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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNN2 Gene

protein-coding   GIFtS: 62
GCID: GC05P113725

potassium intermediate/small conductance calcium-activated...
 Explore 7 diseases affiliated with
KCNN2 via
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Biological research products
for KCNN2    

Aliases
for KCNN2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Potassium Intermediate/Small Conductance Calcium-Activated Channel,
Subfamily N, Member 21 2
     SKCA22
KCa2.21 2 3     Apamin-Sensitive Small-Conductance Ca2+-Activated Potassium Channel2
SK22 3 5     Small Conductance Calcium-Activated Potassium Channel Protein 22
HSK21     SKCa23
SKCa 22 3     

External Ids:    HGNC: 62911   Entrez Gene: 37812   Ensembl: ENSG000000807097   OMIM: 6058795   UniProtKB: Q9H2S13   

Export aliases for KCNN2 gene to outside databases

Previous GC identifers: GC05P113302 GC05P114100 GC05P113728 GC05P113774 GC05P108880


Summaries
for KCNN2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KCNN2:
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several
seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is
kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this
gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing
to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a
voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of
the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCNN2_HUMAN, Q9H2S1
Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by
membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of
synaptic afterhyperpolarization. The channel is blocked by apamin

summary for KCNN2:
Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+
ions across biological membranes. They are broadly classified into three subtypes, SK, IK and BK channels,
based on their conductance (small, intermediate and big conductance respectively). The small conductance KCa
channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance
KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both
play important roles in many processes involving Ca2+-dependent signalling in both electrically excitable
and non-excitable cells. The BK family of KCa channels (also known as Slo or Maxi-K channels) are also
voltage-sensitive and include KCa1.1 (Slo1), KCa4.1 (Slo2.2), KCa4.2 (Slo2.1) and KCa5.1 (Slo3). These
channels do not require calmodulin for activation as they contain three direct bivalent cation binding
sites.

Gene Wiki entry for KCNN2


Genomic Views
for KCNN2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNN2 gene promoter:
         Elk-1   AML1a   CUTL1   LCR-F1   E4BP4   Evi-1   PPAR-gamma1   Nkx6-1   PPAR-gamma2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q22.3   Ensembl cytogenetic band:  5q22.3   HGNC cytogenetic band: 5q22.3

KCNN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNN2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P113725:  view genomic region     (about GC identifiers)

Start:
 113,696,666 bp from pter      End:
 113,832,321 bp from pter
Size:
 135,656 bases      Orientation:
 plus strand

Proteins
for KCNN2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCNN2_HUMAN, Q9H2S1 (See protein sequence)
Recommended Name: Small conductance calcium-activated potassium channel protein 2  
Size: 579 amino acids; 63760 Da
Subunit: Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit
which regulates the channel activity through calcium-binding (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A6NF94 Q0VFZ4 Q6PJI0
Alternative splicing: 2 isoforms:  Q9H2S1-1   Q9H2S1-2   

Explore the universe of human proteins at neXtProt for KCNN2: NX_Q9H2S1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H2S1

    • KCNN2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_067627.2  NP_740721.1  

    ENSEMBL proteins: 
     ENSP00000427120   ENSP00000264773   ENSP00000421439   ENSP00000421095  
    Reactome Protein details: Q9H2S1
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    Novus Biologicals KCNN2 Lysates
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    Uscn Proteins for KCNN2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane NAS10991935
    GO:0030018Z disc IEA--
    GO:0030315T-tubule IEA--


    KCNN2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for KCNN2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCNN2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR004178 CaM-bd_dom
     IPR015449 K_chnl_Ca-activ_SK
     IPR013099 Ion_trans_2

    Graphical View of Domain Structure for InterPro Entry Q9H2S1

    ProtoNet protein and cluster: Q9H2S1

    3 Blocks protein families:
    IPB004178 Calmodulin binding domain
    IPB011996 SK channel region
    IPB013099 Ion transport 2


    UniProtKB/Swiss-Prot: KCNN2_HUMAN, Q9H2S1
    Similarity: Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily


    Function
    for KCNN2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCNN2_HUMAN, Q9H2S1
    Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by
    membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of
    synaptic afterhyperpolarization. The channel is blocked by apamin

    miRNA
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    hsa-miR-124* hsa-miR-3938 hsa-miR-3616-5p hsa-miR-3942-5p hsa-miR-3660 hsa-miR-519a hsa-miR-1244 hsa-miR-591
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    Inhib. RNA
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    Gene Editing
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
    GO:0015269calcium-activated potassium channel activity IDA17110593
    GO:0016286small conductance calcium-activated potassium channel activity TAS10991935
    GO:0042803protein homodimerization activity IPI17110593


    KCNN2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for KCNN2:
     Decreased nuclei size in G2M 

