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Aliases for KCTD15 Gene

Aliases for KCTD15 Gene

  • Potassium Channel Tetramerization Domain Containing 15 2 3 5
  • Potassium Channel Tetramerization Domain-Containing Protein 15 4
  • Potassium Channel Tetramerisation Domain Containing 15 2

External Ids for KCTD15 Gene

Previous GeneCards Identifiers for KCTD15 Gene

  • GC19P038979
  • GC19P034287
  • GC19P030786

Summaries for KCTD15 Gene

GeneCards Summary for KCTD15 Gene

KCTD15 (Potassium Channel Tetramerization Domain Containing 15) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. An important paralog of this gene is KCTD1.

UniProtKB/Swiss-Prot for KCTD15 Gene

  • During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain.

Gene Wiki entry for KCTD15 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD15 Gene

Genomics for KCTD15 Gene

Regulatory Elements for KCTD15 Gene

Enhancers for KCTD15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F033818 1.7 FANTOM5 Ensembl ENCODE 19.4 +24.4 24389 3.4 ZFP64 ARID4B SIN3A FEZF1 YY1 ZNF302 ZNF416 KLF13 SP3 REST GPATCH1 LSM14A KIAA0355 FAAP24 WTIP KCTD15 ENSG00000271049 LOC105372372 PIR48101 GC19P033834
GH19F033815 0.7 Ensembl 18.3 +20.8 20768 1.8 KLF1 KLF17 DMAP1 ZFHX2 POLR2A PRDM10 FOS ZNF600 KLF13 EGR2 KCTD15 PIR48101 GC19P033834
GH19F033794 1.1 ENCODE 9.9 +1.3 1347 5.6 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 ZNF263 SP3 ZHX2 GPATCH1 LSM14A KIAA0355 RPL21P131 LOC100996681 AKR1B1P7 FAAP24 WDR88 KCTD15 PEPD
GH19F033767 0.8 ENCODE 12.4 -27.9 -27883 0.2 SOX13 ELF3 CTCF ZNF792 SAP130 ARID4B ZSCAN9 RAD21 HBP1 RARA KCTD15 GC19P033749
GH19F033768 0.7 FANTOM5 12.4 -26.9 -26854 0.2 ZNF362 ZNF76 ZFP37 FEZF1 ZNF501 ZIC2 ZNF335 GLIS1 PRDM10 KCTD15 GC19P033749
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCTD15 on UCSC Golden Path with GeneCards custom track

Promoters for KCTD15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000345691 967 4201 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 ZNF263 SP3 ZHX2

Genomic Location for KCTD15 Gene

Chromosome:
19
Start:
33,795,933 bp from pter
End:
33,815,763 bp from pter
Size:
19,831 bases
Orientation:
Plus strand

Genomic View for KCTD15 Gene

Genes around KCTD15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD15 Gene

Proteins for KCTD15 Gene

  • Protein details for KCTD15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SI1-KCD15_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein KCTD15
    Protein Accession:
    Q96SI1
    Secondary Accessions:
    • A8K600
    • Q9BVI6

    Protein attributes for KCTD15 Gene

    Size:
    283 amino acids
    Molecular mass:
    31942 Da
    Quaternary structure:
    • Interacts with TFAP2A; this interaction inhibits TFAP2A transcriptional activation.

    Alternative splice isoforms for KCTD15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCTD15 Gene

Post-translational modifications for KCTD15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KCTD15 Gene

Domains & Families for KCTD15 Gene

Protein Domains for KCTD15 Gene

Suggested Antigen Peptide Sequences for KCTD15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96SI1

UniProtKB/Swiss-Prot:

KCD15_HUMAN :
  • Contains 1 BTB (POZ) domain.
Domain:
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD15: view

No data available for Gene Families for KCTD15 Gene

Function for KCTD15 Gene

Molecular function for KCTD15 Gene

UniProtKB/Swiss-Prot Function:
During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain.

