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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNN1 Gene

protein-coding   GIFtS: 57
GCID: GC19P018062

Potassium Intermediate/Small Conductance Calcium-Activated...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Intermediate/Small Conductance Calcium-Activated Channel,
Subfamily N, Member 11 2
     Small Conductance Calcium-Activated Potassium Channel Protein 12
KCa2.12 3     SK3
SK12 3     SKCa13
SKCA12     SKCa 13
hSK12     

External Ids:    HGNC: 62901   Entrez Gene: 37802   Ensembl: ENSG000001056427   OMIM: 6029825   UniProtKB: Q929523   

Export aliases for KCNN1 gene to outside databases

Previous GC identifers: GC19P018555 GC19P018454 GC19P017907 GC19P017924 GC19P017925 GC19P017926 GC19P017627


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNN1 Gene:
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for
several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the
AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein
encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal
excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane
protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.
This gene is a member of the KCNN family of potassium channel genes. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNN1 Gene: 
KCNN1 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1) is a protein-coding gene. Diseases associated with KCNN1 include myotonic dystrophy type 1, and myotonic dystrophy, and among its related super-pathways are Voltage gated Potassium channels and Transmission across Chemical Synapses. GO annotations related to this gene include small conductance calcium-activated potassium channel activity and calmodulin binding.

UniProtKB/Swiss-Prot: KCNN1_HUMAN, Q92952
Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed
by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of
synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity)

summary for KCNN1 Gene:
Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+
ions across biological membranes. They are broadly classified into three subtypes, SK, IK and BK channels,
based on their conductance (small, intermediate and big conductance respectively). The small conductance KCa
channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance
KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both
play important roles in many processes involving Ca2+-dependent signalling in both electrically excitable
and non-excitable cells. The BK family of KCa channels (also known as Slo or Maxi-K channels) are also
voltage-sensitive and include KCa1.1 (Slo1), KCa4.1 (Slo2.2), KCa4.2 (Slo2.1) and KCa5.1 (Slo3). These
channels do not require calmodulin for activation as they contain three direct bivalent cation binding
sites.

Gene Wiki entry for KCNN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNN1 gene promoter:
         ER-alpha   GR   GR-beta   MIF-1   AP-4   Egr-4   c-Rel   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.1

KCNN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNN1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P018062:  view genomic region     (about GC identifiers)

Start:
18,062,111 bp from pter      End:
18,109,930 bp from pter
Size:
47,820 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCNN1_HUMAN, Q92952 (See protein sequence)
Recommended Name: Small conductance calcium-activated potassium channel protein 1  
Size: 543 amino acids; 59987 Da
Subunit: Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit
which regulates the channel activity through calcium-binding (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q5KR10 Q6DJU4
Alternative splicing: 2 isoforms:  Q92952-1   Q92952-2   

Explore the universe of human proteins at neXtProt for KCNN1: NX_Q92952

Explore proteomics data for KCNN1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92952

  • KCNN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCNN1 Protein Expression
    REFSEQ proteins: NP_002239.2  Reactome Protein details: Q92952
    Human Recombinant Protein Products for KCNN1: 
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    Cloud-Clone Corp. Proteins for KCNN1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex TAS8781233

    KCNN1 for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for KCNN1 

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    Cloud-Clone Corp. ELISAs for KCNN1 
    Cloud-Clone Corp. CLIAs for KCNN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KCN: Potassium channels
    KCa: Voltage-gated ion channels / Potassium channels, calcium-activated

    IUPHAR Guide to PHARMACOLOGY protein family classification: KCa2.1 
    Calcium-activated potassium channels

    3 InterPro protein domains:
     IPR004178 CaM-bd_dom
     IPR015449 K_chnl_Ca-activ_SK
     IPR013099 Ion_trans_2

    Graphical View of Domain Structure for InterPro Entry Q92952

    ProtoNet protein and cluster: Q92952

    3 Blocks protein domains:
    IPB004178 Calmodulin binding domain
    IPB011996 SK channel region
    IPB013099 Ion transport 2


    UniProtKB/Swiss-Prot: KCNN1_HUMAN, Q92952
    Similarity: Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily


    KCNN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNN1_HUMAN, Q92952
    Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed
    by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of
    synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity)

         Genatlas biochemistry entry for KCNN1:
    potassium intermediate/small conductance calcium-activated channel,subfamily N member 1,regulating neuronal
    excitabability

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005516calmodulin binding IEA--
    GO:0015269calcium-activated potassium channel activity TAS8781233
    GO:0016286small conductance calcium-activated potassium channel activity IEA--
         
