Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KCNQ2 Gene

protein-coding   GIFtS: 68
GCID: GC20M062038

Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member...


(Previous symbols: EBN, EBN1)
  See KCNQ2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 21 2     BFNC2
EBN11 2 5     ENB12
EBN1 2     HNSPC2
Neuroblastoma-Specific Potassium Channel Subunit Alpha KvLQT22 3     KCNA112
Voltage-Gated Potassium Channel Subunit Kv7.22 3     KV7.22
KQT-Like 22 3     KVEBN12
BFNS12 5     Neuroblastoma-Specific Potassium Channel Protein2
EIEE72 5     Potassium Voltage-Gated Channel Subfamily KQT Member 22

External Ids:    HGNC: 62961   Entrez Gene: 37852   Ensembl: ENSG000000750437   OMIM: 6022355   UniProtKB: O435263   

Export aliases for KCNQ2 gene to outside databases

Previous GC identifers: GC20M061909 GC20M062710 GC20M062757 GC20M062756 GC20M061502 GC20M058763


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for KCNQ2 Gene:
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the
regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this
gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are
inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug.
Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy,
benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNQ2 Gene:
KCNQ2 (potassium voltage-gated channel, KQT-like subfamily, member 2) is a protein-coding gene. Diseases associated with KCNQ2 include epileptic encephalopathy, early infantile, 7, and myokymia. GO annotations related to this gene include voltage-gated potassium channel activity and potassium channel activity. An important paralog of this gene is KCNQ1.

UniProtKB/Swiss-Prot: KCNQ2_HUMAN, O43526
Function: Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium
channel with essentially identical properties to the channel underlying the native M-current, a slowly activating
and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical
excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by
linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly
suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic
receptors

summary for KCNQ2 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNQ2 (KvLQT2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  NT_187625.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNQ2 gene promoter:
         NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNQ2 promoter sequence
   Search Chromatin IP Primers for KCNQ2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNQ2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.3   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

KCNQ2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNQ2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M062038:  view genomic region     (about GC identifiers)

Start:
62,037,542 bp from pter      End:
62,103,993 bp from pter
Size:
66,452 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KCNQ2_HUMAN, O43526 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily KQT member 2  
Size: 872 amino acids; 95848 Da
Subunit: Heteromultimer with KCNQ3. May associate with KCNE2
Miscellaneous: Inclusion of isoform 6 in heteromultimers results in attenuation of potassium current. Prominent
expression of isoform 6 in the developing brain may alter firing repertoires of immature neurons excitability to
provide cues for proliferation rather than differentiation
Miscellaneous: Mutagenesis experiments were carried out in Xenopus oocytes by coexpression of either KCNQ2(mut)
and KCNQ3 at the ratio of 1:1, or of KCNQ2(mut), KCNQ2(wt) and KCNQ3 at the ratio of 1:1:2, to mimic the
situation in a heterozygous patient with BFNC1 disease
Secondary accessions: O43796 O75580 O95845 Q4VXP4 Q4VXR6 Q5VYT8 Q96J59 Q99454
Alternative splicing: 6 isoforms:  O43526-1   O43526-2   O43526-3   O43526-4   O43526-5   O43526-6   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for KCNQ2: NX_O43526

Explore proteomics data for KCNQ2 at MOPED

Post-translational modifications: 

  • In Xenopus oocytes KCNQ2/KCNQ3 heteromeric current can be increased by intracellular cyclic AMP, an effect that
    depends on phosphorylation of Ser-52 in the N-terminus region1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KCNQ2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_004509.2  NP_742104.1  NP_742105.1  NP_742106.1  NP_742107.1  

    ENSEMBL proteins: 
     ENSP00000349789   ENSP00000352035   ENSP00000353668   ENSP00000359244   ENSP00000339611  
     ENSP00000345523   ENSP00000346601   ENSP00000352718  
    Reactome Protein details: O43526

    KCNQ2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KCNQ2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KCNQ2
    GenScript Custom Purified and Recombinant Proteins Services for KCNQ2
    Novus Biologicals KCNQ2 Protein
    Novus Biologicals KCNQ2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KCNQ2

