Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KCNV1 Gene

protein-coding   GIFtS: 55
GCID: GC08M111048

Potassium Channel, Subfamily V, Member 1

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Potassium Channel, Subfamily V, Member 11 2     KCNB32
Neuronal Potassium Channel Alpha Subunit HNKA2 3     KV2.32
Voltage-Gated Potassium Channel Subunit Kv8.12 3     Potassium Channel Kv8.12
KV8.12 5     Potassium Voltage-Gated Channel Subfamily V Member 12
HNKA2     

External Ids:    HGNC: 188611   Entrez Gene: 270122   Ensembl: ENSG000001647947   OMIM: 6081645   UniProtKB: Q6PIU13   

Export aliases for KCNV1 gene to outside databases

Previous GC identifers: GC08M109963 GC08M111046 GC08M110648 GC08M110935 GC08M106302


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for KCNV1 Gene:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both
functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart
rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and
cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This protein is
essentially present in the brain, and its role might be to inhibit the function of a particular class of outward
rectifier potassium channel types. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNV1 Gene:
KCNV1 (potassium channel, subfamily V, member 1) is a protein-coding gene. GO annotations related to this gene include ion channel inhibitor activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNF1.

UniProtKB/Swiss-Prot: KCNV1_HUMAN, Q6PIU1
Function: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2
channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of
inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them
in intracellular membranes

summary for KCNV1 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNV1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNV1 gene promoter:
         POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   C/EBPalpha   RORalpha2   SRY   POU2F1   HFH-1   POU2F1a   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNV1 promoter sequence
   Search Chromatin IP Primers for KCNV1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNV1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23.2   Ensembl cytogenetic band:  8q23.2   HGNC cytogenetic band: 8q23.2

KCNV1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNV1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M111048:  view genomic region     (about GC identifiers)

Start:
110,975,874 bp from pter      End:
110,988,076 bp from pter
Size:
12,203 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KCNV1_HUMAN, Q6PIU1 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily V member 1  
Size: 500 amino acids; 56304 Da
Subunit: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1
Secondary accessions: Q9UHJ4

Explore the universe of human proteins at neXtProt for KCNV1: NX_Q6PIU1

Explore proteomics data for KCNV1 at MOPED


See KCNV1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_055194.1  
ENSEMBL proteins: 
 ENSP00000435954   ENSP00000297404  
Reactome Protein details: Q6PIU1

KCNV1 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for KCNV1
OriGene Custom MassSpec
OriGene Custom Protein Services for KCNV1
GenScript Custom Purified and Recombinant Proteins Services for KCNV1
Novus Biologicals KCNV1 Proteins
Novus Biologicals KCNV1 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for KCNV1

 
Search eBioscience for Proteins for KCNV1 

 
antibodies-online proteins for KCNV1 (4 products) 

 
antibodies-online peptides for KCNV1

KCNV1 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for KCNV1
Novus Biologicals KCNV1 Antibody
Abcam antibodies for KCNV1
Cloud-Clone Corp. Antibodies for KCNV1
ThermoFisher Antibody for KCNV1
LSBio Antibodies in human, mouse, rat for KCNV1
antibodies-online antibodies for KCNV1 (11 products) 

KCNV1 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for KCNV1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for KCNV1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for KCNV1
Cloud-Clone Corp. CLIAs for KCNV1
Search eBioscience for ELISAs for KCNV1 
antibodies-online kits for KCNV1 (8 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
KCN: Potassium channels
Kv: Voltage-gated ion channels / Potassium channels

IUPHAR Guide to PHARMACOLOGY protein family classification: Kv8.1
Voltage-gated potassium channels

Selected InterPro protein domains (see all 9):
 IPR005821 Ion_trans_dom
 IPR000210 BTB/POZ-like
 IPR011333 BTB/POZ_fold
 IPR027359 Channel_four-helix_dom
 IPR003970 K_chnl_volt-dep_Kv8

Graphical View of Domain Structure for InterPro Entry Q6PIU1

ProtoNet protein and cluster: Q6PIU1

3 Blocks protein domains:
IPB000210 BTB/POZ domain
IPB003091 Potassium channel signature
IPB003970 Kv8 potassium channel alpha subunit signature


UniProtKB/Swiss-Prot: KCNV1_HUMAN, Q6PIU1
Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
acids at every third position (By similarity)
Similarity: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily


Find genes that share domains with KCNV1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: KCNV1_HUMAN, Q6PIU1
Function: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2
channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of
inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them
in intracellular membranes

     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005216ion channel activity ----
GO:0005251delayed rectifier potassium channel activity IBA--
GO:0005267potassium channel activity ----
GO:0005515protein binding ----
GO:0008200ion channel inhibitor activity TAS8670833
     
Find genes that share ontologies with KCNV1           About GenesLikeMe


Phenotypes:
     3 GenomeRNAi human phenotypes for KCNV1:
 Increased circadian rhythm amp  Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

     2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kcnv1):
 behavior/neurological  muscle 

Find genes that share phenotypes with KCNV1           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Kcnv1tm1Lex for KCNV1

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNV1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KCNV1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCNV1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCNV1

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat KCNV1 using miScript Target Protectors
4 qRT-PCR Assays for microRNAs that regulate KCNV1:
hsa-miR-374a* hsa-miR-2116 hsa-miR-944 hsa-miR-545
SwitchGear 3'UTR luciferase reporter plasmidKCNV1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for KCNV1
Predesigned siRNA for gene silencing in human, mouse, rat KCNV1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for KCNV1

Clone
Products:
     
OriGene clones in human, mouse for KCNV1 (see all 6)
OriGene ORF clones in mouse, rat for KCNV1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: KCNV1 (NM_014379)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNV1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNV1

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for KCNV1
Browse ESI BIO Cell Lines and PureStem Progenitors for KCNV1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNV1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
KCNV1_HUMAN, Q6PIU1: Cell membrane; Multi-pass membrane protein. Note=Has to be associated with another potassium
channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0005887integral component of plasma membrane TAS8670833
GO:0008076voltage-gated potassium channel complex IEA--
GO:0016020membrane ----

Find genes that share ontologies with KCNV1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for KCNV1 About   (see all 6)  
See pathways by source

SuperPathContained pathways About
1Sweet Taste Signaling
Sweet Taste Signaling0.72
Bitter Taste Signaling0.44
Melatonin Signaling0.72
Sperm Motility0.37
Cellular Effects of Sildenafil0.46
2Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA0.77
PKA Signaling0.56
cAMP Pathway0.77
3Neuropathic Pain-Signaling in Dorsal Horn Neurons
Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
Cholera Infection0.40
Aldosterone Signaling in Epithelial Cells0.47
4Potassium Channels
Potassium Channels0.43
Voltage gated Potassium channels0.43
5Hepatic ABC Transporters
Hepatic ABC Transporters0.41
MODY (Maturity-Onset Diabetes of Young)0.41


Find genes that share SuperPaths with KCNV1           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KCNV1 (see all 13)
    Cholera Infection
Neuropathic Pain-Signaling in Dorsal Horn Neurons
Hepatic ABC Transporters
PKA Signaling
Sweet Taste Signaling

1 Reactome Pathway for KCNV1
    Voltage gated Potassium channels


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNV1
Interactions:

    GeneGlobe Interaction Network for KCNV1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for KCNV1 (Q6PIU13 ENSP000002974044) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
InteractantInteraction Details
GeneCardExternal ID(s)
KCNB1Q147213, ENSP000003608064I2D: score=1 STRING: ENSP00000360806
KCNB2Q929533I2D: score=1 
KCNA10ENSP000003587864STRING: ENSP00000358786
KCNA2ENSP000003145204STRING: ENSP00000314520
KCNA3ENSP000003587844STRING: ENSP00000358784
About this table

Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006811ion transport ----
GO:0006813potassium ion transport TAS8670833
GO:0007268synaptic transmission TAS--
GO:0051260protein homooligomerization IEA--
GO:0055085transmembrane transport ----

Find genes that share ontologies with KCNV1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for KCNV1 available from Tocris Bioscience    About this table
CompoundAction CAS #
ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
JNJ 303Potent and selective IKs blocker[878489-28-2]
E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for KCNV1 gene: 
NM_014379.2  

Unigene Cluster for KCNV1:

Potassium channel, subfamily V, member 1
Hs.13285  [show with all ESTs]
Unigene Representative Sequence: AK308123
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000524391(uc003ynr.4 uc010mcw.3) ENST00000297404
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat KCNV1 using miScript Target Protectors
4 qRT-PCR Assays for microRNAs that regulate KCNV1:
hsa-miR-374a* hsa-miR-2116 hsa-miR-944 hsa-miR-545
SwitchGear 3'UTR luciferase reporter plasmidKCNV1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for KCNV1
Predesigned siRNA for gene silencing in human, mouse, rat KCNV1
Clone
Products:
     
