Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNS1 Gene

protein-coding   GIFtS: 56
GCID: GC20M043720

potassium voltage-gated channel, delayed-rectifier, subfamily...
 Explore 5 diseases affiliated with
KCNS1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCNS1    

Aliases
for KCNS1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Potassium Voltage-Gated Channel, Delayed-Rectifier, Subfamily S, Member
11 2
     KV9.12
Delayed-Rectifier K(+) Channel Alpha Subunit 12 3     Delayed-Rectifier K+ Channel Alpha Subunit 12
Voltage-Gated Potassium Channel Subunit Kv9.12 3     Potassium Voltage-Gated Channel Subfamily S Member 12
Kv9.11     Voltage-Gated Potassium Channel Protein Kv9.12

External Ids:    HGNC: 63001   Entrez Gene: 37872   Ensembl: ENSG000001241347   OMIM: 6029055   UniProtKB: Q96KK33   

Export aliases for KCNS1 gene to outside databases

Previous GC identifers: GC20M043449 GC20M043409 GC20M044359 GC20M044406 GC20M043154 GC20M040462


Summaries
for KCNS1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KCNS1:
Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both
excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane
potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those
that are functional by themselves and those that are electrically silent but capable of modulating the activity of
specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form
heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of
potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCNS1_HUMAN, Q96KK3
Function: Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity)

summary for KCNS1:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNS1


Genomic Views
for KCNS1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNS1 gene promoter:
         AhR   TBP   STAT1   Pax-5   STAT1beta   Arnt   C/EBPalpha   STAT1alpha   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q12

KCNS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNS1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M043720:  view genomic region     (about GC identifiers)

Start:
 43,720,950 bp from pter      End:
 43,729,753 bp from pter
Size:
 8,804 bases      Orientation:
 minus strand

Proteins
for KCNS1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCNS1_HUMAN, Q96KK3 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily S member 1  
Size: 526 amino acids; 58372 Da
Subunit: Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel
proteins (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in
an intracellular compartment in the absence of KCNB1
Secondary accessions: A2RUL9 B7ZM31 O43652 Q6DJU6

Explore the universe of human proteins at neXtProt for KCNS1: NX_Q96KK3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96KK3

    • KCNS1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002242.2  
    ENSEMBL proteins: 
     ENSP00000307694   ENSP00000445595  
    Reactome Protein details: Q96KK3
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for KCNS1 
    GenScript Custom Purified and Recombinant Proteins Services for KCNS1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KCNS1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IDA10484328


    KCNS1 for ontologies           About GeneDecksing



    KCNS1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KCNS1 
    GenScript Custom Superior Antibodies Services for KCNS1
    Novus Biologicals KCNS1 Antibodies
    Search for Antibodies for KCNS1 at Abcam  
    Uscn Antibodies for KCNS1
    Search ThermoFisher Antibodies for KCNS1

    Assay Products for KCNS1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KCNS1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for KCNS1

    Protein Domains /
    Families
    for KCNS1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCNS1 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR005821 Ion_trans_dom
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003971 K_chnl_volt-dep_Kv9
     IPR003968 K_chnl_volt-dep_Kv

    Graphical View of Domain Structure for InterPro Entry Q96KK3

    ProtoNet protein and cluster: Q96KK3

    3 Blocks protein families:
    IPB000210 BTB/POZ domain
    IPB003091 Potassium channel signature
    IPB003971 Kv9 potassium channel alpha subunit signature


    UniProtKB/Swiss-Prot: KCNS1_HUMAN, Q96KK3
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily


    Function
    for KCNS1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCNS1_HUMAN, Q96KK3
    Function: Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: KCNS1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNS1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNS1 (see all 9):
    hsa-miR-1266 hsa-miR-3130-3p hsa-miR-624 hsa-miR-1205 hsa-miR-3907 hsa-miR-4298 hsa-miR-1302 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmid: KCNS1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNS1 (see all 7)
    OriGene shRNA RFP: KCNS1
    OriGene siRNA: KCNS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNS1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for KCNS1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNS1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNS1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KCNS1 (NM_002251)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNS1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for KCNS1
    Search LifeMap BioReagents cell lines for KCNS1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNS1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005251delayed rectifier potassium channel activity IDA10484328
    GO:0005515protein binding IPI10484328
    GO:0015459potassium channel regulator activity IDA10484328


    KCNS1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for KCNS1:
     Increased cell number in G2M,   Synthetic lethal with c-Myc af 


