Aliases for KCNS1 Gene
- Potassium Voltage-Gated Channel Modifier Subfamily S Member 1 2 3
- Potassium Voltage-Gated Channel, Modifier Subfamily S, Member 1 2 3 5
- Potassium Voltage-Gated Channel, Delayed-Rectifier, Subfamily S, Member 1 2 3
- Delayed-Rectifier K(+) Channel Alpha Subunit 1 3 4
- Voltage-Gated Potassium Channel Subunit Kv9.1 3 4
- Kv9.1 3
External Ids for KCNS1 Gene
Previous GeneCards Identifiers for KCNS1 Gene
Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNS1 Gene
KCNS1 (Potassium Voltage-Gated Channel Modifier Subfamily S Member 1) is a Protein Coding gene. Diseases associated with KCNS1 include chronic pain. Among its related pathways are Dopamine-DARPP32 Feedback onto cAMP Pathway and Transmission across Chemical Synapses. GO annotations related to this gene include ion channel activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNB1.
UniProtKB/Swiss-Prot for KCNS1 Gene
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2 (PubMed:10484328).
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.