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Aliases for KCNT2 Gene

Aliases for KCNT2 Gene

  • Potassium Sodium-Activated Channel Subfamily T Member 2 2 3
  • Potassium Channel, Sodium Activated Subfamily T, Member 2 2 3 5
  • Sodium And Chloride-Activated ATP-Sensitive Potassium Channel Slo2.1 3 4
  • Sequence Like An Intermediate Conductance Potassium Channel Subunit 3 4
  • Potassium Channel, Subfamily T, Member 2 2 3
  • SLICK 3 4
  • Sodium-And Chloride-Activated ATP-Sensitive Potassium Channel (SLICK) 3
  • Sodium And Chloride Activated ATP Sensitive Potassium Channel 2
  • KCa4.2 3
  • SLO2.1 3

External Ids for KCNT2 Gene

Previous GeneCards Identifiers for KCNT2 Gene

  • GC01M193941
  • GC01U900041
  • GC01M192927
  • GC01M194461
  • GC01M167436

Summaries for KCNT2 Gene

GeneCards Summary for KCNT2 Gene

KCNT2 (Potassium Sodium-Activated Channel Subfamily T Member 2) is a Protein Coding gene. Among its related pathways are Hepatic ABC Transporters and Sweet Taste Signaling. GO annotations related to this gene include voltage-gated potassium channel activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNU1.

UniProtKB/Swiss-Prot for KCNT2 Gene

  • Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1.

Tocris Summary for KCNT2 Gene

  • Calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).

Gene Wiki entry for KCNT2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNT2 Gene

Genomics for KCNT2 Gene

Regulatory Elements for KCNT2 Gene

Promoters for KCNT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KCNT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNT2 Gene

Chromosome:
1
Start:
196,225,779 bp from pter
End:
196,609,225 bp from pter
Size:
383,447 bases
Orientation:
Minus strand

Genomic View for KCNT2 Gene

Genes around KCNT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNT2 Gene

Proteins for KCNT2 Gene

  • Protein details for KCNT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UVM3-KCNT2_HUMAN
    Recommended name:
    Potassium channel subfamily T member 2
    Protein Accession:
    Q6UVM3
    Secondary Accessions:
    • Q3SY59
    • Q5VTN1
    • Q6ZMT3

    Protein attributes for KCNT2 Gene

    Size:
    1135 amino acids
    Molecular mass:
    130501 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KCNT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNT2 Gene

Proteomics data for KCNT2 Gene at MOPED

Post-translational modifications for KCNT2 Gene

  • Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain inhibits channel activity.
  • Glycosylation at Asn 99
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNT2 Gene

No data available for DME Specific Peptides for KCNT2 Gene

Domains & Families for KCNT2 Gene

Gene Families for KCNT2 Gene

Protein Domains for KCNT2 Gene

Suggested Antigen Peptide Sequences for KCNT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UVM3

UniProtKB/Swiss-Prot:

KCNT2_HUMAN :
  • Contains 1 RCK N-terminal domain.
  • Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.2/KCNT2 sub-subfamily.
Domain:
  • Contains 1 RCK N-terminal domain.
Family:
  • Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.2/KCNT2 sub-subfamily.
genes like me logo Genes that share domains with KCNT2: view

Function for KCNT2 Gene

Molecular function for KCNT2 Gene

UniProtKB/Swiss-Prot Function:
Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1.

Gene Ontology (GO) - Molecular Function for KCNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005249 voltage-gated potassium channel activity IBA --
genes like me logo Genes that share ontologies with KCNT2: view
genes like me logo Genes that share phenotypes with KCNT2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNT2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNT2 Gene

Localization for KCNT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNT2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNT2 Gene COMPARTMENTS Subcellular localization image for KCNT2 gene
Compartment Confidence
plasma membrane 5
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for KCNT2 Gene

Pathways & Interactions for KCNT2 Gene

genes like me logo Genes that share pathways with KCNT2: view

Pathways by source for KCNT2 Gene

Interacting Proteins for KCNT2 Gene

Gene Ontology (GO) - Biological Process for KCNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport IEA --
genes like me logo Genes that share ontologies with KCNT2: view

No data available for SIGNOR curated interactions for KCNT2 Gene

Drugs & Compounds for KCNT2 Gene

(10) Drugs for KCNT2 Gene - From: IUPHAR, DGIdb, Tocris, PharmGKB, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
tetraethylammonium Experimental Pharma Inhibitor 1
Ba<sup>2+</sup> Pharma Pore Blocker 0
charybdotoxin Pharma Pore Blocker, blocker 0
iberiotoxin Pharma Inhibitor 0
NS004 Pharma Potentiation, Activator 0

(6) Additional Compounds for KCNT2 Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
sodium
  • Sodium
  • Sodium ion
7440-23-5
1-EBIO
10045-45-1
BMS 191011
202821-81-6
DCEBIO
60563-36-2
genes like me logo Genes that share compounds with KCNT2: view

Transcripts for KCNT2 Gene

Unigene Clusters for KCNT2 Gene

Potassium channel, subfamily T, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNT2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1: -
SP2: -

ExUns: 27 ^ 28a · 28b
SP1:
SP2:

Relevant External Links for KCNT2 Gene

GeneLoc Exon Structure for
KCNT2
ECgene alternative splicing isoforms for
KCNT2

Expression for KCNT2 Gene

mRNA expression in normal human tissues for KCNT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNT2 Gene

This gene is overexpressed in Artery - Coronary (x4.1).

