Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCTD13 Gene

protein-coding   GIFtS: 51
GCID: GC16M029918

Potassium Channel Tetramerization Domain Containing 13

(Previous name: potassium channel tetramerisation domain containing 13)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Channel Tetramerization Domain Containing 131 2     hBACURD12 3
Polymerase Delta-Interacting Protein 11 2 3     TNFAIP1-Like Protein2 3
POLDIP12 3 5     TNFAIP1-like1
Potassium Channel Tetramerisation Domain Containing 131 2     BTB/POZ Domain-Containing Adapter For CUL3-Mediated RhoA Degradation
Protein 12
PDIP12 3     BACURD13
BTB/POZ Domain-Containing Protein KCTD132 3     FKSG865

External Ids:    HGNC: 222341   Entrez Gene: 2539802   Ensembl: ENSG000001749437   OMIM: 6089475   UniProtKB: Q8WZ193   

Export aliases for KCTD13 gene to outside databases

Previous GC identifers: GC16M029955 GC16M029948 GC16M029826 GC16M029917 GC16M027578


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KCTD13 Gene: 
KCTD13 (potassium channel tetramerization domain containing 13) is a protein-coding gene. Diseases associated with KCTD13 include microcephaly, and maturity-onset diabetes of the young, and among its related super-pathways are Melatonin Signaling and Activation of cAMP-Dependent PKA. GO annotations related to this gene include identical protein binding and protein domain specific binding. An important paralog of this gene is TNFAIP1.

UniProtKB/Swiss-Prot: BACD1_HUMAN, Q8WZ19
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in
regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of
RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration

Gene Wiki entry for KCTD13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCTD13 gene promoter:
         AP-2alpha isoform 3   Sp1   GCNF   AP-2alpha isoform 2   HOXA5   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCTD13 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCTD13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

KCTD13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCTD13 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M029918:  view genomic region     (about GC identifiers)

Start:
29,916,333 bp from pter      End:
29,938,356 bp from pter
Size:
22,024 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BACD1_HUMAN, Q8WZ19 (See protein sequence)
Recommended Name: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1  
Size: 329 amino acids; 36357 Da
Subunit: Component of the BCR(BACURD1) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD13/BACURD1 and
RBX1. Interacts with RHOA; with a preference for RhoA-GDP. Interacts with POLD2 and PCNA
Subcellular location: Nucleus
Secondary accessions: A8K0R5 Q96P93 Q96SA1

Explore the universe of human proteins at neXtProt for KCTD13: NX_Q8WZ19

Explore proteomics data for KCTD13 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WZ19

  • KCTD13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCTD13 Protein Expression
    REFSEQ proteins: NP_849194.1  
    ENSEMBL proteins: 
     ENSP00000311202   ENSP00000455785   ENSP00000459104   ENSP00000454282   ENSP00000460526  
     ENSP00000458486  

    Human Recombinant Protein Products for KCTD13: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KCTD13
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for KCTD13
    GenScript Custom Purified and Recombinant Proteins Services for KCTD13
    Novus Biologicals KCTD13 Protein
    Novus Biologicals KCTD13 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0031463Cul3-RING ubiquitin ligase complex IDA19782033

    KCTD13 for ontologies           About GeneDecksing



    KCTD13 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KCTD13
    GenScript Custom Superior Antibodies Services for KCTD13
    Novus Biologicals KCTD13 Antibodies
    Abcam antibodies for KCTD13
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for KCTD13
    LSBio Antibodies in human, mouse, rat for KCTD13 

    Assay Products for KCTD13: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KCTD13
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KCTD13
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011333 BTB/POZ_fold
     IPR003131 T1-type_BTB
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q8WZ19

    ProtoNet protein and cluster: Q8WZ19

    UniProtKB/Swiss-Prot: BACD1_HUMAN, Q8WZ19
    Similarity: Belongs to the BACURD family
    Similarity: Contains 1 BTB (POZ) domain


    KCTD13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BACD1_HUMAN, Q8WZ19
    Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in
    regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of
    RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration
    Induction: By TNF and IL6/interleukin-6

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity IDA19782033
    GO:0005515protein binding ----
    GO:0017049GTP-Rho binding IDA19782033
    GO:0019904protein domain specific binding IEA--
    GO:0042802identical protein binding IEA--
         
    KCTD13 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KCTD13:
     Increased cell death in HCC-19 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KCTD13 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KCTD13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCTD13 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCTD13 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCTD13
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate KCTD13 (see all 9):
    hsa-miR-206 hsa-miR-588 hsa-miR-4311 hsa-miR-1 hsa-miR-548s hsa-miR-3647-3p hsa-miR-633 hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidKCTD13 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KCTD13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCTD13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KCTD13
    Sirion Biotech Customized adenovirus for overexpression of KCTD13

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KCTD13 (see all 7)
    OriGene ORF clones in mouse, rat for KCTD13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCTD13 (NM_178863)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCTD13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD13
    Sirion Biotech Customized lentivirus for stable overexpression of KCTD13 
                         Customized lentivirus expression plasmids for stable overexpression of KCTD13 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KCTD13
    Search LifeMap BioReagents cell lines for KCTD13
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD13


