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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCTD11 Gene

protein-coding   GIFtS: 49
GCID: GC17P007255

potassium channel tetramerisation domain containing 11

(Previous name: chromosome 17 open reading frame 36 )
(Previous symbol: C17orf36)
 Explore 2 diseases affiliated with
KCTD11 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCTD11    

Aliases
for KCTD11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Potassium Channel Tetramerisation Domain Containing 111 2     BTB/POZ Domain-Containing Protein KCTD112
C17orf361 2 3     Potassium Channel Tetramerization Domain Containing 112
REN1 2 3     Retinoic Acid, EGF, NGF Induced Gene Protein2
KCASH11 2     Retinoic Acid, EGF, NGF Induced Gene/Potassium Channel Tetramerization Domain
Containing 112
Chromosome 17 Open Reading Frame 361     REn5
REN/KCTD112     

External Ids:    HGNC: 213021   Entrez Gene: 1470402   Ensembl: ENSG000002138597   OMIM: 6098485   UniProtKB: Q693B13   

Export aliases for KCTD11 gene to outside databases

Previous GC identifers: GC17P007455 GC17P007456 GC17P007196 GC17P007149


Summaries
for KCTD11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: KCD11_HUMAN, Q693B1
Function: Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic
signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth
arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits
cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading
to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and
differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule
cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and
inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates
the caspase cascade




Genomic Views
for KCTD11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCTD11 gene promoter:
         Bach1   Elk-1   RREB-1   NRSF form 1   MyoD   NRSF form 2   E47   Hand1   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCTD11 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCTD11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCTD11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.2

KCTD11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCTD11 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007255:  view genomic region     (about GC identifiers)

Start:
 7,255,208 bp from pter      End:
 7,258,263 bp from pter
Size:
 3,056 bases      Orientation:
 plus strand

Proteins
for KCTD11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCD11_HUMAN, Q693B1 (See protein sequence)
Recommended Name: BTB/POZ domain-containing protein KCTD11  
Size: 232 amino acids; 25887 Da
Subunit: Homotetramer. Component of the BCR(KCTD11) E3 ubiquitin ligase complex, at least composed of CUL3 and KCTD11
and RBX1. Interacts with CUL3
Miscellaneous: Haploinsufficiency of KCTD11 may be a cause of development of medulloblastoma (MDB). MDB is a malignant,
invasive embryonal tumor of the cerebellum with a preferential manifestation in children. An allelic deletion
involving genes from chromosome region 17p11.2-pter, sometimes restricted to 17p13.2-13.3, occurs in up to 50% of MDB
Secondary accessions: B3KPE0
Alternative initiation: 2 isoforms:  Q693B1-1   Q693B1-2   (Non-AUG start codon)

Explore the universe of human proteins at neXtProt for KCTD11: NX_Q693B1

KCTD11 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_001002914.1  
ENSEMBL proteins: 
 ENSP00000328352  

Human Recombinant Protein Products: 
Browse Purified and Recombinant Proteins at EMD Millipore
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OriGene Purified Protein: KCTD11
OriGene Protein Over-expression Lysate: KCTD11
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Novus Biologicals KCTD11 Lysate
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Uscn Proteins for KCTD11

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IEA--


KCTD11 for ontologies           About GeneDecksing



KCTD11 Antibody Products: 
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Uscn Antibodies for KCTD11
Search ThermoFisher Antibodies for KCTD11

Assay Products for KCTD11: 
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GenScript Custom Assay Services for KCTD11
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Uscn ELISAs and CLIAs for KCTD11

Protein Domains /
Families
for KCTD11 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
KCTD11 for domains           About GeneDecksing

2 InterPro domains/families:
 IPR011333 BTB/POZ_fold
 IPR003131 T1-type_BTB

Graphical View of Domain Structure for InterPro Entry Q693B1

ProtoNet protein and cluster: Q693B1

UniProtKB/Swiss-Prot: KCD11_HUMAN, Q693B1
Domain: The BTB domain is required for growth-suppressing properties
Similarity: Contains 1 BTB (POZ) domain


Function
for KCTD11 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: KCD11_HUMAN, Q693B1
Function: Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic
signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth
arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits
cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading
to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and
differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule
cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and
inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates
the caspase cascade

miRNA
Products:    		 OriGene 3'-UTR Clone: KCTD11
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCTD11
8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate KCTD11 (see all 19):
hsa-miR-3934 hsa-miR-4286 hsa-miR-362-3p hsa-miR-125a-3p hsa-miR-520a-5p hsa-miR-764 hsa-miR-3116 hsa-miR-1914
SwitchGear 3'UTR luciferase reporter plasmid: KCTD11 3' UTR sequence
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCTD11 (see all 7)
OriGene shRNA RFP: KCTD11
OriGene siRNA: KCTD11
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCTD11

