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Aliases for KCNN3 Gene

Aliases for KCNN3 Gene

  • Potassium Calcium-Activated Channel Subfamily N Member 3 2 3
  • Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 3 2 3 5
  • Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 3 2 3
  • Small Conductance Calcium-Activated Potassium Channel 3 2 3
  • SKCa 3 3 4
  • KCa2.3 3 4
  • SKCA3 3 4
  • SK3 3 4
  • HSK3 3
  • K3 4

External Ids for KCNN3 Gene

Previous GeneCards Identifiers for KCNN3 Gene

  • GC01M152495
  • GC01M150410
  • GC01M151455
  • GC01M151896
  • GC01M151492
  • GC01M152946
  • GC01M154680
  • GC01M126042

Summaries for KCNN3 Gene

Entrez Gene Summary for KCNN3 Gene

  • Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for KCNN3 Gene

KCNN3 (Potassium Calcium-Activated Channel Subfamily N Member 3) is a Protein Coding gene. Diseases associated with KCNN3 include spinocerebellar ataxia 2 and bipolar disorder. Among its related pathways are Transmission across Chemical Synapses and Insulin secretion. GO annotations related to this gene include protein heterodimerization activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNN1.

UniProtKB/Swiss-Prot for KCNN3 Gene

  • Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.

Tocris Summary for KCNN3 Gene

  • Calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).

Gene Wiki entry for KCNN3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNN3 Gene

Genomics for KCNN3 Gene

Regulatory Elements for KCNN3 Gene

Promoters for KCNN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KCNN3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the KCNN3 gene promoter:

Genomic Location for KCNN3 Gene

Chromosome:
1
Start:
154,697,455 bp from pter
End:
154,870,280 bp from pter
Size:
172,826 bases
Orientation:
Minus strand

Genomic View for KCNN3 Gene

Genes around KCNN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNN3 Gene

Proteins for KCNN3 Gene

  • Protein details for KCNN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGI6-KCNN3_HUMAN
    Recommended name:
    Small conductance calcium-activated potassium channel protein 3
    Protein Accession:
    Q9UGI6
    Secondary Accessions:
    • B1ANX0
    • O43517
    • Q86VF9
    • Q8WXG7

    Protein attributes for KCNN3 Gene

    Size:
    736 amino acids
    Molecular mass:
    82026 Da
    Quaternary structure:
    • Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).

    Alternative splice isoforms for KCNN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNN3 Gene

Proteomics data for KCNN3 Gene at MOPED

Post-translational modifications for KCNN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNN3 Gene

Antibody Products

No data available for DME Specific Peptides for KCNN3 Gene

Domains & Families for KCNN3 Gene

Gene Families for KCNN3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UGI6

UniProtKB/Swiss-Prot:

KCNN3_HUMAN :
  • Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily.
Family:
  • Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily.
genes like me logo Genes that share domains with KCNN3: view

Function for KCNN3 Gene

Molecular function for KCNN3 Gene

GENATLAS Biochemistry:
potassium intermediate/small conductance calcium-activated channel,subfamily N,member 3
UniProtKB/Swiss-Prot Function:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
genes like me logo Genes that share phenotypes with KCNN3: view

Animal Models for KCNN3 Gene

MGI Knock Outs for KCNN3:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNN3

CRISPR Products

miRNA for KCNN3 Gene

miRTarBase miRNAs that target KCNN3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNN3 Gene

Localization for KCNN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNN3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNN3 Gene COMPARTMENTS Subcellular localization image for KCNN3 gene
Compartment Confidence
plasma membrane 5
nucleus 4
endoplasmic reticulum 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for KCNN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
genes like me logo Genes that share ontologies with KCNN3: view

Pathways & Interactions for KCNN3 Gene

genes like me logo Genes that share pathways with KCNN3: view

Pathways by source for KCNN3 Gene

1 KEGG pathway for KCNN3 Gene

Interacting Proteins for KCNN3 Gene

Gene Ontology (GO) - Biological Process for KCNN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport IEA --
genes like me logo Genes that share ontologies with KCNN3: view

No data available for SIGNOR curated interactions for KCNN3 Gene

Drugs & Compounds for KCNN3 Gene

(20) Drugs for KCNN3 Gene - From: IUPHAR, DGIdb, Novoseek, Tocris, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Miconazole Approved, Investigational Pharma Antagonist, Pore Blocker, Target, inhibitor 3026
Procaine Approved, Investigational Pharma Channel blocker, Target, binder 35
Tubocurarine Approved Pharma antagonist 0
CyPPA Pharma Agonist, Activator Activator of KCa2.2 and KCa2.3 channels 0
apamin Pharma Antagonist, Pore Blocker 0

(9) Additional Compounds for KCNN3 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+)-tubocurarine
Antagonist, Pore Blocker
1-EBIO
10045-45-1
BMS 191011
202821-81-6
DCEBIO
60563-36-2
SKA 31
40172-65-4

(5) Tocris Compounds for KCNN3 Gene

Compound Action Cas Number
1-EBIO Activator of epithelial KCa channels 10045-45-1
BMS 191011 Potent BKCa (KCa1.1) channel opener 202821-81-6
CyPPA Activator of KCa2.2 and KCa2.3 channels 73029-73-9
DCEBIO Activates Cl- conductance and hKCa3.1 channels 60563-36-2
SKA 31 Activator of KCa3.1 and KCa2 channels 40172-65-4
genes like me logo Genes that share compounds with KCNN3: view

