Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KCTD13 Gene

protein-coding   GIFtS: 51
GCID: GC16M029922

Potassium Channel Tetramerization Domain Containing 13

(Previous name: potassium channel tetramerisation domain containing 13)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Potassium Channel Tetramerization Domain Containing 131 2     BTB/POZ Domain-Containing Protein KCTD132 3
Polymerase Delta-Interacting Protein 11 2 3     hBACURD12 3
POLDIP12 3 5     TNFAIP1-Like Protein2 3
Potassium Channel Tetramerisation Domain Containing 131 2     TNFAIP1-like1
BACURD12 3     BTB/POZ Domain-Containing Adapter For CUL3-Mediated RhoA Degradation
Protein 12
PDIP12 3     FKSG865

External Ids:    HGNC: 222341   Entrez Gene: 2539802   Ensembl: ENSG000001749437   OMIM: 6089475   UniProtKB: Q8WZ193   

Export aliases for KCTD13 gene to outside databases

Previous GC identifers: GC16M029955 GC16M029948 GC16M029826 GC16M029917 GC16M027578 GC16M029918


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for KCTD13 Gene:
KCTD13 (potassium channel tetramerization domain containing 13) is a protein-coding gene. GO annotations related to this gene include identical protein binding and protein domain specific binding. An important paralog of this gene is TNFAIP1.

UniProtKB/Swiss-Prot: BACD1_HUMAN, Q8WZ19
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in
regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of
RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration

Gene Wiki entry for KCTD13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCTD13 gene promoter:
         AP-2alpha isoform 3   Sp1   GCNF   AP-2alpha isoform 2   HOXA5   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCTD13 promoter sequence
   Search Chromatin IP Primers for KCTD13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCTD13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

KCTD13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCTD13 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M029922:  view genomic region     (about GC identifiers)

Start:
29,916,333 bp from pter      End:
29,938,356 bp from pter
Size:
22,024 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: BACD1_HUMAN, Q8WZ19 (See protein sequence)
Recommended Name: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1  
Size: 329 amino acids; 36357 Da
Subunit: Component of the BCR(BACURD1) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD13/BACURD1 and
RBX1. Interacts with RHOA; with a preference for RhoA-GDP. Interacts with POLD2 and PCNA
Secondary accessions: A8K0R5 Q96P93 Q96SA1

Explore the universe of human proteins at neXtProt for KCTD13: NX_Q8WZ19

Explore proteomics data for KCTD13 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys34, Lys67, Lys140, Lys201
  • Modification sites at PhosphoSitePlus

  • See KCTD13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_849194.1  
    ENSEMBL proteins: 
     ENSP00000311202   ENSP00000455785   ENSP00000459104   ENSP00000454282   ENSP00000460526  
     ENSP00000458486  

    KCTD13 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for KCTD13
    OriGene Protein Over-expression Lysate for KCTD13
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KCTD13
    GenScript Custom Purified and Recombinant Proteins Services for KCTD13
    Novus Biologicals KCTD13 Protein
    Novus Biologicals KCTD13 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for KCTD13 

     
    antibodies-online proteins for KCTD13 (3 products) 

     
    antibodies-online peptides for KCTD13

    KCTD13 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KCTD13
    Novus Biologicals KCTD13 Antibodies
    Abcam antibodies for KCTD13
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for KCTD13
    antibodies-online antibodies for KCTD13 (14 products) 

    KCTD13 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KCTD13
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KCTD13
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for KCTD13 
    antibodies-online kits for KCTD13 (18 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003131 T1-type_BTB

    Graphical View of Domain Structure for InterPro Entry Q8WZ19

    ProtoNet protein and cluster: Q8WZ19

    UniProtKB/Swiss-Prot: BACD1_HUMAN, Q8WZ19
    Similarity: Belongs to the BACURD family
    Similarity: Contains 1 BTB (POZ) domain


