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Aliases for KCNN2 Gene

Aliases for KCNN2 Gene

  • Potassium Calcium-Activated Channel Subfamily N Member 2 2 3
  • Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 2 2 3 5
  • Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 2 2 3
  • Small Conductance Calcium-Activated Potassium Channel 2 2 3
  • SKCa 2 3 4
  • KCa2.2 3 4
  • SKCA2 3 4
  • SK2 3 4
  • Apamin-Sensitive Small-Conductance Ca2+-Activated Potassium Channel 3
  • HSK2 3

External Ids for KCNN2 Gene

Previous GeneCards Identifiers for KCNN2 Gene

  • GC05P113302
  • GC05P113728
  • GC05P113774
  • GC05P113725
  • GC05P108880
  • GC05P114360

Summaries for KCNN2 Gene

Entrez Gene Summary for KCNN2 Gene

  • Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for KCNN2 Gene

KCNN2 (Potassium Calcium-Activated Channel Subfamily N Member 2) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Bile secretion. GO annotations related to this gene include protein homodimerization activity and ion channel activity. An important paralog of this gene is KCNN1.

UniProtKB/Swiss-Prot for KCNN2 Gene

  • Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.

Tocris Summary for KCNN2 Gene

  • Calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).

Gene Wiki entry for KCNN2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNN2 Gene

Genomics for KCNN2 Gene

Regulatory Elements for KCNN2 Gene

Genomic Location for KCNN2 Gene

Chromosome:
5
Start:
114,056,006 bp from pter
End:
114,496,500 bp from pter
Size:
440,495 bases
Orientation:
Plus strand

Genomic View for KCNN2 Gene

Genes around KCNN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNN2 Gene

Proteins for KCNN2 Gene

  • Protein details for KCNN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2S1-KCNN2_HUMAN
    Recommended name:
    Small conductance calcium-activated potassium channel protein 2
    Protein Accession:
    Q9H2S1
    Secondary Accessions:
    • A6NF94
    • Q0VFZ4
    • Q6PJI0
    • Q6X2Y2

    Protein attributes for KCNN2 Gene

    Size:
    579 amino acids
    Molecular mass:
    63760 Da
    Quaternary structure:
    • Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).

    Alternative splice isoforms for KCNN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNN2 Gene

Proteomics data for KCNN2 Gene at MOPED

Post-translational modifications for KCNN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNN2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for KCNN2

No data available for DME Specific Peptides for KCNN2 Gene

Domains & Families for KCNN2 Gene

Gene Families for KCNN2 Gene

Suggested Antigen Peptide Sequences for KCNN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2S1

UniProtKB/Swiss-Prot:

KCNN2_HUMAN :
  • Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.
Family:
  • Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.
genes like me logo Genes that share domains with KCNN2: view

Function for KCNN2 Gene

Molecular function for KCNN2 Gene

UniProtKB/Swiss-Prot Function:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.

Gene Ontology (GO) - Molecular Function for KCNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IPI 17110593
genes like me logo Genes that share ontologies with KCNN2: view
genes like me logo Genes that share phenotypes with KCNN2: view

Animal Model Products

miRNA for KCNN2 Gene

miRTarBase miRNAs that target KCNN2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNN2 Gene

Localization for KCNN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNN2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNN2 Gene COMPARTMENTS Subcellular localization image for KCNN2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 3
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KCNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0043025 neuronal cell body IBA --
genes like me logo Genes that share ontologies with KCNN2: view

Pathways & Interactions for KCNN2 Gene

genes like me logo Genes that share pathways with KCNN2: view

Pathways by source for KCNN2 Gene

1 BioSystems pathway for KCNN2 Gene
3 KEGG pathways for KCNN2 Gene

Interacting Proteins for KCNN2 Gene

SIGNOR curated interactions for KCNN2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for KCNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNN2: view

Drugs & Compounds for KCNN2 Gene

(17) Drugs for KCNN2 Gene - From: IUPHAR, DGIdb, Novoseek, Tocris, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Miconazole Approved, Investigational Pharma Antagonist, Pore Blocker, Target, inhibitor 3026
Procaine Approved, Investigational Pharma Channel blocker, Target, binder 35
Tubocurarine Approved Pharma antagonist 0
CyPPA Pharma Agonist, Activator Activator of KCa2.2 and KCa2.3 channels 0
apamin Pharma Antagonist, Pore Blocker 0

(8) Additional Compounds for KCNN2 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+)-tubocurarine
Antagonist, Pore Blocker
1-EBIO
10045-45-1
BMS 191011
202821-81-6
DCEBIO
60563-36-2
SKA 31
40172-65-4
genes like me logo Genes that share compounds with KCNN2: view

