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KCP Gene

protein-coding   GIFtS: 47
GCID: GC07M128503

Kielin/Chordin-Like Protein

(Previous name: cysteine rich BMP regulator 2 (chordin-like))
(Previous symbol: CRIM2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kielin/Chordin-Like Protein1 2     Kielin/Chordin-Like Protein 12 3
CRIM21 2 3     CRIM-22 3
Cysteine Rich BMP Regulator 2 (Chordin-Like)1 2     KCP-12 3
kielin1 2     KCP12 3
Cysteine-Rich BMP Regulator 22 3     NET672
Cysteine-Rich Motor Neuron 2 Protein2 3     

External Ids:    HGNC: 175851   Entrez Gene: 3756162   Ensembl: ENSG000001352537   OMIM: 6093445   UniProtKB: Q6ZWJ83   

Export aliases for KCP gene to outside databases

Previous GC identifers: GC07Mg27914 GC07M122878


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KCP Gene:
KCP (kielin/chordin-like protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: KCP_HUMAN, Q6ZWJ8
Function: Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both
the activin-A and TGFB1-mediated signaling pathways (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCP gene promoter:
         AhR   p53   AP-1   ATF-2   c-Jun   Arnt   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KCP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32.1   Ensembl cytogenetic band:  7q32.1   HGNC cytogenetic band: 7q32.3

KCP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCP gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M128503:  view genomic region     (about GC identifiers)

Start:
128,502,505 bp from pter      End:
128,550,773 bp from pter
Size:
48,269 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 127,900,664-127,934,517     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCP_HUMAN, Q6ZWJ8 (See protein sequence)
Recommended Name: Kielin/chordin-like protein precursor  
Size: 1503 amino acids; 159938 Da
Subunit: Interacts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic
serine/threonine protein kinase domains. Also able to interact with activin-A and TGFB1 (By similarity)
Secondary accessions: Q8NBE0
Alternative splicing: 2 isoforms:  Q6ZWJ8-1   Q6ZWJ8-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for KCP: NX_Q6ZWJ8

Explore proteomics data for KCP at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn278

  • See KCP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129386.1  NP_955381.2  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR014853 Unchr_dom_Cys-rich
     IPR002919 TIL_dom
     IPR001007 VWF_C
     IPR001846 VWF_type-D

    Graphical View of Domain Structure for InterPro Entry Q6ZWJ8

    ProtoNet protein and cluster: Q6ZWJ8

    1 Blocks protein domain: IPB001007 von Willebrand factor

    UniProtKB/Swiss-Prot: KCP_HUMAN, Q6ZWJ8
    Similarity: Contains 1 TIL (trypsin inhibitory-like) domain
    Similarity: Contains 17 VWFC domains
    Similarity: Contains 1 VWFD domain


    Find genes that share domains with KCP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCP_HUMAN, Q6ZWJ8
    Function: Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both
    the activin-A and TGFB1-mediated signaling pathways (By similarity)

    Phenotypes:
         2 GenomeRNAi human phenotypes for KCP:

     Increased cell number in G2M,   Wnt reporter downregulated 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kcp):
     homeostasis/metabolism  mortality/aging  normal  renal/urinary system  skeleton 

    Find genes that share phenotypes with KCP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for KCP: Kcptm1Ysas Kcptm1Gdr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCP
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCP_HUMAN, Q6ZWJ8: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with KCP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCP
    Interactions:

        Search GeneGlobe Interaction Network for KCP

    1 Interacting protein for KCP (Q6ZWJ83) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMP7P180753I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KCP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCP gene (2 alternative transcripts): 
    NM_001135914.1  NM_199349.2  

    Unigene Cluster for KCP:

    Kielin/chordin-like protein
    Hs.371746  [show with all ESTs]
    Unigene Representative Sequence: NM_001135914
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492679(processed_transcript) ENST00000460528(processed_transcript) ENST00000476647(processed_transcript) ENST00000479474(processed_transcript) ENST00000487494(processed_transcript)
    ENST00000297801(processed_transcript) ENST00000441244(processed_transcript)
    miRNA
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    Additional mRNA sequence: AK122706.1 

