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Aliases for KCTD10 Gene

Aliases for KCTD10 Gene

  • Potassium Channel Tetramerization Domain Containing 10 2 3 5
  • Potassium Channel Tetramerization Domain-Containing Protein 10 3 4
  • Potassium Channel Tetramerisation Domain Containing 10 2 3
  • BTB/POZ Domain-Containing Protein KCTD10 3 4
  • HBACURD3 3 4
  • BTB/POZ Domain-Containing Adapter For CUL3-Mediated RhoA Degradation Protein 3 3
  • MSTP028 3
  • BTBD28 3
  • ULRO61 3
  • ULR061 4

External Ids for KCTD10 Gene

Previous GeneCards Identifiers for KCTD10 Gene

  • GC12M108349
  • GC12M109887
  • GC12M106904

Summaries for KCTD10 Gene

Entrez Gene Summary for KCTD10 Gene

  • The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for KCTD10 Gene

KCTD10 (Potassium Channel Tetramerization Domain Containing 10) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is TNFAIP1.

UniProtKB/Swiss-Prot for KCTD10 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

Additional gene information for KCTD10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD10 Gene

Genomics for KCTD10 Gene

GeneHancer (GH) Regulatory Elements for KCTD10 Gene

Promoters and enhancers for KCTD10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I109475 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 576.7 +0.5 451 3 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 POLR2B KCTD10 UBE3B IFT81 ALKBH2 SART3 RNU4-32P FAM216A USP30 ARPC3 ANKRD13A
GH12I109571 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.1 -95.6 -95630 3.2 CLOCK DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D MVK MMAB RNU4-32P UBE3B KCTD10 GPN3 MYO1H GC12M109566
GH12I109457 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.1 +14.5 14527 11.2 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 TCF12 ZNF766 E2F8 ELK1 KCTD10 MYO1H TRPV4 UBE3B MVK ENSG00000255655
GH12I108514 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 17.4 +961.8 961842 2.3 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 POLR2B E2F8 ZNF143 FOS FICD PWP1 SART3 KCTD10 LOC101929162 ALKBH2 UBE3B ISCU GC12P108510 PIR52944
GH12I109878 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.1 -403.0 -402985 3.4 HDGF ARNT SIN3A ZNF2 ZBTB7B ZNF213 ZNF143 FOS NFYC ZHX2 GLTP ENSG00000249094 TCHP RNU4-32P KCTD10 IFT81 ANKRD13A PPP1CC FAM216A UBE3B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KCTD10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCTD10 gene promoter:

Genomic Locations for KCTD10 Gene

Genomic Locations for KCTD10 Gene
28,890 bases
Minus strand

Genomic View for KCTD10 Gene

Genes around KCTD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD10 Gene

Proteins for KCTD10 Gene

  • Protein details for KCTD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
    Protein Accession:
    Secondary Accessions:
    • Q53HN2
    • Q59FV1
    • Q6PL47
    • Q96SU0

    Protein attributes for KCTD10 Gene

    313 amino acids
    Molecular mass:
    35432 Da
    Quaternary structure:
    • Homotetramer; forms a two-fold symmetric tetramer in solution (PubMed:28963344). Interacts with CUL3; interaction is direct and forms a 5:5 heterodecamer (PubMed:28963344). Component of the BCR(BACURD3) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and RBX1 (By similarity). Interacts with DNA polymerase delta subunit 2/POLD2 (By similarity). Interacts with PCNA (PubMed:19125419).
    • Sequence=BAB55188.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD92595.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KCTD10 Gene

    Alternative splice isoforms for KCTD10 Gene


neXtProt entry for KCTD10 Gene

Post-translational modifications for KCTD10 Gene

  • Ubiquitination at isoforms=225, isoforms=232, and posLast=171171

No data available for DME Specific Peptides for KCTD10 Gene

Domains & Families for KCTD10 Gene

Gene Families for KCTD10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KCTD10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BACURD family.
  • Belongs to the BACURD family.
genes like me logo Genes that share domains with KCTD10: view

Function for KCTD10 Gene

Molecular function for KCTD10 Gene

UniProtKB/Swiss-Prot Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

Phenotypes From GWAS Catalog for KCTD10 Gene

Gene Ontology (GO) - Molecular Function for KCTD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity ISS --
GO:0005112 Notch binding IPI 25401743
GO:0005515 protein binding IPI 19615732
genes like me logo Genes that share ontologies with KCTD10: view
genes like me logo Genes that share phenotypes with KCTD10: view

Animal Models for KCTD10 Gene

MGI Knock Outs for KCTD10:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCTD10 Gene

Localization for KCTD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCTD10 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD10 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KCTD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0031463 Cul3-RING ubiquitin ligase complex ISS --
genes like me logo Genes that share ontologies with KCTD10: view

Pathways & Interactions for KCTD10 Gene

genes like me logo Genes that share pathways with KCTD10: view

UniProtKB/Swiss-Prot Q9H3F6-BACD3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for KCTD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IDA 25401743
GO:0016567 protein ubiquitination ISS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD10: view

