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KCNN4 Gene

protein-coding   GIFtS: 66
GCID: GC19M044270

Potassium Intermediate/Small Conductance Calcium-Activated...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Intermediate/Small Conductance Calcium-Activated Channel,
Subfamily N, Member 41 2
     SKCa 42 3
KCA42 3 5     hIKCa12
SK42 3 5     hKCa42
Putative Gardos Channel2 3     hSK42
IK12 3     Intermediate Conductance Calcium-Activated Potassium Channel Protein 42
IKCA12 3     Putative Erythrocyte Intermediate Conductance Calcium-Activated Potassium
Gardos Channel2
KCa3.12 3     IKCa13
SKCa42 3     KCa43

External Ids:    HGNC: 62931   Entrez Gene: 37832   Ensembl: ENSG000001047837   OMIM: 6027545   UniProtKB: O155543   

Export aliases for KCNN4 gene to outside databases

Previous GC identifers: GC19M044916 GC19M044662 GC19M048946 GC19M048962 GC19M040702


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNN4 Gene:
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel
that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes
calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in
T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to
possibly be considered as part of a new subfamily. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNN4 Gene:
KCNN4 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4) is a protein-coding gene. GO annotations related to this gene include calmodulin binding and calcium-activated potassium channel activity. An important paralog of this gene is KCNN2.

UniProtKB/Swiss-Prot: KCNN4_HUMAN, O15554
Function: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is
followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and
proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin
but is insensitive to apamin

summary for KCNN4 Gene:
Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+
ions across biological membranes. They are broadly classified into three subtypes, SK, IK and BK channels,
based on their conductance (small, intermediate and big conductance respectively). The small conductance KCa
channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance
KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both
play important roles in many processes involving Ca2+-dependent signalling in both electrically excitable
and non-excitable cells. The BK family of KCa channels (also known as Slo or Maxi-K channels) are also
voltage-sensitive and include KCa1.1 (Slo1), KCa4.1 (Slo2.2), KCa4.2 (Slo2.1) and KCa5.1 (Slo3). These
channels do not require calmodulin for activation as they contain three direct bivalent cation binding
sites.

Gene Wiki entry for KCNN4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNN4 gene promoter:
         Egr-3   p53   AP-1   ATF-2   NRSF form 1   c-Jun   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNN4 promoter sequence
   Search Chromatin IP Primers for KCNN4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.2

KCNN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNN4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M044270:  view genomic region     (about GC identifiers)

Start:
44,270,685 bp from pter      End:
44,285,409 bp from pter
Size:
14,725 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KCNN4_HUMAN, O15554 (See protein sequence)
Recommended Name: Intermediate conductance calcium-activated potassium channel protein 4  
Size: 427 amino acids; 47696 Da
Subunit: Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6
Secondary accessions: Q53XR4

Explore the universe of human proteins at neXtProt for KCNN4: NX_O15554

Explore proteomics data for KCNN4 at MOPED

Post-translational modifications: 

  • Phosphorylation at His-358 by NDKB activates the channel, and conversely it's dephosphorylation by PHPT1 inhibits
    the channel1
  • Ubiquitination2 at Lys394
  • Modification sites at PhosphoSitePlus

  • See KCNN4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002241.1  
    ENSEMBL proteins: 
     ENSP00000470339   ENSP00000262888   ENSP00000471900   ENSP00000472513   ENSP00000472510  
    Reactome Protein details: O15554

    KCNN4 Human Recombinant Protein Products:

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    Novus Biologicals KCNN4 Protein
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    Cloud-Clone Corp. Proteins for KCNN4

     
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    antibodies-online proteins for KCNN4 

     
    antibodies-online peptides for KCNN4

    KCNN4 Antibody Products:

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    ThermoFisher Antibodies for KCNN4
    antibodies-online antibodies for KCNN4 (50 products) 

    KCNN4 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels
    KCa: Voltage-gated ion channels / Potassium channels, calcium-activated

    IUPHAR Guide to PHARMACOLOGY protein family classification: KCa3.1
    Calcium-activated potassium channels

    3 InterPro protein domains:
     IPR004178 CaM-bd_dom
     IPR015449 K_chnl_Ca-activ_SK
     IPR013099 2pore_dom_K_chnl_dom

    Graphical View of Domain Structure for InterPro Entry O15554

    ProtoNet protein and cluster: O15554

    3 Blocks protein domains:
    IPB004178 Calmodulin binding domain
    IPB011996 SK channel region
    IPB013099 Ion transport 2


    UniProtKB/Swiss-Prot: KCNN4_HUMAN, O15554
    Similarity: Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily


    Find genes that share domains with KCNN4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNN4_HUMAN, O15554
    Function: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is
    followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and
    proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin
    but is insensitive to apamin
    Induction: Up-regulated by phorbol myristate acetate (PMA) and phytohemagglutinin (PHA) in T-cells

