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KCNN3 Gene

protein-coding   GIFtS: 65
GCID: GC01M154669

Potassium Intermediate/Small Conductance Calcium-Activated...

  See KCNN3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Intermediate/Small Conductance Calcium-Activated Channel,
Subfamily N, Member 31 2
     hSK32
SK32 3 5     Small Conductance Calcium-Activated Potassium Channel Protein 32
KCa2.32 3     K33
SKCa 32 3     SKCa33
SKCA32 5     

External Ids:    HGNC: 62921   Entrez Gene: 37822   Ensembl: ENSG000001436037   OMIM: 6029835   UniProtKB: Q9UGI63   

Export aliases for KCNN3 gene to outside databases

Previous GC identifers: GC01M152495 GC01M150410 GC01M151455 GC01M151896 GC01M151492 GC01M152946 GC01M154680 GC01M126042


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNN3 Gene:
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for
several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the
AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs
to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a
voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing
to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was
thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia
or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Feb 2011)

GeneCards Summary for KCNN3 Gene:
KCNN3 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3) is a protein-coding gene. Diseases associated with KCNN3 include bipolar disorder, and schizophrenia. GO annotations related to this gene include small conductance calcium-activated potassium channel activity and calmodulin binding. An important paralog of this gene is KCNN4.

UniProtKB/Swiss-Prot: KCNN3_HUMAN, Q9UGI6
Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed
by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of
synaptic afterhyperpolarization. The channel is blocked by apamin

summary for KCNN3 Gene:
Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+
ions across biological membranes. They are broadly classified into three subtypes, SK, IK and BK channels,
based on their conductance (small, intermediate and big conductance respectively). The small conductance KCa
channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance
KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both
play important roles in many processes involving Ca2+-dependent signalling in both electrically excitable
and non-excitable cells. The BK family of KCa channels (also known as Slo or Maxi-K channels) are also
voltage-sensitive and include KCa1.1 (Slo1), KCa4.1 (Slo2.2), KCa4.2 (Slo2.1) and KCa5.1 (Slo3). These
channels do not require calmodulin for activation as they contain three direct bivalent cation binding
sites.

Gene Wiki entry for KCNN3 (SK3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNN3 gene promoter:
         HEN1   Sp1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNN3 promoter sequence
   Search Chromatin IP Primers for KCNN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

KCNN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNN3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M154669:  view genomic region     (about GC identifiers)

Start:
154,669,931 bp from pter      End:
154,842,756 bp from pter
Size:
172,826 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KCNN3_HUMAN, Q9UGI6 (See protein sequence)
Recommended Name: Small conductance calcium-activated potassium channel protein 3  
Size: 736 amino acids; 82026 Da
Subunit: Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit
which regulates the channel activity through calcium-binding (By similarity)
Secondary accessions: B1ANX0 O43517 Q86VF9 Q8WXG7
Alternative splicing: 3 isoforms:  Q9UGI6-1   Q9UGI6-2   Q9UGI6-3   (Do not produce functional channels, but selectively suppresses endogenous SK3 currents, in a dominant-negative fashion. This dominant inhibitory effect extends to other members of the SK subfamily. Widely distributed in human tissues and is present at 20-60% of SK3 in the brain)

Explore the universe of human proteins at neXtProt for KCNN3: NX_Q9UGI6

Explore proteomics data for KCNN3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys555
  • Modification sites at PhosphoSitePlus

  • See KCNN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001191016.1  NP_002240.3  NP_740752.1  

    ENSEMBL proteins: 
     ENSP00000271915   ENSP00000354764   ENSP00000351295  
    Reactome Protein details: Q9UGI6

    KCNN3 Human Recombinant Protein Products:

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    Novus Biologicals KCNN3 Proteins
    Novus Biologicals KCNN3 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KCNN3

     
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    antibodies-online proteins for KCNN3 (7 products) 

     
    antibodies-online peptides for KCNN3

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    antibodies-online antibodies for KCNN3 (23 products) 

    KCNN3 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels
    KCa: Voltage-gated ion channels / Potassium channels, calcium-activated

    IUPHAR Guide to PHARMACOLOGY protein family classification: KCa2.3
    Calcium-activated potassium channels

    3 InterPro protein domains:
     IPR004178 CaM-bd_dom
     IPR015449 K_chnl_Ca-activ_SK
     IPR013099 2pore_dom_K_chnl_dom

    Graphical View of Domain Structure for InterPro Entry Q9UGI6

    ProtoNet protein and cluster: Q9UGI6

    3 Blocks protein domains:
    IPB004178 Calmodulin binding domain
    IPB011996 SK channel region
    IPB013099 Ion transport 2


