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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KCNS3 Gene

protein-coding GIFtS: 57
GCID: GC02P018059

potassium voltage-gated channel, delayed-rectifier, subfamily...

Explore 6 diseases affiliated with
KCNS3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Potassium Voltage-Gated Channel, Delayed-Rectifier, Subfamily S, Member 3¹ ²		Potassium Voltage-Gated Channel Delayed-Rectifier Protein S3²
Delayed-Rectifier K(+) Channel Alpha Subunit 3² ³		Potassium Voltage-Gated Channel Subfamily S Member 3²
Voltage-Gated Potassium Channel Subunit Kv9.3² ³		Shab-Related Delayed-Rectifier K+ Channel Alpha Subunit 3²
KV9.3² ⁵		Voltage-Gated Potassium Channel Protein Kv9.3²
Kv9.3¹

External Ids:	HGNC: 6302¹	Entrez Gene: 3790²	Ensembl: ENSG00000170745⁷	OMIM: 603888⁵	UniProtKB: Q9BQ31³

Export aliases for KCNS3 gene to outside databases

Previous GC identifers: GC02P017945 GC02P018026 GC02P018044 GC02P017981 GC02P017834

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNS3:

Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both

excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane

potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those

that are functional by themselves and those that are electrically silent but capable of modulating the activity of

specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form

heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of

potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCNS3_HUMAN, Q9BQ31

Function: Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity)

summary for KCNS3:

Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the

Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits

contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed

within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNS3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_015926.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KCNS3 gene promoter:
AhR RFX1 Spz1 RREB-1 Egr-1 C/EBPalpha GATA-2 Nkx6-1 FOXJ2 (long isoform) FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNS3 promoter sequence

Search SABiosciences Chromatin IP Primers for KCNS3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNS3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24 Ensembl cytogenetic band: 2p24.2 HGNC cytogenetic band: 2p24

KCNS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNS3 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P018059: view genomic region (about GC identifiers)

Start:	18,059,114 bp from pter	End:	18,542,882 bp from pter
Size:	483,769 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KCNS3_HUMAN, Q9BQ31 (See protein sequence)

Recommended Name: Potassium voltage-gated channel subfamily S member 3

Size: 491 amino acids; 56001 Da

Subunit: Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel

proteins (By similarity)

Subcellular location: Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in

an intracellular compartment in the absence of KCNB1

Secondary accessions: D6W520 O43651 Q4ZFY1 Q96B56

Explore the universe of human proteins at neXtProt for KCNS3: NX_Q9BQ31

KCNS3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002243.3

ENSEMBL proteins:

ENSP00000385968 ENSP00000305824 ENSP00000400098

Reactome Protein details: Q9BQ31
Human Recombinant Protein Products for KCNS3:

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	Uscn Proteins for KCNS3

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005794	Golgi apparatus	IDA	--
GO:0005886	plasma membrane	TAS	--
GO:0008076	voltage-gated potassium channel complex	IEA	--
GO:0043231	intracellular membrane-bounded organelle	IDA	--

KCNS3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for KCNS3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KCNS3 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR005821 Ion_trans_dom

IPR000210 BTB/POZ-like

IPR011333 BTB/POZ_fold

IPR003971 K_chnl_volt-dep_Kv9

IPR003968 K_chnl_volt-dep_Kv

Graphical View of Domain Structure for InterPro Entry Q9BQ31

ProtoNet protein and cluster: Q9BQ31

3 Blocks protein families:

IPB000210 BTB/POZ domain

IPB003091 Potassium channel signature

IPB003971 Kv9 potassium channel alpha subunit signature

UniProtKB/Swiss-Prot: KCNS3_HUMAN, Q9BQ31

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino

acids at every third position

Similarity: Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: KCNS3_HUMAN, Q9BQ31

Function: Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005249	voltage-gated potassium channel activity	--	--
GO:0005251	delayed rectifier potassium channel activity	TAS	10484328
GO:0015459	potassium channel regulator activity	TAS	10484328

KCNS3 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for KCNS3:

Decreased Wnt reporter activit

Increased cell death HMECs cel

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for KCNS3

miRNA Products:		miRTarBase miRNAs that target KCNS3: hsa-mir-125b (MIRT005009)

		OriGene 3'-UTR Clone: KCNS3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNS3
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNS3 (see all 11):
		hsa-miR-4324 hsa-miR-320a hsa-miR-125a-5p hsa-miR-4251 hsa-miR-320d hsa-miR-135b hsa-miR-320b hsa-miR-125b

