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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KCNS1 Gene

protein-coding GIFtS: 56
GCID: GC20M043720

potassium voltage-gated channel, delayed-rectifier, subfamily...

Explore 5 diseases affiliated with
KCNS1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Potassium Voltage-Gated Channel, Delayed-Rectifier, Subfamily S, Member 1¹ ²		KV9.1²
Delayed-Rectifier K(+) Channel Alpha Subunit 1² ³		Delayed-Rectifier K+ Channel Alpha Subunit 1²
Voltage-Gated Potassium Channel Subunit Kv9.1² ³		Potassium Voltage-Gated Channel Subfamily S Member 1²
Kv9.1¹		Voltage-Gated Potassium Channel Protein Kv9.1²

External Ids:	HGNC: 6300¹	Entrez Gene: 3787²	Ensembl: ENSG00000124134⁷	OMIM: 602905⁵	UniProtKB: Q96KK3³

Export aliases for KCNS1 gene to outside databases

Previous GC identifers: GC20M043449 GC20M043409 GC20M044359 GC20M044406 GC20M043154 GC20M040462

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNS1:

Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both

excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane

potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those

that are functional by themselves and those that are electrically silent but capable of modulating the activity of

specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form

heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of

potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCNS1_HUMAN, Q96KK3

Function: Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity)

summary for KCNS1:

Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the

Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits

contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed

within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KCNS1 gene promoter:
AhR TBP STAT1 Pax-5 STAT1beta Arnt C/EBPalpha STAT1alpha E2F E2F-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNS1 promoter sequence

Search SABiosciences Chromatin IP Primers for KCNS1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNS1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q12

KCNS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNS1 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M043720: view genomic region (about GC identifiers)

Start:	43,720,950 bp from pter	End:	43,729,753 bp from pter
Size:	8,804 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KCNS1_HUMAN, Q96KK3 (See protein sequence)

Recommended Name: Potassium voltage-gated channel subfamily S member 1

Size: 526 amino acids; 58372 Da

Subunit: Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel

proteins (By similarity)

Subcellular location: Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in

an intracellular compartment in the absence of KCNB1

Secondary accessions: A2RUL9 B7ZM31 O43652 Q6DJU6

Explore the universe of human proteins at neXtProt for KCNS1: NX_Q96KK3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96KK3

KCNS1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002242.2

ENSEMBL proteins:

ENSP00000307694 ENSP00000445595

Reactome Protein details: Q96KK3
Human Recombinant Protein Products:

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	Uscn Proteins for KCNS1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0008076	voltage-gated potassium channel complex	IDA	10484328

KCNS1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for KCNS1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KCNS1 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR005821 Ion_trans_dom

IPR000210 BTB/POZ-like

IPR011333 BTB/POZ_fold

IPR003971 K_chnl_volt-dep_Kv9

IPR003968 K_chnl_volt-dep_Kv

Graphical View of Domain Structure for InterPro Entry Q96KK3

ProtoNet protein and cluster: Q96KK3

3 Blocks protein families:

IPB000210 BTB/POZ domain

IPB003091 Potassium channel signature

IPB003971 Kv9 potassium channel alpha subunit signature

UniProtKB/Swiss-Prot: KCNS1_HUMAN, Q96KK3

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino

acids at every third position

Similarity: Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KCNS1_HUMAN, Q96KK3

Function: Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: KCNS1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNS1
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNS1 (see all 9):
		hsa-miR-1266 hsa-miR-3130-3p hsa-miR-624 hsa-miR-1205 hsa-miR-3907 hsa-miR-4298 hsa-miR-1302 hsa-miR-149

		SwitchGear 3'UTR luciferase reporter plasmid: KCNS1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNS1 (see all 7) OriGene shRNA RFP: KCNS1 OriGene siRNA: KCNS1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNS1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for KCNS1

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNS1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNS1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KCNS1 (NM_002251)
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		Search LifeMap BioReagents cell lines for KCNS1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNS1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005251	delayed rectifier potassium channel activity	IDA	10484328
GO:0005515	protein binding	IPI	10484328
GO:0015459	potassium channel regulator activity	IDA	10484328