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for KCTD11

Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD11
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD11 

Cell Line
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Search LifeMap BioReagents cell lines for KCTD11

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD11


Pathways & Interactions
for KCTD11 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Sweet Taste Signaling
Sweet Taste Signaling1.00
Bitter Taste Signaling0.44
Melatonin Signaling0.72
Sperm Motility0.36
Cellular Effects of Sildenafil0.46
2Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA1.00
PKA Signaling0.56
cAMP Pathway0.77
3Neuropathic Pain-Signaling in Dorsal Horn Neurons
Neuropathic Pain-Signaling in Dorsal Horn Neurons1.00
Cholera Infection0.40
Aldosterone Signaling in Epithelial Cells0.47
4Hepatic ABC Transporters
Hepatic ABC Transporters1.00
MODY (Maturity-Onset Diabetes of Young)0.41

5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCTD11 (see all 13)
    Cholera Infection
Neuropathic Pain-Signaling in Dorsal Horn Neurons
Hepatic ABC Transporters
PKA Signaling
Sweet Taste Signaling


UniProtKB/Swiss-Prot: KCD11_HUMAN, Q693B1
Pathway: Protein modification; protein ubiquitination

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCTD11

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for KCTD11 (Q693B13 ENSP000003283524) via UniProtKB, MINT, STRING, and/or I2D

InteractantInteraction Details
GeneCardExternal ID(s)
CUL3Q136183, ENSP000002644144I2D: score=1 STRING: ENSP00000264414
HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
RENENSP000002721904STRING: ENSP00000272190
About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007049cell cycle IEA--
GO:0007399nervous system development ----
GO:0007406negative regulation of neuroblast proliferation IEA--
GO:0016567protein ubiquitination IEA--
GO:0030154cell differentiation ----


KCTD11 for ontologies           About GeneDecksing



Drugs & Compounds
for KCTD11 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KCTD11
Search CenterWatch for drugs/clinical trials and news about KCTD11 / KCD11 

Transcripts
for KCTD11 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for KCTD11 gene: 
NM_001002914.2  

Unigene Cluster for KCTD11:

Potassium channel tetramerisation domain containing 11
Hs.592112  [show with all ESTs]
Unigene Representative Sequence: NM_001002914
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000576980 ENST00000333751(uc002gge.4)

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCTD11
8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate KCTD11 (see all 19):
hsa-miR-3934 hsa-miR-4286 hsa-miR-362-3p hsa-miR-125a-3p hsa-miR-520a-5p hsa-miR-764 hsa-miR-3116 hsa-miR-1914
SwitchGear 3'UTR luciferase reporter plasmid: KCTD11 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCTD11 (see all 7)
OriGene shRNA RFP: KCTD11
OriGene siRNA: KCTD11
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCTD11
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCTD11
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GenScript: all cDNA clones in your preferred vector: KCTD11 (NM_001002914)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCTD11
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD11 
Primer
Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCTD11
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCTD11
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCTD11
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCTD11

Additional cDNA sequence: 

AK056227.1 AY646650.1 BC019929.1 BC063604.1 BC103744.1 BC110598.2 

2 DOTS entries:

DT.435526  DT.95360331 

24/190 AceView cDNA sequences (see all 190):

BI518826 BQ063688 BM783524 D30758 AI962752 BT009788 BM469684 BI029099 
BG678759 BX480095 BC063604 BQ011639 BC018543 NM_014716 AY646650 CF995075 
AI625175 BG490596 AK056227 BI966732 AA380395 CD558797 BI962890 NM_001002914 

GeneLoc Exon Structure


Expression
for KCTD11 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCTD11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTACAAGA

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

KCTD11 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
LiverLiver LobuleLiver
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See KCTD11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCTD11

SOURCE GeneReport for Unigene cluster: Hs.592112

UniProtKB/Swiss-Prot: KCD11_HUMAN, Q693B1
Tissue specificity: Higher expression in cerebellum than in whole brain and lower expression in medulloblastoma

    SABiosciences Expression via Pathway-Focused PCR Array including KCTD11: 
          Hedgehog Signaling Pathway in human mouse rat

