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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNS1 Gene

protein-coding   GIFtS: 58
GCID: GC20M043720

Potassium Voltage-Gated Channel, Delayed-Rectifier, Subfamily...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Voltage-Gated Channel, Delayed-Rectifier, Subfamily S, Member
11 2
     Delayed-Rectifier K+ Channel Alpha Subunit 12
Delayed-Rectifier K(+) Channel Alpha Subunit 12 3     Potassium Voltage-Gated Channel Subfamily S Member 12
Voltage-Gated Potassium Channel Subunit Kv9.12 3     Voltage-Gated Potassium Channel Protein Kv9.12
KV9.12     

External Ids:    HGNC: 63001   Entrez Gene: 37872   Ensembl: ENSG000001241347   OMIM: 6029055   UniProtKB: Q96KK33   

Export aliases for KCNS1 gene to outside databases

Previous GC identifers: GC20M043449 GC20M043409 GC20M044359 GC20M044406 GC20M043154 GC20M040462


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNS1 Gene:
Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in
both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting
membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2
types: those that are functional by themselves and those that are electrically silent but capable of modulating
the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself
but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related
subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium
channel family. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNS1 Gene: 
KCNS1 (potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1) is a protein-coding gene. Diseases associated with KCNS1 include chronic pain, and fainting, and among its related super-pathways are Potassium Channels and Transmission across Chemical Synapses. GO annotations related to this gene include delayed rectifier potassium channel activity and potassium channel regulator activity. An important paralog of this gene is KCNF1.

UniProtKB/Swiss-Prot: KCNS1_HUMAN, Q96KK3
Function: Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity)

summary for KCNS1 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNS1 gene promoter:
         AhR   TBP   STAT1   Pax-5   STAT1beta   Arnt   C/EBPalpha   STAT1alpha   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q12

KCNS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNS1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M043720:  view genomic region     (about GC identifiers)

Start:
43,720,950 bp from pter      End:
43,729,753 bp from pter
Size:
8,804 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCNS1_HUMAN, Q96KK3 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily S member 1  
Size: 526 amino acids; 58372 Da
Subunit: Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel
proteins (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but
remain in an intracellular compartment in the absence of KCNB1
Secondary accessions: A2RUL9 B7ZM31 O43652 Q6DJU6

Explore the universe of human proteins at neXtProt for KCNS1: NX_Q96KK3

Explore proteomics data for KCNS1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96KK3

  • KCNS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCNS1 Protein Expression
    REFSEQ proteins: NP_002242.2  
    ENSEMBL proteins: 
     ENSP00000307694   ENSP00000445595  
    Reactome Protein details: Q96KK3
    Human Recombinant Protein Products for KCNS1: 
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    Cloud-Clone Corp. Proteins for KCNS1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IDA10484328
    GO:0016020membrane ----

    KCNS1 for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for KCNS1 

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    Cloud-Clone Corp. CLIAs for KCNS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KCN: Potassium channels
    Kv: Voltage-gated ion channels / Potassium channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kv9.1 
    Voltage-gated potassium channels

    5/8 InterPro protein domains (see all 8):
     IPR005821 Ion_trans_dom
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR027359 K_channel_four-helix_dom
     IPR003971 K_chnl_volt-dep_Kv9

    Graphical View of Domain Structure for InterPro Entry Q96KK3

    ProtoNet protein and cluster: Q96KK3

    3 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB003091 Potassium channel signature
    IPB003971 Kv9 potassium channel alpha subunit signature


    UniProtKB/Swiss-Prot: KCNS1_HUMAN, Q96KK3
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily


    KCNS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNS1_HUMAN, Q96KK3
    Function: Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005251delayed rectifier potassium channel activity IDA10484328
    GO:0005515protein binding IPI10484328
    GO:0015459potassium channel regulator activity IDA10484328
         
    KCNS1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for KCNS1:
     Increased cell number in G2M,   Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KCNS1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KCNS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCNS1 
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    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNS1 (see all 9):
    hsa-miR-1266 hsa-miR-3130-3p hsa-miR-624 hsa-miR-1205 hsa-miR-3907 hsa-miR-4298 hsa-miR-1302 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidKCNS1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNS1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KCNS1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Voltage gated Potassium channels0.43
    2Transmission across Chemical Synapses
    Neuronal System0.67
    3Dopamine-DARPP32 Feedback onto cAMP Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNS1
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    3        Reactome Pathways for KCNS1
        Potassium Channels
    Neuronal System
    Voltage gated Potassium channels



    KCNS1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/41 Interacting proteins for KCNS1 (ENSP000003076944) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNA10ENSP000003587864STRING: ENSP00000358786
    KCNA2ENSP000003145204STRING: ENSP00000314520
    KCNA3ENSP000003587844STRING: ENSP00000358784
    KCNA6ENSP000002806844STRING: ENSP00000280684
    KCNA7ENSP000002214444STRING: ENSP00000221444
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006813potassium ion transport TAS10484328
    GO:0007268synaptic transmission TAS--
    GO:0051260protein homooligomerization IEA--
    GO:0055085transmembrane transport ----

    KCNS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNS1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    Search CenterWatch for drugs/clinical trials and news about KCNS1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KCNS1 gene: 
    NM_002251.3  

    Unigene Cluster for KCNS1:

    Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
    Hs.117780  [show with all ESTs]
    Unigene Representative Sequence: AF043473
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306117(uc002xnc.3 uc002xnd.3) ENST00000537075
    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNS1 (see all 9):
    hsa-miR-1266 hsa-miR-3130-3p hsa-miR-624 hsa-miR-1205 hsa-miR-3907 hsa-miR-4298 hsa-miR-1302 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidKCNS1 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNS1
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNS1

    Additional mRNA sequence: 