    Find genes that share domains with KCTD13           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BACD1_HUMAN, Q8WZ19
    Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in
    regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of
    RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration
    Induction: By TNF and IL6/interleukin-6

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity IDA19782033
    GO:0005515protein binding ----
    GO:0017049GTP-Rho binding IDA19782033
    GO:0019904protein domain specific binding IEA--
    GO:0042802identical protein binding IEA--
         
    Find genes that share ontologies with KCTD13           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KCTD13:
     Increased cell death in HCC-19 

         1 MGI phenotypic allele for Kctd13 (no phenotypes)

    Find genes that share phenotypes with KCTD13           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KCTD13

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat KCTD13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCTD13 (see all 9):
    hsa-miR-206 hsa-miR-588 hsa-miR-4311 hsa-miR-1 hsa-miR-548s hsa-miR-3647-3p hsa-miR-633 hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidKCTD13 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KCTD13
    Predesigned siRNA for gene silencing in human, mouse, rat KCTD13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KCTD13

    Clone
    Products:
         
    OriGene clones in human, mouse for KCTD13 (see all 6)
    OriGene ORF clones in mouse, rat for KCTD13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCTD13 (NM_178863)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCTD13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD13

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KCTD13
    Browse ESI BIO Cell Lines and PureStem Progenitors for KCTD13 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    BACD1_HUMAN, Q8WZ19: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0031463Cul3-RING ubiquitin ligase complex IDA19782033

    Find genes that share ontologies with KCTD13           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for KCTD13 About    
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37
    Cellular Effects of Sildenafil0.46
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    4Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    MODY (Maturity-Onset Diabetes of Young)0.41

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KCTD13 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling


    UniProtKB/Swiss-Prot: BACD1_HUMAN, Q8WZ19
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCTD13
    Interactions:

        GeneGlobe Interaction Network for KCTD13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KCTD13 (Q8WZ192, 3 ENSP000003112024) via UniProtKB, MINT, STRING, and/or I2D (see all 29)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    KAT7O952512, 3, ENSP000002590214MINT-67836 I2D: score=4 STRING: ENSP00000259021
    LNX1Q8TBB12, 3, ENSP000002639254MINT-67368 I2D: score=4 STRING: ENSP00000263925
    ZMYND19Q96E352, 3, ENSP000002985854MINT-67349 I2D: score=4 STRING: ENSP00000298585
    ARMC7Q9H6L42, 3, ENSP000002455434MINT-66308 I2D: score=4 STRING: ENSP00000245543
    VTA1Q9NP792, 3, ENSP000003566024MINT-66633 I2D: score=4 STRING: ENSP00000356602
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication ISS15726626
    GO:0016477cell migration IMP19782033
    GO:0016567protein ubiquitination IDA19782033
    GO:0035024negative regulation of Rho protein signal transduction IMP19782033
    GO:0043149stress fiber assembly IMP19782033

    Find genes that share ontologies with KCTD13           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KCTD13 (BACD1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KCTD13 gene: 
    NM_178863.4  

    Unigene Cluster for KCTD13:

    Potassium channel tetramerisation domain containing 13
    Hs.534590  [show with all ESTs]
    Unigene Representative Sequence: AK097407
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308768 ENST00000568000(uc002duv.3) ENST00000566842(uc021tge.1)
    ENST00000568995 ENST00000563955 ENST00000563264 ENST00000566413 ENST00000561540
    ENST00000568721
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KCTD13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCTD13 (see all 9):
    hsa-miR-206 hsa-miR-588 hsa-miR-4311 hsa-miR-1 hsa-miR-548s hsa-miR-3647-3p hsa-miR-633 hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidKCTD13 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KCTD13
    Predesigned siRNA for gene silencing in human, mouse, rat KCTD13
    Clone
    Products:
         
    OriGene clones in human, mouse for KCTD13 (see all 6)
    OriGene ORF clones in mouse, rat for KCTD13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCTD13 (NM_178863)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCTD13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD13
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KCTD13
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat KCTD13
      QuantiTect SYBR Green Assays in human, mouse, rat KCTD13
      QuantiFast Probe-based Assays in human, mouse, rat KCTD13