    6 DOTS entries:

    DT.40196465  DT.91734406  DT.436571  DT.91678952  DT.40191760  DT.40283342 

    10 AceView cDNA sequences:

    AI245814 AI955614 NM_199349 AW296627 AK122706 BM921713 AK095464 AA635505 
    AI624849 BG166582 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAGTCACC
    KCP Expression
    About this image


    KCP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Cushion Mesenchymal Cells Endocardium
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
    KCP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.371746
        Custom PCR Arrays for KCP
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for KCP gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcp1 , 5 kielin/chordin-like protein1, 5 81.37(n)1
    79.53(a)1
      6 (12.36 cM)5
    3330881  NM_001029985.41  NP_001025156.31 
     294731625 


    ENSEMBL Gene Tree for KCP (if available)
    TreeFam Gene Tree for KCP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCP gene
    1 SIMAP similar gene for KCP using alignment to 1 protein entry:     KCP_HUMAN:
    MUC2

    Find genes that share paralogs with KCP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCP (see all 824)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476440691,2
    C--128516423(+) AGGGA-/TGTGT 
     GTTTCTG
    TGTGT
    1 -- cds10--------
    rs132388311,2
    C,F,A,H--128516470(+) CATTGT/CGGTCT 1 -- ds500119Minor allele frequency- C:0.33NS EA WA NA 2342
    rs286720681,2
    C,F--128516471(+) ATTGTG/AGTCTA 1 -- ds50013Minor allele frequency- A:0.20WA NA EA 358
    rs1814983971,2
    --128516476(+) GGTCTA/GTTGCT 1 -- ds50010--------
    rs2012043411,2
    C--128516555(+) CACAC-/CAGTAT 1 -- ds50010--------
    rs69522231,2
    C,F,H--128516733(+) CTCCTT/CCTACC 1 -- ds50019Minor allele frequency- C:0.12NS EA NA WA CSA 540
    rs1850497821,2
    --128516794(+) CAGGCA/TTGCAG 1 -- ds50010--------
    rs1902891021,2
    --128516876(+) GCCTCC/TGTCCC 1 -- ds50010--------
    rs15322221,2
    C,F,O,A,H--128516945(-) GTCACC/AAGCAG 1 -- ut3130Minor allele frequency- A:0.43NA MN NS EA WA CSA 2702
    rs782688461,2
    C--128517163(+) GTGAGC/TAGGAC 2 L syn10--------

    HapMap Linkage Disequilibrium report for KCP (128502505 - 128550773 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KCP (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735145CNV Deletion23290073
    esv2735137CNV Deletion23290073
    esv2670312CNV Deletion23128226
    nsv464715CNV Loss19166990
    nsv5946CNV Loss18451855
    dgv7491n71CNV Loss21882294
    nsv831125CNV Loss17160897
    nsv464713CNV Loss19166990
    nsv464717CNV Loss19166990
    dgv7490n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCP
    DNA2.0 Custom Variant and Variant Library Synthesis for KCP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609344    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for KCP:
    Kaposi's sarcoma

    Find genes that share disorders with KCP           About GenesLikeMe

    Genetic Association Database (GAD): KCP

    Export disorders for KCP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCP gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KCP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. (PubMed id 15793581)1, 3 Lin J....Dressler G.R. (Nat. Med. 2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)4 Anderson C.A....Rioux J.D. (Nat. Genet. 2011)
    4. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. (PubMed id 19838193)4 Han J.W....Zhang X.J. (Nat. Genet. 2009)
    5. Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease. (PubMed id 18446379)9 Zeisberg M. and Kalluri R. (Pediatr. Nephrol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 375616 HGNC: 17585 AceView: LOC375616 Ensembl:ENSG00000135253 euGenes: HUgn375616
    ECgene: KCP H-InvDB: KCP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCP gene:
    Search GeneIP for patents involving KCP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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