KCNQ4 Gene
protein-coding GIFtS: 60
GCID: GC01P041249
|
|
potassium voltage-gated channel, KQT-like subfamily, member...
(Previous symbol: DFNA2)
| |
Aliases
for KCNQ4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 41 2 | | KV7.42 | | DFNA21 2 | | Potassium Channel KQT-Like 42 | | Potassium Channel Subunit Alpha KvLQT42 3 | | Potassium Voltage-Gated Channel Subfamily KQT Member 42 | | DFNA2A2 5 | | KQT-Like 43 | | Kv7.41 | | Voltage-Gated Potassium Channel Subunit Kv7.43 |
Export aliases for KCNQ4 gene to outside databasesPrevious GC identifers: GC01P041284 GC01P040253 GC01P040713 GC01P040662 GC01P040918 GC01P041022 GC01P039389 |
Summaries
for KCNQ4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KCNQ4:
The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation ofneuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel isinhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Theencoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association withthe protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2(DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoformshave been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: KCNQ4_HUMAN, P56696Function: Probably important in the regulation of neuronal excitability. May underlie a potassium current involved inregulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 andbepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors
Gene Wiki entry for KCNQ4
|
Genomic Views
for KCNQ4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_018912.1 NC_000001.10 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCNQ4 gene promoter:
E2F-4 E2F-3a E2F-5 p53 E2F-2 Tal-1beta E2F E2F-1 GR-alpha ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCNQ4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNQ4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p34 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34KCNQ4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P041249: view genomic region
(about GC identifiers)
Start:
|
41,249,684 bp from pter |
End:
|
41,306,124 bp from pter |
Size:
|
56,441 bases |
Orientation:
|
plus strand |
|
Proteins
for KCNQ4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KCNQ4_HUMAN, P56696 (See
protein sequence)Recommended Name: Potassium voltage-gated channel subfamily KQT member 4 Size: 695 amino acids; 77101 Da
Subunit: Homotetramer. May form heteromultimers with KCNQ3
Subcellular location: Basal cell membrane; Multi-pass membrane protein. Note=Situated at the basal membrane of cochlearouter hair cells (By similarity)
Miscellaneous: Mutagenesis experiments were carried out by expressing in Xenopus oocytes KCNQ4 mutants eitherindividually (homomultimers) or in combination with wild-type KCNQ4 (mut/wt homomultimers) in a ratio of 1:1, to mimicthe situation in a heterozygous DFNA2 patient
2 PDB 3D structures from  and Proteopedia  for KCNQ4:2OVC (3D)
4GOW (3D)
Secondary accessions: O96025Alternative splicing: 2 isoforms: P56696-1 P56696-2 Explore the universe of human proteins at neXtProt for KCNQ4: NX_P56696
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P56696
KCNQ4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_004691.2 NP_751895.1
ENSEMBL proteins: ENSP00000262916 ENSP00000423756 ENSP00000406735 Reactome Protein details: P56696
Human Recombinant Protein Products for KCNQ4:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
KCNQ4 for ontologies About GeneDecksing
KCNQ4 Antibody Products:
Assay Products for KCNQ4: |
Protein
Domains /
Families
for KCNQ4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCNQ4 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P56696ProtoNet protein and cluster: P56696 1 Blocks protein family: IPB013821 KCNQ voltage-gated potassium channel
UniProtKB/Swiss-Prot: KCNQ4_HUMAN, P56696Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged aminoacids at every third position (By similarity)Domain: The A-domain tail carries the major determinants of channel assembly specificity. Its coiled-coil region isFour-strandedSimilarity: Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.4/KCNQ4 sub-subfamily |
Function
for KCNQ4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: KCNQ4_HUMAN, P56696Function: Probably important in the regulation of neuronal excitability. May underlie a potassium current involved inregulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 andbepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors Genatlas biochemistry entry for KCNQ4:potassium voltage-gated channel,KQT subfamily,member 4,expressed in sensory outer hair cells
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005249 | voltage-gated potassium channel activity |
-- | -- | | GO:0005251 | delayed rectifier potassium channel activity |
