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Aliases for KCNQ5 Gene

Aliases for KCNQ5 Gene

  • Potassium Channel, Voltage Gated KQT-Like Subfamily Q, Member 5 2 3
  • Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 5 2 3
  • Voltage-Gated Potassium Channel Subunit Kv7.5 3 4
  • Potassium Channel Subunit Alpha KvLQT5 3 4
  • KQT-Like 5 3 4
  • Potassium Voltage-Gated Channel Subfamily KQT Member 5 3
  • Potassium Channel Protein 3
  • Kv7.5 3

External Ids for KCNQ5 Gene

Summaries for KCNQ5 Gene

Entrez Gene Summary for KCNQ5 Gene

  • This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

GeneCards Summary for KCNQ5 Gene

KCNQ5 (Potassium Channel, Voltage Gated KQT-Like Subfamily Q, Member 5) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Circadian entrainment. GO annotations related to this gene include delayed rectifier potassium channel activity and inward rectifier potassium channel activity. An important paralog of this gene is KCNQ4.

UniProtKB/Swiss-Prot for KCNQ5 Gene

  • Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors

Gene Wiki entry for KCNQ5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNQ5 Gene

Genomics for KCNQ5 Gene

Genomic Location for KCNQ5 Gene

Start:
72,621,792 bp from pter
End:
73,198,851 bp from pter
Size:
577,060 bases
Orientation:
Plus strand

Genomic View for KCNQ5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNQ5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNQ5 Gene

Regulatory Elements for KCNQ5 Gene

Proteins for KCNQ5 Gene

  • Protein details for KCNQ5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR82-KCNQ5_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily KQT member 5
    Protein Accession:
    Q9NR82
    Secondary Accessions:
    • A6NKT6
    • A6PVT6
    • A8MSQ5
    • B4DS33
    • B5MC83
    • B7ZL37
    • F5GZV0
    • Q17RE1
    • Q5VVP3
    • Q86W40
    • Q9NRN0
    • Q9NYA6

    Protein attributes for KCNQ5 Gene

    Size:
    932 amino acids
    Molecular mass:
    102179 Da
    Quaternary structure:
    • Heteromultimer with KCNQ3
    SequenceCaution:
    • Sequence=BAG61495.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for KCNQ5 Gene

neXtProt entry for KCNQ5 Gene

Proteomics data for KCNQ5 Gene at MOPED

Post-translational modifications for KCNQ5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KCNQ5 Gene

Domains for KCNQ5 Gene

Gene Families for KCNQ5 Gene

HGNC:
  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels
IUPHAR :

UniProtKB/Swiss-Prot:

KCNQ5_HUMAN
Domain:
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.:
    • Q9NR82
Family:
  • Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily.:
    • Q9NR82
genes like me logo Genes that share domains with KCNQ5: view

Function for KCNQ5 Gene

Molecular function for KCNQ5 Gene

UniProtKB/Swiss-Prot Function: Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors

Gene Ontology (GO) - Molecular Function for KCNQ5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005242 inward rectifier potassium channel activity TAS 10787416
GO:0005249 voltage-gated potassium channel activity --
GO:0005251 delayed rectifier potassium channel activity IBA --
genes like me logo Genes that share ontologies with KCNQ5: view

Phenotypes for KCNQ5 Gene

MGI mutant phenotypes for KCNQ5:
inferred from 1 alleles
GenomeRNAi human phenotypes for KCNQ5:
genes like me logo Genes that share phenotypes with KCNQ5: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNQ5 Gene

Localization for KCNQ5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNQ5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNQ5 Gene COMPARTMENTS Subcellular localization image for KCNQ5 gene
Compartment Confidence
plasma membrane 4
nucleus 2

Gene Ontology (GO) - Cellular Components for KCNQ5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with KCNQ5: view

Pathways for KCNQ5 Gene

genes like me logo Genes that share pathways with KCNQ5: view

Pathways by source for KCNQ5 Gene

1 Qiagen pathway for KCNQ5 Gene
1 PharmGKB pathway for KCNQ5 Gene
1 KEGG pathway for KCNQ5 Gene

Gene Ontology (GO) - Biological Process for KCNQ5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly NAS 10787416
GO:0006811 ion transport --
GO:0006813 potassium ion transport --
GO:0007268 synaptic transmission TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNQ5: view

Compounds for KCNQ5 Gene

(1) HMDB Compounds for KCNQ5 Gene

Compound Synonyms Cas Number PubMed IDs
Potassium
  • K+
7440-09-7

(1) Drugbank Compounds for KCNQ5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Ezogabine
  • D-23129
150812-12-7 target

(7) IUPHAR Ligand for KCNQ5 Gene

Ligand Type Action Affinity Pubmed IDs
BMS204352 Activator None 5.6
zinc pyrithione Activator None 5
retigabine Activator None 5
linopirdine Pore Blocker None 4.5
XE991 Pore Blocker None 4.2
tetraethylammonium Inhibitor None
N-(S)-MPEPAamide Activator None

(3) Novoseek inferred chemical compound relationships for KCNQ5 Gene

Compound -log(P) Hits PubMed IDs
linopirdine 90.8 1
retigabine 86.7 2
potassium 60.8 6
genes like me logo Genes that share compounds with KCNQ5: view

Transcripts for KCNQ5 Gene

Unigene Clusters for KCNQ5 Gene

Potassium voltage-gated channel, KQT-like subfamily, member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNQ5 Gene

