KCNQ3 Gene protein-coding GIFtS : 68 GCID: GC08 M133210
Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member... EBN2 )
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Aliasesfor KCNQ3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 3 1 2 KV7.32 EBN21 2 5 Potassium Channel, Voltage-Gated, Subfamily Q, Member 32 Potassium Channel Subunit Alpha KvLQT32 3 Potassium Voltage-Gated Channel Subfamily KQT Member 32 Voltage-Gated Potassium Channel Subunit Kv7.32 3 KQT-Like 33 BFNC22 5
Export aliases for KCNQ3 gene to outside databases Previous GC identifers: GC08M131852 GC08M133173 GC08M132813 GC08M133097 GC08M128458
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Summariesfor KCNQ3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for KCNQ3 Gene: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in theregulation of neuronal excitability. The M channel is formed by the association of the protein encoded by thisgene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. Mchannel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novelanti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2),also known as epilepsy, benign neonatal type 2 (EBN2). Two variants encoding distinct isoforms have been found.(provided by RefSeq, Mar 2011) GeneCards Summary for KCNQ3 Gene: KCNQ3 (potassium voltage-gated channel, KQT-like subfamily, member 3) is a protein-coding gene. Diseases associated with KCNQ3 include benign neonatal epilepsy 2 myokymia with neonatal epilepsy related super-pathways are Potassium Channels and Axon guidance . GO annotations related to this gene include delayed rectifier potassium channel activity and potassium channel activity . An important paralog of this gene is KCNQ1 . UniProtKB/Swiss-Prot: KCNQ3_HUMAN, O43525 Function : Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form apotassium channel with essentially identical properties to the channel underlying the native M-current, a slowlyactivating and deactivating potassium conductance which plays a critical role in determining the subthresholdelectrical excitability of neurons as well as the responsiveness to synaptic inputs summary
for KCNQ3 Gene: Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises theCa2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunitscontain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formedwithin subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3. Gene Wiki entry for KCNQ3 (KvLQT3) Gene
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Genomic Viewsfor KCNQ3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000008.10 NT_008046.16 NC_018919.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KCNQ3 gene promoter:HFH-3 Pax-5 Egr-1 Lmo2 MIF-1 Cdc5 C/EBPalpha Egr-4 STAT3 Other transcription factors Search SABiosciences Chromatin IP Primers for KCNQ3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 8q24 Ensembl cytogenetic band: 8q24.22 HGNC cytogenetic band: 8q24 KCNQ3 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08M133210: view genomic region
(about GC identifiers )
Start: 133,133,105 bp from pter End:
133,493,200 bp from pter
Size: 360,096 bases Orientation:
minus strand
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Proteinsfor KCNQ3 gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: KCNQ3_HUMAN, O43525 See
protein sequence )Recommended Name: Size : 872 amino acids; 96742 DaSubunit : Heteromultimer with KCNQ2 or KCNQ5. May associate with KCNE2Subcellular location : Membrane; Multi-pass membrane proteinMiscellaneous : Mutagenesis experiments were carried out in Xenopus oocytes by coexpression of either KCNQ3(mut)and KCNQ2 at the ratio of 1:1, or of KCNQ3(mut), KCNQ3(wt) and KCNQ2 at the ratio of 1:1:2, to mimic thesituation in a heterozygous patient with BFNC2 disease
Secondary accessions : B4DJY4 E7EQ89Alternative splicing : 2 isoforms : O43525-1 O43525-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KCNQ3: NX_O43525 Explore proteomics data for KCNQ3 at MOPED Post-translational modifications:
View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_O43525 KCNQ3 Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins (2 alternative transcripts): NP_001191753.1 NP_004510.1 ENSEMBL proteins: ENSP00000373648 ENSP00000429799 ENSP00000428790 Reactome Protein details: O43525 Human Recombinant Protein Products for KCNQ3: Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing KCNQ3 Antibody Products: Assay Products for KCNQ3:
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Protein
Domains /for KCNQ3 gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section HGNC Gene Families: KCN: Potassium channels Kv: Voltage-gated ion channels / Potassium channels IUPHAR Guide to PHARMACOLOGY protein family classification: Kv 7.3 Voltage-gated potassium channels 5/6 InterPro protein domains (see all 6 ):
Graphical View of Domain Structure for InterPro Entry O43525 ProtoNet protein and cluster: O43525
2 Blocks protein domains : IPB003948 IPB013821 UniProtKB/Swiss-Prot: KCNQ3_HUMAN, O43525 Domain : The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged aminoacids at every third position (By similarity) Similarity : Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamilyAbout GeneDecksing
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Functionfor KCNQ3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