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KCTD13 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37
    Cellular Effects of Sildenafil0.46
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    4Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    MODY (Maturity-Onset Diabetes of Young)0.41

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCTD13 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling


    UniProtKB/Swiss-Prot: BACD1_HUMAN, Q8WZ19
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCTD13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for KCTD13 (Q8WZ192, 3 ENSP000003112024) via UniProtKB, MINT, STRING, and/or I2D (see all 29)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    KAT7O952512, 3, ENSP000002590214MINT-67836 I2D: score=4 STRING: ENSP00000259021
    LNX1Q8TBB12, 3, ENSP000002639254MINT-67368 I2D: score=4 STRING: ENSP00000263925
    ZMYND19Q96E352, 3, ENSP000002985854MINT-67349 I2D: score=4 STRING: ENSP00000298585
    ARMC7Q9H6L42, 3, ENSP000002455434MINT-66308 I2D: score=4 STRING: ENSP00000245543
    VTA1Q9NP792, 3, ENSP000003566024MINT-66633 I2D: score=4 STRING: ENSP00000356602
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication ISS15726626
    GO:0016477cell migration IMP19782033
    GO:0016567protein ubiquitination IDA19782033
    GO:0035024negative regulation of Rho protein signal transduction IMP19782033
    GO:0043149stress fiber assembly IMP19782033

    KCTD13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KCTD13 (BACD1)

    Search CenterWatch for drugs/clinical trials and news about KCTD13 / BACD1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KCTD13 gene: 
    NM_178863.3  

    Unigene Cluster for KCTD13:

    Potassium channel tetramerisation domain containing 13
    Hs.534590  [show with all ESTs]
    Unigene Representative Sequence: AK097407
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308768 ENST00000568000(uc002duv.3) ENST00000566842(uc021tge.1)
    ENST00000568995 ENST00000563955 ENST00000563264 ENST00000566413 ENST00000561540
    ENST00000568721
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCTD13
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate KCTD13 (see all 9):
    hsa-miR-206 hsa-miR-588 hsa-miR-4311 hsa-miR-1 hsa-miR-548s hsa-miR-3647-3p hsa-miR-633 hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidKCTD13 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KCTD13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCTD13
    Clone
    Products:
         
    OriGene clones in human, mouse for KCTD13 (see all 7)
    OriGene ORF clones in mouse, rat for KCTD13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCTD13 (NM_178863)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCTD13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD13
    Sirion Biotech Customized lentivirus for stable overexpression of KCTD13 
                         Customized lentivirus expression plasmids for stable overexpression of KCTD13 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KCTD13
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat KCTD13
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD13

    Additional mRNA sequence: 

    AF289573.1 AF401315.2 AK097407.1 AK289630.1 AY027918.1 BC036228.1 

    11 DOTS entries:

    DT.310512  DT.97761909  DT.100763899  DT.86852582  DT.91910291  DT.86852581  DT.40311171  DT.436190 
    DT.91757828  DT.95372783  DT.120697946 

    24/125 AceView cDNA sequences (see all 125):

    AW029203 N59321 AI651765 AI650907 AA062930 BQ668650 BC036228 AA960968 
    BU072010 BU074656 AI633916 BX108207 NM_178863 CR625548 CB995205 AF289573 
    BM993150 BI548684 BU076010 N59478 AL558836 AK094903 CD107040 BF793376 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KCTD13    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                          -                 -     -                     
    SP2:                                                                        
    SP3:                          -                 -                           
    SP4:                          -                                             


    ECgene alternative splicing isoforms for KCTD13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCTD13 expression in normal human tissues (normalized intensities)      KCTD13 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAAGTGTG
    KCTD13 Expression
    About this image


    KCTD13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord

    See KCTD13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCTD13

    SOURCE GeneReport for Unigene cluster: Hs.534590

    UniProtKB/Swiss-Prot: BACD1_HUMAN, Q8WZ19
    Tissue specificity: Expressed in a wide variety of tissues

        SABiosciences Custom PCR Arrays for KCTD13
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KCTD13
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat KCTD13
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD13
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KCTD13 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kctd131 , 5 potassium channel tetramerisation domain containing more1, 5 88.65(n)1
    94.22(a)1
      7 (69.25 cM)5
    2338771  NM_172747.21  NP_766335.11 
     1269288795 
    lizard
    (Anolis carolinensis)
    Reptilia KCTD136
    Uncharacterized protein
    78(a)
    1 ↔ 1
    GL343279.1(82104-89766)
    zebrafish
    (Danio rerio)
    Actinopterygii kctd131 potassium channel tetramerisation domain containing more 64.01(n)
    63.8(a)
      100000647  NM_001077151.1  NP_001070619.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG104656
    --
    57(a)
    1 → many
    2R(1227207-1228496)
    worm
    (Caenorhabditis elegans)
    Secernentea ZC239.136
    D2045.86
    (see all 29)
    Protein D2045.8
    (see all 29)
    36(a)
    30(a)
    (see all 29)
    many ↔ many
    many ↔ many
    (see all 29)
    II(3222406-3222827)
    III(10482327-10483927)


