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Aliases for KCNS1 Gene

Aliases for KCNS1 Gene

  • Potassium Voltage-Gated Channel, Modifier Subfamily S, Member 1 2 3
  • Potassium Voltage-Gated Channel, Delayed-Rectifier, Subfamily S, Member 1 2 3
  • Delayed-Rectifier K(+) Channel Alpha Subunit 1 3 4
  • Voltage-Gated Potassium Channel Subunit Kv9.1 3 4
  • Voltage-Gated Potassium Channel Protein Kv9.1 3
  • Delayed-Rectifier K+ Channel Alpha Subunit 1 3
  • KV9.1 3

External Ids for KCNS1 Gene

Previous GeneCards Identifiers for KCNS1 Gene

  • GC20M043449
  • GC20M043409
  • GC20M044359
  • GC20M044406
  • GC20M043154
  • GC20M043720
  • GC20M040462

Summaries for KCNS1 Gene

Entrez Gene Summary for KCNS1 Gene

  • Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNS1 Gene

KCNS1 (Potassium Voltage-Gated Channel, Modifier Subfamily S, Member 1) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include ion channel activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNB2.

UniProtKB/Swiss-Prot for KCNS1 Gene

  • Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2 (PubMed:10484328).

Tocris Summary for KCNS1 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNS1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNS1 Gene

Genomics for KCNS1 Gene

Regulatory Elements for KCNS1 Gene

Genomic Location for KCNS1 Gene

Chromosome:
20
Start:
45,092,072 bp from pter
End:
45,101,112 bp from pter
Size:
9,041 bases
Orientation:
Minus strand

Genomic View for KCNS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNS1 Gene

Proteins for KCNS1 Gene

  • Protein details for KCNS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KK3-KCNS1_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily S member 1
    Protein Accession:
    Q96KK3
    Secondary Accessions:
    • A2RUL9
    • B7ZM31
    • O43652
    • Q6DJU6

    Protein attributes for KCNS1 Gene

    Size:
    526 amino acids
    Molecular mass:
    58372 Da
    Quaternary structure:
    • Heterotetramer with KCNB1 (PubMed:10484328). Heterotetramer with KCNB2 (By similarity). Does not form homomultimers (PubMed:10484328).

neXtProt entry for KCNS1 Gene

Proteomics data for KCNS1 Gene at MOPED

Post-translational modifications for KCNS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNS1 Gene

Domains & Families for KCNS1 Gene

Gene Families for KCNS1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96KK3

UniProtKB/Swiss-Prot:

KCNS1_HUMAN :
  • The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
  • Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily.
Domain:
  • The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
Family:
  • Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily.
genes like me logo Genes that share domains with KCNS1: view

Function for KCNS1 Gene

Molecular function for KCNS1 Gene

UniProtKB/Swiss-Prot Function:
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2 (PubMed:10484328).

Gene Ontology (GO) - Molecular Function for KCNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005251 delayed rectifier potassium channel activity IDA 10484328
GO:0005515 protein binding IPI 10484328
GO:0015459 potassium channel regulator activity IDA 10484328
genes like me logo Genes that share ontologies with KCNS1: view
genes like me logo Genes that share phenotypes with KCNS1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KCNS1 Gene

Localization for KCNS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNS1 Gene

Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2 (PubMed:10484328). {ECO:0000269 PubMed:10484328}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNS1 Gene COMPARTMENTS Subcellular localization image for KCNS1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for KCNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IDA 10484328
GO:0016020 membrane --
GO:0016021 integral component of membrane IBA --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with KCNS1: view

Pathways & Interactions for KCNS1 Gene

genes like me logo Genes that share pathways with KCNS1: view

Pathways by source for KCNS1 Gene

1 Qiagen pathway for KCNS1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for KCNS1 Gene

Gene Ontology (GO) - Biological Process for KCNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006813 potassium ion transport TAS 10484328
GO:0007268 synaptic transmission TAS --
GO:0051260 protein homooligomerization IEA --
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with KCNS1: view

No data available for SIGNOR curated interactions for KCNS1 Gene

Drugs & Compounds for KCNS1 Gene

(1) Drugs for KCNS1 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Flupirtine maleate Pharma KV7 channel activator 0

(3) Additional Compounds for KCNS1 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Kaliotoxin
145199-73-1
L-364,373
103342-82-1
PD 118057
313674-97-4
genes like me logo Genes that share compounds with KCNS1: view

Transcripts for KCNS1 Gene

mRNA/cDNA for KCNS1 Gene

Unigene Clusters for KCNS1 Gene

Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNS1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1:
SP2: -

Relevant External Links for KCNS1 Gene

GeneLoc Exon Structure for
KCNS1
ECgene alternative splicing isoforms for
KCNS1

Expression for KCNS1 Gene

mRNA expression in normal human tissues for KCNS1 Gene

mRNA differential expression in normal tissues according to GTEx for KCNS1 Gene

This gene is overexpressed in Brain - Cortex (x18.5), Brain - Frontal Cortex (BA9) (x16.5), and Brain - Anterior cingulate cortex (BA24) (x9.4).