genOway ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
Vector BioLabs ,
and Sirion Biotech ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: KCNQ3_HUMAN, O43525 Function : Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form apotassium channel with essentially identical properties to the channel underlying the native M-current, a slowlyactivating and deactivating potassium conductance which plays a critical role in determining the subthresholdelectrical excitability of neurons as well as the responsiveness to synaptic inputs
Genatlas biochemistry entry for KCNQ3 potassium voltage-gated channel,KQT subfamily,member 3,coassembling with KCNQ2 to contribute M-channel,localizedin central nervous system (hyppocampus,neocortex and cerebellar cortex) Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for KCNQ3 :6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kcnq3) :About GeneDecksing Animal Models: Cell Line GenScript Custom overexpressing Cell Line Services for KCNQ3 Search LifeMap BioReagents cell lines for KCNQ3 In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNQ3
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Pathways & Interactionsfor KCNQ3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for KCNQ3 About (see all 8 ) See pathways by source SuperPath Contained pathways About 1 Potassium Channels 2 Axon guidance 3 Transmission across Chemical Synapses 4 Circadian entrainment 5 Synaptic transmission: ion currents
Pathways by source See SuperPaths Show all pathways 2 1 5/7 (see all 7 )1 KCNQ3 1 (Kegg details for KCNQ3) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNQ3 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/57 Interacting proteins for KCNQ3 (O43525 3 ENSP00000373648 4 via UniProtKB, MINT, STRING , and/or I2D (see all 57 )About this table Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing
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Drugs & Compoundsfor KCNQ3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Compounds for KCNQ3 available from Tocris Bioscience About this table Compound Action
CAS
# ICA 110381 KV7.2/7.3 activator; displays anticonvulsant properties [325457-99-6] XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4] JNJ 303 Potent and selective IKs blocker [878489-28-2] E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0] ShK-Dap22 Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro [220384-25-8]
1 HMDB Compound for KCNQ3 About this table 3 DrugBank Compounds for KCNQ3 About this table 4 IUPHAR Ligands for KCNQ3 (Kv 7.3) About this table 4 Novoseek inferred chemical compound relationships for KCNQ3 gene About this table KCNQ3
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Transcriptsfor KCNQ3 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Sirion Biotech ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for KCNQ3 gene (2 alternative transcripts): NM_001204824.1 NM_004519.3 Unigene Cluster for KCNQ3:
Potassium voltage-gated channel, KQT-like subfamily, member 3 Hs.374023 [show with all ESTs ] Unigene Representative Sequence: NM_004519 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000388996 (uc003yti.3 uc003ytj.3 uc010mdt.3 ) ENST00000521134 ENST00000519445 ENST00000519589 Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: AF033347.1 AK094705.1 AK095711.1 AK296293.1 BC128576.1 BX538233.1 BX538295.1
8 DOTS entries : DT.97770198 DT.211817
DT.120630292 DT.121472710 DT.207846 DT.95232233 DT.120630310 DT.121472728 24/74 AceView cDNA sequences (see all 74 ):
AF033347 NM_004519 BX102087 AK095711 Z39292 AL707265 AK094705 BX441434 BF478234 BX506936 Z43216 AL707492 AL707270 BF000056 AL701655 AI355924 BX538295 AI124734 BE894188 BX538233 BX409804 AI278419 BX409805 CK005312 GeneLoc Exon Structure
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Expression for KCNQ3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section KCNQ3 expression in normal human tissues
(normalized intensities) KCNQ3 embryonic expression: see See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: AATCCATTATAbout this image
KCNQ3 expression in embryonic tissues and stem cells About this table LifeMap ,
the Embryonic Development and Stem Cells Database 5/4 selected tissues (see all 4 ) fully expand See KCNQ3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KCNQ3 SOURCE GeneReport for Unigene cluster: Hs.374023 UniProtKB/Swiss-Prot: KCNQ3_HUMAN, O43525 Tissue specificity : Predominantly expressed in brainSABiosciences Expression via Pathway-Focused PCR Array including KCNQ3 : Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNQ3
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Orthologsfor KCNQ3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for KCNQ3 gene from 6/13 species (see all 13 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Kcnq31 5
potassium voltage-gated channel, subfamily Q, member more 1, 5
90.47(n) 1 95.75(a) 1
15 (29.16 cM) 5 110862 1 NM_152923.2 1 NP_690887.2 1 65995171 5
chicken Aves KCNQ31
potassium voltage-gated channel, KQT-like subfamily, more
79.31(n) 87.48(a)
420325 XM_003640867.1 XP_003640915.1
lizard Reptilia KCNQ36
potassium voltage-gated channel, KQT-like subfamil... 78(a)
1 ↔ 1
4(319630-489150)
zebrafish Actinopterygii kcnq31
potassium voltage-gated channel, KQT-like subfamily, more
68.23(n) 72.42(a)
799747 XM_003197933.1 XP_003197981.1
