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Aliases for KCNT2 Gene

Aliases for KCNT2 Gene

  • Potassium Channel, Sodium Activated Subfamily T, Member 2 2 3
  • SLICK 3 4 6
  • Sodium And Chloride-Activated ATP-Sensitive Potassium Channel Slo2.1 3 4
  • Sequence Like An Intermediate Conductance Potassium Channel Subunit 3 4
  • Potassium Channel, Subfamily T, Member 2 2 3
  • Sodium-And Chloride-Activated ATP-Sensitive Potassium Channel (SLICK) 3
  • Sodium And Chloride Activated ATP Sensitive Potassium Channel 2
  • Potassium Channel Subfamily T Member 2 3
  • KCa4.2 3
  • SLO2.1 3

External Ids for KCNT2 Gene

Summaries for KCNT2 Gene

GeneCards Summary for KCNT2 Gene

KCNT2 (Potassium Channel, Sodium Activated Subfamily T, Member 2) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include voltage-gated potassium channel activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNU1.

UniProtKB/Swiss-Prot for KCNT2 Gene

  • Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1.

Tocris Summary for KCNT2 Gene

  • Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes, SK, IK and BK channels, based on their conductance (small, intermediate and big conductance respectively). The small conductance KCa channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both play important roles in many processes involving Ca2+-dependent signalling in both electrically excitable and non-excitable cells. The BK family of KCa channels (also known as Slo or Maxi-K channels) are also voltage-sensitive and include KCa1.1 (Slo1), KCa4.1 (Slo2.2), KCa4.2 (Slo2.1) and KCa5.1 (Slo3). These channels do not require calmodulin for activation as they contain three direct bivalent cation binding sites.

Gene Wiki entry for KCNT2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNT2 Gene

Genomics for KCNT2 Gene

Genomic Location for KCNT2 Gene

Start:
196,225,779 bp from pter
End:
196,609,225 bp from pter
Size:
383,447 bases
Orientation:
Minus strand

Genomic View for KCNT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNT2 Gene

Regulatory Elements for KCNT2 Gene

Proteins for KCNT2 Gene

  • Protein details for KCNT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UVM3-KCNT2_HUMAN
    Recommended name:
    Potassium channel subfamily T member 2
    Protein Accession:
    Q6UVM3
    Secondary Accessions:
    • Q3SY59
    • Q5VTN1
    • Q6ZMT3

    Protein attributes for KCNT2 Gene

    Size:
    1135 amino acids
    Molecular mass:
    130501 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KCNT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNT2 Gene

Proteomics data for KCNT2 Gene at MOPED

Post-translational modifications for KCNT2 Gene

  • Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain inhibits channel activity.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn99

Other Protein References for KCNT2 Gene

No data available for DME Specific Peptides for KCNT2 Gene

Domains for KCNT2 Gene

Gene Families for KCNT2 Gene

HGNC:
  • KCN :Potassium channels
  • KCa :Voltage-gated ion channels / Potassium channels, calcium-activated
IUPHAR :

Protein Domains for KCNT2 Gene

UniProtKB/Swiss-Prot:

KCNT2_HUMAN
Domain:
  • Contains 1 RCK N-terminal domain.:
    • Q6UVM3
Family:
  • Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.2/KCNT2 sub-subfamily.:
    • Q6UVM3
genes like me logo Genes that share domains with KCNT2: view

Function for KCNT2 Gene

Molecular function for KCNT2 Gene

UniProtKB/Swiss-Prot Function: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1.

Gene Ontology (GO) - Molecular Function for KCNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005249 voltage-gated potassium channel activity IBA --
GO:0005524 ATP binding IEA --
GO:0015269 calcium-activated potassium channel activity IBA --
genes like me logo Genes that share ontologies with KCNT2: view

Phenotypes for KCNT2 Gene

GenomeRNAi human phenotypes for KCNT2:
genes like me logo Genes that share phenotypes with KCNT2: view

miRNA for KCNT2 Gene

miRTarBase miRNAs that target KCNT2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KCNT2 Gene

Localization for KCNT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNT2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNT2 Gene COMPARTMENTS Subcellular localization image for KCNT2 gene
Compartment Confidence
plasma membrane 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008076 voltage-gated potassium channel complex IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with KCNT2: view

Pathways for KCNT2 Gene

genes like me logo Genes that share pathways with KCNT2: view

Interacting Proteins for KCNT2 Gene

Gene Ontology (GO) - Biological Process for KCNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport --
GO:0071805 potassium ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with KCNT2: view

Compounds for KCNT2 Gene

(5) Tocris Compounds for KCNT2 Gene

Compound Action Cas Number
Apamin KCa2 channel blocker (small conductance) [24345-16-2]
CyPPA Activator of KCa2.2 and KCa2.3 channels [73029-73-9]
Iberiotoxin KCa channel blocker (big conductance) [129203-60-7]
Paxilline SERCA ATPase blocker. Also potent BKCa channel blocker [57186-25-1]
TRAM 34 Highly selective KCa3.1 channel blocker [289905-88-0]

