Aliases for KCTD11 Gene
External Ids for KCTD11 Gene
Previous Symbols for KCTD11 Gene
GeneCards Summary for KCTD11 Gene
KCTD11 (Potassium Channel Tetramerization Domain Containing 11) is a Protein Coding gene. Among its related pathways are p70S6K Signaling and Activation of cAMP-Dependent PKA. An important paralog of this gene is KCTD21.
UniProtKB/Swiss-Prot for KCTD11 Gene
Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.