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KCNN2 Gene

protein-coding   GIFtS: 65
GCID: GC05P113725

Potassium Intermediate/Small Conductance Calcium-Activated...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Intermediate/Small Conductance Calcium-Activated Channel,
Subfamily N, Member 21 2
     Apamin-Sensitive Small-Conductance Ca2+-Activated Potassium Channel2
SK22 3 5     hSK22
KCa2.22 3     Small Conductance Calcium-Activated Potassium Channel Protein 22
SKCa 22 3     SKCa23
SKCA22     

External Ids:    HGNC: 62911   Entrez Gene: 37812   Ensembl: ENSG000000807097   OMIM: 6058795   UniProtKB: Q9H2S13   

Export aliases for KCNN2 gene to outside databases

Previous GC identifers: GC05P113302 GC05P114100 GC05P113728 GC05P113774 GC05P108880


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNN2 Gene:
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for
several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the
AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein
encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal
excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of
potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent
calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results
in multiple transcript variants. (provided by RefSeq, May 2013)

GeneCards Summary for KCNN2 Gene:
KCNN2 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2) is a protein-coding gene. Diseases associated with KCNN2 include hirschsprung's disease, and neuronitis. GO annotations related to this gene include protein homodimerization activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNN4.

UniProtKB/Swiss-Prot: KCNN2_HUMAN, Q9H2S1
Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed
by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of
synaptic afterhyperpolarization. The channel is blocked by apamin

summary for KCNN2 Gene:
Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+
ions across biological membranes. They are broadly classified into three subtypes, SK, IK and BK channels,
based on their conductance (small, intermediate and big conductance respectively). The small conductance KCa
channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance
KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both
play important roles in many processes involving Ca2+-dependent signalling in both electrically excitable
and non-excitable cells. The BK family of KCa channels (also known as Slo or Maxi-K channels) are also
voltage-sensitive and include KCa1.1 (Slo1), KCa4.1 (Slo2.2), KCa4.2 (Slo2.1) and KCa5.1 (Slo3). These
channels do not require calmodulin for activation as they contain three direct bivalent cation binding
sites.

Gene Wiki entry for KCNN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNN2 gene promoter:
         Elk-1   AML1a   CUTL1   LCR-F1   E4BP4   Evi-1   PPAR-gamma1   Nkx6-1   PPAR-gamma2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNN2 promoter sequence
   Search Chromatin IP Primers for KCNN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q22.3   Ensembl cytogenetic band:  5q22.3   HGNC cytogenetic band: 5q22.3

KCNN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNN2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P113725:  view genomic region     (about GC identifiers)

Start:
113,696,642 bp from pter      End:
113,832,337 bp from pter
Size:
135,696 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KCNN2_HUMAN, Q9H2S1 (See protein sequence)
Recommended Name: Small conductance calcium-activated potassium channel protein 2  
Size: 579 amino acids; 63760 Da
Subunit: Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit
which regulates the channel activity through calcium-binding (By similarity)
Secondary accessions: A6NF94 Q0VFZ4 Q6PJI0 Q6X2Y2
Alternative splicing: 2 isoforms:  Q9H2S1-1   Q9H2S1-2   

Explore the universe of human proteins at neXtProt for KCNN2: NX_Q9H2S1

Explore proteomics data for KCNN2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys401
  • Modification sites at PhosphoSitePlus

  • See KCNN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001265133.1  NP_067627.2  NP_740721.1  

    ENSEMBL proteins: 
     ENSP00000427120   ENSP00000421439   ENSP00000421095   ENSP00000264773  
    Reactome Protein details: Q9H2S1

    KCNN2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for KCNN2
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    Novus Biologicals KCNN2 Lysates
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    Cloud-Clone Corp. Proteins for KCNN2

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    Abcam antibodies for KCNN2 (Q9H2S1, Q6PJI0)
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    LSBio Antibodies in human, mouse, rat for KCNN2

    KCNN2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for KCNN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels
    KCa: Voltage-gated ion channels / Potassium channels, calcium-activated

    IUPHAR Guide to PHARMACOLOGY protein family classification: KCa2.2
    Calcium-activated potassium channels

