Aliases for KCNS1 Gene
- Potassium Voltage-Gated Channel, Modifier Subfamily S, Member 1 2 3
- Potassium Voltage-Gated Channel, Delayed-Rectifier, Subfamily S, Member 1 2 3
- Delayed-Rectifier K(+) Channel Alpha Subunit 1 3 4
- Voltage-Gated Potassium Channel Subunit Kv9.1 3 4
- KV9.1 3 6
- Potassium Voltage-Gated Channel Subfamily S Member 1 3
- Voltage-Gated Potassium Channel Protein Kv9.1 3
- Delayed-Rectifier K+ Channel Alpha Subunit 1 3
External Ids for KCNS1 Gene
Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNS1 Gene
KCNS1 (Potassium Voltage-Gated Channel, Modifier Subfamily S, Member 1) is a Protein Coding gene. Diseases associated with KCNS1 include chronic pain. Among its related pathways are Transmission across Chemical Synapses and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include delayed rectifier potassium channel activity and potassium channel regulator activity. An important paralog of this gene is KCNB2.
UniProtKB/Swiss-Prot for KCNS1 Gene
Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity).
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.