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KCNS3 Gene

protein-coding   GIFtS: 59
GCID: GC02P018059

Potassium Voltage-Gated Channel, Delayed-Rectifier, Subfamily...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Voltage-Gated Channel, Delayed-Rectifier, Subfamily S, Member
31 2
     Potassium Voltage-Gated Channel Delayed-Rectifier Protein S32
Delayed-Rectifier K(+) Channel Alpha Subunit 32 3     Potassium Voltage-Gated Channel Subfamily S Member 32
Voltage-Gated Potassium Channel Subunit Kv9.32 3     Shab-Related Delayed-Rectifier K+ Channel Alpha Subunit 32
KV9.32 5     Voltage-Gated Potassium Channel Protein Kv9.32

External Ids:    HGNC: 63021   Entrez Gene: 37902   Ensembl: ENSG000001707457   OMIM: 6038885   UniProtKB: Q9BQ313   

Export aliases for KCNS3 gene to outside databases

Previous GC identifers: GC02P017945 GC02P018026 GC02P018044 GC02P017981 GC02P017834


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNS3 Gene:
Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in
both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting
membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2
types: those that are functional by themselves and those that are electrically silent but capable of modulating
the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself
but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related
subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium
channel family. Alternatively spliced transcript variants encoding the same protein have been found for this
gene. (provided by RefSeq, Sep 2013)

GeneCards Summary for KCNS3 Gene:
KCNS3 (potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3) is a protein-coding gene. Diseases associated with KCNS3 include fainting, and migraine. GO annotations related to this gene include delayed rectifier potassium channel activity and potassium channel regulator activity. An important paralog of this gene is KCNF1.

UniProtKB/Swiss-Prot: KCNS3_HUMAN, Q9BQ31
Function: Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity)

summary for KCNS3 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNS3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNS3 gene promoter:
         AhR   RFX1   Spz1   RREB-1   Egr-1   C/EBPalpha   GATA-2   Nkx6-1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNS3 promoter sequence
   Search Chromatin IP Primers for KCNS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24   Ensembl cytogenetic band:  2p24.2   HGNC cytogenetic band: 2p24

KCNS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNS3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P018059:  view genomic region     (about GC identifiers)

Start:
18,059,114 bp from pter      End:
18,542,882 bp from pter
Size:
483,769 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KCNS3_HUMAN, Q9BQ31 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily S member 3  
Size: 491 amino acids; 56001 Da
Subunit: Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel
proteins (By similarity)
Secondary accessions: D6W520 O43651 Q4ZFY1 Q96B56

Explore the universe of human proteins at neXtProt for KCNS3: NX_Q9BQ31

Explore proteomics data for KCNS3 at MOPED


See KCNS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001269357.1  NP_002243.3  

ENSEMBL proteins: 
 ENSP00000385968   ENSP00000305824   ENSP00000400098  
Reactome Protein details: Q9BQ31

KCNS3 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
KCN: Potassium channels
Kv: Voltage-gated ion channels / Potassium channels

IUPHAR Guide to PHARMACOLOGY protein family classification: Kv9.3
Voltage-gated potassium channels

Selected InterPro protein domains (see all 9):
 IPR005821 Ion_trans_dom
 IPR000210 BTB/POZ-like
 IPR011333 BTB/POZ_fold
 IPR027359 Channel_four-helix_dom
 IPR003971 K_chnl_volt-dep_Kv9

Graphical View of Domain Structure for InterPro Entry Q9BQ31

ProtoNet protein and cluster: Q9BQ31

3 Blocks protein domains:
IPB000210 BTB/POZ domain
IPB003091 Potassium channel signature
IPB003971 Kv9 potassium channel alpha subunit signature


UniProtKB/Swiss-Prot: KCNS3_HUMAN, Q9BQ31
Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
acids at every third position
Similarity: Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily


KCNS3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: KCNS3_HUMAN, Q9BQ31
Function: Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity)

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005216ion channel activity ----
GO:0005249voltage-gated potassium channel activity ----
GO:0005251delayed rectifier potassium channel activity TAS10484328
GO:0005515protein binding ----
GO:0015459potassium channel regulator activity TAS10484328
     
KCNS3 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for KCNS3:
 Decreased Wnt reporter activit  Increased cell death HMECs cel 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNS3
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCNS3
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCNS3

miRNA
Products:
    
miRTarBase miRNAs that target KCNS3:
hsa-mir-192-5p (MIRT026551), hsa-mir-125b-5p (MIRT005009), hsa-mir-215-5p (MIRT024380), hsa-mir-124-3p (MIRT022698)

Block miRNA regulation of human, mouse, rat KCNS3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate KCNS3 (see all 11):
hsa-miR-4324 hsa-miR-320a hsa-miR-125a-5p hsa-miR-4251 hsa-miR-320d hsa-miR-135b hsa-miR-320b hsa-miR-125b
SwitchGear 3'UTR luciferase reporter plasmidKCNS3 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat KCNS3

Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNS3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
KCNS3_HUMAN, Q9BQ31: Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but
remain in an intracellular compartment in the absence of KCNB1
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
golgi apparatus4
cytosol3

Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IDA--
GO:0005794Golgi apparatus IDA--
GO:0005886plasma membrane TAS--
GO:0008076voltage-gated potassium channel complex IEA--
GO:0016020membrane ----

KCNS3 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for KCNS3 About    
See pathways by source

SuperPathContained pathways About
1Integration of energy metabolism
Integration of energy metabolism0.75
Regulation of Insulin Secretion by Glucagon-like Peptide-10.56
Regulation of Insulin Secretion0.75
2Potassium Channels
Potassium Channels0.43
Voltage gated Potassium channels0.43
3Transmission across Chemical Synapses
Neuronal System0.68
4Metabolism
Metabolism0.38
5Dopamine-DARPP32 Feedback onto cAMP Pathway
Dopamine-DARPP32 Feedback onto cAMP Pathway

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KCNS3
    Dopamine-DARPP32 Feedback onto cAMP Pathway

2 Reactome Pathways for KCNS3
    Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Voltage gated Potassium channels



KCNS3 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNS3
Interactions:

    GeneGlobe Interaction Network for KCNS3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for KCNS3 (Q9BQ313 ENSP000003058244) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
InteractantInteraction Details
GeneCardExternal ID(s)
KCNB1Q147213, ENSP000003608064I2D: score=2 STRING: ENSP00000360806
KCNA10ENSP000003587864STRING: ENSP00000358786
KCNA2ENSP000003145204STRING: ENSP00000314520
KCNA3ENSP000003587844STRING: ENSP00000358784
KCNA5ENSP000002523214STRING: ENSP00000252321
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Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006112energy reserve metabolic process TAS--
GO:0006811ion transport ----
GO:0006813potassium ion transport TAS10484328
GO:0007268synaptic transmission TAS--
GO:0044281small molecule metabolic process TAS--

KCNS3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for KCNS3 available from Tocris Bioscience    About this table
CompoundAction CAS #
ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
JNJ 303Potent and selective IKs blocker[878489-28-2]
E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

1 Novoseek inferred chemical compound relationship for KCNS3 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
potassium 51.3 6 16914430 (1), 15714333 (1)



KCNS3 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for KCNS3 gene (2 alternative transcripts): 
NM_001282428.1  NM_002252.4  

Unigene Cluster for KCNS3:

Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
Hs.414489  [show with all ESTs]
Unigene Representative Sequence: AK225833
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000403915(uc002rcv.3) ENST00000481414 ENST00000304101(uc002rcw.3)
ENST00000465292 ENST00000419802
miRNA
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Block miRNA regulation of human, mouse, rat KCNS3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate KCNS3 (see all 11):
hsa-miR-4324 hsa-miR-320a hsa-miR-125a-5p hsa-miR-4251 hsa-miR-320d hsa-miR-135b hsa-miR-320b hsa-miR-125b
SwitchGear 3'UTR luciferase reporter plasmidKCNS3 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat KCNS3
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GenScript: all cDNA clones in your preferred vector: KCNS3 (NM_002252)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNS3
Primer
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OriGene qPCR primer pairs and template standards for KCNS3
OriGene qSTAR qPCR primer pairs in human, mouse for KCNS3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNS3
  QuantiTect SYBR Green Assays in human, mouse, rat KCNS3
  QuantiFast Probe-based Assays in human, mouse, rat KCNS3

Additional mRNA sequence: 

AF043472.1 AK075088.1 AK225833.1 AK314451.1 BC004148.2 BC004987.1 BC015947.2 

3 DOTS entries:

DT.409782  DT.95375254  DT.100700162 

Selected AceView cDNA sequences (see all 83):

BU538067 BU558183 BU527170 BU943876 AI521776 CA417717 CR615536 CF264718 
BE896067 BQ007800 BM799345 BM700454 NM_002252 BM761522 AW297836 CB995485 
BX349032 BG574180 CB243937 BI860475 BG478702 AA024791 BU597059 BG476037 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KCNS3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAAACTAGGA
KCNS3 Expression
About this image


KCNS3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
         Human embryonic stem cells (family)
KCNS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

KCNS3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.414489

UniProtKB/Swiss-Prot: KCNS3_HUMAN, Q9BQ31
Tissue specificity: Detected in whole normal term placental and placental chorionic plate arteries and veins.
Detected in syncytiotrophoblast and in blood vessel endothelium within intermediate villi and chorionic plate (at
protein level). Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of
expression are in lung

