Aliases for KCNN2 Gene
- Potassium Calcium-Activated Channel Subfamily N Member 2 2 3 5
- Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 2 2 3
- Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 2 2 3
- Small Conductance Calcium-Activated Potassium Channel 2 2 3
- SKCa 2 3 4
- KCa2.2 3 4
External Ids for KCNN2 Gene
Previous GeneCards Identifiers for KCNN2 Gene
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
GeneCards Summary for KCNN2 Gene
KCNN2 (Potassium Calcium-Activated Channel Subfamily N Member 2) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Bile secretion. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ion channel activity. An important paralog of this gene is KCNN3.
UniProtKB/Swiss-Prot for KCNN2 Gene
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
Calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).