(3) HMDB Compounds for KCNT2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Chlorine
  • Cl2
16887-00-6
Sodium
  • Sodium
7440-23-5

(7) IUPHAR Ligand for KCNT2 Gene

Ligand Type Action Affinity Pubmed IDs
phorbol 12-myristate 13-acetate Activator None
Ba2+ Pore Blocker Antagonist
iberiotoxin Inhibitor None
tetraethylammonium Inhibitor None
NS1619 Activator None
charybdotoxin Inhibitor None
NS004 Activator Potentiation
genes like me logo Genes that share compounds with KCNT2: view

Transcripts for KCNT2 Gene

Unigene Clusters for KCNT2 Gene

Potassium channel, subfamily T, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNT2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1: -
SP2: -

ExUns: 27 ^ 28a · 28b
SP1:
SP2:

Relevant External Links for KCNT2 Gene

GeneLoc Exon Structure for
KCNT2
ECgene alternative splicing isoforms for
KCNT2

Expression for KCNT2 Gene

mRNA expression in normal human tissues for KCNT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNT2 Gene

This gene is overexpressed in Artery - Coronary (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KCNT2 Gene

SOURCE GeneReport for Unigene cluster for KCNT2 Gene Hs.657046

genes like me logo Genes that share expressions with KCNT2: view

Orthologs for KCNT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNT2 36
  • 99.82 (n)
  • 100 (a)
KCNT2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNT2 36
  • 92.77 (n)
  • 97.95 (a)
KCNT2 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNT2 36
  • 94.27 (n)
  • 98.06 (a)
KCNT2 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnt2 36
  • 90.46 (n)
  • 97.53 (a)
Kcnt2 16
Kcnt2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNT2 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 81 (a)
OneToMany
-- 37
  • 86 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
-- 37
  • 92 (a)
OneToMany
-- 37
  • 97 (a)
OneToMany
-- 37
  • 95 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Kcnt2 36
  • 90.43 (n)
  • 97.53 (a)
chicken
(Gallus gallus)
Aves KCNT2 36
  • 83.7 (n)
  • 91.89 (a)
KCNT2 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNT2 37
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnt1 36
  • 68.85 (n)
  • 76.53 (a)
zebrafish
(Danio rerio)
Actinopterygii kcnt2 37
  • 63 (a)
OneToOne
LOC565691 36
  • 68.67 (n)
  • 78.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42732 37
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea slo-2 37
  • 43 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
OneToOne
Species with no ortholog for KCNT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNT2 Gene

ENSEMBL:
Gene Tree for KCNT2 (if available)
TreeFam:
Gene Tree for KCNT2 (if available)

Paralogs for KCNT2 Gene

Paralogs for KCNT2 Gene

Selected SIMAP similar genes for KCNT2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KCNT2: view

Variants for KCNT2 Gene

Sequence variations from dbSNP and Humsavar for KCNT2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs533228 -- 196,265,193(-) cattg(C/T)ctaga intron-variant
rs553761 -- 196,279,696(-) AATCC(C/T)AGCAC intron-variant
rs558895 -- 196,273,634(-) AAGCC(A/C)TACGA intron-variant
rs564157 -- 196,266,221(+) gagac(G/T)caccc intron-variant
rs588211 -- 196,257,759(+) ACATA(A/C)ACTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNT2 Gene

Variant ID Type Subtype PubMed ID
nsv872948 CNV Gain 21882294
nsv872952 CNV Gain 21882294
nsv832237 CNV Gain 17160897
nsv469680 CNV Complex 16826518
nsv872953 CNV Loss 21882294
nsv872954 CNV Loss 21882294
nsv872955 CNV Loss 21882294
dgv493n71 CNV Loss 21882294
esv1430984 CNV Insertion 17803354
esv2720973 CNV Deletion 23290073
nsv508685 CNV Loss 20534489
nsv528460 CNV Gain 19592680
esv2720984 CNV Deletion 23290073
esv1933670 CNV Deletion 18987734

Relevant External Links for KCNT2 Gene

HapMap Linkage Disequilibrium report
KCNT2

Disorders for KCNT2 Gene

Relevant External Links for KCNT2

Genetic Association Database (GAD)
KCNT2
genes like me logo Genes that share disorders with KCNT2: view

No data available for UniProtKB/Swiss-Prot for KCNT2 Gene

Publications for KCNT2 Gene

  1. Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP. (PMID: 14684870) Bhattacharjee A. … Kaczmarek L.K. (J. Neurosci. 2003) 3 4 23
  2. Opposite regulation of Slick and Slack K+ channels by neuromodulators. (PMID: 16687497) Santi C.M. … Salkoff L. (J. Neurosci. 2006) 3 4 23
  3. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (PMID: 16382103) Wei A.D. … Wulff H. (Pharmacol. Rev. 2005) 2 3
  4. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney S.J. … . (Mol. Psychiatry 2011) 3
  5. Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis. (PMID: 23577725) Naj A.C. … Pericak-Vance M.A. (Ann. Hum. Genet. 2013) 3

Products for KCNT2 Gene

Sources for KCNT2 Gene

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