    Animal Models:
         Mouse knock-out Kcnn2tm1.1Jpad for KCNN2
         8 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Kcnn2):
     behavior/neurological  growth/size  homeostasis/metabolism  integument  mortality/aging 
     nervous system  normal  reproductive system 

    KCNN2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KCNN2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Potassium Channels
    		Potassium Channels1.00
    		Potassium transporters: outward current0.42
    2Ca2+ activated K+ channels
    		Ca2+ activated K+ channels1.00
    3Bile secretion
    		Bile secretion1.00
    4Transmission across Chemical Synapses
    		Neuronal System0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for KCNN2
        Potassium transporters- outward current


    3        Reactome Pathways for KCNN2
        Potassium Channels
    Ca2+ activated K+ channels
    Neuronal System


    1         Kegg Pathway  (Kegg details for KCNN2):
        Bile secretion


    KCNN2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/9 Interacting proteins for KCNN2 (Q9H2S13 ENSP000002647734) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=3 STRING: ENSP00000349467
    CALM2P621583I2D: score=3 
    CALM3P621583I2D: score=3 
    MYL12BO149503I2D: score=1 
    KCNN1ENSP000002222494STRING: ENSP00000222249
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport NAS10991935
    GO:0007268synaptic transmission TAS--
    GO:0071805potassium ion transmembrane transport IDA17110593
    GO:1901379regulation of potassium ion transmembrane transport IDA17110593


    KCNN2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCNN2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCNN2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNN2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    UCL 1684Highly potent blocker of SKCa[199934-16-2]
    Apamin K+ channel blocker (small conductance, Ca2+-dependent) [24345-16-2]
    4-AminopyridineNon-selective KV channel blocker[504-24-5]

    1 HMDB Compound for KCNN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for KCNN2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Miconazole-- 22916-47-8targetinhibitor8760033 1376313

    6 Novoseek chemical compound relationships for KCNN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    scyllatoxin 89.5 1 10991935 (1)
    apamin 83.6 4 17142458 (1), 10991935 (1), 12382077 (1), 15362045 (1)
    d-tubocurarine 70.7 1 10991935 (1)
    potassium 61.3 5 12850554 (1), 12020846 (1), 11146124 (1), 15127180 (1) (see all 5)
    glutamate 27.4 1 17202472 (1)
    calcium 19 6 20417625 (1), 16055520 (1), 19913909 (1), 10991935 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about KCNN2 

    Transcripts
    for KCNN2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCNN2 gene (2 alternative transcripts): 
    NM_021614.2  NM_170775.1  

    Unigene Cluster for KCNN2:

    Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
    Hs.98280  [show with all ESTs]
    Unigene Representative Sequence: NM_021614
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512097 ENST00000264773(uc003kqo.3) ENST00000507750 ENST00000503706(uc003kqp.3 uc010jcg.3)
    ENST00000505491 ENST00000506812

    miRNA
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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNN2 (see all 22):
    hsa-miR-124* hsa-miR-3938 hsa-miR-3616-5p hsa-miR-3942-5p hsa-miR-3660 hsa-miR-519a hsa-miR-1244 hsa-miR-591
    SwitchGear 3'UTR luciferase reporter plasmid: KCNN2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF239613.1 AF397175.1 AK289948.1 AY258141.1 BC015371.2 BC040722.1 BC117454.1 BC117456.1 

    5 DOTS entries:

    DT.202021  DT.92420843  DT.97837638  DT.102822924  DT.95294677 

    24/37 AceView cDNA sequences (see all 37):

    BI913571 AA418096 BE671791 NM_021614 AI271784 BF437112 AK090521 AI339865 
    BG334529 AF239613 BC040722 NM_170775 BQ436858 BX283397 BG769522 BC015371 
    BG477734 BE704259 AY258141 BM542061 BV206914 BF527328 AF397175 BE276011 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KCNN2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                                      -                           
    SP2:                    -                                             
    SP3:                                                                  


    ECgene alternative splicing isoforms for KCNN2

    Expression
    for KCNN2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACTTCAAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KCNN2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverIntrahepatic Biliary TreeBiliary Epithelial CellsLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KCNN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNN2

    SOURCE GeneReport for Unigene cluster: Hs.98280

    UniProtKB/Swiss-Prot: KCNN2_HUMAN, Q9H2S1
    Tissue specificity: Widely expressed

        SABiosciences Expression via Pathway-Focused PCR Array including KCNN2: 
              Neuronal Ion Channels in human mouse rat

