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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KCNN1 Gene

protein-coding GIFtS: 55
GCID: GC19P018062

potassium intermediate/small conductance calcium-activated...

Explore 20 diseases affiliated with
KCNN1 via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 1¹ ²		Small Conductance Calcium-Activated Potassium Channel Protein 1²
KCa2.1¹ ² ³		SK³
HSK1¹		SKCa1³
SK1² ³		SKCa 1³
SKCA1²

External Ids:	HGNC: 6290¹	Entrez Gene: 3780²	Ensembl: ENSG00000105642⁷	OMIM: 602982⁵	UniProtKB: Q92952³

Export aliases for KCNN1 gene to outside databases

Previous GC identifers: GC19P018555 GC19P018454 GC19P017907 GC19P017924 GC19P017925 GC19P017926 GC19P017627

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNN1:

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several

seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is

kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this

gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing

to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a

voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of

the KCNN family of potassium channel genes. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCNN1_HUMAN, Q92952

Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by

membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of

synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity)

summary for KCNN1:

Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+

ions across biological membranes. They are broadly classified into three subtypes, SK, IK and BK channels,

based on their conductance (small, intermediate and big conductance respectively). The small conductance KCa

channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance

KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both

play important roles in many processes involving Ca2+-dependent signalling in both electrically excitable

and non-excitable cells. The BK family of KCa channels (also known as Slo or Maxi-K channels) are also

voltage-sensitive and include KCa1.1 (Slo1), KCa4.1 (Slo2.2), KCa4.2 (Slo2.1) and KCa5.1 (Slo3). These

channels do not require calmodulin for activation as they contain three direct bivalent cation binding

sites.

Gene Wiki entry for KCNN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KCNN1 gene promoter:
ER-alpha GR GR-beta MIF-1 AP-4 Egr-4 c-Rel STAT3 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNN1 promoter sequence

Search SABiosciences Chromatin IP Primers for KCNN1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNN1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.1

KCNN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNN1 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P018062: view genomic region (about GC identifiers)

Start:	18,062,111 bp from pter	End:	18,110,893 bp from pter
Size:	48,783 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KCNN1_HUMAN, Q92952 (See protein sequence)

Recommended Name: Small conductance calcium-activated potassium channel protein 1

Size: 543 amino acids; 59987 Da

Subunit: Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit

which regulates the channel activity through calcium-binding (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: Q5KR10 Q6DJU4

Alternative splicing: 2 isoforms: Q92952-1 Q92952-2

Explore the universe of human proteins at neXtProt for KCNN1: NX_Q92952

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92952

KCNN1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002239.2

ENSEMBL proteins:

ENSP00000222249 ENSP00000437873

Reactome Protein details: Q92952
Human Recombinant Protein Products for KCNN1:

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	Uscn Proteins for KCNN1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005886	plasma membrane	TAS	--
GO:0008076	voltage-gated potassium channel complex	TAS	8781233
GO:0016021	integral to membrane	--	--

KCNN1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for KCNN1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KCNN1 for domains About GeneDecksing

3 InterPro domains/families:

IPR004178 CaM-bd_dom

IPR015449 K_chnl_Ca-activ_SK

IPR013099 Ion_trans_2

Graphical View of Domain Structure for InterPro Entry Q92952

ProtoNet protein and cluster: Q92952

3 Blocks protein families:

IPB004178 Calmodulin binding domain

IPB011996 SK channel region

IPB013099 Ion transport 2

UniProtKB/Swiss-Prot: KCNN1_HUMAN, Q92952

Similarity: Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: KCNN1_HUMAN, Q92952

Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by

membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of

synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity)

Genatlas biochemistry entry for KCNN1:

potassium intermediate/small conductance calcium-activated channel,subfamily N member 1,regulating neuronal

excitabability

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005516	calmodulin binding	IEA	--
GO:0015269	calcium-activated potassium channel activity	TAS	8781233
GO:0016286	small conductance calcium-activated potassium channel activity	IEA	--

KCNN1 for ontologies About GeneDecksing

Phenotypes:
2 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Kcnn1):

nervous system

no phenotypic analysis

KCNN1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Kcnn1^tm1.1Jpad for KCNN1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for KCNN1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNN1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Potassium Channels