     
    Search eBioscience for Proteins for KCNQ2 

     
    antibodies-online proteins for KCNQ2 (2 products) 

     
    antibodies-online peptides for KCNQ2

    KCNQ2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNQ2
    Browse R&D Systems for Antibodies
    OriGene Antibodies for KCNQ2
    OriGene Custom Antibody Services for KCNQ2
    Novus Biologicals KCNQ2 Antibodies
    Abcam antibodies for KCNQ2 (Q5VYU0, O43526)
    Cloud-Clone Corp. Antibodies for KCNQ2
    ThermoFisher Antibody for KCNQ2
    antibodies-online antibodies for KCNQ2 (67 products) 

    KCNQ2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KCNQ2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KCNQ2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KCNQ2
    Cloud-Clone Corp. CLIAs for KCNQ2
    Search eBioscience for ELISAs for KCNQ2 
    antibodies-online kits for KCNQ2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    KCN: Potassium channels
    Kv: Voltage-gated ion channels / Potassium channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kv7.2
    Voltage-gated potassium channels

    Selected InterPro protein domains (see all 7):
     IPR003947 K_chnl_volt-dep_KCNQ2
     IPR020969 Ankyrin-G_BS
     IPR005821 Ion_trans_dom
     IPR003937 K_chnl_volt-dep_KCNQ
     IPR028325 VG_K_chnl

    Graphical View of Domain Structure for InterPro Entry O43526

    ProtoNet protein and cluster: O43526

    2 Blocks protein domains:
    IPB003947 KCNQ2 voltage-gated potassium channel signature
    IPB013821 KCNQ voltage-gated potassium channel


    UniProtKB/Swiss-Prot: KCNQ2_HUMAN, O43526
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position (By similarity)
    Similarity: Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.2/KCNQ2 sub-subfamily


    Find genes that share domains with KCNQ2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNQ2_HUMAN, O43526
    Function: Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium
    channel with essentially identical properties to the channel underlying the native M-current, a slowly activating
    and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical
    excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by
    linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly
    suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic
    receptors

         Genatlas biochemistry entry for KCNQ2:
    potassium voltage-gated channel gene,KQT subfamily,widely expressed,coassembling with KCNQ3 to contribute
    M-channel,with four alternatively spliced isoforms,localized in central nervous system (hyppocampus,neocortex and
    cerebellar cortex)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005249voltage-gated potassium channel activity TAS9677360
    GO:0005251delayed rectifier potassium channel activity IBA--
    GO:0005267potassium channel activity TAS9430594
    GO:0030506ankyrin binding IPI16525039
         
    Find genes that share ontologies with KCNQ2           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Kcnq2):
     behavior/neurological  growth/size/body  mortality/aging  nervous system  reproductive system 
     respiratory system 

    Find genes that share phenotypes with KCNQ2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kcnq2tm1Hsa for KCNQ2

       genOway: Develop your customized and physiologically relevant rodent model for KCNQ2

    miRNA
    Products:
        
    miRTarBase miRNAs that target KCNQ2:
    hsa-mir-375 (MIRT020071), hsa-mir-148b-3p (MIRT019416), hsa-mir-26b-5p (MIRT030213)

    Block miRNA regulation of human, mouse, rat KCNQ2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate KCNQ2
    SwitchGear 3'UTR luciferase reporter plasmidKCNQ2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KCNQ2
    Predesigned siRNA for gene silencing in human, mouse, rat KCNQ2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KCNQ2

    Clone
    Products:
         
    OriGene clones in human, mouse for KCNQ2 (see all 37)
    OriGene ORF clones in mouse, rat for KCNQ2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): KCNQ2 (NM_172107)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNQ2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNQ2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KCNQ2
    Browse ESI BIO Cell Lines and PureStem Progenitors for KCNQ2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNQ2

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11417) for KCNQ2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KCNQ2_HUMAN, O43526: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    nucleus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IEA--
    GO:0016020membrane ----
    GO:0033268node of Ranvier ISS16525039
    GO:0043194axon initial segment ISS16525039

    Find genes that share ontologies with KCNQ2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for KCNQ2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters outward current0.41
    Voltage gated Potassium channels0.43
    2L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    3Transmission across Chemical Synapses
    Neuronal System0.68
    4Circadian entrainment
    Cholinergic synapse0.37
    5Synaptic transmission ion currents
    Synaptic transmission ion currents


    Find genes that share SuperPaths with KCNQ2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KCNQ2
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    2 Reactome Pathways for KCNQ2
        Interaction between L1 and Ankyrins
    Voltage gated Potassium channels

    1 PharmGKB Pathway for KCNQ2
        Celecoxib Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for KCNQ2):
        Cholinergic synapse