    KCNN1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Kcnn1):
     nervous system  no phenotypic analysis 

    KCNN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Kcnn1tm1.1Jpad for KCNN1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KCNN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KCNN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCNN1 
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    hsa-miR-3926 hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmidKCNN1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KCNN1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters: outward current0.42
    2Transmission across Chemical Synapses
    Neuronal System0.67
    3Insulin secretion
    Insulin secretion0.36
    4Synaptic transmission: ion currents
    Synaptic transmission: ion currents
    5Ca2+ activated K+ channels
    Ca2+ activated K+ channels

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for KCNN1
        Synaptic transmission- ion currents
    Potassium transporters- outward current


    3        Reactome Pathways for KCNN1
        Potassium Channels
    Ca2+ activated K+ channels
    Neuronal System


    1         Kegg Pathway  (Kegg details for KCNN1):
        Insulin secretion


    KCNN1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNN1

    3 Interacting proteins for KCNN1 (Q929523) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629933I2D: score=1 
    MAPK3P273613I2D: score=1 
    UBCP0CG483I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport TAS8781233
    GO:0007268synaptic transmission TAS--

    KCNN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCNN1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNN1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PaxillineSERCA ATPase blocker. Also potent BKCa channel blocker[57186-25-1]
    TRAM 34Highly selective KCa3.1 channel blocker[289905-88-0]
    CyPPAActivator of KCa2.2 and KCa2.3 channels[73029-73-9]
    ApaminKCa2 channel blocker (small conductance)[24345-16-2]
    IberiotoxinKCa channel blocker (big conductance)[129203-60-7]

    1 HMDB Compound for KCNN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for KCNN1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Miconazole-- 22916-47-8targetinhibitor8760033 1376313

    10/13 IUPHAR Ligands for KCNN1 (KCa2.1) (see all 13)    About this table 
    LigandTypeActionAffinityPubmed IDs
    UCL1684
    Pore BlockerNone9.110696100
    UCL1848
    Pore BlockerAntagonist910683185
    apamin
    Pore BlockerAntagonist8.110683185 10696100 15208027
    tamapin
    Pore BlockerAntagonist7.412239213
    leiurotoxin I
    Pore BlockerAntagonist6.5 - 7.110696100 11527975
    Ca2+
    ActivatorAgonist6.2 - 6.58781233 9774106
    NS8593
    Gating inhibitorAntagonist6.416926279
    dequalinium chloride
    Pore BlockerAntagonist6.410683185 10696100
    Lei-Dab7
    Pore BlockerAntagonist5.211527975
    bicuculline
    Pore BlockerAntagonist4.810696100

    10/17 Novoseek inferred chemical compound relationships for KCNN1 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    apamin 88.9 18 17142458 (3), 10696100 (2), 10725258 (1), 11223279 (1) (see all 13)
    dequalinium chloride 81.1 1 10696100 (1)
    scyllatoxin 77.4 1 10696100 (1)
    potassium 76.6 62 10732800 (2), 9774106 (2), 15379997 (2), 12875918 (2) (see all 49)
    sphingosine 74.4 17 20156522 (2), 16522638 (2), 17898040 (1), 16926156 (1) (see all 12)
    charybdotoxin 72.1 2 10725258 (1), 9843105 (1)
    iberiotoxin 65.1 1 10725258 (1)
    d-tubocurarine 65.1 1 10696100 (1)
    clotrimazole 65.1 1 10519135 (1)
    calcium 40.9 27 10204997 (3), 9774106 (2), 15379997 (2), 9326665 (2) (see all 16)

    Search CenterWatch for drugs/clinical trials and news about KCNN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KCNN1 gene: 
    NM_002248.4  

    Unigene Cluster for KCNN1:

    Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
    Hs.158173  [show with all ESTs]
    Unigene Representative Sequence: NM_002248
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000598525 ENST00000594192 ENST00000601725 ENST00000222249(uc002nht.3 uc010xqa.1)


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    Additional mRNA sequence: 

    BC075037.2 U69883.2 

    3 DOTS entries:

    DT.438112  DT.97777878  DT.121438614 

    24/27 AceView cDNA sequences (see all 27):

    NM_002248 BX106650 BI522613 U69883 AA351095 BC075037 AA350009 F09023 
    BM718136 F11363 AA594089 AA325431 BM930603 AI937237 AW594619 BU153891 
    BX393926 D61063 BE504989 BF062198 AI825516 D60120 C15510 D60321 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KCNN1 Expression
    About this image


