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Aliases for KCNU1 Gene

Aliases for KCNU1 Gene

  • Potassium Channel, Subfamily U, Member 1 2 3
  • Slo3 3 4 6
  • Calcium-Activated Potassium Channel, Subfamily M Subunit Alpha-3 3 4
  • Calcium-Activated Potassium Channel Subunit Alpha-3 3 4
  • Slowpoke Homolog 3 3 4
  • Kcnma3 3 4
  • KCNMC1 3 4
  • KCa5 3 4
  • Potassium Channel Subfamily U Member 1 3
  • KCa5.1 3

External Ids for KCNU1 Gene

Summaries for KCNU1 Gene

GeneCards Summary for KCNU1 Gene

KCNU1 (Potassium Channel, Subfamily U, Member 1) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include voltage-gated potassium channel activity and large conductance calcium-activated potassium channel activity. An important paralog of this gene is KCNT2.

UniProtKB/Swiss-Prot for KCNU1 Gene

  • Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina.

Tocris Summary for KCNU1 Gene

  • Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes, SK, IK and BK channels, based on their conductance (small, intermediate and big conductance respectively). The small conductance KCa channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both play important roles in many processes involving Ca2+-dependent signalling in both electrically excitable and non-excitable cells. The BK family of KCa channels (also known as Slo or Maxi-K channels) are also voltage-sensitive and include KCa1.1 (Slo1), KCa4.1 (Slo2.2), KCa4.2 (Slo2.1) and KCa5.1 (Slo3). These channels do not require calmodulin for activation as they contain three direct bivalent cation binding sites.

Gene Wiki entry for KCNU1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNU1 Gene

Genomics for KCNU1 Gene

Genomic Location for KCNU1 Gene

Start:
36,784,324 bp from pter
End:
36,936,128 bp from pter
Size:
151,805 bases
Orientation:
Plus strand

Genomic View for KCNU1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNU1 Gene

Regulatory Elements for KCNU1 Gene

Proteins for KCNU1 Gene

  • Protein details for KCNU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MYU2-KCNU1_HUMAN
    Recommended name:
    Potassium channel subfamily U member 1
    Protein Accession:
    A8MYU2
    Secondary Accessions:

    Protein attributes for KCNU1 Gene

    Size:
    1149 amino acids
    Molecular mass:
    129543 Da
    Quaternary structure:
    • Homotetramer; which constitutes the calcium-activated potassium channel. May interact with LRRC52; this interaction may change channel gating properties, such as shifting gating to more negative potentials at a given pH.

    Three dimensional structures from OCA and Proteopedia for KCNU1 Gene

neXtProt entry for KCNU1 Gene

Proteomics data for KCNU1 Gene at MOPED

Post-translational modifications for KCNU1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNU1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNU1 Gene

Domains for KCNU1 Gene

Gene Families for KCNU1 Gene

HGNC:
  • KCN :Potassium channels
  • KCa :Voltage-gated ion channels / Potassium channels, calcium-activated
IUPHAR :

Protein Domains for KCNU1 Gene

Suggested Antigen Peptide Sequences for KCNU1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MYU2

UniProtKB/Swiss-Prot:

KCNU1_HUMAN
Domain:
  • The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.:
    • A8MYU2
  • The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium (By similarity).:
    • A8MYU2
  • The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel.:
    • A8MYU2
  • The C-terminal cytosolic region confers the pH-dependence.:
    • A8MYU2
  • Contains 1 RCK N-terminal domain.:
    • A8MYU2
Family:
  • Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa5.1/KCNU1 sub-subfamily.:
    • A8MYU2
genes like me logo Genes that share domains with KCNU1: view

Function for KCNU1 Gene

Molecular function for KCNU1 Gene

UniProtKB/Swiss-Prot Function: Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina.

Gene Ontology (GO) - Molecular Function for KCNU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005249 voltage-gated potassium channel activity IBA --
GO:0005267 potassium channel activity TAS --
GO:0015269 calcium-activated potassium channel activity --
GO:0060072 large conductance calcium-activated potassium channel activity IBA --
genes like me logo Genes that share ontologies with KCNU1: view

Phenotypes for KCNU1 Gene

MGI mutant phenotypes for KCNU1:
inferred from 3 alleles
GenomeRNAi human phenotypes for KCNU1:
genes like me logo Genes that share phenotypes with KCNU1: view

Animal Models for KCNU1 Gene

MGI Knock Outs for KCNU1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNU1 Gene

Localization for KCNU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNU1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNU1 Gene COMPARTMENTS Subcellular localization image for KCNU1 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for KCNU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with KCNU1: view

Pathways for KCNU1 Gene

genes like me logo Genes that share pathways with KCNU1: view

Interacting Proteins for KCNU1 Gene

Gene Ontology (GO) - Biological Process for KCNU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport --
GO:0007338 single fertilization TAS --
GO:0032504 multicellular organism reproduction TAS --
GO:0034220 ion transmembrane transport --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNU1: view

