KCNN3 Gene
protein-coding GIFtS: 63
GCID: GC01M154680
|
|
potassium intermediate/small conductance calcium-activated...
| |
Aliases
for KCNN3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Potassium Intermediate/Small Conductance Calcium-Activated Channel,Subfamily N, Member 31 2 | | SKCa 32 3 | | KCa2.31 2 3 | | Small Conductance Calcium-Activated Potassium Channel Protein 32 | | SKCA31 2 5 | | K33 | | SK32 3 5 | | SKCa33 | | HSK31 | | |
Export aliases for KCNN3 gene to outside databasesPrevious GC identifers: GC01M152495 GC01M150410 GC01M151455 GC01M151896 GC01M151492 GC01M152946 GC01M126042 |
Summaries
for KCNN3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KCNN3:
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for severalseconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP iskinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNNfamily of potassium channels. It encodes an integral membrane protein that forms a voltage-independentcalcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component ofsynaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of oneor both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studiesindicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoformshave been found for this gene. (provided by RefSeq, Feb 2011)
UniProtKB/Swiss-Prot: KCNN3_HUMAN, Q9UGI6Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed bymembrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component ofsynaptic afterhyperpolarization. The channel is blocked by apamin
 summary
for KCNN3: Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+
ions across biological membranes. They are broadly classified into three subtypes, SK, IK and BK channels,
based on their conductance (small, intermediate and big conductance respectively). The small conductance KCa
channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance
KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both
play important roles in many processes involving Ca2+-dependent signalling in both electrically excitable
and non-excitable cells. The BK family of KCa channels (also known as Slo or Maxi-K channels) are also
voltage-sensitive and include KCa1.1 (Slo1), KCa4.1 (Slo2.2), KCa4.2 (Slo2.1) and KCa5.1 (Slo3). These
channels do not require calmodulin for activation as they contain three direct bivalent cation binding
sites.
Gene Wiki entry for KCNN3 (SK3)
|
Genomic Views
for KCNN3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCNN3 gene promoter:
HEN1 Sp1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCNN3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNN3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.3KCNN3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M154680: view genomic region
(about GC identifiers)
Start:
|
154,679,902 bp from pter |
End:
|
154,842,756 bp from pter |
Size:
|
162,855 bases |
Orientation:
|
minus strand |
|
Proteins
for KCNN3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KCNN3_HUMAN, Q9UGI6 (See
protein sequence)Recommended Name: Small conductance calcium-activated potassium channel protein 3 Size: 736 amino acids; 82026 Da
Subunit: Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunitwhich regulates the channel activity through calcium-binding (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B1ANX0 O43517 Q8WXG7Alternative splicing: 2 isoforms: Q9UGI6-1 Q9UGI6-2 Explore the universe of human proteins at neXtProt for KCNN3: NX_Q9UGI6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UGI6
KCNN3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001191016.1 NP_002240.3 NP_740752.1
ENSEMBL proteins: ENSP00000354764 ENSP00000271915 ENSP00000351295 Reactome Protein details: Q9UGI6
Human Recombinant Protein Products for KCNN3:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
KCNN3 for ontologies About GeneDecksing
KCNN3 Antibody Products:
Assay Products for KCNN3: |
Protein
Domains /
Families
for KCNN3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCNN3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UGI6ProtoNet protein and cluster: Q9UGI6 3 Blocks protein families: IPB004178 Calmodulin binding domain IPB011996 SK channel region IPB013099 Ion transport 2
UniProtKB/Swiss-Prot: KCNN3_HUMAN, Q9UGI6Similarity: Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily |
Function
for KCNN3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: KCNN3_HUMAN, Q9UGI6Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed bymembrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component ofsynaptic afterhyperpolarization. The channel is blocked by apamin Genatlas biochemistry entry for KCNN3:potassium intermediate/small conductance calcium-activated channel,subfamily N,member 3
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005516 | calmodulin binding |
IEA | -- | | GO:0015269 | calcium-activated potassium channel activity |
-- | -- | | GO:0016286 | small conductance calcium-activated potassium channel activity |
IEA | -- |
KCNN3 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for KCNN3:
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Kcnn3):
KCNN3 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Kcnn3tm2.2Jpad for KCNN3
