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Aliases for KCNRG Gene

Aliases for KCNRG Gene

  • Potassium Channel Regulator 2 3 4
  • Putative Potassium Channel Regulatory Protein 3
  • Potassium Channel Regulatory Protein 3
  • Protein CLLD4 4
  • DLTET 3
  • CLLD4 4

External Ids for KCNRG Gene

Previous GeneCards Identifiers for KCNRG Gene

  • GC13P044577
  • GC13P049526
  • GC13P048387
  • GC13P049470
  • GC13P049487
  • GC13P050589
  • GC13P031384

Summaries for KCNRG Gene

Entrez Gene Summary for KCNRG Gene

  • This gene encodes a protein which regulates the activity of voltage-gated potassium channels. This gene is on chromosome 13 and overlaps the gene for tripartite motif containing 13 on the same strand. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for KCNRG Gene

KCNRG (Potassium Channel Regulator) is a Protein Coding gene. Diseases associated with KCNRG include autoimmune polyendocrine syndrome type 1. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include identical protein binding. An important paralog of this gene is KCTD11.

UniProtKB/Swiss-Prot for KCNRG Gene

  • Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes.

Gene Wiki entry for KCNRG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNRG Gene

Genomics for KCNRG Gene

Regulatory Elements for KCNRG Gene

Genomic Location for KCNRG Gene

Start:
50,015,254 bp from pter
End:
50,020,922 bp from pter
Size:
5,669 bases
Orientation:
Plus strand

Genomic View for KCNRG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNRG Gene

Proteins for KCNRG Gene

  • Protein details for KCNRG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5I3-KCNRG_HUMAN
    Recommended name:
    Potassium channel regulatory protein
    Protein Accession:
    Q8N5I3
    Secondary Accessions:
    • A2A2X9
    • Q0P6D0
    • Q8IU75
    • Q8N3Q9

    Protein attributes for KCNRG Gene

    Size:
    272 amino acids
    Molecular mass:
    31048 Da
    Quaternary structure:
    • Can form homooligomers. Interacts with KCNA1 (via cytoplasmic N-terminal domain) and KCNA4.

    Alternative splice isoforms for KCNRG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNRG Gene

Proteomics data for KCNRG Gene at MOPED

Post-translational modifications for KCNRG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNRG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNRG Gene

Domains for KCNRG Gene

Protein Domains for KCNRG Gene

Suggested Antigen Peptide Sequences for KCNRG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5I3

UniProtKB/Swiss-Prot:

KCNRG_HUMAN :
  • Q8N5I3
Domain:
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCNRG: view

No data available for Gene Families for KCNRG Gene

Function for KCNRG Gene

Molecular function for KCNRG Gene

UniProtKB/Swiss-Prot Function: Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes.

Gene Ontology (GO) - Molecular Function for KCNRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19968958
GO:0042802 identical protein binding IPI 16189514
genes like me logo Genes that share ontologies with KCNRG: view

Phenotypes for KCNRG Gene

GenomeRNAi human phenotypes for KCNRG:
genes like me logo Genes that share phenotypes with KCNRG: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNRG

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNRG Gene

Localization for KCNRG Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNRG Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNRG Gene COMPARTMENTS Subcellular localization image for KCNRG gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 2
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 19968958
genes like me logo Genes that share ontologies with KCNRG: view

Pathways for KCNRG Gene

genes like me logo Genes that share pathways with KCNRG: view

Gene Ontology (GO) - Biological Process for KCNRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
GO:1902260 negative regulation of delayed rectifier potassium channel activity IDA 19968958
genes like me logo Genes that share ontologies with KCNRG: view

Transcripts for KCNRG Gene

mRNA/cDNA for KCNRG Gene

Unigene Clusters for KCNRG Gene

Potassium channel regulator:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNRG

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNRG Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2:
SP3: -
SP4: -

Relevant External Links for KCNRG Gene

GeneLoc Exon Structure for
KCNRG
ECgene alternative splicing isoforms for
KCNRG

Expression for KCNRG Gene

mRNA expression in normal human tissues for KCNRG Gene

mRNA differential expression in normal tissues according to GTEx for KCNRG Gene

This gene is overexpressed in Fallopian Tube (8.7) and Cervix - Endocervix (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNRG Gene

SOURCE GeneReport for Unigene cluster for KCNRG Gene Hs.660161

mRNA Expression by UniProt/SwissProt for KCNRG Gene

Q8N5I3-KCNRG_HUMAN
Tissue specificity: Ubiquitous in normal tissues and expressed in some tumor tissues.
genes like me logo Genes that share expressions with KCNRG: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KCNRG Gene

Orthologs for KCNRG Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNRG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNRG 35
  • 99.63 (n)
  • 99.63 (a)
KCNRG 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNRG 35
  • 87.22 (n)
  • 84.59 (a)
KCNRG 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNRG 35
  • 89.18 (n)
  • 87.45 (a)
KCNRG 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnrg 35
  • 83.14 (n)
  • 74.9 (a)
Kcnrg 16
Kcnrg 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNRG 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNRG 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnrg 35
  • 81.57 (n)
  • 76.89 (a)
chicken
(Gallus gallus)
Aves KCNRG 35
  • 62.61 (n)
  • 59.04 (a)
KCNRG 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNRG 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnrg 35
  • 60.66 (n)
  • 58.62 (a)
zebrafish
(Danio rerio)
Actinopterygii kctd12.1 36
  • 22 (a)
ManyToMany
Species with no ortholog for KCNRG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNRG Gene

ENSEMBL:
Gene Tree for KCNRG (if available)
TreeFam:
Gene Tree for KCNRG (if available)

Paralogs for KCNRG Gene

Paralogs for KCNRG Gene

genes like me logo Genes that share paralogs with KCNRG: view

Variants for KCNRG Gene

Relevant External Links for KCNRG Gene

HapMap Linkage Disequilibrium report
KCNRG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for KCNRG Gene

Disorders for KCNRG Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for KCNRG Gene including...

Search for KCNRG Gene in MalaCards »

(1) University of Copenhagen DISEASES for KCNRG Gene

genes like me logo Genes that share disorders with KCNRG: view

No data available for UniProtKB/Swiss-Prot for KCNRG Gene

Publications for KCNRG Gene

  1. A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3. (PMID: 12650944) Ivanov D.V. … Baranova A.V. (FEBS Lett. 2003) 3 4 23
  2. Potassium channel regulator KCNRG regulates surface expression of Shaker-type potassium channels. (PMID: 19968958) Usman H. … Mathew M.K. (Biochem. Biophys. Res. Commun. 2010) 3 4
  3. Pro-apoptotic and antiproliferative activity of human KCNRG, a putative tumor suppressor in 13q14 region. (PMID: 20237900) Birerdinc A. … Baranova A. (Tumour Biol. 2010) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for KCNRG Gene

Sources for KCNRG Gene

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