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Aliases for KCTD10 Gene

Aliases for KCTD10 Gene

  • Potassium Channel Tetramerization Domain Containing 10 2 3 5
  • Potassium Channel Tetramerization Domain-Containing Protein 10 3 4
  • Potassium Channel Tetramerisation Domain Containing 10 2 3
  • BTB/POZ Domain-Containing Protein KCTD10 3 4
  • HBACURD3 3 4
  • BTB/POZ Domain-Containing Adapter For CUL3-Mediated RhoA Degradation Protein 3 3
  • MSTP028 3
  • BTBD28 3
  • ULRO61 3
  • ULR061 4

External Ids for KCTD10 Gene

Previous GeneCards Identifiers for KCTD10 Gene

  • GC12M108349
  • GC12M109887
  • GC12M106904

Summaries for KCTD10 Gene

Entrez Gene Summary for KCTD10 Gene

  • The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for KCTD10 Gene

KCTD10 (Potassium Channel Tetramerization Domain Containing 10) is a Protein Coding gene. Among its related pathways are Hepatic ABC Transporters and Sweet Taste Signaling. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is KCTD13.

UniProtKB/Swiss-Prot for KCTD10 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

Additional gene information for KCTD10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD10 Gene

Genomics for KCTD10 Gene

Regulatory Elements for KCTD10 Gene

Enhancers for KCTD10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H109475 1.4 ENCODE dbSUPER 45.4 +0.5 503 2.9 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF302 KCTD10 IFT81 ALKBH2 UBE3B SART3 FAM216A USP30 LINC01486 ARPC3 CORO1C
GH12H109457 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.1 +14.5 14528 11.2 PKNOX1 ARNT ARID4B SIN3A FEZF1 TCF12 ZNF766 ELK1 FOS ATF7 KCTD10 MYO1H TRPV4 UBE3B MVK ENSG00000255655
GH12H109878 1.6 FANTOM5 ENCODE dbSUPER 21.6 -403.0 -402985 3.4 HDGF ATF1 ARNT ZNF133 SIN3A ZNF2 ZBTB7B ELK1 ZNF143 FOS KCTD10 UBE3B GLTP LINC01486 ENSG00000257268 RNU4-32P IFT81 ANKRD13A PPP1CC FAM216A
GH12H109517 1.2 Ensembl ENCODE dbSUPER 21.6 -41.5 -41484 2.9 CTCF ZNF654 RB1 JUN BHLHE40 TRIM22 REST RAD21 POLR2A ZNF143 KCTD10 MVK FAM222A-AS1 RNU4-32P MMAB ENSG00000255655 PIR34953 PIR31921 GC12P109501
GH12H109051 1.2 ENCODE 20.9 +424.1 424051 3.1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC ZC3H11A SART3 UBE3B KCTD10 ALKBH2 WSCD2 USP30 CORO1C RNU4-32P TCHP USP30-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCTD10 on UCSC Golden Path with GeneCards custom track

Promoters for KCTD10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000057178 -56 2001 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF302

Genomic Locations for KCTD10 Gene

Genomic Locations for KCTD10 Gene
chr12:109,448,655-109,477,544
(GRCh38/hg38)
Size:
28,890 bases
Orientation:
Minus strand
chr12:109,886,460-109,915,349
(GRCh37/hg19)

Genomic View for KCTD10 Gene

Genes around KCTD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD10 Gene

Proteins for KCTD10 Gene

  • Protein details for KCTD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3F6-BACD3_HUMAN
    Recommended name:
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
    Protein Accession:
    Q9H3F6
    Secondary Accessions:
    • Q53HN2
    • Q59FV1
    • Q6PL47
    • Q96SU0

    Protein attributes for KCTD10 Gene

    Size:
    313 amino acids
    Molecular mass:
    35432 Da
    Quaternary structure:
    • Component of the BCR(BACURD3) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and RBX1. Interacts with DNA polymerase delta subunit 2/POLD2 (By similarity). Interacts with PCNA.
    SequenceCaution:
    • Sequence=BAB55188.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD92595.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KCTD10 Gene

