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Aliases for KCTD10 Gene

Aliases for KCTD10 Gene

  • Potassium Channel Tetramerization Domain Containing 10 2 3 5
  • Potassium Channel Tetramerization Domain-Containing Protein 10 3 4
  • Potassium Channel Tetramerisation Domain Containing 10 2 3
  • BTB/POZ Domain-Containing Protein KCTD10 3 4
  • HBACURD3 3 4
  • MSTP028 3
  • BTBD28 3
  • ULRO61 3
  • ULR061 4

External Ids for KCTD10 Gene

Previous GeneCards Identifiers for KCTD10 Gene

  • GC12M108349
  • GC12M109887
  • GC12M106904

Summaries for KCTD10 Gene

Entrez Gene Summary for KCTD10 Gene

  • The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for KCTD10 Gene

KCTD10 (Potassium Channel Tetramerization Domain Containing 10) is a Protein Coding gene. Diseases associated with KCTD10 include Gastrointestinal Stromal Tumor. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is KCTD14.

UniProtKB/Swiss-Prot for KCTD10 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD10 Gene

Genomics for KCTD10 Gene

Regulatory Elements for KCTD10 Gene

Enhancers for KCTD10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCTD10 on UCSC Golden Path with GeneCards custom track

Promoters for KCTD10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KCTD10 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCTD10 Gene

Chromosome:
12
Start:
109,448,655 bp from pter
End:
109,477,544 bp from pter
Size:
28,890 bases
Orientation:
Minus strand

Genomic View for KCTD10 Gene

Genes around KCTD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD10 Gene

Proteins for KCTD10 Gene

  • Protein details for KCTD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3F6-BACD3_HUMAN
    Recommended name:
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
    Protein Accession:
    Q9H3F6
    Secondary Accessions:
    • Q53HN2
    • Q59FV1
    • Q6PL47
    • Q96SU0

    Protein attributes for KCTD10 Gene

    Size:
    313 amino acids
    Molecular mass:
    35432 Da
    Quaternary structure:
    • Component of the BCR(BACURD3) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and RBX1. Interacts with DNA polymerase delta subunit 2/POLD2 (By similarity). Interacts with PCNA.
    SequenceCaution:
    • Sequence=BAB55188.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD92595.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KCTD10 Gene

    Alternative splice isoforms for KCTD10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCTD10 Gene

Proteomics data for KCTD10 Gene at MOPED

Post-translational modifications for KCTD10 Gene

  • Ubiquitination at Lys 25, Lys 32, and Lys 171
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KCTD10 Gene

Domains & Families for KCTD10 Gene

Gene Families for KCTD10 Gene

Protein Domains for KCTD10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H3F6

UniProtKB/Swiss-Prot:

BACD3_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Belongs to the BACURD family.
Domain:
  • Contains 1 BTB (POZ) domain.
Family:
  • Belongs to the BACURD family.
genes like me logo Genes that share domains with KCTD10: view

Function for KCTD10 Gene

Molecular function for KCTD10 Gene

UniProtKB/Swiss-Prot Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

Gene Ontology (GO) - Molecular Function for KCTD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity ISS --
genes like me logo Genes that share ontologies with KCTD10: view
genes like me logo Genes that share phenotypes with KCTD10: view

Animal Models for KCTD10 Gene

MGI Knock Outs for KCTD10:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCTD10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCTD10 Gene

Localization for KCTD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCTD10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCTD10 Gene COMPARTMENTS Subcellular localization image for KCTD10 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for KCTD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with KCTD10: view

Pathways & Interactions for KCTD10 Gene

genes like me logo Genes that share pathways with KCTD10: view

UniProtKB/Swiss-Prot Q9H3F6-BACD3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for KCTD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD10: view

No data available for SIGNOR curated interactions for KCTD10 Gene

Drugs & Compounds for KCTD10 Gene

No Compound Related Data Available

Transcripts for KCTD10 Gene

Unigene Clusters for KCTD10 Gene

Potassium channel tetramerisation domain containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - -
SP7: - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - - -
SP12: - - - - -
SP13: - - - -
SP14: - -

Relevant External Links for KCTD10 Gene

GeneLoc Exon Structure for
KCTD10
ECgene alternative splicing isoforms for
KCTD10

Expression for KCTD10 Gene

mRNA expression in normal human tissues for KCTD10 Gene

Protein differential expression in normal tissues from HIPED for KCTD10 Gene

This gene is overexpressed in Bone marrow stromal cell (49.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCTD10 Gene



SOURCE GeneReport for Unigene cluster for KCTD10 Gene Hs.524731

genes like me logo Genes that share expression patterns with KCTD10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KCTD10 Gene