No ASD Table

Relevant External Links for KCNQ5 Gene

GeneLoc Exon Structure for
KCNQ5
ECgene alternative splicing isoforms for
KCNQ5

Expression for KCNQ5 Gene

mRNA expression in normal human tissues for KCNQ5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNQ5 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (8.2), Muscle - Skeletal (6.2), Brain - Anterior cingulate cortex (BA24) (5.9), Brain - Nucleus accumbens (basal ganglia) (5.5), Brain - Cortex (5.0), Brain - Putamen (basal ganglia) (4.5), and Brain - Caudate (basal ganglia) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNQ5 Gene

SOURCE GeneReport for Unigene cluster for KCNQ5 Gene Hs.445324

mRNA Expression by UniProt/SwissProt for KCNQ5 Gene

Q9NR82-KCNQ5_HUMAN
Tissue specificity: Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus
genes like me logo Genes that share expressions with KCNQ5: view

Orthologs for KCNQ5 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNQ5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNQ5 36
  • 99.65 (n)
  • 99.79 (a)
KCNQ5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNQ5 36
  • 83.55 (n)
  • 88.5 (a)
KCNQ5 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNQ5 36
  • 95.13 (n)
  • 97.79 (a)
KCNQ5 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnq5 36
  • 90.34 (n)
  • 95.49 (a)
Kcnq5 16
Kcnq5 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNQ5 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNQ5 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnq5 36
  • 90.35 (n)
  • 95.16 (a)
chicken
(Gallus gallus)
Aves KCNQ5 36
  • 77.75 (n)
  • 82.47 (a)
KCNQ5 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNQ5 37
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnq5 36
  • 74.78 (n)
  • 78.89 (a)
zebrafish
(Danio rerio)
Actinopterygii kcnq5a 36
  • 64.46 (n)
  • 68.69 (a)
kcnq5a 37
  • 60 (a)
OneToMany
kcnq5b 37
  • 58 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kqt-1 36
  • 53.87 (n)
  • 48.15 (a)
kqt-2 37
  • 22 (a)
OneToMany
kqt-2 38
  • 30 (a)
kqt-1 38
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 57 (a)
OneToMany
Species with no ortholog for KCNQ5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNQ5 Gene

ENSEMBL:
Gene Tree for KCNQ5 (if available)
TreeFam:
Gene Tree for KCNQ5 (if available)

Paralogs for KCNQ5 Gene

Paralogs for KCNQ5 Gene

Selected SIMAP similar genes for KCNQ5 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with KCNQ5: view

Variants for KCNQ5 Gene

Sequence variations from dbSNP and Humsavar for KCNQ5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs719830 -- 72,722,245(+) GGCAT(A/G)CTGTC intron-variant
rs867262 -- 72,868,456(-) GTTAA(C/T)AGGCC intron-variant
rs867520 -- 72,620,858(+) TGAGA(G/T)TTAAA upstream-variant-2KB
rs867521 -- 72,620,723(+) TGCTA(C/T)GTCTT upstream-variant-2KB
rs878523 -- 73,165,532(+) TGACC(A/G)CATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNQ5 Gene

Variant ID Type Subtype PubMed ID
nsv823730 CNV Loss 20364138
dgv1130e199 CNV Deletion 23128226
nsv463152 CNV Loss 19166990
dgv86n68 CNV Gain 17160897
nsv510037 CNV Loss 20534489
nsv886154 CNV Loss 21882294
nsv483033 CNV Gain 15286789
nsv830691 CNV Gain 17160897
nsv470834 CNV Loss 18288195
nsv886155 CNV Loss 21882294
nsv886156 CNV Loss 21882294
esv2220817 CNV Deletion 18987734
esv2732279 CNV Deletion 23290073
esv2732280 CNV Deletion 23290073
esv2732281 CNV Deletion 23290073
esv2666317 CNV Deletion 23128226
nsv349877 CNV Loss 16902084
esv2179651 CNV Deletion 18987734
esv2732282 CNV Deletion 23290073
esv2732283 CNV Deletion 23290073
nsv521957 CNV Gain 19592680
esv273861 CNV Insertion 20981092
esv2658922 CNV Deletion 23128226
nsv519218 CNV Gain 19592680
nsv525926 CNV Loss 19592680
esv1004012 CNV Deletion 20482838
nsv823732 CNV Loss 20364138

Relevant External Links for KCNQ5 Gene

HapMap Linkage Disequilibrium report
KCNQ5
Human Gene Mutation Database (HGMD)
KCNQ5

Disorders for KCNQ5 Gene

Relevant External Links for KCNQ5

Genetic Association Database (GAD)
KCNQ5
Human Genome Epidemiology (HuGE) Navigator
KCNQ5
genes like me logo Genes that share disorders with KCNQ5: view

No data available for UniProtKB/Swiss-Prot for KCNQ5 Gene

Publications for KCNQ5 Gene

  1. Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity. (PMID: 10787416) Lerche C. … Steinmeyer K. (J. Biol. Chem. 2000) 2 3 4 23
  2. KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents. (PMID: 10816588) Schroeder B.C. … Jentsch T.J. (J. Biol. Chem. 2000) 2 3 4 23
  3. Expression profile and characterisation of a truncated KCNQ5 splice variant. (PMID: 18457656) Yeung S.Y. … Greenwood I.A. (Biochem. Biophys. Res. Commun. 2008) 3 23
  4. Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells. (PMID: 11159685) Wickenden A.D. … Jegla T. (Br. J. Pharmacol. 2001) 3 4
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4

Products for KCNQ5 Gene

Sources for KCNQ5 Gene

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