    Pathways & Interactions
    for KCNS1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Potassium Channels
    		Potassium Channels1.00
    		Voltage gated Potassium channels0.43
    2Dopamine-DARPP32 Feedback onto cAMP Pathway
    		Dopamine-DARPP32 Feedback onto cAMP Pathway1.00
    3Transmission across Chemical Synapses
    		Neuronal System0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNS1
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    3        Reactome Pathways for KCNS1
        Potassium Channels
    Neuronal System
    Voltage gated Potassium channels



    KCNS1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/41 Interacting proteins for KCNS1 (ENSP000003076944) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNA10ENSP000003587864STRING: ENSP00000358786
    KCNA2ENSP000003145204STRING: ENSP00000314520
    KCNA3ENSP000003587844STRING: ENSP00000358784
    KCNA6ENSP000002806844STRING: ENSP00000280684
    KCNA7ENSP000002214444STRING: ENSP00000221444
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport TAS10484328
    GO:0007268synaptic transmission TAS--
    GO:0051260protein homooligomerization IEA--


    KCNS1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCNS1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNS1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AM 92016 hydrochlorideKV channel blocker[178894-81-0]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    4-AminopyridineNon-selective KV channel blocker[504-24-5]
    Search CenterWatch for drugs/clinical trials and news about KCNS1 

    Transcripts
    for KCNS1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCNS1 gene: 
    NM_002251.3  

    Unigene Cluster for KCNS1:

    Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
    Hs.117780  [show with all ESTs]
    Unigene Representative Sequence: AF043473
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306117(uc002xnc.3 uc002xnd.3) ENST00000537075

    miRNA
    Products:             		 OriGene 3'-UTR Clone: KCNS1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNS1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNS1 (see all 9):
    hsa-miR-1266 hsa-miR-3130-3p hsa-miR-624 hsa-miR-1205 hsa-miR-3907 hsa-miR-4298 hsa-miR-1302 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmid: KCNS1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNS1 (see all 7)
    OriGene shRNA RFP: KCNS1
    OriGene siRNA: KCNS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNS1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNS1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNS1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KCNS1 (NM_002251)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNS1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNS1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNS1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNS1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNS1

    Additional cDNA sequence: 

    AF043473.2 AK289735.1 BC075033.2 BC075034.2 BC132957.1 BC132959.1 BC144234.1 

    3 DOTS entries:

    DT.212165  DT.120821695  DT.120821696 

    24/29 AceView cDNA sequences (see all 29):

    BC075034 BC075033 H43697 NM_002251 H51391 BF914751 AF043473 H49525 
    BF914749 T08732 H18164 H20175 AA788916 H18119 BF037198 H49759 
    CD614379 CD614377 H85454 BE819000 H43171 R88616 H20365 H51390 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for KCNS1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
    SP1:                                    
    SP2:        -                           


    ECgene alternative splicing isoforms for KCNS1

    Expression
    for KCNS1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATCAGTGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KCNS1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    HyStem+TGF?3+GDF5-induced SM30 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    HyStem+BMP4-induced SM30 cells (HyStem+BMP4 inductio...)Adipose, Bone, Cartilage
    TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)Bone, Cartilage
    HyStem+TGF?3+GDF5-induced E15 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KCNS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNS1

    SOURCE GeneReport for Unigene cluster: Hs.117780

    UniProtKB/Swiss-Prot: KCNS1_HUMAN, Q96KK3
    Tissue specificity: Detected in all tissues tested with the exception of skeletal muscle. Highly expressed in adult and
    fetal brain, fetal kidney and lung, and adult prostate and testis

        SABiosciences Expression via Pathway-Focused PCR Array including KCNS1: 
              Neuronal Ion Channels in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNS1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNS1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNS1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNS1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNS1

    Orthologs
    for KCNS1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KCNS1 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KCNS11 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 less 74.89(n)
    72.47(a)    		   770173  XM_001232666.2  XP_001232667.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KCNS16
    		 --
    		 71(a)
    		 1 ↔ 1
    		 4(143384323-143399328)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1001482901 potassium voltage-gated channel subfamily S member 1-like less 63.33(n)
    65.39(a)    		   100148290  XM_001922158.1  XP_001922193.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 25(a)
    		 possible ortholog
    		 Group13.15(957-3745)
    worm
    (Caenorhabditis elegans)    		 Secernentea F44A2.23 potassium channel protein 32(a)
    (best of 2)    		   V(9320822-9321939)   --


    ENSEMBL Gene Tree for KCNS1 (if available)
    TreeFam Gene Tree for KCNS1 (if available) 

