Aliases for KCNN3 Gene
Aliases for KCNN3 Gene
- Potassium Calcium-Activated Channel Subfamily N Member 3 2 3 5
- Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 3 2 3
- Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 3 2 3
- Small Conductance Calcium-Activated Potassium Channel 3 2 3
- SKCa 3 3 4
- KCa2.3 3 4
External Ids for KCNN3 Gene
- HGNC: 6292
- Entrez Gene: 3782
- Ensembl: ENSG00000143603
- OMIM: 602983
- UniProtKB: Q9UGI6
Previous GeneCards Identifiers for KCNN3 Gene
- GC01M152495
- GC01M150410
- GC01M151455
- GC01M151896
- GC01M151492
- GC01M152946
- GC01M154680
- GC01M126042
Summaries for KCNN3 Gene
-
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for KCNN3 Gene
KCNN3 (Potassium Calcium-Activated Channel Subfamily N Member 3) is a Protein Coding gene. Diseases associated with KCNN3 include Spinocerebellar Ataxia 2 and Bipolar Disorder. Among its related pathways are Insulin secretion and Transmission across Chemical Synapses. GO annotations related to this gene include protein heterodimerization activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNN2.
UniProtKB/Swiss-Prot for KCNN3 Gene
-
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
-
Calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNN3 Gene
Genomics for KCNN3 Gene
Regulatory Elements for KCNN3 Gene
Enhancers for KCNN3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around KCNN3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the KCNN3 gene promoter:
Regulatory Element Products
Genomic Location for KCNN3 Gene
- Chromosome:
- 1
- Start:
- 154,697,455 bp from pter
- End:
- 154,870,280 bp from pter
- Size:
- 172,826 bases
- Orientation:
- Minus strand
Genomic View for KCNN3 Gene
Genes around KCNN3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by Ensembl
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC
KCNN3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KCNN3 Gene
Proteins for KCNN3 Gene
-
Protein details for KCNN3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UGI6-KCNN3_HUMAN
- Recommended name:
- Small conductance calcium-activated potassium channel protein 3
- Protein Accession:
- Q9UGI6
- B1ANX0
- O43517
- Q86VF9
- Q8WXG7
Protein attributes for KCNN3 Gene
- Size:
- 736 amino acids
- Molecular mass:
- 82026 Da
- Quaternary structure:
-
- Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).
Protein Expression for KCNN3 Gene
Post-translational modifications for KCNN3 Gene
Other Protein References for KCNN3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for KCNN3
- Novus Biologicals Antibodies for KCNN3
-
Abcam antibodies for KCNN3
- Invitrogen Antibodies for KCNN3
- antibodies-online Antibodies for KCNN3: See all 23
- GeneTex KCNN3 antibody for KCNN3
Protein Products
-
OriGene Purified Proteins for KCNN3
- Search Origene for MassSpec and Protein Over-expression Lysates for KCNN3
- Origene Custom Protein Services for KCNN3
- antibodies-online Proteins for KCNN3: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for KCNN3
-
Abcam proteins for KCNN3
Assay Products
No data available for DME Specific Peptides for KCNN3 Gene
Domains & Families for KCNN3 Gene
Gene Families for KCNN3 Gene
- HGNC:
- IUPHAR :
Protein Domains for KCNN3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for KCNN3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UGI6UniProtKB/Swiss-Prot:
KCNN3_HUMAN :- Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily.
- Family:
-
- Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily.
