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Aliases for KCNU1 Gene

Aliases for KCNU1 Gene

  • Potassium Calcium-Activated Channel Subfamily U Member 1 2 3 5
  • Calcium-Activated Potassium Channel, Subfamily M Subunit Alpha-3 3 4
  • Calcium-Activated Potassium Channel Subunit Alpha-3 3 4
  • Potassium Channel, Subfamily U, Member 1 2 3
  • Slowpoke Homolog 3 3 4
  • Kcnma3 3 4
  • KCNMC1 3 4
  • Slo3 3 4
  • KCa5 3 4
  • Potassium Channel Subfamily U Member 1 3
  • KCa5.1 3

External Ids for KCNU1 Gene

Previous GeneCards Identifiers for KCNU1 Gene

  • GC08U990155
  • GC08P036761
  • GC08P036641
  • GC08P035176

Summaries for KCNU1 Gene

Entrez Gene Summary for KCNU1 Gene

  • This gene encodes a member of the potassium channel family of proteins. The encoded voltage-gated ion channel allows the outward flow of potassium ions during plasma membrane hyperpolarization in sperm. Opening of this channel may be regulated by calcium ion levels. Homozygous knockout mice that lack the related mouse gene exhibit male sterility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for KCNU1 Gene

KCNU1 (Potassium Calcium-Activated Channel Subfamily U Member 1) is a Protein Coding gene. Among its related pathways are Vascular smooth muscle contraction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include ion channel activity and potassium channel activity. An important paralog of this gene is KCNMA1.

UniProtKB/Swiss-Prot for KCNU1 Gene

  • Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina.

Tocris Summary for KCNU1 Gene

  • Calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).

Gene Wiki entry for KCNU1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNU1 Gene

Genomics for KCNU1 Gene

Regulatory Elements for KCNU1 Gene

Enhancers for KCNU1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G036879 1.8 ENCODE 4.3 +96.6 96638 3.0 PKNOX1 JUN ZSCAN4 FEZF1 RFX5 HIC1 CTBP1 ZNF366 ZBTB48 NFYB KCNU1 TPT1P8 MRPS7P1
GH08G036950 0.5 ENCODE 14.4 +166.2 166243 1.1 SMARCA4 EBF1 MAFK KCNU1 LOC105379377 LOC105379375 LOC105379376
GH08G036900 1.1 FANTOM5 Ensembl ENCODE 4.2 +117.2 117224 2.3 ZNF263 BHLHE40 SCRT2 CREB1 FOS ZNF600 MNT ZNF703 KCNU1 TPT1P8 LOC105379375
GH08G037011 0.5 ENCODE 7.3 +227.5 227471 0.4 PRDM6 ZNF624 FEZF1 LOC105379377 KCNU1 RPL26P25 GC08M037070
GH08G036904 0.6 ENCODE 4.4 +121.0 120978 2.3 MAFF ZNF316 USF2 CEBPB FOS MAFK KCNU1 LOC105379375 TPT1P8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCNU1 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNU1 Gene

Chromosome:
8
Start:
36,784,324 bp from pter
End:
36,936,128 bp from pter
Size:
151,805 bases
Orientation:
Plus strand

Genomic View for KCNU1 Gene

Genes around KCNU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNU1 Gene

Proteins for KCNU1 Gene

  • Protein details for KCNU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MYU2-KCNU1_HUMAN
    Recommended name:
    Potassium channel subfamily U member 1
    Protein Accession:
    A8MYU2

    Protein attributes for KCNU1 Gene

    Size:
    1149 amino acids
    Molecular mass:
    129543 Da
    Quaternary structure:
    • Homotetramer; which constitutes the calcium-activated potassium channel. May interact with LRRC52; this interaction may change channel gating properties, such as shifting gating to more negative potentials at a given pH.

    Three dimensional structures from OCA and Proteopedia for KCNU1 Gene

neXtProt entry for KCNU1 Gene

Post-translational modifications for KCNU1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KCNU1 Gene

Domains & Families for KCNU1 Gene

Gene Families for KCNU1 Gene

Protein Domains for KCNU1 Gene

Suggested Antigen Peptide Sequences for KCNU1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MYU2

UniProtKB/Swiss-Prot:

KCNU1_HUMAN :
  • The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.
  • Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa5.1/KCNU1 sub-subfamily.
Domain:
  • The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.
  • The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium (By similarity).
  • The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel.
  • The C-terminal cytosolic region confers the pH-dependence.
Family:
  • Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa5.1/KCNU1 sub-subfamily.
genes like me logo Genes that share domains with KCNU1: view

Function for KCNU1 Gene

Molecular function for KCNU1 Gene

UniProtKB/Swiss-Prot Function:
Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina.