    3 InterPro protein domains:
     IPR004178 CaM-bd_dom
     IPR015449 K_chnl_Ca-activ_SK
     IPR013099 2pore_dom_K_chnl_dom

    Graphical View of Domain Structure for InterPro Entry Q9H2S1

    ProtoNet protein and cluster: Q9H2S1

    3 Blocks protein domains:
    IPB004178 Calmodulin binding domain
    IPB011996 SK channel region
    IPB013099 Ion transport 2


    UniProtKB/Swiss-Prot: KCNN2_HUMAN, Q9H2S1
    Similarity: Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily


    KCNN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNN2_HUMAN, Q9H2S1
    Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed
    by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of
    synaptic afterhyperpolarization. The channel is blocked by apamin

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005516calmodulin binding IEA--
    GO:0015269calcium-activated potassium channel activity IDA17110593
    GO:0016286small conductance calcium-activated potassium channel activity TAS10991935
    GO:0042803protein homodimerization activity IPI17110593
         
    KCNN2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KCNN2:
     Decreased nuclei size in G2M 

         8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Kcnn2):
     behavior/neurological  growth/size/body  homeostasis/metabolism  integument  mortality/aging 
     nervous system  normal  reproductive system 

    KCNN2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Kcnn2tm1.1Jpad for KCNN2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNN2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KCNN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCNN2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCNN2

    miRNA
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    miRTarBase miRNAs that target KCNN2:
    hsa-mir-26b-5p (MIRT029340)

    Block miRNA regulation of human, mouse, rat KCNN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCNN2 (see all 22):
    hsa-miR-124* hsa-miR-3938 hsa-miR-3616-5p hsa-miR-3942-5p hsa-miR-3660 hsa-miR-519a hsa-miR-1244 hsa-miR-591
    SwitchGear 3'UTR luciferase reporter plasmidKCNN2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KCNN2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): KCNN2 (NM_170775)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNN2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNN2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCNN2_HUMAN, Q9H2S1: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005790smooth endoplasmic reticulum IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane NAS10991935
    GO:0030018Z disc IEA--
    GO:0030315T-tubule IEA--

    KCNN2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNN2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters outward current0.41
    2Insulin secretion
    Insulin secretion0.36
    Ca2+ activated K+ channels0.00
    3Transmission across Chemical Synapses
    Neuronal System0.68
    4Circadian entrainment
    Serotonergic synapse0.33
    5Bile secretion
    Bile secretion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for KCNN2
        BDNF signaling pathway

    1 Reactome Pathway for KCNN2
        Ca2+ activated K+ channels


    3 Kegg Pathways  (Kegg details for KCNN2):
        Serotonergic synapse
    Insulin secretion
    Bile secretion


    KCNN2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including KCNN2: 
              Neuronal Ion Channels in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KCNN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for KCNN2 (Q9H2S13 ENSP000002647734) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=3 STRING: ENSP00000349467
    CALM2P621583I2D: score=3 
    CALM3P621583I2D: score=3 
    MYL12BO149503, ENSP000002375004I2D: score=1 STRING: ENSP00000237500
    KCNN3ENSP000002719154STRING: ENSP00000271915
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006813potassium ion transport NAS10991935
    GO:0007268synaptic transmission TAS--
    GO:0071805potassium ion transmembrane transport IDA17110593
    GO:1901379regulation of potassium ion transmembrane transport IDA17110593

    KCNN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNN2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PaxillineSERCA ATPase blocker. Also potent BKCa channel blocker[57186-25-1]
    TRAM 34Highly selective KCa3.1 channel blocker[289905-88-0]
    CyPPAActivator of KCa2.2 and KCa2.3 channels[73029-73-9]
    ApaminKCa2 channel blocker (small conductance)[24345-16-2]
    IberiotoxinKCa channel blocker (big conductance)[129203-60-7]

    1 HMDB Compound for KCNN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for KCNN2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Miconazole-- 22916-47-8targetinhibitor8760033 1376313