Protein differential expression in normal tissues from HIPED for KCNT2 Gene

This gene is overexpressed in Skin (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNT2 Gene



SOURCE GeneReport for Unigene cluster for KCNT2 Gene Hs.657046

genes like me logo Genes that share expression patterns with KCNT2: view

Protein tissue co-expression partners for KCNT2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KCNT2 Gene

Orthologs for KCNT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNT2 35
  • 99.82 (n)
  • 100 (a)
KCNT2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNT2 36
  • 94 (a)
OneToOne
KCNT2 35
  • 92.77 (n)
  • 97.95 (a)
dog
(Canis familiaris)
Mammalia KCNT2 35
  • 94.27 (n)
  • 98.06 (a)
KCNT2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnt2 16
Kcnt2 35
  • 90.46 (n)
  • 97.53 (a)
Kcnt2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNT2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Kcnt2 35
  • 90.43 (n)
  • 97.53 (a)
chicken
(Gallus gallus)
Aves KCNT2 35
  • 83.7 (n)
  • 91.89 (a)
KCNT2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNT2 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnt1 35
  • 68.85 (n)
  • 76.53 (a)
zebrafish
(Danio rerio)
Actinopterygii kcnt2 36
  • 63 (a)
OneToOne
LOC565691 35
  • 68.67 (n)
  • 78.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42732 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea slo-2 36
  • 43 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for KCNT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNT2 Gene

ENSEMBL:
Gene Tree for KCNT2 (if available)
TreeFam:
Gene Tree for KCNT2 (if available)

Paralogs for KCNT2 Gene

Paralogs for KCNT2 Gene

(1) SIMAP similar genes for KCNT2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KCNT2: view

Variants for KCNT2 Gene

Sequence variations from dbSNP and Humsavar for KCNT2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_037527 A breast cancer sample
rs12738104 - 196,398,618(+) AAAGG(A/C)CAATT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs12742082 - 196,398,570(+) GCAAA(A/T)TTGAT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs558895 -- 196,273,634(-) AAGCC(A/C)TACGA intron-variant
rs631216 -- 196,255,063(+) TACTA(A/G)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNT2 Gene

Variant ID Type Subtype PubMed ID
nsv872948 CNV Gain 21882294
nsv872952 CNV Gain 21882294
nsv832237 CNV Gain 17160897
nsv469680 CNV Complex 16826518
nsv872953 CNV Loss 21882294
nsv872954 CNV Loss 21882294
nsv872955 CNV Loss 21882294
dgv493n71 CNV Loss 21882294
esv1430984 CNV Insertion 17803354
esv2720973 CNV Deletion 23290073
nsv508685 CNV Loss 20534489
nsv528460 CNV Gain 19592680
esv2720984 CNV Deletion 23290073
esv1933670 CNV Deletion 18987734

Variation tolerance for KCNT2 Gene

Residual Variation Intolerance Score: 1.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNT2 Gene

HapMap Linkage Disequilibrium report
KCNT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNT2 Gene

Disorders for KCNT2 Gene

Relevant External Links for KCNT2

Genetic Association Database (GAD)
KCNT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNT2

No disorders were found for KCNT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNT2 Gene

Publications for KCNT2 Gene

  1. Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP. (PMID: 14684870) Bhattacharjee A. … Kaczmarek L.K. (J. Neurosci. 2003) 3 4 23 67
  2. Opposite regulation of Slick and Slack K+ channels by neuromodulators. (PMID: 16687497) Santi C.M. … Salkoff L. (J. Neurosci. 2006) 3 23
  3. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (PMID: 16382103) Wei A.D. … Wulff H. (Pharmacol. Rev. 2005) 2 3
  4. Identification of the Intracellular Na+ Sensor in Slo2.1 Potassium Channels. (PMID: 25903137) Thomson S.J. … Sanguinetti M.C. (J. Biol. Chem. 2015) 3
  5. Cell volume changes regulate slick (Slo2.1), but not slack (Slo2.2) K+ channels. (PMID: 25347289) Tejada M.A. … Klaerke D.A. (PLoS ONE 2014) 3

Products for KCNT2 Gene

Sources for KCNT2 Gene

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