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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNN4 Gene

protein-coding   GIFtS: 62
GCID: GC19M044270

potassium intermediate/small conductance calcium-activated...
 Explore 25 diseases affiliated with
KCNN4 via
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Biological research products
for KCNN4    

Aliases
for KCNN4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Potassium Intermediate/Small Conductance Calcium-Activated Channel,
Subfamily N, Member 41 2
     IK12 3
KCa3.11 2 3     IKCA12 3
KCA42 3 5     SKCa42 3
SK42 3 5     SKCa 42 3
HIKCa11     Intermediate Conductance Calcium-Activated Potassium Channel Protein 42
HKCa41     Putative Erythrocyte Intermediate Conductance Calcium-Activated Potassium
Gardos Channel2
HSK41     IKCa13
Putative Gardos Channel2 3     KCa43

External Ids:    HGNC: 62931   Entrez Gene: 37832   Ensembl: ENSG000001047837   OMIM: 6027545   UniProtKB: O155543   

Export aliases for KCNN4 gene to outside databases

Previous GC identifers: GC19M044916 GC19M044662 GC19M048946 GC19M048962 GC19M040702


Summaries
for KCNN4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KCNN4:
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that
is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium
influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This
gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part
of a new subfamily. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCNN4_HUMAN, O15554
Function: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is
followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and
proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but
is insensitive to apamin

summary for KCNN4:
Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+
ions across biological membranes. They are broadly classified into three subtypes, SK, IK and BK channels,
based on their conductance (small, intermediate and big conductance respectively). The small conductance KCa
channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance
KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both
play important roles in many processes involving Ca2+-dependent signalling in both electrically excitable
and non-excitable cells. The BK family of KCa channels (also known as Slo or Maxi-K channels) are also
voltage-sensitive and include KCa1.1 (Slo1), KCa4.1 (Slo2.2), KCa4.2 (Slo2.1) and KCa5.1 (Slo3). These
channels do not require calmodulin for activation as they contain three direct bivalent cation binding
sites.

Gene Wiki entry for KCNN4


Genomic Views
for KCNN4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNN4 gene promoter:
         Egr-3   p53   AP-1   ATF-2   NRSF form 1   c-Jun   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNN4 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNN4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.2

KCNN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNN4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M044270:  view genomic region     (about GC identifiers)

Start:
 44,270,685 bp from pter      End:
 44,285,409 bp from pter
Size:
 14,725 bases      Orientation:
 minus strand

Proteins
for KCNN4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCNN4_HUMAN, O15554 (See protein sequence)
Recommended Name: Intermediate conductance calcium-activated potassium channel protein 4  
Size: 427 amino acids; 47696 Da
Subunit: Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q53XR4

Explore the universe of human proteins at neXtProt for KCNN4: NX_O15554

Post-translational modifications:

  • Phosphorylation at His-358 by NDKB activates the channel, and conversely it's dephosphorylation by PHPT1 inhibits the
    • channel1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15554

    • KCNN4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002241.1  
    ENSEMBL proteins: 
     ENSP00000262888  
    Reactome Protein details: O15554
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate: KCNN4
    OriGene Custom Protein Services for KCNN4 
    GenScript Custom Purified and Recombinant Proteins Services for KCNN4
    Novus Biologicals KCNN4 Protein
    Novus Biologicals KCNN4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KCNN4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IC18796614


    KCNN4 for ontologies           About GeneDecksing



    KCNN4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNN4
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    Uscn Antibodies for KCNN4
    Search ThermoFisher Antibodies for KCNN4

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    Uscn ELISAs and CLIAs for KCNN4

    Protein Domains /
    Families
    for KCNN4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCNN4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR004178 CaM-bd_dom
     IPR015449 K_chnl_Ca-activ_SK
     IPR013099 Ion_trans_2

    Graphical View of Domain Structure for InterPro Entry O15554

    ProtoNet protein and cluster: O15554

    3 Blocks protein families:
    IPB004178 Calmodulin binding domain
    IPB011996 SK channel region
    IPB013099 Ion transport 2


    UniProtKB/Swiss-Prot: KCNN4_HUMAN, O15554
    Similarity: Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily


    Function
    for KCNN4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCNN4_HUMAN, O15554
    Function: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is
    followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and
    proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but
    is insensitive to apamin
    Induction: Up-regulated by phorbol myristate acetate (PMA) and phytohemagglutinin (PHA) in T-cells

         Genatlas biochemistry entry for KCNN4:
    potassium intermediate/small conductance calcium-activated channel,subfamily N,member 4,expressed in T lymphocytes and
    red cells,also expressed in placenta,prostate,fetal,liver and spleen,pancreas and ovarian tumors

    miRNA
    Products:            		miRTarBase miRNAs that target KCNN4:
    hsa-mir-16 (MIRT001448)

    OriGene 3'-UTR Clone: KCNN4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNN4
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNN4 (see all 14):
    hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-15a hsa-miR-497 hsa-miR-1184 hsa-miR-424 hsa-miR-591 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmid: KCNN4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNN4 (see all 7)
    OriGene shRNA RFP: KCNN4
    OriGene siRNA: KCNN4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNN4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for KCNN4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNN4 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNN4 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KCNN4 (NM_002250)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNN4 

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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005267potassium channel activity ----
    GO:0005515protein binding IPI12198491
    GO:0005516calmodulin binding IEA--
    GO:0015269calcium-activated potassium channel activity IDA18796614
    GO:0016286small conductance calcium-activated potassium channel activity IEA--


    KCNN4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for KCNN4: Kcnn4tm1Jemn Kcnn4tm1Rklr Kcnn4tm1.1Jele
         8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Kcnn4):
     cardiovascular system  digestive/alimentary  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  muscle  renal/urinary system 

    KCNN4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KCNN4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Potassium Channels
    		Potassium Channels1.00
    		Potassium transporters: outward current0.42
    2CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
    		CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)1.00
    3Ca2+ activated K+ channels
    		Ca2+ activated K+ channels1.00
    4Protein digestion and absorption
    		Protein digestion and absorption1.00
    5Transmission across Chemical Synapses
    		Neuronal System0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for KCNN4
        Potassium transporters- outward current


    1 GeneGo (Thomson Reuters) Pathway for KCNN4
        CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

    3        Reactome Pathways for KCNN4
        Potassium Channels
    Ca2+ activated K+ channels
    Neuronal System


    2         Kegg Pathways  (Kegg details for KCNN4):
        Salivary secretion
    Protein digestion and absorption


    KCNN4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for KCNN4 (O155543 ENSP000002628884) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=4 STRING: ENSP00000349467
    CALM2P621583I2D: score=4 
    CALM3P621583I2D: score=4 
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    PRKAG1P546193, ENSP000003238674I2D: score=1 STRING: ENSP00000323867
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport TAS9380751
    GO:0006816calcium ion transport IDA18796614
    GO:0006884cell volume homeostasis IEA--
    GO:0006952defense response TAS9407042
    GO:0007268synaptic transmission TAS--


    KCNN4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCNN4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCNN4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNN4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DCEBIOActivates Cl- conductance and hIK1 K+ channels[60563-36-2]
    TRAM 34Highly selective IKCa1 channel blocker[289905-88-0]
    Apamin K+ channel blocker (small conductance, Ca2+-dependent) [24345-16-2]
    4-AminopyridineNon-selective KV channel blocker[504-24-5]

    1 HMDB Compound for KCNN4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    4 DrugBank Compounds for KCNN4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Halothane2-Bromo-2-Chloro-1,1,1-Trifluoroethane (see all 14)151-67-7targetinhibitor17139284 10794813 17016423
    ClotrimazoleChlotrimazole (see all 2)23593-75-1targetinhibitor8636434 11752352
    Miconazole-- 22916-47-8targetinhibitor8760033 1376313
    Quinine6'-Methoxycinchonidine (see all 6)130-95-0targetinhibitor11752352

