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KCTD12 Gene

protein-coding   GIFtS: 58
GCID: GC13M077454

Potassium Channel Tetramerization Domain Containing 12

(Previous names: chromosome 13 open reading frame 2, potassium channel tetramerisation...)
(Previous symbol: C13orf2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Channel Tetramerization Domain Containing 121 2     KIAA17783 5
C13orf21 2 3 5     Chromosome 13 Open Reading Frame 21
Predominantly Fetal Expressed T1 Domain1 2 3     PFETIN2
PFET12 3 5     BTB/POZ Domain-Containing Protein KCTD122
Potassium Channel Tetramerisation Domain Containing 121 2     Pfetin3

External Ids:    HGNC: 146781   Entrez Gene: 1152072   Ensembl: ENSG000001786957   OMIM: 6105215   UniProtKB: Q96CX23   

Export aliases for KCTD12 gene to outside databases

Previous GC identifers: GC13M075255 GC13M075252 GC13M076352 GC13M058151


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KCTD12 Gene:
KCTD12 (potassium channel tetramerization domain containing 12) is a protein-coding gene. An important paralog of this gene is KCTD1.

UniProtKB/Swiss-Prot: KCD12_HUMAN, Q96CX2
Function: Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor
response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating
onset and promoting desensitization (By similarity)

Gene Wiki entry for KCTD12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCTD12 gene promoter:
         AML1a   Pbx1a   Pax-5   POU6F1 (c2)   AP-4   MIF-1   CREB   deltaCREB   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCTD12 promoter sequence
   Search Chromatin IP Primers for KCTD12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCTD12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q22.3   Ensembl cytogenetic band:  13q22.3   HGNC cytogenetic band: 13q21

KCTD12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCTD12 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M077454:  view genomic region     (about GC identifiers)

Start:
77,454,304 bp from pter      End:
77,460,540 bp from pter
Size:
6,237 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCD12_HUMAN, Q96CX2 (See protein sequence)
Recommended Name: BTB/POZ domain-containing protein KCTD12  
Size: 325 amino acids; 35701 Da
Subunit: Interacts as a tetramer with GABRB1 and GABRB2

Explore the universe of human proteins at neXtProt for KCTD12: NX_Q96CX2

Explore proteomics data for KCTD12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KCTD12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612453.1  
    ENSEMBL proteins: 
     ENSP00000366694   ENSP00000317141  

    KCTD12 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for KCTD12

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: KCTD12


    3 InterPro protein domains:
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003131 T1-type_BTB

    Graphical View of Domain Structure for InterPro Entry Q96CX2

    ProtoNet protein and cluster: Q96CX2


    Find genes that share domains with KCTD12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCD12_HUMAN, Q96CX2
    Function: Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor
    response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating
    onset and promoting desensitization (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with KCTD12           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KCTD12:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCTD12
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KCTD12

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCTD12

    miRNA
    Products:
        
    miRTarBase miRNAs that target KCTD12:
    hsa-let-7b-5p (MIRT032456), hsa-mir-22-3p (MIRT050459), hsa-mir-30d-5p (MIRT047814), hsa-mir-454-3p (MIRT039219), hsa-mir-142-3p (MIRT021600), hsa-mir-335-5p (MIRT019041), hsa-mir-186-5p (MIRT045093), hsa-mir-192-5p (MIRT026816), hsa-mir-215-5p (MIRT024442)

    Block miRNA regulation of human, mouse, rat KCTD12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCTD12 (see all 59):
    hsa-miR-142-5p hsa-miR-323-3p hsa-miR-4307 hsa-miR-607 hsa-miR-300 hsa-miR-200a hsa-miR-139-5p hsa-miR-1260b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat KCTD12

    Gene Editing
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    OriGene clones in human, mouse for KCTD12 (see all 7)
    OriGene ORF clones in mouse, rat for KCTD12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCTD12 (NM_138444)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCD12_HUMAN, Q96CX2: Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell
    membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    plasma membrane3
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030054cell junction IEA--
    GO:0042734presynaptic membrane IEA--
    GO:0043235receptor complex ----
    GO:0045211postsynaptic membrane IEA--