		SwitchGear 3'UTR luciferase reporter plasmid: KCNS3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNS3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNS3 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNS3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Regulation of Insulin Secretion

	Regulation of Insulin Secretion	1.00			Regulation of Insulin Secretion by Glucagon-like Peptide-1	0.55
	Integration of energy metabolism	0.74

Potassium Channels

Potassium Channels

1.00

Voltage gated Potassium channels

0.43

Metabolism

Metabolism

1.00

Dopamine-DARPP32 Feedback onto cAMP Pathway

Dopamine-DARPP32 Feedback onto cAMP Pathway

1.00

Closing of Potassium voltage-gated channels by PKA

Closing of Potassium voltage-gated channels by PKA

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNS3

Dopamine-DARPP32 Feedback onto cAMP Pathway

5/8 Reactome Pathways for KCNS3 (see all 8)

	Potassium Channels
	Regulation of Insulin Secretion by Glucagon-like Peptide-1
	Closing of Potassium voltage-gated channels by PKA
	Metabolism
	Regulation of Insulin Secretion

KCNS3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KCNS3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/48 Interacting proteins for KCNS3 (Q9BQ31³ ENSP00000305824⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 48)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KCNB1	Q14721³, ENSP00000360806⁴	I2D: score=2 STRING: ENSP00000360806
KCNA10	ENSP00000358786⁴	STRING: ENSP00000358786
KCNA2	ENSP00000314520⁴	STRING: ENSP00000314520
KCNA3	ENSP00000358784⁴	STRING: ENSP00000358784
KCNA5	ENSP00000252321⁴	STRING: ENSP00000252321

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006112	energy reserve metabolic process	TAS	--
GO:0006813	potassium ion transport	TAS	10484328
GO:0007268	synaptic transmission	TAS	--
GO:0044281	small molecule metabolic process	TAS	--
GO:0050796	regulation of insulin secretion	TAS	--

KCNS3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KCNS3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for KCNS3 available from Tocris Bioscience About this table

Compound	Action	CAS #
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
4-Aminopyridine	Non-selective KV channel blocker	[504-24-5]

1 Novoseek chemical compound relationship for KCNS3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	51.3	6	16914430 (1), 15714333 (1)

Search CenterWatch for drugs/clinical trials and news about KCNS3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KCNS3 gene:

NM_002252.3

Unigene Cluster for KCNS3:

Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3

Hs.414489 [show with all ESTs]

Unigene Representative Sequence: AK225833

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000403915(uc002rcv.3) ENST00000481414 ENST00000304101(uc002rcw.3)

ENST00000465292 ENST00000419802

miRNA Products:		OriGene 3'-UTR Clone: KCNS3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNS3
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNS3 (see all 11):
		hsa-miR-4324 hsa-miR-320a hsa-miR-125a-5p hsa-miR-4251 hsa-miR-320d hsa-miR-135b hsa-miR-320b hsa-miR-125b

		SwitchGear 3'UTR luciferase reporter plasmid: KCNS3 3' UTR sequence

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Additional cDNA sequence:

AF043472.1 AK075088.1 AK225833.1 AK314451.1 BC004148.2 BC004987.1 BC015947.2

3 DOTS entries:

DT.409782 DT.95375254 DT.100700162

24/83 AceView cDNA sequences (see all 83):

BU527170 BM761522 BU538067 BU943876 BM700454 BU558183 CR615536 AW297836

NM_002252 CA417717 BE896067 CF264718 AI521776 BQ007800 BM799345 BG478702

BF593242 BC004987 AA024835 BU527741 BI769999 AW732573 BC015947 BU676043

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCNS3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAACTAGGA

About this image

KCNS3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KCNS3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNS3

SOURCE GeneReport for Unigene cluster: Hs.414489

UniProtKB/Swiss-Prot: KCNS3_HUMAN, Q9BQ31

Tissue specificity: Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression

are in lung

SABiosciences Custom PCR Arrays for KCNS3

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KCNS3 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KCNS3¹	potassium voltage-gated channel, delayed-rectifier, more	77.39(n) 85.51(a)		428653 XM_426211.3 XP_426211.2
lizard (Anolis carolinensis)	Reptilia	KCNS3⁶	--	83(a)	1 ↔ 1	1(142932831-142934315)
zebrafish (Danio rerio)	Actinopterygii	LOC565375¹	similar to potassium voltage-gated channel, delayed-rectifier, more	64.02(n) 64.64(a)		565375 NM_001128724.1 NP_001122196.1
honey bee (Apis mellifera)	Insecta	--	--	28(a)	possible ortholog	Group13.15(957-3745)
worm (Caenorhabditis elegans)	Secernentea	exp-2³	potassium channel protein	33(a) (best of 3)		V(6143964-6146014) --

