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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNMB4 Gene

protein-coding   GIFtS: 55
GCID: GC12P070760

potassium large conductance calcium-activated channel, subfamily...
 Explore 6 diseases affiliated with
KCNMB4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCNMB4    

Aliases
for KCNMB4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Potassium Large Conductance Calcium-Activated Channel, Subfamily M, Beta
Member 41 2
     Hbeta43
Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-42 3     K(VCA)Beta-41
Charybdotoxin Receptor Subunit Beta-42 3     Large Conductance Calcium-Dependent Potassium Ion Channel Beta 4 Subunit2
Maxi K Channel Subunit Beta-42 3     Slo-Beta-41
BKbeta42 3     Hbeta43
BK Channel Subunit Beta-42 3     K(VCA)Beta-41
Calcium-Activated Potassium Channel Subunit Beta-42     Slo-Beta-41

External Ids:    HGNC: 62891   Entrez Gene: 273452   Ensembl: ENSG000001356437   OMIM: 6052235   UniProtKB: Q86W473   

Export aliases for KCNMB4 gene to outside databases

Previous GC identifers: GC12P070632 GC12P070476 GC12P069046 GC12P067810


Summaries
for KCNMB4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KCNMB4:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the
control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming
alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which
slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to
more negative potentials than does the beta 1 subunit. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCMB4_HUMAN, Q86W47
Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium
sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating
kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1
channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes
KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations

summary for KCNMB4:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNMB4


Genomic Views
for KCNMB4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNMB4 gene promoter:
         E2F-4   E2F-3a   E2F-5   MyoD   E2F-2   FOXL1   E2F   E2F-1   HFH-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNMB4 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNMB4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNMB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q15

KCNMB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNMB4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P070760:  view genomic region     (about GC identifiers)

Start:
 70,760,056 bp from pter      End:
 70,828,072 bp from pter
Size:
 68,017 bases      Orientation:
 plus strand

Proteins
for KCNMB4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCMB4_HUMAN, Q86W47 (See protein sequence)
Recommended Name: Calcium-activated potassium channel subunit beta-4  
Size: 210 amino acids; 23949 Da
Subunit: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB4 per KCNMA1 tetramer
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Treatment with okadaic acid reduces its effect on KCNMA1
Secondary accessions: Q8IVR3 Q9NPA4 Q9P0G5

Explore the universe of human proteins at neXtProt for KCNMB4: NX_Q86W47

Post-translational modifications:

  • Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics1
  • N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the
    • interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86W47

    • KCNMB4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055320.4  
    ENSEMBL proteins: 
     ENSP00000258111   ENSP00000431137  
    Reactome Protein details: Q86W47
    Human Recombinant Protein Products: 
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    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA10692449
    GO:0008076voltage-gated potassium channel complex IDA10692449


    KCNMB4 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for KCNMB4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCNMB4 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003930 K_chnl_Ca-activ_BK_bsu

    Graphical View of Domain Structure for InterPro Entry Q86W47

    ProtoNet protein and cluster: Q86W47

    1 Blocks protein family: IPB003930 Calcium-activated BK potassium channel beta subunit signature

    UniProtKB/Swiss-Prot: KCMB4_HUMAN, Q86W47
    Domain: Resistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain
    Similarity: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB4 subfamily


    Function
    for KCNMB4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCMB4_HUMAN, Q86W47
    Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium
    sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating
    kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1
    channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes
    KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10692449
    GO:0015269calcium-activated potassium channel activity IDA10692449


    KCNMB4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for KCNMB4:
     High actin ratio cells 

    Animal Models:
         Mouse knock-outs for KCNMB4: Kcnmb4tm1Rwa Kcnmb4tm1Lex
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Kcnmb4):
     behavior/neurological  hearing/vestibular/ear  nervous system  normal 

