Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KCNS2 Gene

protein-coding   GIFtS: 54
GCID: GC08P099439

Potassium Voltage-Gated Channel, Delayed-Rectifier, Subfamily...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Potassium Voltage-Gated Channel, Delayed-Rectifier, Subfamily S, Member
21 2
Delayed-Rectifier K(+) Channel Alpha Subunit 22 3
Voltage-Gated Potassium Channel Subunit Kv9.22 3
KV9.22
Potassium Voltage-Gated Channel Subfamily S Member 22
KIAA11443

External Ids:    HGNC: 63011   Entrez Gene: 37882   Ensembl: ENSG000001564867   OMIM: 6029065   UniProtKB: Q9ULS63   

Export aliases for KCNS2 gene to outside databases

Previous GC identifers: GC08P098448 GC08P099513 GC08P099108 GC08P099387 GC08P099395 GC08P099508 GC08P094643


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for KCNS2 Gene:
KCNS2 (potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2) is a protein-coding gene. Diseases associated with KCNS2 include fainting, and neuronitis. GO annotations related to this gene include delayed rectifier potassium channel activity. An important paralog of this gene is KCNF1.

UniProtKB/Swiss-Prot: KCNS2_HUMAN, Q9ULS6
Function: Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity)

summary for KCNS2 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNS2 gene promoter:
         Sp1   Pax-5   STAT5A   LCR-F1   AP-2gamma   CREB   SRY   FAC1   deltaCREB   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNS2 promoter sequence
   Search Chromatin IP Primers for KCNS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22   Ensembl cytogenetic band:  8q22.2   HGNC cytogenetic band: 8q22

KCNS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNS2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P099439:  view genomic region     (about GC identifiers)

Start:
99,439,250 bp from pter      End:
99,445,076 bp from pter
Size:
5,827 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KCNS2_HUMAN, Q9ULS6 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily S member 2  
Size: 477 amino acids; 54237 Da
Subunit: Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel
proteins (By similarity)
Sequence caution: Sequence=BAA86458.1; Type=Erroneous initiation;
Secondary accessions: A8KAN1

Explore the universe of human proteins at neXtProt for KCNS2: NX_Q9ULS6

Explore proteomics data for KCNS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KCNS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065748.1  
    ENSEMBL proteins: 
     ENSP00000287042   ENSP00000430712  
    Reactome Protein details: Q9ULS6

    KCNS2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KCNS2
    GenScript Custom Purified and Recombinant Proteins Services for KCNS2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KCNS2

    KCNS2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for KCNS2
    OriGene Custom Antibody Services for KCNS2
    Novus Biologicals KCNS2 Antibodies
    Abcam antibodies for KCNS2
    Cloud-Clone Corp. Antibodies for KCNS2
    ThermoFisher Antibodies for KCNS2
    LSBio Antibodies in human, mouse, rat for KCNS2

    KCNS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KCNS2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KCNS2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KCNS2
    Cloud-Clone Corp. CLIAs for KCNS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    KCN: Potassium channels
    Kv: Voltage-gated ion channels / Potassium channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kv9.2
    Voltage-gated potassium channels

    Selected InterPro protein domains (see all 9):
     IPR005821 Ion_trans_dom
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR027359 Channel_four-helix_dom
     IPR003971 K_chnl_volt-dep_Kv9

    Graphical View of Domain Structure for InterPro Entry Q9ULS6

    ProtoNet protein and cluster: Q9ULS6

    3 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB003091 Potassium channel signature
    IPB003971 Kv9 potassium channel alpha subunit signature


    UniProtKB/Swiss-Prot: KCNS2_HUMAN, Q9ULS6
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.2/KCNS2 sub-subfamily


    KCNS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNS2_HUMAN, Q9ULS6
    Function: Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity)

         Genatlas biochemistry entry for KCNS2:
    potassium voltage-gated channel delayed-rectifier,subfamily Shab,member 1,highly and selectively expressed in the
    brain,modulator of Kv2.1,Kv2.2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005251delayed rectifier potassium channel activity IBA--
    GO:0005515protein binding ----
         
    KCNS2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KCNS2:
     Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Kcns2):
     normal 

    KCNS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Kcns2tm1Lex for KCNS2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KCNS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCNS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCNS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target KCNS2:
    hsa-mir-16-5p (MIRT051192)

