Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KCTD13 Gene

Aliases for KCTD13 Gene

  • Potassium Channel Tetramerization Domain Containing 13 2 3 5
  • Polymerase Delta-Interacting Protein 1 2 3 4
  • Potassium Channel Tetramerisation Domain Containing 13 2 3
  • BTB/POZ Domain-Containing Protein KCTD13 3 4
  • TNFAIP1-Like Protein 3 4
  • HBACURD1 3 4
  • BACURD1 3 4
  • POLDIP1 3 4
  • PDIP1 3 4
  • BTB/POZ Domain-Containing Adapter For CUL3-Mediated RhoA Degradation Protein 1 3
  • CTD-2574D22.4 3
  • TNFAIP1-Like 2
  • FKSG86 3

External Ids for KCTD13 Gene

Previous GeneCards Identifiers for KCTD13 Gene

  • GC16M029955
  • GC16M029948
  • GC16M029826
  • GC16M029917
  • GC16M027578
  • GC16M029918
  • GC16M029922

Summaries for KCTD13 Gene

GeneCards Summary for KCTD13 Gene

KCTD13 (Potassium Channel Tetramerization Domain Containing 13) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Sweet Taste Signaling. GO annotations related to this gene include identical protein binding and protein domain specific binding. An important paralog of this gene is KCTD10.

UniProtKB/Swiss-Prot for KCTD13 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.

Gene Wiki entry for KCTD13 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD13 Gene

Genomics for KCTD13 Gene

Regulatory Elements for KCTD13 Gene

Enhancers for KCTD13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G030444 1.5 FANTOM5 ENCODE 18.2 -519.4 -519387 4.8 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC KCTD13 ENSG00000260304 ZNF689 BCL7C MIR762HG LOC730183 ENSG00000260114 LOC647086 ENSG00000260060 ZNF785
GH16G029898 1.1 ENCODE 18.5 +26.5 26488 3.8 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 ZNF785 ENSG00000260114 CDIPT-AS1 KCTD13 CDIPT TMEM219 C16orf92 FAM57B DOC2A INO80E
GH16G030028 0.8 ENCODE 18.3 -101.6 -101550 0.1 SAP130 SAP30 SIN3A ZSCAN9 PATZ1 ZNF143 MAZ STAT1 TFE3 KLF6 KCTD13 ENSG00000260114 ZNF785 GC16M030027 C16orf92
GH16G030029 0.8 ENCODE 18.3 -101.8 -101800 0.2 ARID4B SIN3A ZSCAN9 RARA ZNF143 MIER1 NCOA1 REST MIER2 TGIF2 YPEL3 KCTD13 ENSG00000260114 ZNF785 GC16M030027 C16orf92
GH16G028930 1.4 Ensembl ENCODE dbSUPER 5.2 +995.3 995257 3.5 PKNOX1 YBX1 BMI1 ZNF48 EGR1 ZNF143 RELB IKZF2 ZBTB11 ZNF426 TUFM SULT1A2 CDC37P1 KCTD13 EIF3C SMG1P2 CD19 GC16P028929
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCTD13 on UCSC Golden Path with GeneCards custom track

Promoters for KCTD13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085129 835 1601 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF207 KLF13

Genomic Location for KCTD13 Gene

Chromosome:
16
Start:
29,905,012 bp from pter
End:
29,927,035 bp from pter
Size:
22,024 bases
Orientation:
Minus strand

Genomic View for KCTD13 Gene

Genes around KCTD13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD13 Gene

Proteins for KCTD13 Gene

  • Protein details for KCTD13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ19-BACD1_HUMAN
    Recommended name:
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
    Protein Accession:
    Q8WZ19
    Secondary Accessions:
    • A8K0R5
    • Q96P93
    • Q96SA1

    Protein attributes for KCTD13 Gene

    Size:
    329 amino acids
    Molecular mass:
    36357 Da
    Quaternary structure:
    • Component of the BCR(BACURD1) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD13/BACURD1 and RBX1. Interacts with RHOA; with a preference for RhoA-GDP. Interacts with POLD2 and PCNA.

    Three dimensional structures from OCA and Proteopedia for KCTD13 Gene

neXtProt entry for KCTD13 Gene

Post-translational modifications for KCTD13 Gene

  • Ubiquitination at isoforms=34, isoforms=140, and isoforms=201
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KCTD13 Gene

Domains & Families for KCTD13 Gene

Protein Domains for KCTD13 Gene

Suggested Antigen Peptide Sequences for KCTD13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WZ19

UniProtKB/Swiss-Prot:

BACD1_HUMAN :
  • Belongs to the BACURD family.
Family:
  • Belongs to the BACURD family.
genes like me logo Genes that share domains with KCTD13: view

No data available for Gene Families for KCTD13 Gene

Function for KCTD13 Gene

Molecular function for KCTD13 Gene

UniProtKB/Swiss-Prot Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.
UniProtKB/Swiss-Prot Induction:
By TNF and IL6/interleukin-6.

