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KCTD10 Gene

protein-coding   GIFtS: 50
GCID: GC12M109887

Potassium Channel Tetramerization Domain Containing 10

(Previous name: potassium channel tetramerisation domain containing 10)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Channel Tetramerization Domain Containing 101 2     BTBD282
Potassium Channel Tetramerisation Domain Containing 101 2     ULRO612
Potassium Channel Tetramerization Domain-Containing Protein 102 3     BTB/POZ Domain-Containing Adapter For CUL3-Mediated RhoA Degradation
Protein 32
BTB/POZ Domain-Containing Protein KCTD102 3     ULR0613
hBACURD32 3     

External Ids:    HGNC: 232361   Entrez Gene: 838922   Ensembl: ENSG000001109067   OMIM: 6134215   UniProtKB: Q9H3F63   

Export aliases for KCTD10 gene to outside databases

Previous GC identifers: GC12M108349 GC12M106904


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KCTD10 Gene:
KCTD10 (potassium channel tetramerization domain containing 10) is a protein-coding gene. Diseases associated with KCTD10 include methylmalonic acidemia, and maturity-onset diabetes of the young. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is TNFAIP1.

UniProtKB/Swiss-Prot: BACD3_HUMAN, Q9H3F6
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The
BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their
degradation by the proteasome (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCTD10 gene promoter:
         HOXA3   GCNF-1   GCNF   GCNF-2   Nkx5-1   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCTD10 promoter sequence
   Search Chromatin IP Primers for KCTD10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCTD10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.11   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24.12

KCTD10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCTD10 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M109887:  view genomic region     (about GC identifiers)

Start:
109,886,460 bp from pter      End:
109,915,349 bp from pter
Size:
28,890 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BACD3_HUMAN, Q9H3F6 (See protein sequence)
Recommended Name: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3  
Size: 313 amino acids; 35432 Da
Subunit: Component of the BCR(BACURD3) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and
RBX1. Interacts with DNA polymerase delta subunit 2/POLD2 (By similarity). Interacts with PCNA
Sequence caution: Sequence=BAB55188.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAD92595.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q53HN2 Q59FV1 Q6PL47 Q96SU0
Alternative splicing: 3 isoforms:  Q9H3F6-1   Q9H3F6-2   Q9H3F6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KCTD10: NX_Q9H3F6

Explore proteomics data for KCTD10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys25, Lys32, Lys58, Lys171
  • Modification sites at PhosphoSitePlus

  • See KCTD10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_114160.1  
    ENSEMBL proteins: 
     ENSP00000228495   ENSP00000439722   ENSP00000390321   ENSP00000474497   ENSP00000441672  
     ENSP00000439481   ENSP00000441586   ENSP00000440008   ENSP00000474870   ENSP00000437348  
     ENSP00000445129   ENSP00000411279  

    KCTD10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for KCTD10
    OriGene Protein Over-expression Lysate for KCTD10
    OriGene MassSpec for KCTD10
    OriGene Custom Protein Services for KCTD10
    GenScript Custom Purified and Recombinant Proteins Services for KCTD10
    Novus Biologicals KCTD10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KCTD10

    KCTD10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KCTD10
    Novus Biologicals KCTD10 Antibodies
    Abcam antibodies for KCTD10
    Cloud-Clone Corp. Antibodies for KCTD10
    Search ThermoFisher Antibodies for KCTD10
    LSBio Antibodies in human, mouse, rat for KCTD10

    KCTD10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for KCTD10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KCTD10
    Cloud-Clone Corp. CLIAs for KCTD10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing

    3 InterPro protein domains:
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003131 T1-type_BTB

    Graphical View of Domain Structure for InterPro Entry Q9H3F6

    ProtoNet protein and cluster: Q9H3F6

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: BACD3_HUMAN, Q9H3F6
    Similarity: Belongs to the BACURD family
    Similarity: Contains 1 BTB (POZ) domain


    KCTD10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BACD3_HUMAN, Q9H3F6
    Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The
    BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their
    degradation by the proteasome (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity ISS--
    GO:0005515protein binding ----
         
    KCTD10 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for KCTD10:
     Cell division defect  Decreased viability of wild-ty  Increased G2M DNA content, inc  Increased cell death HMECs cel 
     Increased gamma-H2AX phosphory  Increased number of mitotic ce 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kctd10):
     behavior/neurological  limbs/digits/tail  mortality/aging  nervous system  skeleton 

    KCTD10 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCTD10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KCTD10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCTD10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCTD10

    miRNA
    Products:
        
    miRTarBase miRNAs that target KCTD10:
    hsa-mir-375 (MIRT019854), hsa-mir-130b-3p (MIRT020169), hsa-mir-193b-3p (MIRT041231), hsa-mir-19b-3p (MIRT031145)