    Alternative splice isoforms for KCTD10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCTD10 Gene

Post-translational modifications for KCTD10 Gene

  • Ubiquitination at isoforms=225, posLast=3232, and posLast=171171
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KCTD10 Gene

Domains & Families for KCTD10 Gene

Gene Families for KCTD10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KCTD10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H3F6

UniProtKB/Swiss-Prot:

BACD3_HUMAN :
  • Belongs to the BACURD family.
Family:
  • Belongs to the BACURD family.
genes like me logo Genes that share domains with KCTD10: view

Function for KCTD10 Gene

Molecular function for KCTD10 Gene

UniProtKB/Swiss-Prot Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

Phenotypes From GWAS Catalog for KCTD10 Gene

Gene Ontology (GO) - Molecular Function for KCTD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity ISS --
GO:0005112 Notch binding IPI 25401743
GO:0005515 protein binding IPI 19615732
genes like me logo Genes that share ontologies with KCTD10: view
genes like me logo Genes that share phenotypes with KCTD10: view

Animal Models for KCTD10 Gene

MGI Knock Outs for KCTD10:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCTD10 Gene

Localization for KCTD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCTD10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD10 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KCTD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0031463 Cul3-RING ubiquitin ligase complex ISS --
genes like me logo Genes that share ontologies with KCTD10: view

Pathways & Interactions for KCTD10 Gene

genes like me logo Genes that share pathways with KCTD10: view

UniProtKB/Swiss-Prot Q9H3F6-BACD3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for KCTD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IDA 25401743
GO:0016567 protein ubiquitination ISS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD10: view

No data available for SIGNOR curated interactions for KCTD10 Gene

Drugs & Compounds for KCTD10 Gene

No Compound Related Data Available

Transcripts for KCTD10 Gene

Unigene Clusters for KCTD10 Gene

Potassium channel tetramerisation domain containing 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - -
SP7: - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - - -
SP12: - - - - -
SP13: - - - -
SP14: - -

Relevant External Links for KCTD10 Gene

GeneLoc Exon Structure for
KCTD10
ECgene alternative splicing isoforms for
KCTD10

Expression for KCTD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCTD10 Gene

Protein differential expression in normal tissues from HIPED for KCTD10 Gene

This gene is overexpressed in Bone marrow stromal cell (49.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KCTD10 Gene



NURSA nuclear receptor signaling pathways regulating expression of KCTD10 Gene:

KCTD10

SOURCE GeneReport for Unigene cluster for KCTD10 Gene:

Hs.524731

Evidence on tissue expression from TISSUES for KCTD10 Gene

  • Nervous system(4.9)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with KCTD10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCTD10 Gene