    KCNMB4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KCNMB4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Nitric oxide stimulates guanylate cyclase
    		Nitric oxide stimulates guanylate cyclase1.00
    		Platelet homeostasis0.34
    		cGMP effects0.75
    2Potassium Channels
    		Potassium Channels1.00
    3Ca2+ activated K+ channels
    		Ca2+ activated K+ channels1.00
    4Synaptic transmission: ion currents
    		Synaptic transmission: ion currents1.00
    5Transmission across Chemical Synapses
    		Neuronal System0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for KCNMB4
        Synaptic transmission- ion currents


    5/7        Reactome Pathways for KCNMB4 (see all 7)
        Hemostasis
    Potassium Channels
    Ca2+ activated K+ channels
    cGMP effects
    Platelet homeostasis


    1         Kegg Pathway  (Kegg details for KCNMB4):
        Vascular smooth muscle contraction


    KCNMB4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNMB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for KCNMB4 (ENSP000002581114) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNMA1ENSP000002866274STRING: ENSP00000286627
    KCNMB1ENSP000002746294STRING: ENSP00000274629
    PRKG2ENSP000002643994STRING: ENSP00000264399
    PRKACAENSP000003095914STRING: ENSP00000309591
    PRKACBENSP000003597194STRING: ENSP00000359719
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001508regulation of action potential IDA10692449
    GO:0005513detection of calcium ion IDA10692449
    GO:0006813potassium ion transport IDA10692449
    GO:0007268synaptic transmission TAS--
    GO:0007596blood coagulation TAS--


    KCNMB4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCNMB4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNMB4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AM 92016 hydrochlorideKV channel blocker[178894-81-0]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    4-AminopyridineNon-selective KV channel blocker[504-24-5]

    1 HMDB Compound for KCNMB4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for KCNMB4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Miconazole-- 22916-47-8targetinhibitor8760033 1376313

    Search CenterWatch for drugs/clinical trials and news about KCNMB4 / KCMB4 

    Transcripts
    for KCNMB4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCNMB4 gene: 
    NM_014505.5  

    Unigene Cluster for KCNMB4:

    Potassium large conductance calcium-activated channel, subfamily M, beta member 4
    Hs.525529  [show with all ESTs]
    Unigene Representative Sequence: NM_014505
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258111(uc001svx.3) ENST00000531884

    miRNA
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    hsa-miR-562 hsa-miR-550a hsa-miR-1539 hsa-miR-1976
    SwitchGear 3'UTR luciferase reporter plasmid: KCNMB4 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF160967.1 AF207992.1 AF215891.1 AK054684.1 BC037898.1 BC042446.2 BC047427.1 BC050621.1 

    3 DOTS entries:

    DT.455812  DT.100752407  DT.99979169 

    24/121 AceView cDNA sequences (see all 121):

    AF215891 AW574931 AA897143 CB054146 R44201 AA418442 R85016 AI431742 
    BI821301 BU556960 AW296103 Z40594 AI253037 AW009009 C20762 AI631530 
    AI797709 AI934993 AI674247 CR613566 Z44262 AI204969 AA280547 CR614941 

    GeneLoc Exon Structure


    Expression
    for KCNMB4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNMB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGAAGCGCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KCNMB4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerCholinergic Amacrine CellsAmacrine, Retina
    BrainMedulla OblongataBrain
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

    See KCNMB4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNMB4

    SOURCE GeneReport for Unigene cluster: Hs.525529

    UniProtKB/Swiss-Prot: KCMB4_HUMAN, Q86W47
    Tissue specificity: Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex,
    medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus
    callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues

        SABiosciences Expression via Pathway-Focused PCR Array including KCNMB4: 
              Neuronal Ion Channels in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for KCNMB4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for KCNMB4 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KCNMB41 potassium large conductance calcium-activated channel, more 72.7(n)
    66.19(a)    		   417852  NM_001199630.1  NP_001186559.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KCNMB46
    		 --
    		 82(a)
    		 1 ↔ 1
    		 GL343256.1(1954915-2005469)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.163112 Transcribed sequence with weak similarity to protein more 78.97(n)    142010670 


    ENSEMBL Gene Tree for KCNMB4 (if available)
    TreeFam Gene Tree for KCNMB4 (if available) 