    UniProtKB/Swiss-Prot: KCNN3_HUMAN, Q9UGI6
    Similarity: Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily


    Find genes that share domains with KCNN3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNN3_HUMAN, Q9UGI6
    Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed
    by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of
    synaptic afterhyperpolarization. The channel is blocked by apamin

         Genatlas biochemistry entry for KCNN3:
    potassium intermediate/small conductance calcium-activated channel,subfamily N,member 3

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005516calmodulin binding IEA--
    GO:0015269calcium-activated potassium channel activity ----
    GO:0016286small conductance calcium-activated potassium channel activity IEA--
    GO:0046982protein heterodimerization activity ----
         
    Find genes that share ontologies with KCNN3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KCNN3:
     Decreased viability of wild-ty 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Kcnn3):
     mortality/aging  nervous system  no phenotypic analysis  reproductive system  respiratory system 

    Find genes that share phenotypes with KCNN3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kcnn3tm2.2Jpad for KCNN3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNN3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KCNN3

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    Selected qRT-PCR Assays for microRNAs that regulate KCNN3 (see all 195):
    hsa-miR-411* hsa-miR-128 hsa-miR-877* hsa-miR-298 hsa-miR-149 hsa-miR-208b hsa-miR-376a* hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmidKCNN3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNN3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCNN3_HUMAN, Q9UGI6: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    nucleus3
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0030175filopodium ----
    GO:0031594neuromuscular junction ----

    Find genes that share ontologies with KCNN3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNN3 About    
    See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters outward current0.41
    2Insulin secretion
    Insulin secretion0.36
    Ca2+ activated K+ channels0.00
    3Transmission across Chemical Synapses
    Neuronal System0.68
    4Synaptic transmission ion currents
    Synaptic transmission ion currents


    Find genes that share SuperPaths with KCNN3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for KCNN3
        Ca2+ activated K+ channels


    1 Kegg Pathway  (Kegg details for KCNN3):
        Insulin secretion

        Pathway & Disease-focused RT2 Profiler PCR Array including KCNN3: 
              Neuronal Ion Channels in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KCNN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for KCNN3 (Q9UGI63 ENSP000002719154) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    KCNN2ENSP000002647734STRING: ENSP00000264773
    SNAP91ENSP000001956494STRING: ENSP00000195649
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport ----
    GO:0007268synaptic transmission TAS--

    Find genes that share ontologies with KCNN3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNN3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PaxillineSERCA ATPase blocker. Also potent BKCa channel blocker[57186-25-1]
    TRAM 34Highly selective KCa3.1 channel blocker[289905-88-0]
    CyPPAActivator of KCa2.2 and KCa2.3 channels[73029-73-9]
    ApaminKCa2 channel blocker (small conductance)[24345-16-2]
    IberiotoxinKCa channel blocker (big conductance)[129203-60-7]

    1 HMDB Compound for KCNN3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for KCNN3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Miconazole-- 22916-47-8targetinhibitor8760033 1376313

    Selected IUPHAR Ligands for KCNN3 (KCa2.3) (see all 13)    About this table
    LigandTypeActionAffinityPubmed IDs
    apamin
    Pore BlockerAntagonist7.9 - 9.111369031 14978258
    leiurotoxin I
    Pore BlockerAntagonist8.7 - 911527975 14978258
    UCL1684
    Pore BlockerAntagonist811278890
    P05
    Pore BlockerAgonist7.611527975
    Ca2+
    ActivatorAgonist6.49774106 17486140 14978258
    NS8593
    Gating inhibitorAntagonist6.116926279
    Lei-Dab7
    Pore BlockerAgonist5.611527975
    CyPPA
    ActivatorAgonist5.317486140
    DC-EBIO
    ActivatorAgonist4.917584055
    dequalinium chloride
    Pore BlockerAntagonist4.511369031

    9 Novoseek inferred chemical compound relationships for KCNN3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    scyllatoxin 86.9 2 14978258 (1)
    1-ethyl-2-benzimidazolinone 83.7 2 14978258 (1)
    apamin 80.2 6 11245600 (2), 12382077 (1), 17101631 (1), 14978258 (1)
    potassium 66.5 19 10395218 (2), 19472917 (2), 11501944 (1), 12850554 (1) (see all 16)
    d-tubocurarine 49.5 2 14978258 (1)
    glutamine 42.9 5 9866821 (1), 10395218 (1), 11121173 (1), 16162291 (1) (see all 5)
    tetraethylammonium 32.2 3 14978258 (1)
    calcium 4.96 7 11245600 (2), 19472917 (2), 15068253 (1), 16162291 (1) (see all 5)
    h2o2 0 1 16173951 (1)



