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Aliases for KCNRG Gene

Aliases for KCNRG Gene

  • Potassium Channel Regulator 2 3 4 5
  • Putative Potassium Channel Regulatory Protein 3
  • Protein CLLD4 4
  • DLTET 3
  • CLLD4 4

External Ids for KCNRG Gene

Previous GeneCards Identifiers for KCNRG Gene

  • GC13P044577
  • GC13P049526
  • GC13P048387
  • GC13P049470
  • GC13P049487
  • GC13P050589
  • GC13P031384

Summaries for KCNRG Gene

Entrez Gene Summary for KCNRG Gene

  • This gene encodes a protein which regulates the activity of voltage-gated potassium channels. This gene is on chromosome 13 and overlaps the gene for tripartite motif containing 13 on the same strand. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for KCNRG Gene

KCNRG (Potassium Channel Regulator) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. GO annotations related to this gene include identical protein binding. An important paralog of this gene is KCTD11.

UniProtKB/Swiss-Prot for KCNRG Gene

  • Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes.

Gene Wiki entry for KCNRG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNRG Gene

Genomics for KCNRG Gene

Regulatory Elements for KCNRG Gene

Enhancers for KCNRG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCNRG on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNRG Gene

50,015,254 bp from pter
50,020,922 bp from pter
5,669 bases
Plus strand

Genomic View for KCNRG Gene

Genes around KCNRG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNRG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNRG Gene

Proteins for KCNRG Gene

  • Protein details for KCNRG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium channel regulatory protein
    Protein Accession:
    Secondary Accessions:
    • A2A2X9
    • Q0P6D0
    • Q8IU75
    • Q8N3Q9

    Protein attributes for KCNRG Gene

    272 amino acids
    Molecular mass:
    31048 Da
    Quaternary structure:
    • Can form homooligomers. Interacts with KCNA1 (via cytoplasmic N-terminal domain) and KCNA4.

    Alternative splice isoforms for KCNRG Gene


neXtProt entry for KCNRG Gene

Proteomics data for KCNRG Gene at MOPED

Post-translational modifications for KCNRG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNRG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNRG Gene

Domains & Families for KCNRG Gene

Protein Domains for KCNRG Gene

Suggested Antigen Peptide Sequences for KCNRG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with KCNRG: view

No data available for Gene Families for KCNRG Gene

Function for KCNRG Gene

Molecular function for KCNRG Gene

UniProtKB/Swiss-Prot Function:
Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes.
genes like me logo Genes that share phenotypes with KCNRG: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNRG Gene

Localization for KCNRG Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNRG Gene

Endoplasmic reticulum.

Subcellular locations from

Jensen Localization Image for KCNRG Gene COMPARTMENTS Subcellular localization image for KCNRG gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 2
cytosol 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for KCNRG Gene

Pathways & Interactions for KCNRG Gene

genes like me logo Genes that share pathways with KCNRG: view

Gene Ontology (GO) - Biological Process for KCNRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1902260 negative regulation of delayed rectifier potassium channel activity IDA 19968958
genes like me logo Genes that share ontologies with KCNRG: view

No data available for SIGNOR curated interactions for KCNRG Gene

Drugs & Compounds for KCNRG Gene

No Compound Related Data Available

Transcripts for KCNRG Gene

mRNA/cDNA for KCNRG Gene

Unigene Clusters for KCNRG Gene

Potassium channel regulator:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNRG Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP3: -
SP4: -

Relevant External Links for KCNRG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCNRG Gene

mRNA expression in normal human tissues for KCNRG Gene

mRNA differential expression in normal tissues according to GTEx for KCNRG Gene

This gene is overexpressed in Fallopian Tube (x8.7) and Cervix - Endocervix (x6.7).

Protein differential expression in normal tissues from HIPED for KCNRG Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNRG Gene

SOURCE GeneReport for Unigene cluster for KCNRG Gene Hs.660161

mRNA Expression by UniProt/SwissProt for KCNRG Gene

Tissue specificity: Ubiquitous in normal tissues and expressed in some tumor tissues.
genes like me logo Genes that share expression patterns with KCNRG: view

Protein tissue co-expression partners for KCNRG Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KCNRG Gene

Orthologs for KCNRG Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNRG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCNRG 35
  • 87.22 (n)
  • 84.59 (a)
  • 84 (a)
(Canis familiaris)
Mammalia KCNRG 35
  • 89.18 (n)
  • 87.45 (a)
  • 87 (a)
(Mus musculus)
Mammalia Kcnrg 35
  • 83.14 (n)
  • 74.9 (a)
Kcnrg 16
Kcnrg 36
  • 75 (a)
(Pan troglodytes)
Mammalia KCNRG 35
  • 99.63 (n)
  • 99.63 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Kcnrg 35
  • 81.57 (n)
  • 76.89 (a)
(Monodelphis domestica)
Mammalia KCNRG 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia KCNRG 36
  • 67 (a)
(Gallus gallus)
Aves KCNRG 35
  • 62.61 (n)
  • 59.04 (a)
  • 58 (a)
(Anolis carolinensis)
Reptilia KCNRG 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnrg 35
  • 60.66 (n)
  • 58.62 (a)
(Danio rerio)
Actinopterygii kctd12.1 36
  • 22 (a)
Species with no ortholog for KCNRG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNRG Gene

Gene Tree for KCNRG (if available)
Gene Tree for KCNRG (if available)

Paralogs for KCNRG Gene

Paralogs for KCNRG Gene

genes like me logo Genes that share paralogs with KCNRG: view

Variants for KCNRG Gene

Variation tolerance for KCNRG Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for KCNRG Gene

Disorders for KCNRG Gene

Relevant External Links for KCNRG

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KCNRG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNRG Gene

Publications for KCNRG Gene

  1. A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3. (PMID: 12650944) Ivanov D.V. … Baranova A.V. (FEBS Lett. 2003) 3 4 23 67
  2. Pro-apoptotic and antiproliferative activity of human KCNRG, a putative tumor suppressor in 13q14 region. (PMID: 20237900) Birerdinc A. … Baranova A. (Tumour Biol. 2010) 3 23
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Potassium channel regulator KCNRG regulates surface expression of Shaker-type potassium channels. (PMID: 19968958) Usman H. … Mathew M.K. (Biochem. Biophys. Res. Commun. 2010) 3
  5. Pulmonary autoimmunity as a feature of autoimmune polyendocrine syndrome type 1 and identification of KCNRG as a bronchial autoantigen. (PMID: 19251657) Alimohammadi M. … Carel J.C. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3

Products for KCNRG Gene

Sources for KCNRG Gene