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Aliases for KCNN2 Gene

Aliases for KCNN2 Gene

  • Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 2 2 3
  • SK2 3 4 6
  • Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 2 2 3
  • Small Conductance Calcium-Activated Potassium Channel 2 2 3
  • SKCa 2 3 4
  • KCa2.2 3 4
  • SKCA2 3 4
  • Apamin-Sensitive Small-Conductance Ca2+-Activated Potassium Channel 3
  • Small Conductance Calcium-Activated Potassium Channel Protein 2 3
  • HSK2 3

External Ids for KCNN2 Gene

Summaries for KCNN2 Gene

Entrez Gene Summary for KCNN2 Gene

  • Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for KCNN2 Gene

KCNN2 (Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 2) is a Protein Coding gene. Among its related pathways are Circadian entrainment and Transmission across Chemical Synapses. GO annotations related to this gene include protein homodimerization activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNN1.

UniProtKB/Swiss-Prot for KCNN2 Gene

  • Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin

Tocris Summary for KCNN2 Gene

  • Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes, SK, IK and BK channels, based on their conductance (small, intermediate and big conductance respectively). The small conductance KCa channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both play important roles in many processes involving Ca2+-dependent signalling in both electrically excitable and non-excitable cells. The BK family of KCa channels (also known as Slo or Maxi-K channels) are also voltage-sensitive and include KCa1.1 (Slo1), KCa4.1 (Slo2.2), KCa4.2 (Slo2.1) and KCa5.1 (Slo3). These channels do not require calmodulin for activation as they contain three direct bivalent cation binding sites.

Gene Wiki entry for KCNN2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNN2 Gene

Genomics for KCNN2 Gene

Genomic Location for KCNN2 Gene

Start:
114,360,945 bp from pter
End:
114,496,640 bp from pter
Size:
135,696 bases
Orientation:
Plus strand

Genomic View for KCNN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNN2 Gene

Regulatory Elements for KCNN2 Gene

Proteins for KCNN2 Gene

  • Protein details for KCNN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2S1-KCNN2_HUMAN
    Recommended name:
    Small conductance calcium-activated potassium channel protein 2
    Protein Accession:
    Q9H2S1
    Secondary Accessions:
    • A6NF94
    • Q0VFZ4
    • Q6PJI0
    • Q6X2Y2

    Protein attributes for KCNN2 Gene

    Size:
    579 amino acids
    Molecular mass:
    63760 Da
    Quaternary structure:
    • Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).

    Alternative splice isoforms for KCNN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNN2 Gene

Proteomics data for KCNN2 Gene at MOPED

Post-translational modifications for KCNN2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys401

Other Protein References for KCNN2 Gene

No data available for DME Specific Peptides for KCNN2 Gene

Domains for KCNN2 Gene

Gene Families for KCNN2 Gene

HGNC:
  • KCN :Potassium channels
  • KCa :Voltage-gated ion channels / Potassium channels, calcium-activated
IUPHAR :

UniProtKB/Swiss-Prot:

KCNN2_HUMAN
Family:
  • Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.:
    • Q9H2S1
genes like me logo Genes that share domains with KCNN2: view

Function for KCNN2 Gene

Molecular function for KCNN2 Gene

UniProtKB/Swiss-Prot Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin

Gene Ontology (GO) - Molecular Function for KCNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005516 calmodulin binding IBA --
GO:0015269 calcium-activated potassium channel activity IDA 17110593
GO:0016286 small conductance calcium-activated potassium channel activity TAS 10991935
GO:0042803 protein homodimerization activity IPI 17110593
genes like me logo Genes that share ontologies with KCNN2: view
genes like me logo Genes that share phenotypes with KCNN2: view

Animal Models for KCNN2 Gene

MGI Knock Outs for KCNN2:

miRNA for KCNN2 Gene

miRTarBase miRNAs that target KCNN2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KCNN2 Gene

Localization for KCNN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNN2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNN2 Gene COMPARTMENTS Subcellular localization image for KCNN2 gene
Compartment Confidence
plasma membrane 4
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KCNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005790 smooth endoplasmic reticulum IEA --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane NAS 10991935
GO:0030018 Z disc IEA --
GO:0030315 T-tubule IEA --
genes like me logo Genes that share ontologies with KCNN2: view

Pathways for KCNN2 Gene

genes like me logo Genes that share pathways with KCNN2: view

Pathways by source for KCNN2 Gene

1 BioSystems pathway for KCNN2 Gene
3 KEGG pathways for KCNN2 Gene

Interacting Proteins for KCNN2 Gene

Gene Ontology (GO) - Biological Process for KCNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006813 potassium ion transport NAS 10991935
GO:0007268 synaptic transmission TAS --
GO:0071805 potassium ion transmembrane transport IDA 17110593
GO:1901379 regulation of potassium ion transmembrane transport IDA 17110593
genes like me logo Genes that share ontologies with KCNN2: view

Compounds for KCNN2 Gene

(5) Tocris Compounds for KCNN2 Gene

Compound Action Cas Number
Apamin KCa2 channel blocker (small conductance) [24345-16-2]
CyPPA Activator of KCa2.2 and KCa2.3 channels [73029-73-9]
Iberiotoxin KCa channel blocker (big conductance) [129203-60-7]
Paxilline SERCA ATPase blocker. Also potent BKCa channel blocker [57186-25-1]
TRAM 34 Highly selective KCa3.1 channel blocker [289905-88-0]

(1) HMDB Compounds for KCNN2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for KCNN2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Miconazole
22916-47-8 target inhibitor