Compounds for KCNU1 Gene

(5) Tocris Compounds for KCNU1 Gene

Compound Action Cas Number
Apamin KCa2 channel blocker (small conductance) [24345-16-2]
CyPPA Activator of KCa2.2 and KCa2.3 channels [73029-73-9]
Iberiotoxin KCa channel blocker (big conductance) [129203-60-7]
Paxilline SERCA ATPase blocker. Also potent BKCa channel blocker [57186-25-1]
TRAM 34 Highly selective KCa3.1 channel blocker [289905-88-0]

(1) HMDB Compounds for KCNU1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(5) IUPHAR Ligand for KCNU1 Gene

Ligand Type Action Affinity Pubmed IDs
iberiotoxin Inhibitor None
tetraethylammonium Inhibitor None
NS1619 Activator None
charybdotoxin Inhibitor None
NS004 Activator Potentiation
genes like me logo Genes that share compounds with KCNU1: view

Transcripts for KCNU1 Gene

mRNA/cDNA for KCNU1 Gene

(7) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNU1 Gene

Potassium channel, subfamily U, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNU1 Gene

No ASD Table

Relevant External Links for KCNU1 Gene

GeneLoc Exon Structure for
KCNU1
ECgene alternative splicing isoforms for
KCNU1

Expression for KCNU1 Gene

mRNA expression in normal human tissues for KCNU1 Gene

mRNA differential expression in normal tissues according to GTEx for KCNU1 Gene

This gene is overexpressed in Testis (47.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNU1 Gene

SOURCE GeneReport for Unigene cluster for KCNU1 Gene Hs.13861

mRNA Expression by UniProt/SwissProt for KCNU1 Gene

A8MYU2-KCNU1_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expressions with KCNU1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KCNU1 Gene

Orthologs for KCNU1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNU1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNU1 35
  • 99.25 (n)
  • 98.69 (a)
KCNU1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNU1 35
  • 77.08 (n)
  • 70.79 (a)
KCNU1 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNU1 35
  • 81.48 (n)
  • 75.92 (a)
KCNU1 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnu1 35
  • 74.45 (n)
  • 68.27 (a)
Kcnu1 16
Kcnu1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNU1 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnu1 35
  • 75.46 (n)
  • 69.77 (a)
chicken
(Gallus gallus)
Aves KCNU1 36
  • 44 (a)
OneToOne
LOC100857499 35
  • 58.2 (n)
  • 50.05 (a)
lizard
(Anolis carolinensis)
Reptilia KCNU1 36
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii KCNU1 36
  • 39 (a)
OneToOne
Species with no ortholog for KCNU1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNU1 Gene

ENSEMBL:
Gene Tree for KCNU1 (if available)
TreeFam:
Gene Tree for KCNU1 (if available)

Paralogs for KCNU1 Gene

Paralogs for KCNU1 Gene

Selected SIMAP similar genes for KCNU1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KCNU1: view

Variants for KCNU1 Gene

Sequence variations from dbSNP and Humsavar for KCNU1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs719674 -- 36,903,466(-) TGTGT(A/G)TCACA intron-variant
rs725680 -- 36,866,801(-) TGCTG(C/T)CAAAA intron-variant
rs970968 -- 36,897,887(-) TCCCC(A/G)TCTGT intron-variant
rs996351 -- 36,861,484(-) ATTTA(C/T)GTATC intron-variant
rs1005583 -- 36,929,635(-) GGTTC(A/G)TCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNU1 Gene

Variant ID Type Subtype PubMed ID
nsv831288 CNV Gain 17160897
esv2736881 CNV Deletion 23290073
esv992767 CNV Insertion 20482838

Relevant External Links for KCNU1 Gene

HapMap Linkage Disequilibrium report
KCNU1
Human Gene Mutation Database (HGMD)
KCNU1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNU1 Gene

Disorders for KCNU1 Gene

Relevant External Links for KCNU1

Genetic Association Database (GAD)
KCNU1
Human Genome Epidemiology (HuGE) Navigator
KCNU1
genes like me logo Genes that share disorders with KCNU1: view

No data available for UniProtKB/Swiss-Prot for KCNU1 Gene

Publications for KCNU1 Gene

  1. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (PMID: 16382103) Wei A.D. … Wulff H. (Pharmacol. Rev. 2005) 2 3
  2. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes. (PMID: 9452476) Schreiber M. … Salkoff L. (J. Biol. Chem. 1998) 3 4
  5. Functional and structural analysis of the human SLO3 pH- and voltage- gated K+ channel. (PMID: 23129643) Leonetti M.D. … Mackinnon R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4

Products for KCNU1 Gene

Sources for KCNU1 Gene

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