No data available for SIGNOR curated interactions for KCTD10 Gene

Drugs & Compounds for KCTD10 Gene

No Compound Related Data Available

Transcripts for KCTD10 Gene

Unigene Clusters for KCTD10 Gene

Potassium channel tetramerisation domain containing 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - -
SP7: - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - - -
SP12: - - - - -
SP13: - - - -
SP14: - -

Relevant External Links for KCTD10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCTD10 Gene

Protein differential expression in normal tissues from HIPED for KCTD10 Gene

This gene is overexpressed in Bone marrow stromal cell (49.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KCTD10 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCTD10 Gene:


SOURCE GeneReport for Unigene cluster for KCTD10 Gene:


Evidence on tissue expression from TISSUES for KCTD10 Gene

  • Nervous system(4.9)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with KCTD10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCTD10 Gene

Orthologs for KCTD10 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KCTD10 33
  • 99.04 (n)
(Bos Taurus)
Mammalia KCTD10 33 34
  • 93.08 (n)
(Canis familiaris)
Mammalia KCTD10 33 34
  • 92.37 (n)
(Monodelphis domestica)
Mammalia KCTD10 34
  • 91 (a)
(Rattus norvegicus)
Mammalia Kctd10 33
  • 89.99 (n)
(Mus musculus)
Mammalia Kctd10 33 16 34
  • 89.67 (n)
(Gallus gallus)
Aves KCTD10 33 34
  • 83.81 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd10 33
  • 77.74 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7517 33
(Danio rerio)
Actinopterygii kctd10 33 34
  • 79.98 (n)
wufb30g12 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7817 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006173 33
  • 69.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10465 33 34
  • 63.35 (n)
(Caenorhabditis elegans)
Secernentea D2045.8 33 34
  • 47.96 (n)
ZC239.13 34
  • 39 (a)
ZC239.16 34
  • 35 (a)
ZC239.17 34
  • 34 (a)
C40A11.6 34
  • 33 (a)
B0281.6 34
  • 32 (a)
C40A11.7 34
  • 31 (a)
F22E5.6 34
  • 31 (a)
sdz-35 34
  • 31 (a)
ZC239.14 34
  • 30 (a)
B0281.5 34
  • 29 (a)
C17F4.8 34
  • 29 (a)
C40A11.3 34
  • 29 (a)
ZC239.15 34
  • 29 (a)
C40A11.2 34
  • 27 (a)
T08G3.13 34
  • 27 (a)
ZC239.3 34
  • 27 (a)
ZC239.4 34
  • 27 (a)
F22E5.12 34
  • 26 (a)
K02F6.5 34
  • 26 (a)
K02F6.8 34
  • 25 (a)
T05E12.3 34
  • 25 (a)
ZC239.5 34
  • 25 (a)
C40A11.4 34
  • 24 (a)
F22E5.8 34
  • 24 (a)
ZC239.2 34
  • 24 (a)
ZC239.6 34
  • 24 (a)
F22E5.11 34
  • 21 (a)
F22E5.13 34
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9320 34
  • 68 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.106 33
Species where no ortholog for KCTD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD10 Gene

Gene Tree for KCTD10 (if available)
Gene Tree for KCTD10 (if available)

Paralogs for KCTD10 Gene

Paralogs for KCTD10 Gene Pseudogenes for KCTD10 Gene

genes like me logo Genes that share paralogs with KCTD10: view

Variants for KCTD10 Gene

Sequence variations from dbSNP and Humsavar for KCTD10 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000597960 -- 109,479,487(-) G/A upstream_transcript_variant
rs1000656628 -- 109,450,270(-) T/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000721947 -- 109,462,620(-) G/A intron_variant
rs1000794545 -- 109,462,279(-) T/A intron_variant
rs1000805943 -- 109,473,666(-) C/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD10 Gene

Variant ID Type Subtype PubMed ID
esv3580463 CNV loss 25503493

Variation tolerance for KCTD10 Gene

Residual Variation Intolerance Score: 30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCTD10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD10 Gene

Disorders for KCTD10 Gene

Additional Disease Information for KCTD10

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KCTD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD10 Gene

Publications for KCTD10 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study. (PMID: 20570916) Keebler ME … Kathiresan S (Circulation. Cardiovascular genetics 2010) 3 44 58
  3. Common variants at 30 loci contribute to polygenic dyslipidemia. (PMID: 19060906) Kathiresan S … Cupples LA (Nature genetics 2009) 3 44 58
  4. Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study. (PMID: 19605566) Junyent M … Ordovás JM (The American journal of clinical nutrition 2009) 3 44 58
  5. KCTD10 interacts with proliferating cell nuclear antigen and its down-regulation could inhibit cell proliferation. (PMID: 19125419) Wang Y … Hui R (Journal of cellular biochemistry 2009) 3 4 58

Products for KCTD10 Gene

Sources for KCTD10 Gene

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