         Genatlas biochemistry entry for KCNN4:
    potassium intermediate/small conductance calcium-activated channel,subfamily N,member 4,expressed in T lymphocytes
    and red cells,also expressed in placenta,prostate,fetal,liver and spleen,pancreas and ovarian tumors

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005267potassium channel activity ----
    GO:0005515protein binding IPI12198491
    GO:0005516calmodulin binding IEA--
    GO:0015269calcium-activated potassium channel activity IDA18796614
    GO:0016286small conductance calcium-activated potassium channel activity IEA--
         
    Find genes that share ontologies with KCNN4           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Kcnn4):
     cardiovascular system  digestive/alimentary  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  muscle  renal/urinary system 

    Find genes that share phenotypes with KCNN4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for KCNN4: Kcnn4tm1Jemn Kcnn4tm1Rklr Kcnn4tm1.1Jele

       genOway: Develop your customized and physiologically relevant rodent model for KCNN4

    miRNA
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    miRTarBase miRNAs that target KCNN4:
    hsa-mir-16-5p (MIRT001448), hsa-mir-1 (MIRT024000), hsa-mir-375 (MIRT019994), hsa-mir-30a-5p (MIRT028637)

    Block miRNA regulation of human, mouse, rat KCNN4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCNN4 (see all 14):
    hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-15a hsa-miR-497 hsa-miR-1184 hsa-miR-424 hsa-miR-591 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidKCNN4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KCNN4

    Gene Editing
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    OriGene ORF clones in mouse, rat for KCNN4
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    GenScript: all cDNA clones in your preferred vector: KCNN4 (NM_002250)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCNN4_HUMAN, O15554: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IC18796614
    GO:0016021integral component of membrane ----
    GO:0016323basolateral plasma membrane IEA--
    GO:0016324apical plasma membrane IEA--

    Find genes that share ontologies with KCNN4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNN4 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters outward current0.41
    2Insulin secretion
    Insulin secretion0.36
    Ca2+ activated K+ channels0.00
    3Transmission across Chemical Synapses
    Neuronal System0.68
    4Salivary secretion
    Salivary secretion0.34
    5Protein digestion and absorption
    Protein digestion and absorption


    Find genes that share SuperPaths with KCNN4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for KCNN4
        CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

    1 Reactome Pathway for KCNN4
        Ca2+ activated K+ channels


    3 Kegg Pathways  (Kegg details for KCNN4):
        Insulin secretion
    Salivary secretion
    Protein digestion and absorption

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNN4
    Interactions:

        GeneGlobe Interaction Network for KCNN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for KCNN4 (O155543 ENSP000002628884) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=4 STRING: ENSP00000349467
    CALM2P621583I2D: score=4 
    CALM3P621583I2D: score=4 
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    PRKAG1P546193, ENSP000003238674I2D: score=1 STRING: ENSP00000323867
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002376immune system process IEA--
    GO:0006813potassium ion transport TAS9380751
    GO:0006816calcium ion transport IDA18796614
    GO:0006820anion transport ----
    GO:0006884cell volume homeostasis IEA--

    Find genes that share ontologies with KCNN4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNN4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PaxillineSERCA ATPase blocker. Also potent BKCa channel blocker[57186-25-1]
    TRAM 34Highly selective KCa3.1 channel blocker[289905-88-0]
    CyPPAActivator of KCa2.2 and KCa2.3 channels[73029-73-9]
    ApaminKCa2 channel blocker (small conductance)[24345-16-2]
    IberiotoxinKCa channel blocker (big conductance)[129203-60-7]

    1 HMDB Compound for KCNN4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    4 DrugBank Compounds for KCNN4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Halothane2-Bromo-2-Chloro-1,1,1-Trifluoroethane (see all 14)151-67-7targetinhibitor17139284 10794813 17016423
    ClotrimazoleChlotrimazole (see all 2)23593-75-1targetinhibitor8636434 11752352
    Miconazole-- 22916-47-8targetinhibitor8760033 1376313
    Quinine6'-Methoxycinchonidine (see all 6)130-95-0targetinhibitor11752352

