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Aliases for KCP Gene

Aliases for KCP Gene

  • Kielin/Chordin-Like Protein 2 3 5
  • Cysteine Rich BMP Regulator 2 (Chordin-Like) 2 3
  • Cysteine-Rich Motor Neuron 2 Protein 3 4
  • Cysteine-Rich BMP Regulator 2 3 4
  • Kielin/Chordin-Like Protein 1 3 4
  • Kielin 2 3
  • CRIM-2 3 4
  • CRIM2 3 4
  • KCP-1 3 4
  • KCP1 3 4
  • NET67 3

External Ids for KCP Gene

Previous HGNC Symbols for KCP Gene

  • CRIM2

Previous GeneCards Identifiers for KCP Gene

  • GC07Mg27914
  • GC07M128503
  • GC07M122878

Summaries for KCP Gene

GeneCards Summary for KCP Gene

KCP (Kielin/Chordin-Like Protein) is a Protein Coding gene. An important paralog of this gene is BMPER.

UniProtKB/Swiss-Prot for KCP Gene

  • Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity).

Additional gene information for KCP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCP Gene

Genomics for KCP Gene

Regulatory Elements for KCP Gene

Enhancers for KCP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H128932 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -23.7 -23722 3.3 HDGF PKNOX1 SIN3A BATF ZNF143 ATF7 ETV6 RUNX3 CREM IKZF2 IRF5 ATP6V1F KCP ENSG00000242162 FLNC FLNC-AS1 TSPAN33 TNPO3 TPI1P2 LOC392787
GH07H128936 1.2 ENCODE dbSUPER 12.5 -28.9 -28867 5.5 HDGF PKNOX1 ARID4B SIN3A GLIS2 ZNF143 ZNF207 ATF7 KLF7 RUNX3 IRF5 KCP ENSG00000242162 FLNC ATP6V1F FLNC-AS1 TPI1P2 TNPO3 TSPAN33 ENSG00000271553
GH07H128937 1.1 ENCODE dbSUPER 12.5 -25.7 -25683 0.2 ELF3 ARID4B ZBTB40 THRB ZSCAN9 RARA YY1 CREM MIXL1 THAP11 KCP ENSG00000242162 FLNC FLNC-AS1 ATP6V1F TSPAN33 TPI1P2 TNPO3 IRF5 LOC392787
GH07H128902 1.1 Ensembl ENCODE 8 +7.6 7630 1 HDGF NFRKB KLF17 FOS ATF7 ZEB2 TFDP1 ZNF589 MTA1 SMARCA4 KCP LOC105375497
GH07H129089 0.7 Ensembl 11.6 -179.2 -179165 0.6 CEBPG BATF POLR2A EED ETV6 RUNX3 IKZF2 CREM SRF NR2F1 TNPO3 OPN1SW SMO CALU TPI1P2 ENSG00000242162 KCP TSPAN33 FLNC CCDC136
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCP on UCSC Golden Path with GeneCards custom track

Genomic Locations for KCP Gene

Genomic Locations for KCP Gene
48,269 bases
Minus strand

Genomic View for KCP Gene

Genes around KCP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCP Gene

Proteins for KCP Gene

  • Protein details for KCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kielin/chordin-like protein
    Protein Accession:
    Secondary Accessions:
    • Q8NBE0

    Protein attributes for KCP Gene

    1503 amino acids
    Molecular mass:
    159938 Da
    Quaternary structure:
    • Interacts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic serine/threonine protein kinase domains. Also able to interact with activin-A and TGFB1 (By similarity).

    Alternative splice isoforms for KCP Gene


neXtProt entry for KCP Gene

Post-translational modifications for KCP Gene

  • Glycosylation at posLast=278278
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KCP Gene

Domains & Families for KCP Gene

Gene Families for KCP Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for KCP Gene

Suggested Antigen Peptide Sequences for KCP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KCP: view

No data available for UniProtKB/Swiss-Prot for KCP Gene

Function for KCP Gene

Molecular function for KCP Gene

UniProtKB/Swiss-Prot Function:
Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity).