Orthologs for KCTD10 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD10 33
  • 99.04 (n)
cow
(Bos Taurus)
Mammalia KCTD10 33 34
  • 93.08 (n)
dog
(Canis familiaris)
Mammalia KCTD10 33 34
  • 92.37 (n)
oppossum
(Monodelphis domestica)
Mammalia KCTD10 34
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kctd10 33
  • 89.99 (n)
mouse
(Mus musculus)
Mammalia Kctd10 33 16 34
  • 89.67 (n)
chicken
(Gallus gallus)
Aves KCTD10 33 34
  • 83.81 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd10 33
  • 77.74 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7517 33
zebrafish
(Danio rerio)
Actinopterygii kctd10 33 34
  • 79.98 (n)
wufb30g12 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7817 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006173 33
  • 69.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10465 33 34
  • 63.35 (n)
worm
(Caenorhabditis elegans)
Secernentea D2045.8 33 34
  • 47.96 (n)
ZC239.13 34
  • 39 (a)
ManyToMany
ZC239.16 34
  • 35 (a)
ManyToMany
ZC239.17 34
  • 34 (a)
ManyToMany
C40A11.6 34
  • 33 (a)
ManyToMany
B0281.6 34
  • 32 (a)
ManyToMany
C40A11.7 34
  • 31 (a)
ManyToMany
F22E5.6 34
  • 31 (a)
ManyToMany
sdz-35 34
  • 31 (a)
ManyToMany
ZC239.14 34
  • 30 (a)
ManyToMany
B0281.5 34
  • 29 (a)
ManyToMany
C17F4.8 34
  • 29 (a)
ManyToMany
C40A11.3 34
  • 29 (a)
ManyToMany
ZC239.15 34
  • 29 (a)
ManyToMany
C40A11.2 34
  • 27 (a)
ManyToMany
T08G3.13 34
  • 27 (a)
ManyToMany
ZC239.3 34
  • 27 (a)
ManyToMany
ZC239.4 34
  • 27 (a)
ManyToMany
F22E5.12 34
  • 26 (a)
ManyToMany
K02F6.5 34
  • 26 (a)
ManyToMany
K02F6.8 34
  • 25 (a)
ManyToMany
T05E12.3 34
  • 25 (a)
ManyToMany
ZC239.5 34
  • 25 (a)
ManyToMany
C40A11.4 34
  • 24 (a)
ManyToMany
F22E5.8 34
  • 24 (a)
ManyToMany
ZC239.2 34
  • 24 (a)
ManyToMany
ZC239.6 34
  • 24 (a)
ManyToMany
F22E5.11 34
  • 21 (a)
ManyToMany
F22E5.13 34
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9320 34
  • 68 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.106 33
Species where no ortholog for KCTD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD10 Gene

ENSEMBL:
Gene Tree for KCTD10 (if available)
TreeFam:
Gene Tree for KCTD10 (if available)

Paralogs for KCTD10 Gene

Paralogs for KCTD10 Gene

Pseudogenes.org Pseudogenes for KCTD10 Gene

genes like me logo Genes that share paralogs with KCTD10: view

Variants for KCTD10 Gene

Sequence variations from dbSNP and Humsavar for KCTD10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000597960 -- 109,479,487(+) ATGTC(A/G)GATAG intron-variant, upstream-variant-2KB
rs1000656628 -- 109,450,270(+) TCCTT(C/T)GCAGG nc-transcript-variant, utr-variant-3-prime
rs1000721947 -- 109,462,620(+) GGGCT(A/G)AGGCT intron-variant
rs1000794545 -- 109,462,279(+) CAGCC(A/T)AAAGT intron-variant
rs1000805943 -- 109,473,666(+) GCATT(C/G/T)GTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD10 Gene

Variant ID Type Subtype PubMed ID
esv3580463 CNV loss 25503493

Variation tolerance for KCTD10 Gene

Residual Variation Intolerance Score: 30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCTD10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCTD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD10 Gene

Disorders for KCTD10 Gene

Relevant External Links for KCTD10

Genetic Association Database (GAD)
KCTD10
Human Genome Epidemiology (HuGE) Navigator
KCTD10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCTD10

No disorders were found for KCTD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD10 Gene

Publications for KCTD10 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study. (PMID: 20570916) Keebler ME … Kathiresan S (Circulation. Cardiovascular genetics 2010) 3 45 60
  3. Common variants at 30 loci contribute to polygenic dyslipidemia. (PMID: 19060906) Kathiresan S … Cupples LA (Nature genetics 2009) 3 45 60
  4. KCTD10 interacts with proliferating cell nuclear antigen and its down-regulation could inhibit cell proliferation. (PMID: 19125419) Wang Y … Hui R (Journal of cellular biochemistry 2009) 3 4 60
  5. Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study. (PMID: 19605566) Junyent M … Ordovás JM (The American journal of clinical nutrition 2009) 3 45 60

Products for KCTD10 Gene

Sources for KCTD10 Gene

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