Function for KCNN3 Gene
Molecular function for KCNN3 Gene
- GENATLAS Biochemistry:
- potassium intermediate/small conductance calcium-activated channel,subfamily N,member 3
- UniProtKB/Swiss-Prot Function:
- Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005516 | calmodulin binding | IBA | -- |
| GO:0015269 | calcium-activated potassium channel activity | IEA | -- |
| GO:0016286 | small conductance calcium-activated potassium channel activity | IBA,IEA | -- |
Phenotypes for KCNN3 Gene
- MGI mutant phenotypes for KCNN3:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for KCNN3:
Animal Models for KCNN3 Gene
- MGI Knock Outs for KCNN3:
-
- Kcnn3 tm2.2Jpad
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for KCNN3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KCNN3 gene
- Search ViGene Biosciences for KCNN3
CRISPR Products
-
OriGene CRISPR knockouts for KCNN3
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNN3
- GenScript: Design CRISPR guide RNA sequences for KCNN3
miRNA for KCNN3 Gene
- miRTarBase miRNAs that target KCNN3
-
- hsa-mir-889-3p (MIRT396996)
- hsa-mir-155-5p (MIRT440402)
- hsa-mir-3152-3p (MIRT442419)
- hsa-mir-6867-5p (MIRT442420)
- hsa-mir-3182 (MIRT442421)
- hsa-mir-1237-3p (MIRT442422)
- hsa-mir-92a-2-5p (MIRT443688)
- hsa-mir-2053 (MIRT443689)
- hsa-mir-6857-5p (MIRT443690)
- hsa-mir-4450 (MIRT443691)
- hsa-mir-8089 (MIRT443692)
- hsa-mir-4700-5p (MIRT443693)
- hsa-mir-4667-5p (MIRT443694)
- hsa-mir-6768-3p (MIRT443695)
- hsa-mir-4753-5p (MIRT443696)
- hsa-mir-1277-5p (MIRT522889)
- hsa-mir-3942-3p (MIRT522890)
- hsa-mir-5100 (MIRT522891)
- hsa-mir-190a-3p (MIRT522892)
- hsa-mir-892c-5p (MIRT522893)
- hsa-mir-5011-5p (MIRT522894)
- hsa-mir-5003-3p (MIRT522895)
- hsa-mir-335-3p (MIRT612829)
- hsa-mir-30e-3p (MIRT612830)
- hsa-mir-30d-3p (MIRT612831)
- hsa-mir-30a-3p (MIRT612832)
- hsa-mir-511-5p (MIRT612833)
- hsa-mir-6830-3p (MIRT612834)
- hsa-mir-29a-5p (MIRT612835)
- hsa-mir-3920 (MIRT612836)
- hsa-mir-622 (MIRT612837)
- hsa-mir-4444 (MIRT614940)
- hsa-mir-4711-3p (MIRT614941)
- hsa-mir-4724-3p (MIRT642049)
- hsa-mir-501-5p (MIRT642050)
- hsa-mir-6782-3p (MIRT642051)
- hsa-mir-500b-5p (MIRT642052)
- hsa-mir-362-5p (MIRT642053)
- hsa-mir-2681-5p (MIRT656990)
- hsa-mir-421 (MIRT656991)
- hsa-mir-1245b-3p (MIRT656992)
- hsa-mir-3620-3p (MIRT656993)
- hsa-mir-6865-3p (MIRT656994)
- hsa-mir-4709-5p (MIRT656995)
- hsa-mir-3613-3p (MIRT656996)
- hsa-mir-548p (MIRT656997)
- hsa-mir-181c-3p (MIRT656998)
- hsa-mir-5683 (MIRT656999)
- hsa-mir-548c-3p (MIRT657000)
- hsa-mir-203b-3p (MIRT673994)
- hsa-mir-7158-3p (MIRT673995)
- hsa-mir-378a-5p (MIRT673996)
- hsa-mir-7111-3p (MIRT673997)
- hsa-mir-6131 (MIRT673998)
- hsa-mir-6821-3p (MIRT673999)
- hsa-mir-6790-3p (MIRT674000)
- hsa-mir-4680-5p (MIRT674001)
- hsa-mir-4635 (MIRT674002)
- hsa-mir-3663-5p (MIRT674003)
- hsa-mir-3653-5p (MIRT674004)
- hsa-mir-6769b-3p (MIRT674005)
- hsa-mir-4723-3p (MIRT674006)
- hsa-mir-3183 (MIRT674007)
- hsa-mir-3934-5p (MIRT674008)
- hsa-mir-764 (MIRT674009)
- hsa-mir-125a-3p (MIRT674010)
miRNA Products
- Search ViGene Biosciences for KCNN3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for KCNN3
- Browse OriGene Inhibitory RNA Products For KCNN3
-
ViGene Biosciences ready-to-package AAV shRNAs for KCNN3 gene
Cell Line Products
-
Horizon Cell Lines for KCNN3
-
ViGene Biosciences adenoviral particle packaged cDNA for KCNN3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for KCNN3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KCNN3 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNN3 Gene
Localization for KCNN3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KCNN3 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 4 |
| endoplasmic reticulum | 2 |
| cytoskeleton | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005886 | plasma membrane | IEA,TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0043025 | neuronal cell body | IBA | -- |
Pathways & Interactions for KCNN3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Insulin secretion | ||
| 2 | Transmission across Chemical Synapses |
.62
|
|
| 3 | Potassium Channels | ||
Pathways by source for KCNN3 Gene
3 Reactome pathways for KCNN3 Gene