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNN3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNN3 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): KCNN3 (NM_001204087) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNN3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNN3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNN3 |
|
Pathways & Interactions
for KCNN3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Potassium Channels | | | 2 | Ca2+ activated K+ channels | | | 3 | Synaptic transmission: ion currents | | | 4 | Transmission across Chemical Synapses | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for KCNN3
3 
Reactome Pathways for KCNN3
KCNN3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNN3
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/6 Interacting proteins for KCNN3 (Q9UGI63 ENSP000002719154) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007268 | synaptic transmission |
TAS | -- |
KCNN3 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCNN3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
KCNN3 for compounds About GeneDecksing
Compounds for KCNN3 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| UCL 1684 | Highly potent blocker of SKCa | [199934-16-2] | | Apamin | K+ channel blocker (small conductance, Ca2+-dependent) | [24345-16-2] | | 4-Aminopyridine | Non-selective KV channel blocker | [504-24-5] |
1 HMDB Compound for KCNN3 About this table
1 DrugBank Compound for KCNN3 About this table
9 Novoseek chemical compound relationships for KCNN3 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| scyllatoxin |
86.9 |
2 |
14978258 (1) |
| 1-ethyl-2-benzimidazolinone |
83.7 |
2 |
14978258 (1) |
| apamin |
80.2 |
6 |
11245600 (2), 12382077 (1), 17101631 (1), 14978258 (1) |
| potassium |
66.5 |
19 |
10395218 (2), 19472917 (2), 11501944 (1), 12850554 (1) (see all 16) |
| d-tubocurarine |
49.5 |
2 |
14978258 (1) |
| glutamine |
42.9 |
5 |
9866821 (1), 10395218 (1), 11121173 (1), 16162291 (1) (see all 5) |
| tetraethylammonium |
32.2 |
3 |
14978258 (1) |
| calcium |
4.96 |
7 |
11245600 (2), 19472917 (2), 15068253 (1), 16162291 (1) (see all 5) |
| h2o2 |
0 |
1 |
16173951 (1) |
Search CenterWatch for drugs/clinical trials and news about KCNN3
|
Transcripts
for KCNN3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KCNN3 gene (3 alternative transcripts): NM_001204087.1 NM_002249.5 NM_170782.2 Unigene Cluster for KCNN3: Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 Hs.490765 [show with all ESTs]Unigene Representative Sequence: NM_0012040873 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361147(uc001ffo.3) ENST00000271915(uc021pah.1 uc001ffp.3 uc009wox.1)
ENST00000358505
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNN3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNN3 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): KCNN3 (NM_001204087) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNN3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNN3 |
Additional cDNA sequence: AF031815.1 AF438203.1 AJ251016.1 AK310077.1 AY049734.1 AY138900.1 AY258142.1 BC030100.1 BC042147.1 BX649146.1 10 DOTS entries: DT.410710 DT.410709 DT.91663015 DT.40120086 DT.91726786 DT.100642243 DT.100698840 DT.97770491 DT.99959287 DT.100746102 24/69 AceView cDNA sequences (see all 69): AU118918 AI201553 AA808321 AA491238 AA419456 AI769660 BG231908 AW074697 AI611826 NM_170782 CB067998 BC042147 AA741463 AY138900 AW575885 N47474 AA767647 BE513322 AI813448 CR595038 NM_002249 BQ710939 BF306047 AY258142
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for KCNN3 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | |
ECgene alternative splicing isoforms for KCNN3
|
Expression
for KCNN3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KCNN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See KCNN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNN3
SOURCE GeneReport for Unigene cluster: Hs.490765
SABiosciences Expression via Pathway-Focused PCR Array including KCNN3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNN3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNN3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNN3 |
Orthologs
for KCNN3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KCNN3 gene from 4/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
KCNN36 |
-- |
94(a) |
1 ↔ 1 |
GL344076.1(4260-8088) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5701381 |
small conductance calcium-activated potassium channel protein 3-like less |
69.47(n)
74.44(a) |
|
570138 XM_001921759.2 XP_001921794.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
SK1 , 3 |
calcium-activated potassium channel3
small conductance calcium-activated potassium channel less1 |
54(a)3
56.27(n)1
54.29(a)1 |
|
314561 NM_167029.21 NP_726986.31 |
worm
(Caenorhabditis elegans) |
Secernentea |
C03F11.13
kcnl-21 |
noninactivating potassium channel (weak)3
Protein KCNL-21 |
37(a)
(best of 2)3
51.41(n)1
47.18(a)1 |
|
X(5426007-5429417)3
1726021 NM_059833.31 NP_492234.21 |
ENSEMBL Gene Tree for KCNN3 (if available)
TreeFam Gene Tree for KCNN3 (if available) |
Paralogs
for KCNN3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KCNN3 gene
- KCNN42 KCNN22 KCNN12
