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Aliases for KCNV1 Gene

Aliases for KCNV1 Gene

  • Potassium Channel, Voltage Gated Modifier Subfamily V, Member 1 2 3
  • Neuronal Potassium Channel Alpha Subunit HNKA 3 4
  • Voltage-Gated Potassium Channel Subunit Kv8.1 3 4
  • Potassium Channel, Subfamily V, Member 1 2 3
  • KV8.1 3 6
  • Potassium Voltage-Gated Channel Subfamily V Member 1 3
  • Potassium Channel Kv8.1 3
  • KCNB3 3
  • KV2.3 3
  • HNKA 3

External Ids for KCNV1 Gene

Previous GeneCards Identifiers for KCNV1 Gene

  • GC08M111046
  • GC08M110648
  • GC08M110935
  • GC08M111048
  • GC08M106302

Summaries for KCNV1 Gene

Entrez Gene Summary for KCNV1 Gene

  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This protein is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNV1 Gene

KCNV1 (Potassium Channel, Voltage Gated Modifier Subfamily V, Member 1) is a Protein Coding gene. Diseases associated with KCNV1 include benign adult familial myoclonic epilepsy. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include delayed rectifier potassium channel activity and ion channel inhibitor activity. An important paralog of this gene is KCNB2.

UniProtKB/Swiss-Prot for KCNV1 Gene

  • Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

Tocris Summary for KCNV1 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNV1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNV1 Gene

Genomics for KCNV1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCNV1 Gene

Start:
109,963,645 bp from pter
End:
109,975,847 bp from pter
Size:
12,203 bases
Orientation:
Minus strand

Genomic View for KCNV1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNV1 Gene

Proteins for KCNV1 Gene

  • Protein details for KCNV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PIU1-KCNV1_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily V member 1
    Protein Accession:
    Q6PIU1
    Secondary Accessions:
    • Q9UHJ4

    Protein attributes for KCNV1 Gene

    Size:
    500 amino acids
    Molecular mass:
    56304 Da
    Quaternary structure:
    • Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.

neXtProt entry for KCNV1 Gene

Proteomics data for KCNV1 Gene at MOPED

Post-translational modifications for KCNV1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNV1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KCNV1 Gene

Domains for KCNV1 Gene

Gene Families for KCNV1 Gene

HGNC:
  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q6PIU1

UniProtKB/Swiss-Prot:

KCNV1_HUMAN :
  • Q6PIU1
Domain:
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Family:
  • Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
genes like me logo Genes that share domains with KCNV1: view

Function for KCNV1 Gene

Molecular function for KCNV1 Gene

UniProtKB/Swiss-Prot Function:
Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

Gene Ontology (GO) - Molecular Function for KCNV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005251 delayed rectifier potassium channel activity IBA --
GO:0005267 potassium channel activity --
GO:0005515 protein binding --
GO:0008200 ion channel inhibitor activity TAS 8670833
genes like me logo Genes that share ontologies with KCNV1: view
genes like me logo Genes that share phenotypes with KCNV1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNV1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNV1 Gene

Localization for KCNV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNV1 Gene

Cell membrane; Multi-pass membrane protein. Note=Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNV1 Gene COMPARTMENTS Subcellular localization image for KCNV1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for KCNV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8670833
GO:0008076 voltage-gated potassium channel complex IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with KCNV1: view

Pathways for KCNV1 Gene

genes like me logo Genes that share pathways with KCNV1: view

Gene Ontology (GO) - Biological Process for KCNV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006813 potassium ion transport TAS 8670833
GO:0007268 synaptic transmission TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCNV1: view

Compounds for KCNV1 Gene

(5) Tocris Compounds for KCNV1 Gene

Compound Action Cas Number
4-Aminopyridine Non-selective KV channel blocker [504-24-5]
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
Margatoxin Potent KV1.3 channel blocker [145808-47-5]
MaxiPost Potassium channel modulator; exerts subtype-specific effects [187523-35-9]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents [122955-13-9]
genes like me logo Genes that share compounds with KCNV1: view

Transcripts for KCNV1 Gene

mRNA/cDNA for KCNV1 Gene

(15) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNV1 Gene

Potassium channel, subfamily V, member 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNV1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNV1 Gene

No ASD Table

Relevant External Links for KCNV1 Gene

GeneLoc Exon Structure for
KCNV1
ECgene alternative splicing isoforms for
KCNV1

Expression for KCNV1 Gene

mRNA expression in normal human tissues for KCNV1 Gene

mRNA differential expression in normal tissues according to GTEx for KCNV1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (14.5), Brain - Cortex (10.5), Brain - Anterior cingulate cortex (BA24) (10.1), and Brain - Amygdala (5.0).