Potassium Channels

1.00

Potassium transporters: outward current

0.42

Ca2+ activated K+ channels

Ca2+ activated K+ channels

1.00

Synaptic transmission: ion currents

Synaptic transmission: ion currents

1.00

Transmission across Chemical Synapses

Neuronal System

0.67

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for KCNN1

	Synaptic transmission- ion currents
	Potassium transporters- outward current

3 Reactome Pathways for KCNN1

	Potassium Channels
	Ca2+ activated K+ channels
	Neuronal System

KCNN1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KCNN1

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5 Interacting proteins for KCNN1 (Q92952³ ENSP00000222249⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
GRB2	P62993³, ENSP00000339007⁴	I2D: score=1 STRING: ENSP00000339007
MAPK3	P27361³	I2D: score=1
KCNN2	ENSP00000264773⁴	STRING: ENSP00000264773
KCNN3	ENSP00000271915⁴	STRING: ENSP00000271915

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006813	potassium ion transport	TAS	8781233
GO:0007268	synaptic transmission	TAS	--

KCNN1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KCNN1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for KCNN1 available from Tocris Bioscience About this table

Compound	Action	CAS #
UCL 1684	Highly potent blocker of SKCa	[199934-16-2]
GW 542573X	Selective activator of SK1 channels	[660846-41-3]
Apamin	K+ channel blocker (small conductance, Ca2+-dependent)	[24345-16-2]
4-Aminopyridine	Non-selective KV channel blocker	[504-24-5]

1 HMDB Compound for KCNN1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 DrugBank Compound for KCNN1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Miconazole	--	22916-47-8	target	inhibitor	8760033 1376313

10/17 Novoseek chemical compound relationships for KCNN1 gene (see all 17) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
apamin	88.9	18	17142458 (3), 10696100 (2), 10725258 (1), 11223279 (1) (see all 13)
dequalinium chloride	81.1	1	10696100 (1)
scyllatoxin	77.4	1	10696100 (1)
potassium	76.6	62	10732800 (2), 9774106 (2), 15379997 (2), 12875918 (2) (see all 49)
sphingosine	74.4	17	20156522 (2), 16522638 (2), 17898040 (1), 16926156 (1) (see all 12)
charybdotoxin	72.1	2	10725258 (1), 9843105 (1)
iberiotoxin	65.1	1	10725258 (1)
d-tubocurarine	65.1	1	10696100 (1)
clotrimazole	65.1	1	10519135 (1)
calcium	40.9	27	10204997 (3), 9774106 (2), 15379997 (2), 9326665 (2) (see all 16)

Search CenterWatch for drugs/clinical trials and news about KCNN1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KCNN1 gene:

NM_002248.4

Unigene Cluster for KCNN1:

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1

Hs.158173 [show with all ESTs]

Unigene Representative Sequence: NM_002248

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000222249(uc002nht.3 uc010xqa.1) ENST00000536713

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Additional cDNA sequence:

AB198191.1 AK298170.1 BC075037.2 U69883.2

3 DOTS entries:

DT.438112 DT.121438614 DT.97777878

24/27 AceView cDNA sequences (see all 27):

NM_002248 BX106650 BI522613 F11363 U69883 AA594089 BM718136 AA351095

AI937237 BC075037 AA325431 F09023 AA350009 BM930603 BF062198 BX393926

D61063 AW594619 BE504989 BU153891 C15510 AI825516 D60120 D60321

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCNN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

KCNN1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Renal Vesicle

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KCNN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNN1

SOURCE GeneReport for Unigene cluster: Hs.158173

SABiosciences Expression via Pathway-Focused PCR Arrays including KCNN1:

Neuronal Ion Channels in human mouse rat

MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KCNN1 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Kcnn1^{1 , 5}	potassium intermediate/small conductance calcium-activated more^{1, 5}	82.47(n)¹ 84.2(a)¹		8 (34.27 cM)⁵ 84036¹ NM_032397.2¹ NP_115773.2¹ 70842049⁵
zebrafish (Danio rerio)	Actinopterygii	Dr.14710²	Transcribed sequence with moderate similarity to protein more	80.85(n)		BM082635.1

