Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCTD12 Gene

protein-coding   GIFtS: 58
GCID: GC13M077454

Potassium Channel Tetramerization Domain Containing 12

(Previous names: chromosome 13 open reading frame 2, potassium channel tetramerisation...)
(Previous symbol: C13orf2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Channel Tetramerization Domain Containing 121 2     Chromosome 13 Open Reading Frame 21
C13orf21 2 3     PFETIN2
Predominantly Fetal Expressed T1 Domain1 2 3     BTB/POZ Domain-Containing Protein KCTD122
Potassium Channel Tetramerisation Domain Containing 121 2     KIAA17783
PFET12 3     Pfetin3

External Ids:    HGNC: 146781   Entrez Gene: 1152072   Ensembl: ENSG000001786957   OMIM: 6105215   UniProtKB: Q96CX23   

Export aliases for KCTD12 gene to outside databases

Previous GC identifers: GC13M075255 GC13M075252 GC13M076352 GC13M058151


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KCTD12 Gene: 
KCTD12 (potassium channel tetramerization domain containing 12) is a protein-coding gene. Diseases associated with KCTD12 include bipolar i disorder, and clear cell sarcoma, and among its related super-pathways are Melatonin Signaling and Activation of cAMP-Dependent PKA. An important paralog of this gene is KCTD1.

UniProtKB/Swiss-Prot: KCD12_HUMAN, Q96CX2
Function: Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor
response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating
onset and promoting desensitization (By similarity)

Gene Wiki entry for KCTD12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCTD12 gene promoter:
         AML1a   Pbx1a   Pax-5   POU6F1 (c2)   AP-4   MIF-1   CREB   deltaCREB   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCTD12 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCTD12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q22.3   Ensembl cytogenetic band:  13q22.3   HGNC cytogenetic band: 13q21

KCTD12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCTD12 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M077454:  view genomic region     (about GC identifiers)

Start:
77,454,304 bp from pter      End:
77,460,540 bp from pter
Size:
6,237 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCD12_HUMAN, Q96CX2 (See protein sequence)
Recommended Name: BTB/POZ domain-containing protein KCTD12  
Size: 325 amino acids; 35701 Da
Subunit: Interacts as a tetramer with GABRB1 and GABRB2
Subcellular location: Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell
membrane (By similarity)

Explore the universe of human proteins at neXtProt for KCTD12: NX_Q96CX2

Explore proteomics data for KCTD12 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96CX2

  • KCTD12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCTD12 Protein Expression
    REFSEQ proteins: NP_612453.1  
    ENSEMBL proteins: 
     ENSP00000366694   ENSP00000317141  

    Human Recombinant Protein Products for KCTD12: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for KCTD12
    GenScript Custom Purified and Recombinant Proteins Services for KCTD12
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KCTD12 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0030054cell junction IEA--
    GO:0042734presynaptic membrane IEA--
    GO:0043235receptor complex IEA--
    GO:0045211postsynaptic membrane IEA--

    KCTD12 for ontologies           About GeneDecksing



    KCTD12 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KCTD12
    GenScript Custom Superior Antibodies Services for KCTD12
    Novus Biologicals KCTD12 Antibody
    Abcam antibodies for KCTD12
    Cloud-Clone Corp. Antibodies for KCTD12 
    ThermoFisher Antibodies for KCTD12
    LSBio Antibodies in human, mouse, rat for KCTD12 

    Assay Products for KCTD12: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KCTD12
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KCTD12
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KCTD12 
    Cloud-Clone Corp. CLIAs for KCTD12


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: KCTD12 


    3 InterPro protein domains:
     IPR011333 BTB/POZ_fold
     IPR003131 T1-type_BTB
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q96CX2

    ProtoNet protein and cluster: Q96CX2


    KCTD12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCD12_HUMAN, Q96CX2
    Function: Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor
    response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating
    onset and promoting desensitization (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    KCTD12 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KCTD12:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KCTD12 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KCTD12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCTD12 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCTD12 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCTD12
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate KCTD12 (see all 59):
    hsa-miR-142-5p hsa-miR-323-3p hsa-miR-4307 hsa-miR-607 hsa-miR-300 hsa-miR-200a hsa-miR-139-5p hsa-miR-1260b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KCTD12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCTD12

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KCTD12
    Sirion Biotech Customized adenovirus for overexpression of KCTD12

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KCTD12 (see all 6)
    OriGene ORF clones in mouse, rat for KCTD12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCTD12 (NM_138444)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCTD12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD12
    Sirion Biotech Customized lentivirus for stable overexpression of KCTD12 
                         Customized lentivirus expression plasmids for stable overexpression of KCTD12 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KCTD12
    Search LifeMap BioReagents cell lines for KCTD12
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD12


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KCTD12 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37
    Cellular Effects of Sildenafil0.46
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    4Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    MODY (Maturity-Onset Diabetes of Young)0.41