    Additional mRNA sequence: 

    AF289573.1 AF401315.2 AK097407.1 AK289630.1 AY027918.1 BC036228.1 

    11 DOTS entries:

    DT.310512  DT.97761909  DT.100763899  DT.86852582  DT.91910291  DT.86852581  DT.40311171  DT.436190 
    DT.91757828  DT.95372783  DT.120697946 

    Selected AceView cDNA sequences (see all 125):

    BC036228 AA062930 CR625548 AI651765 AI633916 BQ668650 AF289573 CB995205 
    BU074656 AA960968 BU072010 NM_178863 AW029203 BX108207 AI650907 N59321 
    CK004733 AI816461 N59478 BM974348 AA908948 BE245672 BU076180 CD107040 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KCTD13    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                          -                 -     -                     
    SP2:                                                                        
    SP3:                          -                 -                           
    SP4:                          -                                             


    ECgene alternative splicing isoforms for KCTD13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KCTD13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAAGTGTG
    KCTD13 Expression
    About this image


    KCTD13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Septum   
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord
    KCTD13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCTD13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534590

    UniProtKB/Swiss-Prot: BACD1_HUMAN, Q8WZ19
    Tissue specificity: Expressed in a wide variety of tissues

        Custom PCR Arrays for KCTD13
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KCTD13
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat KCTD13
    QuantiTect SYBR Green Assays in human, mouse, rat KCTD13
    QuantiFast Probe-based Assays in human, mouse, rat KCTD13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for KCTD13 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kctd131 , 5 potassium channel tetramerisation domain containing more1, 5 89.54(n)1
    95.47(a)1
      7 (69.25 cM)5
    2338771  NM_172747.21  NP_766335.11 
     1269288795 
    lizard
    (Anolis carolinensis)
    Reptilia KCTD136
    potassium channel tetramerization domain containin...
    77(a)
    1 ↔ 1
    GL343279.1(82104-89766)
    zebrafish
    (Danio rerio)
    Actinopterygii kctd131 potassium channel tetramerisation domain containing more 66.21(n)
    67.59(a)
      100000647  NM_001077151.1  NP_001070619.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG104656
    --
    56(a)
    1 → many
    2R(1227207-1228496)
    worm
    (Caenorhabditis elegans)
    Secernentea ZC239.136
    D2045.86
    (see all 29)
    Protein D2045.8 (D2045.8) mRNA, complete cds
    (see all 29)
    37(a)
    34(a)
    (see all 29)
    many ↔ many
    many ↔ many
    (see all 29)
    II(3222406-3222827) WBGene00022571
    III(10482327-10483927) WBGene00008425


    ENSEMBL Gene Tree for KCTD13 (if available)
    TreeFam Gene Tree for KCTD13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KCTD13 gene
    TNFAIP12  KCTD102  
    5 SIMAP similar genes for KCTD13 using alignment to 5 protein entries:     BACD1_HUMAN (see all proteins):
    KCTD10    TNFAIP1    KCTD21    SHKBP1    KCTD6

    Find genes that share paralogs with KCTD13           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KCTD13 (see all 389)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819064451,2
    --29917957(+) CAGGGA/TGGGGA 1 -- ut310--------
    rs11297001,2
    C,F,A,H--29918034(-) CACCCA/GTCCCA 1 -- ut31 ese323Minor allele frequency- G:0.45MN NS EA NA WA CSA 2514
    rs1848961001,2
    C--29918181(+) AGGGGG/TAGGGT 1 -- ut310--------
    rs2006271021,2
    --29918185(+) GGAGGA/GTCAGA 1 -- ut310--------
    rs1996451861,2
    --29918274(+) ACACGA/GTGCTC 2 H syn10--------
    rs1407438581,2
    C--29918403(+) TCCTCA/GAAGAT 2 F syn10--------
    rs1496620531,2
    C--29918460(+) TCCTTA/CCTTCT 1 -- int10--------
    rs2013749731,2
    --29918477(+) GTCACA/GCAGGG 1 -- int10--------
    rs1456506561,2
    C--29918543(+) TCCTTA/GGGCCT 1 -- int10--------
    rs116495191,2
    C,F,A,H--29918845(+) actcaG/Agcctg 1 -- int11Minor allele frequency- A:0.50NA 4

