Aliases for KCNV1 Gene
- Potassium Voltage-Gated Channel Modifier Subfamily V Member 1 2 3
- Potassium Channel, Voltage Gated Modifier Subfamily V, Member 1 2 3 5
- Neuronal Potassium Channel Alpha Subunit HNKA 3 4
- Voltage-Gated Potassium Channel Subunit Kv8.1 3 4
- Potassium Channel, Subfamily V, Member 1 2 3
- Potassium Channel Kv8.1 3
External Ids for KCNV1 Gene
Previous GeneCards Identifiers for KCNV1 Gene
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This protein is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNV1 Gene
KCNV1 (Potassium Voltage-Gated Channel Modifier Subfamily V Member 1) is a Protein Coding gene. Diseases associated with KCNV1 include benign adult familial myoclonic epilepsy and early myoclonic encephalopathy. Among its related pathways are Transmission across Chemical Synapses and Hepatic ABC Transporters. GO annotations related to this gene include ion channel activity and potassium channel regulator activity. An important paralog of this gene is KCNB1.
UniProtKB/Swiss-Prot for KCNV1 Gene
Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.