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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNU1 Gene

protein-coding   GIFtS: 50
GCID: GC08P036641

Potassium Channel, Subfamily U, Member 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Channel, Subfamily U, Member 11 2     KCa5.12
KCNMC12 3     Kcnma32
KCa52 3     Slo32
Calcium-Activated Potassium Channel Subunit Alpha-32 3     Potassium Channel Subfamily U Member 12
Calcium-Activated Potassium Channel, Subfamily M Subunit Alpha-32 3     KCNMA33
Slowpoke Homolog 32 3     SLO33

External Ids:    HGNC: 188671   Entrez Gene: 1578552   Ensembl: ENSG000002152627   OMIM: 6152155   UniProtKB: A8MYU23   

Export aliases for KCNU1 gene to outside databases

Previous GC identifers: GC08U990155 GC08P036761 GC08P035176


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KCNU1 Gene: 
KCNU1 (potassium channel, subfamily U, member 1) is a protein-coding gene. Diseases associated with KCNU1 include maturity-onset diabetes of the young, and male infertility, and among its related super-pathways are Melatonin Signaling and Activation of cAMP-Dependent PKA. GO annotations related to this gene include large conductance calcium-activated potassium channel activity and nucleotide binding. An important paralog of this gene is KCNMA1.

UniProtKB/Swiss-Prot: KCNU1_HUMAN, A8MYU2
Function: Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates
export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not
activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation
required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those
experienced after mixing with seminal fluid and entry into the vagina

summary for KCNU1 Gene:
Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+
ions across biological membranes. They are broadly classified into three subtypes, SK, IK and BK channels,
based on their conductance (small, intermediate and big conductance respectively). The small conductance KCa
channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance
KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both
play important roles in many processes involving Ca2+-dependent signalling in both electrically excitable
and non-excitable cells. The BK family of KCa channels (also known as Slo or Maxi-K channels) are also
voltage-sensitive and include KCa1.1 (Slo1), KCa4.1 (Slo2.2), KCa4.2 (Slo2.1) and KCa5.1 (Slo3). These
channels do not require calmodulin for activation as they contain three direct bivalent cation binding
sites.

Gene Wiki entry for KCNU1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNU1 gene promoter:
         RFX1   ISGF-3   Nkx2-5   POU3F2   Gfi-1   Evi-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KCNU1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNU1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.23   Ensembl cytogenetic band:  8p11.23   HGNC cytogenetic band: 8p11.2

KCNU1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNU1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P036641:  view genomic region     (about GC identifiers)

Start:
36,641,842 bp from pter      End:
36,793,646 bp from pter
Size:
151,805 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCNU1_HUMAN, A8MYU2 (See protein sequence)
Recommended Name: Potassium channel subfamily U member 1  
Size: 1149 amino acids; 129543 Da
Subunit: Homotetramer; which constitutes the calcium-activated potassium channel (By similarity). May interact
with LRRC52; this interaction may change channel gating properties, such as shifting gating to more negative
potentials at a given pH (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
1 PDB 3D structure from and Proteopedia for KCNU1:
4HPF (3D)    

Explore the universe of human proteins at neXtProt for KCNU1: NX_A8MYU2

Explore proteomics data for KCNU1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A8MYU2

  • KCNU1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCNU1 Protein Expression
    REFSEQ proteins: NP_001027006.2  
    ENSEMBL proteins: 
     ENSP00000429951   ENSP00000382770   ENSP00000428552   ENSP00000429149   ENSP00000428106  
    Reactome Protein details: A8MYU2
    Human Recombinant Protein Products for KCNU1: 
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    Cloud-Clone Corp. Proteins for KCNU1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IBA--
    GO:0016020membrane ----
    GO:0016021integral to membrane ----

    KCNU1 for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for KCNU1 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KCN: Potassium channels
    KCa: Voltage-gated ion channels / Potassium channels, calcium-activated

    IUPHAR Guide to PHARMACOLOGY protein family classification: KCa5.1 
    Calcium-activated potassium channels

    3 InterPro protein domains:
     IPR005821 Ion_trans_dom
     IPR016040 NAD(P)-bd_dom
     IPR003929 K_chnl_Ca-activ_BK_asu

