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Aliases for KCTD13 Gene

Aliases for KCTD13 Gene

  • Potassium Channel Tetramerization Domain Containing 13 2 3
  • Polymerase Delta-Interacting Protein 1 2 3 4
  • POLDIP1 3 4 6
  • Potassium Channel Tetramerisation Domain Containing 13 2 3
  • BTB/POZ Domain-Containing Protein KCTD13 3 4
  • TNFAIP1-Like Protein 3 4
  • HBACURD1 3 4
  • BACURD1 3 4
  • FKSG86 3 6
  • PDIP1 3 4
  • BTB/POZ Domain-Containing Adapter For CUL3-Mediated RhoA Degradation Protein 1 3
  • TNFAIP1-Like 2

External Ids for KCTD13 Gene

Previous GeneCards Identifiers for KCTD13 Gene

  • GC16M029955
  • GC16M029948
  • GC16M029826
  • GC16M029917
  • GC16M027578
  • GC16M029918
  • GC16M029922

Summaries for KCTD13 Gene

GeneCards Summary for KCTD13 Gene

KCTD13 (Potassium Channel Tetramerization Domain Containing 13) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include identical protein binding and protein domain specific binding. An important paralog of this gene is KCTD10.

UniProtKB/Swiss-Prot for KCTD13 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.

Gene Wiki entry for KCTD13 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD13 Gene

Genomics for KCTD13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCTD13 Gene

29,905,012 bp from pter
29,927,035 bp from pter
22,024 bases
Minus strand

Genomic View for KCTD13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCTD13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD13 Gene

Proteins for KCTD13 Gene

  • Protein details for KCTD13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
    Protein Accession:
    Secondary Accessions:
    • A8K0R5
    • Q96P93
    • Q96SA1

    Protein attributes for KCTD13 Gene

    329 amino acids
    Molecular mass:
    36357 Da
    Quaternary structure:
    • Component of the BCR(BACURD1) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD13/BACURD1 and RBX1. Interacts with RHOA; with a preference for RhoA-GDP. Interacts with POLD2 and PCNA.

neXtProt entry for KCTD13 Gene

Proteomics data for KCTD13 Gene at MOPED

Post-translational modifications for KCTD13 Gene

  • Ubiquitination at Lys34, Lys67, Lys140, and Lys201
  • Modification sites at PhosphoSitePlus

Other Protein References for KCTD13 Gene

No data available for DME Specific Peptides for KCTD13 Gene

Domains for KCTD13 Gene

Protein Domains for KCTD13 Gene

Suggested Antigen Peptide Sequences for KCTD13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8WZ19
  • Contains 1 BTB (POZ) domain.
  • Belongs to the BACURD family.
genes like me logo Genes that share domains with KCTD13: view

No data available for Gene Families for KCTD13 Gene

Function for KCTD13 Gene

Molecular function for KCTD13 Gene

UniProtKB/Swiss-Prot Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.
UniProtKB/Swiss-Prot Induction: By TNF and IL6/interleukin-6.

Gene Ontology (GO) - Molecular Function for KCTD13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA 19782033
GO:0005515 protein binding IPI 16189514
GO:0017049 GTP-Rho binding IDA 19782033
GO:0019904 protein domain specific binding IEA --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with KCTD13: view

Phenotypes for KCTD13 Gene

GenomeRNAi human phenotypes for KCTD13:
genes like me logo Genes that share phenotypes with KCTD13: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCTD13 Gene

Localization for KCTD13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCTD13 Gene

Subcellular locations from

Jensen Localization Image for KCTD13 Gene COMPARTMENTS Subcellular localization image for KCTD13 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KCTD13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0031463 Cul3-RING ubiquitin ligase complex IDA 19782033
genes like me logo Genes that share ontologies with KCTD13: view

Pathways for KCTD13 Gene

genes like me logo Genes that share pathways with KCTD13: view

UniProtKB/Swiss-Prot Q8WZ19-BACD1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for KCTD13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication ISS 15726626
GO:0016477 cell migration IMP 19782033
GO:0016567 protein ubiquitination IEA --
GO:0035024 negative regulation of Rho protein signal transduction IMP 19782033
GO:0043149 stress fiber assembly IMP 19782033
genes like me logo Genes that share ontologies with KCTD13: view

Transcripts for KCTD13 Gene

Unigene Clusters for KCTD13 Gene

Potassium channel tetramerisation domain containing 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCTD13

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KCTD13
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD13 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7
SP1: - - -
SP3: - -
SP4: -

Relevant External Links for KCTD13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD13 Gene

mRNA expression in normal human tissues for KCTD13 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCTD13 Gene

SOURCE GeneReport for Unigene cluster for KCTD13 Gene Hs.534590

mRNA Expression by UniProt/SwissProt for KCTD13 Gene

Tissue specificity: Expressed in a wide variety of tissues.
genes like me logo Genes that share expressions with KCTD13: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KCTD13 Gene

Orthologs for KCTD13 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KCTD13 35
  • 99.59 (n)
  • 100 (a)
KCTD13 36
  • 100 (a)
(Bos Taurus)
Mammalia KCTD13 35
  • 92.81 (n)
  • 95.44 (a)
KCTD13 36
  • 95 (a)
(Canis familiaris)
Mammalia KCTD13 35
  • 93.31 (n)
  • 97.26 (a)
KCTD13 36
  • 97 (a)
(Mus musculus)
Mammalia Kctd13 35
  • 89.54 (n)
  • 95.47 (a)
Kctd13 16
Kctd13 36
  • 94 (a)
(Monodelphis domestica)
Mammalia KCTD13 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Kctd13 35
  • 90.18 (n)
  • 96.12 (a)
(Anolis carolinensis)
Reptilia KCTD13 36
  • 77 (a)
(Danio rerio)
Actinopterygii kctd13 35
  • 66.21 (n)
  • 67.59 (a)
kctd13 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10465 36
  • 56 (a)
(Caenorhabditis elegans)
Secernentea B0281.5 36
  • 31 (a)
B0281.6 36
  • 32 (a)
C17F4.8 36
  • 27 (a)
C40A11.2 36
  • 25 (a)
C40A11.3 36
  • 26 (a)
C40A11.4 36
  • 23 (a)
C40A11.6 36
  • 33 (a)
C40A11.7 36
  • 32 (a)
D2045.8 36
  • 34 (a)
F22E5.11 36
  • 22 (a)
F22E5.12 36
  • 28 (a)
F22E5.13 36
  • 18 (a)
F22E5.6 36
  • 30 (a)
F22E5.8 36
  • 22 (a)
K02F6.5 36
  • 26 (a)
K02F6.8 36
  • 26 (a)
sdz-35 36
  • 30 (a)
T05E12.3 36
  • 25 (a)
T08G3.13 36
  • 29 (a)
ZC239.13 36
  • 37 (a)
ZC239.14 36
  • 29 (a)
ZC239.15 36
  • 28 (a)
ZC239.16 36
  • 32 (a)
ZC239.17 36
  • 33 (a)
ZC239.2 36
  • 22 (a)
ZC239.3 36
  • 28 (a)
ZC239.4 36
  • 27 (a)
ZC239.5 36
  • 26 (a)
ZC239.6 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9320 36
  • 62 (a)
Species with no ortholog for KCTD13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KCTD13 Gene

Gene Tree for KCTD13 (if available)
Gene Tree for KCTD13 (if available)

Paralogs for KCTD13 Gene

Paralogs for KCTD13 Gene

Selected SIMAP similar genes for KCTD13 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KCTD13: view

Variants for KCTD13 Gene

Sequence variations from dbSNP and Humsavar for KCTD13 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs4407079 -- 29,920,578(-) tttac(C/T)agatt intron-variant
rs4420550 -- 29,927,499(-) CCAGG(C/T)CAGCT upstream-variant-2KB
rs4424923 -- 29,927,972(-) aggcc(A/G)aggtg upstream-variant-2KB
rs4609871 -- 29,920,743(-) ATCAA(A/G)ACATG intron-variant
rs5816505 -- 29,925,760(+) TGGGG(-/A)TGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD13 Gene

Variant ID Type Subtype PubMed ID
nsv905717 CNV Loss 21882294
dgv2668n71 CNV Loss 21882294

Relevant External Links for KCTD13 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD13 Gene

Disorders for KCTD13 Gene

No disorders were found for KCTD13 Gene.

No data available for UniProtKB/Swiss-Prot for KCTD13 Gene

Publications for KCTD13 Gene

  1. A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen. (PMID: 11593007) He H. … So A.G. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 23
  2. Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigen. (PMID: 15726626) Zhou J. … Zhang J. (J. Exp. Zoolog. Part A Comp. Exp. Biol. 2005) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4

Products for KCTD13 Gene

Sources for KCTD13 Gene

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