    ENSEMBL Gene Tree for KCTD13 (if available)
    TreeFam Gene Tree for KCTD13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCTD13 gene
    TNFAIP12  KCTD102  
    5 SIMAP similar genes for KCTD13 using alignment to 5 protein entries:     BACD1_HUMAN (see all proteins):
    KCTD10    TNFAIP1    KCTD21    SHKBP1    KCTD6

    KCTD13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/389 SNPs in KCTD13 are shown (see all 389)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819064451,2
    --29917957(+) CAGGGA/TGGGGA 1 -- ut310--------
    rs11297001,2
    C,F,A,H--29918034(-) CACCCA/GTCCCA 1 -- ut31 ese323Minor allele frequency- G:0.45MN NS EA NA WA CSA 2514
    rs1848961001,2
    C--29918181(+) AGGGGG/TAGGGT 1 -- ut310--------
    rs2006271021,2
    --29918185(+) GGAGGA/GTCAGA 1 -- ut310--------
    rs1996451861,2
    --29918274(+) ACACGA/GTGCTC 2 H syn10--------
    rs1407438581,2
    C--29918403(+) TCCTCA/GAAGAT 2 F syn10--------
    rs1496620531,2
    C--29918460(+) TCCTTA/CCTTCT 1 -- int10--------
    rs2013749731,2
    --29918477(+) GTCACA/GCAGGG 1 -- int10--------
    rs1456506561,2
    C--29918543(+) TCCTTA/GGGCCT 1 -- int10--------
    rs116495191,2
    C,F,A,H--29918845(+) actcaG/Agcctg 1 -- int11Minor allele frequency- A:0.50NA 4

    HapMap Linkage Disequilibrium report for KCTD13 (29916333 - 29938356 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KCTD13:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv2668n71CNV Loss21882294
    nsv905717CNV Loss21882294


    Human Gene Mutation Database (HGMD): KCTD13
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KCTD13
    DNA2.0 Custom Variant and Variant Library Synthesis for KCTD13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608947    OMIM disorders: --

    5 diseases for KCTD13:    About MalaCards
    microcephaly    maturity-onset diabetes of the young    cholera    hepatitis
    neuronitis


    KCTD13 for disorders           About GeneDecksing


    Export disorders for KCTD13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCTD13 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with KCTD13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen. (PubMed id 11593007)1, 2, 3, 9 He H.... So A.G. (2001)
    2. Cullin mediates degradation of RhoA through evolution arily conserved BTB adaptors to control actin cytoskeleton structure and cell m ovement. (PubMed id 19782033)1, 2 Chen Y....Shao F. (2009)
    3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigen. (PubMed id 15726626)1, 9 Zhou J....Zhang J. (2005)
    7. Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis. (PubMed id 22902628)1 Ghosal G.... Chen J. (2012)
    8. KCTD13 is a major driver of mirrored neuroanatomical p henotypes of the 16p11.2 copy number variant. (PubMed id 22596160)1 Golzio C....Katsanis N. (2012)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 253980 HGNC: 22234 AceView: KCTD13 Ensembl:ENSG00000174943 euGenes: HUgn253980
    ECgene: KCTD13 H-InvDB: KCTD13

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCTD13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCTD13 gene:
    Search GeneIP for patents involving KCTD13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KCTD13  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for KCTD13  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KCTD13  
     OriGene qSTAR qPCR primer pairs in human, mouse for KCTD13   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KCTD13   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KCTD13   OriGene Custom Protein Services for KCTD13  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCTD13
     QIAGEN SeqTarget long-range PCR primers for resequencing KCTD13
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD13
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCTD13
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD13
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD13
     GenScript Custom Purified and Recombinant Proteins Services for KCTD13 GenScript cDNA clones with any tag delivered in your preferred vector for KCTD13
     GenScript Custom Assay Services for KCTD13 GenScript Custom Superior Antibodies Services for KCTD13
     GenScript Custom overexpressing Cell Line Services for KCTD13 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KCTD13 promoter
     Search Chromatin IP Primers for KCTD13
     RT2 qPCR Primer Assay in human, mouse / rat KCTD13
     GNC Network for KCTD13
     SABiosciences PCR Arrays including human, mouse / rat KCTD13
     Search Tocris compounds for KCTD13 (BACD1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KCTD13 antibodies
     KCTD13 proteins
     KCTD13 lysates
     Antibodies for KCTD13
     See all of Abcam's Antibodies, Kits and Proteins for KCTD13
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for KCTD13
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD13
     SwitchGear 3'UTR luciferase reporter plasmids for KCTD13
     SwitchGear Promoter luciferase reporter plasmids for KCTD13
     Search ThermoFisher Antibodies for KCTD13
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD13
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KCTD13
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KCTD13
    Customized:
     lentivirus for stable overexpression of KCTD13
     lentivirus expression plasmids for stable overexpression of KCTD13
     adenovirus for overexpression of KCTD13
     LSBio Antibodies in human, mouse, rat for KCTD13
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KCTD13 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4