Orthologs for KCTD10 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCTD10 35
  • 93.08 (n)
  • 99.36 (a)
KCTD10 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCTD10 35
  • 92.37 (n)
  • 100 (a)
KCTD10 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kctd10 35
  • 89.67 (n)
  • 98.08 (a)
Kctd10 16
Kctd10 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCTD10 35
  • 99.04 (n)
  • 99.68 (a)
rat
(Rattus norvegicus)
Mammalia Kctd10 35
  • 89.99 (n)
  • 98.08 (a)
oppossum
(Monodelphis domestica)
Mammalia KCTD10 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCTD10 35
  • 83.81 (n)
  • 98.4 (a)
KCTD10 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd10 35
  • 77.74 (n)
  • 95.85 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7517 35
zebrafish
(Danio rerio)
Actinopterygii kctd10 35
  • 79.98 (n)
  • 94.57 (a)
wufb30g12 35
kctd10 36
  • 95 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7817 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006173 35
  • 69.09 (n)
  • 73.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10465 35
  • 63.35 (n)
  • 72.51 (a)
CG10465 36
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea D2045.8 35
  • 47.96 (n)
  • 40.56 (a)
B0281.5 36
  • 29 (a)
ManyToMany
B0281.6 36
  • 32 (a)
ManyToMany
C17F4.8 36
  • 29 (a)
ManyToMany
C40A11.2 36
  • 27 (a)
ManyToMany
C40A11.3 36
  • 29 (a)
ManyToMany
C40A11.4 36
  • 24 (a)
ManyToMany
C40A11.6 36
  • 33 (a)
ManyToMany
C40A11.7 36
  • 31 (a)
ManyToMany
D2045.8 36
  • 35 (a)
ManyToMany
F22E5.11 36
  • 21 (a)
ManyToMany
F22E5.12 36
  • 26 (a)
ManyToMany
F22E5.13 36
  • 17 (a)
ManyToMany
F22E5.6 36
  • 31 (a)
ManyToMany
F22E5.8 36
  • 24 (a)
ManyToMany
K02F6.5 36
  • 26 (a)
ManyToMany
K02F6.8 36
  • 25 (a)
ManyToMany
sdz-35 36
  • 31 (a)
ManyToMany
T05E12.3 36
  • 25 (a)
ManyToMany
T08G3.13 36
  • 27 (a)
ManyToMany
ZC239.13 36
  • 39 (a)
ManyToMany
ZC239.14 36
  • 30 (a)
ManyToMany
ZC239.15 36
  • 29 (a)
ManyToMany
ZC239.16 36
  • 35 (a)
ManyToMany
ZC239.17 36
  • 34 (a)
ManyToMany
ZC239.2 36
  • 24 (a)
ManyToMany
ZC239.3 36
  • 27 (a)
ManyToMany
ZC239.4 36
  • 27 (a)
ManyToMany
ZC239.5 36
  • 25 (a)
ManyToMany
ZC239.6 36
  • 24 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.106 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9320 36
  • 68 (a)
OneToMany
Species with no ortholog for KCTD10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD10 Gene

ENSEMBL:
Gene Tree for KCTD10 (if available)
TreeFam:
Gene Tree for KCTD10 (if available)

Paralogs for KCTD10 Gene

Paralogs for KCTD10 Gene

Pseudogenes.org Pseudogenes for KCTD10 Gene

genes like me logo Genes that share paralogs with KCTD10: view

Variants for KCTD10 Gene

Sequence variations from dbSNP and Humsavar for KCTD10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1990714 -- 109,463,206(-) TTCCC(A/C)AGCAG intron-variant
rs1990715 -- 109,462,960(-) GAAAG(A/G)TAATA intron-variant
rs2058804 -- 109,471,206(-) TAACG(C/T)TTGTG intron-variant
rs14064 -- 109,450,760(+) GTGGA(C/G)TCGGG utr-variant-3-prime
rs7136048 -- 109,466,121(+) CTGCC(A/G)CAGTG intron-variant

Variation tolerance for KCTD10 Gene

Residual Variation Intolerance Score: 30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.92% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for KCTD10 Gene

Disorders for KCTD10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KCTD10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gastrointestinal stromal tumor
  • paraganglioma and gastric stromal sarcoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KCTD10

Genetic Association Database (GAD)
KCTD10
Human Genome Epidemiology (HuGE) Navigator
KCTD10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCTD10
genes like me logo Genes that share disorders with KCTD10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCTD10 Gene

Publications for KCTD10 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for KCTD10 Gene

Sources for KCTD10 Gene

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