    Find genes that share ontologies with KCTD12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCTD12 About    
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37
    Cellular Effects of Sildenafil0.46
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    4Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    MODY (Maturity-Onset Diabetes of Young)0.41

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KCTD12 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCTD12
    Interactions:

        Search GeneGlobe Interaction Network for KCTD12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for KCTD12 (Q96CX22, 3 ENSP000003171414) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF1BP203332, 3MINT-49423 I2D: score=2 
    RASSF5Q8WWW03, ENSP000003474434I2D: score=3 STRING: ENSP00000347443
    RIPK2O433533, ENSP000002207514I2D: score=2 STRING: ENSP00000220751
    ARAP1Q96P483, ENSP000003772334I2D: score=1 STRING: ENSP00000377233
    ATG5Q9H1Y03, ENSP000003433134I2D: score=1 STRING: ENSP00000343313
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway ----
    GO:0051260protein homooligomerization IEA--

    Find genes that share ontologies with KCTD12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KCTD12 (KCD12)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCTD12 gene: 
    NM_138444.3  

    Unigene Cluster for KCTD12:

    Potassium channel tetramerisation domain containing 12
    Hs.644125  [show with all ESTs]
    Unigene Representative Sequence: NM_138444
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377474(uc010aeu.1) ENST00000317765(uc001vka.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KCTD12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCTD12 (see all 59):
    hsa-miR-142-5p hsa-miR-323-3p hsa-miR-4307 hsa-miR-607 hsa-miR-300 hsa-miR-200a hsa-miR-139-5p hsa-miR-1260b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KCTD12
    Predesigned siRNA for gene silencing in human, mouse, rat KCTD12
    Clone
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    OriGene clones in human, mouse for KCTD12 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCTD12 (NM_138444)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCTD12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD12
    Primer
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    OriGene qPCR primer pairs and template standards for KCTD12
    OriGene qSTAR qPCR primer pairs in human, mouse for KCTD12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCTD12
      QuantiTect SYBR Green Assays in human, mouse, rat KCTD12
      QuantiFast Probe-based Assays in human, mouse, rat KCTD12

    Additional mRNA sequence: 

    AB593182.1 AF052169.1 AF359381.1 AK057635.1 AK128363.1 AK311268.1 AK311543.1 BC013764.1 

    14 DOTS entries:

    DT.99945554  DT.75148475  DT.100649928  DT.95145895  DT.120780028  DT.120780030  DT.120780038  DT.452943 
    DT.120780020  DT.120780027  DT.120780042  DT.120780052  DT.91765696  DT.95145896 

    Selected AceView cDNA sequences (see all 129):

    BU735630 AA570032 AA404400 AI082552 BU737138 AK057635 BC013764 BU625371 
    AI188744 AI350690 BG230560 AW168905 AA115054 BM995949 BX093379 AI246472 
    BE502121 BM677106 AW105632 AA908162 N47068 AA007212 AA973828 AA477748 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCTD12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCAAACTTT
    KCTD12 Expression
    About this image


    KCTD12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
    KCTD12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCTD12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.644125

    UniProtKB/Swiss-Prot: KCD12_HUMAN, Q96CX2
    Tissue specificity: Present in a variety of fetal organs, with highest expression levels in the cochlea and brain
    and, in stark contrast, is detected only at extremely low levels in adult organs, such as brain and lung

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KCTD12 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kctd121 , 5 potassium channel tetramerisation domain containing more1, 5 94.46(n)1
    99.08(a)1
      14 (51.55 cM)5
    2392171  NM_177715.41  NP_808383.31 
     1029765815 
    chicken
    (Gallus gallus)
    Aves KCTD126
    potassium channel tetramerization domain containin...
    68(a)
    1 ↔ 1
    4(11342241-11344315)
    lizard
    (Anolis carolinensis)
    Reptilia KCTD126
    potassium channel tetramerization domain containin...
    68(a)
    1 ↔ 1
    3(86712468-86713442)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF270687.12   -- 77.27(n)    CF270687.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY120891.12   -- 76.66(n)   373865  AY120891.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG108306
    --
    49(a)
    1 → many
    3R(16720174-16723042)
    worm
    (Caenorhabditis elegans)
    Secernentea F32B4.56
    Protein F32B4.5, isoform a (F32B4.5) mRNA, complet...
    19(a)
    1 → many
    I(11517748-11520660) WBGene00009315


