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KCTD14 Gene

protein-coding   GIFtS: 42
GCID: GC11M077726

Potassium Channel Tetramerization Domain Containing 14

(Previous name: potassium channel tetramerisation domain containing 14)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Channel Tetramerization Domain Containing 141 2
Potassium Channel Tetramerisation Domain Containing 141 2
BTB/POZ Domain-Containing Protein KCTD142

External Ids:    HGNC: 232951   Entrez Gene: 659872   Ensembl: ENSG000001513647   UniProtKB: Q9BQ133   

Export aliases for KCTD14 gene to outside databases

Previous GC identifers: GC11M077453 GC11M077404 GC11M074025


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KCTD14 Gene:
KCTD14 (potassium channel tetramerization domain containing 14) is a protein-coding gene. Diseases associated with KCTD14 include maturity-onset diabetes of the young, and cholera. An important paralog of this gene is KCTD1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the KCTD14 gene promoter:
         Bach1   SRF   NF-1   NF-1/L   AML1a   SRF (504 AA)   STAT5A   HNF-3beta   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCTD14 promoter sequence
   Search Chromatin IP Primers for KCTD14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCTD14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.1   Ensembl cytogenetic band:  11q14.1   HGNC cytogenetic band: 11q13.4

KCTD14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCTD14 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M077726:  view genomic region     (about GC identifiers)

Start:
77,726,761 bp from pter      End:
77,757,237 bp from pter
Size:
30,477 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCD14_HUMAN, Q9BQ13 (See protein sequence)
Recommended Name: BTB/POZ domain-containing protein KCTD14  
Size: 255 amino acids; 29591 Da
Sequence caution: Sequence=AAH01062.1; Type=Erroneous initiation; Sequence=AAH01929.1; Type=Erroneous initiation;
Sequence=BX359005; Type=Frameshift; Positions=182;

Explore the universe of human proteins at neXtProt for KCTD14: NX_Q9BQ13

Explore proteomics data for KCTD14 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KCTD14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001269335.1  NP_076419.2  

    ENSEMBL proteins: 
     ENSP00000316482   ENSP00000431155  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003131 T1-type_BTB

    Graphical View of Domain Structure for InterPro Entry Q9BQ13

    ProtoNet protein and cluster: Q9BQ13

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: KCD14_HUMAN, Q9BQ13
    Similarity: Contains 1 BTB (POZ) domain


    KCTD14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    KCTD14 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for KCTD14:
     Increased G2M DNA content  Increased cell death in HCT116 

    Animal Models:
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    miRNA
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    Block miRNA regulation of human, mouse, rat KCTD14 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate KCTD14:
    hsa-miR-222* hsa-miR-494 hsa-miR-616* hsa-miR-518f* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidKCTD14 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    cytosol1
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCTD14 About    
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37
    Cellular Effects of Sildenafil0.46
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    4Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    MODY (Maturity-Onset Diabetes of Young)0.41

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KCTD14 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCTD14
    Interactions:

        Search GeneGlobe Interaction Network for KCTD14

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for KCTD14 (ENSP000003164824) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDAENSP000003642124STRING: ENSP00000364212
    KIF4AENSP000003635244STRING: ENSP00000363524
    KIF4BENSP000003878754STRING: ENSP00000387875
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051260protein homooligomerization IEA--

    KCTD14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KCTD14 (KCD14)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KCTD14 gene (2 alternative transcripts): 
    NM_001282406.1  NM_023930.3  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000353172(uc001oyw.4 uc021qnr.1 uc021qns.1 uc021qnt.1)
    ENST00000533144
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate KCTD14:
    hsa-miR-222* hsa-miR-494 hsa-miR-616* hsa-miR-518f* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidKCTD14 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for KCTD14
    Predesigned siRNA for gene silencing in human, mouse, rat KCTD14
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    Primer
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    OriGene qPCR primer pairs and template standards for KCTD14
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCTD14
      QuantiTect SYBR Green Assays in human, mouse, rat KCTD14
      QuantiFast Probe-based Assays in human, mouse, rat KCTD14

    Selected AceView cDNA sequences (see all 399):

    BM700256 AA531027 AI073862 CD514699 BU631809 AA855001 AA194882 BX281908 
    AA975096 BQ311752 AA290990 CA431120 AI934779 AA232684 AA075378 AA111971 
    CR624128 CA844343 AA406612 CB961387 BE220615 AA165036 AU106893 AI400365 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCTD14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATCAAGCT
    KCTD14 Expression
    About this image


    KCTD14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Proerythroblasts Hematopoietic Bone Marrow
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Pre-Sertoli Cells Testis Cord
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
    KCTD14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCTD14 Protein Expression
        Custom PCR Arrays for KCTD14
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KCTD14 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kctd141 , 5 potassium channel tetramerisation domain containing more1, 5 69.44(n)1
    59.21(a)1
      7 (53.51 cM)5
    2335291  NM_001136235.11  NP_001129707.11 
     974513345 
    chicken
    (Gallus gallus)
    Aves KCTD141 potassium channel tetramerisation domain containing more 60.25(n)
    53.14(a)
      419029  NM_001277837.1  NP_001264766.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCTD146
    potassium channel tetramerization domain containin...
    52(a)
    1 ↔ 1
    GL343337.1(582119-588313)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kctd141 potassium channel tetramerization domain containing more 59.42(n)
    51.74(a)
      100379838  XM_002936554.2  XP_002936600.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-39g20.51 si:ch73-39g20.5 57.96(n)
    50.88(a)
      564616  XM_687949.4  XP_693041.2 


    ENSEMBL Gene Tree for KCTD14 (if available)
    TreeFam Gene Tree for KCTD14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCTD14 gene
    KCTD12  KCTD82  KCTD152  KCTD162  KCTD42  KCTD112  KCNRG2  KCTD122  
    KCTD212  KCTD62  
    1 SIMAP similar gene for KCTD14 using alignment to 2 protein entries:     KCD14_HUMAN (see all proteins):
    KCTD7

    KCTD14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KCTD14:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660024CNV Deletion23128226
    nsv516638CNV Loss19592680
    nsv520740CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCTD14
    DNA2.0 Custom Variant and Variant Library Synthesis for KCTD14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for KCTD14:    
    About MalaCards
    maturity-onset diabetes of the young    cholera    neuronitis    hepatitis


    KCTD14 for disorders           About GeneDecksing


    Export disorders for KCTD14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCTD14 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KCTD14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    6. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    7. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 65987 HGNC: 23295 AceView: NDUFC2andKCTD14 Ensembl:ENSG00000151364 euGenes: HUgn65987
    ECgene: KCTD14 H-InvDB: KCTD14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCTD14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KCTD14 gene:
    Search GeneIP for patents involving KCTD14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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