    See KCNN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNN1

    SOURCE GeneReport for Unigene cluster: Hs.158173
        SABiosciences Expression via Pathway-Focused PCR Arrays including KCNN1: 
              Neuronal Ion Channels in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KCNN1 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnn11 , 5 potassium intermediate/small conductance calcium-activated more1, 5 82.47(n)1
    84.2(a)1
      8 (34.27 cM)5
    840361  NM_032397.21  NP_115773.21 
     708420495 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.147102 Transcribed sequence with moderate similarity to protein more 80.85(n)    BM082635.1 


    ENSEMBL Gene Tree for KCNN1 (if available)
    TreeFam Gene Tree for KCNN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNN1 gene
    5 SIMAP similar genes for KCNN1 using alignment to 1 protein entry:     KCNN1_HUMAN:
    KCNN3    SK3    KCNN2    SK2    KCNN4

    KCNN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1000 SNPs in KCNN1 are shown (see all 1000)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1472627191,2
    --17991420(+) CTCATC/TCCATG 1 -- us2k10--------
    rs1396738251,2
    --17991432(+) GGACAC/TATACC 1 -- us2k10--------
    rs1435800181,2
    --17991447(+) CTGGGC/TCTTTG 1 -- us2k10--------
    rs65122381,2
    C,F,A,H--17991543(+) AAACAA/CAATCA 1 -- us2k124Minor allele frequency- C:0.37NS EA NA WA CSA 2353
    rs116728741,2
    C,F,A,H--17991568(+) CAGCCC/TCCCAG 1 -- us2k15Minor allele frequency- T:0.15NA WA 244
    rs1441917831,2
    --17991736(+) TTTTCC/TCCAGG 1 -- us2k10--------
    rs1860817481,2
    C--17992157(+) AGAGCA/CCTGTG 1 -- us2k10--------
    rs1486876311,2
    --17992250(+) TAGGGA/GGAGAA 1 -- us2k10--------
    rs735263761,2
    C,F--17992349(+) TCGGCC/TTGTGA 1 -- us2k12Minor allele frequency- T:0.07WA 120
    rs72503321,2
    C,F,A,H--17992595(+) GTCACC/TTCTGC 1 -- us2k132Minor allele frequency- N:0.00EA NA NS WA CSA 2988

    HapMap Linkage Disequilibrium report for KCNN1 (18062111 - 18109930 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for KCNN1 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv274435CNV Insertion20981092
    nsv2428CNV Insertion18451855
    dgv3767n71CNV Loss21882294
    dgv3768n71CNV Loss21882294
    nsv911233CNV Loss21882294
    nsv470130CNV Loss18288195
    nsv911214CNV Loss21882294
    nsv911226CNV Loss21882294
    nsv911227CNV Loss21882294
    dgv3769n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602982    OMIM disorders: --

    19 diseases for KCNN1:    About MalaCards
    myotonic dystrophy type 1    myotonic dystrophy    traumatic brain injury    brain injury
    migraine    schizophrenia    neuronitis    fanconi's anemia
    bipolar disorder    muscular dystrophy    anemia    parkinson's disease
    ischemia    ataxia    tuberculosis    retinitis
    alzheimer's disease    endotheliitis    melanoma


    KCNN1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for KCNN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 29.9 4 10732800 (1), 10395217 (1), 10196711 (1)
    glioma 0 1 8051694 (1)


    Export disorders for KCNN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNN1 gene, integrated from 9 sources (see all 94):
    (articles sorted by number of sources associating them with KCNN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1). (PubMed id 10516439)1, 2, 3, 9 Litt M.... Adelman J.P. (1999)
    2. Small-conductance, calcium-activated potassium channels from mammalian brain. (PubMed id 8781233)1, 2, 3 Koehler M.... Adelman J.P. (1996)
    3. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (PubMed id 16382103)1, 3 Wei A.D....Wulff H. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Calmodulin binding to the C-terminus of the small-conductance Ca2+-activated K+ channel hSK1 is affected by alternative splicing. (PubMed id 11258935)1, 9 Zhang B.M....Sullivan R. (2001)
    6. The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. (PubMed id 10683185)1, 9 Shah M. and Haylett D.G. (2000)
    7. Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain. (PubMed id 11146124)1, 9 Rimini R....Terstappen G.C. (2000)
    8. Decreased expression of small-conductance Ca2+-activat ed K+ channels SK1 and SK2 in human chronic atrial fibrillation. (PubMed id 22154908)1 Yu T....Lin Q. (2012)
    9. A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)
    10. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3780 HGNC: 6290 AceView: KCNN1 Ensembl:ENSG00000105642 euGenes: HUgn3780
    ECgene: KCNN1 Kegg: 3780 H-InvDB: KCNN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCNN1 gene:
    Search GeneIP for patents involving KCNN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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