        Pathway & Disease-focused RT2 Profiler PCR Array including KCNQ2: 
              Neuronal Ion Channels in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KCNQ2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KCNQ2 (O435262, 3 ENSP000003520354) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARIH2O953762, 3MINT-63297 I2D: score=4 
    CALM1P621583, ENSP000003494674I2D: score=5 STRING: ENSP00000349467
    CALM2P621583, ENSP000002722984I2D: score=5 STRING: ENSP00000272298
    CALM3P621583, ENSP000002912954I2D: score=5 STRING: ENSP00000291295
    KCNQ3O435253, ENSP000003736484I2D: score=2 STRING: ENSP00000373648
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006813potassium ion transport TAS9677360
    GO:0007268synaptic transmission TAS--
    GO:0007399nervous system development TAS9425895
    GO:0007411axon guidance TAS--

    Find genes that share ontologies with KCNQ2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNQ2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    1 HMDB Compound for KCNQ2    About this table
    CompoundSynonyms CAS #PubMed Ids
    PotassiumK+ (see all 16)7440-09-7--

    4 DrugBank Compounds for KCNQ2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ezogabine D-23129 (see all 5)150812-12-7target--15662042 17456683 17184917 10908292 10953053
    DiclofenacDiclofenac Acid (see all 4)15307-86-5targetother15598972 18206251
    AmitriptylineAmitriprolidine (see all 5)50-48-6targetinhibitor17456683
    Meclofenamic acidAcide meclofenamique [INN-French] (see all 6)644-62-2targetother15598972

    10 IUPHAR Ligands for KCNQ2 (Kv7.2)    About this table
    LigandTypeActionAffinityPubmed IDs
    XE991
    Pore BlockerNone6.159836639
    zinc pyrithione
    ActivatorNone5.817435769
    L735821
    Pore BlockerNone5.89827540
    retigabine
    ActivatorNone5.611466425
    N-(S)-MPEPAamide
    ActivatorNone5.512852750 16904708
    linopirdine
    Pore BlockerNone5.329836639
    BMS204352
    ActivatorNone511378159
    flupirtine
    ActivatorNone514736843
    tetraethylammonium
    Pore BlockerNone3.810953053 9836639 10711337
    PIP2
    ActivatorNone3.716251430

    7 Novoseek inferred chemical compound relationships for KCNQ2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retigabine 89.8 7 10908292 (2), 15901787 (2)
    potassium 77.7 36 12871719 (2), 9425895 (2), 9430594 (2), 15249611 (2) (see all 29)
    linopirdine 76.3 1 19298256 (1)
    valine 15.6 2 17044971 (1), 17475800 (1)
    acetylcholine 4.03 2 15068253 (1), 17008177 (1)
    sodium 0 2 15068253 (1), 19464834 (1)
    histamine 0 1 12147327 (1)



    Find genes that share compounds with KCNQ2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KCNQ2 gene (5 alternative transcripts): 
    NM_004518.4  NM_172106.1  NM_172107.2  NM_172108.3  NM_172109.1  

    Unigene Clusters for KCNQ2:

    Potassium voltage-gated channel, KQT-like subfamily, member 2
    Hs.161851  [show with all ESTs], Hs.652468  [show with all ESTs]
    Unigene Representative Sequences: NM_172107, BC020384
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357249(uc002yfa.1 uc002yfb.1) ENST00000359125(uc002yey.1)
    ENST00000360480 ENST00000370224 ENST00000344462 ENST00000370221(uc011aax.1)
    ENST00000482957 ENST00000344425(uc002yfc.1) ENST00000354587 ENST00000359689

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KCNQ2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate KCNQ2
    SwitchGear 3'UTR luciferase reporter plasmidKCNQ2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KCNQ2
    Predesigned siRNA for gene silencing in human, mouse, rat KCNQ2
    Clone
    Products:
         
    OriGene clones in human, mouse for KCNQ2 (see all 37)
    OriGene ORF clones in mouse, rat for KCNQ2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): KCNQ2 (NM_172107)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNQ2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNQ2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KCNQ2
    OriGene qSTAR qPCR primer pairs in human, mouse for KCNQ2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNQ2
      QuantiTect SYBR Green Assays in human, mouse, rat KCNQ2
      QuantiFast Probe-based Assays in human, mouse, rat KCNQ2
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11417) for KCNQ2 

    Additional mRNA sequence: 

