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KCNN1 Gene

protein-coding   GIFtS: 57
GCID: GC19P018062

Potassium Intermediate/Small Conductance Calcium-Activated...

  See KCNN1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Intermediate/Small Conductance Calcium-Activated Channel,
Subfamily N, Member 11 2
     Small Conductance Calcium-Activated Potassium Channel Protein 12
KCa2.12 3     SK3
SK12 3     SKCa13
SKCA12     SKCa 13
hSK12     

External Ids:    HGNC: 62901   Entrez Gene: 37802   Ensembl: ENSG000001056427   OMIM: 6029825   UniProtKB: Q929523   

Export aliases for KCNN1 gene to outside databases

Previous GC identifers: GC19P018555 GC19P018454 GC19P017907 GC19P017924 GC19P017925 GC19P017926 GC19P017627


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNN1 Gene:
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for
several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the
AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein
encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal
excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane
protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.
This gene is a member of the KCNN family of potassium channel genes. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNN1 Gene:
KCNN1 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1) is a protein-coding gene. Diseases associated with KCNN1 include schizophrenia. GO annotations related to this gene include small conductance calcium-activated potassium channel activity and calmodulin binding. An important paralog of this gene is KCNN4.

UniProtKB/Swiss-Prot: KCNN1_HUMAN, Q92952
Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed
by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of
synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity)

summary for KCNN1 Gene:
Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+
ions across biological membranes. They are broadly classified into three subtypes, SK, IK and BK channels,
based on their conductance (small, intermediate and big conductance respectively). The small conductance KCa
channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance
KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both
play important roles in many processes involving Ca2+-dependent signalling in both electrically excitable
and non-excitable cells. The BK family of KCa channels (also known as Slo or Maxi-K channels) are also
voltage-sensitive and include KCa1.1 (Slo1), KCa4.1 (Slo2.2), KCa4.2 (Slo2.1) and KCa5.1 (Slo3). These
channels do not require calmodulin for activation as they contain three direct bivalent cation binding
sites.

Gene Wiki entry for KCNN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNN1 gene promoter:
         ER-alpha   GR   GR-beta   MIF-1   AP-4   Egr-4   c-Rel   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNN1 promoter sequence
   Search Chromatin IP Primers for KCNN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.1

KCNN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNN1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P018062:  view genomic region     (about GC identifiers)

Start:
18,062,102 bp from pter      End:
18,110,889 bp from pter
Size:
48,788 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCNN1_HUMAN, Q92952 (See protein sequence)
Recommended Name: Small conductance calcium-activated potassium channel protein 1  
Size: 543 amino acids; 59987 Da
Subunit: Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit
which regulates the channel activity through calcium-binding (By similarity)
Secondary accessions: Q5KR10 Q6DJU4
Alternative splicing: 2 isoforms:  Q92952-1   Q92952-2   

Explore the universe of human proteins at neXtProt for KCNN1: NX_Q92952

Explore proteomics data for KCNN1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys373
  • Modification sites at PhosphoSitePlus

  • See KCNN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002239.2  
    ENSEMBL proteins: 
     ENSP00000476519   ENSP00000477114  
    Reactome Protein details: Q92952

    KCNN1 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for KCNN1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels
    KCa: Voltage-gated ion channels / Potassium channels, calcium-activated

    IUPHAR Guide to PHARMACOLOGY protein family classification: KCa2.1
    Calcium-activated potassium channels

    3 InterPro protein domains:
     IPR004178 CaM-bd_dom
     IPR015449 K_chnl_Ca-activ_SK
     IPR013099 2pore_dom_K_chnl_dom

    Graphical View of Domain Structure for InterPro Entry Q92952

    ProtoNet protein and cluster: Q92952

    3 Blocks protein domains:
    IPB004178 Calmodulin binding domain
    IPB011996 SK channel region
    IPB013099 Ion transport 2


    UniProtKB/Swiss-Prot: KCNN1_HUMAN, Q92952
    Similarity: Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily


    Find genes that share domains with KCNN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNN1_HUMAN, Q92952
    Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed
    by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of
    synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity)

         Genatlas biochemistry entry for KCNN1:
    potassium intermediate/small conductance calcium-activated channel,subfamily N member 1,regulating neuronal
    excitabability

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005516calmodulin binding IEA--
    GO:0015269calcium-activated potassium channel activity TAS8781233
    GO:0016286small conductance calcium-activated potassium channel activity IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with KCNN1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Kcnn1):
     nervous system  no phenotypic analysis 

    Find genes that share phenotypes with KCNN1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kcnn1tm1.1Jpad for KCNN1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNN1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KCNN1

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCNN1

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    2 qRT-PCR Assays for microRNAs that regulate KCNN1:
    hsa-miR-3926 hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmidKCNN1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: KCNN1 (NM_002248)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCNN1_HUMAN, Q92952: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex TAS8781233
    GO:0016021integral component of membrane ----
    GO:0043025neuronal cell body IEA--

    Find genes that share ontologies with KCNN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNN1 About    
    See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters outward current0.41
    2Insulin secretion
    Insulin secretion0.36
    Ca2+ activated K+ channels0.00
    3Transmission across Chemical Synapses
    Neuronal System0.68
    4Synaptic transmission ion currents
    Synaptic transmission ion currents


    Find genes that share SuperPaths with KCNN1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for KCNN1
        Ca2+ activated K+ channels


    1 Kegg Pathway  (Kegg details for KCNN1):
        Insulin secretion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including KCNN1: 
              Neuronal Ion Channels in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KCNN1

    3 Interacting proteins for KCNN1 (Q929523) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629933I2D: score=1 
    MAPK3P273613I2D: score=1 
    UBCP0CG483I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport TAS8781233
    GO:0007268synaptic transmission TAS--
    GO:0071805potassium ion transmembrane transport TAS8781233

    Find genes that share ontologies with KCNN1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNN1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PaxillineSERCA ATPase blocker. Also potent BKCa channel blocker[57186-25-1]
    TRAM 34Highly selective KCa3.1 channel blocker[289905-88-0]
    CyPPAActivator of KCa2.2 and KCa2.3 channels[73029-73-9]
    ApaminKCa2 channel blocker (small conductance)[24345-16-2]
    IberiotoxinKCa channel blocker (big conductance)[129203-60-7]

    1 HMDB Compound for KCNN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for KCNN1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Miconazole-- 22916-47-8targetinhibitor8760033 1376313

    Selected IUPHAR Ligands for KCNN1 (KCa2.1) (see all 13)    About this table
    LigandTypeActionAffinityPubmed IDs
    UCL1684
    Pore BlockerNone9.110696100
    UCL1848
    Pore BlockerAntagonist910683185
    apamin
    Pore BlockerAntagonist8.110683185 10696100 15208027
    tamapin
    Pore BlockerAntagonist7.412239213
    leiurotoxin I
    Pore BlockerAntagonist6.5 - 7.110696100 11527975
    Ca2+
    ActivatorAgonist6.2 - 6.58781233 9774106
    NS8593
    Gating inhibitorAntagonist6.416926279
    dequalinium chloride
    Pore BlockerAntagonist6.410683185 10696100
    Lei-Dab7
    Pore BlockerAntagonist5.211527975
    bicuculline
    Pore BlockerAntagonist4.810696100

    Selected Novoseek inferred chemical compound relationships for KCNN1 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    apamin 88.9 18 17142458 (3), 10696100 (2), 10725258 (1), 11223279 (1) (see all 13)
    dequalinium chloride 81.1 1 10696100 (1)
    scyllatoxin 77.4 1 10696100 (1)
    potassium 76.6 62 10732800 (2), 9774106 (2), 15379997 (2), 12875918 (2) (see all 49)
    sphingosine 74.4 17 20156522 (2), 16522638 (2), 17898040 (1), 16926156 (1) (see all 12)
    charybdotoxin 72.1 2 10725258 (1), 9843105 (1)
    iberiotoxin 65.1 1 10725258 (1)
    d-tubocurarine 65.1 1 10696100 (1)
    clotrimazole 65.1 1 10519135 (1)
    calcium 40.9 27 10204997 (3), 9774106 (2), 15379997 (2), 9326665 (2) (see all 16)



    Find genes that share compounds with KCNN1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCNN1 gene: 
    NM_002248.4  

    Unigene Cluster for KCNN1:

    Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
    Hs.158173  [show with all ESTs]
    Unigene Representative Sequence: NM_002248
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222249(uc002nht.3 uc010xqa.1) ENST00000594192 ENST00000609922

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    Additional mRNA sequence: 

    BC075037.2 U69883.2 

    3 DOTS entries:

    DT.438112  DT.97777878  DT.121438614 

    Selected AceView cDNA sequences (see all 27):

    NM_002248 BI522613 BX106650 BM930603 F09023 U69883 AA594089 BC075037 
    F11363 AI937237 BM718136 AA350009 AA351095 AA325431 AW594619 BE504989 
    BU153891 BF062198 D61063 BX393926 AI825516 C15510 D60120 D60321 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KCNN1 Expression
    About this image

    KCNN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.158173
        Pathway & Disease-focused RT2 Profiler PCR Arrays including KCNN1: 
              Neuronal Ion Channels in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat KCNN1
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KCNN1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnn11 , 5 potassium intermediate/small conductance calcium-activated more1, 5 81.91(n)1
    83.64(a)1
      8 (34.27 cM)5
    840361  NM_032397.21  NP_115773.21 
     708420495 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.147102 Transcribed sequence with moderate similarity to protein more 80.85(n)    BM082635.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SK3 calcium-activated potassium channel 62(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea C03F11.13 noninactivating potassium channel
    (weak)
    35(a)
    (best of 2)
      X(5426007-5429417)   --


    ENSEMBL Gene Tree for KCNN1 (if available)
    TreeFam Gene Tree for KCNN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for KCNN1 gene
    KCNN42  KCNN22  KCNN32  
    4 SIMAP similar genes for KCNN1 using alignment to 2 protein entries:     KCNN1_HUMAN (see all proteins):
    KCNN3    SK3    KCNN2    KCNN4

    Find genes that share paralogs with KCNN1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNN1 (see all 1000)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1472627191,2
    --17991420(+) CTCATC/TCCATG 1 -- us2k10--------
    rs1396738251,2
    --17991432(+) GGACAC/TATACC 1 -- us2k10--------
    rs1435800181,2
    --17991447(+) CTGGGC/TCTTTG 1 -- us2k10--------
    rs65122381,2
    C,F,A,H--17991543(+) AAACAA/CAATCA 1 -- us2k124Minor allele frequency- C:0.37NS EA NA WA CSA 2353
    rs116728741,2
    C,F,A,H--17991568(+) CAGCCC/TCCCAG 1 -- us2k15Minor allele frequency- T:0.15NA WA 244
    rs1441917831,2
    --17991736(+) TTTTCC/TCCAGG 1 -- us2k10--------
    rs1860817481,2
    C--17992157(+) AGAGCA/CCTGTG 1 -- us2k10--------
    rs1486876311,2
    --17992250(+) TAGGGA/GGAGAA 1 -- us2k10--------
    rs735263761,2
    C,F--17992349(+) TCGGCC/TTGTGA 1 -- us2k12Minor allele frequency- T:0.07WA 120
    rs72503321,2
    C,F,A,H--17992595(+) GTCACC/TTCTGC 1 -- us2k132Minor allele frequency- N:0.00EA NA NS WA CSA 2988

    HapMap Linkage Disequilibrium report for KCNN1 (18062102 - 18110889 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KCNN1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv274435CNV Insertion20981092
    nsv2428CNV Insertion18451855
    dgv3767n71CNV Loss21882294
    dgv3768n71CNV Loss21882294
    nsv911233CNV Loss21882294
    nsv470130CNV Loss18288195
    nsv911214CNV Loss21882294
    nsv911226CNV Loss21882294
    nsv911227CNV Loss21882294
    dgv3769n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNN1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602982    OMIM disorders: --

    1 disease for KCNN1:    
    About MalaCards
    schizophrenia


    Find genes that share disorders with KCNN1           About GenesLikeMe

    2 Novoseek inferred disease relationships for KCNN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 29.9 4 10732800 (1), 10395217 (1), 10196711 (1)
    glioma 0 1 8051694 (1)


    Export disorders for KCNN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for KCNN1 gene, integrated from 10 sources (see all 96):
    (articles sorted by number of sources associating them with KCNN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1). (PubMed id 10516439)1, 2, 3, 9 Litt M.... Adelman J.P. (Cytogenet. Cell Genet. 1999)
    2. Small-conductance, calcium-activated potassium channels from mammalian brain. (PubMed id 8781233)1, 2, 3 Koehler M.... Adelman J.P. (Science 1996)
    3. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (PubMed id 16382103)1, 3 Wei A.D....Wulff H. (Pharmacol. Rev. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Calmodulin binding to the C-terminus of the small-conductance Ca2+-activated K+ channel hSK1 is affected by alternative splicing. (PubMed id 11258935)1, 9 Zhang B.M....Sullivan R. (Biochemistry 2001)
    6. The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. (PubMed id 10683185)1, 9 Shah M. and Haylett D.G. (Br. J. Pharmacol. 2000)
    7. Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain. (PubMed id 11146124)1, 9 Rimini R....Terstappen G.C. (Brain Res. Mol. Brain Res. 2000)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Decreased expression of small-conductance Ca2+-activated K+ channels SK1 and SK2 in human chronic atrial fibrillation. (PubMed id 22154908)1 Yu T....Lin Q. (Life Sci. 2012)
    10. A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3780 HGNC: 6290 AceView: KCNN1 Ensembl:ENSG00000105642 euGenes: HUgn3780
    ECgene: KCNN1 Kegg: 3780 H-InvDB: KCNN1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KCNN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KCNN1 gene:
    Search GeneIP for patents involving KCNN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    About This Section

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