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KCNRG Gene

protein-coding   GIFtS: 45
GCID: GC13P050589

Potassium Channel Regulator

  See KCNRG-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Channel Regulator1 2 3
DLTET2
Potassium Channel Regulatory Protein2
Putative Potassium Channel Regulatory Protein2
CLLD43
Protein CLLD43

External Ids:    HGNC: 188931   Entrez Gene: 2835182   Ensembl: ENSG000001985537   OMIM: 6079475   UniProtKB: Q8N5I33   

Export aliases for KCNRG gene to outside databases

Previous GC identifers: GC13P044577 GC13P049526 GC13P048387 GC13P049470 GC13P049487 GC13P031384


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNRG Gene:
This gene encodes a protein which regulates the activity of voltage-gated potassium channels. This gene is on
chromosome 13 and overlaps the gene for tripartite motif containing 13 on the same strand. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Feb 2012)

GeneCards Summary for KCNRG Gene:
KCNRG (potassium channel regulator) is a protein-coding gene. Diseases associated with KCNRG include autoimmune polyendocrine syndrome type 1. GO annotations related to this gene include identical protein binding. An important paralog of this gene is KCTD1.

UniProtKB/Swiss-Prot: KCNRG_HUMAN, Q8N5I3
Function: Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of
channels in endomembranes

Gene Wiki entry for KCNRG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNRG gene promoter:
         ISGF-3   SREBP-1c   STAT5A   GATA-1   SREBP-1b   SREBP-1a   Ik-2   HOXA5   PPAR-gamma2   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KCNRG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNRG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.2   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14.11

KCNRG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNRG gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P050589:  view genomic region     (about GC identifiers)

Start:
50,589,390 bp from pter      End:
50,595,058 bp from pter
Size:
5,669 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCNRG_HUMAN, Q8N5I3 (See protein sequence)
Recommended Name: Potassium channel regulatory protein  
Size: 272 amino acids; 31048 Da
Secondary accessions: A2A2X9 Q0P6D0 Q8IU75 Q8N3Q9
Alternative splicing: 2 isoforms:  Q8N5I3-1   Q8N5I3-2   

Explore the universe of human proteins at neXtProt for KCNRG: NX_Q8N5I3

Explore proteomics data for KCNRG at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KCNRG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_775876.1  NP_955751.1  

    ENSEMBL proteins: 
     ENSP00000353661   ENSP00000324191  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003131 T1-type_BTB

    Graphical View of Domain Structure for InterPro Entry Q8N5I3

    ProtoNet protein and cluster: Q8N5I3

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: KCNRG_HUMAN, Q8N5I3
    Similarity: Contains 1 BTB (POZ) domain


    Find genes that share domains with KCNRG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNRG_HUMAN, Q8N5I3
    Function: Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of
    channels in endomembranes

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042802identical protein binding IPI16189514
         
    Find genes that share ontologies with KCNRG           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KCNRG:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNRG
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCNRG_HUMAN, Q8N5I3: Endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion2
    cytosol1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--

    Find genes that share ontologies with KCNRG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNRG About    
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37
    Cellular Effects of Sildenafil0.46
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    4Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    MODY (Maturity-Onset Diabetes of Young)0.41

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KCNRG (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNRG
    Interactions:

        Search GeneGlobe Interaction Network for KCNRG

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for KCNRG (Q8N5I31, 2, 3 ENSP000003241914) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNKO759092, 3, ENSP000003745294MINT-66721 I2D: score=4 STRING: ENSP00000374529
    FXR2P511162, 3, ENSP000002501134MINT-67215 I2D: score=4 STRING: ENSP00000250113
    KCNRGQ8N5I31, 2EBI-745755,EBI-745755 MINT-66769
    ROBO2Q9HCK42, 3, ENSP000004171644MINT-8275204 I2D: score=1 STRING: ENSP00000417164
    ARHGDIAP525652, 3, ENSP000002693214MINT-8275193 I2D: score=1 STRING: ENSP00000269321
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051260protein homooligomerization IEA--

    Find genes that share ontologies with KCNRG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KCNRG



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCNRG gene (2 alternative transcripts): 
    NM_173605.1  NM_199464.2  

    Unigene Cluster for KCNRG:

    Potassium channel regulator
    Hs.660161  [show with all ESTs]
    Unigene Representative Sequence: AY169387
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360473(uc001vdt.3) ENST00000312942(uc001vdu.3)
    miRNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNRG
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat KCNRG
      QuantiFast Probe-based Assays in human, mouse, rat KCNRG

