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Aliases for KCTD14 Gene

Aliases for KCTD14 Gene

  • Potassium Channel Tetramerization Domain Containing 14 2 3 5
  • Potassium Channel Tetramerisation Domain Containing 14 2

External Ids for KCTD14 Gene

Previous GeneCards Identifiers for KCTD14 Gene

  • GC11M077453
  • GC11M077404
  • GC11M077726
  • GC11M074025

Summaries for KCTD14 Gene

GeneCards Summary for KCTD14 Gene

KCTD14 (Potassium Channel Tetramerization Domain Containing 14) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity. An important paralog of this gene is KCTD10.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD14 Gene

Genomics for KCTD14 Gene

Regulatory Elements for KCTD14 Gene

Enhancers for KCTD14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCTD14 on UCSC Golden Path with GeneCards custom track

Promoters for KCTD14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KCTD14 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCTD14 Gene

78,015,715 bp from pter
78,046,191 bp from pter
30,477 bases
Minus strand

Genomic View for KCTD14 Gene

Genes around KCTD14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD14 Gene

Proteins for KCTD14 Gene

  • Protein details for KCTD14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD14
    Protein Accession:
    Secondary Accessions:
    • B2R9R8

    Protein attributes for KCTD14 Gene

    255 amino acids
    Molecular mass:
    29591 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH01062.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH01929.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BX359005; Type=Frameshift; Positions=182; Evidence={ECO:0000305};

    Alternative splice isoforms for KCTD14 Gene


neXtProt entry for KCTD14 Gene

Proteomics data for KCTD14 Gene at MOPED

Post-translational modifications for KCTD14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCTD14 Gene

Domains & Families for KCTD14 Gene

Protein Domains for KCTD14 Gene

Suggested Antigen Peptide Sequences for KCTD14 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCTD14: view

No data available for Gene Families for KCTD14 Gene

Function for KCTD14 Gene

genes like me logo Genes that share phenotypes with KCTD14: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD14 Gene

Localization for KCTD14 Gene

Subcellular locations from

Jensen Localization Image for KCTD14 Gene COMPARTMENTS Subcellular localization image for KCTD14 gene
Compartment Confidence
nucleus 2
cytosol 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD14 Gene

Pathways & Interactions for KCTD14 Gene

genes like me logo Genes that share pathways with KCTD14: view

Interacting Proteins for KCTD14 Gene

Gene Ontology (GO) - Biological Process for KCTD14 Gene


No data available for SIGNOR curated interactions for KCTD14 Gene

Drugs & Compounds for KCTD14 Gene

No Compound Related Data Available

Transcripts for KCTD14 Gene

mRNA/cDNA for KCTD14 Gene

Unigene Clusters for KCTD14 Gene

Potassium channel tetramerisation domain containing 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD14 Gene

No ASD Table

Relevant External Links for KCTD14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD14 Gene

mRNA expression in normal human tissues for KCTD14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCTD14 Gene

This gene is overexpressed in Adrenal Gland (x8.2) and Pancreas (x7.0).

Protein differential expression in normal tissues from HIPED for KCTD14 Gene

This gene is overexpressed in Salivary gland (27.2) and Skin (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCTD14 Gene

SOURCE GeneReport for Unigene cluster for KCTD14 Gene Hs.709780

genes like me logo Genes that share expression patterns with KCTD14: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KCTD14 Gene

Orthologs for KCTD14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCTD14 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia KCTD14 35
  • 74.31 (n)
  • 67.1 (a)
KCTD14 36
  • 64 (a)
(Mus musculus)
Mammalia Kctd14 35
  • 69.44 (n)
  • 59.21 (a)
Kctd14 16
Kctd14 36
  • 56 (a)
(Pan troglodytes)
Mammalia KCTD14 35
  • 99.74 (n)
  • 100 (a)
KCTD14 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Kctd14 35
  • 69.68 (n)
  • 61.09 (a)
(Bos Taurus)
Mammalia KCTD14 36
  • 68 (a)
(Monodelphis domestica)
Mammalia KCTD14 36
  • 57 (a)
(Gallus gallus)
Aves KCTD14 35
  • 60.25 (n)
  • 53.14 (a)
KCTD14 36
  • 51 (a)
(Anolis carolinensis)
Reptilia KCTD14 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd14 35
  • 59.42 (n)
  • 51.74 (a)
(Danio rerio)
Actinopterygii si:ch73-39g20.5 35
  • 57.96 (n)
  • 50.88 (a)
KCTD14 36
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for KCTD14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCTD14 Gene

Gene Tree for KCTD14 (if available)
Gene Tree for KCTD14 (if available)

Paralogs for KCTD14 Gene

Paralogs for KCTD14 Gene

(1) SIMAP similar genes for KCTD14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCTD14: view

Variants for KCTD14 Gene

Structural Variations from Database of Genomic Variants (DGV) for KCTD14 Gene

Variant ID Type Subtype PubMed ID
nsv520740 CNV Gain 19592680
nsv516638 CNV Loss 19592680
esv2660024 CNV Deletion 23128226

Variation tolerance for KCTD14 Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.95; 59.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for KCTD14 Gene

Disorders for KCTD14 Gene

Relevant External Links for KCTD14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KCTD14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD14 Gene

Publications for KCTD14 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for KCTD14 Gene

Sources for KCTD14 Gene