Aliases for KCNU1 Gene
External Ids for KCNU1 Gene
Previous GeneCards Identifiers for KCNU1 Gene
GeneCards Summary for KCNU1 Gene
KCNU1 (Potassium Channel, Subfamily U, Member 1) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Oxytocin signaling pathway. GO annotations related to this gene include ion channel activity and potassium channel activity. An important paralog of this gene is KCNT2.
UniProtKB/Swiss-Prot for KCNU1 Gene
Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina.
Calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).