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Aliases for KCNS3 Gene

Aliases for KCNS3 Gene

  • Potassium Voltage-Gated Channel Modifier Subfamily S Member 3 2 3 5
  • Potassium Voltage-Gated Channel, Delayed-Rectifier, Subfamily S, Member 3 2 3
  • Delayed-Rectifier K(+) Channel Alpha Subunit 3 3 4
  • Voltage-Gated Potassium Channel Subunit Kv9.3 3 4
  • Potassium Voltage-Gated Channel, Modifier Subfamily S, Member 3 2
  • Potassium Voltage-Gated Channel Delayed-Rectifier Protein S3 3
  • Shab-Related Delayed-Rectifier K+ Channel Alpha Subunit 3 3
  • Potassium Voltage-Gated Channel Subfamily S Member 3 3
  • Voltage-Gated Potassium Channel Protein Kv9.3 3
  • KV9.3 3

External Ids for KCNS3 Gene

Previous GeneCards Identifiers for KCNS3 Gene

  • GC02P017945
  • GC02P018026
  • GC02P018044
  • GC02P017981
  • GC02P018059

Summaries for KCNS3 Gene

Entrez Gene Summary for KCNS3 Gene

  • Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for KCNS3 Gene

KCNS3 (Potassium Voltage-Gated Channel Modifier Subfamily S Member 3) is a Protein Coding gene. Among its related pathways are Metabolism and Potassium Channels. GO annotations related to this gene include ion channel activity and potassium channel regulator activity. An important paralog of this gene is KCNS2.

UniProtKB/Swiss-Prot for KCNS3 Gene

  • Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:10484328). Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity).

Tocris Summary for KCNS3 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNS3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNS3 Gene

Genomics for KCNS3 Gene

Regulatory Elements for KCNS3 Gene

Enhancers for KCNS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F017878 0.6 ENCODE 39.7 +1.5 1480 2.0 ZNF2 ETS1 GLIS2 ZNF366 SCRT2 EGR2 ZNF263 ZNF680 SP3 SP5 KCNS3 GC02P017933
GH02F017892 0.7 Ensembl ENCODE 29 +15.3 15320 0.9 KLF1 MAFG ZNF407 ZNF316 FOS NFE2 EMSY MAFK KCNS3 ENSG00000260331 GC02P017933
GH02F017912 0.4 Ensembl 21.4 +34.7 34654 0.2 IKZF1 SPI1 KCNS3 GC02P017933
GH02F017934 0.8 Ensembl ENCODE 10.8 +57.0 57039 1.3 FOS MAFK NR2F2 KCNS3 ENSG00000260331 GC02P017933 GC02M017915
GH02F018076 1 ENCODE 7.3 +199.8 199790 1.5 KCNS3 GC02P018107 ENSG00000212455 GC02M018040
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KCNS3 on UCSC Golden Path with GeneCards custom track

Promoters for KCNS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001539942 1153 2400 RAD21 ZNF2 ETS1 GLIS2 ZNF366 SCRT2 EGR2 ZNF263 ZNF680 SP3

Genomic Location for KCNS3 Gene

Chromosome:
2
Start:
17,877,847 bp from pter
End:
18,361,616 bp from pter
Size:
483,770 bases
Orientation:
Plus strand

Genomic View for KCNS3 Gene

Genes around KCNS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNS3 Gene

Proteins for KCNS3 Gene

  • Protein details for KCNS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ31-KCNS3_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily S member 3
    Protein Accession:
    Q9BQ31
    Secondary Accessions:
    • D6W520
    • O43651
    • Q4ZFY1
    • Q96B56

    Protein attributes for KCNS3 Gene

    Size:
    491 amino acids
    Molecular mass:
    56001 Da
    Quaternary structure:
    • Heterotetramer with KCNB1 (PubMed:10484328). Does not form homomultimers (PubMed:10484328).

neXtProt entry for KCNS3 Gene

Post-translational modifications for KCNS3 Gene

No Post-translational modifications

Other Protein References for KCNS3 Gene

No data available for DME Specific Peptides for KCNS3 Gene

Domains & Families for KCNS3 Gene

Gene Families for KCNS3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BQ31

UniProtKB/Swiss-Prot:

KCNS3_HUMAN :
  • The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
  • Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily.
Domain:
  • The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
Family:
  • Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily.
genes like me logo Genes that share domains with KCNS3: view

Function for KCNS3 Gene

Molecular function for KCNS3 Gene

UniProtKB/Swiss-Prot Function:
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:10484328). Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity).

Gene Ontology (GO) - Molecular Function for KCNS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005249 voltage-gated potassium channel activity IEA --
GO:0005251 delayed rectifier potassium channel activity TAS 10484328
GO:0005267 potassium channel activity IEA --
GO:0015459 potassium channel regulator activity TAS 10484328
genes like me logo Genes that share ontologies with KCNS3: view
genes like me logo Genes that share phenotypes with KCNS3: view

Animal Model Products

miRNA for KCNS3 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNS3 Gene

Localization for KCNS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNS3 Gene

Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 (PubMed:10484328). {ECO:0000269 PubMed:10484328}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNS3 Gene COMPARTMENTS Subcellular localization image for KCNS3 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for KCNS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with KCNS3: view

Pathways & Interactions for KCNS3 Gene

genes like me logo Genes that share pathways with KCNS3: view

Gene Ontology (GO) - Biological Process for KCNS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA,TAS 10484328
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0050796 regulation of insulin secretion TAS --
genes like me logo Genes that share ontologies with KCNS3: view

