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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KCNT1 Gene

protein-coding GIFtS: 52
GCID: GC09P138594

potassium channel, subfamily T, member 1

Explore 11 diseases affiliated with
KCNT1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Potassium Channel, Subfamily T, Member 1¹ ²		ENFL5²
KCa4.1¹ ² ³		SLACK²
KIAA1422¹ ³ ⁵		BA100C15.2¹
EIEE14²		Potassium Channel Subfamily T Member 1²

External Ids:	HGNC: 18865¹	Entrez Gene: 57582²	Ensembl: ENSG00000107147⁷	OMIM: 608167⁵	UniProtKB: Q5JUK3³

Export aliases for KCNT1 gene to outside databases

Previous GC identifers: GC09P129743 GC09P130365 GC09P132117 GC09P134032 GC09P134033 GC09P135819 GC09P137733 GC09P108055

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNT1:

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural

standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion,

neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes

a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental

signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial

seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple

transcript variants. (provided by RefSeq, Dec 2012)

UniProtKB/Swiss-Prot: KCNT1_HUMAN, Q5JUK3

Function: Outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits.

Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors,

such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity)

summary for KCNT1:

Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+

ions across biological membranes. They are broadly classified into three subtypes, SK, IK and BK channels,

based on their conductance (small, intermediate and big conductance respectively). The small conductance KCa

channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance

KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both

play important roles in many processes involving Ca2+-dependent signalling in both electrically excitable

and non-excitable cells. The BK family of KCa channels (also known as Slo or Maxi-K channels) are also

voltage-sensitive and include KCa1.1 (Slo1), KCa4.1 (Slo2.2), KCa4.2 (Slo2.1) and KCa5.1 (Slo3). These

channels do not require calmodulin for activation as they contain three direct bivalent cation binding

sites.

Gene Wiki entry for KCNT1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_019501.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KCNT1 gene promoter:
NF-1 NF-1/L p53 MyoD AP-4 Nkx2-5 LUN-1 NF-kappaB S8 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNT1 promoter sequence

Search SABiosciences Chromatin IP Primers for KCNT1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNT1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3

KCNT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNT1 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P138594: view genomic region (about GC identifiers)

Start:	138,594,031 bp from pter	End:	138,684,993 bp from pter
Size:	90,963 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KCNT1_HUMAN, Q5JUK3 (See protein sequence)

Recommended Name: Potassium channel subfamily T member 1

Size: 1230 amino acids; 138343 Da

Subunit: Interacts with CRBN via its cytoplasmic C-terminus (By similarity)

Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)

Sequence caution: Sequence=BAA92660.1; Type=Erroneous initiation; Sequence=CAI39240.1; Type=Erroneous initiation;

Secondary accessions: B7ZVY4 B9EGP2 Q9P2C5

Alternative splicing: 3 isoforms: Q5JUK3-1 Q5JUK3-2 Q5JUK3-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KCNT1: NX_Q5JUK3

Post-translational modifications:

Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5JUK3

KCNT1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001258932.1 NP_065873.2

ENSEMBL proteins:

ENSP00000417851 ENSP00000360822 ENSP00000418777 ENSP00000420764 ENSP00000417578

ENSP00000419086 ENSP00000419007 ENSP00000418003 ENSP00000298480 ENSP00000263604

Human Recombinant Protein Products for KCNT1:

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	Uscn Proteins for KCNT1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008076	voltage-gated potassium channel complex	IBA	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	--	--

KCNT1 for ontologies About GeneDecksing

KCNT1 Antibody Products:

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	Uscn ELISAs and CLIAs for KCNT1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KCNT1 for domains About GeneDecksing

3 InterPro domains/families:

IPR016040 NAD(P)-bd_dom

IPR013099 Ion_trans_2

IPR003929 K_chnl_Ca-activ_BK_asu

Graphical View of Domain Structure for InterPro Entry Q5JUK3

ProtoNet protein and cluster: Q5JUK3

1 Blocks protein family: IPB013099 Ion transport 2

UniProtKB/Swiss-Prot: KCNT1_HUMAN, Q5JUK3

Similarity: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1

sub-subfamily

Similarity: Contains 1 RCK N-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: KCNT1_HUMAN, Q5JUK3

Function: Outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits.

Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors,

such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity)

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005249	voltage-gated potassium channel activity	IBA	--
GO:0005267	potassium channel activity	--	--
GO:0015269	calcium-activated potassium channel activity	IBA	--

KCNT1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for KCNT1:

Increased Salmonella enterica

Increased gamma-H2AX phosphory

1 MGI phenotypic allele

for Kcnt1 (no phenotypes)

KCNT1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Kcnt1^tm1Lex for KCNT1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for KCNT1

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		hsa-miR-633 hsa-miR-4311 hsa-miR-218 hsa-miR-636
		SwitchGear 3'UTR luciferase reporter plasmid: KCNT1 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNT1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Sweet Taste Signaling

Sweet Taste Signaling	1.00	Bitter Taste Signaling	0.44
Melatonin Signaling	0.72	Sperm Motility	0.36
Cellular Effects of Sildenafil	0.46

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			PKA Signaling	0.56
	cAMP Pathway	0.77

Neuropathic Pain-Signaling in Dorsal Horn Neurons

	Neuropathic Pain-Signaling in Dorsal Horn Neurons	1.00			Cholera Infection	0.40
	Aldosterone Signaling in Epithelial Cells	0.47

Hepatic ABC Transporters

Hepatic ABC Transporters

1.00

MODY (Maturity-Onset Diabetes of Young)

0.41

5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCNT1 (see all 13)

	Cholera Infection
	Neuropathic Pain-Signaling in Dorsal Horn Neurons
	Hepatic ABC Transporters
	PKA Signaling
	Sweet Taste Signaling

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KCNT1

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006813	potassium ion transport	--	--
GO:0071805	potassium ion transmembrane transport	IBA	--

KCNT1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for KCNT1 available from Tocris Bioscience About this table

Compound	Action	CAS #
YS-035 hydrochloride	Inhibits K+ outward/pacemaker current	[33978-72-2]
DMP 543	K+ channel blocker and potent ACh release enhancer	[160588-45-4]
		--
4-Aminopyridine	Non-selective KV channel blocker	[504-24-5]

3 HMDB Compounds for KCNT1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Chlorine	Cl2 (see all 13)	16887-00-6	--
Sodium	Sodium (see all 2)	7440-23-5	--

Search CenterWatch for drugs/clinical trials and news about KCNT1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KCNT1 gene (2 alternative transcripts):

NM_001272003.1 NM_020822.2

Unigene Cluster for KCNT1:

Potassium channel, subfamily T, member 1

Hs.104950 [show with all ESTs]

Unigene Representative Sequence: NM_020822

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000487664(uc010nbf.3) ENST00000371757 ENST00000460750(uc011mdr.2)

ENST00000473941 ENST00000486577 ENST00000491806 ENST00000488444 ENST00000490355

ENST00000490363(uc004cgo.1) ENST00000475008 ENST00000298480(uc011mdq.2)

ENST00000263604

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		hsa-miR-633 hsa-miR-4311 hsa-miR-218 hsa-miR-636
		SwitchGear 3'UTR luciferase reporter plasmid: KCNT1 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNT1

Additional cDNA sequence:

AB037843.1 AK123276.1 AK124588.1 AK127272.1 BC136618.1 BC144304.1 BC171770.1

5 DOTS entries:

DT.40262013 DT.101981724 DT.97788661 DT.101981723 DT.100773373

18 AceView cDNA sequences:

BE260717 BX110871 AB037843 BM547545 BC035730 AK127272 AK123276 BQ721148

AA442216 BM925808 BF315953 AK124588 BF311848 BX375126 BX331632 R87855

BF363321 BF207020

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KCNT1 (see all 7) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	·	11c	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17	^	18	^	19a	·	19b	^
SP1:			-								-																-
SP2:											-																-
SP3:
SP4:
SP5:

ExUns:	20	^	21	^	22a	·	22b	^	23	^	24	^	25	^	26	^	27	^	28	^	29	^	30a	·	30b	^	31a	·	31b
SP1:					-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for KCNT1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCNT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

KCNT1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Brain

Neural Tube

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KCNT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNT1

SOURCE GeneReport for Unigene cluster: Hs.104950

UniProtKB/Swiss-Prot: KCNT1_HUMAN, Q5JUK3

Tissue specificity: Highest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle

SABiosciences Custom PCR Arrays for KCNT1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KCNT1 gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KCNT1¹	potassium channel, subfamily T, member 1	85.1(n) 90.55(a)		395248 NM_204562.1 NP_989893.1
lizard (Anolis carolinensis)	Reptilia	KCNT1⁶	--	84(a)	1 ↔ 1	GL343625.1(302078-374608)
zebrafish (Danio rerio)	Actinopterygii	kcnt1¹	potassium channel, subfamily T, member 1	71.45(n) 78.18(a)		100004419 XM_001920597.2 XP_001920632.2
fruit fly (Drosophila melanogaster)	Insecta	CG42732¹	CG42732	62.25(n) 58.13(a)		5740325 NM_001103789.2 NP_001097259.2
worm (Caenorhabditis elegans)	Secernentea	slo-2¹	Protein SLO-2	51.19(n) 48.26(a)		181332 NM_001136452.1 NP_001129924.1

ENSEMBL Gene Tree for KCNT1 (if available)
TreeFam Gene Tree for KCNT1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KCNT1 gene

KCNMA1² KCNT2² KCNU1²

1 SIMAP similar gene for KCNT1 using alignment to 8 protein entries: KCNT1_HUMAN (see all proteins):

KCNT2

KCNT1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73667686^1,2	C	--	138592064(+)	`CACTCT/CCAACA`	3	--	us2k¹		3		WA EA	240
rs114454133^1,2	F	--	138592073(+)	`CAGGTT/GTCTGC`	3	--	us2k¹		1		WA	118
rs187815438^1,2		--	138592093(+)	`GGGGTC/TCTGCC`	3	--	us2k¹		0	--	--	--	--
rs145641800^1,2		--	138592258(+)	`GTTGC-/GGGGGG`	3	--	us2k¹		0	--	--	--	--
rs142523190^1,2		--	138592293(+)	`GGGTGC/GGGGGT`	3	--	us2k¹		0	--	--	--	--
rs192641777^1,2		--	138592348(+)	`AGGTCA/GTAGCG`	3	--	us2k¹		0	--	--	--	--
rs480045^1,2	C,A	--	138592368(-)	`CCACCT/CACCCC`	3	--	us2k¹ tfbs³		10		NA WA CSA EA	369
rs146005819^1,2		--	138592569(+)	`GTGGTG/TTCTCC`	3	--	us2k¹		0	--	--	--	--
rs73667687^1,2	C	--	138592758(+)	`TCCCTA/GAAGCC`	3	--	us2k¹		2		WA EA	122
rs148671325^1,2		--	138592763(+)	`AAAGCC/TCTCGG`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KCNT1 (138594031 - 138684993 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 19 variations for KCNT1
15/19 CNVs (see all 19): 30346 52755 52752 52745 30345 52744 52750 52751 30343 52746 52753 53672 52748 52749 52754
Human Gene Mutation Database (HGMD): KCNT1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KCNT1 for disorders           About GeneDecksing

OMIM gene information: 608167    OMIM disorders: --

11 diseases for KCNT1:    About MalaCards

generalized epilepsy and paroxysmal dyskinesia vitreous detachment cutis laxa follicular mucinosis

generalized epilepsy mycosis fungoides hypertropia intracranial aneurysm

tetanus pharyngitis neuronitis

2 diseases from the University of Copenhagen DISEASES database for KCNT1:

Form agnosia Cortical deafness

Export disorders for KCNT1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KCNT1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KCNT1)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2, 3} Nagase T.... Ohara O. (2000)
International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (PubMed id 16382103)^{1, 3} Wei A.D....Wulff H. (2005)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
Missense mutations in the sodium-gated potassium chann el gene KCNT1 cause severe autosomal dominant nocturnal frontal lobe epilepsy. (PubMed id 23086396)¹ Heron S.E....Dibbens L.M. (2012)
Genetics: mutations in potassium channel KCNT1-a novel driver of epilepsy pathogenesis. (PubMed id 23147853)¹ Kingwell K. (2012)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57582	HGNC: 18865	AceView: KCNT1	Ensembl:ENSG00000107147	euGenes: HUgn57582
ECgene: KCNT1	H-InvDB: KCNT1

(According to HUGE)
About This Section

HUGE: KIAA1422

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KCNT1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KCNT1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KCNT1 gene:
Search GeneIP for patents involving KCNT1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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potassium channel, subfamily T, member 1

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KCNT1 Gene

potassium channel, subfamily T, member 1

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