    Custom PCR Arrays for KCNS3
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNS3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for KCNS3 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Kcns31 , 5 potassium voltage-gated channel, delayed-rectifier, more1, 5 88.32(n)1
94.91(a)1
  12 (5.58 cM)5
2380761  NM_001168564.11  NP_001162036.11 
 110902025 
chicken
(Gallus gallus)
Aves KCNS31 potassium voltage-gated channel, delayed-rectifier, more 77.39(n)
85.51(a)
  428653  XM_426211.4  XP_426211.2 
lizard
(Anolis carolinensis)
Reptilia KCNS36
potassium voltage-gated channel, delayed-rectifier...
82(a)
1 ↔ 1
1(142896454-142940981)
tropical clawed frog
(Xenopus tropicalis)
Amphibia kcns31 potassium voltage-gated channel, delayed-rectifier, more 72.32(n)
79.5(a)
  100497261  XM_004918196.1  XP_004918253.1 
zebrafish
(Danio rerio)
Actinopterygii zgc:1948411 zgc:194841 63.95(n)
64.51(a)
  565375  NM_001128724.1  NP_001122196.1 


ENSEMBL Gene Tree for KCNS3 (if available)
TreeFam Gene Tree for KCNS3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for KCNS3 gene
KCNF12  KCNG32  KCNB22  KCNV12  KCNG22  KCNS22  KCNB12  KCNV22  
KCNG42  KCNG12  KCNS12  
Selected SIMAP similar genes for KCNS3 using alignment to 3 protein entries:     KCNS3_HUMAN (see all proteins) (see all similar genes):
KCNS2    KCNS1    KCNB2    KCNB1    KCNF1    KCNV2
KCNV1    KCNG1    KCNG4    KCNC2    KCND2    KCNG2
KCND1    KCND3    KCNG3    KCNC1    KCNA1    KCNA10

KCNS3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for KCNS3 (see all 1194)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1411682761,2
C--17835784(+) TCCTC-/TCTTTT 1 -- int10--------
rs779270101,2
C--17843525(+) CTTCCT/CCCAAG 1 -- int11Minor allele frequency- C:0.00NA 2
rs719503541,2
C--17855668(+) CAGTC-/ATCT  
        
ATCTA
1 -- int10--------
rs585218281,2
C--17855679(+) CTATC-/T/TATC
        
ATCTA
1 -- int10--------
rs339168471,2
C--17869367(+) TTAAT-/C/GTAAAC 1 -- int10--------
rs2016891671,2
--17884021(+) CTTTC-/TTAACCA 1 -- int10--------
rs768041421,2
C,F--18026269(+) TCCCAC/TTGTGT 1 -- us2k11Minor allele frequency- T:0.05NA 120
rs1812966101,2
--18026347(+) GCACTG/TCAGGT 1 -- us2k10--------
rs1160928741,2
--18026430(+) CTTAGA/TGATTT 1 -- us2k10--------
rs1836531021,2
--18026469(+) AGAGAA/TCTGGA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for KCNS3 (18059114 - 18309114 bp, first 250kb of KCNS3)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for KCNS3:    About this table    
Variant IDTypeSubtypePubMed ID
nsv518050CNV Gain19592680
dgv4062n71CNV Gain21882294

Human Gene Mutation Database (HGMD): KCNS3
Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603888    OMIM disorders: --

9 diseases for KCNS3:    
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fainting    migraine    amyotrophic lateral sclerosis    lateral sclerosis
hypoxia    bipolar disorder    cerebritis    neuronitis
endotheliitis


KCNS3 for disorders           About GeneDecksing

Genetic Association Database (GAD): KCNS3
Human Genome Epidemiology (HuGE) Navigator: KCNS3 (3 documents)

Export disorders for KCNS3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for KCNS3 gene, integrated from 10 sources (see all 36):
(articles sorted by number of sources associating them with KCNS3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Electrically silent potassium channel subunits from human lens epithelium. (PubMed id 10484328)1, 2, 3 Shepard A.R. and Rae J.L. (Am. J. Physiol. 1999)
  2. Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness. (PubMed id 15714333)1, 4, 9 Hao K....Xu X. (Hum. Genet. 2005)
  3. A high-density association screen of 155 ion transport genes for involvement with common migraine. (PubMed id 18676988)1, 4, 9 Nyholt D.R....Palotie A. (Hum. Mol. Genet. 2008)
  4. Expression of an electrically silent voltage-gated potassium channel in the human placenta. (PubMed id 22943705)1, 2 Fyfe G.K....Wareing M. (J Obstet Gynaecol 2012)
  5. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (Pharmacol. Rev. 2005)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Lower gene expression for KCNS3 potassium channel subunit in parvalbumin-containing neurons in the prefrontal cortex in schizophrenia. (PubMed id 24170294)1 Georgiev D....Hashimoto T. (Am J Psychiatry 2014)
  8. Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci. (PubMed id 22365631)4 Greenwood T.A....Kelsoe J.R. (Biol. Psychiatry 2012)
  9. Expression and function of K(V)2-containing channels in human urinary bladder smooth muscle. (PubMed id 22422395)1 Hristov K.L....Petkov G.V. (Am. J. Physiol., Cell Physiol. 2012)
  10. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3790 HGNC: 6302 AceView: KCNS3 Ensembl:ENSG00000170745 euGenes: HUgn3790
ECgene: KCNS3 H-InvDB: KCNS3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for KCNS3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for KCNS3 gene:
Search GeneIP for patents involving KCNS3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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