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Aliases for KCNN1 Gene

Aliases for KCNN1 Gene

  • Potassium Calcium-Activated Channel Subfamily N Member 1 2 3
  • Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 1 2 3 5
  • Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 1 2 3
  • Small Conductance Calcium-Activated Potassium Channel 1 2 3
  • KCa2.1 3 4
  • SKCA1 3 4
  • SK1 3 4
  • SKCa 1 4
  • Hsk1 3
  • SK 4

External Ids for KCNN1 Gene

Previous GeneCards Identifiers for KCNN1 Gene

  • GC19P018555
  • GC19P018454
  • GC19P017907
  • GC19P017924
  • GC19P017925
  • GC19P017926
  • GC19P018062
  • GC19P017627
  • GC19P017978
  • GC19P018179

Summaries for KCNN1 Gene

Entrez Gene Summary for KCNN1 Gene

  • Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNN1 Gene

KCNN1 (Potassium Calcium-Activated Channel Subfamily N Member 1) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Insulin secretion. GO annotations related to this gene include protein heterodimerization activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNN4.

UniProtKB/Swiss-Prot for KCNN1 Gene

  • Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).

Tocris Summary for KCNN1 Gene

  • Calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).

Gene Wiki entry for KCNN1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNN1 Gene

Genomics for KCNN1 Gene

Regulatory Elements for KCNN1 Gene

Genomic Location for KCNN1 Gene

Chromosome:
19
Start:
17,951,293 bp from pter
End:
18,000,080 bp from pter
Size:
48,788 bases
Orientation:
Plus strand

Genomic View for KCNN1 Gene

Genes around KCNN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNN1 Gene

Proteins for KCNN1 Gene

  • Protein details for KCNN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92952-KCNN1_HUMAN
    Recommended name:
    Small conductance calcium-activated potassium channel protein 1
    Protein Accession:
    Q92952
    Secondary Accessions:
    • Q5KR10
    • Q6DJU4

    Protein attributes for KCNN1 Gene

    Size:
    543 amino acids
    Molecular mass:
    59987 Da
    Quaternary structure:
    • Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).

    Alternative splice isoforms for KCNN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNN1 Gene

Proteomics data for KCNN1 Gene at MOPED

Post-translational modifications for KCNN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNN1 Gene

Domains & Families for KCNN1 Gene

Gene Families for KCNN1 Gene

Suggested Antigen Peptide Sequences for KCNN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92952

UniProtKB/Swiss-Prot:

KCNN1_HUMAN :
  • Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily.
Family:
  • Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily.
genes like me logo Genes that share domains with KCNN1: view

Function for KCNN1 Gene

Molecular function for KCNN1 Gene

GENATLAS Biochemistry:
potassium intermediate/small conductance calcium-activated channel,subfamily N member 1,regulating neuronal excitabability
UniProtKB/Swiss-Prot Function:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).
genes like me logo Genes that share phenotypes with KCNN1: view

Animal Models for KCNN1 Gene

MGI Knock Outs for KCNN1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNN1 Gene

Localization for KCNN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNN1 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for KCNN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with KCNN1: view

No data available for Subcellular locations from COMPARTMENTS for KCNN1 Gene

Pathways & Interactions for KCNN1 Gene

genes like me logo Genes that share pathways with KCNN1: view

Pathways by source for KCNN1 Gene

1 KEGG pathway for KCNN1 Gene

Interacting Proteins for KCNN1 Gene

Selected Interacting proteins: Q92952-KCNN1_HUMAN for KCNN1 Gene via I2D

Gene Ontology (GO) - Biological Process for KCNN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport IEA,TAS 8781233
genes like me logo Genes that share ontologies with KCNN1: view

No data available for SIGNOR curated interactions for KCNN1 Gene

Drugs & Compounds for KCNN1 Gene

(28) Drugs for KCNN1 Gene - From: IUPHAR, DGIdb, Novoseek, Tocris, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Miconazole Approved, Investigational Pharma Antagonist, Pore Blocker, Target, inhibitor 3026
Procaine Approved, Investigational Pharma Channel blocker, Target, binder 35
Tubocurarine Approved Pharma antagonist 0
apamin Pharma Antagonist, Pore Blocker 0
bicuculline Pharma Antagonist 0

(8) Additional Compounds for KCNN1 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+)-tubocurarine
Antagonist, Pore Blocker
1-EBIO
10045-45-1
BMS 191011
202821-81-6
DCEBIO
60563-36-2
SKA 31
40172-65-4
genes like me logo Genes that share compounds with KCNN1: view