Gene Ontology (GO) - Molecular Function for KCTD15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KCTD15: view
genes like me logo Genes that share phenotypes with KCTD15: view

Animal Models for KCTD15 Gene

MGI Knock Outs for KCTD15:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCTD15

miRNA for KCTD15 Gene

miRTarBase miRNAs that target KCTD15

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCTD15 Gene

Localization for KCTD15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD15 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD15 Gene

Pathways & Interactions for KCTD15 Gene

genes like me logo Genes that share pathways with KCTD15: view

Gene Ontology (GO) - Biological Process for KCTD15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD15: view

No data available for SIGNOR curated interactions for KCTD15 Gene

Transcripts for KCTD15 Gene

Unigene Clusters for KCTD15 Gene

Potassium channel tetramerisation domain containing 15:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD15 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: - -
SP3: - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - - -
SP8: - - -
SP9: -

Relevant External Links for KCTD15 Gene

GeneLoc Exon Structure for
KCTD15
ECgene alternative splicing isoforms for
KCTD15

Expression for KCTD15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCTD15 Gene

Protein differential expression in normal tissues from HIPED for KCTD15 Gene

This gene is overexpressed in Fetal Brain (17.1), Urinary Bladder (13.7), Fetal heart (12.7), Retina (12.0), and Esophagus (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCTD15 Gene



Protein tissue co-expression partners for KCTD15 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCTD15 Gene:

KCTD15

SOURCE GeneReport for Unigene cluster for KCTD15 Gene:

Hs.221873
genes like me logo Genes that share expression patterns with KCTD15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KCTD15 Gene

Orthologs for KCTD15 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD15 34 35
  • 99.53 (n)
cow
(Bos Taurus)
Mammalia KCTD15 34 35
  • 93.99 (n)
dog
(Canis familiaris)
Mammalia KCTD15 34 35
  • 93.4 (n)
oppossum
(Monodelphis domestica)
Mammalia KCTD15 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCTD15 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kctd15 34
  • 90.22 (n)
mouse
(Mus musculus)
Mammalia Kctd15 34 16 35
  • 88.46 (n)
chicken
(Gallus gallus)
Aves KCTD15 34 35
  • 74.97 (n)
lizard
(Anolis carolinensis)
Reptilia KCTD15 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd15 34
  • 74.38 (n)
MGC76138 34
zebrafish
(Danio rerio)
Actinopterygii kctd15a 35
  • 88 (a)
OneToMany
kctd15b 34
  • 81.32 (n)
KCTD15 (2 of 2) 35
  • 78 (a)
OneToMany
Dr.15592 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007044 34
  • 62.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10440 34 35
  • 60.71 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToMany
Species where no ortholog for KCTD15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCTD15 Gene

ENSEMBL:
Gene Tree for KCTD15 (if available)
TreeFam:
Gene Tree for KCTD15 (if available)

Paralogs for KCTD15 Gene

Paralogs for KCTD15 Gene

(5) SIMAP similar genes for KCTD15 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with KCTD15: view

Variants for KCTD15 Gene

Sequence variations from dbSNP and Humsavar for KCTD15 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10420719 -- 33,814,054(+) CAAGT(A/G)TTCTC utr-variant-3-prime
rs10426916 -- 33,811,375(+) GTGCG(C/G)GTCAC nc-transcript-variant, reference, synonymous-codon, missense
rs1058374 -- 33,813,566(+) CTGGG(A/G)GGAGA utr-variant-3-prime
rs10594025 -- 33,815,706(+) TTTTT(-/TTT)AAAGC cds-indel
rs111378150 -- 33,796,258(+) GCCGC(C/G)TGGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KCTD15 Gene

Variant ID Type Subtype PubMed ID
nsv953278 CNV deletion 24416366
nsv833809 CNV loss 17160897
nsv828528 CNV gain 20364138
nsv579339 CNV gain 21841781
nsv2464 CNV insertion 18451855
esv2758755 CNV gain 17122850
dgv139e55 CNV gain 17911159

Variation tolerance for KCTD15 Gene

Residual Variation Intolerance Score: 41.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCTD15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD15 Gene

Disorders for KCTD15 Gene

Relevant External Links for KCTD15

Genetic Association Database (GAD)
KCTD15
Human Genome Epidemiology (HuGE) Navigator
KCTD15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCTD15

No disorders were found for KCTD15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD15 Gene

Publications for KCTD15 Gene

  1. Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2. (PMID: 23382213) Zarelli V.E. … Dawid I.B. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 4 64
  2. Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study. (PMID: 19910938) Haupt A. … Staiger H. (Obesity (Silver Spring) 2010) 3 46 64
  3. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B. … Franks P.W. (Diabetologia 2010) 3 46 64
  4. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies. (PMID: 20724581) den Hoed M. … Loos R.J. (Diabetes 2010) 3 46 64
  5. Obesity and diabetes genetic variants associated with gestational weight gain. (PMID: 20816152) Stuebe A.M. … Siega-Riz A.M. (Am. J. Obstet. Gynecol. 2010) 3 46 64

Products for KCTD15 Gene

Sources for KCTD15 Gene

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