    Additional mRNA sequence: 

    AF086244.1 AK313401.1 AY129653.1 AY129654.1 AY169387.1 AY169388.1 AY190921.1 AY190922.1 
    BC020887.1 BC032343.1 

    6 DOTS entries:

    DT.97823488  DT.302847  DT.120775007  DT.100778752  DT.120774940  DT.102843617 

    Selected AceView cDNA sequences (see all 229):

    AI675587 AU134155 W68829 BF513203 AF241850 AF220127 AA447003 AI523269 
    BU155962 BM711217 AA810526 BE542685 CR612306 BM977870 AY190921 AA992127 
    AI217138 AL526890 BM666198 AY169388 AA456865 BU607743 AU117766 AA443356 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KCNRG    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
    SP1:                                                
    SP2:                                                
    SP3:                                      -         
    SP4:              -                                 


    ECgene alternative splicing isoforms for KCNRG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNRG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KCNRG Expression
    About this image

    KCNRG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNRG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.660161

    UniProtKB/Swiss-Prot: KCNRG_HUMAN, Q8N5I3
    Tissue specificity: Ubiquitous in normal tissues and expressed in some tumor tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KCNRG gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnrg1 , 5 potassium channel regulator1, 5 83.14(n)1
    74.9(a)1
      14 (33.16 cM)5
    3284241  NM_001039105.31  NP_001034194.11 
     616074825 
    chicken
    (Gallus gallus)
    Aves KCNRG1 potassium channel regulator 62.61(n)
    59.04(a)
      418873  XM_417068.3  XP_417068.2 
    lizard
    (Anolis carolinensis)
    Reptilia KCNRG6
    potassium channel regulator
    55(a)
    1 ↔ 1
    1(137613371-137615522)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kcnrg1 potassium channel regulator 60.66(n)
    58.62(a)
      394457  NM_203532.1  NP_988863.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kctd12.16
    potassium channel tetramerisation domain containin...
    22(a)
    many ↔ many
    9(22877260-22879128) ENSDARG00000069843


    ENSEMBL Gene Tree for KCNRG (if available)
    TreeFam Gene Tree for KCNRG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNRG gene
    KCTD12  KCTD82  KCTD152  KCTD162  KCTD42  KCTD112  KCTD122  KCTD212  
    KCTD62  KCTD142  

    Find genes that share paralogs with KCNRG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607947    OMIM disorders: --

    1 disease for KCNRG:    
    About MalaCards
    autoimmune polyendocrine syndrome type 1

    1 disease from the University of Copenhagen DISEASES database for KCNRG:
    Autoimmune polyendocrine syndrome type 1

    Find genes that share disorders with KCNRG           About GenesLikeMe


    Export disorders for KCNRG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNRG gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with KCNRG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3. (PubMed id 12650944)1, 2, 9 Ivanov D.V.... Baranova A.V. (FEBS Lett. 2003)
    2. Potassium channel regulator KCNRG regulates surface expression of Shaker-type potassium channels. (PubMed id 19968958)1, 2 Usman H. and Mathew M.K. (Biochem. Biophys. Res. Commun. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Pro-apoptotic and antiproliferative activity of human KCNRG, a putative tumor suppressor in 13q14 region. (PubMed id 20237900)1, 9 Birerdinc A....Baranova A. (Tumour Biol. 2010)
    5. Shifted Transversal Design smart-pooling for high coverage interactome mapping. (PubMed id 19447967)1 Xin X....Thierry-Mieg N. (Genome Res. 2009)
    6. Pulmonary autoimmunity as a feature of autoimmune polyendocrine syndrome type 1 and identification of KCNRG as a bronchial autoantigen. (PubMed id 19251657)1 Alimohammadi M....Carel J.C. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    8. Human RFP2 gene promoter: unique structure and unusual strength. (PubMed id 16499869)1 Skoblov M....Baranova A. (Biochem. Biophys. Res. Commun. 2006)
    9. Genetic and expression analysis of the KCNRG gene in hepatocellular carcinomas. (PubMed id 16819283)1 Cho Y.G....Park W.S. (amp 2006)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 283518 HGNC: 18893 AceView: RFP2 Ensembl:ENSG00000198553 euGenes: HUgn283518
    ECgene: KCNRG H-InvDB: KCNRG

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCNRG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCNRG gene:
    Search GeneIP for patents involving KCNRG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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