    Block miRNA regulation of human, mouse, rat KCNS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCNS2 (see all 15):
    hsa-miR-548p hsa-miR-362-3p hsa-let-7a-2* hsa-miR-1179 hsa-miR-329 hsa-miR-4314 hsa-miR-19b hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidKCNS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KCNS2
    Predesigned siRNA for gene silencing in human, mouse, rat KCNS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KCNS2

    Clone
    Products:
         
    OriGene clones in human, mouse for KCNS2 (see all 6)
    OriGene ORF clones in mouse, rat for KCNS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCNS2 (NM_020697)
    Sino Biological Human cDNA Clone for KCNS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNS2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KCNS2
    Browse ESI BIO Cell Lines and PureStem Progenitors for KCNS2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KCNS2_HUMAN, Q9ULS6: Cell membrane; Multi-pass membrane protein (By similarity). Note=May not reach the plasma
    membrane but remain in an intracellular compartment in the absence of KCNB1 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IEA--
    GO:0016020membrane ----

    KCNS2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for KCNS2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Voltage gated Potassium channels0.43
    2Transmission across Chemical Synapses
    Neuronal System0.68
    3Dopamine-DARPP32 Feedback onto cAMP Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KCNS2
        Dopamine-DARPP32 Feedback onto cAMP Pathway


    1 Reactome Pathway for KCNS2
        Voltage gated Potassium channels



    KCNS2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNS2
    Interactions:

        Search GeneGlobe Interaction Network for KCNS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KCNS2 (ENSP000002870424) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNA10ENSP000003587864STRING: ENSP00000358786
    KCNA2ENSP000003145204STRING: ENSP00000314520
    KCNA3ENSP000003587844STRING: ENSP00000358784
    KCNA6ENSP000002806844STRING: ENSP00000280684
    KCNA7ENSP000002214444STRING: ENSP00000221444
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0007268synaptic transmission TAS--
    GO:0051260protein homooligomerization IEA--
    GO:0055085transmembrane transport ----

    KCNS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNS2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KCNS2 gene: 
    NM_020697.2  

    Unigene Cluster for KCNS2:

    Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2
    Hs.388045  [show with all ESTs]
    Unigene Representative Sequence: AB032970
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000287042(uc003yin.3) ENST00000521839
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KCNS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCNS2 (see all 15):
    hsa-miR-548p hsa-miR-362-3p hsa-let-7a-2* hsa-miR-1179 hsa-miR-329 hsa-miR-4314 hsa-miR-19b hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidKCNS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KCNS2
    Predesigned siRNA for gene silencing in human, mouse, rat KCNS2
    Clone
    Products:
         
    OriGene clones in human, mouse for KCNS2 (see all 6)
    OriGene ORF clones in mouse, rat for KCNS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCNS2 (NM_020697)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNS2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KCNS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNS2
      QuantiTect SYBR Green Assays in human, mouse, rat KCNS2
      QuantiFast Probe-based Assays in human, mouse, rat KCNS2

    Additional mRNA sequence: 

    AB032970.1 AK293096.1 BC027932.1 BC034778.1 

    1 DOTS entry:

    DT.442900 

    20 AceView cDNA sequences:

    NM_020697 BC034778 AB032970 Z40322 Z44391 H19264 BQ109445 R34920 
    U69192 BC027932 CF593395 AI681499 BI757430 R16167 BQ188030 R19352 
    BI819243 R15427 H19265 R44628 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KCNS2 expression in normal human tissues (normalized intensities)      KCNS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTTCACCT
    KCNS2 Expression
    About this image


    KCNS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Brain (Nervous System)
    KCNS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.388045
        Custom PCR Arrays for KCNS2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KCNS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNS2
    QuantiTect SYBR Green Assays in human, mouse, rat KCNS2
    QuantiFast Probe-based Assays in human, mouse, rat KCNS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for KCNS2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcns21 , 5 K+ voltage-gated channel, subfamily S, 21, 5 90.34(n)1
    98.32(a)1
      15 (14.34 cM)5
    165391  NM_001271704.11  NP_001258633.11 
     348373815 
    chicken
    (Gallus gallus)
    Aves KCNS21 potassium voltage-gated channel, delayed-rectifier, more 78.55(n)
    90.57(a)
      430463  XM_004939974.1  XP_004940031.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNS26
    potassium voltage-gated channel, delayed-rectifier...
    87(a)
    1 ↔ 1
    4(20882192-20883625)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kcns21 potassium voltage-gated channel, delayed-rectifier, more 73.86(n)
    83.23(a)
      101732753  XM_004915133.1  XP_004915190.1 