Transcripts for KCNN2 Gene

Unigene Clusters for KCNN2 Gene

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2: -
SP3:

Relevant External Links for KCNN2 Gene

GeneLoc Exon Structure for
KCNN2
ECgene alternative splicing isoforms for
KCNN2

Expression for KCNN2 Gene

mRNA expression in normal human tissues for KCNN2 Gene

mRNA differential expression in normal tissues according to GTEx for KCNN2 Gene

This gene is overexpressed in Adrenal Gland (x10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCNN2 Gene



SOURCE GeneReport for Unigene cluster for KCNN2 Gene Hs.98280

mRNA Expression by UniProt/SwissProt for KCNN2 Gene

Q9H2S1-KCNN2_HUMAN
Tissue specificity: Expressed in atrial myocytes (at protein level). Widely expressed.
genes like me logo Genes that share expression patterns with KCNN2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for KCNN2 Gene

Orthologs for KCNN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNN2 36
  • 100 (a)
OneToOne
KCNN2 35
  • 99.71 (n)
  • 99.65 (a)
cow
(Bos Taurus)
Mammalia KCNN2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNN2 36
  • 67 (a)
OneToOne
LOC474640 35
  • 94.72 (n)
  • 97.48 (a)
mouse
(Mus musculus)
Mammalia Kcnn2 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNN2 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100910229 35
  • 92.22 (n)
  • 97.47 (a)
chicken
(Gallus gallus)
Aves SK2 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNN2 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1499 35
zebrafish
(Danio rerio)
Actinopterygii KCNN2 36
  • 86 (a)
OneToOne
si:dkey-76p7.5 35
  • 76.12 (n)
  • 87.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta SK 37
  • 65 (a)
SK 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C03F11.1 37
  • 39 (a)
C53A5.5 37
  • 29 (a)
kcnl-1 36
  • 24 (a)
ManyToMany
kcnl-2 36
  • 30 (a)
ManyToMany
kcnl-3 36
  • 24 (a)
ManyToMany
kcnl-4 36
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToMany
Species with no ortholog for KCNN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KCNN2 Gene

ENSEMBL:
Gene Tree for KCNN2 (if available)
TreeFam:
Gene Tree for KCNN2 (if available)

Paralogs for KCNN2 Gene

Paralogs for KCNN2 Gene

(4) SIMAP similar genes for KCNN2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCNN2: view

Variants for KCNN2 Gene

Sequence variations from dbSNP and Humsavar for KCNN2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs40177 -- 114,341,174(-) GTCAG(C/T)CTTTT intron-variant
rs173991 -- 114,346,045(-) caaca(C/T)tttgg intron-variant
rs41235 -- 114,357,665(-) catat(A/C)cacca intron-variant
rs41236 -- 114,320,064(+) TGGAA(A/G)TTTTA intron-variant
rs168110 -- 114,353,409(-) AATTT(A/G)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNN2 Gene

Variant ID Type Subtype PubMed ID
nsv882728 CNV Loss 21882294
nsv830451 CNV Gain+Loss 17160897
nsv882729 CNV Gain 21882294
esv8535 CNV Gain 19470904
nsv830452 CNV Loss 17160897

Variation tolerance for KCNN2 Gene

Residual Variation Intolerance Score: 5.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNN2 Gene

HapMap Linkage Disequilibrium report
KCNN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNN2 Gene

Disorders for KCNN2 Gene

Relevant External Links for KCNN2

Genetic Association Database (GAD)
KCNN2
Human Genome Epidemiology (HuGE) Navigator
KCNN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNN2

No disorders were found for KCNN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNN2 Gene

Publications for KCNN2 Gene

  1. Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization. (PMID: 10991935) Desai R. … Attali B. (J. Biol. Chem. 2000) 3 4 23 67
  2. Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel). (PMID: 19815520) Lu L. … Chiamvimonvat N. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  3. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (PMID: 16382103) Wei A.D. … Wulff H. (Pharmacol. Rev. 2005) 2 3
  4. Calcium-dependent regulation of secretion in biliary epithelial cells: the role of apamin-sensitive SK channels. (PMID: 15362045) Feranchak A.P. … Fitz J.G. (Gastroenterology 2004) 3 23
  5. Distribution of Ca2+-activated K channels, SK2 and SK3, in the normal and Hirschsprung's disease bowel. (PMID: 12778407) Piotrowska A.P. … Puri P. (J. Pediatr. Surg. 2003) 3 23

Products for KCNN2 Gene

Sources for KCNN2 Gene

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