Gene Ontology (GO) - Molecular Function for KCTD13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA 19782033
GO:0005515 protein binding IPI 16189514
GO:0017049 GTP-Rho binding IDA 19782033
GO:0019904 protein domain specific binding IEA --
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with KCTD13: view
genes like me logo Genes that share phenotypes with KCTD13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KCTD13 Gene

Localization for KCTD13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCTD13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD13 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCTD13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0016604 nuclear body IDA --
GO:0031463 Cul3-RING ubiquitin ligase complex IDA 19782033
genes like me logo Genes that share ontologies with KCTD13: view

Pathways & Interactions for KCTD13 Gene

genes like me logo Genes that share pathways with KCTD13: view

UniProtKB/Swiss-Prot Q8WZ19-BACD1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for KCTD13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication ISS 15726626
GO:0016477 cell migration IMP 19782033
GO:0016567 protein ubiquitination IEA --
GO:0035024 negative regulation of Rho protein signal transduction IMP 19782033
GO:0043149 stress fiber assembly IMP 19782033
genes like me logo Genes that share ontologies with KCTD13: view

No data available for SIGNOR curated interactions for KCTD13 Gene

Drugs & Compounds for KCTD13 Gene

No Compound Related Data Available

Transcripts for KCTD13 Gene

Unigene Clusters for KCTD13 Gene

Potassium channel tetramerisation domain containing 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD13 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7
SP1: - - -
SP2:
SP3: - -
SP4: -

Relevant External Links for KCTD13 Gene

GeneLoc Exon Structure for
KCTD13
ECgene alternative splicing isoforms for
KCTD13

Expression for KCTD13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCTD13 Gene

Protein differential expression in normal tissues from HIPED for KCTD13 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KCTD13 Gene



Protein tissue co-expression partners for KCTD13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KCTD13 Gene:

KCTD13

SOURCE GeneReport for Unigene cluster for KCTD13 Gene:

Hs.534590

mRNA Expression by UniProt/SwissProt for KCTD13 Gene:

Q8WZ19-BACD1_HUMAN
Tissue specificity: Expressed in a wide variety of tissues.

Evidence on tissue expression from TISSUES for KCTD13 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with KCTD13: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCTD13 Gene

Orthologs for KCTD13 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD13 34 35
  • 99.59 (n)
oppossum
(Monodelphis domestica)
Mammalia KCTD13 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCTD13 34 35
  • 93.31 (n)
cow
(Bos Taurus)
Mammalia KCTD13 34 35
  • 92.81 (n)
rat
(Rattus norvegicus)
Mammalia Kctd13 34
  • 90.18 (n)
mouse
(Mus musculus)
Mammalia Kctd13 34 16 35
  • 89.54 (n)
lizard
(Anolis carolinensis)
Reptilia KCTD13 35
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii kctd13 34 35
  • 66.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10465 35
  • 56 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZC239.13 35
  • 37 (a)
ManyToMany
D2045.8 35
  • 34 (a)
ManyToMany
C40A11.6 35
  • 33 (a)
ManyToMany
ZC239.17 35
  • 33 (a)
ManyToMany
B0281.6 35
  • 32 (a)
ManyToMany
C40A11.7 35
  • 32 (a)
ManyToMany
ZC239.16 35
  • 32 (a)
ManyToMany
B0281.5 35
  • 31 (a)
ManyToMany
F22E5.6 35
  • 30 (a)
ManyToMany
sdz-35 35
  • 30 (a)
ManyToMany
T08G3.13 35
  • 29 (a)
ManyToMany
ZC239.14 35
  • 29 (a)
ManyToMany
F22E5.12 35
  • 28 (a)
ManyToMany
ZC239.15 35
  • 28 (a)
ManyToMany
ZC239.3 35
  • 28 (a)
ManyToMany
C17F4.8 35
  • 27 (a)
ManyToMany
ZC239.4 35
  • 27 (a)
ManyToMany
C40A11.3 35
  • 26 (a)
ManyToMany
K02F6.5 35
  • 26 (a)
ManyToMany
K02F6.8 35
  • 26 (a)
ManyToMany
ZC239.5 35
  • 26 (a)
ManyToMany
C40A11.2 35
  • 25 (a)
ManyToMany
T05E12.3 35
  • 25 (a)
ManyToMany
ZC239.6 35
  • 24 (a)
ManyToMany
C40A11.4 35
  • 23 (a)
ManyToMany
F22E5.11 35
  • 22 (a)
ManyToMany
F22E5.8 35
  • 22 (a)
ManyToMany
ZC239.2 35
  • 22 (a)
ManyToMany
F22E5.13 35
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9320 35
  • 62 (a)
OneToMany
Species where no ortholog for KCTD13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KCTD13 Gene

ENSEMBL:
Gene Tree for KCTD13 (if available)
TreeFam:
Gene Tree for KCTD13 (if available)

Paralogs for KCTD13 Gene

Paralogs for KCTD13 Gene

(5) SIMAP similar genes for KCTD13 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KCTD13: view

Variants for KCTD13 Gene

Sequence variations from dbSNP and Humsavar for KCTD13 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000097510 -- 29,924,311(+) TTAAG(A/T)TTTTA intron-variant, upstream-variant-2KB
rs1000236584 -- 29,910,828(+) GATAG(G/T)GTGGC intron-variant, downstream-variant-500B
rs1000326983 -- 29,923,010(+) GGCTG(A/G)GGTGG intron-variant
rs1000588711 -- 29,910,486(+) ACAGG(C/T)GCATG intron-variant
rs1000934046 -- 29,921,574(+) GTATA(C/T)ACAAG intron-variant, utr-variant-3-prime

Variation tolerance for KCTD13 Gene

Residual Variation Intolerance Score: 20.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD13 Gene

Human Gene Mutation Database (HGMD)
KCTD13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCTD13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KCTD13 Gene

Disorders for KCTD13 Gene

Relevant External Links for KCTD13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCTD13

No disorders were found for KCTD13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD13 Gene

Publications for KCTD13 Gene

  1. A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen. (PMID: 11593007) He H. … So A.G. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 22 64
  2. Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. (PMID: 19782033) Chen Y. … Shao F. (Mol. Cell 2009) 3 4 64
  3. Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigen. (PMID: 15726626) Zhou J. … Zhang J. (J. Exp. Zoolog. Part A Comp. Exp. Biol. 2005) 3 22 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for KCTD13 Gene

Sources for KCTD13 Gene

Content
Loading form....