IBA | -- | | GO:0005267 | potassium channel activity |
TAS | 10025409 |
KCNQ4 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for KCNQ4:
2 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Kcnq4):
KCNQ4 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for KCNQ4: Kcnq4tm1Lex Kcnq4tm1.1Tjj
Clone
Products: |  | EMD Millipore Clones for the Expression of KCNQ4 | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNQ4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNQ4 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): KCNQ4 (NM_004700) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNQ4 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KCNQ4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNQ4 |
|
Pathways & Interactions
for KCNQ4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Potassium Channels | | | 2 | Celecoxib Pathway, Pharmacodynamics | | | 3 | Dopamine-DARPP32 Feedback onto cAMP Pathway | | | 4 | Transmission across Chemical Synapses | | | 5 | Development Angiotensin activation of ERK | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNQ4
3 
Reactome Pathways for KCNQ4
1  PharmGKB Pathway for KCNQ4
1 
Kegg Pathway (Kegg details for KCNQ4):
KCNQ4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNQ4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/41 Interacting proteins for KCNQ4 (P566963 ENSP000002629164) via UniProtKB, MINT, STRING, and/or I2D (see all 41)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
KCNQ4 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCNQ4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
KCNQ4 for compounds About GeneDecksing
 Compounds for KCNQ4 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| ML 213 | Kv7.2 and Kv7.4 channel opener | [489402-47-3] |
1 HMDB Compound for KCNQ4 About this table
3 Novoseek chemical compound relationships for KCNQ4 gene About this table
Search CenterWatch for drugs/clinical trials and news about KCNQ4
|
Transcripts
for KCNQ4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KCNQ4 gene (2 alternative transcripts): NM_004700.3 NM_172163.2 Unigene Cluster for KCNQ4: Potassium voltage-gated channel, KQT-like subfamily, member 4 Hs.473058 [show with all ESTs]Unigene Representative Sequence: NM_0047004 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000347132(uc001cgh.2 uc001cgi.2) ENST00000509682 ENST00000443478
ENST00000506017
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNQ4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNQ4 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): KCNQ4 (NM_004700) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNQ4 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KCNQ4 |
Additional cDNA sequence: AF105202.1 AK074957.1 3 DOTS entries: DT.40301648 DT.92046826 DT.99997524 4 AceView cDNA sequences: AF105202 NM_004700 NM_172163 AK074957
GeneLoc Exon Structure
|
Expression
for KCNQ4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KCNQ4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See KCNQ4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNQ4
SOURCE GeneReport for Unigene cluster: Hs.473058
UniProtKB/Swiss-Prot: KCNQ4_HUMAN, P56696Tissue specificity: Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed inheart, brain and skeletal muscle
SABiosciences Custom PCR Arrays for KCNQ4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNQ4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNQ4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNQ4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNQ4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNQ4 |
Orthologs
for KCNQ4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KCNQ4 gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
KCNQ41 |
potassium voltage-gated channel, KQT-like subfamily, more |
78.82(n)
79.56(a) |
|
419643 XM_417791.3 XP_417791.3 |
lizard
(Anolis carolinensis) |
Reptilia |
KCNQ46-- |
-- |
81(a)35(a) |
1 ↔ 1possible ortholog |
GL343308.1(325947-359720) GL343579.1(245406-258714) |
zebrafish
(Danio rerio) |
Actinopterygii |
CABZ01077627.16si:ch73-43d13.16 |
si:ch73-43d13.1 |
68(a)62(a) |
possible ortholog1 ↔ 1 |
Zv9_NA546(9520-23017) 19(43663142-43739582) |
fruit fly
(Drosophila melanogaster) |
Insecta |
KCNQ6 |
KCNQ potassium channel |
26(a) |
1 → many |
2R(6033402-6079899) |
worm
(Caenorhabditis elegans) |
Secernentea |
kqt-13 |
voltage-gated potassium channel |
42(a) |
|
X(6655345-6662969) -- |
ENSEMBL Gene Tree for KCNQ4 (if available)
TreeFam Gene Tree for KCNQ4 (if available) |
Paralogs
for KCNQ4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KCNQ4 gene
- KCNQ32 KCNQ12 KCNQ52 KCNQ22
4 SIMAP similar genes for KCNQ4 using alignment to 2 protein entries: KCNQ4_HUMAN (see all proteins):KCNQ5 KCNQ2 KCNQ3 KCNQ1
