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Aliases for KCP Gene

Aliases for KCP Gene

  • Kielin/Chordin-Like Protein 2 3
  • Cysteine Rich BMP Regulator 2 (Chordin-Like) 2 3
  • Cysteine-Rich Motor Neuron 2 Protein 3 4
  • Cysteine-Rich BMP Regulator 2 3 4
  • Kielin/Chordin-Like Protein 1 3 4
  • Kielin 2 3
  • CRIM-2 3 4
  • CRIM2 3 4
  • KCP-1 3 4
  • KCP1 3 4
  • NET67 3

External Ids for KCP Gene

Previous Symbols for KCP Gene

  • CRIM2

Summaries for KCP Gene

GeneCards Summary for KCP Gene

KCP (Kielin/Chordin-Like Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KCP Gene

  • Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCP Gene

Genomics for KCP Gene

Genomic Location for KCP Gene

Start:
128,862,451 bp from pter
End:
128,910,719 bp from pter
Size:
48,269 bases
Orientation:
Minus strand

Genomic View for KCP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCP Gene

Regulatory Elements for KCP Gene

Proteins for KCP Gene

  • Protein details for KCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZWJ8-KCP_HUMAN
    Recommended name:
    Kielin/chordin-like protein
    Protein Accession:
    Q6ZWJ8
    Secondary Accessions:
    • Q8NBE0

    Protein attributes for KCP Gene

    Size:
    1503 amino acids
    Molecular mass:
    159938 Da
    Quaternary structure:
    • Interacts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic serine/threonine protein kinase domains. Also able to interact with activin-A and TGFB1 (By similarity).

    Alternative splice isoforms for KCP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCP Gene

Proteomics data for KCP Gene at MOPED

Post-translational modifications for KCP Gene

Other Protein References for KCP Gene

No data available for DME Specific Peptides for KCP Gene

Domains for KCP Gene

Protein Domains for KCP Gene

UniProtKB/Swiss-Prot:

KCP_HUMAN
Domain:
  • Contains 1 TIL (trypsin inhibitory-like) domain.:
    • Q6ZWJ8
  • Contains 17 VWFC domains.:
    • Q6ZWJ8
  • Contains 1 VWFD domain.:
    • Q6ZWJ8
genes like me logo Genes that share domains with KCP: view

No data available for Gene Families for KCP Gene

Function for KCP Gene

Molecular function for KCP Gene

UniProtKB/Swiss-Prot Function: Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity).

Gene Ontology (GO) - Molecular Function for KCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KCP: view
genes like me logo Genes that share phenotypes with KCP: view

Animal Models for KCP Gene

MGI Knock Outs for KCP:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for KCP Gene

Localization for KCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCP Gene COMPARTMENTS Subcellular localization image for KCP gene
Compartment Confidence
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space --
genes like me logo Genes that share ontologies with KCP: view

Pathways for KCP Gene

SuperPathways for KCP Gene

No Data Available

Interacting Proteins for KCP Gene

Selected Interacting proteins: Q6ZWJ8-KCP_HUMAN for KCP Gene via I2D

Symbol External ID(s) Details
BMP7

Gene Ontology (GO) - Biological Process for KCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation --
GO:0030513 positive regulation of BMP signaling pathway --
genes like me logo Genes that share ontologies with KCP: view

No data available for Pathways by source for KCP Gene

Transcripts for KCP Gene

mRNA/cDNA for KCP Gene

(16) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCP Gene

Kielin/chordin-like protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCP Gene

No ASD Table

Relevant External Links for KCP Gene

GeneLoc Exon Structure for
KCP
ECgene alternative splicing isoforms for
KCP

Expression for KCP Gene

mRNA expression in normal human tissues for KCP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCP Gene

This gene is overexpressed in Kidney - Cortex (18.7), Brain - Cerebellum (5.5), and Brain - Cerebellar Hemisphere (5.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KCP Gene

SOURCE GeneReport for Unigene cluster for KCP Gene Hs.371746

genes like me logo Genes that share expressions with KCP: view

Orthologs for KCP Gene

This gene was present in the common ancestor of mammals.

Orthologs for KCP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC463713 36
  • 99.02 (n)
  • 98.34 (a)
cow
(Bos Taurus)
Mammalia LOC515624 36
  • 86.3 (n)
  • 83.52 (a)
dog
(Canis familiaris)
Mammalia KCP 36
  • 87.25 (n)
  • 85.5 (a)
mouse
(Mus musculus)
Mammalia Kcp 36
  • 81.37 (n)
  • 79.53 (a)
Kcp 16
rat
(Rattus norvegicus)
Mammalia Kcp 36
  • 80.9 (n)
  • 79.17 (a)
Species with no ortholog for KCP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KCP Gene

ENSEMBL:
Gene Tree for KCP (if available)
TreeFam:
Gene Tree for KCP (if available)

Paralogs for KCP Gene

Selected SIMAP similar genes for KCP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCP: view

No data available for Paralogs for KCP Gene

Variants for KCP Gene

Sequence variations from dbSNP and Humsavar for KCP Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1495461 -- 128,911,686(-) TTATG(A/G)CAGGG upstream-variant-2KB
rs1532222 -- 128,876,891(-) GTCAC(A/C)AGCAG utr-variant-3-prime
rs1609544 -- 128,909,977(+) CCCGT(A/G)GGGCC intron-variant
rs1609545 -- 128,910,840(+) CCCCG(A/G)GCCCG upstream-variant-2KB
rs1874333 -- 128,877,439(-) GCACA(A/G)AGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCP Gene

Variant ID Type Subtype PubMed ID
esv2735137 CNV Deletion 23290073
esv2670312 CNV Deletion 23128226
nsv831125 CNV Loss 17160897
esv22837 CNV Gain 19812545
nsv889192 CNV Loss 21882294
nsv517923 CNV Gain 19592680
nsv464713 CNV Loss 19166990
dgv7490n71 CNV Loss 21882294
nsv464715 CNV Loss 19166990
nsv464717 CNV Loss 19166990
nsv470392 CNV Gain 18288195
nsv517371 CNV Gain+Loss 19592680
dgv7491n71 CNV Loss 21882294
nsv5946 CNV Loss 18451855
esv2735145 CNV Deletion 23290073

Relevant External Links for KCP Gene

HapMap Linkage Disequilibrium report
KCP

Disorders for KCP Gene

(1) University of Copenhagen DISEASES for KCP Gene

Relevant External Links for KCP

Genetic Association Database (GAD)
KCP
genes like me logo Genes that share disorders with KCP: view

No data available for UniProtKB/Swiss-Prot for KCP Gene

Publications for KCP Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. (PMID: 15793581) Lin J. … Dressler G.R. (Nat. Med. 2005) 2 3
  3. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. (PMID: 19838193) Han J.W. … Zhang X.J. (Nat. Genet. 2009) 49
  4. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson C.A. … Rioux J.D. (Nat. Genet. 2011) 49
  5. Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease. (PMID: 18446379) Zeisberg M. … Kalluri R. (Pediatr. Nephrol. 2008) 23

Products for KCP Gene

Sources for KCP Gene

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