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    In Situ
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    Orthologs
    for KCNN2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KCNN2 gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Kcnn21 , 5 potassium intermediate/small conductance calcium-activated more1, 5 93.72(n)1
    99.13(a)1    		   18 (24.34 cM)5
    1404921  NM_080465.21  NP_536713.11 
     455601545 
    chicken
    (Gallus gallus)    		 Aves KCNN21 potassium intermediate/small conductance calcium-activated more 87.94(n)
    94.58(a)    		   395579  NM_204798.1  NP_990129.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KCNN26
    		 --
    		 69(a)
    		 1 ↔ 1
    		 GL343193.1(7687072-7779821)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.14992 Xenopus laevis transcribed sequence with strong similarity more 87.58(n)    BG359907.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5646981 small conductance calcium-activated potassium channel more 76.72(n)
    88.48(a)    		   564698  XM_688028.3  XP_693120.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta SK3 calcium-activated potassium channel 65(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea C03F11.13 noninactivating potassium channel (weak) 39(a)
    (best of 2)    		   X(5426007-5429417)   --


    ENSEMBL Gene Tree for KCNN2 (if available)
    TreeFam Gene Tree for KCNN2 (if available) 

    Paralogs
    for KCNN2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNN2 gene
    KCNN42  KCNN12  KCNN32  
    5 SIMAP similar genes for KCNN2 using alignment to 3 protein entries:     KCNN2_HUMAN (see all proteins):
    SK2    KCNN3    SK3    KCNN1    KCNN4

    KCNN2 for paralogs           About GeneDecksing



    Genomic Variants
    for KCNN2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/61 NCBI SNPs in KCNN2 are shown (see all 61)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs114050821,2
    		C,--113697348(+) CCCCCT/-GGCCA 1 -- us2k13Minor allele frequency- -:0.00NA CSA 6
    rs58706051,2
    		C,--113704567(+) TTTCA-/TTTTTT 1 -- int10--------
    rs623814691,2
    		--113715129(+) TATATA/GACATA 1 -- int12Minor allele frequency- G:0.06NA 122
    rs351632921,2
    		C,F,--113715148(+) TTATAT/GAATAT 1 -- int13Minor allele frequency- G:0.33NA 6
    rs1912220521,2
    		--113715180(+) TTATAG/TAATAT 1 -- int10--------
    rs623814701,2
    		--113715209(+) TATTTA/GTAGAA 1 -- int10--------
    rs562592751,2
    		--113715302(+) ATATTA/TTAGAA 1 -- int10--------
    rs561692671,2
    		--113715363(+) TATTTA/GTAGAA 1 -- int10--------
    rs749872961,2
    		C--113719162(+) AATGC-/TTTTT 
     TTTTTTT    TTTTT     		1 -- int10--------
    rs354853291,2
    		C--113721879(+) AAAAA-/AGTGAA 1 -- int11Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for KCNN2 (113696666 - 113832321 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for KCNN2
         1 Indel: 60548

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    Disorders / Diseases
    for KCNN2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCNN2 for disorders           About GeneDecksing

    OMIM gene information: 605879    OMIM disorders: --

    7 diseases for KCNN2:    About MalaCards
    neuronitis    atrial fibrillation    hirschsprung's disease    medulloblastoma
    hypoxia    schizophrenia    melanoma

    Human Genome Epidemiology (HuGE) Navigator: KCNN2 (1 document)

    Export disorders for KCNN2 gene to outside databases

    Publications
    for KCNN2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNN2 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with KCNN2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization. (PubMed id 10991935)1, 2, 9 Desai R.... Attali B. (2000)
    2. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (PubMed id 16382103)1, 3 Wei A.D....Wulff H. (2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Distribution of Ca2+-activated K channels, SK2 and SK3, in the normal and Hirschsprung's disease bowel. (PubMed id 12778407)1, 9 Piotrowska A.P....Puri P. (2003)
    5. Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain. (PubMed id 11146124)1, 9 Rimini R....Terstappen G.C. (2000)
    6. Calcium-dependent regulation of secretion in biliary epithelial cells: the role of apamin-sensitive SK channels. (PubMed id 15362045)1, 9 Feranchak A.P....Fitz J.G. (2004)
    7. SK2 encodes the apamin-sensitive Ca(2+)-activated K(+) channels in the human leukemic T cell line, Jurkat. (PubMed id 10713270)1, 9 Jager H....Grissmer S. (2000)
    8. Alpha-actinin2 cytoskeletal protein is required for t he functional membrane localization of a Ca2+-activated K+ channel (SK2 channel ). (PubMed id 19815520)1, 9 Lu L....Chiamvimonvat N. (2009)
    9. Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts. (PubMed id 13679367)1, 9 Xu Y....Chiamvimonvat N. (2003)
    10. Decreased expression of small-conductance Ca2+-activat ed K+ channels SK1 and SK2 in human chronic atrial fibrillation. (PubMed id 22154908)1 Yu T....Lin Q. (2012)

    External Searches for KCNN2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KCNN2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3781 HGNC: 6291 AceView: KCNN2 Ensembl:ENSG00000080709 euGenes: HUgn3781
    ECgene: KCNN2 Kegg: 3781 H-InvDB: KCNN2

    Other Databases showing KCNN2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCNN2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNN2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCNN2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCNN2 gene:
    Search GeneIP for patents involving KCNN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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