Transcripts for KCNN1 Gene

Unigene Clusters for KCNN1 Gene

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNN1 Gene

No ASD Table

Relevant External Links for KCNN1 Gene

GeneLoc Exon Structure for
KCNN1
ECgene alternative splicing isoforms for
KCNN1

Expression for KCNN1 Gene

mRNA expression in normal human tissues for KCNN1 Gene

Protein differential expression in normal tissues from HIPED for KCNN1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNN1 Gene



SOURCE GeneReport for Unigene cluster for KCNN1 Gene Hs.158173

genes like me logo Genes that share expression patterns with KCNN1: view

Protein tissue co-expression partners for KCNN1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KCNN1 Gene

Orthologs for KCNN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNN1 35
  • 99.69 (n)
  • 100 (a)
KCNN1 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNN1 35
  • 89.44 (n)
  • 92.45 (a)
KCNN1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNN1 36
  • 94 (a)
OneToOne
KCNN1 35
  • 89.87 (n)
  • 93.92 (a)
mouse
(Mus musculus)
Mammalia Kcnn1 36
  • 82 (a)
OneToOne
Kcnn1 16
Kcnn1 35
  • 81.91 (n)
  • 83.64 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNN1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNN1 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnn1 35
  • 82.21 (n)
  • 83.77 (a)
zebrafish
(Danio rerio)
Actinopterygii kcnn1a 36
  • 44 (a)
OneToMany
kcnn1b 36
  • 48 (a)
OneToMany
Dr.14710 35
fruit fly
(Drosophila melanogaster)
Insecta SK 37
  • 62 (a)
SK 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kcnl-1 36
  • 23 (a)
ManyToMany
kcnl-2 36
  • 30 (a)
ManyToMany
kcnl-3 36
  • 22 (a)
ManyToMany
kcnl-4 36
  • 26 (a)
ManyToMany
C03F11.1 37
  • 35 (a)
C53A5.5 37
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
OneToMany
Species with no ortholog for KCNN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KCNN1 Gene

ENSEMBL:
Gene Tree for KCNN1 (if available)
TreeFam:
Gene Tree for KCNN1 (if available)

Paralogs for KCNN1 Gene

Paralogs for KCNN1 Gene

(4) SIMAP similar genes for KCNN1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCNN1: view

Variants for KCNN1 Gene

Sequence variations from dbSNP and Humsavar for KCNN1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2278991 -- 17,984,951(+) GAGAA(A/G)GTTCT intron-variant
rs2278992 -- 17,984,960(+) CTTCC(C/T)GGTGT intron-variant
rs2384846 -- 17,970,128(+) TAGGT(C/T)TCATA intron-variant
rs3746192 -- 17,974,619(-) CTCTC(A/G)GAAGG intron-variant
rs3746193 -- 17,974,209(-) TAGTC(A/G)CTGAG nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for KCNN1 Gene

Variant ID Type Subtype PubMed ID
nsv911214 CNV Loss 21882294
nsv833772 CNV Gain+Loss 17160897
nsv911226 CNV Loss 21882294
nsv911227 CNV Loss 21882294
dgv3767n71 CNV Loss 21882294
nsv470130 CNV Loss 18288195
dgv3768n71 CNV Loss 21882294
dgv3769n71 CNV Loss 21882294
nsv911233 CNV Loss 21882294
esv274435 CNV Insertion 20981092
esv991938 CNV Gain 20482838
nsv2428 CNV Insertion 18451855

Variation tolerance for KCNN1 Gene

Gene Damage Index Score: 1.20; 24.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNN1 Gene

HapMap Linkage Disequilibrium report
KCNN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNN1 Gene

Disorders for KCNN1 Gene

Relevant External Links for KCNN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNN1

No disorders were found for KCNN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNN1 Gene

Publications for KCNN1 Gene

  1. Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1). (PMID: 10516439) Litt M. … Adelman J.P. (Cytogenet. Cell Genet. 1999) 2 3 4 23 67
  2. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (PMID: 16382103) Wei A.D. … Wulff H. (Pharmacol. Rev. 2005) 2 3
  3. Calmodulin binding to the C-terminus of the small-conductance Ca2+-activated K+ channel hSK1 is affected by alternative splicing. (PMID: 11258935) Zhang B.M. … Sullivan R. (Biochemistry 2001) 3 23
  4. The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. (PMID: 10683185) Shah M. … Haylett D.G. (Br. J. Pharmacol. 2000) 3 23
  5. Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain. (PMID: 11146124) Rimini R. … Terstappen G.C. (Brain Res. Mol. Brain Res. 2000) 3 23

Products for KCNN1 Gene

Sources for KCNN1 Gene

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