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Aliases for KCNS3 Gene

Aliases for KCNS3 Gene

  • Potassium Voltage-Gated Channel, Modifier Subfamily S, Member 3 2 3
  • Potassium Voltage-Gated Channel, Delayed-Rectifier, Subfamily S, Member 3 2 3
  • Delayed-Rectifier K(+) Channel Alpha Subunit 3 3 4
  • Voltage-Gated Potassium Channel Subunit Kv9.3 3 4
  • KV9.3 3 6
  • Potassium Voltage-Gated Channel Delayed-Rectifier Protein S3 3
  • Shab-Related Delayed-Rectifier K+ Channel Alpha Subunit 3 3
  • Potassium Voltage-Gated Channel Subfamily S Member 3 3
  • Voltage-Gated Potassium Channel Protein Kv9.3 3

External Ids for KCNS3 Gene

Summaries for KCNS3 Gene

Entrez Gene Summary for KCNS3 Gene

  • Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for KCNS3 Gene

KCNS3 (Potassium Voltage-Gated Channel, Modifier Subfamily S, Member 3) is a Protein Coding gene. Among its related pathways are Metabolism and Transmission across Chemical Synapses. GO annotations related to this gene include delayed rectifier potassium channel activity and potassium channel regulator activity. An important paralog of this gene is KCNB2.

UniProtKB/Swiss-Prot for KCNS3 Gene

  • Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity).

Tocris Summary for KCNS3 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNS3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNS3 Gene

Genomics for KCNS3 Gene

Genomic Location for KCNS3 Gene

Start:
17,877,847 bp from pter
End:
18,361,616 bp from pter
Size:
483,770 bases
Orientation:
Plus strand

Genomic View for KCNS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNS3 Gene

Regulatory Elements for KCNS3 Gene

Proteins for KCNS3 Gene

  • Protein details for KCNS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ31-KCNS3_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily S member 3
    Protein Accession:
    Q9BQ31
    Secondary Accessions:
    • D6W520
    • O43651
    • Q4ZFY1
    • Q96B56

    Protein attributes for KCNS3 Gene

    Size:
    491 amino acids
    Molecular mass:
    56001 Da
    Quaternary structure:
    • Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins (By similarity).

neXtProt entry for KCNS3 Gene

Proteomics data for KCNS3 Gene at MOPED

Post-translational modifications for KCNS3 Gene

No Post-translational modifications

Other Protein References for KCNS3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNS3 Gene

Domains for KCNS3 Gene

Gene Families for KCNS3 Gene

HGNC:
  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels
IUPHAR :

UniProtKB/Swiss-Prot:

KCNS3_HUMAN
Domain:
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position:
    • Q9BQ31
Family:
  • Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily.:
    • Q9BQ31
genes like me logo Genes that share domains with KCNS3: view

Function for KCNS3 Gene

Molecular function for KCNS3 Gene

UniProtKB/Swiss-Prot Function: Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity).

Gene Ontology (GO) - Molecular Function for KCNS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005249 voltage-gated potassium channel activity --
GO:0005251 delayed rectifier potassium channel activity IBA --
GO:0005515 protein binding --
GO:0015459 potassium channel regulator activity TAS 10484328
genes like me logo Genes that share ontologies with KCNS3: view

Phenotypes for KCNS3 Gene

GenomeRNAi human phenotypes for KCNS3:
genes like me logo Genes that share phenotypes with KCNS3: view

miRNA for KCNS3 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KCNS3 Gene

Localization for KCNS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNS3 Gene

Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNS3 Gene COMPARTMENTS Subcellular localization image for KCNS3 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for KCNS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with KCNS3: view

Pathways for KCNS3 Gene

genes like me logo Genes that share pathways with KCNS3: view

Gene Ontology (GO) - Biological Process for KCNS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006811 ion transport --
GO:0006813 potassium ion transport TAS 10484328
GO:0007268 synaptic transmission TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNS3: view

Compounds for KCNS3 Gene

(5) Tocris Compounds for KCNS3 Gene

Compound Action Cas Number
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
ICA 110381 KV7.2/7.3 activator; displays anticonvulsant properties [325457-99-6]
JNJ 303 Potent and selective IKs blocker [878489-28-2]
ShK-Dap22 Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro [220384-25-8]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]

(1) Novoseek inferred chemical compound relationships for KCNS3 Gene

Compound -log(P) Hits PubMed IDs
potassium 51.3 2
genes like me logo Genes that share compounds with KCNS3: view

