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KCNN1 Gene(Protein Coding)

Potassium Calcium-Activated Channel Subfamily N Member 1

GCID:
GC19P019014
GIFtS:
52
Genes Participants
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Aliases for KCNN1 Gene

Aliases for KCNN1 Gene

  • Potassium Calcium-Activated Channel Subfamily N Member 1 2 3 5
  • Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 1 2 3
  • Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 1 2 3
  • Small Conductance Calcium-Activated Potassium Channel 1 2 3
  • KCa2.1 3 4
  • SKCA1 3 4
  • SK1 3 4
  • Small Conductance Calcium-Activated Potassium Channel Protein 1 3
  • SKCa 1 4
  • Hsk1 3
  • SK 4

External Ids for KCNN1 Gene

Previous GeneCards Identifiers for KCNN1 Gene

  • GC19P018555
  • GC19P018454
  • GC19P017907
  • GC19P017924
  • GC19P017925
  • GC19P017926
  • GC19P018062
  • GC19P017627
  • GC19P017978
  • GC19P018179
  • GC19P018299
  • GC19P018331
  • GC19P018705

Summaries for KCNN1 Gene

Entrez Gene Summary for KCNN1 Gene

  • Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNN1 Gene

KCNN1 (Potassium Calcium-Activated Channel Subfamily N Member 1) is a Protein Coding gene. Among its related pathways are Insulin secretion and Transmission across Chemical Synapses. GO annotations related to this gene include protein heterodimerization activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNN2.

UniProtKB/Swiss-Prot for KCNN1 Gene

  • Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).

Tocris Summary for KCNN1 Gene

  • Calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).

Gene Wiki entry for KCNN1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNN1 Gene

Genomics for KCNN1 Gene

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  1. Regulatory Element

Regulatory Elements for KCNN1 Gene

Enhancers for KCNN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G018372 2.1 FANTOM5 Ensembl ENCODE dbSUPER 5 +429.8 429808 18.0 MLX CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 ENSG00000268030 COLGALT1 UPF1 ENSG00000268938 MVB12A ENSG00000269191 KXD1 IFI30 GDF15 PGLS
GH19G018392 1.7 FANTOM5 Ensembl ENCODE 5.2 +444.7 444654 7.9 FOXA2 ARNT MLX ARID4B ZNF48 YY1 ZNF121 GLIS2 GATA2 FOS IFI30 LRRC25 KIAA1683 LSM4 PGPEP1 GDF15 ELL SSBP4 KCNN1 ARRDC2
GH19G017946 1.6 FANTOM5 Ensembl ENCODE 5 -3.0 -2993 2.7 HDGF PKNOX1 AGO1 SIN3A ARID4B ZNF2 ZBTB7B ZNF766 ZNF143 SP3 CCDC124 KCNN1 UNC13A
GH19G018368 1.5 Ensembl ENCODE dbSUPER 4.9 +417.8 417847 2.2 HDGF MLX ARID4B DMAP1 YY1 SLC30A9 DEK ZNF263 PAF1 SP5 GDF15 KCNN1 PGPEP1
GH19G018289 2.1 FANTOM5 Ensembl ENCODE dbSUPER 2.6 +340.9 340944 6.1 CREB3L1 AGO1 ZFP64 YBX1 DMAP1 YY1 ZNF143 ZNF548 SP3 TBX21 ENSG00000268030 UPF1 ENSG00000268938 ENSG00000269439 MVB12A KIAA1683 JUND COLGALT1 ENSG00000269191 ENSG00000269815
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCNN1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the KCNN1 gene promoter:

Genomic Location for KCNN1 Gene

Chromosome:
19
Start:
17,951,293 bp from pter
End:
18,000,080 bp from pter
Size:
48,788 bases
Orientation:
Plus strand

Genomic View for KCNN1 Gene

Genes around KCNN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNN1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for KCNN1 Gene

Proteins for KCNN1 Gene

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  1. Antibody
  2. Protein
  3. Assay

  • Protein details for KCNN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92952-KCNN1_HUMAN
    Recommended name:
    Small conductance calcium-activated potassium channel protein 1
    Protein Accession:
    Q92952
    Secondary Accessions:
    • Q5KR10
    • Q6DJU4

    Protein attributes for KCNN1 Gene

    Size:
    543 amino acids
    Molecular mass:
    59987 Da
    Quaternary structure:
    • Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).

