KCTD1 Gene
protein-coding GIFtS : 45 GCID: GC18 M024034
potassium channel tetramerisation domain containing 1 C18orf5 )
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Aliasesfor KCTD1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Potassium Channel Tetramerisation Domain Containing 1 1 2 C18orf51 2 3 Potassium Channel Tetramerization Domain-Containing Protein 12 3 BTB/POZ Domain-Containing Protein KCTD12
Export aliases for KCTD1 gene to outside databases Previous GC identifers: GC18U990074 GC18M022286 GC18M022288 GC18M020884
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Summariesfor KCTD1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: KCTD1_HUMAN, Q719H9 Function : May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C tovarious extent
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Genomic Viewsfor KCTD1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000018.9 NC_018929.1 NT_010966.14 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KCTD1 gene promoter:E2F-4 E2F-3a E2F E2F-1 E2F-2 Other transcription factors Search SABiosciences Chromatin IP Primers for KCTD1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 18q11.2 Ensembl cytogenetic band: 18q11.2 HGNC chromosome: 18 KCTD1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 18 GeneLoc Exon Structure
GeneLoc location for GC18M024034: view genomic region
(about GC identifiers )
Start: 24,034,874 bp from pter End:
24,237,365 bp from pter
Size: 202,492 bases Orientation:
minus strand
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Proteinsfor KCTD1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: KCTD1_HUMAN, Q719H9 See
protein sequence )Recommended Name: Size : 257 amino acids; 29405 DaSubunit : Can form homodimers. Interacts with TFAP2A, TFAP2B and TFAP2C via the BTB domainSubcellular location : NucleusSecondary accessions : A8K1F5Explore the universe of human proteins at neXtProt for KCTD1: NX_Q719H9 Post-translational modifications:
Sumoylated1 View neXtProt modification sites for NX_Q719H9 KCTD1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (5 alternative transcripts): NP_001129677.1 NP_001136202.1 NP_001245150.1 NP_001245151.1 NP_945342.1 ENSEMBL proteins: ENSP00000464170 ENSP00000384367 ENSP00000463041 ENSP00000464261 ENSP00000462470 ENSP00000463608 ENSP00000408405 ENSP00000314831 Human Recombinant Protein Products for KCTD1: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
About GeneDecksing KCTD1 Antibody Products: Assay Products for KCTD1:
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Protein
Domains /for KCTD1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q719H9 ProtoNet protein and cluster: Q719H9
UniProtKB/Swiss-Prot: KCTD1_HUMAN, Q719H9 Similarity : Contains 1 BTB (POZ) domain
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Functionfor KCTD1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: KCTD1_HUMAN, Q719H9 Function : May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C tovarious extent
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing Animal Models: Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat see all 4 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KCTD1 (NM_020768 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCTD1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat KCTD1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD1
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Pathways & Interactionsfor KCTD1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Sweet Taste Signaling 2 Activation of cAMP-Dependent PKA 3 Neuropathic Pain-Signaling in Dorsal Horn Neurons 4 Hepatic ABC Transporters
5/13 (see all 13 )Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCTD1 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for KCTD1 (ENSP00000408405 4 via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006351 transcription, DNA-dependent
IEA -- GO:0045892 negative regulation of transcription, DNA-dependent
IDA 19115315 GO:0051260 protein homooligomerization
IEA --
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Drugs & Compoundsfor KCTD1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for KCTD1 KCTD1
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Transcriptsfor KCTD1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for KCTD1 gene (5 alternative transcripts): NM_001136205.2 NM_001142730.2 NM_001258221.1 NM_001258222.1 NM_198991.3 Unigene Cluster for KCTD1:
Potassium channel tetramerisation domain containing 1 Hs.526630 [show with all ESTs ] Unigene Representative Sequence: NM_001142730 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000579973 (uc010xbk.2 ) ENST00000408011 (uc002kvw.3 ) ENST00000580059 ENST00000577255 (uc002kvy.3 ) ENST00000580191 ENST00000582494 ENST00000580638 ENST00000578973 ENST00000584630 ENST00000417602 (uc010xbj.2 ) ENST00000317932 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat see all 4 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KCTD1 (NM_020768 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCTD1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat KCTD1
Additional cDNA sequence: AF542549.1 AK289870.1 BC042371.1 BC063652.1
9 DOTS entries : DT.97838075 DT.440974