    Paralogs
    for KCNMB4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNMB4 gene
    KCNMB22  KCNMB32  KCNMB12  
    2 SIMAP similar genes for KCNMB4 using alignment to 2 protein entries:     KCMB4_HUMAN (see all proteins):
    KCNMB3    KCNMB2

    KCNMB4 for paralogs           About GeneDecksing



    Genomic Variants
    for KCNMB4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1105 NCBI SNPs in KCNMB4 are shown (see all 1105)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1923399351,2
    		--70758219(+) GATCTC/TAGACA 1 -- us2k10--------
    rs773726881,2
    		C,F,--70758255(+) GATTAT/CAACAA 1 -- us2k11Minor allele frequency- C:0.11EA 120
    rs1445870281,2
    		--70758265(+) ATAGAA/GAAAAA 1 -- us2k10--------
    rs741040091,2
    		C,--70758271(+) AAAAAA/GGATTA 1 -- us2k12Minor allele frequency- G:0.09WA 120
    rs1167865181,2
    		C,F,--70758500(+) TGGACG/TTTTTT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1844992291,2
    		--70758547(+) CACTTA/GGGATC 1 -- us2k10--------
    rs1403852211,2
    		--70758639(+) TGCAGG/TCGAAA 1 -- us2k10--------
    rs1173978611,2
    		--70758641(+) CAGTCG/TAAAGG 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs123104171,2
    		F,--70758664(+) GTTAAG/ATAACA 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs1907842871,2
    		--70758704(+) TTCCAA/TGATTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNMB4 (70760056 - 70828072 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KCNMB4: --

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    Disorders / Diseases
    for KCNMB4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCNMB4 for disorders           About GeneDecksing

    OMIM gene information: 605223    OMIM disorders: --

    6 diseases for KCNMB4:    About MalaCards
    corpus callosum    neuronitis    epilepsy syndrome    seizures
    cerebritis    alcoholism

    Human Genome Epidemiology (HuGE) Navigator: KCNMB4 (1 document)

    Export disorders for KCNMB4 gene to outside databases

    Publications
    for KCNMB4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNMB4 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with KCNMB4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family. (PubMed id 10828459)1, 2, 3, 9 Behrens R....Pongs O. (2000)
    2. Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. (PubMed id 10692449)1, 2, 3 Brenner R.... Aldrich R.W. (2000)
    3. Phosphorylation-dependent functional coupling of hSlo calcium- dependent potassium channel and its hbeta 4 subunit. (PubMed id 11790768)1, 2, 9 Jin P.... Levitan I.B. (2002)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Reciprocal modulation between the alpha and beta 4 subunits of hSlo calcium-dependent potassium channels. (PubMed id 12223479)1, 2 Jin P.... Levitan I.B. (2002)
    6. New disguises for an old channel: MaxiK channel beta-subunits. (PubMed id 12136044)1, 2 Orio P.... Latorre R. (2002)
    7. A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels. (PubMed id 10804197)1, 2 Weiger T.M.... Curtis R. (2000)
    8. A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. (PubMed id 10792058)1, 2 Meera P.... Toro L. (2000)
    9. Modulation by the BK accessory I^4 subunit of phosphor ylation-dependent changes in excitability of dentate gyrus granule neurons. (PubMed id 21848922)1 Petrik D....Brenner R. (2011)
    10. Interactions between beta subunits of the KCNMB famil y and Slo3: beta4 selectively modulates Slo3 expression and function. (PubMed id 19578543)1 Yang C.T....Lingle C.J. (2009)

    External Searches for KCNMB4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing KCNMB4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27345 HGNC: 6289 AceView: KCNMB4 Ensembl:ENSG00000135643 euGenes: HUgn27345
    ECgene: KCNMB4 Kegg: 27345 H-InvDB: KCNMB4

    Other Databases showing KCNMB4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCNMB4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNMB4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCNMB4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCNMB4 gene:
    Search GeneIP for patents involving KCNMB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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