ENSEMBL Gene Tree for KCNS3 (if available)
TreeFam Gene Tree for KCNS3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KCNS3 gene

KCNG3² KCNF1² KCNB2² KCNV1² KCNG2² KCNS2² KCNB1² KCNV2²

KCNG4² KCNG1² KCNS1²

18/25 SIMAP similar genes for KCNS3 using alignment to 3 protein entries: KCNS3_HUMAN (see all proteins) (see all similar genes):

KCNS2 KCNS1 KCNB2 KCNB1 KCNF1 KCNV2

KCNV1 KCNG1 KCNG4 KCNC2 KCND2 KCNG2

KCND1 KCND3 KCNG3 KCNC1 KCNA1 KCNA10

KCNS3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76804142^1,2	C,F	--	17833042(+)	`TCCCAC/TTGTGT`	1	--	us2k¹		1		NA	120
rs111477293^1,2		--	17833941(+)	`ACTGGG/ACGCCT`	1	--	us2k¹		1		CSA	2
rs115212754^1,2	C,F	--	17834082(+)	`GAGCGC/TTCTCG`	1	--	us2k¹		1		NA	120
rs16981871^1,2		--	17834775(+)	`GCTGCT/GGGCCC`	1	--	us2k¹		1		NA	2
rs10182515^1,2	C	--	17834889(+)	`CGCTCC/TAGCGG`	1	--	us2k¹		2		NA	4
rs199921008^1,2	C	--	17836137(-)	`CACCTA/CCCGCC`	1	--	int¹		0	--	--	--	--
rs35349881^1,2	C,F	--	17836183(+)	`TGGCCC/AGGAGC`	1	--	int¹		9		NA WA CSA	251
rs6731166^1,2	C,F	--	17836378(+)	`TGCCCA/GGGTAA`	1	--	int¹		1		WA	118
rs56327406^1,2	C,F	--	17837619(+)	`TGTGGG/AGACCC`	1	--	int¹		6		NA WA	246
rs77069239^1,2	F	--	17837907(+)	`AAGCTA/GGGATT`	1	--	int¹		1		NA	120

HapMap Linkage Disequilibrium report for KCNS3 (18059114 - 18309114 bp, first 250kb of KCNS3)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KCNS3: --
Human Gene Mutation Database (HGMD): KCNS3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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KCNS3 for disorders           About GeneDecksing

OMIM gene information: 603888    OMIM disorders: --

6 diseases for KCNS3:    About MalaCards

migraine fainting pharyngitis cerebritis

hypoxia neuronitis

Genetic Association Database (GAD): KCNS3
Human Genome Epidemiology (HuGE) Navigator: KCNS3 (3 documents)

Export disorders for KCNS3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KCNS3 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with KCNS3)

Utopia: connect your pdf to the dynamic
world of online information

Electrically silent potassium channel subunits from human lens epithelium. (PubMed id 10484328)^{1, 2, 3} Shepard A.R. and Rae J.L. (1999)
Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness. (PubMed id 15714333)^{1, 4, 9} Hao K....Xu X. (2005)
International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)^{1, 3} Gutman G.A....Wang X. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A high-density association screen of 155 ion transport genes for involvement with common migraine. (PubMed id 18676988)^{1, 9} Nyholt D.R....Palotie A. (2008)
Expression of an electrically silent voltage-gated pot assium channel in the human placenta. (PubMed id 22943705)¹ Fyfe G.K....Wareing M. (2012)
Expression and function of K(V)2-containing channels i n human urinary bladder smooth muscle. (PubMed id 22422395)¹ Hristov K.L....Petkov G.V. (2012)
Stromatoxin-sensitive, heteromultimeric Kv2.1/Kv9.3 c hannels contribute to myogenic control of cerebral arterial diameter. (PubMed id 20876197)¹ Zhong X.Z....Cole W.C. (2010)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
Fluorescence measurements reveal stoichiometry of K+ channels formed by modulatory and delayed rectifier alpha-subunits. (PubMed id 15827117)¹ Kerschensteiner D....Stocker M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3790	HGNC: 6302	AceView: KCNS3	Ensembl:ENSG00000170745	euGenes: HUgn3790
ECgene: KCNS3	H-InvDB: KCNS3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KCNS3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KCNS3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KCNS3 gene:
Search GeneIP for patents involving KCNS3

GeneCards and IP:
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