KCNS1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for KCNS1:

Increased cell number in G2M,

Synthetic lethal with c-Myc af

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Potassium Channels

Potassium Channels

1.00

Voltage gated Potassium channels

0.43

Dopamine-DARPP32 Feedback onto cAMP Pathway

Dopamine-DARPP32 Feedback onto cAMP Pathway

1.00

Transmission across Chemical Synapses

Neuronal System

0.67

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNS1

Dopamine-DARPP32 Feedback onto cAMP Pathway

3 Reactome Pathways for KCNS1

	Potassium Channels
	Neuronal System
	Voltage gated Potassium channels

KCNS1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KCNS1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/41 Interacting proteins for KCNS1 (ENSP00000307694⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 41)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KCNA10	ENSP00000358786⁴	STRING: ENSP00000358786
KCNA2	ENSP00000314520⁴	STRING: ENSP00000314520
KCNA3	ENSP00000358784⁴	STRING: ENSP00000358784
KCNA6	ENSP00000280684⁴	STRING: ENSP00000280684
KCNA7	ENSP00000221444⁴	STRING: ENSP00000221444

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006813	potassium ion transport	TAS	10484328
GO:0007268	synaptic transmission	TAS	--
GO:0051260	protein homooligomerization	IEA	--

KCNS1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for KCNS1 available from Tocris Bioscience About this table

Compound	Action	CAS #
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
4-Aminopyridine	Non-selective KV channel blocker	[504-24-5]

Search CenterWatch for drugs/clinical trials and news about KCNS1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KCNS1 gene:

NM_002251.3

Unigene Cluster for KCNS1:

Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1

Hs.117780 [show with all ESTs]

Unigene Representative Sequence: AF043473

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000306117(uc002xnc.3 uc002xnd.3) ENST00000537075

miRNA Products:		OriGene 3'-UTR Clone: KCNS1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNS1
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNS1 (see all 9):
		hsa-miR-1266 hsa-miR-3130-3p hsa-miR-624 hsa-miR-1205 hsa-miR-3907 hsa-miR-4298 hsa-miR-1302 hsa-miR-149

		SwitchGear 3'UTR luciferase reporter plasmid: KCNS1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNS1 (see all 7) OriGene shRNA RFP: KCNS1 OriGene siRNA: KCNS1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNS1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNS1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNS1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KCNS1 (NM_002251)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNS1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNS1

Additional cDNA sequence:

AF043473.2 AK289735.1 BC075033.2 BC075034.2 BC132957.1 BC132959.1 BC144234.1

3 DOTS entries:

DT.212165 DT.120821695 DT.120821696

24/29 AceView cDNA sequences (see all 29):

BC075034 BC075033 H43697 NM_002251 H51391 BF914751 AF043473 H49525

BF914749 T08732 H18164 H20175 AA788916 H18119 BF037198 H49759

CD614379 CD614377 H85454 BE819000 H43171 R88616 H20365 H51390

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for KCNS1 About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5
SP1:
SP2:			-

ECgene alternative splicing isoforms for KCNS1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCNS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATCAGTGAA

About this image

KCNS1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

HyStem+TGF?3+GDF5-induced SM30 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+BMP4-induced SM30 cells (HyStem+BMP4 inductio...)

Adipose, Bone, Cartilage

TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced E15 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KCNS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNS1

SOURCE GeneReport for Unigene cluster: Hs.117780

UniProtKB/Swiss-Prot: KCNS1_HUMAN, Q96KK3

Tissue specificity: Detected in all tissues tested with the exception of skeletal muscle. Highly expressed in adult and

fetal brain, fetal kidney and lung, and adult prostate and testis

SABiosciences Expression via Pathway-Focused PCR Array including KCNS1:

Neuronal Ion Channels in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNS1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNS1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KCNS1 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KCNS1¹	potassium voltage-gated channel, delayed-rectifier, more	74.89(n) 72.47(a)		770173 XM_001232666.2 XP_001232667.1
lizard (Anolis carolinensis)	Reptilia	KCNS1⁶	--	71(a)	1 ↔ 1	4(143384323-143399328)
zebrafish (Danio rerio)	Actinopterygii	LOC100148290¹	potassium voltage-gated channel subfamily S member more	63.33(n) 65.39(a)		100148290 XM_001922158.1 XP_001922193.1
honey bee (Apis mellifera)	Insecta	--	--	25(a)	possible ortholog	Group13.15(957-3745)
worm (Caenorhabditis elegans)	Secernentea	F44A2.2³	potassium channel protein	32(a) (best of 2)		V(9320822-9321939) --

ENSEMBL Gene Tree for KCNS1 (if available)
TreeFam Gene Tree for KCNS1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KCNS1 gene

KCNG3² KCNF1² KCNB2² KCNV1² KCNG2² KCNS2² KCNS3² KCNB1²

KCNV2² KCNG4² KCNG1²

18/24 SIMAP similar genes for KCNS1 using alignment to 2 protein entries: KCNS1_HUMAN (see all proteins) (see all similar genes):

KCNS2 KCNS3 KCNB1 KCNB2 KCNG1 KCNV2

KCNA7 KCNG4 KCNG2 KCNG3 KCNV1 KCNA10

KCNF1 KCNA1 KCNA2 KCNA3 KCNC1 KCNC2

KCNS1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112243918^1,2		--	43720474(+)	`ACCACC/AAACTA`	1	--	ds500¹		1		CSA	2
rs190875548^1,2		--	43720558(+)	`TTTCTA/GGCCTC`	1	--	ds500¹		0	--	--	--	--
rs114633002^1,2	F,	--	43720646(+)	`CTAATA/GTATCT`	1	--	ds500¹		1		WA	118
rs6073639^1,2	C,F,	--	43720812(+)	`CTGGCA/GCAACC`	1	--	ds500¹		10		NA WA EA	488
rs183354808^1,2		--	43720861(+)	`TGTGGA/GTTCCA`	1	--	ds500¹		0	--	--	--	--
rs149167220^1,2		--	43720897(+)	`CTCCAA/GTCACT`	1	--	ds500¹		0	--	--	--	--
rs143323393^1,2		--	43720907(+)	`TCAGAC/TAGCAT`	1	--	ds500¹		0	--	--	--	--
rs118092179^1,2	F,	--	43720948(+)	`CACGTC/TCTGGG`	1	--	ds500¹		1		NA	120
rs186944434^1,2		--	43721005(+)	`GGGAGC/TGAGTT`	1	--	ut3¹		0	--	--	--	--
rs191364989^1,2		--	43721263(+)	`GTGTGA/GTGAAT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KCNS1 (43720950 - 43729753 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KCNS1: --
Human Gene Mutation Database (HGMD): KCNS1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNS1

DNA2.0 Custom Variant and Variant Library Synthesis for KCNS1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KCNS1 for disorders           About GeneDecksing

OMIM gene information: 602905    OMIM disorders: --

5 diseases for KCNS1:    About MalaCards

chronic pain fainting pharyngitis prostatitis

neuronitis

Human Genome Epidemiology (HuGE) Navigator: KCNS1 (1 document)

Export disorders for KCNS1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KCNS1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KCNS1)

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International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)^{1, 3} Gutman G.A....Wang X. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Electrically silent potassium channel subunits from human lens epithelium. (PubMed id 10484328)^{1, 2} Shepard A.R. and Rae J.L. (1999)
New modulatory alpha subunits for mammalian Shab K+ channels. (PubMed id 9305895)^{1, 3} Salinas M....Lazdunski M. (1997)
Multiple chronic pain states are associated with a co mmon amino acid-changing allele in KCNS1. (PubMed id 20724292)¹ Costigan M....Woolf C.J. (2010)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20. (PubMed id 11549316)¹ Fossey S.C....Bowden D.W. (2001)
Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells. (PubMed id 16815889)⁹ Fantozzi I....Yuan J.X. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3787	HGNC: 6300	AceView: KCNS1	Ensembl:ENSG00000124134	euGenes: HUgn3787
ECgene: KCNS1	H-InvDB: KCNS1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for KCNS1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KCNS1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KCNS1 gene:
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