Transcripts for KCNS3 Gene

Unigene Clusters for KCNS3 Gene

Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNS3 Gene

No ASD Table

Relevant External Links for KCNS3 Gene

GeneLoc Exon Structure for
KCNS3
ECgene alternative splicing isoforms for
KCNS3

Expression for KCNS3 Gene

mRNA expression in normal human tissues for KCNS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNS3 Gene

This gene is overexpressed in Muscle - Skeletal (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNS3 Gene

SOURCE GeneReport for Unigene cluster for KCNS3 Gene Hs.414489

mRNA Expression by UniProt/SwissProt for KCNS3 Gene

Q9BQ31-KCNS3_HUMAN
Tissue specificity: Detected in whole normal term placental and placental chorionic plate arteries and veins. Detected in syncytiotrophoblast and in blood vessel endothelium within intermediate villi and chorionic plate (at protein level). Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung.
genes like me logo Genes that share expressions with KCNS3: view

Orthologs for KCNS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNS3 36
  • 99.52 (n)
  • 99.8 (a)
KCNS3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNS3 36
  • 89.75 (n)
  • 95.7 (a)
KCNS3 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 70 (a)
OneToMany
KCNS3 36
  • 91.11 (n)
  • 96.74 (a)
KCNS3 37
  • 97 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Kcns3 36
  • 88.32 (n)
  • 94.91 (a)
Kcns3 16
Kcns3 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNS3 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNS3 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcns3 36
  • 88.05 (n)
  • 95.52 (a)
chicken
(Gallus gallus)
Aves KCNS3 36
  • 77.39 (n)
  • 85.51 (a)
KCNS3 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNS3 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcns3 36
  • 72.32 (n)
  • 79.5 (a)
zebrafish
(Danio rerio)
Actinopterygii KCNS3 (1 of 2) 37
  • 62 (a)
OneToMany
KCNS3 (2 of 2) 37
  • 51 (a)
OneToMany
zgc:194841 36
  • 63.95 (n)
  • 64.51 (a)
worm
(Caenorhabditis elegans)
Secernentea F44A2.2 38
  • 32 (a)
exp-2 38
  • 33 (a)
Y48A6B.6 38
  • 33 (a)
Species with no ortholog for KCNS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNS3 Gene

ENSEMBL:
Gene Tree for KCNS3 (if available)
TreeFam:
Gene Tree for KCNS3 (if available)

Paralogs for KCNS3 Gene

Paralogs for KCNS3 Gene

Selected SIMAP similar genes for KCNS3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCNS3: view

Variants for KCNS3 Gene

Sequence variations from dbSNP and Humsavar for KCNS3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs963886 -- 17,921,915(-) ATATA(C/T)ACACA intron-variant
rs971255 -- 17,912,468(-) TCCAT(A/G)CAACT intron-variant
rs1031769 -- 17,882,748(-) CCTTG(C/T)TATTA intron-variant
rs1031770 -- 17,876,348(-) CCTCC(C/T)GATAT upstream-variant-2KB
rs1031772 -- 17,933,286(-) TAGTA(C/T)AAAAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for KCNS3 Gene

Variant ID Type Subtype PubMed ID
dgv4062n71 CNV Gain 21882294
nsv518050 CNV Gain 19592680

Relevant External Links for KCNS3 Gene

HapMap Linkage Disequilibrium report
KCNS3
Human Gene Mutation Database (HGMD)
KCNS3

Disorders for KCNS3 Gene

Relevant External Links for KCNS3

Genetic Association Database (GAD)
KCNS3
Human Genome Epidemiology (HuGE) Navigator
KCNS3
genes like me logo Genes that share disorders with KCNS3: view

No data available for UniProtKB/Swiss-Prot for KCNS3 Gene

Publications for KCNS3 Gene

  1. A high-density association screen of 155 ion transport genes for involvement with common migraine. (PMID: 18676988) Nyholt D.R. … Palotie A. (Hum. Mol. Genet. 2008) 3 23 49
  2. Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness. (PMID: 15714333) Hao K. … Xu X. (Hum. Genet. 2005) 3 23 49
  3. Electrically silent potassium channel subunits from human lens epithelium. (PMID: 10484328) Shepard A.R. … Rae J.L. (Am. J. Physiol. 1999) 2 3 4
  4. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3
  5. Expression of an electrically silent voltage-gated potassium channel in the human placenta. (PMID: 22943705) Fyfe G.K. … Wareing M. (J Obstet Gynaecol 2012) 3 4

Products for KCNS3 Gene

Sources for KCNS3 Gene

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