    BC020384.1 BC127262.1 

    16 DOTS entries:

    DT.440674  DT.75191622  DT.95371610  DT.95371605  DT.100744137  DT.100017848  DT.421991  DT.40283987 
    DT.95074472  DT.91644063  DT.100669553  DT.120801397  DT.91868009  DT.95193752  DT.91800171  DT.95335833 

    Selected AceView cDNA sequences (see all 87):

    BX098600 AF074247 BQ787998 CR621726 BT007043 NM_172106 AI571287 BF981606 
    D82346 BE257127 BU785103 AI638340 AI672562 NM_004518 NM_172109 BC000699 
    BC020384 AW292874 AI871417 AA812513 BF530321 BM547930 Y15065 BI554225 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KCNQ2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19
    SP1:        -           -                                         -     -     -           -     -                                         -               
    SP2:        -           -                                         -     -     -                                                                           
    SP3:                    -                                                                                                                                 
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for KCNQ2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KCNQ2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGTGGCGT
    KCNQ2 Expression
    About this image


    KCNQ2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 22 entries
             Thalamus
             Ventral/hypothalamic-like neurons
             Fetal Neuronal Stem Cells (NSC)   
             Septum   
     
     Neurons
             Ventral/hypothalamic-like neurons
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Testis (Reproductive System)
    KCNQ2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNQ2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.161851 Hs.652468

    UniProtKB/Swiss-Prot: KCNQ2_HUMAN, O43526
    Tissue specificity: In adult and fetal brain. Highly expressed in areas containing neuronal cell bodies, low in
    spinal chord and corpus callosum. Isoform 2 is preferentially expressed in differentiated neurons. Isoform 6 is
    prominent in fetal brain, undifferentiated neuroblastoma cells and brain tumors

        Pathway & Disease-focused RT2 Profiler PCR Array including KCNQ2: 
              Neuronal Ion Channels in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KCNQ2
    OriGene qSTAR qPCR primer pairs in human, mouse for KCNQ2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNQ2
    QuantiTect SYBR Green Assays in human, mouse, rat KCNQ2
    QuantiFast Probe-based Assays in human, mouse, rat KCNQ2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNQ2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for KCNQ2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnq21 , 5 potassium voltage-gated channel, subfamily Q, member more1, 5 87.15(n)1
    95.77(a)1
      2 (103.57 cM)5
    165361  NM_010611.21  NP_034741.21 
     1810755795 
    chicken
    (Gallus gallus)
    Aves KCNQ21 potassium voltage-gated channel, KQT-like subfamily, more 83.2(n)
    90.69(a)
      428151  XM_001233449.2  XP_001233450.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNQ26
    potassium voltage-gated channel, KQT-like subfamil...
    85(a)
    1 ↔ 1
    4(154033759-154113799)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.186262 Transcribed sequence with moderate similarity to protein more 73.53(n)    AL783084.2 
    zebrafish
    (Danio rerio)
    Actinopterygii kcnq21 potassium voltage-gated channel, KQT-like subfamily, more 73.88(n)
    78.89(a)
      100537363  XM_003198845.2  XP_003198893.1 
    worm
    (Caenorhabditis elegans)
    Secernentea kqt-13 voltage-gated potassium channel 39(a)   X(6655345-6662969)   --


    ENSEMBL Gene Tree for KCNQ2 (if available)
    TreeFam Gene Tree for KCNQ2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KCNQ2 gene
    KCNQ12  KCNQ32  KCNQ52  KCNQ42  
    4 SIMAP similar genes for KCNQ2 using alignment to 6 protein entries:     KCNQ2_HUMAN (see all proteins):
    KCNQ5    KCNQ4    KCNQ3    KCNQ1

    Find genes that share paralogs with KCNQ2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KCNQ2 (see all 1915)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289396831,2,,4
    CSeizures, benign familial neonatal 1 (BFNS1)4 pathogenic162071027(-) CAAGTA/GCCCCC 10 Y C mis1 ese30--------
    rs289396841,2,,4
    CSeizures, benign familial neonatal 1 (BFNS1)4 pathogenic162076062(-) ACCGGC/TGGGGA 10 R W mis1 ese30--------
    VAR_0269914
    Epileptic encephalopathy, early infantile, 7 (EIEE7)4--see VAR_0269912 S W mis40--------
    VAR_0269874
    Seizures, benign familial neonatal 1 (BFNS1)4--see VAR_0269872 R W mis40--------
    VAR_0269904
    Seizures, benign familial neonatal 1 (BFNS1)4--see VAR_0269902 L F mis40--------
    VAR_0269924
    Seizures, benign familial neonatal 1 (BFNS1)4--see VAR_0269922 R Q mis40--------
    VAR_0109314
    Seizures, benign familial neonatal 1 (BFNS1)4--see VAR_0109312 A T mis40--------
    VAR_0269884
    Seizures, benign familial neonatal 1 (BFNS1)4--see VAR_0269882 M V mis40--------
    VAR_0269934
    Seizures, benign familial neonatal 1 (BFNS1)4--see VAR_0269932 K N mis40--------
    VAR_0269894
    Seizures, benign familial neonatal 1 (BFNS1)4--see VAR_0269892 H Q mis40--------

