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Aliases for KCNN4 Gene

Aliases for KCNN4 Gene

  • Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 4 2 3
  • KCA4 3 4 6
  • SK4 3 4 6
  • Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 4 2 3
  • Small Conductance Calcium-Activated Potassium Channel 4 2 3
  • Putative Gardos Channel 3 4
  • SKCa 4 3 4
  • KCa3.1 3 4
  • IKCA1 3 4
  • SKCa4 3 4
  • IK1 3 4
  • Putative Erythrocyte Intermediate Conductance Calcium-Activated Potassium Gardos Channel 3
  • Intermediate Conductance Calcium-Activated Potassium Channel Protein 4 3
  • Intermediate Conductance Calcium-Activated Potassium Channel 2
  • HIKCa1 3
  • HKCa4 3
  • HSK4 3
  • IK 3

External Ids for KCNN4 Gene

Previous GeneCards Identifiers for KCNN4 Gene

  • GC19M044916
  • GC19M044662
  • GC19M048946
  • GC19M048962
  • GC19M044270
  • GC19M040702

Summaries for KCNN4 Gene

Entrez Gene Summary for KCNN4 Gene

  • The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNN4 Gene

KCNN4 (Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 4) is a Protein Coding gene. Diseases associated with KCNN4 include diamond-blackfan anemia. Among its related pathways are Transmission across Chemical Synapses and Salivary secretion. GO annotations related to this gene include calmodulin binding and calcium-activated potassium channel activity. An important paralog of this gene is KCNN1.

UniProtKB/Swiss-Prot for KCNN4 Gene

  • Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.

Tocris Summary for KCNN4 Gene

  • Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes, SK, IK and BK channels, based on their conductance (small, intermediate and big conductance respectively). The small conductance KCa channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both play important roles in many processes involving Ca2+-dependent signalling in both electrically excitable and non-excitable cells. The BK family of KCa channels (also known as Slo or Maxi-K channels) are also voltage-sensitive and include KCa1.1 (Slo1), KCa4.1 (Slo2.2), KCa4.2 (Slo2.1) and KCa5.1 (Slo3). These channels do not require calmodulin for activation as they contain three direct bivalent cation binding sites.

Gene Wiki entry for KCNN4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNN4 Gene

Genomics for KCNN4 Gene

Regulatory Elements for KCNN4 Gene

Genomic Location for KCNN4 Gene

Start:
43,766,533 bp from pter
End:
43,782,117 bp from pter
Size:
15,585 bases
Orientation:
Minus strand

Genomic View for KCNN4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNN4 Gene

Proteins for KCNN4 Gene

  • Protein details for KCNN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15554-KCNN4_HUMAN
    Recommended name:
    Intermediate conductance calcium-activated potassium channel protein 4
    Protein Accession:
    O15554
    Secondary Accessions:
    • Q53XR4

    Protein attributes for KCNN4 Gene

    Size:
    427 amino acids
    Molecular mass:
    47696 Da
    Quaternary structure:
    • Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6.

neXtProt entry for KCNN4 Gene

Proteomics data for KCNN4 Gene at MOPED

Post-translational modifications for KCNN4 Gene

  • Phosphorylation at His-358 by NDKB activates the channel, and conversely its dephosphorylation by PHPT1 inhibits the channel.
  • Ubiquitination at Lys394
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNN4 Gene

No data available for DME Specific Peptides for KCNN4 Gene

Domains for KCNN4 Gene

Gene Families for KCNN4 Gene

HGNC:
  • KCN :Potassium channels
  • KCa :Voltage-gated ion channels / Potassium channels, calcium-activated
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

O15554

UniProtKB/Swiss-Prot:

KCNN4_HUMAN :
  • O15554
Family:
  • Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily.
genes like me logo Genes that share domains with KCNN4: view

Function for KCNN4 Gene

Molecular function for KCNN4 Gene

GENATLAS Biochemistry: potassium intermediate/small conductance calcium-activated channel,subfamily N,member 4,expressed in T lymphocytes and red cells,also expressed in placenta,prostate,fetal,liver and spleen,pancreas and ovarian tumors
UniProtKB/Swiss-Prot Function: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.
UniProtKB/Swiss-Prot Induction: Up-regulated by phorbol myristate acetate (PMA) and phytohemagglutinin (PHA) in T-cells

