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Aliases for KCNMB4 Gene

Aliases for KCNMB4 Gene

  • Potassium Channel Subfamily M Regulatory Beta Subunit 4 2 3
  • Potassium Large Conductance Calcium-Activated Channel, Subfamily M, Beta Member 4 2 3
  • Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-4 3 4
  • Charybdotoxin Receptor Subunit Beta-4 3 4
  • Big Potassium Channel Beta Subunit 4 2 3
  • Maxi K Channel Subunit Beta-4 3 4
  • MaxiK Channel Beta-Subunit 4 2 3
  • BK Channel Beta Subunit 4 2 3
  • BK Channel Subunit Beta-4 3 4
  • K(VCA)Beta-4 3 4
  • Slo-Beta-4 3 4
  • BKbeta4 3 4
  • Hbeta4 3 4
  • Large Conductance Calcium-Dependent Potassium Ion Channel Beta 4 Subunit 3
  • Calcium-Activated Potassium Channel Subunit Beta-4 3

External Ids for KCNMB4 Gene

Previous GeneCards Identifiers for KCNMB4 Gene

  • GC12P070632
  • GC12P070476
  • GC12P069046
  • GC12P070760
  • GC12P067810

Summaries for KCNMB4 Gene

Entrez Gene Summary for KCNMB4 Gene

  • MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNMB4 Gene

KCNMB4 (Potassium Channel Subfamily M Regulatory Beta Subunit 4) is a Protein Coding gene. Among its related pathways are Platelet homeostasis and Hemostasis. GO annotations related to this gene include calcium-activated potassium channel activity. An important paralog of this gene is KCNMB1.

UniProtKB/Swiss-Prot for KCNMB4 Gene

  • Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.

Tocris Summary for KCNMB4 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNMB4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNMB4 Gene

Genomics for KCNMB4 Gene

Regulatory Elements for KCNMB4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCNMB4 Gene

Start:
70,366,276 bp from pter
End:
70,434,292 bp from pter
Size:
68,017 bases
Orientation:
Plus strand

Genomic View for KCNMB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNMB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNMB4 Gene

Proteins for KCNMB4 Gene

  • Protein details for KCNMB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86W47-KCMB4_HUMAN
    Recommended name:
    Calcium-activated potassium channel subunit beta-4
    Protein Accession:
    Q86W47
    Secondary Accessions:
    • Q8IVR3
    • Q9NPA4
    • Q9P0G5

    Protein attributes for KCNMB4 Gene

    Size:
    210 amino acids
    Molecular mass:
    23949 Da
    Quaternary structure:
    • Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB4 per KCNMA1 tetramer.
    Miscellaneous:
    • Treatment with okadaic acid reduces its effect on KCNMA1

neXtProt entry for KCNMB4 Gene

Proteomics data for KCNMB4 Gene at MOPED

Post-translational modifications for KCNMB4 Gene

  • N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin.
  • Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics.
  • Glycosylation at Asn53 and Asn90
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNMB4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KCNMB4 Gene

Domains for KCNMB4 Gene

Gene Families for KCNMB4 Gene

HGNC:
  • KCN :Potassium channels

Protein Domains for KCNMB4 Gene

Suggested Antigen Peptide Sequences for KCNMB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86W47

UniProtKB/Swiss-Prot:

KCMB4_HUMAN :
  • Q86W47
Domain:
  • Resistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain
Family:
  • Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB4 subfamily.
genes like me logo Genes that share domains with KCNMB4: view

Function for KCNMB4 Gene

Molecular function for KCNMB4 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.

Gene Ontology (GO) - Molecular Function for KCNMB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10692449
GO:0015269 calcium-activated potassium channel activity IDA 10692449
GO:0015459 potassium channel regulator activity IBA --
genes like me logo Genes that share ontologies with KCNMB4: view

Phenotypes for KCNMB4 Gene

genes like me logo Genes that share phenotypes with KCNMB4: view

Animal Models for KCNMB4 Gene

MGI Knock Outs for KCNMB4:

Animal Model Products

miRNA for KCNMB4 Gene

miRTarBase miRNAs that target KCNMB4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNMB4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KCNMB4 Gene