    Graphical View of Domain Structure for InterPro Entry A8MYU2

    ProtoNet protein and cluster: A8MYU2

    UniProtKB/Swiss-Prot: KCNU1_HUMAN, A8MYU2
    Domain: The S4 segment, which is characterized by a series of positively charged amino acids at every third
    position, is part of the voltage-sensor (By similarity)
    Domain: The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the
    selectivity filter of the pore. It contains the signature sequence of potassium channels that displays
    selectivity to potassium (By similarity)
    Domain: The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers
    into functional potassium channel (By similarity)
    Domain: The C-terminal cytosolic region confers the pH-dependence (By similarity)
    Similarity: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa5.1/KCNU1
    sub-subfamily
    Similarity: Contains 1 RCK N-terminal domain


    KCNU1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNU1_HUMAN, A8MYU2
    Function: Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates
    export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not
    activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation
    required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those
    experienced after mixing with seminal fluid and entry into the vagina

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005249voltage-gated potassium channel activity IBA--
    GO:0005267potassium channel activity TAS--
    GO:0015269calcium-activated potassium channel activity ----
    GO:0060072large conductance calcium-activated potassium channel activity IBA--
         
    KCNU1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KCNU1:
     Decreased Salmonella enterica  

         1 MGI mutant phenotype (inferred from 3 alleles(MGI details for Kcnu1):
     reproductive system 

    KCNU1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KCNU1: Kcnu1tm1Cmsa Kcnu1tm1.2Clin

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KCNU1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KCNU1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCNU1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCNU1 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate KCNU1:
    hsa-miR-2115
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNU1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KCNU1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37
    Cellular Effects of Sildenafil0.46
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    4Fertilization
    Fertilization0.38
    Sperm Motility And Taxes0.35
    Reproduction0.38
    5Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    MODY (Maturity-Onset Diabetes of Young)0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCNU1 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling

    3        Reactome Pathways for KCNU1
        Fertilization
    Sperm Motility And Taxes
    Reproduction


    2         Kegg Pathways  (Kegg details for KCNU1):
        Vascular smooth muscle contraction
    Insulin secretion


    KCNU1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNU1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for KCNU1 (ENSP000003827704) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKACAENSP000003095914STRING: ENSP00000309591
    PRKACBENSP000003597194STRING: ENSP00000359719
    PRKACGENSP000003664884STRING: ENSP00000366488
    PRKG1ENSP000003630924STRING: ENSP00000363092
    PRKXENSP000002628484STRING: ENSP00000262848
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport ----
    GO:0007338single fertilization TAS--
    GO:0032504multicellular organism reproduction TAS--
    GO:0035036sperm-egg recognition TAS--
    GO:0071805potassium ion transmembrane transport IBA--

    KCNU1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNU1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PaxillineSERCA ATPase blocker. Also potent BKCa channel blocker[57186-25-1]
    TRAM 34Highly selective KCa3.1 channel blocker[289905-88-0]
    CyPPAActivator of KCa2.2 and KCa2.3 channels[73029-73-9]
    ApaminKCa2 channel blocker (small conductance)[24345-16-2]
    IberiotoxinKCa channel blocker (big conductance)[129203-60-7]

    1 HMDB Compound for KCNU1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    5 IUPHAR Ligands for KCNU1 (KCa5.1)    About this table 
    LigandTypeActionAffinityPubmed IDs
    iberiotoxin
    InhibitorNone--
    tetraethylammonium
    InhibitorNone--
    NS1619
    ActivatorNone--
    charybdotoxin
    InhibitorNone--
    NS004
    ActivatorNone--

    Search CenterWatch for drugs/clinical trials and news about KCNU1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KCNU1 gene: 
    NM_001031836.2  

    Unigene Cluster for KCNU1:

    Potassium channel, subfamily U, member 1
    Hs.13861  [show with all ESTs]
    Unigene Representative Sequence: BC028701
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523973 ENST00000399881(uc010lvw.3) ENST00000522372(uc003xjw.2)
    ENST00000522417 ENST00000518904
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate KCNU1:
    hsa-miR-2115
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK302391.1 BC028701.2 

    3 DOTS entries:

    DT.91917608  DT.120648295  DT.209915 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNU1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCATTTTTCT
    KCNU1 Expression
    About this image


    See KCNU1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNU1

    SOURCE GeneReport for Unigene cluster: Hs.13861

    UniProtKB/Swiss-Prot: KCNU1_HUMAN, A8MYU2
    Tissue specificity: Testis-specific