(13) IUPHAR Ligand for KCNN2 Gene

Ligand Type Action Affinity Pubmed IDs
UCL1684 Pore Blocker None 9.1
UCL1848 Pore Blocker Antagonist 9
apamin Pore Blocker Antagonist 8.1
P05 Pore Blocker Agonist 7.6
leiurotoxin I Pore Blocker Antagonist 7.1
NS8593 Gating inhibitor Antagonist 6.4
CyPPA Activator Agonist 5.3
Lei-Dab7 Pore Blocker Antagonist 5.2
(+)-tubocurarine Antagonist Antagonist 5.2
DC-EBIO Activator Agonist 4.9
Ca2+ Antagonist Antagonist
NS309 Activator Agonist
EBIO Activator Agonist

(6) Novoseek inferred chemical compound relationships for KCNN2 Gene

Compound -log(P) Hits PubMed IDs
scyllatoxin 89.5 1
apamin 83.6 4
d-tubocurarine 70.7 1
potassium 61.3 5
glutamate 27.4 1
genes like me logo Genes that share compounds with KCNN2: view

Transcripts for KCNN2 Gene

Unigene Clusters for KCNN2 Gene

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2: -
SP3:

Relevant External Links for KCNN2 Gene

GeneLoc Exon Structure for
KCNN2
ECgene alternative splicing isoforms for
KCNN2

Expression for KCNN2 Gene

mRNA expression in normal human tissues for KCNN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNN2 Gene

This gene is overexpressed in Adrenal Gland (10.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCNN2 Gene

SOURCE GeneReport for Unigene cluster for KCNN2 Gene Hs.98280

mRNA Expression by UniProt/SwissProt for KCNN2 Gene

Q9H2S1-KCNN2_HUMAN
Tissue specificity: Expressed in atrial myocytes (at protein level). Widely expressed.
genes like me logo Genes that share expressions with KCNN2: view

Orthologs for KCNN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNN2 36
  • 99.71 (n)
  • 99.65 (a)
KCNN2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNN2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNN2 37
  • 67 (a)
OneToOne
LOC474640 36
  • 94.72 (n)
  • 97.48 (a)
mouse
(Mus musculus)
Mammalia Kcnn2 16
Kcnn2 37
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNN2 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 66 (a)
OneToMany
-- 37
  • 61 (a)
OneToMany
-- 37
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100910229 36
  • 92.22 (n)
  • 97.47 (a)
chicken
(Gallus gallus)
Aves SK2 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNN2 37
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1499 36
zebrafish
(Danio rerio)
Actinopterygii KCNN2 37
  • 86 (a)
OneToOne
si:dkey-76p7.5 36
  • 76.12 (n)
  • 87.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta SK 37
  • 33 (a)
OneToMany
SK 38
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea kcnl-1 37
  • 24 (a)
ManyToMany
kcnl-2 37
  • 30 (a)
ManyToMany
kcnl-3 37
  • 24 (a)
ManyToMany
kcnl-4 37
  • 26 (a)
ManyToMany
C03F11.1 38
  • 39 (a)
C53A5.5 38
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 64 (a)
OneToMany
Species with no ortholog for KCNN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KCNN2 Gene

ENSEMBL:
Gene Tree for KCNN2 (if available)
TreeFam:
Gene Tree for KCNN2 (if available)

Paralogs for KCNN2 Gene

Paralogs for KCNN2 Gene

Selected SIMAP similar genes for KCNN2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCNN2: view

Variants for KCNN2 Gene

Sequence variations from dbSNP and Humsavar for KCNN2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs36944 -- 114,360,313(-) CTTTT(A/C)AGAGT upstream-variant-2KB
rs36945 -- 114,361,890(-) GGAGG(A/G)GAATC upstream-variant-2KB, utr-variant-5-prime
rs36946 -- 114,364,685(-) ATGGA(C/T)ACTAA intron-variant
rs36947 -- 114,366,361(-) GTATA(G/T)TGGGT intron-variant
rs36948 -- 114,366,537(-) CATTT(A/G)TTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNN2 Gene

Variant ID Type Subtype PubMed ID
nsv882728 CNV Loss 21882294
nsv830451 CNV Gain+Loss 17160897
nsv882729 CNV Gain 21882294
esv8535 CNV Gain 19470904
nsv830452 CNV Loss 17160897

Relevant External Links for KCNN2 Gene

HapMap Linkage Disequilibrium report
KCNN2

Disorders for KCNN2 Gene

Relevant External Links for KCNN2

Genetic Association Database (GAD)
KCNN2
Human Genome Epidemiology (HuGE) Navigator
KCNN2
genes like me logo Genes that share disorders with KCNN2: view

No data available for UniProtKB/Swiss-Prot for KCNN2 Gene

Publications for KCNN2 Gene

  1. Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization. (PMID: 10991935) Desai R. … Attali B. (J. Biol. Chem. 2000) 3 4 23
  2. Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts. (PMID: 13679367) Xu Y. … Chiamvimonvat N. (J. Biol. Chem. 2003) 3 4 23
  3. Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain. (PMID: 11146124) Rimini R. … Terstappen G.C. (Brain Res. Mol. Brain Res. 2000) 3 23
  4. Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. (PMID: 11527975) Shakkottai V.G. … Chandy K.G. (J. Biol. Chem. 2001) 3 23
  5. Calcium-dependent regulation of secretion in biliary epithelial cells: the role of apamin-sensitive SK channels. (PMID: 15362045) Feranchak A.P. … Fitz J.G. (Gastroenterology 2004) 3 23

Products for KCNN2 Gene

Sources for KCNN2 Gene

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