    Alternative splice isoforms for KCNN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNN1 Gene

Protein Expression for KCNN1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for KCNN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNN1 Gene

Domains & Families for KCNN1 Gene

Gene Families for KCNN1 Gene

HGNC:
IUPHAR :

Protein Domains for KCNN1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KCNN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92952

UniProtKB/Swiss-Prot:

KCNN1_HUMAN :
  • Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily.
Family:
  • Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily.
genes like me logo Genes that share domains with KCNN1: view

Function for KCNN1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  6. Cell Line
  7. Flow Cytometry

Molecular function for KCNN1 Gene

GENATLAS Biochemistry:
potassium intermediate/small conductance calcium-activated channel,subfamily N member 1,regulating neuronal excitabability
UniProtKB/Swiss-Prot Function:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).

Gene Ontology (GO) - Molecular Function for KCNN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005516 calmodulin binding IBA --
GO:0015269 calcium-activated potassium channel activity IEA,TAS 8781233
GO:0016286 small conductance calcium-activated potassium channel activity IEA,IBA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with KCNN1: view
genes like me logo Genes that share phenotypes with KCNN1: view

Animal Models for KCNN1 Gene

MGI Knock Outs for KCNN1:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNN1

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNN1 Gene

Localization for KCNN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNN1 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for KCNN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex TAS 8781233
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043025 neuronal cell body IBA,IEA --
genes like me logo Genes that share ontologies with KCNN1: view

No data available for Subcellular locations from COMPARTMENTS for KCNN1 Gene

Pathways & Interactions for KCNN1 Gene

genes like me logo Genes that share pathways with KCNN1: view

Pathways by source for KCNN1 Gene

1 KEGG pathway for KCNN1 Gene

Interacting Proteins for KCNN1 Gene

Selected Interacting proteins: Q92952-KCNN1_HUMAN for KCNN1 Gene via IID

Gene Ontology (GO) - Biological Process for KCNN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport TAS,IEA 8781233
GO:0007268 chemical synaptic transmission TAS 8781233
GO:0071805 potassium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNN1: view

No data available for SIGNOR curated interactions for KCNN1 Gene

Drugs & Compounds for KCNN1 Gene

Products:

  1. Drug

(31) Drugs for KCNN1 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Miconazole Approved, Investigational, Vet_approved Pharma Antagonist, Pore Blocker, Target, inhibitor 3706
Procaine Approved, Investigational, Vet_approved Pharma Channel blocker, Target, binder 49
Dequalinium Approved Pharma 2
Tubocurarine Approved Pharma antagonist 0
Bicuculline Experimental Pharma Antagonist 0

(4) Additional Compounds for KCNN1 Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+)-tubocurarine
Antagonist, Pore Blocker
TRAM 34
289905-88-0

(5) Tocris Compounds for KCNN1 Gene

Compound Action Cas Number
Apamin KCa2 channel blocker (small conductance) 24345-16-2
CyPPA Activator of KCa2.2 and KCa2.3 channels 73029-73-9
Iberiotoxin KCa channel blocker (big conductance) 129203-60-7
Paxilline SERCA ATPase blocker. Also potent BKCa channel blocker 57186-25-1
TRAM 34 Potent and highly selective KCa3.1 channel blocker 289905-88-0

(1) ApexBio Compounds for KCNN1 Gene

Compound Action Cas Number
LOE 908 hydrochloride 143482-60-4
genes like me logo Genes that share compounds with KCNN1: view

Transcripts for KCNN1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for KCNN1 Gene

(6) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNN1 Gene

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNN1 Gene

No ASD Table

Relevant External Links for KCNN1 Gene

GeneLoc Exon Structure for
KCNN1
ECgene alternative splicing isoforms for
KCNN1

Expression for KCNN1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNN1 Gene

mRNA expression in normal human tissues for KCNN1 Gene
mRNA expression by BioGPS for KCNN1 Gene

Protein differential expression in normal tissues from HIPED for KCNN1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNN1 Gene



Protein tissue co-expression partners for KCNN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCNN1 Gene:

KCNN1

SOURCE GeneReport for Unigene cluster for KCNN1 Gene:

Hs.158173
genes like me logo Genes that share expression patterns with KCNN1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNN1 Gene

Orthologs for KCNN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia KCNN1 34 35
  • 99.69 (n)
dog
(Canis familiaris)
 Mammalia KCNN1 34 35
  • 89.87 (n)
cow
(Bos Taurus)
 Mammalia KCNN1 34 35
  • 89.44 (n)
rat
(Rattus norvegicus)
 Mammalia Kcnn1 34
  • 82.21 (n)
mouse
(Mus musculus)
 Mammalia Kcnn1 34 16 35
  • 81.91 (n)
oppossum
(Monodelphis domestica)
 Mammalia KCNN1 35
  • 67 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia KCNN1 35
  • 57 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii kcnn1b 35
  • 48 (a)
 OneToMany
kcnn1a 35
  • 44 (a)
 OneToMany
Dr.14710 34
fruit fly
(Drosophila melanogaster)
 Insecta SK 36 35
  • 62 (a)
worm
(Caenorhabditis elegans)
 Secernentea C03F11.1 36
  • 35 (a)
kcnl-2 35
  • 30 (a)
 ManyToMany
C53A5.5 36
  • 29 (a)
kcnl-4 35
  • 26 (a)
 ManyToMany
kcnl-1 35
  • 23 (a)
 ManyToMany
kcnl-3 35
  • 22 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 59 (a)
 OneToMany
Species where no ortholog for KCNN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KCNN1 Gene

ENSEMBL:
Gene Tree for KCNN1 (if available)
TreeFam:
Gene Tree for KCNN1 (if available)

Paralogs for KCNN1 Gene

Paralogs for KCNN1 Gene

(4) SIMAP similar genes for KCNN1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCNN1: view

Variants for KCNN1 Gene

Sequence variations from dbSNP and Humsavar for KCNN1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000006098 -- 17,958,447(+) CACTC(C/T)AAACT intron-variant
rs1000174189 -- 17,998,645(+) CCCCC(C/G)GTGGG downstream-variant-500B, utr-variant-3-prime
rs1000205292 -- 17,961,334(+) CACTT(C/T)GGGAG intron-variant
rs1000243075 -- 17,950,747(+) GGGTC(G/T)CAGCC upstream-variant-2KB
rs1000248418 -- 17,973,408(+) CCCAC(A/G)CAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNN1 Gene

Variant ID Type Subtype PubMed ID
esv3367177 CNV insertion 20981092
esv3556127 CNV deletion 23714750
esv3643828 CNV gain 21293372
esv3643829 CNV gain 21293372
esv991938 CNV gain 20482838
nsv1071515 CNV deletion 25765185
nsv2428 CNV insertion 18451855
nsv470130 CNV loss 18288195
nsv833772 CNV gain+loss 17160897

Variation tolerance for KCNN1 Gene

Gene Damage Index Score: 1.20; 24.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNN1 Gene

Disorders for KCNN1 Gene

Relevant External Links for KCNN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNN1

No disorders were found for KCNN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNN1 Gene

Publications for KCNN1 Gene

  1. Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1). (PMID: 10516439) Litt M. … Adelman J.P. (Cytogenet. Cell Genet. 1999) 2 3 4 22 64
  2. Small-conductance, calcium-activated potassium channels from mammalian brain. (PMID: 8781233) Koehler M. … Adelman J.P. (Science 1996) 2 3 4 64
  3. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (PMID: 16382103) Wei A.D. … Wulff H. (Pharmacol. Rev. 2005) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Calmodulin binding to the C-terminus of the small-conductance Ca2+-activated K+ channel hSK1 is affected by alternative splicing. (PMID: 11258935) Zhang B.M. … Sullivan R. (Biochemistry 2001) 3 22 64

Products for KCNN1 Gene

Sources for KCNN1 Gene

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