Gene Ontology (GO) - Molecular Function for KCNN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005267 potassium channel activity --
GO:0005515 protein binding IPI 12198491
GO:0005516 calmodulin binding IBA --
GO:0015269 calcium-activated potassium channel activity IDA 18796614
GO:0016286 NOT small conductance calcium-activated potassium channel activity IBA --
genes like me logo Genes that share ontologies with KCNN4: view
genes like me logo Genes that share phenotypes with KCNN4: view

Animal Models for KCNN4 Gene

MGI Knock Outs for KCNN4:

miRNA for KCNN4 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KCNN4 Gene

Localization for KCNN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNN4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNN4 Gene COMPARTMENTS Subcellular localization image for KCNN4 gene
Compartment Confidence
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for KCNN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IC 18796614
GO:0016021 integral component of membrane --
GO:0016323 basolateral plasma membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with KCNN4: view

Pathways for KCNN4 Gene

genes like me logo Genes that share pathways with KCNN4: view

Pathways by source for KCNN4 Gene

Gene Ontology (GO) - Biological Process for KCNN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006813 potassium ion transport TAS 9380751
GO:0006816 calcium ion transport IDA 18796614
GO:0006820 anion transport --
GO:0006884 cell volume homeostasis IEA --
genes like me logo Genes that share ontologies with KCNN4: view

Compounds for KCNN4 Gene

(5) Tocris Compounds for KCNN4 Gene

Compound Action Cas Number
Apamin KCa2 channel blocker (small conductance) [24345-16-2]
Iberiotoxin KCa channel blocker (big conductance) [129203-60-7]
Paxilline SERCA ATPase blocker. Also potent BKCa channel blocker [57186-25-1]
TRAM 34 Potent and highly selective KCa3.1 channel blocker [289905-88-0]
UCL 1684 Highly potent blocker of KCa2 [199934-16-2]

(1) HMDB Compounds for KCNN4 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(4) Drugbank Compounds for KCNN4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Clotrimazole
  • Chlotrimazole
23593-75-1 target inhibitor
Halothane
  • 2-Bromo-2-Chloro-1,1,1-Trifluoroethane
151-67-7 target inhibitor
Miconazole
22916-47-8 target inhibitor
Quinine
  • 6'-Methoxycinchonidine
130-95-0 target inhibitor

(15) IUPHAR Ligand for KCNN4 Gene

Ligand Type Action Affinity Pubmed IDs
maurotoxin Pore Blocker Inhibition 9
TRAM-34 Pore Blocker Inhibition 8
methyl 4-[4-chloro-3-(trifluoromethyl)phenyl]-6-methyl-3-oxo-1,4,7-tetrahydroisobenzofuran-5-carboxylate Pore Blocker Inhibition 8
ICA-17043 Pore Blocker Inhibition 7.96
nitrendipine Pore Blocker Inhibition 7.57
charybdotoxin-GLU32 analog Pore Blocker Inhibition 7.48
SKA-31 Activator None 6.6
DC-EBIO Activator Agonist 4.9
chlorzoxazone Activator Agonist 4
charybdotoxin Inhibitor None
NS309 Activator Agonist
clotrimazole Channel blocker None
Ca2+ Antagonist Antagonist
riluzole Activator None
EBIO Activator Agonist

(14) Novoseek inferred chemical compound relationships for KCNN4 Gene

Compound -log(P) Hits PubMed IDs
clotrimazole 91.3 12
1-ethyl-2-benzimidazolinone 89.6 6
1-[(2-chlorophenyl)diphenylmethyl]-1h-pyrazole 85.3 1
charybdotoxin 81.3 5
phosphatidylinositol 3-phosphate 63.2 6
genes like me logo Genes that share compounds with KCNN4: view

Transcripts for KCNN4 Gene

Unigene Clusters for KCNN4 Gene

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNN4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - - -
SP2: - - -
SP3:
SP4: - - - - - - -
SP5: -
SP6:
SP7: -
SP8: -

Relevant External Links for KCNN4 Gene

GeneLoc Exon Structure for
KCNN4
ECgene alternative splicing isoforms for
KCNN4

Expression for KCNN4 Gene

mRNA expression in normal human tissues for KCNN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNN4 Gene