Transcripts for KCNN3 Gene

Unigene Clusters for KCNN3 Gene

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNN3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b
SP1:
SP2: - -
SP3: -
SP4: - -

Relevant External Links for KCNN3 Gene

GeneLoc Exon Structure for
KCNN3
ECgene alternative splicing isoforms for
KCNN3

Expression for KCNN3 Gene

mRNA expression in normal human tissues for KCNN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KCNN3 Gene

This gene is overexpressed in Heart (32.9), Plasma (23.8), and Frontal cortex (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNN3 Gene



SOURCE GeneReport for Unigene cluster for KCNN3 Gene Hs.490765

genes like me logo Genes that share expression patterns with KCNN3: view

Protein tissue co-expression partners for KCNN3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KCNN3 Gene

Orthologs for KCNN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNN3 35
  • 93.53 (n)
  • 95.84 (a)
KCNN3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNN3 35
  • 90.4 (n)
  • 94.63 (a)
KCNN3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnn3 35
  • 89.88 (n)
  • 93.43 (a)
Kcnn3 16
Kcnn3 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNN3 35
  • 98.9 (n)
  • 98.7 (a)
KCNN3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnn3 35
  • 90.06 (n)
  • 93.84 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNN3 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNN3 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNN3 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNN3 36
  • 93 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii kcnn3 35
  • 70.7 (n)
  • 76.59 (a)
kcnn3 36
  • 63 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.113 35
fruit fly
(Drosophila melanogaster)
Insecta SK 37
  • 54 (a)
SK 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C03F11.1 37
  • 37 (a)
C53A5.5 37
  • 30 (a)
kcnl-1 36
  • 26 (a)
ManyToMany
kcnl-2 36
  • 31 (a)
ManyToMany
kcnl-3 36
  • 26 (a)
ManyToMany
kcnl-4 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
OneToMany
Species with no ortholog for KCNN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KCNN3 Gene

ENSEMBL:
Gene Tree for KCNN3 (if available)
TreeFam:
Gene Tree for KCNN3 (if available)

Paralogs for KCNN3 Gene

Paralogs for KCNN3 Gene

(5) SIMAP similar genes for KCNN3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCNN3: view

Variants for KCNN3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for KCNN3 Gene

Q9UGI6-KCNN3_HUMAN
The second poly-Gln region of KCNN3 is highly polymorphic and the number of Gln varies from 12 to 28 in the population.

Sequence variations from dbSNP and Humsavar for KCNN3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs883319 -- 154,785,946(+) AATAG(C/T)CCCAT intron-variant
rs883320 -- 154,786,324(-) TTTCT(A/G)TCTTG intron-variant
rs883905 -- 154,842,890(-) AGTGG(C/T)AAAGT intron-variant
rs884664 -- 154,731,249(+) TCCTC(A/G)TGACA intron-variant
rs906274 -- 154,806,646(-) TCATG(A/C)TCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNN3 Gene

Variant ID Type Subtype PubMed ID
nsv521887 CNV Gain 19592680
nsv470740 CNV Gain 18288195
nsv464050 CNV Gain 19166990
nsv509491 CNV Insertion 20534489
esv2574257 CNV Insertion 19546169
esv1554680 CNV Insertion 17803354
esv2718350 CNV Deletion 23290073
esv2673228 CNV Deletion 23128226
nsv872452 CNV Gain 21882294
esv275470 CNV Gain+Loss 21479260
esv2718363 CNV Deletion 23290073
esv29982 CNV Gain 17803354
nsv2966 CNV Insertion 18451855
nsv464073 CNV Loss 19166990

Variation tolerance for KCNN3 Gene

Residual Variation Intolerance Score: 8.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.28; 62.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNN3 Gene

HapMap Linkage Disequilibrium report
KCNN3
Human Gene Mutation Database (HGMD)
KCNN3

Disorders for KCNN3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for KCNN3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia 2
  • amyotrophic lateral sclerosis 13
bipolar disorder
  • major affective disorder 1
schizophrenia
  • schizophrenia 12
hirschsprung disease 1
  • hirschsprung's disease
- elite association - COSMIC cancer census association via MalaCards
Search KCNN3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KCNN3

Genetic Association Database (GAD)
KCNN3
Human Genome Epidemiology (HuGE) Navigator
KCNN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNN3
genes like me logo Genes that share disorders with KCNN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNN3 Gene

Publications for KCNN3 Gene

  1. Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder? (PMID: 9491810) Chandy K.G. … Gargus J.J. (Mol. Psychiatry 1998) 2 3 4 67
  2. KCa2.3 channel-dependent hyperpolarization increases melanoma cell motility. (PMID: 19646982) Chantome A. … Joulin V. (Exp. Cell Res. 2009) 3 23
  3. Analysis of Single Nucleotide Polymorphisms (SNPs) of the small-conductance calcium activated potassium channel (SK3) gene as genetic modifier of the cardiac phenotype in myotonic dystrophy type 1 patients. (PMID: 19472917) Rinaldi F. … Novelli G. (Acta Myol 2008) 3 23
  4. Schizophrenia and polymorphic CAG repeats array of calcium-activated potassium channel (KCNN3) gene in Serbian population. (PMID: 16393881) IvkoviA8 M. … Romac S. (Int. J. Neurosci. 2006) 3 23
  5. SK3 trafficking in hippocampal cells: the role of different molecular domains. (PMID: 17061167) Decimo I. … Fumagalli G. (Biosci. Rep. 2006) 3 23

Products for KCNN3 Gene

Sources for KCNN3 Gene

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