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Aliases for KCP Gene

Aliases for KCP Gene

  • Kielin/Chordin-Like Protein 2 3 5
  • Cysteine Rich BMP Regulator 2 (Chordin-Like) 2 3
  • Cysteine-Rich Motor Neuron 2 Protein 3 4
  • Cysteine-Rich BMP Regulator 2 3 4
  • Kielin/Chordin-Like Protein 1 3 4
  • Kielin 2 3
  • CRIM-2 3 4
  • CRIM2 3 4
  • KCP-1 3 4
  • KCP1 3 4
  • NET67 3

External Ids for KCP Gene

Previous HGNC Symbols for KCP Gene

  • CRIM2

Previous GeneCards Identifiers for KCP Gene

  • GC07Mg27914
  • GC07M128503
  • GC07M122878

Summaries for KCP Gene

GeneCards Summary for KCP Gene

KCP (Kielin/Chordin-Like Protein) is a Protein Coding gene. An important paralog of this gene is CRIM1.

UniProtKB/Swiss-Prot for KCP Gene

  • Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCP Gene

Genomics for KCP Gene

Regulatory Elements for KCP Gene

Enhancers for KCP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCP on UCSC Golden Path with GeneCards custom track

Genomic Location for KCP Gene

128,862,451 bp from pter
128,910,719 bp from pter
48,269 bases
Minus strand

Genomic View for KCP Gene

Genes around KCP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCP Gene

Proteins for KCP Gene

  • Protein details for KCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kielin/chordin-like protein
    Protein Accession:
    Secondary Accessions:
    • Q8NBE0

    Protein attributes for KCP Gene

    1503 amino acids
    Molecular mass:
    159938 Da
    Quaternary structure:
    • Interacts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic serine/threonine protein kinase domains. Also able to interact with activin-A and TGFB1 (By similarity).

    Alternative splice isoforms for KCP Gene


neXtProt entry for KCP Gene

Proteomics data for KCP Gene at MOPED

Post-translational modifications for KCP Gene

  • Glycosylation at Asn 278
  • Modification sites at PhosphoSitePlus

Other Protein References for KCP Gene

Antibody Products

No data available for DME Specific Peptides for KCP Gene

Domains & Families for KCP Gene

Protein Domains for KCP Gene

Suggested Antigen Peptide Sequences for KCP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 TIL (trypsin inhibitory-like) domain.
  • Contains 1 TIL (trypsin inhibitory-like) domain.
  • Contains 17 VWFC domains.
  • Contains 1 VWFD domain.
genes like me logo Genes that share domains with KCP: view

No data available for Gene Families for KCP Gene

Function for KCP Gene

Molecular function for KCP Gene

UniProtKB/Swiss-Prot Function:
Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity).
genes like me logo Genes that share phenotypes with KCP: view

Animal Models for KCP Gene

MGI Knock Outs for KCP:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for KCP Gene

Localization for KCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCP Gene


No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for KCP Gene

Pathways & Interactions for KCP Gene

SuperPathways for KCP Gene

No Data Available

Interacting Proteins for KCP Gene

Selected Interacting proteins: Q6ZWJ8-KCP_HUMAN for KCP Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for KCP Gene


No data available for Pathways by source and SIGNOR curated interactions for KCP Gene

Drugs & Compounds for KCP Gene

No Compound Related Data Available

Transcripts for KCP Gene

mRNA/cDNA for KCP Gene

(16) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCP Gene

Kielin/chordin-like protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCP Gene

No ASD Table

Relevant External Links for KCP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCP Gene

mRNA expression in normal human tissues for KCP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCP Gene

This gene is overexpressed in Kidney - Cortex (x18.7), Brain - Cerebellum (x5.5), and Brain - Cerebellar Hemisphere (x5.3).

Protein differential expression in normal tissues from HIPED for KCP Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCP Gene

SOURCE GeneReport for Unigene cluster for KCP Gene Hs.371746

genes like me logo Genes that share expression patterns with KCP: view

Protein tissue co-expression partners for KCP Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for KCP Gene

Orthologs for KCP Gene

This gene was present in the common ancestor of mammals.

Orthologs for KCP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC515624 35
  • 86.3 (n)
  • 83.52 (a)
(Canis familiaris)
Mammalia KCP 35
  • 87.25 (n)
  • 85.5 (a)
(Mus musculus)
Mammalia Kcp 35
  • 81.37 (n)
  • 79.53 (a)
Kcp 16
(Pan troglodytes)
Mammalia LOC463713 35
  • 99.02 (n)
  • 98.34 (a)
(Rattus norvegicus)
Mammalia Kcp 35
  • 80.9 (n)
  • 79.17 (a)
Species with no ortholog for KCP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KCP Gene

Gene Tree for KCP (if available)
Gene Tree for KCP (if available)

Paralogs for KCP Gene

Paralogs for KCP Gene

(1) SIMAP similar genes for KCP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCP: view

Variants for KCP Gene

Sequence variations from dbSNP and Humsavar for KCP Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs7787221 - 128,908,505(+) AGTTC(C/T)CAGCA reference, missense
VAR_059625 -
VAR_059626 -
rs7786641 - 128,880,387(+) TCACG(C/G)GGCCA reference, missense
rs6948542 -- 128,907,459(+) CTGGA(A/G)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCP Gene

Variant ID Type Subtype PubMed ID
esv2735137 CNV Deletion 23290073
esv2670312 CNV Deletion 23128226
nsv831125 CNV Loss 17160897
esv22837 CNV Gain 19812545
nsv889192 CNV Loss 21882294
nsv517923 CNV Gain 19592680
nsv464713 CNV Loss 19166990
dgv7490n71 CNV Loss 21882294
nsv464715 CNV Loss 19166990
nsv464717 CNV Loss 19166990
nsv470392 CNV Gain 18288195
nsv517371 CNV Gain+Loss 19592680
dgv7491n71 CNV Loss 21882294
nsv5946 CNV Loss 18451855
esv2735145 CNV Deletion 23290073

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for KCP Gene

Disorders for KCP Gene

Relevant External Links for KCP

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KCP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCP Gene

Publications for KCP Gene

  1. Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. (PMID: 15793581) Lin J. … Dressler G.R. (Nat. Med. 2005) 2 3 67
  2. Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease. (PMID: 18446379) Zeisberg M. … Kalluri R. (Pediatr. Nephrol. 2008) 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for KCP Gene

Sources for KCP Gene