Aliases for KCNN4 Gene
- Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 4 2 3
- KCA4 3 4 6
- SK4 3 4 6
- Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 4 2 3
- Small Conductance Calcium-Activated Potassium Channel 4 2 3
- Putative Gardos Channel 3 4
- SKCa 4 3 4
- KCa3.1 3 4
- IKCA1 3 4
- SKCa4 3 4
External Ids for KCNN4 Gene
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNN4 Gene
KCNN4 (Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 4) is a Protein Coding gene. Diseases associated with KCNN4 include diamond-blackfan anemia. Among its related pathways are Transmission across Chemical Synapses and Salivary secretion. GO annotations related to this gene include calmodulin binding and calcium-activated potassium channel activity. An important paralog of this gene is KCNN1.
UniProtKB/Swiss-Prot for KCNN4 Gene
Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.
Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes, SK, IK and BK channels, based on their conductance (small, intermediate and big conductance respectively). The small conductance KCa channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both play important roles in many processes involving Ca2+-dependent signalling in both electrically excitable and non-excitable cells. The BK family of KCa channels (also known as Slo or Maxi-K channels) are also voltage-sensitive and include KCa1.1 (Slo1), KCa4.1 (Slo2.2), KCa4.2 (Slo2.1) and KCa5.1 (Slo3). These channels do not require calmodulin for activation as they contain three direct bivalent cation binding sites.