    Block miRNA regulation of human, mouse, rat KCTD10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCTD10 (see all 45):
    hsa-miR-596 hsa-miR-3607-3p hsa-let-7d hsa-miR-766 hsa-miR-3921 hsa-let-7g hsa-miR-9 hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidKCTD10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KCTD10
    Predesigned siRNA for gene silencing in human, mouse, rat KCTD10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KCTD10

    Clone
    Products:
         
    OriGene clones in human, mouse for KCTD10 (see all 9)
    OriGene ORF clones in mouse, rat for KCTD10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCTD10 (NM_031954)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCTD10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KCTD10
    Browse ESI BIO Cell Lines and PureStem Progenitors for KCTD10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BACD3_HUMAN, Q9H3F6: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0031463Cul3-RING ubiquitin ligase complex ISS--
    GO:0036038TCTN-B9D complex IEA--

    KCTD10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCTD10 About    
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37
    Cellular Effects of Sildenafil0.46
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    4Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    MODY (Maturity-Onset Diabetes of Young)0.41

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KCTD10 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling


    UniProtKB/Swiss-Prot: BACD3_HUMAN, Q9H3F6
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including KCTD10: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for KCTD10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for KCTD10 (Q9H3F63 ENSP000002284954) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN3P542523, ENSP000003523244I2D: score=2 STRING: ENSP00000352324
    RHOBP627453, ENSP000002722334I2D: score=2 STRING: ENSP00000272233
    USP13Q929953, ENSP000002639664I2D: score=2 STRING: ENSP00000263966
    KCTD13Q8WZ193, ENSP000003112024I2D: score=2 STRING: ENSP00000311202
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination ISS--
    GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process ISS--
    GO:0051260protein homooligomerization IEA--

    KCTD10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KCTD10 (BACD3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KCTD10 gene: 
    NM_031954.3  

    Unigene Cluster for KCTD10:

    Potassium channel tetramerisation domain containing 10
    Hs.524731  [show with all ESTs]
    Unigene Representative Sequence: AB209358
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228495(uc001toh.1 uc009zvi.1 uc001toi.1 uc001toj.1 uc001tok.1)
    ENST00000540089 ENST00000545759 ENST00000440541 ENST00000537165 ENST00000538161
    ENST00000540411 ENST00000542954 ENST00000535546 ENST00000540402 ENST00000540355
    ENST00000541077 ENST00000542262 ENST00000542858 ENST00000535747 ENST00000538377
    ENST00000424763
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KCTD10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCTD10 (see all 45):
    hsa-miR-596 hsa-miR-3607-3p hsa-let-7d hsa-miR-766 hsa-miR-3921 hsa-let-7g hsa-miR-9 hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidKCTD10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KCTD10
    Predesigned siRNA for gene silencing in human, mouse, rat KCTD10
    Clone
    Products:
         
    OriGene clones in human, mouse for KCTD10 (see all 9)
    OriGene ORF clones in mouse, rat for KCTD10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCTD10 (NM_031954)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCTD10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCTD10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KCTD10
    OriGene qSTAR qPCR primer pairs in human, mouse for KCTD10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCTD10
      QuantiTect SYBR Green Assays in human, mouse, rat KCTD10
      QuantiFast Probe-based Assays in human, mouse, rat KCTD10

    Additional mRNA sequence: 

    AB209358.1 AF113208.1 AK027543.1 AK056912.1 AK092170.1 AK123733.1 AK222548.1 AK309783.1 
    AY205299.1 AY597809.1 BC040062.1 

    17 DOTS entries:

    DT.100697129  DT.92441920  DT.121205019  DT.100776522  DT.101982654  DT.415777  DT.99967716  DT.100787976 
    DT.91639325  DT.97844544  DT.100668788  DT.121205005  DT.121205107  DT.75171382  DT.95261473  DT.97766730 
    DT.100787981 

    Selected AceView cDNA sequences (see all 263):

    BM697032 AL602829 AW513340 AI419806 AI190031 CA422463 BU740664 BE899166 
    R83619 AI830403 BP379089 CR596034 BM817555 CD368896 BQ056974 AI446411 
    BM834500 CD368542 AK123733 AI811504 CA422149 BU615561 AI066669 BU850192 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KCTD10 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d · 11e
    SP1:                    -     -           -           -     -     -     -                                                                                       
    SP2:                                      -           -     -     -     -                                                                                       
    SP3:                    -     -           -           -     -     -     -     -                                                                                 
    SP4:                                      -           -     -     -     -                             -                                                         
    SP5:                    -     -           -           -     -     -     -                                                                                       


    ECgene alternative splicing isoforms for KCTD10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCTD10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KCTD10 Expression
    About this image