Primer
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In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD11

Orthologs
for KCTD11 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
   --

ENSEMBL Gene Tree for KCTD11 (if available)
TreeFam Gene Tree for KCTD11 (if available) 

Paralogs
for KCTD11 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for KCTD11 gene
KCTD12  KCTD152  KCTD82  KCTD162  KCTD42  KCNRG2  KCTD122  KCTD212  
KCTD62  KCTD142  
1 SIMAP similar gene for KCTD11 using alignment to 1 protein entry:     KCD11_HUMAN:
KCTD21

KCTD11 for paralogs           About GeneDecksing



Genomic Variants
for KCTD11 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/50 NCBI SNPs in KCTD11 are shown (see all 50)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 17 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs756879311,2
F,--7255881(+) AAATCG/AGATAC 1 -- ut511Minor allele frequency- A:0.03NA 120
rs1393445911,2
--7255911(+) TTCCCC/TTCTCT 1 -- ut510--------
rs1897177091,2
--7256072(+) ACAGCG/TTCGAC 1 -- ut510--------
rs80801821,2
C,F,A,H,--7256325(+) GAGGCG/AGCCAC 2 /S /G mis115Minor allele frequency- A:0.02NS EA NA WA EU 7009
rs1402772481,2
F--7256372(+) ATCCTC/AAATTT 2 /L syn11Minor allele frequency- A:0.00NA 4424
rs617376581,2
C,F,--7256477(+) GACGCG/CCTGCG 2 /A syn12Minor allele frequency- C:0.00NS NA 4456
rs1411104641,2
C,F--7256503(+) TCAGGG/AGACCC 3 /E /G us2k1 mis11Minor allele frequency- A:0.00NA 4452
rs2007435341,2
--7256507(+) GGGACC/TCCTGC 3 T us2k1 syn10--------
rs2000848601,2
--7256514(+) CTGCAC/TCCACA 3 P S mis1 us2k10--------
rs784939761,2
C,F,--7256541(-) ATCTAC/TATCTG 3 I V us2k1 mis12Minor allele frequency- T:0.00WA NA 4532

HapMap Linkage Disequilibrium report for KCTD11 (7255208 - 7258263 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for KCTD11: --
Human Gene Mutation Database (HGMD): KCTD11

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCTD11
DNA2.0 Custom Variant and Variant Library Synthesis for KCTD11

Disorders / Diseases
for KCTD11 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
KCTD11 for disorders           About GeneDecksing

OMIM gene information: 609848    OMIM disorders: --

2 diseases for KCTD11:    About MalaCards
medulloblastoma    neuronitis

1 disease from the University of Copenhagen DISEASES database for KCTD11:
Medulloblastoma
Human Genome Epidemiology (HuGE) Navigator: KCTD11 (1 document)

Export disorders for KCTD11 gene to outside databases

Publications
for KCTD11 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for KCTD11 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with KCTD11)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characterization of KCASH2 and KCA SH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog acti vity in medulloblastoma. (PubMed id 21472142)1, 3 De Smaele E....Gulino A. (2011)
  2. Molecular organization of the cullin E3 ligase adapto r KCTD11. (PubMed id 21237243)1, 2 Correale S....Pedone E.M. (2011)
  3. Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation. (PubMed id 20081843)1, 2 Canettieri G....Gulino A. (2010)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  6. REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma. (PubMed id 15249678)1, 2 Di Marcotullio L.... Gulino A. (2004)
  7. REN: a novel, developmentally regulated gene that promotes neural cell differentiation. (PubMed id 12186855)1, 3 Gallo R....Gulino A. (2002)
  8. The tumor suppressor gene KCTD11REN is regulated by S p1 and methylation and its expression is reduced in tumors. (PubMed id 20591193)1 Mancarelli M.M....Alesse E. (2010)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  10. KCTD11 expression in medulloblastoma is lower than in adult cerebellum and higher than in neural stem cells. (PubMed id 16965951)9 Zawlik I....Rieske P. (2006)

External Searches for KCTD11 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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Genome Databases showing KCTD11 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 147040 HGNC: 21302 AceView: CENTB1andKCTD11 Ensembl:ENSG00000213859 euGenes: HUgn147040
ECgene: KCTD11 H-InvDB: KCTD11

Other Databases showing KCTD11 gene

(According to HUGE)
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Specialized Databases showing KCTD11 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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PharmGKB entry for KCTD11 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for KCTD11 Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property
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IP news from LifeMap Sciences, Inc.)
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