This gene is overexpressed in Minor Salivary Gland (9.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCNN4 Gene

SOURCE GeneReport for Unigene cluster for KCNN4 Gene Hs.10082

mRNA Expression by UniProt/SwissProt for KCNN4 Gene

O15554-KCNN4_HUMAN
Tissue specificity: Widely expressed in non-excitable tissues
genes like me logo Genes that share expressions with KCNN4: view

Orthologs for KCNN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNN4 35
  • 99.47 (n)
  • 99.2 (a)
KCNN4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNN4 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNN4 35
  • 89.12 (n)
  • 90.85 (a)
KCNN4 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnn4 35
  • 86.16 (n)
  • 87.74 (a)
Kcnn4 16
Kcnn4 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNN4 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnn4 35
  • 84.63 (n)
  • 86.76 (a)
lizard
(Anolis carolinensis)
Reptilia KCNN4 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732300 35
  • 59.46 (n)
  • 53.32 (a)
zebrafish
(Danio rerio)
Actinopterygii KCNN4 36
  • 42 (a)
OneToOne
LOC568363 35
  • 56.5 (n)
  • 50.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta SK 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kcnl-1 36
  • 17 (a)
ManyToMany
kcnl-2 36
  • 21 (a)
ManyToMany
kcnl-3 36
  • 17 (a)
ManyToMany
kcnl-4 36
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for KCNN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNN4 Gene

ENSEMBL:
Gene Tree for KCNN4 (if available)
TreeFam:
Gene Tree for KCNN4 (if available)

Paralogs for KCNN4 Gene

Paralogs for KCNN4 Gene

Selected SIMAP similar genes for KCNN4 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with KCNN4: view

Variants for KCNN4 Gene

Sequence variations from dbSNP and Humsavar for KCNN4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7181 -- 43,766,773(-) GACTC(C/T)TGGGT utr-variant-3-prime
rs11351 -- 43,766,914(+) GGCCT(A/C)CCCAC utr-variant-3-prime
rs12427 -- 43,766,667(-) GGGGC(C/T)GGAGG utr-variant-3-prime
rs347516 -- 43,766,597(+) CTCCC(C/G/T)ACCAG utr-variant-3-prime
rs347518 -- 43,768,036(+) CATTA(A/G)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNN4 Gene

Variant ID Type Subtype PubMed ID
nsv833839 CNV Loss 17160897
nsv509745 CNV Insertion 20534489
esv2718612 CNV Deletion 23290073

Relevant External Links for KCNN4 Gene

HapMap Linkage Disequilibrium report
KCNN4
Human Gene Mutation Database (HGMD)
KCNN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNN4 Gene

Disorders for KCNN4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for KCNN4 Gene including...

Search for KCNN4 Gene in MalaCards »

(5) Novoseek inferred disease relationships for KCNN4 Gene

Disease -log(P) Hits PubMed IDs
sickle cell disease 59 2
erythroleukemia 39.1 1
hyperplasia 0.785 2
rheumatoid arthritis 0 1
tumors 0 1

Relevant External Links for KCNN4

Genetic Association Database (GAD)
KCNN4
Human Genome Epidemiology (HuGE) Navigator
KCNN4
genes like me logo Genes that share disorders with KCNN4: view

No data available for UniProtKB/Swiss-Prot for KCNN4 Gene

Publications for KCNN4 Gene

  1. hSK4, a member of a novel subfamily of calcium-activated potassium channels. (PMID: 9380751) Joiner W.J. … Kaczmarek L.K. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes. (PMID: 9407042) Logsdon N.J. … Aiyar J. (J. Biol. Chem. 1997) 2 3 4 23
  3. Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences. (PMID: 10961988) Ghanshani S. … Chandy K.G. (J. Biol. Chem. 2000) 3 4 23
  4. Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1. (PMID: 10026195) Fanger C.M. … Aiyar J. (J. Biol. Chem. 1999) 3 4 23
  5. Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. (PMID: 11425865) Wulff H. … Chandy K.G. (J. Biol. Chem. 2001) 3 4 23

Products for KCNN4 Gene

Sources for KCNN4 Gene

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