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Aliases for KCTD14 Gene

Aliases for KCTD14 Gene

  • Potassium Channel Tetramerization Domain Containing 14 2 3
  • Potassium Channel Tetramerisation Domain Containing 14 2

External Ids for KCTD14 Gene

Previous GeneCards Identifiers for KCTD14 Gene

  • GC11M077453
  • GC11M077404
  • GC11M077726
  • GC11M074025

Summaries for KCTD14 Gene

GeneCards Summary for KCTD14 Gene

KCTD14 (Potassium Channel Tetramerization Domain Containing 14) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. An important paralog of this gene is KCTD11.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD14 Gene

Genomics for KCTD14 Gene

Regulatory Elements for KCTD14 Gene

Genomic Location for KCTD14 Gene

Start:
78,015,715 bp from pter
End:
78,080,219 bp from pter
Size:
64,505 bases
Orientation:
Minus strand

Genomic View for KCTD14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCTD14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD14 Gene

Proteins for KCTD14 Gene

  • Protein details for KCTD14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ13-KCD14_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein KCTD14
    Protein Accession:
    Q9BQ13
    Secondary Accessions:
    • B2R9R8

    Protein attributes for KCTD14 Gene

    Size:
    255 amino acids
    Molecular mass:
    29591 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH01062.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH01929.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BX359005; Type=Frameshift; Positions=182; Evidence={ECO:0000305};

    Alternative splice isoforms for KCTD14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCTD14 Gene

Proteomics data for KCTD14 Gene at MOPED

Post-translational modifications for KCTD14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD14 Gene

No data available for DME Specific Peptides for KCTD14 Gene

Domains for KCTD14 Gene

Protein Domains for KCTD14 Gene

Suggested Antigen Peptide Sequences for KCTD14 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BQ13

UniProtKB/Swiss-Prot:

KCD14_HUMAN :
  • Q9BQ13
Domain:
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD14: view

No data available for Gene Families for KCTD14 Gene

Function for KCTD14 Gene

Gene Ontology (GO) - Molecular Function for KCTD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008137 NADH dehydrogenase (ubiquinone) activity --
genes like me logo Genes that share ontologies with KCTD14: view

Phenotypes for KCTD14 Gene

GenomeRNAi human phenotypes for KCTD14:
genes like me logo Genes that share phenotypes with KCTD14: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KCTD14 Gene

Localization for KCTD14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCTD14 Gene COMPARTMENTS Subcellular localization image for KCTD14 gene
Compartment Confidence
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KCTD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane --
genes like me logo Genes that share ontologies with KCTD14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KCTD14 Gene

Pathways for KCTD14 Gene

genes like me logo Genes that share pathways with KCTD14: view

Interacting Proteins for KCTD14 Gene

Gene Ontology (GO) - Biological Process for KCTD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD14: view

Transcripts for KCTD14 Gene

Unigene Clusters for KCTD14 Gene

Potassium channel tetramerisation domain containing 14:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCTD14

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD14 Gene

No ASD Table

Relevant External Links for KCTD14 Gene

GeneLoc Exon Structure for
KCTD14
ECgene alternative splicing isoforms for
KCTD14

Expression for KCTD14 Gene

mRNA expression in normal human tissues for KCTD14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCTD14 Gene

This gene is overexpressed in Adrenal Gland (8.2) and Pancreas (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCTD14 Gene

SOURCE GeneReport for Unigene cluster for KCTD14 Gene Hs.709780

genes like me logo Genes that share expressions with KCTD14: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KCTD14 Gene

Orthologs for KCTD14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCTD14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD14 35
  • 99.74 (n)
  • 100 (a)
KCTD14 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCTD14 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCTD14 35
  • 74.31 (n)
  • 67.1 (a)
KCTD14 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kctd14 35
  • 69.44 (n)
  • 59.21 (a)
Kctd14 16
Kctd14 36
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCTD14 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kctd14 35
  • 69.68 (n)
  • 61.09 (a)
chicken
(Gallus gallus)
Aves KCTD14 35
  • 60.25 (n)
  • 53.14 (a)
KCTD14 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCTD14 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd14 35
  • 59.42 (n)
  • 51.74 (a)
zebrafish
(Danio rerio)
Actinopterygii KCTD14 36
  • 46 (a)
OneToOne
si:ch73-39g20.5 35
  • 57.96 (n)
  • 50.88 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for KCTD14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCTD14 Gene

ENSEMBL:
Gene Tree for KCTD14 (if available)
TreeFam:
Gene Tree for KCTD14 (if available)

Paralogs for KCTD14 Gene

Paralogs for KCTD14 Gene

Selected SIMAP similar genes for KCTD14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCTD14: view

Variants for KCTD14 Gene

Structural Variations from Database of Genomic Variants (DGV) for KCTD14 Gene

Variant ID Type Subtype PubMed ID
nsv520740 CNV Gain 19592680
nsv516638 CNV Loss 19592680
esv2660024 CNV Deletion 23128226

Relevant External Links for KCTD14 Gene

HapMap Linkage Disequilibrium report
KCTD14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for KCTD14 Gene

Disorders for KCTD14 Gene

No disorders were found for KCTD14 Gene.

No data available for UniProtKB/Swiss-Prot for KCTD14 Gene

Publications for KCTD14 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  4. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for KCTD14 Gene

Sources for KCTD14 Gene

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