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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCP Gene

protein-coding   GIFtS: 45
GCID: GC07M128503

kielin/chordin-like protein

(Previous name: cysteine rich BMP regulator 2 (chordin-like) )
(Previous symbol: CRIM2)
 Explore 4 diseases affiliated with
KCP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCP    

Aliases
for KCP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Kielin/Chordin-Like Protein1 2     Kielin/Chordin-Like Protein 12 3
CRIM21 2 3     CRIM-22 3
NET671 2     KCP-12 3
Cysteine Rich BMP Regulator 2 (Chordin-Like)1 2     KCP12 3
Cysteine-Rich BMP Regulator 22 3     FLJ333651
Cysteine-Rich Motor Neuron 2 Protein2 3     Kielin1

External Ids:    HGNC: 175851   Entrez Gene: 3756162   Ensembl: ENSG000001352537   OMIM: 6093445   UniProtKB: Q6ZWJ83   

Export aliases for KCP gene to outside databases

Previous GC identifers: GC07Mg27914 GC07M122878


Summaries
for KCP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: KCP_HUMAN, Q6ZWJ8
Function: Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the
activin-A and TGFB1-mediated signaling pathways (By similarity)




Genomic Views
for KCP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCP gene promoter:
         AhR   p53   AP-1   ATF-2   c-Jun   Arnt   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KCP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32.1   Ensembl cytogenetic band:  7q32.1   HGNC cytogenetic band: 7q32.3

KCP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCP gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M128503:  view genomic region     (about GC identifiers)

Start:
 128,502,505 bp from pter      End:
 128,550,773 bp from pter
Size:
 48,269 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 127,900,664-127,934,517     

Proteins
for KCP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCP_HUMAN, Q6ZWJ8 (See protein sequence)
Recommended Name: Kielin/chordin-like protein precursor  
Size: 1503 amino acids; 159938 Da
Subunit: Interacts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic
serine/threonine protein kinase domains. Also able to interact with activin-A and TGFB1 (By similarity)
Subcellular location: Secreted (By similarity)
Secondary accessions: Q8NBE0
Alternative splicing: 2 isoforms:  Q6ZWJ8-1   Q6ZWJ8-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for KCP: NX_Q6ZWJ8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6ZWJ8

    • KCP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129386.1  NP_955381.2  

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    Uscn Proteins for KCP

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--


    KCP for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for KCP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCP for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR014853 Unchr_dom_Cys-rich
     IPR002919 TIL_dom
     IPR001007 VWF_C
     IPR001846 VWF_type-D

    Graphical View of Domain Structure for InterPro Entry Q6ZWJ8

    ProtoNet protein and cluster: Q6ZWJ8

    1 Blocks protein family: IPB001007 von Willebrand factor

    UniProtKB/Swiss-Prot: KCP_HUMAN, Q6ZWJ8
    Similarity: Contains 1 TIL (trypsin inhibitory-like) domain
    Similarity: Contains 17 VWFC domains
    Similarity: Contains 1 VWFD domain


    Function
    for KCP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCP_HUMAN, Q6ZWJ8
    Function: Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the
    activin-A and TGFB1-mediated signaling pathways (By similarity)

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    Inhib. RNA
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    2 GenomeRNAi human phenotypes for KCP:
     Increased cell number in G2M,   Wnt reporter downregulated 

    Animal Models:
         Mouse knock-outs for KCP: Kcptm1Ysas Kcptm1Gdr
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Kcp):
     homeostasis/metabolism  mortality/aging  normal  renal/urinary system  skeleton 

    KCP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KCP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCP

    1 Interacting protein for KCP (Q6ZWJ83) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMP7P180753I2D: score=1 
    About this table

    Drugs & Compounds
    for KCP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KCP
    Search CenterWatch for drugs/clinical trials and news about KCP 

    Transcripts
    for KCP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCP gene (2 alternative transcripts): 
    NM_001135914.1  NM_199349.2  

    Unigene Cluster for KCP:

    Kielin/chordin-like protein
    Hs.371746  [show with all ESTs]
    Unigene Representative Sequence: NM_001135914
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492679(uc003vob.1) ENST00000460528 ENST00000476647 ENST00000479474
    ENST00000487494(uc011kos.1) ENST00000297801 ENST00000441244(uc011kor.2)
    ENST00000257704 ENST00000545685

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    Inhib. RNA
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    OriGene siRNA: KCP
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    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCP

    Additional cDNA sequence: AK122706.1 

    6 DOTS entries:

    DT.40196465  DT.91734406  DT.436571  DT.91678952  DT.40191760  DT.40283342 

    10 AceView cDNA sequences:

    AA635505 AK095464 AI245814 BM921713 AI955614 NM_199349 AW296627 AK122706 
    AI624849 BG166582 

    GeneLoc Exon Structure


    Expression
    for KCP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGAGTCACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KCP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeInterscapular Brown Adipose DepotAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See KCP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCP

    SOURCE GeneReport for Unigene cluster: Hs.371746
        SABiosciences Custom PCR Arrays for KCP
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCP

    Orthologs
    for KCP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for KCP gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Kcp1 , 5 kielin/chordin-like protein1, 5 81.22(n)1
    79.38(a)1    		   6 (12.36 cM)5
    3330881  NM_001029985.41  NP_001025156.31 
     294731625 
    zebrafish
    (Danio rerio)    		 Actinopterygii si:dkey-266m15.61 si:dkey-266m15.6 51.19(n)
    43.76(a)    		   569039  XM_692402.5  XP_697494.5 


    ENSEMBL Gene Tree for KCP (if available)
    TreeFam Gene Tree for KCP (if available) 

    Paralogs
    for KCP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for KCP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/609 NCBI SNPs in KCP are shown (see all 609)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs356338441,2
    		C--127913720(+) CAGGC-/TTTTTTTT 1 -- ds50012Minor allele frequency- TTT:0.25NA 4
    rs2015021201,2
    		C--127913722(+) GGCTTC/TTTTTT 1 -- ds50010--------
    rs355220471,2
    		C--127920688(+) AAAAA-/ATTCCC 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1476440691,2
    		C,--128516423(+) AGGGA-/TGTGT 
     GTTTCTG    TGTGT     		1 -- ds50010--------
    rs132388311,2
    		C,F,A,H,--128516470(+) CATTGT/CGGTCT 1 -- ds500119Minor allele frequency- C:0.33NS EA WA NA 2342
    rs286720681,2
    		C,F,--128516471(+) ATTGTG/AGTCTA 1 -- ds50013Minor allele frequency- A:0.20WA NA EA 358
    rs1814983971,2
    		--128516476(+) GGTCTA/GTTGCT 1 -- ds50010--------
    rs2012043411,2
    		--128516555(+) ACACT-/CAGTAT 1 -- ds50010--------
    rs69522231,2
    		C,F,H,--128516733(+) CTCCTT/CCTACC 1 -- ds50019Minor allele frequency- C:0.12NS EA NA WA CSA 540
    rs1850497821,2
    		--128516794(+) CAGGCA/TTGCAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for KCP (128502505 - 128550773 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for KCP
         4 CNVs: 70039 52084 4559 52083

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for KCP

    Disorders / Diseases
    for KCP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCP for disorders           About GeneDecksing

    OMIM gene information: 609344    OMIM disorders: --

    4 diseases for KCP:    About MalaCards
    neuronitis    shigellosis    kidney disease    fibrosis

    1 disease from the University of Copenhagen DISEASES database for KCP:
    Kaposi's sarcoma

    Export disorders for KCP gene to outside databases

    Publications
    for KCP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCP gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KCP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. (PubMed id 15793581)1, 3 Lin J....Dressler G.R. (2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease. (PubMed id 18446379)9 Zeisberg M. and Kalluri R. (2008)

    External Searches for KCP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KCP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 375616 HGNC: 17585 AceView: LOC375616 Ensembl:ENSG00000135253 euGenes: HUgn375616
    ECgene: KCP H-InvDB: KCP

    Other Databases showing KCP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCP gene:
    Search GeneIP for patents involving KCP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for KCP gene

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    About This Section

     
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