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Aliases for KCNS2 Gene

Aliases for KCNS2 Gene

  • Potassium Voltage-Gated Channel, Modifier Subfamily S, Member 2 2 3
  • Potassium Voltage-Gated Channel, Delayed-Rectifier, Subfamily S, Member 2 2 3
  • Delayed-Rectifier K(+) Channel Alpha Subunit 2 3 4
  • Voltage-Gated Potassium Channel Subunit Kv9.2 3 4
  • Potassium Voltage-Gated Channel Subfamily S Member 2 3
  • KIAA1144 4
  • KV9.2 3

External Ids for KCNS2 Gene

Previous GeneCards Identifiers for KCNS2 Gene

  • GC08P098448
  • GC08P099513
  • GC08P099108
  • GC08P099387
  • GC08P099395
  • GC08P099508
  • GC08P094643
  • GC08P099439

Summaries for KCNS2 Gene

GeneCards Summary for KCNS2 Gene

KCNS2 (Potassium Voltage-Gated Channel, Modifier Subfamily S, Member 2) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include delayed rectifier potassium channel activity. An important paralog of this gene is KCNB2.

UniProtKB/Swiss-Prot for KCNS2 Gene

  • Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity).

Tocris Summary for KCNS2 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNS2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNS2 Gene

Genomics for KCNS2 Gene

Regulatory Elements for KCNS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCNS2 Gene

98,427,022 bp from pter
98,432,848 bp from pter
5,827 bases
Plus strand

Genomic View for KCNS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNS2 Gene

Proteins for KCNS2 Gene

  • Protein details for KCNS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium voltage-gated channel subfamily S member 2
    Protein Accession:
    Secondary Accessions:
    • A8KAN1

    Protein attributes for KCNS2 Gene

    477 amino acids
    Molecular mass:
    54237 Da
    Quaternary structure:
    • Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins (By similarity).
    • Sequence=BAA86458.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KCNS2 Gene

Proteomics data for KCNS2 Gene at MOPED

Post-translational modifications for KCNS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNS2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNS2 Gene

Domains for KCNS2 Gene

Gene Families for KCNS2 Gene

  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels

Suggested Antigen Peptide Sequences for KCNS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9ULS6
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position
  • Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.2/KCNS2 sub-subfamily.
genes like me logo Genes that share domains with KCNS2: view

Function for KCNS2 Gene

Molecular function for KCNS2 Gene

GENATLAS Biochemistry:
potassium voltage-gated channel delayed-rectifier,subfamily Shab,member 1,highly and selectively expressed in the brain,modulator of Kv2.1,Kv2.2
UniProtKB/Swiss-Prot Function:
Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity).

Gene Ontology (GO) - Molecular Function for KCNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005251 delayed rectifier potassium channel activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KCNS2: view

Phenotypes for KCNS2 Gene

MGI mutant phenotypes for KCNS2:
inferred from 1 alleles
GenomeRNAi human phenotypes for KCNS2:
genes like me logo Genes that share phenotypes with KCNS2: view

Animal Models for KCNS2 Gene

MGI Knock Outs for KCNS2:

Animal Model Products

miRNA for KCNS2 Gene

miRTarBase miRNAs that target KCNS2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KCNS2 Gene

Localization for KCNS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNS2 Gene

Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for KCNS2 Gene COMPARTMENTS Subcellular localization image for KCNS2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KCNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with KCNS2: view

Pathways for KCNS2 Gene

genes like me logo Genes that share pathways with KCNS2: view

Pathways by source for KCNS2 Gene

1 Qiagen pathway for KCNS2 Gene

Gene Ontology (GO) - Biological Process for KCNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0007268 synaptic transmission TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051260 protein homooligomerization IEA --
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with KCNS2: view

Compounds for KCNS2 Gene

(5) Tocris Compounds for KCNS2 Gene

Compound Action Cas Number
4-Aminopyridine Non-selective KV channel blocker [504-24-5]
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
Margatoxin Potent KV1.3 channel blocker [145808-47-5]
MaxiPost Potassium channel modulator; exerts subtype-specific effects [187523-35-9]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents [122955-13-9]
genes like me logo Genes that share compounds with KCNS2: view

Transcripts for KCNS2 Gene

mRNA/cDNA for KCNS2 Gene

(20) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNS2 Gene

Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNS2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNS2 Gene

No ASD Table

Relevant External Links for KCNS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCNS2 Gene

mRNA expression in normal human tissues for KCNS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNS2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (9.1), Brain - Cortex (7.9), and Brain - Anterior cingulate cortex (BA24) (5.1).

Protein differential expression in normal tissues for KCNS2 Gene

This gene is overexpressed in Retina (28.1) and Fetal heart (27.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNS2 Gene

SOURCE GeneReport for Unigene cluster for KCNS2 Gene Hs.388045

genes like me logo Genes that share expressions with KCNS2: view

Expression partners for KCNS2 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KCNS2 Gene

Orthologs for KCNS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCNS2 35
  • 93.56 (n)
  • 98.95 (a)
KCNS2 36
  • 99 (a)
(Canis familiaris)
Mammalia KCNS2 35
  • 92.28 (n)
  • 96.84 (a)
KCNS2 36
  • 96 (a)
(Mus musculus)
Mammalia Kcns2 35
  • 90.34 (n)
  • 98.32 (a)
Kcns2 16
Kcns2 36
  • 98 (a)
(Pan troglodytes)
Mammalia KCNS2 35
  • 99.49 (n)
  • 99.75 (a)
KCNS2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Kcns2 35
  • 90.06 (n)
  • 98.32 (a)
(Monodelphis domestica)
Mammalia KCNS2 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia KCNS2 36
  • 79 (a)
(Gallus gallus)
Aves KCNS2 35
  • 78.55 (n)
  • 90.57 (a)
KCNS2 36
  • 91 (a)
(Anolis carolinensis)
Reptilia KCNS2 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kcns2 35
  • 73.86 (n)
  • 83.23 (a)
Species with no ortholog for KCNS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KCNS2 Gene

Gene Tree for KCNS2 (if available)
Gene Tree for KCNS2 (if available)

Paralogs for KCNS2 Gene

Paralogs for KCNS2 Gene

Selected SIMAP similar genes for KCNS2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNS2: view

Variants for KCNS2 Gene

Sequence variations from dbSNP and Humsavar for KCNS2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs3935841 -- 98,426,162(+) CACAC(C/T)GCTCT upstream-variant-2KB
rs4075986 -- 98,426,603(-) GAAGC(C/T)CGGGG upstream-variant-2KB
rs5893464 -- 98,425,350(+) ACACA(-/CACA)AACAC upstream-variant-2KB
rs6999732 -- 98,429,722(+) GTGTA(C/T)GCTAT utr-variant-3-prime
rs10111589 -- 98,427,778(+) CAGCC(A/T)TTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNS2 Gene

Variant ID Type Subtype PubMed ID
nsv831406 CNV Loss 17160897

Relevant External Links for KCNS2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNS2 Gene

Disorders for KCNS2 Gene

No disorders were found for KCNS2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for KCNS2 Gene

Publications for KCNS2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3
  3. New modulatory alpha subunits for mammalian Shab K+ channels. (PMID: 9305895) Salinas M. … Lazdunski M. (J. Biol. Chem. 1997) 2 3
  4. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KCNS2 Gene

Sources for KCNS2 Gene

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