    ENSEMBL Gene Tree for KCTD12 (if available)
    TreeFam Gene Tree for KCTD12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCTD12 gene
    KCTD12  KCTD82  KCTD152  KCTD162  KCTD42  KCTD112  KCNRG2  KCTD212  
    KCTD62  KCTD142  
    2 SIMAP similar genes for KCTD12 using alignment to 1 protein entry:     KCD12_HUMAN:
    KCTD16    KCTD8

    Find genes that share paralogs with KCTD12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCTD12 (see all 198)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1422261891,2
    --77453820(+) CCAGAC/TGACTT 1 -- int10--------
    rs1899323851,2
    --77453996(+) ATCTCA/GAAGCT 1 -- int10--------
    rs1825482571,2
    --77454164(+) TGGCCA/GGTTCC 1 -- int10--------
    rs355271451,2
    C--77454382(+) TCATTA/CCTTCA 1 -- ut312Minor allele frequency- C:0.07NA 122
    rs68351,2
    C,F,H--77454481(-) GAATTT/CCTTCA 1 -- ut3126Minor allele frequency- C:0.21MN NS EA NA WA CSA 2952
    rs1448652901,2
    C--77454515(+) AGACTC/TTGACT 1 -- ut310--------
    rs1480847491,2
    --77454547(+) GGATTA/TTTTTC 1 -- ut310--------
    rs93201,2
    F--77454549(+) ATTTTT/CTTCTT 1 -- ut31 trp32Minor allele frequency- C:0.06MN WA 302
    rs1165399901,2
    C,F--77454789(+) CTTTGT/CCACTA 1 -- ut311Minor allele frequency- C:0.04WA 118
    rs2008298661,2
    C--77454794(+) GTCAC-/AAAATGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KCTD12 (77454304 - 77460540 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KCTD12:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv24441CNV Loss19812545
    nsv832651CNV Gain17160897
    nsv832652CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCTD12
    DNA2.0 Custom Variant and Variant Library Synthesis for KCTD12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610521    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for KCTD12:
    Gastrointestinal stromal tumor

    Find genes that share disorders with KCTD12           About GenesLikeMe

    Genetic Association Database (GAD): KCTD12
    Human Genome Epidemiology (HuGE) Navigator: KCTD12 (3 documents)

    Export disorders for KCTD12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCTD12 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with KCTD12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation from cochlea of a novel human intronless gene with predominant fetal expression. (PubMed id 15357420)1, 2, 3, 9 Resendes B.L.... Morton C.C. (J. Assoc. Res. Otolaryngol. 2004)
    2. Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. (PubMed id 19336475)1, 4 Drenos F....Hingorani A.D. (Hum. Mol. Genet. 2009)
    3. Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study. (PubMed id 18210030)1, 4 Cauchi S....Froguel P. (J. Mol. Med. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Pfetin as a prognostic biomarker of gastrointestinal stromal tumors revealed by proteomics. (PubMed id 18347171)1, 9 Suehara Y....Hirohashi S. (Clin. Cancer Res. 2008)
    6. A biophysical characterization of the folded domains of KCTD12: insights into interaction with the GABAB2 receptor. (PubMed id 23996491)1 Correale S....Pedone E. (J. Mol. Recognit. 2013)
    7. Use of potassium channel tetramerization domain-containing 12 as a biomarker for diagnosis and prognosis of gastrointestinal stromal tumor. (PubMed id 23290008)1 Hasegawa T....Kondo T. (Hum. Pathol. 2013)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
    PubMed
    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 115207 HGNC: 14678 AceView: KCTD12 Ensembl:ENSG00000178695 euGenes: HUgn115207
    ECgene: KCTD12 H-InvDB: KCTD12

    (According to HUGE)
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    HUGE: KIAA1778

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCTD12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCTD12 gene:
    Search GeneIP for patents involving KCTD12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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