    KCTD10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCTD10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524731
        Pathway & Disease-focused RT2 Profiler PCR Array including KCTD10: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KCTD10
    OriGene qSTAR qPCR primer pairs in human, mouse for KCTD10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCTD10
    QuantiTect SYBR Green Assays in human, mouse, rat KCTD10
    QuantiFast Probe-based Assays in human, mouse, rat KCTD10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KCTD10 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kctd101 , 5 potassium channel tetramerisation domain containing more1, 5 89.67(n)1
    98.08(a)1
      5 (55.99 cM)5
    3301711  NM_001159941.11  NP_001153413.11 
     1143635675 
    chicken
    (Gallus gallus)
    Aves KCTD101 potassium channel tetramerisation domain containing more 83.81(n)
    98.4(a)
      416900  XM_004945619.1  XP_004945676.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.75172 Xenopus laevis transcribed sequence with strong similarity more 78.32(n)    BU900731.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb30g122 Danio rerio cDNA clone MGC63846 IMAGE3817604, complete more 80.36(n)    BC061457.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG104651 CG10465 63.35(n)
    72.51(a)
      35488  NM_136321.3  NP_610165.1 
    worm
    (Caenorhabditis elegans)
    Secernentea D2045.81 D2045.8 47.96(n)
    40.56(a)
      176468  NM_066911.5  NP_499312.2 


    ENSEMBL Gene Tree for KCTD10 (if available)
    TreeFam Gene Tree for KCTD10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCTD10 gene
    TNFAIP12  KCTD132  
    6 SIMAP similar genes for KCTD10 using alignment to 12 protein entries:     BACD3_HUMAN (see all proteins):
    KCTD13    TNFAIP1    KCTD21    KCTD6    SHKBP1    KCTD17

    KCTD10 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KCTD10
    PGOHUM00000235998


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCTD10 (see all 578)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs346509131,2
    C--106906164(+) AGGGGCCG/-CCACC 1 -- ut311Minor allele frequency- -:0.50NA 2
    rs1392931571,2
    --109886711(+) TGGGGA/TCCCCA 1 -- ut310--------
    rs1932863641,2
    --109886714(+) GGTCCC/GCACAC 1 -- ut310--------
    rs1432156911,2
    C--109886727(+) TGATCA/GCCCCA 1 -- ut310--------
    rs722225151,2
    C--109886807(+) ATTTG-/AAAC  
            
    AAACA
    1 -- ut310--------
    rs583835621,2
    C--109886818(+) ACAAA-/C/CAAA
            
    AAAAA
    2 -- ut31 cds10--------
    rs10458571,2
    C,F--109886822(-) GTTTTT/GTTTGT 1 -- ut314Minor allele frequency- G:0.04MN WA NA EA 542
    rs749901071,2
    C,F--109886830(+) AACCCT/CTGATT 1 -- ut312Minor allele frequency- C:0.05WA NA 238
    rs1509387161,2
    C--109886872(+) AACTG-/TAGT  
            
    TAGTT
    1 -- ut310--------
    rs575452861,2
    C--109886874(+) AGTTA-/GTTA  
            
    TTACA
    1 -- ut310--------

    HapMap Linkage Disequilibrium report for KCTD10 (109886460 - 109915349 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KCTD10: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCTD10
    DNA2.0 Custom Variant and Variant Library Synthesis for KCTD10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613421    OMIM disorders: --

    7 diseases for KCTD10:    
    About MalaCards
    methylmalonic acidemia    maturity-onset diabetes of the young    cholera    coronary artery disease
    hepatitis    malaria    neuronitis

    1 disease from the University of Copenhagen DISEASES database for KCTD10:
    Methylmalonic acidemia

    KCTD10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KCTD10
    Human Genome Epidemiology (HuGE) Navigator: KCTD10 (4 documents)

    Export disorders for KCTD10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCTD10 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with KCTD10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study. (PubMed id 20570916)1, 4 Keebler M.E....Kathiresan S. (Circ Cardiovasc Genet 2010)
    3. Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)1, 4 Kathiresan S....Cupples L.A. (Nat. Genet. 2009)
    4. Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study. (PubMed id 19605566)1, 4 Junyent M....OrdovA!s J.M. (Am. J. Clin. Nutr. 2009)
    5. KCTD10 interacts with proliferating cell nuclear antigen and its down-regulation could inhibit cell proliferation. (PubMed id 19125419)1, 2 Wang Y.... Hui R. (J. Cell. Biochem. 2009)
    6. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. (PubMed id 18193043)1, 4 Willer C.J....Abecasis G.R. (Nat. Genet. 2008)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Proteomic investigation of the interactome of FMNL1 in hematopoietic cells unveils a role in calcium-dependent membrane plasticity. (PubMed id 23182705)1 Han Y....Krackhardt A.M. (J Proteomics 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83892 HGNC: 23236 AceView: KCTD10 Ensembl:ENSG00000110906 euGenes: HUgn83892
    ECgene: KCTD10 H-InvDB: KCTD10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCTD10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCTD10 gene:
    Search GeneIP for patents involving KCTD10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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