6 SIMAP similar genes for KCNN3 using alignment to 4 protein entries: KCNN3_HUMAN (see all proteins):SK3 AAD14 KCNN2 KCNN1 SK2 KCNN4
KCNN3 for paralogs About GeneDecksing
|
Genomic Variants
for KCNN3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: KCNN3_HUMAN, Q9UGI6Polymorphism: The second poly-Gln region of KCNN3 is highly polymorphic and the number of Gln varies from 12 to 28 inthe population
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KCNN3 (154679902 - 154842756 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KCNN3
1 CNV: 23272
Human Gene Mutation Database (HGMD): KCNN3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNN3 |
|
Disorders
/ Diseases
for KCNN3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KCNN3 for disorders About GeneDecksing
OMIM gene information: 602983
OMIM disorders: --
20  diseases for KCNN3: About MalaCardsbipolar disorder schizophrenia patent ductus arteriosus myotonic dystrophy
myotonic dystrophy type 1 anorexia nervosa bipolar affective disorder autism spectrum disorder
neuronitis hirschsprung's disease atrial fibrillation schizoaffective disorder
spinocerebellar ataxia muscular dystrophy migraine down syndrome
ataxia medulloblastoma breast cancer melanoma
1 disease from the University of Copenhagen DISEASES database for KCNN3:Schizophrenia 5 Novoseek disease relationships for KCNN3 gene About this table
Genetic Association Database (GAD): KCNN3
Human Genome Epidemiology (HuGE) Navigator: KCNN3 (23 documents)
Export disorders for KCNN3 gene to outside databases
|
Publications
for KCNN3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KCNN3 gene, integrated from 9 sources (see all 99):
(articles sorted by number of sources associating them with KCNN3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder? (PubMed id 9491810)1, 2, 3 Chandy K.G.... Gargus J.J. (1998)
- [Transmission disequilibrium analysis of 1137-1140 Del GTGA frameshift mutation within the KCNN3 gene and schizophrenia based on family trios] (PubMed id 16086287)1, 4, 9 Hong X.H....Wu C.R. (2005)
- CAG repeat polymorphism within the KCNN3 gene is a significant contributor to susceptibility to anorexia nervosa: a case-control study of female patients and several ethnic groups in the Israeli Jewish population. (PubMed id 15389773)1, 4, 9 Koronyo-Hamaoui M....Weizman A. (2004)
- Schizophrenia and polymorphic CAG repeats array of calcium-activated potassium channel (KCNN3) gene in Serbian population. (PubMed id 16393881)1, 4, 9 Ivkovic M....Romac S. (2006)
- CAG-repeat length in exon 1 of KCNN3 does not influence risk for schizophrenia or bipolar disorder: a meta-analysis of association studies. (PubMed id 12898569)1, 4, 9 Glatt S.J....Tsuang M.T. (2003)
- Association study of CAG repeats in the KCNN3 gene in Israeli patients with major psychosis. (PubMed id 12960745)1, 4, 9 Ritsner M....Navon R. (2003)
- Association and linkage studies between bipolar affective disorder and the polymorphic CAG/CTG repeat loci ERDA1, SEF2-1B, MAB21L and KCNN3. (PubMed id 11526470)1, 4, 9 Meira-Lima I.V....Vallada H. (2001)
- Association analysis of CAG repeats at the KCNN3 locus in Indian patients with bipolar disorder and schizophrenia. (PubMed id 11121173)1, 4, 9 Saleem Q....Jain S. (2000)
- Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility. (PubMed id 16162291)1, 4, 9 Curtain R....Griffiths L. (2005)
- CAG repeat polymorphisms in KCNN3 (HSKCa3) and PPP2R2B show no association or linkage to schizophrenia. (PubMed id 12497613)1, 4, 9 Laurent C....Mallet J. (2003)
|
External Searches for KCNN3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCNN3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing KCNN3 gene
(According to HUGE)
About This Section
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Specialized Databases showing KCNN3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for KCNN3 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for KCNN3 gene:
Search GeneIP for patents involving KCNN3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for KCNN3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KCNN3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNN3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNN3 | | | OriGene Protein Over-expression Lysate for KCNN3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KCNN3 | | OriGene 3'-UTR Clone for KCNN3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNN3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNN3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KCNN3 | | OriGene Custom Protein Services for KCNN3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNN3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNN3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNN3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNN3 |
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| | | | Tocris compounds for KCNN3 |
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 | | | KCNN3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNN3 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for KCNN3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNN3 |
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