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Aliases for KCTD10 Gene

Aliases for KCTD10 Gene

  • Potassium Channel Tetramerization Domain Containing 10 2 3
  • Potassium Channel Tetramerization Domain-Containing Protein 10 3 4
  • Potassium Channel Tetramerisation Domain Containing 10 2 3
  • BTB/POZ Domain-Containing Protein KCTD10 3 4
  • HBACURD3 3 4
  • BTB/POZ Domain-Containing Adapter For CUL3-Mediated RhoA Degradation Protein 3 3
  • MSTP028 3
  • BTBD28 3
  • ULRO61 3
  • ULR061 4

External Ids for KCTD10 Gene

Summaries for KCTD10 Gene

GeneCards Summary for KCTD10 Gene

KCTD10 (Potassium Channel Tetramerization Domain Containing 10) is a Protein Coding gene. Diseases associated with KCTD10 include methylmalonic acidemia. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is KCTD13.

UniProtKB/Swiss-Prot for KCTD10 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD10 Gene

Genomics for KCTD10 Gene

Genomic Location for KCTD10 Gene

Start:
109,448,655 bp from pter
End:
109,477,544 bp from pter
Size:
28,890 bases
Orientation:
Minus strand

Genomic View for KCTD10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCTD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD10 Gene

Regulatory Elements for KCTD10 Gene

Proteins for KCTD10 Gene

  • Protein details for KCTD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3F6-BACD3_HUMAN
    Recommended name:
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
    Protein Accession:
    Q9H3F6
    Secondary Accessions:
    • Q53HN2
    • Q59FV1
    • Q6PL47
    • Q96SU0

    Protein attributes for KCTD10 Gene

    Size:
    313 amino acids
    Molecular mass:
    35432 Da
    Quaternary structure:
    • Component of the BCR(BACURD3) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and RBX1. Interacts with DNA polymerase delta subunit 2/POLD2 (By similarity). Interacts with PCNA.
    SequenceCaution:
    • Sequence=BAB55188.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD92595.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KCTD10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCTD10 Gene

Proteomics data for KCTD10 Gene at MOPED

Post-translational modifications for KCTD10 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys25, Lys32, Lys58, and Lys171

No data available for DME Specific Peptides for KCTD10 Gene

Domains for KCTD10 Gene

Gene Families for KCTD10 Gene

HGNC:
  • BTBD :BTB/POZ domain containing

Protein Domains for KCTD10 Gene

UniProtKB/Swiss-Prot:

BACD3_HUMAN
Domain:
  • Contains 1 BTB (POZ) domain.:
    • Q9H3F6
Family:
  • Belongs to the BACURD family.:
    • Q9H3F6
genes like me logo Genes that share domains with KCTD10: view

Function for KCTD10 Gene

Molecular function for KCTD10 Gene

UniProtKB/Swiss-Prot Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

Gene Ontology (GO) - Molecular Function for KCTD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity ISS --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KCTD10: view
genes like me logo Genes that share phenotypes with KCTD10: view

miRNA for KCTD10 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KCTD10 Gene

Localization for KCTD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCTD10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCTD10 Gene COMPARTMENTS Subcellular localization image for KCTD10 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for KCTD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0031463 Cul3-RING ubiquitin ligase complex ISS --
GO:0036038 TCTN-B9D complex IEA --
genes like me logo Genes that share ontologies with KCTD10: view

Pathways for KCTD10 Gene

genes like me logo Genes that share pathways with KCTD10: view

UniProtKB/Swiss-Prot Q9H3F6-BACD3_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for KCTD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination ISS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD10: view

Transcripts for KCTD10 Gene

Unigene Clusters for KCTD10 Gene

Potassium channel tetramerisation domain containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - -
SP7: - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - - -
SP12: - - - - -
SP13: - - - -
SP14: - -

Relevant External Links for KCTD10 Gene

GeneLoc Exon Structure for
KCTD10
ECgene alternative splicing isoforms for
KCTD10

Expression for KCTD10 Gene

mRNA expression in normal human tissues for KCTD10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCTD10 Gene