ENSEMBL Gene Tree for KCNN1 (if available)
TreeFam Gene Tree for KCNN1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KCNN1 gene

KCNN4² KCNN2² KCNN3²

5 SIMAP similar genes for KCNN1 using alignment to 1 protein entry: KCNN1_HUMAN:

KCNN3 SK3 SK2 KCNN2 KCNN4

KCNN1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147262719^1,2		--	18060334(+)	`CTCATC/TCCATG`	1	--	us2k¹		0	--	--	--	--
rs139673825^1,2		--	18060346(+)	`GGACAC/TATACC`	1	--	us2k¹		0	--	--	--	--
rs143580018^1,2		--	18060361(+)	`CTGGGC/TCTTTG`	1	--	us2k¹		0	--	--	--	--
rs6512238^1,2	C,F,A,H	--	18060457(+)	`AAACAA/CAATCA`	1	--	us2k¹		24		NS EA NA WA CSA	2353
rs11672874^1,2	C,A,H	--	18060482(+)	`CAGCCC/TCCCAG`	1	--	us2k¹		5		NA WA	244
rs144191783^1,2		--	18060650(+)	`TTTTCC/TCCAGG`	1	--	us2k¹		0	--	--	--	--
rs186081748^1,2		--	18061071(+)	`AGAGCA/CCTGTG`	1	--	us2k¹		0	--	--	--	--
rs148687631^1,2		--	18061164(+)	`TAGGGA/GGAGAA`	1	--	us2k¹		0	--	--	--	--
rs73526376^1,2	C	--	18061263(+)	`TCGGCC/TTGTGA`	1	--	us2k¹		2		WA	120
rs7250332^1,2	C,F,A,H	--	18061509(+)	`GTCACC/TTCTGC`	1	--	us2k¹		32		EA NA NS WA CSA	2988

HapMap Linkage Disequilibrium report for KCNN1 (18062111 - 18110893 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KCNN1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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KCNN1 for disorders           About GeneDecksing

OMIM gene information: 602982    OMIM disorders: --

20 diseases for KCNN1:    About MalaCards

myotonic dystrophy type 1 traumatic brain injury myotonic dystrophy bipolar affective disorder

brain injury neuronitis fanconi's anemia muscular dystrophy

migraine bipolar disorder parkinson's disease anemia

alzheimer's disease schizophrenia ischemia ataxia

retinitis tuberculosis melanoma mycobacterium tuberculosis

2 Novoseek disease relationships for KCNN1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia	29.9	4	10732800 (1), 10395217 (1), 10196711 (1)
glioma	0	1	8051694 (1)

Export disorders for KCNN1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KCNN1 gene, integrated from 9 sources (see all 93):
(articles sorted by number of sources associating them with KCNN1)

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Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1). (PubMed id 10516439)^{1, 2, 3, 9} Litt M.... Adelman J.P. (1999)
Small-conductance, calcium-activated potassium channels from mammalian brain. (PubMed id 8781233)^{1, 2, 3} Koehler M.... Adelman J.P. (1996)
International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (PubMed id 16382103)^{1, 3} Wei A.D....Wulff H. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Calmodulin binding to the C-terminus of the small-conductance Ca2+-activated K+ channel hSK1 is affected by alternative splicing. (PubMed id 11258935)^{1, 9} Zhang B.M....Sullivan R. (2001)
The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. (PubMed id 10683185)^{1, 9} Shah M. and Haylett D.G. (2000)
Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain. (PubMed id 11146124)^{1, 9} Rimini R....Terstappen G.C. (2000)
Decreased expression of small-conductance Ca2+-activat ed K+ channels SK1 and SK2 in human chronic atrial fibrillation. (PubMed id 22154908)¹ Yu T....Lin Q. (2012)
TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)¹ Vanderwerf S.M....Bagby G.C. (2009)
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)¹ Wu C....Li S.S. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3780	HGNC: 6290	AceView: KCNN1	Ensembl:ENSG00000105642	euGenes: HUgn3780
ECgene: KCNN1	H-InvDB: KCNN1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KCNN1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KCNN1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KCNN1 gene:
Search GeneIP for patents involving KCNN1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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