Phenotypes From GWAS Catalog for KCP Gene

genes like me logo Genes that share phenotypes with KCP: view

Animal Models for KCP Gene

MGI Knock Outs for KCP:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for KCP Gene

Localization for KCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCP Gene


Gene Ontology (GO) - Cellular Components for KCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with KCP: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for KCP Gene

Pathways & Interactions for KCP Gene

No Data Available

Interacting Proteins for KCP Gene

Selected Interacting proteins: Q6ZWJ8-KCP_HUMAN for KCP Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for KCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030513 positive regulation of BMP signaling pathway IEA --
genes like me logo Genes that share ontologies with KCP: view

No data available for Pathways by source and SIGNOR curated interactions for KCP Gene

Drugs & Compounds for KCP Gene

No Compound Related Data Available

Transcripts for KCP Gene

mRNA/cDNA for KCP Gene

(13) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCP Gene

Kielin/chordin-like protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCP Gene

No ASD Table

Relevant External Links for KCP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCP Gene

This gene is overexpressed in Kidney - Cortex (x18.7), Brain - Cerebellum (x5.5), and Brain - Cerebellar Hemisphere (x5.3).

Protein differential expression in normal tissues from HIPED for KCP Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCP Gene

Protein tissue co-expression partners for KCP Gene

NURSA nuclear receptor signaling pathways regulating expression of KCP Gene:


SOURCE GeneReport for Unigene cluster for KCP Gene:

genes like me logo Genes that share expression patterns with KCP: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCP Gene

Orthologs for KCP Gene

This gene was present in the common ancestor of mammals.

Orthologs for KCP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC463713 33
  • 99.02 (n)
(Canis familiaris)
Mammalia KCP 33
  • 87.25 (n)
(Bos Taurus)
Mammalia LOC515624 33
  • 86.3 (n)
(Mus musculus)
Mammalia Kcp 33 16
  • 81.37 (n)
(Rattus norvegicus)
Mammalia Kcp 33
  • 80.9 (n)
Species where no ortholog for KCP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KCP Gene

Gene Tree for KCP (if available)
Gene Tree for KCP (if available)

Paralogs for KCP Gene

Paralogs for KCP Gene

(1) SIMAP similar genes for KCP Gene using alignment to 1 proteins: Pseudogenes for KCP Gene

genes like me logo Genes that share paralogs with KCP: view

Variants for KCP Gene

Sequence variations from dbSNP and Humsavar for KCP Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000137428 -- 128,909,526(+) AGTTA(C/T)TTAAG intron-variant
rs1000192188 -- 128,873,449(+) GGGCC(C/T)AGTCA intron-variant
rs1000341189 -- 128,903,954(+) CTCTC(A/G)GGAGG intron-variant, upstream-variant-2KB
rs1000367261 -- 128,870,159(+) TGGGC(G/T)CTCCC downstream-variant-500B, utr-variant-3-prime
rs1000403868 -- 128,890,267(+) TAGGG(C/T)AGTAA intron-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KCP Gene

Variant ID Type Subtype PubMed ID
nsv949945 CNV deletion 24416366
nsv949944 CNV deletion 24416366
nsv831125 CNV loss 17160897
nsv608415 CNV loss 21841781
nsv608409 CNV loss 21841781
nsv5946 CNV deletion 18451855
nsv517923 CNV gain 19592680
nsv517371 CNV gain+loss 19592680
nsv470392 CNV gain 18288195
nsv464717 CNV loss 19166990
nsv464715 CNV loss 19166990
nsv464713 CNV loss 19166990
nsv1145158 CNV deletion 24896259
nsv1109913 CNV deletion 24896259
esv3614990 CNV loss 21293372
esv2735145 CNV deletion 23290073
esv2735137 CNV deletion 23290073
esv2670312 CNV deletion 23128226
esv22837 CNV gain 19812545
dgv3941e59 CNV duplication 20981092
dgv11612n54 CNV loss 21841781
dgv11611n54 CNV loss 21841781

Relevant External Links for KCP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for KCP Gene

Disorders for KCP Gene

Relevant External Links for KCP

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KCP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCP Gene

Publications for KCP Gene

  1. Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. (PMID: 15793581) Lin J … Dressler GR (Nature medicine 2005) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson CA … Rioux JD (Nature genetics 2011) 45 60
  4. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. (PMID: 19838193) Han JW … Zhang XJ (Nature genetics 2009) 45 60
  5. Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease. (PMID: 18446379) Zeisberg M … Kalluri R (Pediatric nephrology (Berlin, Germany) 2008) 22 60

Products for KCP Gene

Sources for KCP Gene

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