    Selected IUPHAR Ligands for KCNN2 (KCa2.2) (see all 13)    About this table
    LigandTypeActionAffinityPubmed IDs
    leiurotoxin I
    Pore BlockerAntagonist9.5 - 9.711527975 10713270
    UCL1684
    Pore BlockerAntagonist9.611278890
    UCL1848
    Pore BlockerAntagonist9.611278890
    apamin
    Pore BlockerAntagonist9.410713270
    Lei-Dab7
    Pore BlockerAntagonist8.311527975
    P05
    Pore BlockerAntagonist7.711527975
    Ca2+
    ActivatorAgonist6.2 - 6.516239218 9774106 10991935
    NS8593
    Gating inhibitorAntagonist6.216926279
    NS309
    ActivatorAgonist6.215471565 16239218
    (+)-tubocurarine
    Pore BlockerAntagonist5.710713270

    6 Novoseek inferred chemical compound relationships for KCNN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    scyllatoxin 89.5 1 10991935 (1)
    apamin 83.6 4 17142458 (1), 10991935 (1), 12382077 (1), 15362045 (1)
    d-tubocurarine 70.7 1 10991935 (1)
    potassium 61.3 5 12850554 (1), 12020846 (1), 11146124 (1), 15127180 (1) (see all 5)
    glutamate 27.4 1 17202472 (1)
    calcium 19 6 20417625 (1), 16055520 (1), 19913909 (1), 10991935 (1) (see all 6)



    KCNN2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KCNN2 gene (3 alternative transcripts): 
    NM_001278204.1  NM_021614.3  NM_170775.2  

    Unigene Cluster for KCNN2:

    Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
    Hs.98280  [show with all ESTs]
    Unigene Representative Sequence: NM_021614
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512097 ENST00000507750 ENST00000503706(uc003kqp.3 uc010jcg.3)
    ENST00000505491 ENST00000506812 ENST00000264773(uc003kqo.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate KCNN2 (see all 22):
    hsa-miR-124* hsa-miR-3938 hsa-miR-3616-5p hsa-miR-3942-5p hsa-miR-3660 hsa-miR-519a hsa-miR-1244 hsa-miR-591
    SwitchGear 3'UTR luciferase reporter plasmidKCNN2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): KCNN2 (NM_170775)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNN2
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      QuantiTect SYBR Green Assays in human, mouse, rat KCNN2
      QuantiFast Probe-based Assays in human, mouse, rat KCNN2

    Additional mRNA sequence: 

    AF239613.1 AF397175.1 AK289948.1 AY258141.1 BC015371.2 BC040722.1 BC117454.1 BC117456.1 

    5 DOTS entries:

    DT.202021  DT.92420843  DT.97837638  DT.102822924  DT.95294677 

    Selected AceView cDNA sequences (see all 37):

    BF437112 AA418096 AK090521 AI271784 BE671791 BI913571 NM_021614 BM542061 
    AF239613 AI339865 BF527328 NM_170775 BG477734 BC040722 AF397175 BC015371 
    BQ436858 BG334529 BV206914 BX283397 BG769522 BE704259 AY258141 BE276011 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KCNN2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                                      -                           
    SP2:                    -                                             
    SP3:                                                                  


    ECgene alternative splicing isoforms for KCNN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    KCNN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTTCAAAC
    KCNN2 Expression
    About this image


    KCNN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epithelial Cells
             Biliary Epithelial Cells Intrahepatic Biliary Tree
     
     Liver (Hepatobiliary System)
             Biliary Epithelial Cells Intrahepatic Biliary Tree
     
     Adrenal Gland (Endocrine System)
    KCNN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98280

    UniProtKB/Swiss-Prot: KCNN2_HUMAN, Q9H2S1
    Tissue specificity: Expressed in atrial myocytes (at protein level). Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including KCNN2: 
              Neuronal Ion Channels in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for KCNN2
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    QuantiFast Probe-based Assays in human, mouse, rat KCNN2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KCNN2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnn25 potassium intermediate/small conductance calcium-activated more   --   18 (24.34 cM) 45268860 
    chicken
    (Gallus gallus)
    Aves SK26
    Gallus gallus potassium intermediate/small conduct...
    94(a)
    1 ↔ 1
    Z(73093353-73183582)
    lizard
    (Anolis carolinensis)
    Reptilia KCNN26
    potassium intermediate/small conductance calcium-a...
    67(a)
    1 ↔ 1
    GL343193.1(7686908-7779821)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.14992 Xenopus laevis transcribed sequence with strong similarity more 87.58(n)    BG359907.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-76p7.51 si:dkey-76p7.5 76.12(n)
    87.16(a)
      564698  XM_688028.4  XP_693120.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta SK3 calcium-activated potassium channel 65(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea C03F11.13 noninactivating potassium channel
    (weak)
    39(a)
    (best of 2)
      X(5426007-5429417)   --