    HapMap Linkage Disequilibrium report for KCNQ2 (62037542 - 62103993 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KCNQ2 (see all 35):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722926CNV Deletion23290073
    esv2722922CNV Deletion23290073
    esv2722924CNV Deletion23290073
    esv2722925CNV Deletion23290073
    esv2722927CNV Deletion23290073
    esv2722923CNV Deletion23290073
    esv1486514CNV Insertion17803354
    esv1183382CNV Insertion17803354
    esv1065575CNV Insertion17803354
    esv996888CNV Insertion20482838

    Human Gene Mutation Database (HGMD): KCNQ2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNQ2
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNQ2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602235   
    OMIM disorders: 121200  613720  
    UniProtKB/Swiss-Prot: KCNQ2_HUMAN, O43526
  • Seizures, benign familial neonatal 1 (BFNS1) [MIM:121200]: A disorder characterized by clusters of
    seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and
    show normal psychomotor development. Some rare cases manifest an atypical severe phenotype associated with
    epileptic encephalopathy and psychomotor retardation. The disorder is distinguished from benign familial
    infantile seizures by an earlier age at onset. In some patients, neonatal convulsions are followed later in life
    by myokymia, a benign condition characterized by spontaneous involuntary contractions of skeletal muscles fiber
    groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows
    continuous motor unit activity with spontaneous oligo- and multiplet-discharges of high intraburst frequency
    (myokymic discharges). Some patients may have isolated myokymia. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Epileptic encephalopathy, early infantile, 7 (EIEE7) [MIM:613720]: An autosomal dominant seizure disorder
    characterized by infantile onset of refractory seizures with resultant delayed neurologic development and
    persistent neurologic abnormalities. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 13 diseases for KCNQ2:    
    About MalaCards
    epileptic encephalopathy, early infantile, 7    myokymia    benign familial neonatal epilepsy    seizures, benign neonatal, 1
    kcnq2-related disorders    kanzaki disease    seizures, benign familial infantile, 3    benign neonatal seizures
    spermatogenic failure 12    benign familial infantile seizures 2    epileptic encephalopathy, early infantile, 17    generalized epilepsy with febrile seizures plus
    neuroblastoma

    2 diseases from the University of Copenhagen DISEASES database for KCNQ2:
    Brain disease     Long QT syndrome

    Find genes that share disorders with KCNQ2           About GenesLikeMe

    10 Novoseek inferred disease relationships for KCNQ2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    familial benign neonatal convulsions 98.6 32 15178210 (3), 18166285 (2), 18483067 (2), 17475800 (2) (see all 24)
    neonatal convulsions benign 95.1 3 10884071 (1), 10774989 (1), 18625963 (1)
    seizures, benign neonatal 93.5 3 17140792 (1), 18249525 (1), 15596769 (1)
    epilepsy, idiopathic generalized 81.4 4 10363917 (2), 19464834 (1), 9677360 (1)
    convulsions neonatal 77.8 1 10482260 (1)
    epilepsy 75 28 18625963 (3), 9827540 (1), 10996506 (1), 9872318 (1) (see all 25)
    epilepsy frontal lobe 67.3 3 15264690 (1), 17008177 (1), 19822871 (1)
    seizures febrile 62.5 4 12395102 (2), 19853223 (1), 17008177 (1)
    epilepsy generalized 60.5 2 17008177 (1), 11784811 (1)
    mental retardation 4.66 1 15249611 (1)

    Genetic Association Database (GAD): KCNQ2
    Human Genome Epidemiology (HuGE) Navigator: KCNQ2 (3 documents)