fruit fly Insecta KCNQ6
KCNQ potassium channel
26(a)
1 → many
2R(6033402-6079899)
worm Secernentea kqt-13
voltage-gated potassium channel
38(a)
X(6655345-6662969) --
ENSEMBL Gene Tree for KCNQ3 (if available)TreeFam Gene Tree for KCNQ3 (if available)
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Paralogsfor KCNQ3 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for KCNQ3 gene KCNQ1 2 KCNQ2 2 KCNQ5 2 KCNQ4 2 5 SIMAP similar genes for KCNQ3 using alignment to 3 protein entries: KCNQ3_HUMAN (see all proteins ):KCNQ4 KCNQ5 KCNQ2 KCNQ1 KCNN4 About GeneDecksing
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Genomic Variantsfor KCNQ3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 8 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for KCNQ3 (133133105 - 133383105 bp, first 250kb of KCNQ3)
Structural Variations Database of Genomic Variants (DGV) 10/12 variations for KCNQ3 (see all 12 ): About this table Human Gene Mutation Database (HGMD) : KCNQ3 SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing KCNQ3
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Disorders
/ Diseasesfor KCNQ3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Novoseek , Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section OMIM gene information: 602232 OMIM disorders : 121201 UniProtKB/Swiss-Prot: KCNQ3_HUMAN, O43525 Seizures, benign familial neonatal 2 (BFNS2) [MIM:121201]: A disorder characterized by clusters ofseizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age andshow normal psychomotor development. The disorder is distinguished from benign familial infantile seizures by anearlier age at onset. Note=The disease is caused by mutations affecting the gene represented in this entry 13 : About MalaCards benign neonatal epilepsy 2 myokymia with neonatal epilepsy convulsions benign familial neonatal dominant form benign neonatal seizures myokymia episodic ataxia epilepsy syndrome juvenile myoclonic epilepsy long qt syndrome idiopathic generalized epilepsy migraine ataxia neuronitis 4 diseases from the University of Copenhagen DISEASES database for KCNQ3 :Brain disease Long QT syndrome Episodic ataxia Speech disorder About GeneDecksing 7 Novoseek inferred disease relationships for KCNQ3 gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
familial benign neonatal convulsions
98.6
20
10852552 (2), 9827540 (1), 10446744 (1), 11579434 (1) (see
all 18 )
neonatal convulsions benign
90.1
2
10884071 (1), 18625963 (1)
epilepsy, idiopathic generalized
84.1
4
10996506 (1), 19464834 (1), 9677360 (1), 10941184 (1)
epilepsy frontal lobe
78.3
3
11579434 (1), 11888238 (1), 15264690 (1)
epilepsy
74.2
15
19464834 (2), 18625963 (2), 9827540 (1), 10996506 (1) (see
all 11 )
epilepsy generalized
72.9
1
11784811 (1)
seizures febrile
72.4
1
19853223 (1)
Genetic Association Database (GAD): KCNQ3 Human Genome Epidemiology (HuGE) Navigator: KCNQ3 (8 documents) Export disorders for KCNQ3 gene to outside databases
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Publicationsfor KCNQ3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for KCNQ3 gene, integrated from 9 sources (see all 108 ):(articles sorted by number of sources associating them with KCNQ3) Utopia : connect your pdf to the dynamic
Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine. (PubMed id 10908292) 1 , 2 , 7(2000) Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels. (PubMed id 10953053) 1 , 2 , 7(2000) A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. (PubMed id 9425900) 1 , 2 , 3(1998) Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy. (PubMed id 9677360) 1 , 2 , 9(1998) Surface expression and single channel properties of KCNQ2/KCNQ3, M- type K+ channels involved in epilepsy. (PubMed id 10788442) 1 , 2 , 9(2000) A novel mutation of KCNQ3 (c.925T-->C) in a Japanese family with benign familial neonatal convulsions. (PubMed id 10852552) 1 , 2 , 9(2000) KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum. (PubMed id 14534157) 1 , 2 , 9(2003) Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current. (PubMed id 10684873) 1 , 2 , 9(2000) Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy. (PubMed id 9872318) 1 , 2 , 9(1998) A high-density association screen of 155 ion transport genes for involvement with common migraine. (PubMed id 18676988) 1 , 4, 9(2008)
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External Searches for KCNQ3 gene
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Genome Databases showing KCNQ3 gene
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Entrez Gene ,
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Specialized Databases showing KCNQ3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for KCNQ3 gene: KCNQ3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor KCNQ3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Sirion Biotech , Cell lines from GenScript , and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory ,
genOway )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNQ3 QIAGEN SeqTarget long-range PCR primers for resequencing KCNQ3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Tocris compounds for KCNQ3
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNQ3
ThermoFisher Antibody for KCNQ3
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KCNQ3
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