KCNQ4 for paralogs About GeneDecksing
|
Genomic Variants
for KCNQ4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KCNQ4 (41249684 - 41306124 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KCNQ4: --
Human Gene Mutation Database (HGMD): KCNQ4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNQ4 |
|
Disorders
/ Diseases
for KCNQ4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KCNQ4 for disorders About GeneDecksing
OMIM gene information: 603537
OMIM disorders: 600101
UniProtKB/Swiss-Prot: KCNQ4_HUMAN, P56696
Defects in KCNQ4 are the cause of deafness autosomal dominant type 2A (DFNA2A) [MIM:600101]. DFNA2A is a formof sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear,the nerve pathways to the brain, or the area of the brain that receives sound information
8  diseases for KCNQ4: About MalaCardshearing loss deafness, autosomal dominant 2a sensorineural hearing loss convulsions
nonsyndromic deafness neuronitis pharyngitis thyroiditis
2 diseases from the University of Copenhagen DISEASES database for KCNQ4:Sensorineural hearing loss Nonsyndromic deafness 2 Novoseek disease relationships for KCNQ4 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hearing loss high-frequency |
87.7 |
2 |
16207888 (2) |
| epilepsy |
22.1 |
1 |
18061539 (1) |
GeneTests: KCNQ4
DFNA 2 Nonsyndromic Hearing Loss
Human Genome Epidemiology (HuGE) Navigator: KCNQ4 (6 documents)
Export disorders for KCNQ4 gene to outside databases
|
Publications
for KCNQ4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KCNQ4 gene, integrated from 9 sources (see all 64):
(articles sorted by number of sources associating them with KCNQ4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. (PubMed id 10025409)1, 2, 3, 9 Kubisch C.... Jentsch T.J. (1999)
- Mutations in the KCNQ4 K+ channel gene, responsible for autosomal dominant hearing loss, cluster in the channel pore region. (PubMed id 10925378)1, 2, 9 Van Hauwe P....Van Camp G. (2000)
- Mutations in the KCNQ4 gene are responsible for autosomal dominant deafness in four DFNA2 families. (PubMed id 10369879)1, 2, 9 Coucke P.J....Van Camp G. (1999)
- Novel mutation in the KCNQ4 gene in a large kindred with dominant progressive hearing loss. (PubMed id 10571947)1, 2, 9 Talebizadeh Z.... Smith S.D. (1999)
- Autosomal dominant progressive sensorineural hearing loss due to a novel mutation in the KCNQ4 gene. (PubMed id 21242547)1, 2 Arnett J....Lesperance M.M. (2011)
- Structural insight into KCNQ (Kv7) channel assembly and channelopathy. (PubMed id 17329207)1, 2 Howard R.J....Minor D.L. (2007)
- International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
- KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology. (PubMed id 11245603)1, 2 Soegaard R....Jensen B.S. (2001)
- Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors. (PubMed id 10713961)1, 2 Selyanko A.A....Brown D.A. (2000)
- Identification of novel mutations in the KCNQ4 gene of patients with nonsyndromic deafness from Taiwan. (PubMed id 17033161)1, 9 Su C.C....Li S.Y. (2007)
|
External Searches for KCNQ4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCNQ4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCNQ4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNQ4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KCNQ4 | Pharmacogenomics, SNPs, Pathways | | Hereditary hearing loss homepage | http://webhost.ua.ac.be/hhh/ | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/KCNQ4 |
|
| | |
About This Section
| Patent Information for KCNQ4 gene:
Search GeneIP for patents involving KCNQ4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCNQ4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for KCNQ4 | | OriGene shRNA RFP for KCNQ4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNQ4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNQ4 | | | OriGene Protein Over-expression Lysate for KCNQ4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KCNQ4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNQ4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNQ4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KCNQ4 | | OriGene Custom Protein Services for KCNQ4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNQ4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNQ4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNQ4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNQ4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNQ4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNQ4 |
| |
 |  |  |  | |
| | | | Tocris compounds for KCNQ4 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | KCNQ4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNQ4 |
|  |  |  |  | | | | ThermoFisher Antibodies for KCNQ4 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KCNQ4 |
| |  | |
|
|
|