1 KEGG pathway for KCNN3 Gene
Interacting Proteins for KCNN3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006813 | potassium ion transport | IEA | -- |
| GO:0071805 | potassium ion transmembrane transport | IEA | -- |
| GO:1903955 | positive regulation of protein targeting to mitochondrion | IMP | 24270810 |
No data available for SIGNOR curated interactions for KCNN3 Gene
Drugs & Compounds for KCNN3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Miconazole | Approved, Investigational, Vet_approved | Pharma | Antagonist, Pore Blocker, Target, inhibitor | 3706 | ||
| Procaine | Approved, Investigational, Vet_approved | Pharma | Channel blocker, Target, binder | 49 | ||
| Dequalinium | Approved | Pharma | 2 | |||
| Tubocurarine | Approved | Pharma | antagonist | 0 | ||
| Apamin | Pharma | Antagonist, Pore Blocker | KCa2 channel blocker (small conductance) | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (+)-tubocurarine |
|
Antagonist, Pore Blocker |
|
|||
| TRAM 34 |
|
289905-88-0 |
|
|
(5) Tocris Compounds for KCNN3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Apamin | KCa2 channel blocker (small conductance) | 24345-16-2 |
| CyPPA | Activator of KCa2.2 and KCa2.3 channels | 73029-73-9 |
| Iberiotoxin | KCa channel blocker (big conductance) | 129203-60-7 |
| Paxilline | SERCA ATPase blocker. Also potent BKCa channel blocker | 57186-25-1 |
| TRAM 34 | Potent and highly selective KCa3.1 channel blocker | 289905-88-0 |
Transcripts for KCNN3 Gene
mRNA/cDNA for KCNN3 Gene
- (3) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (69) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KCNN3 Gene
- Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for KCNN3
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNN3
- GenScript: Design CRISPR guide RNA sequences for KCNN3
miRNA Products
- Search ViGene Biosciences for KCNN3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for KCNN3
- Browse OriGene Inhibitory RNA Products For KCNN3
-
ViGene Biosciences ready-to-package AAV shRNAs for KCNN3 gene
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||
| SP4: | - | - |
Expression for KCNN3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Epithelial Cells
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Neural Tube (Nervous System)
This gene is overexpressed in Heart (32.9), Plasma (23.8), and Frontal cortex (10.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNN3 Gene
NURSA nuclear receptor signaling pathways regulating expression of KCNN3 Gene:
KCNN3SOURCE GeneReport for Unigene cluster for KCNN3 Gene:
Hs.490765Evidence on tissue expression from TISSUES for KCNN3 Gene
- Nervous system(2.9)
- Muscle(2.2)
Primer Products
-
OriGene qPCR primer pairs for KCNN3
-
OriGene qPCR primer pairs and template standards for KCNN3
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNN3 Gene
Orthologs for KCNN3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KCNN3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | KCNN3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | KCNN3 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Kcnn3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Kcnn3 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | KCNN3 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | KCNN3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | KCNN3 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | KCNN3 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | kcnn3 34 35 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.113 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | SK 36 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | C03F11.1 36 |
|
|
|
| kcnl-2 35 |
|
ManyToMany | |||
| C53A5.5 36 |
|
|
|||
| kcnl-4 35 |
|
ManyToMany | |||
| kcnl-1 35 |
|
ManyToMany | |||
| kcnl-3 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for KCNN3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for KCNN3 Gene
(5) SIMAP similar genes for KCNN3 Gene using alignment to 3 proteins:
Variants for KCNN3 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for KCNN3 Gene
- KCNN3_HUMAN-Q9UGI6
- The second poly-Gln region of KCNN3 is highly polymorphic and the number of Gln varies from 12 to 28 in the population.