Gene Ontology (GO) - Molecular Function for KCNU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005249 voltage-gated potassium channel activity IEA,IBA --
GO:0005267 potassium channel activity IEA,TAS --
GO:0060072 large conductance calcium-activated potassium channel activity IBA --
genes like me logo Genes that share ontologies with KCNU1: view
genes like me logo Genes that share phenotypes with KCNU1: view

Animal Models for KCNU1 Gene

MGI Knock Outs for KCNU1:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNU1

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for KCNU1 Gene

Localization for KCNU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNU1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNU1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for KCNU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IEA --
GO:0008076 voltage-gated potassium channel complex IEA,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNU1: view

Pathways & Interactions for KCNU1 Gene

genes like me logo Genes that share pathways with KCNU1: view

Interacting Proteins for KCNU1 Gene

Gene Ontology (GO) - Biological Process for KCNU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0034220 ion transmembrane transport IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNU1: view

No data available for SIGNOR curated interactions for KCNU1 Gene

Drugs & Compounds for KCNU1 Gene

(9) Drugs for KCNU1 Gene - From: DGIdb, IUPHAR, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
tetraethylammonium Experimental Pharma Inhibitor 1
Iberiotoxin Pharma Inhibitor KCa channel blocker (big conductance) 0
Charybdotoxin Pharma Pore Blocker, blocker 0
NS004 Pharma Potentiation, Activator 0
NS1619 Pharma Activator 0

(1) Additional Compounds for KCNU1 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TRAM 34
289905-88-0

(5) Tocris Compounds for KCNU1 Gene

Compound Action Cas Number
Apamin KCa2 channel blocker (small conductance) 24345-16-2
CyPPA Activator of KCa2.2 and KCa2.3 channels 73029-73-9
Iberiotoxin KCa channel blocker (big conductance) 129203-60-7
Paxilline SERCA ATPase blocker. Also potent BKCa channel blocker 57186-25-1
TRAM 34 Potent and highly selective KCa3.1 channel blocker 289905-88-0
genes like me logo Genes that share compounds with KCNU1: view

Transcripts for KCNU1 Gene

mRNA/cDNA for KCNU1 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNU1 Gene

Potassium channel, subfamily U, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNU1 Gene

No ASD Table

Relevant External Links for KCNU1 Gene

GeneLoc Exon Structure for
KCNU1
ECgene alternative splicing isoforms for
KCNU1

Expression for KCNU1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNU1 Gene

mRNA differential expression in normal tissues according to GTEx for KCNU1 Gene

This gene is overexpressed in Testis (x47.9).

Protein differential expression in normal tissues from HIPED for KCNU1 Gene

This gene is overexpressed in Liver, secretome (52.0) and Neutrophil (17.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNU1 Gene



Protein tissue co-expression partners for KCNU1 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCNU1 Gene:

KCNU1

SOURCE GeneReport for Unigene cluster for KCNU1 Gene:

Hs.13861

mRNA Expression by UniProt/SwissProt for KCNU1 Gene:

A8MYU2-KCNU1_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with KCNU1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNU1 Gene

Orthologs for KCNU1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNU1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNU1 34 35
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia KCNU1 34 35
  • 81.48 (n)
cow
(Bos Taurus)
Mammalia KCNU1 34 35
  • 77.08 (n)
rat
(Rattus norvegicus)
Mammalia Kcnu1 34
  • 75.46 (n)
mouse
(Mus musculus)
Mammalia Kcnu1 34 16 35
  • 74.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KCNU1 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857499 34
  • 58.2 (n)
KCNU1 35
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNU1 35
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii KCNU1 35
  • 39 (a)
OneToOne
Species where no ortholog for KCNU1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNU1 Gene

ENSEMBL:
Gene Tree for KCNU1 (if available)
TreeFam:
Gene Tree for KCNU1 (if available)

Paralogs for KCNU1 Gene

Paralogs for KCNU1 Gene

(1) SIMAP similar genes for KCNU1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KCNU1: view

Variants for KCNU1 Gene

Sequence variations from dbSNP and Humsavar for KCNU1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000012784 -- 36,913,095(+) TTACT(A/G)TTATT intron-variant
rs1000022124 -- 36,898,721(+) TATGG(A/G)AGGGA intron-variant
rs1000028298 -- 36,847,310(+) CAAAT(C/T)GGGGT intron-variant
rs1000079206 -- 36,852,769(+) TAATC(C/T)GTCTT intron-variant
rs1000084816 -- 36,787,814(+) ATTAC(-/TAATTATA)TAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNU1 Gene

Variant ID Type Subtype PubMed ID
esv2736881 CNV deletion 23290073
esv3572673 CNV loss 25503493
esv992767 CNV insertion 20482838
nsv831288 CNV gain 17160897

Variation tolerance for KCNU1 Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.69; 95.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNU1 Gene

Human Gene Mutation Database (HGMD)
KCNU1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNU1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNU1 Gene

Disorders for KCNU1 Gene

Relevant External Links for KCNU1

Genetic Association Database (GAD)
KCNU1
Human Genome Epidemiology (HuGE) Navigator
KCNU1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNU1

No disorders were found for KCNU1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNU1 Gene

Publications for KCNU1 Gene

  1. Functional and structural analysis of the human SLO3 pH- and voltage- gated K+ channel. (PMID: 23129643) Leonetti M.D. … Mackinnon R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4 64
  4. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (PMID: 16382103) Wei A.D. … Wulff H. (Pharmacol. Rev. 2005) 2 3 64
  5. Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes. (PMID: 9452476) Schreiber M. … Salkoff L. (J. Biol. Chem. 1998) 3 4 64

Products for KCNU1 Gene

Sources for KCNU1 Gene

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