    Export disorders for KCNQ2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KCNQ2 gene, integrated from 10 sources (see all 152):
    (articles sorted by number of sources associating them with KCNQ2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. (PubMed id 9425895)1, 2, 3, 9 Singh N.A....Leppert M. (Nat. Genet. 1998)
    2. Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine. (PubMed id 10908292)1, 2, 7, 9 Main M.J.... Burbidge S.A. (Mol. Pharmacol. 2000)
    3. Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels. (PubMed id 10953053)1, 2, 7 Wickenden A.D.... Wagoner P.K. (Mol. Pharmacol. 2000)
    4. KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum. (PubMed id 14534157)1, 2, 9 Singh N.A.... Leppert M.F. (Brain 2003)
    5. Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy. (PubMed id 9677360)1, 2, 9 Yang W.-P.... Blanar M.A. (J. Biol. Chem. 1998)
    6. KCNQ2 and KCNQ3 mutations contribute to different idiopathic epilepsy syndromes. (PubMed id 18625963)1, 4, 9 Neubauer B.A....Sander T. (Neurology 2008)
    7. Surface expression and single channel properties of KCNQ2/KCNQ3, M- type K+ channels involved in epilepsy. (PubMed id 10788442)1, 2, 9 Schwake M.... Jentsch T.J. (J. Biol. Chem. 2000)
    8. Peripheral nerve hyperexcitability due to dominant-negative KCNQ2 mutations. (PubMed id 17872363)1, 2, 9 Wuttke T.V....Lerche H. (Neurology 2007)
    9. A novel mutation in KCNQ2 associated with BFNC, drug resistant epilepsy, and mental retardation. (PubMed id 15249611)1, 2, 9 Borgatti R.... Bassi M.T. (Neurology 2004)
    10. Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel. (PubMed id 11572947)1, 2, 9 Dedek K....Steinlein O.K. (Proc. Natl. Acad. Sci. U.S.A. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3785 HGNC: 6296 AceView: KCNQ2 Ensembl:ENSG00000075043 euGenes: HUgn3785
    ECgene: KCNQ2 Kegg: 3785 H-InvDB: KCNQ2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KCNQ2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=KCNQ2[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KCNQ2 gene:
    Search GeneIP for patents involving KCNQ2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNQ2
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for KCNQ2   OriGene RNAi products in human, mouse, rat for KCNQ2  
     OriGene qPCR primer pairs and template standards for KCNQ2   OriGene Protein Over-expression Lysate for KCNQ2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KCNQ2  
     OriGene qSTAR qPCR primer pairs in human, mouse for KCNQ2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KCNQ2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KCNQ2   OriGene Custom Protein Services for KCNQ2  

     
     
     Block miRNA regulation of human, mouse, rat KCNQ2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KCNQ2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNQ2 Predesigned siRNA for gene silencing in human, mouse, rat KCNQ2
     QuantiFast Probe-based Assays in human, mouse, rat KCNQ2 QuantiTect SYBR Green Assays in human, mouse, rat KCNQ2
     PCR Arrays including human, mouse, rat KCNQ2 Search Chromatin IP Primers for KCNQ2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNQ2  GeneGlobe Interaction Network for KCNQ2
     Regulatory tfbs in KCNQ2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for KCNQ2 GenScript cDNA clones with any tag delivered in your preferred vector for KCNQ2
     GenScript Custom Assay Services for KCNQ2 GenScript Custom overexpressing Cell Line Services for KCNQ2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for KCNQ2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KCNQ2 antibodies
     KCNQ2 proteins
     KCNQ2 lysates
     Antibodies for KCNQ2
     See all of Abcam's Antibodies, Kits and Proteins for KCNQ2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for KCNQ2
     Antibodies for KCNQ2
     ELISAs for KCNQ2
     CLIAs for KCNQ2



     Browse ESI BIO Cell Lines and PureStem Progenitors for KCNQ2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNQ2
     SwitchGear 3'UTR luciferase reporter plasmids for KCNQ2
     SwitchGear Promoter luciferase reporter plasmids for KCNQ2
     ThermoFisher Antibody for KCNQ2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNQ2
     Browse compounds at ApexBio
     Search Addgene for plasmids for KCNQ2
      Search eBioscience for proteins for KCNQ2
      Search eBioscience for elisas for KCNQ2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for KCNQ2
     antibodies-online antibodies for KCNQ2 (67 products)
     antibodies-online kits for KCNQ2 (6 products)
     antibodies-online peptides for KCNQ2
     antibodies-online proteins for KCNQ2 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KCNQ2 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4