    Selected IUPHAR Ligands for KCNN4 (KCa3.1) (see all 15)    About this table
    LigandTypeActionAffinityPubmed IDs
    maurotoxin
    Pore BlockerInhibition912527813
    charybdotoxin
    Pore BlockerInhibition8.52 - 8.6710961988
    TRAM-34
    Pore BlockerInhibition7.6 - 810884437 12939222
    methyl 4-[4-chloro-3-(trifluoromethyl)phenyl]-6-methyl-3-oxo-1,4,7-tetrahydroisobenzofuran-5-carboxylate
    Pore BlockerInhibition7.92 - 815379997 15603962
    NS309
    ActivatorAgonist815471565
    ICA-17043
    Pore BlockerInhibition7.9612433690
    nitrendipine
    Pore BlockerInhibition7.579730970
    charybdotoxin-GLU32 analog
    Pore BlockerInhibition7.4810625664
    clotrimazole
    Pore BlockerInhibition7.1610884437 9326665 9693050 9407042
    Ca2+
    ActivatorAgonist6.1 - 77505804 9326665 9407042 10712246 9380751

    Selected Novoseek inferred chemical compound relationships for KCNN4 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    clotrimazole 91.3 18 11425865 (2), 15241346 (2), 16766578 (1), 10519135 (1) (see all 10)
    1-ethyl-2-benzimidazolinone 89.6 13 16766578 (3), 15241346 (3)
    1-[(2-chlorophenyl)diphenylmethyl]-1h-pyrazole 85.3 1 15662023 (1)
    charybdotoxin 81.3 7 15662023 (1), 17310992 (1), 15208030 (1), 11425865 (1) (see all 5)
    phosphatidylinositol 3-phosphate 63.2 16 16251351 (4), 15831468 (2)
    potassium 59.8 18 9407042 (3), 11425865 (3), 19270724 (2), 9380751 (2) (see all 11)
    iberiotoxin 49.3 1 15662023 (1)
    ionomycin 41.7 1 14600080 (1)
    chloride 35.7 1 16251351 (1)
    tetraethylammonium 31.9 1 11425865 (1)



    Find genes that share compounds with KCNN4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCNN4 gene: 
    NM_002250.2  

    Unigene Cluster for KCNN4:

    Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
    Hs.10082  [show with all ESTs]
    Unigene Representative Sequence: NM_002250
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600909 ENST00000262888(uc002oxl.3) ENST00000598836 ENST00000597184
    ENST00000599720 ENST00000601549 ENST00000600408 ENST00000599107
    miRNA
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    hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-15a hsa-miR-497 hsa-miR-1184 hsa-miR-424 hsa-miR-591 hsa-miR-3143
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      QuantiTect SYBR Green Assays in human, mouse, rat KCNN4
      QuantiFast Probe-based Assays in human, mouse, rat KCNN4

    Additional mRNA sequence: 

    AB128983.1 AB128984.1 AB128985.1 AF000972.1 AF022150.1 AF022797.1 AF033021.1 AF053403.1 
    AF395661.1 BC015337.1 BT007426.1 

    7 DOTS entries:

    DT.441715  DT.97842628  DT.121463297  DT.100801472  DT.40133113  DT.97833328  DT.100801466 

    Selected AceView cDNA sequences (see all 148):

    BQ962741 AF022150 BX417280 BC015337 BP350966 CD723925 CR617778 CR598085 
    CR626849 AI687011 AW089601 AI467982 BM825707 BM707162 BQ679375 BM709501 
    BX340406 BX381030 BM716240 AF000972 BG284696 CB959502 BM825538 BT007426 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KCNN4 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b
    SP1:                                                                                -     -                       -               
    SP2:                                                                                -     -                       -               
    SP3:                                                                                                                              
    SP4:                          -     -     -     -     -                             -     -                                       
    SP5:                                                                                      -                                       


    ECgene alternative splicing isoforms for KCNN4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNN4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCACCCCCA
    KCNN4 Expression
    About this image


    KCNN4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Thymus (Hematopoietic System)
             Thymus
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Placenta (Extraembryonic Tissues)
    KCNN4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNN4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.10082

    UniProtKB/Swiss-Prot: KCNN4_HUMAN, O15554
    Tissue specificity: Widely expressed in non-excitable tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KCNN4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnn41 , 5 potassium intermediate/small conductance calcium-activated more1, 5 86.16(n)1
    87.74(a)1
      7 (10.37 cM)5
    165341  NM_001163510.11  NP_001156982.11 
     243702635 
    lizard
    (Anolis carolinensis)
    Reptilia KCNN46
    potassium intermediate/small conductance calcium-a...
    57(a)
    1 ↔ 1
    LGf(33570-51010)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017323001 intermediate conductance calcium-activated potassium more 59.46(n)
    53.32(a)
      101732300  XM_004916395.1  XP_004916452.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5683631 small conductance calcium-activated potassium channel more 56.5(n)
    50.36(a)
      568363  XM_691690.6  XP_696782.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta SK6
    small conductance calcium-activated potassium chan...
    18(a)
    1 → many
    X(5234269-5298760)
    worm
    (Caenorhabditis elegans)
    Secernentea kcnl-46
    kcnl-26
    (see all 4)
    Protein KCNL-2, isoform g
    (see all 4)
    22(a)
    21(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    V(14531115-14542893) WBGene00008265
    I(8177260-8208740) WBGene00008570


    ENSEMBL Gene Tree for KCNN4 (if available)
    TreeFam Gene Tree for KCNN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNN4 gene
    KCNN22  KCNN12  KCNN32  
    5 SIMAP similar genes for KCNN4 using alignment to 8 protein entries:     KCNN4_HUMAN (see all proteins):
    KCNN2    KCNN3    SK3    KCNN1    KCNQ3

    Find genes that share paralogs with KCNN4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNN4 (see all 542)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1512429731,2
    --44270225(+) GGAGGC/TGGAGG 1 -- ds50010--------
    rs1404649971,2
    --44270273(+) TGGGTA/GACAGA 1 -- ds50010--------
    rs1931074651,2
    --44270354(+) GGGCTA/TCTCCA 1 -- ds50010--------
    rs1135413541,2
    C,F--44270542(+) GGGACT/CGTTGC 1 -- ds50012Minor allele frequency- C:0.04CSA NA 122
    rs108537671,2
    C,A,H--44270567(+) CCTACT/AGAGTT 1 -- ds50016Minor allele frequency- A:0.42NA WA EA 368
    rs1842567071,2
    C--44270642(+) ACGGTC/TTGCCA 1 -- ds50010--------
    rs3475161,2
    C--44270749(+) CTCCCC/G/TACCAG 2 -- ut31 trp32MN NA 186
    rs772035341,2
    C,F--44270809(+) GGGGGC/TGCCAC 1 -- ut311Minor allele frequency- T:0.11WA 118
    rs1892552511,2
    --44270810(+) GGGGCA/GCCACC 1 -- ut310--------
    rs124271,2
    C,F,A,H--44270819(-) GGGGCT/CGGAGG 1 -- ut31 ese315Minor allele frequency- C:0.09MN NS EA WA NA CSA 1896

    HapMap Linkage Disequilibrium report for KCNN4 (44270685 - 44285409 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KCNN4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718612CNV Deletion23290073
    nsv509745CNV Insertion20534489
    nsv833839CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for KCNN4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602754    OMIM disorders: --


    Find genes that share disorders with KCNN4           About GenesLikeMe

    5 Novoseek inferred disease relationships for KCNN4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sickle cell disease 59 2 11425865 (1), 10884437 (1)
    erythroleukemia 39.1 1 14600080 (1)
    hyperplasia 0.785 2 17310992 (1), 16209944 (1)
    rheumatoid arthritis 0 1 10884437 (1)
    tumors 0 1 15662023 (1)

    Genetic Association Database (GAD): KCNN4
    Human Genome Epidemiology (HuGE) Navigator: KCNN4 (2 documents)

    Export disorders for KCNN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNN4 gene, integrated from 10 sources (see all 128):
    (articles sorted by number of sources associating them with KCNN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hSK4, a member of a novel subfamily of calcium-activated potassium channels. (PubMed id 9380751)1, 2, 3, 9 Joiner W.J.... Kaczmarek L.K. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes. (PubMed id 9407042)1, 2, 3, 9 Logsdon N.J.... Aiyar J. (J. Biol. Chem. 1997)
    3. Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. (PubMed id 11425865)1, 2, 9 Wulff H.... Chandy K.G. (J. Biol. Chem. 2001)
    4. Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences. (PubMed id 10961988)1, 2, 9 Ghanshani S.... Chandy K.G. (J. Biol. Chem. 2000)
    5. Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1. (PubMed id 10026195)1, 2, 9 Fanger C.M.... Aiyar J. (J. Biol. Chem. 1999)
    6. KCNN4 gene variant is associated with ileal Crohn's Disease in the Australian and New Zealand population. (PubMed id 20407432)1, 4 Simms L.A....Radford-Smith G.L. (Am. J. Gastroenterol. 2010)
    7. Relationship between haplotypes of KCNN4 gene and susceptibility to human vascular diseases in Japanese. (PubMed id 19644414)1, 4 Yamaguchi M....Mizutani T. (Med. Sci. Monit. 2009)
    8. Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1. (PubMed id 18796614)1, 2 Srivastava S....Skolnik E.Y. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells. (PubMed id 17157250)1, 2 Srivastava S.... Skolnik E.Y. (Mol. Cell 2006)
    10. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (PubMed id 16382103)1, 3 Wei A.D....Wulff H. (Pharmacol. Rev. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3783 HGNC: 6293 AceView: KCNN4 Ensembl:ENSG00000104783 euGenes: HUgn3783
    ECgene: KCNN4 Kegg: 3783 H-InvDB: KCNN4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KCNN4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KCNN4 gene:
    Search GeneIP for patents involving KCNN4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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