OriGene clones in human, mouse for KCNV1 (see all 6)
OriGene ORF clones in mouse, rat for KCNV1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: KCNV1 (NM_014379)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNV1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNV1
Primer
Products:
    
OriGene qPCR primer pairs and template standards for KCNV1
OriGene qSTAR qPCR primer pairs in human, mouse for KCNV1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNV1
  QuantiTect SYBR Green Assays in human, mouse, rat KCNV1
  QuantiFast Probe-based Assays in human, mouse, rat KCNV1

Additional mRNA sequence: 

AF167082.2 AK297393.1 AK308123.1 AK313469.1 BC028739.2 

2 DOTS entries:

DT.309438  DT.120635958 

15 AceView cDNA sequences:

AW157426 AW163488 NM_014379 BC028739 F10179 F12562 U69191 T06525 
AL119500 AF167082 T89084 H11972 BI546881 T74525 AL119499 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

KCNV1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTGAATTGT
KCNV1 Expression
About this image

KCNV1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

KCNV1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.13285

UniProtKB/Swiss-Prot: KCNV1_HUMAN, Q6PIU1
Tissue specificity: Detected in brain

    Custom PCR Arrays for KCNV1
Primer
Products:
OriGene qPCR primer pairs and template standards for KCNV1
OriGene qSTAR qPCR primer pairs in human, mouse for KCNV1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNV1
QuantiTect SYBR Green Assays in human, mouse, rat KCNV1
QuantiFast Probe-based Assays in human, mouse, rat KCNV1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNV1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for KCNV1 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Kcnv11 , 5 potassium channel, subfamily V, member 11, 5 88.98(n)1
96.77(a)1
  15 (17.25 cM)5
674981  NM_026200.31  NP_080476.21 
 451062845 
chicken
(Gallus gallus)
Aves KCNV11 potassium channel, subfamily V, member 1 74.83(n)
79.15(a)
  420278  XM_004940003.1  XP_004940060.1 
lizard
(Anolis carolinensis)
Reptilia KCNV16
potassium channel, subfamily V, member 1
74(a)
1 ↔ 1
4(10586090-10598305)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004870061 potassium voltage-gated channel subfamily V member more 67.59(n)
71.95(a)
  100487006  XM_002938982.2  XP_002939028.1 
zebrafish
(Danio rerio)
Actinopterygii LOC5599151 potassium voltage-gated channel subfamily V member more 66.6(n)
68.95(a)
  559915  XM_683312.2  XP_688404.1 


ENSEMBL Gene Tree for KCNV1 (if available)
TreeFam Gene Tree for KCNV1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for KCNV1 gene
KCNF12  KCNG32  KCNB22  KCNG22  KCNS22  KCNS32  KCNB12  KCNV22  
KCNG42  KCNG12  KCNS12  
Selected SIMAP similar genes for KCNV1 using alignment to 2 protein entries:     KCNV1_HUMAN (see all proteins) (see all similar genes):
KCNB1    KCNB2    KCNV2    KCNS2    KCNS3    KCNF1
KCNG1    KCNG4    KCND3    KCND1    KCNG2    KCNG3
KCNS1    KCND2    KCNA1    KCNC2    KCNA10    KCNA2

Find genes that share paralogs with KCNV1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for KCNV1 (see all 173)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1840301091,2
--110979156(+) AGGTAC/TTAAAG 1 -- ds50010--------
rs1489377751,2
--110979483(+) ATGTTC/TACTAC 1 -- ut310--------
rs1878214371,2
--110979604(+) ATGCTC/TCACAT 1 -- ut310--------
rs1427730241,2
--110979707(+) CTCTTA/GTAGTA 1 -- ut310--------
rs1146991501,2
C--110979811(+) CTCTTC/GTAAAG 1 -- ut310--------
rs1925042251,2
--110979831(+) ATATTC/TAATAG 1 -- ut310--------
rs1403765241,2
--110979836(+) CAATAA/GCTTTA 1 -- ut310--------
rs174683751,2
C,F--110979845(+) TAACTG/AATAGA 1 -- ut314Minor allele frequency- A:0.03NA 262
rs174684101,2
C,F,H--110979871(+) TGTACT/CTGGAT 1 -- ut3111Minor allele frequency- C:0.03NA NS 1040
rs1838350461,2
--110979969(+) AAAAAA/TTAGTG 1 -- ut310--------