SOURCE GeneReport for Unigene cluster for KCTD10 Gene Hs.524731

genes like me logo Genes that share expressions with KCTD10: view

Orthologs for KCTD10 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD10 36
  • 99.04 (n)
  • 99.68 (a)
cow
(Bos Taurus)
Mammalia KCTD10 36
  • 93.08 (n)
  • 99.36 (a)
KCTD10 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCTD10 36
  • 92.37 (n)
  • 100 (a)
KCTD10 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kctd10 36
  • 89.67 (n)
  • 98.08 (a)
Kctd10 16
Kctd10 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCTD10 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kctd10 36
  • 89.99 (n)
  • 98.08 (a)
chicken
(Gallus gallus)
Aves KCTD10 36
  • 83.81 (n)
  • 98.4 (a)
KCTD10 37
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7517 36
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd10 36
  • 77.74 (n)
  • 95.85 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7817 36
zebrafish
(Danio rerio)
Actinopterygii kctd10 36
  • 79.98 (n)
  • 94.57 (a)
kctd10 37
  • 95 (a)
OneToOne
wufb30g12 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006173 36
  • 69.09 (n)
  • 73.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10465 36
  • 63.35 (n)
  • 72.51 (a)
CG10465 37
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0281.5 37
  • 29 (a)
ManyToMany
B0281.6 37
  • 32 (a)
ManyToMany
C17F4.8 37
  • 29 (a)
ManyToMany
C40A11.2 37
  • 27 (a)
ManyToMany
C40A11.3 37
  • 29 (a)
ManyToMany
C40A11.4 37
  • 24 (a)
ManyToMany
C40A11.6 37
  • 33 (a)
ManyToMany
C40A11.7 37
  • 31 (a)
ManyToMany
D2045.8 36
  • 47.96 (n)
  • 40.56 (a)
D2045.8 37
  • 35 (a)
ManyToMany
F22E5.11 37
  • 21 (a)
ManyToMany
F22E5.12 37
  • 26 (a)
ManyToMany
F22E5.13 37
  • 17 (a)
ManyToMany
F22E5.6 37
  • 31 (a)
ManyToMany
F22E5.8 37
  • 24 (a)
ManyToMany
K02F6.5 37
  • 26 (a)
ManyToMany
K02F6.8 37
  • 25 (a)
ManyToMany
sdz-35 37
  • 31 (a)
ManyToMany
T05E12.3 37
  • 25 (a)
ManyToMany
T08G3.13 37
  • 27 (a)
ManyToMany
ZC239.13 37
  • 39 (a)
ManyToMany
ZC239.14 37
  • 30 (a)
ManyToMany
ZC239.15 37
  • 29 (a)
ManyToMany
ZC239.16 37
  • 35 (a)
ManyToMany
ZC239.17 37
  • 34 (a)
ManyToMany
ZC239.2 37
  • 24 (a)
ManyToMany
ZC239.3 37
  • 27 (a)
ManyToMany
ZC239.4 37
  • 27 (a)
ManyToMany
ZC239.5 37
  • 25 (a)
ManyToMany
ZC239.6 37
  • 24 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.106 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9320 37
  • 68 (a)
OneToMany
Species with no ortholog for KCTD10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD10 Gene

ENSEMBL:
Gene Tree for KCTD10 (if available)
TreeFam:
Gene Tree for KCTD10 (if available)

Paralogs for KCTD10 Gene

Paralogs for KCTD10 Gene

Pseudogenes.org Pseudogenes for KCTD10 Gene

genes like me logo Genes that share paralogs with KCTD10: view

Variants for KCTD10 Gene

Sequence variations from dbSNP and Humsavar for KCTD10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs14064 -- 109,450,760(+) GTGGA(C/G)TCGGG utr-variant-3-prime
rs918106 -- 109,466,513(-) CATTT(A/G)TGGAG intron-variant
rs918107 -- 109,466,393(-) TGATA(A/G)TGTTT intron-variant
rs1045857 -- 109,449,017(-) GTTTT(G/T)TTTGT utr-variant-3-prime
rs1073779 -- 109,456,916(+) GTTCC(C/T)AGAGA intron-variant

Relevant External Links for KCTD10 Gene

HapMap Linkage Disequilibrium report
KCTD10

No data available for Structural Variations from Database of Genomic Variants (DGV) for KCTD10 Gene

Disorders for KCTD10 Gene

(1) MalaCards Diseases for KCTD10 Gene

Search for KCTD10 Gene in MalaCards »

(1) University of Copenhagen DISEASES for KCTD10 Gene

Relevant External Links for KCTD10

Genetic Association Database (GAD)
KCTD10
Human Genome Epidemiology (HuGE) Navigator
KCTD10
genes like me logo Genes that share disorders with KCTD10: view

No data available for UniProtKB/Swiss-Prot for KCTD10 Gene

Publications for KCTD10 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  2. Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study. (PMID: 20570916) Keebler M.E. … Kathiresan S. (Circ Cardiovasc Genet 2010) 3 49
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for KCTD10 Gene

Sources for KCTD10 Gene

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