    HapMap Linkage Disequilibrium report for KCTD13 (29916333 - 29938356 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KCTD13:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2668n71CNV Loss21882294
    nsv905717CNV Loss21882294

    Human Gene Mutation Database (HGMD): KCTD13
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCTD13
    DNA2.0 Custom Variant and Variant Library Synthesis for KCTD13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608947    OMIM disorders: --


    Find genes that share disorders with KCTD13           About GenesLikeMe


    Export disorders for KCTD13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KCTD13 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with KCTD13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen. (PubMed id 11593007)1, 2, 3, 9 He H.... So A.G. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    2. Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. (PubMed id 19782033)1, 2 Chen Y.... Shao F. (Mol. Cell 2009)
    3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigen. (PubMed id 15726626)1, 9 Zhou J....Zhang J. (J. Exp. Zoolog. Part A Comp. Exp. Biol. 2005)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis. (PubMed id 22902628)1 Ghosal G.... Chen J. (J. Biol. Chem. 2012)
    9. KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant. (PubMed id 22596160)1 Golzio C....Katsanis N. (Nature 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 253980 HGNC: 22234 AceView: KCTD13 Ensembl:ENSG00000174943 euGenes: HUgn253980
    ECgene: KCTD13 H-InvDB: KCTD13

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KCTD13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KCTD13 gene:
    Search GeneIP for patents involving KCTD13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KCTD13  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for KCTD13  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KCTD13  
     OriGene qSTAR qPCR primer pairs in human, mouse for KCTD13   OriGene Purified Protein for KCTD13  
     OriGene ORF clones in mouse, rat for KCTD13   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KCTD13   OriGene Custom Protein Services for KCTD13  

     
     
     Block miRNA regulation of human, mouse, rat KCTD13 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KCTD13
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCTD13 Predesigned siRNA for gene silencing in human, mouse, rat KCTD13
     QuantiFast Probe-based Assays in human, mouse, rat KCTD13 QuantiTect SYBR Green Assays in human, mouse, rat KCTD13
     Custom PCR Arrays for KCTD13 Search Chromatin IP Primers for KCTD13
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat KCTD13  GeneGlobe Interaction Network for KCTD13
     Regulatory tfbs in KCTD13 promoter
     GenScript Custom Purified and Recombinant Proteins Services for KCTD13 GenScript cDNA clones with any tag delivered in your preferred vector for KCTD13
     GenScript Custom Assay Services for KCTD13 GenScript Custom overexpressing Cell Line Services for KCTD13
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for KCTD13 (BACD1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KCTD13 antibodies
     KCTD13 proteins
     KCTD13 lysates
     Antibodies for KCTD13
     See all of Abcam's Antibodies, Kits and Proteins for KCTD13
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for KCTD13
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD13
     SwitchGear 3'UTR luciferase reporter plasmids for KCTD13
     SwitchGear Promoter luciferase reporter plasmids for KCTD13
     Search ThermoFisher Antibodies for KCTD13
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD13
     Browse compounds at ApexBio
     Search Addgene for plasmids for KCTD13
      Search eBioscience for proteins for KCTD13
      Search eBioscience for elisas for KCTD13
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for KCTD13
     antibodies-online antibodies for KCTD13 (14 products)
     antibodies-online kits for KCTD13 (18 products)
     antibodies-online peptides for KCTD13
     antibodies-online proteins for KCTD13 (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KCTD13 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4