DT.101980382 DT.100775314 DT.100812415 DT.100812413 DT.99953009 DT.409420 DT.95268967 24/122 AceView cDNA sequences (see all 122 ):
AW025414 BQ233593 AA447957 BU527076 BU726041 AW296378 AI241933 BQ574512 AA400768 BG697890 AI769180 BM701104 BQ129255 AA384799 CR604274 AI985435 BM821563 BM713653 W74069 CB984664 W79380 AI478478 BU153387 AI298222 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KCTD1 (see all 7 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b SP1 : - - - - - - - SP2 : - - - - - SP3 : - SP4 : - - - - SP5 : -
ECgene alternative splicing isoforms for KCTD1
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Expression for KCTD1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section KCTD1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: -- About this image KCTD1 expression in embryonic tissues and stem cells About this table
See KCTD1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KCTD1 SOURCE GeneReport for Unigene cluster: Hs.526630 UniProtKB/Swiss-Prot: KCTD1_HUMAN, Q719H9 Tissue specificity : Expressed in mammary gland, kidney, brain and ovarySABiosciences Custom PCR Arrays for KCTD1 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD1
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Orthologsfor KCTD1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for KCTD1 gene from 4/19 species (see all 19 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves KCTD11
potassium channel tetramerisation domain containing more
85.77(n) 91.81(a)
421087 XM_001231830.2 XP_001231831.2
lizard Reptilia KCTD16
--
89(a)
1 ↔ 1
4(36669709-36695012)
zebrafish Actinopterygii kctd16
potassium channel tetramerisation domain containin... 80(a)
1 ↔ 1
20(18255812-18302230)
fruit fly Insecta CG104406
--
36(a)
1 → many
2R(17447751-17463540)
ENSEMBL Gene Tree for KCTD1 (if available)TreeFam Gene Tree for KCTD1 (if available)
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Paralogsfor KCTD1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for KCTD1 gene KCTD15 2 KCTD8 2 KCTD16 2 KCTD4 2 KCNRG 2 KCTD11 2 KCTD12 2 KCTD21 2 KCTD6 2 KCTD14 2 5 SIMAP similar genes for KCTD1 using alignment to 5 protein entries: KCTD1_HUMAN (see all proteins ):KCTD15 KCTD21 KCTD6 KCTD17 KCTD19 About GeneDecksing 1 Pseudogenes.org Pseudogene for KCTD1 PGOHUM00000263241
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Genomic Variantsfor KCTD1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 18 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for KCTD1 (24034874 - 24237365 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for KCTD1 1 Indel 41286
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor KCTD1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About MalaCards About GeneDecksing OMIM gene information: 613420
OMIM disorders : --Human Genome Epidemiology (HuGE) Navigator: KCTD1 (1 document)Export disorders for KCTD1 gene to outside databases
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Publicationsfor KCTD1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for KCTD1 gene, integrated from 9 sources (see all 16 ):(articles sorted by number of sources associating them with KCTD1) Utopia : connect your pdf to the dynamic
The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation. (PubMed id 19115315) 1 , 2 (2009) Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718) 1 , 2 (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) GWAS for discovery and replication of genetic loci as sociated with sudden cardiac arrest in patients with coronary artery disease. (PubMed id 21658281) 1 (2011) Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764) 1 (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 (2010) System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022) 1 (2009) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 (2008) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 (2007) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 (2006)
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External Searches for KCTD1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing KCTD1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing KCTD1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing KCTD1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for KCTD1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for KCTD1 gene: KCTD1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor KCTD1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for KCTD1 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for KCTD1 Browse OriGene Fluorogenic Cell Assay Kits Browse OriGene siRNAs OriGene 3'-UTR Clone for KCTD1 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for KCTD1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for KCTD1 OriGene Custom Protein Services for KCTD1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCTD1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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KCTD1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCTD1
ThermoFisher Antibodies for KCTD1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat KCTD1
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Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
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