    Find genes that share compounds with KCNN3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCNN3 gene (3 alternative transcripts): 
    NM_001204087.1  NM_002249.5  NM_170782.2  

    Unigene Cluster for KCNN3:

    Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
    Hs.490765  [show with all ESTs]
    Unigene Representative Sequence: NM_001204087
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000271915(uc021pah.1 uc001ffp.3 uc009wox.1) ENST00000515643
    ENST00000361147(uc001ffo.3) ENST00000358505
    miRNA
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    hsa-miR-411* hsa-miR-128 hsa-miR-877* hsa-miR-298 hsa-miR-149 hsa-miR-208b hsa-miR-376a* hsa-miR-508-5p
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    Additional mRNA sequence: 

    AF031815.1 AF438203.1 AJ251016.1 AK310077.1 AY049734.1 AY138900.1 AY258142.1 BC030100.1 
    BC042147.1 BX649146.1 

    10 DOTS entries:

    DT.410710  DT.410709  DT.91663015  DT.40120086  DT.91726786  DT.100642243  DT.100698840  DT.97770491 
    DT.99959287  DT.100746102 

    Selected AceView cDNA sequences (see all 69):

    AI611826 AA741463 AW575885 AA767647 N47474 BG231908 AA419456 CR595038 
    BE513322 NM_002249 BC042147 CB067998 AW074697 AY138900 NM_170782 AA491238 
    AI201553 AA808321 AU118918 AI813448 AI769660 BX649146 AA775314 AY049734 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KCNN3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b
    SP1:                                                                                          
    SP2:        -     -                                                                           
    SP3:              -                                                                           
    SP4:                                                                    -     -               


    ECgene alternative splicing isoforms for KCNN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    KCNN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KCNN3 Expression
    About this image


    KCNN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Neural Tube (Nervous System)
             Floor plate-like cells
     
     Eye (Sensory Organs)
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    KCNN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.490765
        Pathway & Disease-focused RT2 Profiler PCR Array including KCNN3: 
              Neuronal Ion Channels in human mouse rat

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    OriGene qPCR primer pairs and template standards for KCNN3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNN3
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KCNN3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnn31 , 5 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 less1, 5 89.88(n)1
    93.43(a)1
      3 (39.16 cM)5
    1404931  NM_080466.21  NP_536714.21 
     895201645 
    chicken
    (Gallus gallus)
    Aves KCNN36
    potassium intermediate/small conductance calcium-a...
    94(a)
    1 ↔ 1
    JH375632.1(3770-4323)
    lizard
    (Anolis carolinensis)
    Reptilia KCNN36
    potassium intermediate/small conductance calcium-a...
    93(a)
    1 ↔ 1
    GL344076.1(3888-8189)
    zebrafish
    (Danio rerio)
    Actinopterygii kcnn31 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 less 70.7(n)
    76.59(a)
      570138  XM_001921759.3  XP_001921794.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta SK3 calcium-activated potassium channel 54(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea C03F11.13 noninactivating potassium channel
    (weak)
    37(a)
    (best of 2)
      X(5426007-5429417)   --


    ENSEMBL Gene Tree for KCNN3 (if available)
    TreeFam Gene Tree for KCNN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNN3 gene
    KCNN42  KCNN22  KCNN12  
    5 SIMAP similar genes for KCNN3 using alignment to 3 protein entries:     KCNN3_HUMAN (see all proteins):
    SK3    AAD14    KCNN1    KCNN2    KCNN4

    Find genes that share paralogs with KCNN3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    KCNN3_HUMAN, Q9UGI6: The second poly-Gln region of KCNN3 is highly polymorphic and the number of Gln varies from 12 to 28
    in the population


    Selected SNPs for KCNN3 (see all 3694)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs590122451,2
    C--154672362(+) GGTCT-/AAAAAAA 3 -- ut310--------
    rs715860351,2
    C--154677954(+) GTCCATG/-TGTTT 3 -- ut311Minor allele frequency- -:0.50NA 2
    rs3703665921,2
    C--154686446(+) TGTGT-/ATGTGT 3 -- int10--------
    rs2018292431,2
    C--154687020(+) GTGTG-/GT/TG 
            
    GTGTG
    3 -- int10--------
    rs680519271,2
    C--154687909(+) AAAAAA/-AAAAA 3 -- int11Minor allele frequency- -:0.00NA 2
    rs113470241,2
    C,F--154694862(+) TAGCA-/T/T   
       T
    /TTT
    TTTTT
    6 -- int1 cds1 trp32NA 4
    rs353111811,2
    C--154694881(+) TTTTT-/T/TT  
            