SOURCE GeneReport for Unigene cluster for KCNV1 Gene Hs.13285

mRNA Expression by UniProt/SwissProt for KCNV1 Gene

Q6PIU1-KCNV1_HUMAN
Tissue specificity: Detected in brain.
genes like me logo Genes that share expressions with KCNV1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for KCNV1 Gene

Orthologs for KCNV1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNV1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNV1 35
  • 91.13 (n)
  • 96.8 (a)
KCNV1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC482009 35
  • 93.07 (n)
  • 98 (a)
KCNV1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnv1 35
  • 88.98 (n)
  • 96.77 (a)
Kcnv1 16
Kcnv1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNV1 35
  • 99.73 (n)
  • 99.8 (a)
KCNV1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnv1 35
  • 88.58 (n)
  • 96.37 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNV1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNV1 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNV1 35
  • 74.83 (n)
  • 79.15 (a)
KCNV1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNV1 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487006 35
  • 67.59 (n)
  • 71.95 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC559915 35
  • 66.6 (n)
  • 68.95 (a)
KCNV1 36
  • 64 (a)
OneToOne
Species with no ortholog for KCNV1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNV1 Gene

ENSEMBL:
Gene Tree for KCNV1 (if available)
TreeFam:
Gene Tree for KCNV1 (if available)

Paralogs for KCNV1 Gene

Paralogs for KCNV1 Gene

Selected SIMAP similar genes for KCNV1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCNV1: view

Variants for KCNV1 Gene

Sequence variations from dbSNP and Humsavar for KCNV1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs735913 -- 109,971,585(+) GCTCT(A/G)TGATA intron-variant
rs746596 -- 109,972,243(-) TTTCA(C/T)TGATG intron-variant
rs755136 -- 109,971,843(+) CACTT(C/G)TCGGA intron-variant
rs1032890 -- 109,971,536(-) CATAT(A/G)ACACA intron-variant
rs3735903 -- 109,968,175(+) CGGGC(A/G)TAGAC synonymous-codon, reference, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KCNV1 Gene

Variant ID Type Subtype PubMed ID
nsv831421 CNV Gain 17160897
nsv6347 CNV Loss 18451855

Relevant External Links for KCNV1 Gene

HapMap Linkage Disequilibrium report
KCNV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNV1 Gene

Disorders for KCNV1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for KCNV1 Gene in MalaCards »

(1) Diseases for KCNV1 Gene including...

(1) University of Copenhagen DISEASES for KCNV1 Gene

Relevant External Links for KCNV1

Genetic Association Database (GAD)
KCNV1
genes like me logo Genes that share disorders with KCNV1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for KCNV1 Gene

Publications for KCNV1 Gene

  1. Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels. (PMID: 8670833) Hugnot J.-P. … Lazdunski M. (EMBO J. 1996) 2 3 4
  2. Modes of regulation of shab K+ channel activity by the Kv8.1 subunit. (PMID: 9079713) Salinas M. … Hugnot J.-P. (J. Biol. Chem. 1997) 3 4
  3. Structural characterization and promoter analysis of human potassium channel Kv8.1 (KCNV1) gene. (PMID: 14697513) Ebihara M. … Yoshikawa T. (Gene 2004) 3 23
  4. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3
  5. Positional candidate approach for the gene responsible for benign adult familial myoclonic epilepsy. (PMID: 12383276) Sano A. … Kaneko S. (Epilepsia 2002) 3 4

Products for KCNV1 Gene

Sources for KCNV1 Gene

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