    ENSEMBL Gene Tree for KCNS2 (if available)
    TreeFam Gene Tree for KCNS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KCNS2 gene
    KCNF12  KCNG32  KCNB22  KCNV12  KCNG22  KCNS32  KCNB12  KCNV22  
    KCNG42  KCNG12  KCNS12  
    Selected SIMAP similar genes for KCNS2 using alignment to 1 protein entry:     KCNS2_HUMAN(see all similar genes):
    KCNS3    KCNS1    KCNB1    KCNB2    KCNF1    KCNG4
    KCNG1    KCNV1    KCNV2    KCNG2    KCNG3    KCNA1
    KCNA10    KCND3    KCNA2    KCNA7    KCNA3    KCNC1

    KCNS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KCNS2 (see all 107)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs671845551,2
    F--99437578(+) ACACAC/AACAAA 1 -- us2k12Minor allele frequency- A:0.50CSA 4
    rs1875902151,2
    --99724303(+) GCAAGG/TGTGGC 1 -- us2k10--------
    rs1122371051,2
    C,F--99724380(+) GTGGGG/AGCCAC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1907745011,2
    --99724476(+) ATAACA/CAAGAT 1 -- us2k10--------
    rs732739531,2
    C,F--99724491(+) TTTTTC/TTCCGT 1 -- us2k12Minor allele frequency- T:0.05WA 120
    rs1830148001,2
    --99724495(+) TCTCCA/GTCTCT 1 -- us2k10--------
    rs1381139051,2
    --99724664(+) AGGAAA/GTGTGT 1 -- us2k10--------
    rs746647231,2
    --99724948(+) TGGGAC/TGGCAT 1 -- us2k10--------
    rs1877926971,2
    --99724950(+) GGACGG/TCATTG 1 -- us2k10--------
    rs1917653781,2
    --99725069(+) GTAGAC/TGCTAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNS2 (99439250 - 99445076 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for KCNS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831406CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNS2
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602906    OMIM disorders: --

    2 diseases for KCNS2:    About MalaCards
    fainting    neuronitis


    KCNS2 for disorders           About GeneDecksing


    Export disorders for KCNS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KCNS2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KCNS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (Pharmacol. Rev. 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (DNA Res. 1999)
    4. New modulatory alpha subunits for mammalian Shab K+ channels. (PubMed id 9305895)1, 3 Salinas M....Lazdunski M. (J. Biol. Chem. 1997)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Identification and mapping of human cDNAs homologous to Drosophila mutant genes through EST database searching. (PubMed id 8640222)1 Banfi S....Ballabio A. (Nat. Genet. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3788 HGNC: 6301 AceView: KCNS2 Ensembl:ENSG00000156486 euGenes: HUgn3788
    ECgene: KCNS2 H-InvDB: KCNS2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1144

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KCNS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KCNS2 gene:
    Search GeneIP for patents involving KCNS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for KCNS2   OriGene RNAi products in human, mouse, rat for KCNS2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KCNS2  
     OriGene qSTAR qPCR primer pairs in human, mouse for KCNS2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KCNS2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KCNS2   OriGene Custom Protein Services for KCNS2  

     
     
     Block miRNA regulation of human, mouse, rat KCNS2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KCNS2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNS2 Predesigned siRNA for gene silencing in human, mouse, rat KCNS2
     QuantiFast Probe-based Assays in human, mouse, rat KCNS2 QuantiTect SYBR Green Assays in human, mouse, rat KCNS2
     Custom PCR Arrays for KCNS2 Search Chromatin IP Primers for KCNS2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNS2  Search GeneGlobe Interaction Network for KCNS2
     Regulatory tfbs in KCNS2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for KCNS2 GenScript cDNA clones with any tag delivered in your preferred vector for KCNS2
     GenScript Custom Assay Services for KCNS2 GenScript Custom overexpressing Cell Line Services for KCNS2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for KCNS2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for KCNS2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KCNS2 antibodies
     Antibodies for KCNS2
     See all of Abcam's Antibodies, Kits and Proteins for KCNS2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for KCNS2
     Antibodies for KCNS2
     ELISAs for KCNS2
     CLIAs for KCNS2



     Browse ESI BIO Cell Lines and PureStem Progenitors for KCNS2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNS2
     SwitchGear 3'UTR luciferase reporter plasmids for KCNS2
     SwitchGear Promoter luciferase reporter plasmids for KCNS2
     ThermoFisher Antibodies for KCNS2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNS2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNS2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KCNS2
     LSBio Antibodies in human, mouse, rat for KCNS2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KCNS2 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4