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs193920929 | Uncertain significance | 154,771,974(-) | GAAAG(G/T)TATTC | splice-donor-variant | |
| rs1000000159 | -- | 154,725,462(+) | CATTT(A/T)GTGTC | intron-variant | |
| rs1000049926 | -- | 154,845,512(+) | CACTG(C/G/T)GGGGG | intron-variant | |
| rs1000050290 | -- | 154,848,255(+) | CAGTC(A/G)CTTCG | intron-variant | |
| rs1000069199 | -- | 154,791,852(+) | AACCT(C/T)CTCTG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1554680 | CNV | insertion | 17803354 |
| esv2574257 | CNV | insertion | 19546169 |
| esv2673228 | CNV | deletion | 23128226 |
| esv2718350 | CNV | deletion | 23290073 |
| esv2718363 | CNV | deletion | 23290073 |
| esv275470 | CNV | gain+loss | 21479260 |
| esv29982 | CNV | gain | 17803354 |
| esv3354801 | CNV | duplication | 20981092 |
| esv3362664 | CNV | duplication | 20981092 |
| esv3435288 | CNV | duplication | 20981092 |
| esv3540978 | CNV | deletion | 23714750 |
| esv3574452 | CNV | gain | 25503493 |
| nsv2966 | CNV | insertion | 18451855 |
| nsv464050 | CNV | gain | 19166990 |
| nsv464073 | CNV | loss | 19166990 |
| nsv470740 | CNV | gain | 18288195 |
| nsv472399 | CNV | novel sequence insertion | 20440878 |
| nsv509491 | CNV | insertion | 20534489 |
| nsv521887 | CNV | gain | 19592680 |
| nsv547958 | CNV | gain | 21841781 |
| nsv547960 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
8.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.28;
62.67% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for KCNN3 Gene
Disorders for KCNN3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spinocerebellar ataxia 2 |
|
|
| bipolar disorder |
|
|
| retinitis pigmentosa 19 |
|
|
| myotonic dystrophy |
|
|
| retinitis pigmentosa 14 |
|
|
Search KCNN3 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for KCNN3
No data available for UniProtKB/Swiss-Prot and Genatlas for KCNN3 Gene
Publications for KCNN3 Gene
- Analysis of Single Nucleotide Polymorphisms (SNPs) of the small-conductance calcium activated potassium channel (SK3) gene as genetic modifier of the cardiac phenotype in myotonic dystrophy type 1 patients. (PMID: 19472917) Rinaldi F. … Novelli G. (Acta Myol 2008) 3 22 46 64
- Schizophrenia and polymorphic CAG repeats array of calcium-activated potassium channel (KCNN3) gene in Serbian population. (PMID: 16393881) IvkoviA8 M. … Romac S. (Int. J. Neurosci. 2006) 3 22 46 64
- [Transmission disequilibrium analysis of 1137-1140 Del GTGA frameshift mutation within the KCNN3 gene and schizophrenia based on family trios]. (PMID: 16086287) Hong X.H. … Wu C.R. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005) 3 22 46 64
- Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility. (PMID: 16162291) Curtain R. … Griffiths L. (BMC Med. Genet. 2005) 3 22 46 64
- CAG repeat polymorphism within the KCNN3 gene is a significant contributor to susceptibility to anorexia nervosa: a case-control study of female patients and several ethnic groups in the Israeli Jewish population. (PMID: 15389773) Koronyo-Hamaoui M. … Weizman A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004) 3 22 46 64
Products for KCNN3 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for KCNN3
- Search Origene for MassSpec and Protein Over-expression Lysates for KCNN3
- Origene Custom Protein Services for KCNN3
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for KCNN3
- Browse OriGene Inhibitory RNA Products For KCNN3
- OriGene qPCR primer pairs and template standards for KCNN3
- OriGene qPCR primer pairs for KCNN3
- OriGene CRISPR knockouts for KCNN3
- OriGene ORF clones in human for KCNN3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For KCNN3
- GenScript: Next-day shipping cDNA ORF clone for KCNN3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for KCNN3
- GenScript Custom Assay Services for KCNN3
- GenScript Custom overexpressing Cell Line Services for KCNN3
- GenScript: Design CRISPR guide RNA sequences for KCNN3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for KCNN3
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for KCNN3
- Novus Biologicals proteins and lysates for KCNN3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for KCNN3
- Abcam proteins for KCNN3
- Search for Assays for KCNN3 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- antibodies-online Antibodies for KCNN3: See all 23
- Search antibodies-online for kits
- antibodies-online Proteins for KCNN3: See all 4
- Search antibodies-online for peptides
- GeneTex KCNN3 antibody for KCNN3
- Search GeneTex for Proteins for KCNN3
- ViGene Biosciences adenoviral particle packaged cDNA for KCNN3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for KCNN3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for KCNN3 gene
- Search ViGene Biosciences for KCNN3
- Horizon Cell Lines for KCNN3
- Cyagen custom Knockout/knockin (KOKI) mouse models for KCNN3
- VectorBuilder custom plasmid, inducible vectors for KCNN3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KCNN3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for KCNN3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer