Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KCTD15 Gene

Aliases for KCTD15 Gene

  • Potassium Channel Tetramerization Domain Containing 15 2 3
  • Potassium Channel Tetramerization Domain-Containing Protein 15 4
  • Potassium Channel Tetramerisation Domain Containing 15 2

External Ids for KCTD15 Gene

Previous GeneCards Identifiers for KCTD15 Gene

  • GC19P038979
  • GC19P034287
  • GC19P030786

Summaries for KCTD15 Gene

GeneCards Summary for KCTD15 Gene

KCTD15 (Potassium Channel Tetramerization Domain Containing 15) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. An important paralog of this gene is KCTD11.

UniProtKB/Swiss-Prot for KCTD15 Gene

  • During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain.

Gene Wiki entry for KCTD15 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD15 Gene

Genomics for KCTD15 Gene

Regulatory Elements for KCTD15 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCTD15 Gene

33,795,933 bp from pter
33,815,763 bp from pter
19,831 bases
Plus strand

Genomic View for KCTD15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCTD15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD15 Gene

Proteins for KCTD15 Gene

  • Protein details for KCTD15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD15
    Protein Accession:
    Secondary Accessions:
    • A8K600
    • Q9BVI6

    Protein attributes for KCTD15 Gene

    283 amino acids
    Molecular mass:
    31942 Da
    Quaternary structure:
    • Interacts with TFAP2A; this interaction inhibits TFAP2A transcriptional activation.

    Alternative splice isoforms for KCTD15 Gene


neXtProt entry for KCTD15 Gene

Proteomics data for KCTD15 Gene at MOPED

Post-translational modifications for KCTD15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for KCTD15 Gene

Domains for KCTD15 Gene

Protein Domains for KCTD15 Gene

Suggested Antigen Peptide Sequences for KCTD15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD15: view

No data available for Gene Families for KCTD15 Gene

Function for KCTD15 Gene

Molecular function for KCTD15 Gene

UniProtKB/Swiss-Prot Function:
During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain.

Gene Ontology (GO) - Molecular Function for KCTD15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KCTD15: view

Phenotypes for KCTD15 Gene

GenomeRNAi human phenotypes for KCTD15:
genes like me logo Genes that share phenotypes with KCTD15: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCTD15

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD15 Gene

Localization for KCTD15 Gene

Subcellular locations from

Jensen Localization Image for KCTD15 Gene COMPARTMENTS Subcellular localization image for KCTD15 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD15 Gene

Pathways for KCTD15 Gene

genes like me logo Genes that share pathways with KCTD15: view

Gene Ontology (GO) - Biological Process for KCTD15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD15: view

Transcripts for KCTD15 Gene

Unigene Clusters for KCTD15 Gene

Potassium channel tetramerisation domain containing 15:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCTD15

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD15 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: - -
SP3: - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - - -
SP8: - - -
SP9: -

Relevant External Links for KCTD15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD15 Gene

mRNA expression in normal human tissues for KCTD15 Gene

Protein differential expression in normal tissues for KCTD15 Gene

This gene is overexpressed in Fetal Brain (17.1), Urinary Bladder (13.7), Fetal heart (12.7), Retina (12.0), and Esophagus (9.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCTD15 Gene

SOURCE GeneReport for Unigene cluster for KCTD15 Gene Hs.221873

genes like me logo Genes that share expressions with KCTD15: view

Expression partners for KCTD15 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KCTD15 Gene

Orthologs for KCTD15 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCTD15 35
  • 93.99 (n)
  • 99.29 (a)
KCTD15 36
  • 99 (a)
(Canis familiaris)
Mammalia KCTD15 35
  • 93.4 (n)
  • 98.59 (a)
KCTD15 36
  • 99 (a)
(Mus musculus)
Mammalia Kctd15 35
  • 88.46 (n)
  • 97.53 (a)
Kctd15 16
Kctd15 36
  • 98 (a)
(Pan troglodytes)
Mammalia KCTD15 35
  • 99.53 (n)
  • 100 (a)
KCTD15 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Kctd15 35
  • 90.22 (n)
  • 97.88 (a)
(Monodelphis domestica)
Mammalia KCTD15 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia KCTD15 36
  • 91 (a)
(Gallus gallus)
Aves KCTD15 35
  • 74.97 (n)
  • 90.94 (a)
KCTD15 36
  • 67 (a)
(Anolis carolinensis)
Reptilia KCTD15 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd15 35
  • 74.38 (n)
  • 90.2 (a)
MGC76138 35
(Danio rerio)
Actinopterygii Dr.15592 35
kctd15b 35
  • 81.32 (n)
  • 90.66 (a)
KCTD15 (2 of 2) 36
  • 78 (a)
kctd15a 36
  • 88 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007044 35
  • 62.59 (n)
  • 58.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10440 35
  • 60.71 (n)
  • 54.89 (a)
CG10440 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for KCTD15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCTD15 Gene

Gene Tree for KCTD15 (if available)
Gene Tree for KCTD15 (if available)

Paralogs for KCTD15 Gene

Paralogs for KCTD15 Gene

(5) SIMAP similar genes for KCTD15 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with KCTD15: view

Variants for KCTD15 Gene

Sequence variations from dbSNP and Humsavar for KCTD15 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs14032 -- 33,813,262(-) CTCTT(A/C)CAACC utr-variant-3-prime
rs14810 -- 33,813,998(-) TGGGG(C/G)AGGCA utr-variant-3-prime
rs29944 -- 33,815,993(-) ACCAT(C/T)TTCCC downstream-variant-500B
rs29945 -- 33,810,681(-) TTTTT(G/T)TTTTT intron-variant
rs29946 -- 33,808,960(-) acagc(A/G)tcttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD15 Gene

Variant ID Type Subtype PubMed ID
dgv1073e1 CNV Complex 17122850
dgv139e55 CNV Gain 17911159
nsv833809 CNV Loss 17160897
nsv911609 CNV Loss 21882294
nsv828528 CNV Gain 20364138
nsv2464 CNV Insertion 18451855

Relevant External Links for KCTD15 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD15 Gene

Disorders for KCTD15 Gene

Relevant External Links for KCTD15

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for KCTD15 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KCTD15 Gene

Publications for KCTD15 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa? (PMID: 19746409) Brandys M.K. … Adan R.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 48
  5. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PMID: 19851340) Hotta K. … Nakamura Y. (J. Hum. Genet. 2009) 3 48

Products for KCTD15 Gene

Sources for KCTD15 Gene

Back to Top