16
Human Genome Epidemiology (HuGE) Navigator
KCTD16
genes like me logo Genes that share disorders with KCTD16: view

No data available for UniProtKB/Swiss-Prot for KCTD16 Gene

Publications for KCTD16 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PMID: 22053931) Oshikawa K. … Nakayama K.I. (J. Proteome Res. 2012) 3

Products for KCTD16 Gene

Sources for KCTD16 Gene

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