    10/14 Novoseek chemical compound relationships for KCNN4 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    clotrimazole 91.3 18 11425865 (2), 15241346 (2), 16766578 (1), 10519135 (1) (see all 10)
    1-ethyl-2-benzimidazolinone 89.6 13 16766578 (3), 15241346 (3)
    1-[(2-chlorophenyl)diphenylmethyl]-1h-pyrazole 85.3 1 15662023 (1)
    charybdotoxin 81.3 7 15662023 (1), 17310992 (1), 15208030 (1), 11425865 (1) (see all 5)
    phosphatidylinositol 3-phosphate 63.2 16 16251351 (4), 15831468 (2)
    potassium 59.8 18 9407042 (3), 11425865 (3), 19270724 (2), 9380751 (2) (see all 11)
    iberiotoxin 49.3 1 15662023 (1)
    ionomycin 41.7 1 14600080 (1)
    chloride 35.7 1 16251351 (1)
    tetraethylammonium 31.9 1 11425865 (1)

    Search CenterWatch for drugs/clinical trials and news about KCNN4 

    Transcripts
    for KCNN4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCNN4 gene: 
    NM_002250.2  

    Unigene Cluster for KCNN4:

    Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
    Hs.10082  [show with all ESTs]
    Unigene Representative Sequence: NM_002250
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000262888(uc002oxl.3)

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNN4 (see all 14):
    hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-15a hsa-miR-497 hsa-miR-1184 hsa-miR-424 hsa-miR-591 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmid: KCNN4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNN4 (see all 7)
    OriGene shRNA RFP: KCNN4
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNN4
    Clone
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    Primer
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    Additional cDNA sequence: 

    AB128983.1 AB128984.1 AB128985.1 AF000972.1 AF022150.1 AF022797.1 AF033021.1 AF053403.1 
    AF395661.1 BC015337.1 BT007426.1 

    7 DOTS entries:

    DT.441715  DT.97842628  DT.121463297  DT.100801472  DT.40133113  DT.97833328  DT.100801466 

    24/148 AceView cDNA sequences (see all 148):

    BU751881 AF022797 BP350966 BM716240 AI568711 AI682331 BM825707 AA603035 
    BG284696 AI687011 CA309592 BM756821 BT007426 BX340406 AF053403 CD723925 
    BX339013 CR598085 BC015337 CR617778 BX399027 BQ962741 CR626849 BX364995 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KCNN4 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b
    SP1:                                                                                -     -                       -               
    SP2:                                                                                -     -                       -               
    SP3:                                                                                                                              
    SP4:                          -     -     -     -     -                             -     -                                       
    SP5:                                                                                      -                                       


    ECgene alternative splicing isoforms for KCNN4

    Expression
    for KCNN4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNN4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCACCCCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KCNN4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Yolk SacDefinitive Yolk SacDefinitive Hematopoietic Stem CellsBlood
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)

    See KCNN4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNN4

    SOURCE GeneReport for Unigene cluster: Hs.10082

    UniProtKB/Swiss-Prot: KCNN4_HUMAN, O15554
    Tissue specificity: Widely expressed in non-excitable tissues

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    Orthologs
    for KCNN4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KCNN4 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia KCNN46
    		 --
    		 58(a)
    		 1 ↔ 1
    		 LGf(33570-50992)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5683631 small conductance calcium-activated potassium channel more 56.01(n)
    50.36(a)    		   568363  XM_691690.5  XP_696782.5 
    fruit fly
    (Drosophila melanogaster)    		 Insecta SK6
    		 small conductance calcium-activated potassium chan...
    		 18(a)
    		 1 → many
    		 X(5234269-5298760)
    worm
    (Caenorhabditis elegans)    		 Secernentea kcnl-36
    kcnl-46
    (see all 4)    		 Protein KCNL-4, isoform a
    (see all 4)    		 25(a)
    22(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 X(5390698-5394108)
    V(14531100-14542878)


    ENSEMBL Gene Tree for KCNN4 (if available)
    TreeFam Gene Tree for KCNN4 (if available) 

    Paralogs
    for KCNN4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNN4 gene
    KCNN22  KCNN12  KCNN32  
    5 SIMAP similar genes for KCNN4 using alignment to 8 protein entries:     KCNN4_HUMAN (see all proteins):
    SK2    KCNN2    KCNN3    SK3    KCNN1