    ENSEMBL Gene Tree for KCNN2 (if available)
    TreeFam Gene Tree for KCNN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNN2 gene
    KCNN42  KCNN12  KCNN32  
    4 SIMAP similar genes for KCNN2 using alignment to 2 protein entries:     KCNN2_HUMAN (see all proteins):
    KCNN3    SK3    KCNN1    KCNN4

    KCNN2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNN2 (see all 2679)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs623814641,2
    C,F--108878957(+) TAAGAT/CGGAGC 1 -- us2k13Minor allele frequency- C:0.05NA WA 240
    rs1434071401,2
    --108879002(+) GTGTTA/GGTACA 1 -- us2k10--------
    rs1910448301,2
    --108879084(+) AAATAA/CATAAA 1 -- us2k10--------
    rs1833553091,2
    --108879098(+) TGATAC/TCGAAC 1 -- us2k10--------
    rs1141661451,2
    F--108879124(+) GCACTG/CTCCGT 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1465686311,2
    --108879183(+) GCTGCA/GACTAC 1 -- us2k10--------
    rs1880968641,2
    --108879212(+) GCCAGA/GCCCCT 1 -- us2k10--------
    rs38120641,2
    C--108879333(+) AGAAGA/GGCAGC 1 -- us2k1 tfbs31Minor allele frequency- G:0.00NA 2
    rs1920315211,2
    --108879450(+) TGAGCA/GCCAGA 1 -- us2k10--------
    rs1844857591,2
    --108879595(+) ACTGCA/GGGGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNN2 (113696642 - 113832337 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for KCNN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv882728CNV Loss21882294
    nsv830452CNV Loss17160897
    esv8535CNV Gain19470904
    nsv882729CNV Gain21882294
    nsv830451CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNN2
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605879    OMIM disorders: --

    8 diseases for KCNN2:    
    About MalaCards
    hirschsprung's disease    neuronitis    medulloblastoma    hypoxia
    schizophrenia    melanoma    obesity    hiv-1


    KCNN2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KCNN2
    Human Genome Epidemiology (HuGE) Navigator: KCNN2 (1 document)

    Export disorders for KCNN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNN2 gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with KCNN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization. (PubMed id 10991935)1, 2, 9 Desai R.... Attali B. (J. Biol. Chem. 2000)
    2. Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts. (PubMed id 13679367)1, 2, 9 Xu Y....Chiamvimonvat N. (J. Biol. Chem. 2003)
    3. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (PubMed id 16382103)1, 3 Wei A.D....Wulff H. (Pharmacol. Rev. 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Distribution of Ca2+-activated K channels, SK2 and SK3, in the normal and Hirschsprung's disease bowel. (PubMed id 12778407)1, 9 Piotrowska A.P....Puri P. (J. Pediatr. Surg. 2003)
    6. Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain. (PubMed id 11146124)1, 9 Rimini R....Terstappen G.C. (Brain Res. Mol. Brain Res. 2000)
    7. Calcium-dependent regulation of secretion in biliary epithelial cells: the role of apamin-sensitive SK channels. (PubMed id 15362045)1, 9 Feranchak A.P....Fitz J.G. (Gastroenterology 2004)
    8. SK2 encodes the apamin-sensitive Ca(2+)-activated K(+) channels in the human leukemic T cell line, Jurkat. (PubMed id 10713270)1, 9 JAoger H....Grissmer S. (FEBS Lett. 2000)
    9. Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel). (PubMed id 19815520)1, 9 Lu L....Chiamvimonvat N. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    10. Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. (PubMed id 11527975)1, 9 Shakkottai V.G....Chandy K.G. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3781 HGNC: 6291 AceView: KCNN2 Ensembl:ENSG00000080709 euGenes: HUgn3781
    ECgene: KCNN2 Kegg: 3781 H-InvDB: KCNN2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCNN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCNN2 gene:
    Search GeneIP for patents involving KCNN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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