    GAGAT
    3 -- int11NA 2
    rs113624181,2
    C--154697336(+) GATTC-/TTTTTT 3 -- int1 trp30--------
    rs1123754761,2
    C--154698018(+) CCTTCT/CTTCTT 3 -- int11Minor allele frequency- C:0.00CSA 1
    rs113863641,2
    C--154707464(+) GGTGA-/CCCAGG 3 -- int10--------

    HapMap Linkage Disequilibrium report for KCNN3 (154669931 - 154842756 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KCNN3 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718363CNV Deletion23290073
    esv2718350CNV Deletion23290073
    esv2673228CNV Deletion23128226
    esv2574257CNV Insertion19546169
    esv1554680CNV Insertion17803354
    nsv509491CNV Insertion20534489
    nsv2966CNV Insertion18451855
    nsv464073CNV Loss19166990
    nsv470740CNV Gain18288195
    nsv521887CNV Gain19592680

    Human Gene Mutation Database (HGMD): KCNN3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNN3
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602983    OMIM disorders: --

    2 diseases for KCNN3:    
    About MalaCards
    bipolar disorder    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for KCNN3:
    Schizophrenia

    Find genes that share disorders with KCNN3           About GenesLikeMe

    5 Novoseek inferred disease relationships for KCNN3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hirschsprung disease 58.5 2 12778407 (1), 12457234 (1)
    schizophrenia 54.8 32 10395218 (4), 10196711 (4), 16086287 (3), 12898569 (3) (see all 13)
    myotonic dystrophy 50.6 3 12875918 (2), 19472917 (1)
    bipolar disorder 48.2 9 12898569 (3), 11121173 (2), 11311923 (1), 11526470 (1) (see all 6)
    anorexia nervosa 28.8 1 15389773 (1)

    Genetic Association Database (GAD): KCNN3
    Human Genome Epidemiology (HuGE) Navigator: KCNN3 (23 documents)

    Export disorders for KCNN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNN3 gene, integrated from 10 sources (see all 111):
    (articles sorted by number of sources associating them with KCNN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder? (PubMed id 9491810)1, 2, 3 Chandy K.G.... Gargus J.J. (Mol. Psychiatry 1998)
    2. Analysis of Single Nucleotide Polymorphisms (SNPs) of the small-conductance calcium activated potassium channel (SK3) gene as genetic modifier of the cardiac phenotype in myotonic dystrophy type 1 patients. (PubMed id 19472917)1, 4, 9 Rinaldi F....Novelli G. (Acta Myol 2008)
    3. [Transmission disequilibrium analysis of 1137-1140 Del GTGA frameshift mutation within the KCNN3 gene and schizophrenia based on family trios]. (PubMed id 16086287)1, 4, 9 Hong X.H....Wu C.R. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005)
    4. CAG repeat polymorphism within the KCNN3 gene is a significant contributor to susceptibility to anorexia nervosa: a case-control study of female patients and several ethnic groups in the Israeli Jewish population. (PubMed id 15389773)1, 4, 9 Koronyo-Hamaoui M....Weizman A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004)
    5. Schizophrenia and polymorphic CAG repeats array of calcium-activated potassium channel (KCNN3) gene in Serbian population. (PubMed id 16393881)1, 4, 9 IvkoviA8 M....Romac S. (Int. J. Neurosci. 2006)
    6. Novel truncated isoform of SK3 potassium channel is a potent dominant-negative regulator of SK currents: implications in schizophrenia. (PubMed id 12808432)1, 2, 9 Tomita H.... Gargus J.J. (Mol. Psychiatry 2003)
    7. CAG-repeat length in exon 1 of KCNN3 does not influence risk for schizophrenia or bipolar disorder: a meta-analysis of association studies. (PubMed id 12898569)1, 4, 9 Glatt S.J....Tsuang M.T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003)
    8. Association study of CAG repeats in the KCNN3 gene in Israeli patients with major psychosis. (PubMed id 12960745)1, 4, 9 Ritsner M....Navon R. (Psychiatr. Genet. 2003)
    9. Association and linkage studies between bipolar affective disorder and the polymorphic CAG/CTG repeat loci ERDA1, SEF2-1B, MAB21L and KCNN3. (PubMed id 11526470)1, 4, 9 Meira-Lima I.V....Vallada H. (Mol. Psychiatry 2001)
    10. Association analysis of CAG repeats at the KCNN3 locus in Indian patients with bipolar disorder and schizophrenia. (PubMed id 11121173)1, 4, 9 Saleem Q....Jain S. (Am. J. Med. Genet. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3782 HGNC: 6292 AceView: KCNN3 Ensembl:ENSG00000143603 euGenes: HUgn3782
    ECgene: KCNN3 Kegg: 3782 H-InvDB: KCNN3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KCNN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCNN3 gene:
    Search GeneIP for patents involving KCNN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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