HapMap Linkage Disequilibrium report for KCNV1 (110975874 - 110988076 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for KCNV1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv6347CNV Loss18451855
nsv831421CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing KCNV1
DNA2.0 Custom Variant and Variant Library Synthesis for KCNV1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 608164    OMIM disorders: --

1 disease from the University of Copenhagen DISEASES database for KCNV1:
Epilepsy syndrome

Find genes that share disorders with KCNV1           About GenesLikeMe

Genetic Association Database (GAD): KCNV1

Export disorders for KCNV1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for KCNV1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with KCNV1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels. (PubMed id 8670833)1, 2, 3 Hugnot J.-P.... Lazdunski M. (EMBO J. 1996)
  2. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (Pharmacol. Rev. 2005)
  3. Positional candidate approach for the gene responsible for benign adult familial myoclonic epilepsy. (PubMed id 12383276)1, 2 Sano A.... Kaneko S. (Epilepsia 2002)
  4. Modes of regulation of shab K+ channel activity by the Kv8.1 subunit. (PubMed id 9079713)1, 2 Salinas M.... Hugnot J.-P. (J. Biol. Chem. 1997)
  5. Structural characterization and promoter analysis of human potassium channel Kv8.1 (KCNV1) gene. (PubMed id 14697513)1, 9 Ebihara M.... Yoshikawa T. (Gene 2004)
  6. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (BMC Med. Genet. 2007)
  7. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 27012 HGNC: 18861 AceView: KCNV1 Ensembl:ENSG00000164794 euGenes: HUgn27012
ECgene: KCNV1 H-InvDB: KCNV1

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for KCNV1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for KCNV1 gene:
Search GeneIP for patents involving KCNV1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KCNV1  
 OriGene qPCR primer pairs and template standards for KCNV1   OriGene Protein Over-expression Lysate for KCNV1  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for KCNV1  
 OriGene qSTAR qPCR primer pairs in human, mouse for KCNV1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for KCNV1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for KCNV1   OriGene Custom Protein Services for KCNV1  

 
 
 Block miRNA regulation of human, mouse, rat KCNV1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KCNV1
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNV1 Predesigned siRNA for gene silencing in human, mouse, rat KCNV1
 QuantiFast Probe-based Assays in human, mouse, rat KCNV1 QuantiTect SYBR Green Assays in human, mouse, rat KCNV1
 Custom PCR Arrays for KCNV1 Search Chromatin IP Primers for KCNV1
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNV1  GeneGlobe Interaction Network for KCNV1
 Regulatory tfbs in KCNV1 promoter
 GenScript Custom Purified and Recombinant Proteins Services for KCNV1 GenScript cDNA clones with any tag delivered in your preferred vector for KCNV1
 GenScript Custom Assay Services for KCNV1 GenScript Custom overexpressing Cell Line Services for KCNV1
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Tocris compounds for KCNV1
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 KCNV1 antibodies
 KCNV1 proteins
 KCNV1 lysates
 Antibodies for KCNV1
 See all of Abcam's Antibodies, Kits and Proteins for KCNV1
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for KCNV1
 Antibodies for KCNV1
 ELISAs for KCNV1
 CLIAs for KCNV1



 Browse ESI BIO Cell Lines and PureStem Progenitors for KCNV1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNV1
 SwitchGear 3'UTR luciferase reporter plasmids for KCNV1
 SwitchGear Promoter luciferase reporter plasmids for KCNV1
 ThermoFisher Antibody for KCNV1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNV1
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNV1
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KCNV1
 LSBio Antibodies in human, mouse, rat for KCNV1
 Browse compounds at ApexBio
 Search Addgene for plasmids for KCNV1
  Search eBioscience for proteins for KCNV1
  Search eBioscience for elisas for KCNV1
  eBioscience FlowRNA Probe Sets
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 antibodies-online antibodies for KCNV1 (11 products)
 antibodies-online kits for KCNV1 (8 products)
 antibodies-online peptides for KCNV1
 antibodies-online proteins for KCNV1 (4 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      KCNV1 gene at Home site.
Version: 3.12.234 23 Oct 2014
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4