    KCNN4 for paralogs           About GeneDecksing



    Genomic Variants
    for KCNN4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/474 NCBI SNPs in KCNN4 are shown (see all 474)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1512429731,2
    		--44270225(+) GGAGGC/TGGAGG 1 -- ds50010--------
    rs1404649971,2
    		--44270273(+) TGGGTA/GACAGA 1 -- ds50010--------
    rs1931074651,2
    		--44270354(+) GGGCTA/TCTCCA 1 -- ds50010--------
    rs1135413541,2
    		--44270542(+) GGGACT/CGTTGC 1 -- ds50012Minor allele frequency- C:0.04CSA NA 122
    rs108537671,2
    		C,A,H,--44270567(+) CCTACT/AGAGTT 1 -- ds50016Minor allele frequency- A:0.42NA WA EA 368
    rs1842567071,2
    		C,--44270642(+) ACGGTC/TTGCCA 1 -- ds50010--------
    rs3475161,2
    		C,--44270749(+) CTCCCC/G/TACCAG 2 -- ut31 trp32MN NA 186
    rs772035341,2
    		C,F,--44270809(+) GGGGGC/TGCCAC 1 -- ut311Minor allele frequency- T:0.11WA 118
    rs1892552511,2
    		--44270810(+) GGGGCA/GCCACC 1 -- ut310--------
    rs124271,2
    		C,F,A,H,--44270819(-) GGGGCT/CGGAGG 1 -- ut31 ese315Minor allele frequency- C:0.09MN NS EA WA NA CSA 1896

    HapMap Linkage Disequilibrium report for KCNN4 (44270685 - 44285409 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KCNN4: --

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    Disorders / Diseases
    for KCNN4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCNN4 for disorders           About GeneDecksing

    OMIM gene information: 602754    OMIM disorders: --

    20/25 diseases for KCNN4 (see all 25):    About MalaCards
    diamond-blackfan anemia    traumatic brain injury    secretory diarrhea    sickle cell disease
    brain injury    sickle cell anemia    polycystic kidney disease    rheumatoid arthritis
    kidney disease    cystic fibrosis    anemia    multiple sclerosis
    vascular disease    diarrhea    arthritis    endometrial cancer
    breast adenocarcinoma    fibrosis    colon cancer    adenocarcinoma

    5 Novoseek disease relationships for KCNN4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sickle cell disease 59 2 11425865 (1), 10884437 (1)
    erythroleukemia 39.1 1 14600080 (1)
    hyperplasia 0.785 2 17310992 (1), 16209944 (1)
    rheumatoid arthritis 0 1 10884437 (1)
    tumors 0 1 15662023 (1)

    Human Genome Epidemiology (HuGE) Navigator: KCNN4 (2 documents)

    Export disorders for KCNN4 gene to outside databases

    Publications
    for KCNN4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNN4 gene, integrated from 9 sources (see all 113):
    (articles sorted by number of sources associating them with KCNN4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. hSK4, a member of a novel subfamily of calcium-activated potassium channels. (PubMed id 9380751)1, 2, 3, 9 Joiner W.J.... Kaczmarek L.K. (1997)
    2. A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes. (PubMed id 9407042)1, 2, 3, 9 Logsdon N.J.... Aiyar J. (1997)
    3. Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. (PubMed id 11425865)1, 2, 9 Wulff H.... Chandy K.G. (2001)
    4. Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences. (PubMed id 10961988)1, 2, 9 Ghanshani S.... Chandy K.G. (2000)
    5. Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1. (PubMed id 10026195)1, 2, 9 Fanger C.M.... Aiyar J. (1999)
    6. Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1. (PubMed id 18796614)1, 2 Srivastava S....Skolnik E.Y. (2008)
    7. Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells. (PubMed id 17157250)1, 2 Srivastava S....Skolnik E.Y. (2006)
    8. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (PubMed id 16382103)1, 3 Wei A.D....Wulff H. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Human calcium-activated potassium channel gene KCNN4 maps to chromosome 19q13.2 in the region deleted in diamond-blackfan anemia. (PubMed id 9693050)1, 2 Ghanshani S.... Chandy K.G. (1998)

    External Searches for KCNN4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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    Genome Databases showing KCNN4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3783 HGNC: 6293 AceView: KCNN4 Ensembl:ENSG00000104783 euGenes: HUgn3783
    ECgene: KCNN4 Kegg: 3783 H-InvDB: KCNN4

    Other Databases showing KCNN4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCNN4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNN4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCNN4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCNN4 gene:
    Search GeneIP for patents involving KCNN4

    GeneCards and IP:
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