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Aliases for KCTD15 Gene

Aliases for KCTD15 Gene

  • Potassium Channel Tetramerization Domain Containing 15 2 3 5
  • Potassium Channel Tetramerization Domain-Containing Protein 15 4
  • Potassium Channel Tetramerisation Domain Containing 15 2

External Ids for KCTD15 Gene

Previous GeneCards Identifiers for KCTD15 Gene

  • GC19P038979
  • GC19P034287
  • GC19P030786

Summaries for KCTD15 Gene

GeneCards Summary for KCTD15 Gene

KCTD15 (Potassium Channel Tetramerization Domain Containing 15) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. An important paralog of this gene is KCTD11.

UniProtKB/Swiss-Prot for KCTD15 Gene

  • During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain.

Gene Wiki entry for KCTD15 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD15 Gene

Genomics for KCTD15 Gene

Regulatory Elements for KCTD15 Gene

Enhancers for KCTD15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCTD15 on UCSC Golden Path with GeneCards custom track

Promoters for KCTD15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KCTD15 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCTD15 Gene

Chromosome:
19
Start:
33,795,933 bp from pter
End:
33,815,763 bp from pter
Size:
19,831 bases
Orientation:
Plus strand

Genomic View for KCTD15 Gene

Genes around KCTD15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD15 Gene

Proteins for KCTD15 Gene

  • Protein details for KCTD15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SI1-KCD15_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein KCTD15
    Protein Accession:
    Q96SI1
    Secondary Accessions:
    • A8K600
    • Q9BVI6

    Protein attributes for KCTD15 Gene

    Size:
    283 amino acids
    Molecular mass:
    31942 Da
    Quaternary structure:
    • Interacts with TFAP2A; this interaction inhibits TFAP2A transcriptional activation.

    Alternative splice isoforms for KCTD15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCTD15 Gene

Proteomics data for KCTD15 Gene at MOPED

Post-translational modifications for KCTD15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KCTD15 Gene

Domains & Families for KCTD15 Gene

Protein Domains for KCTD15 Gene

Suggested Antigen Peptide Sequences for KCTD15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96SI1

UniProtKB/Swiss-Prot:

KCD15_HUMAN :
  • Contains 1 BTB (POZ) domain.
Domain:
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD15: view

No data available for Gene Families for KCTD15 Gene

Function for KCTD15 Gene

Molecular function for KCTD15 Gene

UniProtKB/Swiss-Prot Function:
During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain.
genes like me logo Genes that share phenotypes with KCTD15: view

Animal Models for KCTD15 Gene

MGI Knock Outs for KCTD15:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCTD15

miRNA for KCTD15 Gene

miRTarBase miRNAs that target KCTD15

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCTD15 Gene

Localization for KCTD15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCTD15 Gene COMPARTMENTS Subcellular localization image for KCTD15 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD15 Gene

Pathways & Interactions for KCTD15 Gene

genes like me logo Genes that share pathways with KCTD15: view

Gene Ontology (GO) - Biological Process for KCTD15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD15: view

No data available for SIGNOR curated interactions for KCTD15 Gene

Drugs & Compounds for KCTD15 Gene

No Compound Related Data Available

Transcripts for KCTD15 Gene

Unigene Clusters for KCTD15 Gene

Potassium channel tetramerisation domain containing 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD15 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: - -
SP3: - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - - -
SP8: - - -
SP9: -

Relevant External Links for KCTD15 Gene

GeneLoc Exon Structure for
KCTD15
ECgene alternative splicing isoforms for
KCTD15

Expression for KCTD15 Gene

mRNA expression in normal human tissues for KCTD15 Gene

Protein differential expression in normal tissues from HIPED for KCTD15 Gene

This gene is overexpressed in Fetal Brain (17.1), Urinary Bladder (13.7), Fetal heart (12.7), Retina (12.0), and Esophagus (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCTD15 Gene



SOURCE GeneReport for Unigene cluster for KCTD15 Gene Hs.221873

genes like me logo Genes that share expression patterns with KCTD15: view

Protein tissue co-expression partners for KCTD15 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KCTD15 Gene

Orthologs for KCTD15 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCTD15 35
  • 93.99 (n)
  • 99.29 (a)
KCTD15 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCTD15 35
  • 93.4 (n)
  • 98.59 (a)
KCTD15 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kctd15 35
  • 88.46 (n)
  • 97.53 (a)
Kctd15 16
Kctd15 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCTD15 35
  • 99.53 (n)
  • 100 (a)
KCTD15 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kctd15 35
  • 90.22 (n)
  • 97.88 (a)
oppossum
(Monodelphis domestica)
Mammalia KCTD15 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCTD15 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCTD15 35
  • 74.97 (n)
  • 90.94 (a)
KCTD15 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCTD15 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd15 35
  • 74.38 (n)
  • 90.2 (a)
MGC76138 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15592 35
kctd15b 35
  • 81.32 (n)
  • 90.66 (a)
KCTD15 (2 of 2) 36
  • 78 (a)
OneToMany
kctd15a 36
  • 88 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007044 35
  • 62.59 (n)
  • 58.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10440 35
  • 60.71 (n)
  • 54.89 (a)
CG10440 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for KCTD15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCTD15 Gene

ENSEMBL:
Gene Tree for KCTD15 (if available)
TreeFam:
Gene Tree for KCTD15 (if available)

Paralogs for KCTD15 Gene

Paralogs for KCTD15 Gene

(5) SIMAP similar genes for KCTD15 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with KCTD15: view

Variants for KCTD15 Gene

Sequence variations from dbSNP and Humsavar for KCTD15 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs17849437 - 33,801,290(+) TGGGC(A/G)GCCAC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs7259858 -- 33,797,136(+) GGCGC(C/G)GGGGT intron-variant, upstream-variant-2KB
rs8102988 -- 33,812,511(+) CTCCC(A/G)GAATC intron-variant, utr-variant-3-prime
rs8104394 -- 33,807,715(+) actcc(A/G)tctca intron-variant
rs13343785 -- 33,812,214(+) CTCAC(C/G)CTCAC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KCTD15 Gene

Variant ID Type Subtype PubMed ID
dgv1073e1 CNV Complex 17122850
dgv139e55 CNV Gain 17911159
nsv833809 CNV Loss 17160897
nsv911609 CNV Loss 21882294
nsv828528 CNV Gain 20364138
nsv2464 CNV Insertion 18451855

Variation tolerance for KCTD15 Gene

Residual Variation Intolerance Score: 41.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.74% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KCTD15 Gene

Disorders for KCTD15 Gene

Relevant External Links for KCTD15

Genetic Association Database (GAD)
KCTD15
Human Genome Epidemiology (HuGE) Navigator
KCTD15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCTD15

No disorders were found for KCTD15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD15 Gene

Publications for KCTD15 Gene

  1. Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2. (PMID: 23382213) Zarelli V.E. … Dawid I.B. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Genetic variations in SEC16B, MC4R, MAP2K5 and KCTD15 were associated with childhood obesity and interacted with dietary behaviors in Chinese school-age population. (PMID: 25637721) Lv D. … Zhu Y.M. (Gene 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for KCTD15 Gene

Sources for KCTD15 Gene

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