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCTD12 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCTD12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/21 Interacting proteins for KCTD12 (Q96CX22, 3 ENSP000003171414) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF1BP203332, 3MINT-49423 I2D: score=2 
    RASSF5Q8WWW03, ENSP000003474434I2D: score=3 STRING: ENSP00000347443
    RIPK2O433533, ENSP000002207514I2D: score=2 STRING: ENSP00000220751
    ARAP1Q96P483, ENSP000003772334I2D: score=1 STRING: ENSP00000377233
    ATG5Q9H1Y03, ENSP000003433134I2D: score=1 STRING: ENSP00000343313
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway IEA--
    GO:0051260protein homooligomerization IEA--

    KCTD12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KCTD12 (KCD12)

    Search CenterWatch for drugs/clinical trials and news about KCTD12 / KCD12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KCTD12 gene: 
    NM_138444.3  

    Unigene Cluster for KCTD12:

    Potassium channel tetramerisation domain containing 12
    Hs.644125  [show with all ESTs]
    Unigene Representative Sequence: NM_138444
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377474(uc010aeu.1) ENST00000317765(uc001vka.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCTD12
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate KCTD12 (see all 59):
    hsa-miR-142-5p hsa-miR-323-3p hsa-miR-4307 hsa-miR-607 hsa-miR-300 hsa-miR-200a hsa-miR-139-5p hsa-miR-1260b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KCTD12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCTD12
    Clone
    Products:
         
    OriGene clones in human, mouse for KCTD12 (see all 6)
    OriGene ORF clones in mouse, rat for KCTD12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCTD12 (NM_138444)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCTD12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD12
    Sirion Biotech Customized lentivirus for stable overexpression of KCTD12 
                         Customized lentivirus expression plasmids for stable overexpression of KCTD12 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KCTD12
    OriGene qSTAR qPCR primer pairs in human, mouse for KCTD12
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCTD12
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD12
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD12

    Additional mRNA sequence: 

    AB593182.1 AF052169.1 AF359381.1 AK057635.1 AK128363.1 AK311268.1 AK311543.1 BC013764.1 

    14 DOTS entries:

    DT.99945554  DT.75148475  DT.100649928  DT.95145895  DT.120780028  DT.120780030  DT.120780038  DT.452943 
    DT.120780020  DT.120780027  DT.120780042  DT.120780052  DT.91765696  DT.95145896 

    24/129 AceView cDNA sequences (see all 129):

    AK057635 BU074517 BF589903 BM677106 AA007212 AI082552 N47068 AI188744 
    BG230560 BX093379 BM995949 AW105632 BM723864 BU735630 AA477748 AI350690 
    BM697859 AA570032 BU737138 AA973828 AA007211 BE502121 AW168905 AA115054 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCTD12 expression in normal human tissues (normalized intensities)      KCTD12 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCAAACTTT
    KCTD12 Expression
    About this image


    KCTD12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             PureStem endothelial progenitor RP1-MV2-18
             Human Umbilical Vein Endothelial Cells (HUVEC) (BioTime)   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor ES-236
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Fibroblast (Uncategorized)
             Human Conjunctival Fibroblasts (HConF)   
     
     Umbilical Cord (Extraembryonic Tissues)
             Human Umbilical Vein Endothelial Cells (HUVEC) (BioTime)   

    See KCTD12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCTD12

    SOURCE GeneReport for Unigene cluster: Hs.644125

    UniProtKB/Swiss-Prot: KCD12_HUMAN, Q96CX2
    Tissue specificity: Present in a variety of fetal organs, with highest expression levels in the cochlea and brain
    and, in stark contrast, is detected only at extremely low levels in adult organs, such as brain and lung

        SABiosciences Custom PCR Arrays for KCTD12
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KCTD12
    OriGene qSTAR qPCR primer pairs in human, mouse for KCTD12
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCTD12
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD12
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KCTD12 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kctd121 , 5 potassium channel tetramerisation domain containing more1, 5 94.46(n)1
    99.38(a)1
      14 (51.55 cM)5
    2392171  NM_177715.41  NP_808383.31 
     1029782205 
    lizard
    (Anolis carolinensis)
    Reptilia KCTD126
    Uncharacterized protein
    68(a)
    1 ↔ 1
    3(86712468-86713442)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF270687.12   -- 77.27(n)    CF270687.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY120891.12   -- 76.66(n)   373865  AY120891.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG108301 CG10830 62.39(n)
    50(a)
      42475  NM_142669.4  NP_650926.1 
    worm
    (Caenorhabditis elegans)
    Secernentea VM106R.11 hypothetical protein 50.56(n)
    45.42(a)
      4926896  NM_001083165.1  NP_001076634.1 


    ENSEMBL Gene Tree for KCTD12 (if available)
    TreeFam Gene Tree for KCTD12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCTD12 gene
    KCTD12  KCTD82  KCTD152  KCTD162  KCTD42  KCTD112  KCNRG2  KCTD212  
    KCTD62  KCTD142  
    2 SIMAP similar genes for KCTD12 using alignment to 1 protein entry:     KCD12_HUMAN:
    KCTD16    KCTD8