Protein differential expression in normal tissues from HIPED for KCNS1 Gene

This gene is overexpressed in Blymphocyte (27.6), Heart (21.8), and Adipocyte (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNS1 Gene



SOURCE GeneReport for Unigene cluster for KCNS1 Gene Hs.117780

mRNA Expression by UniProt/SwissProt for KCNS1 Gene

Q96KK3-KCNS1_HUMAN
Tissue specificity: Detected in all tissues tested with the exception of skeletal muscle. Highly expressed in adult and fetal brain, fetal kidney and lung, and adult prostate and testis (PubMed:10484328).
genes like me logo Genes that share expression patterns with KCNS1: view

Protein tissue co-expression partners for KCNS1 Gene

Primer Products

In Situ Assay Products

Orthologs for KCNS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNS1 35
  • 90.24 (n)
  • 90.87 (a)
KCNS1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNS1 35
  • 90.98 (n)
  • 91.31 (a)
KCNS1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcns1 35
  • 88.39 (n)
  • 90.28 (a)
Kcns1 16
Kcns1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNS1 35
  • 99.75 (n)
  • 99.43 (a)
KCNS1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcns1 35
  • 88.46 (n)
  • 90.89 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNS1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNS1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNS1 35
  • 75.04 (n)
  • 72.25 (a)
KCNS1 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNS1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcns1 35
  • 64.9 (n)
  • 67.59 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-43k4.5 35
  • 63.17 (n)
  • 65.24 (a)
KCNS1 36
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C32C4.1 37
  • 32 (a)
F44A2.2 37
  • 32 (a)
Species with no ortholog for KCNS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNS1 Gene

ENSEMBL:
Gene Tree for KCNS1 (if available)
TreeFam:
Gene Tree for KCNS1 (if available)

Paralogs for KCNS1 Gene

Paralogs for KCNS1 Gene

(24) SIMAP similar genes for KCNS1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCNS1: view

Variants for KCNS1 Gene

Sequence variations from dbSNP and Humsavar for KCNS1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs734784 - 45,094,986(-) GCAGC(A/G)TTGAT reference, missense
rs962550 -- 45,097,086(-) GGTTG(A/G)AGGGT intron-variant
rs1054136 -- 45,093,935(+) TTGCC(C/T)TCTGG utr-variant-3-prime
rs3213543 -- 45,101,030(+) AGCCT(C/T)CTGCT utr-variant-5-prime
rs4499491 -- 45,092,778(+) TCCCC(A/C)CTGGA utr-variant-3-prime

Variation tolerance for KCNS1 Gene

Residual Variation Intolerance Score: 56.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNS1 Gene

HapMap Linkage Disequilibrium report
KCNS1
Human Gene Mutation Database (HGMD)
KCNS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KCNS1 Gene

Disorders for KCNS1 Gene

Relevant External Links for KCNS1

Genetic Association Database (GAD)
KCNS1
Human Genome Epidemiology (HuGE) Navigator
KCNS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNS1
genes like me logo Genes that share disorders with KCNS1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNS1 Gene

Publications for KCNS1 Gene

  1. Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells. (PMID: 16815889) Fantozzi I. … Yuan J.X. (Am. J. Physiol. Lung Cell Mol. Physiol. 2006) 23 67
  2. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 67
  3. New modulatory alpha subunits for mammalian Shab K+ channels. (PMID: 9305895) Salinas M. … Lazdunski M. (J. Biol. Chem. 1997) 2 67
  4. Variations in Potassium Channel Genes Are Associated With Breast Pain in Women Prior to Breast Cancer Surgery. (PMID: 24392765) Langford D.J. … Miaskowski C. (J. Neurogenet. 2014) 67
  5. Biopsychosocial influence on exercise-induced injury: genetic and psychological combinations are predictive of shoulder pain phenotypes. (PMID: 24373571) George S.Z. … Fillingim R.B. (J Pain 2014) 67

Products for KCNS1 Gene

Sources for KCNS1 Gene

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