    AF043473.2 AK289735.1 BC075033.2 BC075034.2 BC132957.1 BC132959.1 BC144234.1 

    3 DOTS entries:

    DT.212165  DT.120821695  DT.120821696 

    24/29 AceView cDNA sequences (see all 29):

    H51391 BC075033 NM_002251 BC075034 H43697 BF914751 BF914749 AF043473 
    H49525 H20175 AA788916 H18164 T08732 H18119 BF037198 H49759 
    BE819000 H43171 CD614379 CD614377 H85454 H20365 R88616 H51390 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for KCNS1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
    SP1:                                    
    SP2:        -                           


    ECgene alternative splicing isoforms for KCNS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNS1 expression in normal human tissues (normalized intensities)      KCNS1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCAGTGAA
    KCNS1 Expression
    About this image


    KCNS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Cartilage (Muscoskeletal System)    fully expand to see all 6 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             umbilical cord reticulocytes   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor

    See KCNS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNS1

    SOURCE GeneReport for Unigene cluster: Hs.117780

    UniProtKB/Swiss-Prot: KCNS1_HUMAN, Q96KK3
    Tissue specificity: Detected in all tissues tested with the exception of skeletal muscle. Highly expressed in
    adult and fetal brain, fetal kidney and lung, and adult prostate and testis

        SABiosciences Expression via Pathway-Focused PCR Array including KCNS1: 
              Neuronal Ion Channels in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KCNS1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcns11 , 5 K+ voltage-gated channel, subfamily S, 11, 5 88.51(n)1
    90.47(a)1
      2 (84.60 cM)5
    165381  NM_008435.21  NP_032461.21 
     1641636195 
    chicken
    (Gallus gallus)
    Aves KCNS11 potassium voltage-gated channel, delayed-rectifier, more 74.89(n)
    72.47(a)
      770173  XM_001232666.2  XP_001232667.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNS16
    Uncharacterized protein
    68(a)
    1 ↔ 1
    4(143321855-143399346)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001482901 potassium voltage-gated channel subfamily S member more 63.33(n)
    65.39(a)
      100148290  XM_001922158.1  XP_001922193.1 


    ENSEMBL Gene Tree for KCNS1 (if available)
    TreeFam Gene Tree for KCNS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNS1 gene
    KCNF12  KCNG32  KCNB22  KCNV12  KCNG22  KCNS22  KCNS32  KCNB12  
    KCNV22  KCNG42  KCNG12  
    18/24 SIMAP similar genes for KCNS1 using alignment to 2 protein entries:     KCNS1_HUMAN (see all proteins) (see all similar genes):
    KCNS2    KCNS3    KCNB1    KCNB2    KCNG1    KCNV2
    KCNA7    KCNG4    KCNG2    KCNG3    KCNV1    KCNA10
    KCNF1    KCNA1    KCNA2    KCNA3    KCNC1    KCNC2

    KCNS1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/229 SNPs in KCNS1 are shown (see all 229)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1122439181,2
    C,F--43720474(+) ACCACC/AAACTA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1908755481,2
    --43720558(+) TTTCTA/GGCCTC 1 -- ds50010--------
    rs1146330021,2
    F--43720646(+) CTAATA/GTATCT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs60736391,2
    C,F--43720812(+) CTGGCA/GCAACC 1 -- ds500110Minor allele frequency- G:0.16NA WA EA 488
    rs1833548081,2
    --43720861(+) TGTGGA/GTTCCA 1 -- ds50010--------
    rs1491672201,2
    --43720897(+) CTCCAA/GTCACT 1 -- ds50010--------
    rs1433233931,2
    --43720907(+) TCAGAC/TAGCAT 1 -- ds50010--------
    rs1180921791,2
    C,F--43720948(+) CACGTC/TCTGGG 1 -- ds50011Minor allele frequency- T:0.02NA 120
    rs1869444341,2
    --43721005(+) GGGAGC/TGAGTT 1 -- ut310--------
    rs1913649891,2
    --43721263(+) GTGTGA/GTGAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KCNS1 (43720950 - 43729753 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KCNS1: --

    Human Gene Mutation Database (HGMD): KCNS1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNS1
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602905    OMIM disorders: --

    4 diseases for KCNS1:    About MalaCards
    chronic pain    fainting    neuronitis    prostatitis


    KCNS1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KCNS1
    Human Genome Epidemiology (HuGE) Navigator: KCNS1 (1 document)

    Export disorders for KCNS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNS1 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with KCNS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Multiple chronic pain states are associated with a co mmon amino acid-changing allele in KCNS1. (PubMed id 20724292)1, 4 Costigan M....Woolf C.J. (2010)
    2. International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    5. Electrically silent potassium channel subunits from human lens epithelium. (PubMed id 10484328)1, 2 Shepard A.R. and Rae J.L. (1999)
    6. New modulatory alpha subunits for mammalian Shab K+ channels. (PubMed id 9305895)1, 3 Salinas M....Lazdunski M. (1997)
    7. KCNS1, but not GCH1, is associated with pain intensity in a black southern African population with HIV-associated sensory neuropathy: a genetic association study. (PubMed id 23314412)1 Hendry L....Kamerman P. (2013)
    8. A genome-wide association study of seasonal pattern ma nia identifies NF1A as a possible susceptibility gene for bipolar disorder. (PubMed id 22925353)1 Lee H.J....Kelsoe J.R. (2013)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20. (PubMed id 11549316)1 Fossey S.C....Bowden D.W. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3787 HGNC: 6300 AceView: KCNS1 Ensembl:ENSG00000124134 euGenes: HUgn3787
    ECgene: KCNS1 H-InvDB: KCNS1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCNS1 gene:
    Search GeneIP for patents involving KCNS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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