    KCTD12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/198 SNPs in KCTD12 are shown (see all 198)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1422261891,2
    --77453820(+) CCAGAC/TGACTT 1 -- int10--------
    rs1899323851,2
    --77453996(+) ATCTCA/GAAGCT 1 -- int10--------
    rs1825482571,2
    --77454164(+) TGGCCA/GGTTCC 1 -- int10--------
    rs355271451,2
    C--77454382(+) TCATTA/CCTTCA 1 -- ut312Minor allele frequency- C:0.07NA 122
    rs68351,2
    C,F,H--77454481(-) GAATTT/CCTTCA 1 -- ut3126Minor allele frequency- C:0.21MN NS EA NA WA CSA 2952
    rs1448652901,2
    C--77454515(+) AGACTC/TTGACT 1 -- ut310--------
    rs1480847491,2
    --77454547(+) GGATTA/TTTTTC 1 -- ut310--------
    rs93201,2
    F--77454549(+) ATTTTT/CTTCTT 1 -- ut31 trp32Minor allele frequency- C:0.06MN WA 302
    rs1165399901,2
    C,F--77454789(+) CTTTGT/CCACTA 1 -- ut311Minor allele frequency- C:0.04WA 118
    rs2008298661,2
    C--77454794(+) GTCAC-/AAAATGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KCTD12 (77454304 - 77460540 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KCTD12:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv24441CNV Loss19812545
    nsv832651CNV Gain17160897
    nsv832652CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KCTD12
    DNA2.0 Custom Variant and Variant Library Synthesis for KCTD12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610521    OMIM disorders: --

    9 diseases for KCTD12:    About MalaCards
    bipolar i disorder    clear cell sarcoma    gastrointestinal stromal tumor    maturity-onset diabetes of the young
    coronary heart disease    cholera    sarcoma    hepatitis
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for KCTD12:
    Gastrointestinal stromal tumor

    KCTD12 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KCTD12
    Human Genome Epidemiology (HuGE) Navigator: KCTD12 (3 documents)

    Export disorders for KCTD12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCTD12 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with KCTD12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation from cochlea of a novel human intronless gene with predominant fetal expression. (PubMed id 15357420)1, 2, 3, 9 Resendes B.L.... Morton C.C. (2004)
    2. Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. (PubMed id 19336475)1, 4 Drenos F....Hingorani A.D. (2009)
    3. Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study. (PubMed id 18210030)1, 4 Cauchi S....Froguel P. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Pfetin as a prognostic biomarker of gastrointestinal stromal tumors revealed by proteomics. (PubMed id 18347171)1, 9 Suehara Y....Hirohashi S. (2008)
    6. Use of potassium channel tetramerization domain-contai ning 12 as a biomarker for diagnosis and prognosis of gastrointestinal stromal t umor. (PubMed id 23290008)1 Hasegawa T....Kondo T. (2013)
    7. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. ARAP1 association with CIN85 affects epidermal growth factor receptor endocytic trafficking. (PubMed id 21275903)1 Yoon H.Y....Randazzo P.A. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115207 HGNC: 14678 AceView: KCTD12 Ensembl:ENSG00000178695 euGenes: HUgn115207
    ECgene: KCTD12 H-InvDB: KCTD12

    (According to HUGE)
    About This Section
    HUGE: KIAA1778

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCTD12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCTD12 gene:
    Search GeneIP for patents involving KCTD12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KCTD12  
     OriGene qPCR primer pairs and template standards for KCTD12   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KCTD12  
     OriGene qSTAR qPCR primer pairs in human, mouse for KCTD12   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KCTD12   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KCTD12   OriGene Custom Protein Services for KCTD12  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCTD12
     QIAGEN SeqTarget long-range PCR primers for resequencing KCTD12
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD12
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCTD12
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD12
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD12
     GenScript Custom Purified and Recombinant Proteins Services for KCTD12 GenScript cDNA clones with any tag delivered in your preferred vector for KCTD12
     GenScript Custom Assay Services for KCTD12 GenScript Custom Superior Antibodies Services for KCTD12
     GenScript Custom overexpressing Cell Line Services for KCTD12 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KCTD12 promoter
     Search Chromatin IP Primers for KCTD12
     RT2 qPCR Primer Assay in human, mouse, rat KCTD12
     Search GNC Networks for KCTD12
     SABiosciences PCR Arrays including human, mouse, rat KCTD12
     Search Tocris compounds for KCTD12 (KCD12)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KCTD12 antibodies
     Antibodies for KCTD12
     See all of Abcam's Antibodies, Kits and Proteins for KCTD12
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for KCTD12
     Antibodies for KCTD12
     ELISAs for KCTD12
     CLIAs for KCTD12
     Search LifeMap BioReagents cell lines for KCTD12
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD12
     Browse SwitchGear 3'UTR luciferase reporter plasmids for KCTD12
     SwitchGear Promoter luciferase reporter plasmids for KCTD12
     ThermoFisher Antibodies for KCTD12
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD12
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KCTD12
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KCTD12
    Customized:
     lentivirus for stable overexpression of KCTD12
     lentivirus expression plasmids for stable overexpression of KCTD12
     adenovirus for overexpression of KCTD12
     LSBio Antibodies in human, mouse, rat for KCTD12
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KCTD12 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4