No data available for SIGNOR curated interactions for KCNS3 Gene

Drugs & Compounds for KCNS3 Gene

(5) Drugs for KCNS3 Gene - From: Tocris and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4-Aminopyridine Approved Pharma Pore Blocker potassium channel-blocking agent, Non-selective KV channel blocker 68
E-4031 dihydrochloride Pharma KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) 0
Linopirdine dihydrochloride Pharma KV7 (KCNQ) channel blocker 0
XE 991 dihydrochloride Pharma Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents 0

(1) Additional Compounds for KCNS3 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
HMR 1556
223749-46-0

(5) Tocris Compounds for KCNS3 Gene

Compound Action Cas Number
4-Aminopyridine Non-selective KV channel blocker 504-24-5
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) 113559-13-0
HMR 1556 Potent and selective Iks channel blocker 223749-46-0
Linopirdine dihydrochloride KV7 (KCNQ) channel blocker 113168-57-3
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents 122955-13-9
genes like me logo Genes that share compounds with KCNS3: view

Transcripts for KCNS3 Gene

Unigene Clusters for KCNS3 Gene

Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNS3 Gene

No ASD Table

Relevant External Links for KCNS3 Gene

GeneLoc Exon Structure for
KCNS3
ECgene alternative splicing isoforms for
KCNS3

Expression for KCNS3 Gene

mRNA expression in normal human tissues for KCNS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNS3 Gene

This gene is overexpressed in Muscle - Skeletal (x5.6).

Protein differential expression in normal tissues from HIPED for KCNS3 Gene

This gene is overexpressed in Gallbladder (44.6) and Plasma (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNS3 Gene



Protein tissue co-expression partners for KCNS3 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCNS3 Gene:

KCNS3

SOURCE GeneReport for Unigene cluster for KCNS3 Gene:

Hs.414489

mRNA Expression by UniProt/SwissProt for KCNS3 Gene:

Q9BQ31-KCNS3_HUMAN
Tissue specificity: Detected in whole normal term placental and placental chorionic plate arteries and veins. Detected in syncytiotrophoblast and in blood vessel endothelium within intermediate villi and chorionic plate (at protein level) (PubMed:22943705). Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung (PubMed:10484328).
genes like me logo Genes that share expression patterns with KCNS3: view

Primer Products

Orthologs for KCNS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNS3 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia KCNS3 34 35
  • 91.11 (n)
-- 35
  • 70 (a)
OneToMany
cow
(Bos Taurus)
Mammalia KCNS3 34 35
  • 89.75 (n)
mouse
(Mus musculus)
Mammalia Kcns3 34 16 35
  • 88.32 (n)
rat
(Rattus norvegicus)
Mammalia Kcns3 34
  • 88.05 (n)
oppossum
(Monodelphis domestica)
Mammalia KCNS3 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNS3 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNS3 34 35
  • 77.39 (n)
lizard
(Anolis carolinensis)
Reptilia KCNS3 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcns3 34
  • 72.32 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:194841 34
  • 63.95 (n)
KCNS3 (1 of 2) 35
  • 62 (a)
OneToMany
KCNS3 (2 of 2) 35
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea exp-2 36
  • 33 (a)
Y48A6B.6 36
  • 33 (a)
F44A2.2 36
  • 32 (a)
Species where no ortholog for KCNS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNS3 Gene

ENSEMBL:
Gene Tree for KCNS3 (if available)
TreeFam:
Gene Tree for KCNS3 (if available)

Paralogs for KCNS3 Gene

Paralogs for KCNS3 Gene

genes like me logo Genes that share paralogs with KCNS3: view

Variants for KCNS3 Gene

Sequence variations from dbSNP and Humsavar for KCNS3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10153737 -- 17,919,522(+) TTTTG(C/T)TAGTT intron-variant
rs10153939 -- 17,919,411(+) AGGTG(A/G)GTTTA intron-variant
rs10166165 -- 17,928,233(+) tttgc(C/T)aattt intron-variant
rs10166838 -- 17,907,765(+) ttttc(C/T)ttaag intron-variant
rs10168055 -- 17,894,146(+) ATGTG(A/G)GCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNS3 Gene

Variant ID Type Subtype PubMed ID
esv3589949 CNV gain 21293372
esv3891603 CNV gain 25118596
nsv1007774 CNV gain 25217958
nsv1126541 CNV deletion 24896259
nsv518050 CNV gain 19592680
nsv997502 CNV gain 25217958

Variation tolerance for KCNS3 Gene

Residual Variation Intolerance Score: 46.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNS3 Gene

Human Gene Mutation Database (HGMD)
KCNS3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNS3 Gene

Disorders for KCNS3 Gene

Relevant External Links for KCNS3

Genetic Association Database (GAD)
KCNS3
Human Genome Epidemiology (HuGE) Navigator
KCNS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNS3

No disorders were found for KCNS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNS3 Gene

Publications for KCNS3 Gene

  1. A high-density association screen of 155 ion transport genes for involvement with common migraine. (PMID: 18676988) Nyholt D.R. … Palotie A. (Hum. Mol. Genet. 2008) 3 22 46 64
  2. Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness. (PMID: 15714333) Hao K. … Xu X. (Hum. Genet. 2005) 3 22 46 64
  3. Electrically silent potassium channel subunits from human lens epithelium. (PMID: 10484328) Shepard A.R. … Rae J.L. (Am. J. Physiol. 1999) 2 3 4 64
  4. Expression of an electrically silent voltage-gated potassium channel in the human placenta. (PMID: 22943705) Fyfe G.K. … Wareing M. (J Obstet Gynaecol 2012) 3 4 64
  5. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3 64

Products for KCNS3 Gene

Sources for KCNS3 Gene

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