    Paralogs
    for KCNS1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNS1 gene
    KCNG32  KCNF12  KCNB22  KCNV12  KCNG22  KCNS22  KCNS32  KCNB12  
    KCNV22  KCNG42  KCNG12  
    18/24 SIMAP similar genes for KCNS1 using alignment to 2 protein entries:     KCNS1_HUMAN (see all proteins) (see all similar genes):
    KCNS2    KCNS3    KCNB1    KCNB2    KCNG1    KCNV2
    KCNA7    KCNG4    KCNG2    KCNG3    KCNV1    KCNA10
    KCNF1    KCNA1    KCNA2    KCNA3    KCNC1    KCNC2

    KCNS1 for paralogs           About GeneDecksing



    Genomic Variants
    for KCNS1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/185 NCBI SNPs in KCNS1 are shown (see all 185)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1122439181,2
    		--43720474(+) ACCACC/AAACTA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1908755481,2
    		--43720558(+) TTTCTA/GGCCTC 1 -- ds50010--------
    rs1146330021,2
    		F,--43720646(+) CTAATA/GTATCT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs60736391,2
    		C,F,--43720812(+) CTGGCA/GCAACC 1 -- ds500110Minor allele frequency- G:0.16NA WA EA 488
    rs1833548081,2
    		--43720861(+) TGTGGA/GTTCCA 1 -- ds50010--------
    rs1491672201,2
    		--43720897(+) CTCCAA/GTCACT 1 -- ds50010--------
    rs1433233931,2
    		--43720907(+) TCAGAC/TAGCAT 1 -- ds50010--------
    rs1180921791,2
    		F,--43720948(+) CACGTC/TCTGGG 1 -- ds50011Minor allele frequency- T:0.02NA 120
    rs1869444341,2
    		--43721005(+) GGGAGC/TGAGTT 1 -- ut310--------
    rs1913649891,2
    		--43721263(+) GTGTGA/GTGAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KCNS1 (43720950 - 43729753 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KCNS1: --
    Human Gene Mutation Database (HGMD): KCNS1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNS1
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNS1

    Disorders / Diseases
    for KCNS1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCNS1 for disorders           About GeneDecksing

    OMIM gene information: 602905    OMIM disorders: --

    5 diseases for KCNS1:    About MalaCards
    chronic pain    fainting    pharyngitis    prostatitis
    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: KCNS1 (1 document)

    Export disorders for KCNS1 gene to outside databases

    Publications
    for KCNS1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNS1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KCNS1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    4. Electrically silent potassium channel subunits from human lens epithelium. (PubMed id 10484328)1, 2 Shepard A.R. and Rae J.L. (1999)
    5. New modulatory alpha subunits for mammalian Shab K+ channels. (PubMed id 9305895)1, 3 Salinas M....Lazdunski M. (1997)
    6. Multiple chronic pain states are associated with a co mmon amino acid-changing allele in KCNS1. (PubMed id 20724292)1 Costigan M....Woolf C.J. (2010)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20. (PubMed id 11549316)1 Fossey S.C....Bowden D.W. (2001)
    9. Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells. (PubMed id 16815889)9 Fantozzi I....Yuan J.X. (2006)

    External Searches for KCNS1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KCNS1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3787 HGNC: 6300 AceView: KCNS1 Ensembl:ENSG00000124134 euGenes: HUgn3787
    ECgene: KCNS1 H-InvDB: KCNS1

    Other Databases showing KCNS1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCNS1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNS1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCNS1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCNS1 gene:
    Search GeneIP for patents involving KCNS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for KCNS1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for KCNS1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNS1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNS1  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for KCNS1   OriGene 3'-UTR Clone for KCNS1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNS1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNS1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KCNS1   OriGene Custom Protein Services for KCNS1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNS1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNS1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNS1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNS1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNS1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNS1
     GenScript Custom Purified and Recombinant Proteins Services for KCNS1 GenScript cDNA clones with any tag delivered in your preferred vector for KCNS1
     GenScript Custom Assay Services for KCNS1 GenScript Custom Superior Antibodies Services for KCNS1
     GenScript Custom overexpressing Cell Line Services for KCNS1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KCNS1 promoter
     Search Chromatin IP Primers for KCNS1
     RT2 qPCR Primer Assay in human, mouse, rat KCNS1
     GNC Network for KCNS1
     SABiosciences PCR Arrays including human, mouse, rat KCNS1
     Tocris compounds for KCNS1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KCNS1 antibodies
     Search for Antibodies for KCNS1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for KCNS1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     KCNS1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for KCNS1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNS1
     SwitchGear 3'UTR luciferase reporter plasmids for KCNS1
     SwitchGear Promoter luciferase reporter plasmids for KCNS1
     Search ThermoFisher Antibodies for KCNS1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNS1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      KCNS1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4