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNU1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KCNU1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnu11 , 5 potassium channel, subfamily U, member 11, 5 74.83(n)1
    69.09(a)1
      8 (14.17 cM)5
    165321  NM_008432.31  NP_032458.31 
     258496235 
    chicken
    (Gallus gallus)
    Aves KCNU16
    potassium channel, subfamily U, member 1
    44(a)
    1 ↔ 1
    22(1989333-2026713)
    lizard
    (Anolis carolinensis)
    Reptilia KCNU16
    Uncharacterized protein
    45(a)
    1 ↔ 1
    GL343624.1(275649-363051)
    zebrafish
    (Danio rerio)
    Actinopterygii kcnma1b6
    CABZ01093445.16
    Uncharacterized protein
    55(a)
    33(a)
    1 ↔ 1
    possible ortholog
    12(50379333-50390278)
    12(50425945-50437525)
    fruit fly
    (Drosophila melanogaster)
    Insecta slo6
    slowpoke
    34(a)
    1 → many
    3R(20488217-20536911)
    worm
    (Caenorhabditis elegans)
    Secernentea slo-16
    Calcium-activated potassium channel slo-1
    35(a)
    1 → many
    V(18492265-18508197)


    ENSEMBL Gene Tree for KCNU1 (if available)
    TreeFam Gene Tree for KCNU1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNU1 gene
    KCNMA12  KCNT12  KCNT22  
    1 SIMAP similar gene for KCNU1 using alignment to 5 protein entries:     KCNU1_HUMAN (see all proteins):
    KCNMA1

    KCNU1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3085 SNPs in KCNU1 are shown (see all 3085)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862330101,2
    --36639860(+) CCTCCA/GTTCAT 1 -- us2k10--------
    rs616216571,2
    C,F--36640039(+) TTTTAT/CGCTTT 1 -- us2k13Minor allele frequency- C:0.04WA CSA 121
    rs1498428701,2
    --36640130(+) GACTAC/TGAACA 1 -- us2k10--------
    rs21862961,2
    C,F,A,H--36640233(-) AAGGGC/TGATGT 1 -- us2k114Minor allele frequency- N:0.00NS EA NA WA 1292
    rs1448526271,2
    --36640409(+) TCCTCC/TTGGGC 1 -- us2k10--------
    rs1402237931,2
    --36640719(+) ATTGTA/CTTCTT 1 -- us2k10--------
    rs69818861,2
    C,F,H--36640740(+) ACTCTA/GTACTA 1 -- us2k17Minor allele frequency- G:0.05NS EA NA WA 540
    rs1148294351,2
    F--36640753(+) CCTTTC/GTTATG 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs765200661,2
    C--36640858(+) GATGCA/CCAGCA 1 -- us2k10--------
    rs1476788501,2
    --36640860(+) TGCACA/TGCAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNU1 (36641842 - 36793646 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KCNU1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2736881CNV Deletion23290073
    esv992767CNV Insertion20482838
    nsv831288CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615215    OMIM disorders: --

    7 diseases for KCNU1:    About MalaCards
    maturity-onset diabetes of the young    male infertility    infertility    cholera
    hepatitis    breast cancer    neuronitis


    KCNU1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KCNU1
    Human Genome Epidemiology (HuGE) Navigator: KCNU1 (1 document)

    Export disorders for KCNU1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNU1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KCNU1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional and structural analysis of the human SLO3 p H- and voltage-gated K+ channel. (PubMed id 23129643)1, 2 Leonetti M.D....Mackinnon R. (2012)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (2006)
    4. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (PubMed id 16382103)1, 3 Wei A.D....Wulff H. (2005)
    5. Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes. (PubMed id 9452476)1, 2 Schreiber M.... Salkoff L. (1998)
    6. Genetic variants associated with breast size also infl uence breast cancer risk. (PubMed id 22747683)1 Eriksson N....Tung J.Y. (2012)
    7. Genome-wide detection of allele specific copy number v ariation associated with insulin resistance in African Americans from the HyperG EN study. (PubMed id 21901158)1 Irvin M.R....Arnett D.K. (2011)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 157855 HGNC: 18867 Ensembl:ENSG00000215262 euGenes: HUgn157855 ECgene: KCNU1 Kegg: 157855
    H-InvDB: KCNU1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNU1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCNU1 gene:
    Search GeneIP for patents involving KCNU1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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