Localization for KCNMB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNMB4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNMB4 Gene COMPARTMENTS Subcellular localization image for KCNMB4 gene
Compartment Confidence
plasma membrane 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNMB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 10692449
GO:0008076 voltage-gated potassium channel complex IDA 10692449
GO:0016020 membrane --
genes like me logo Genes that share ontologies with KCNMB4: view

Pathways for KCNMB4 Gene

genes like me logo Genes that share pathways with KCNMB4: view

Pathways by source for KCNMB4 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for KCNMB4 Gene

Gene Ontology (GO) - Biological Process for KCNMB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001508 action potential IDA 10692449
GO:0005513 detection of calcium ion IDA 10692449
GO:0006813 potassium ion transport IDA 10692449
GO:0007268 synaptic transmission TAS --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with KCNMB4: view

Compounds for KCNMB4 Gene

(5) Tocris Compounds for KCNMB4 Gene

Compound Action Cas Number
4-Aminopyridine Non-selective KV channel blocker [504-24-5]
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
Margatoxin Potent KV1.3 channel blocker [145808-47-5]
MaxiPost Potassium channel modulator; exerts subtype-specific effects [187523-35-9]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents [122955-13-9]

(1) HMDB Compounds for KCNMB4 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for KCNMB4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Miconazole
22916-47-8 target inhibitor
genes like me logo Genes that share compounds with KCNMB4: view

Transcripts for KCNMB4 Gene

mRNA/cDNA for KCNMB4 Gene

Unigene Clusters for KCNMB4 Gene

Potassium large conductance calcium-activated channel, subfamily M, beta member 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNMB4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNMB4 Gene

No ASD Table

Relevant External Links for KCNMB4 Gene

GeneLoc Exon Structure for
KCNMB4
ECgene alternative splicing isoforms for
KCNMB4

Expression for KCNMB4 Gene

mRNA expression in normal human tissues for KCNMB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNMB4 Gene

This gene is overexpressed in Brain - Hippocampus (4.5).

Protein differential expression in normal tissues for KCNMB4 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNMB4 Gene

SOURCE GeneReport for Unigene cluster for KCNMB4 Gene Hs.525529

mRNA Expression by UniProt/SwissProt for KCNMB4 Gene

Q86W47-KCMB4_HUMAN
Tissue specificity: Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues.
genes like me logo Genes that share expressions with KCNMB4: view

Expression partners for KCNMB4 Gene

In Situ Assay Products

Orthologs for KCNMB4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNMB4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNMB4 35
  • 96.35 (n)
  • 99.05 (a)
KCNMB4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNMB4 35
  • 94.28 (n)
  • 95.96 (a)
KCNMB4 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnmb4 35
  • 91.59 (n)
  • 93.81 (a)
Kcnmb4 16
Kcnmb4 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNMB4 35
  • 99.84 (n)
  • 100 (a)
KCNMB4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnmb4 35
  • 92.22 (n)
  • 94.29 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNMB4 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNMB4 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNMB4 35
  • 72.7 (n)
  • 66.19 (a)
KCNMB4 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNMB4 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnmb4 35
  • 76.83 (n)
  • 80 (a)
Str.16311 35
Species with no ortholog for KCNMB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KCNMB4 Gene

ENSEMBL:
Gene Tree for KCNMB4 (if available)
TreeFam:
Gene Tree for KCNMB4 (if available)

Paralogs for KCNMB4 Gene

Paralogs for KCNMB4 Gene

Selected SIMAP similar genes for KCNMB4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCNMB4: view

Variants for KCNMB4 Gene

Sequence variations from dbSNP and Humsavar for KCNMB4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2852 -- 70,431,462(+) ATATA(A/C)ATGAT utr-variant-3-prime
rs2853 -- 70,431,429(+) TTGAC(A/G)GAGTT utr-variant-3-prime
rs8498 -- 70,430,918(-) AAAAT(A/G)AACTT utr-variant-3-prime, downstream-variant-500B
rs373031 -- 70,429,915(+) AAAAG(A/G)CACTC intron-variant
rs394571 -- 70,427,893(+) TGAAG(C/G)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNMB4 Gene

Variant ID Type Subtype PubMed ID
nsv899235 CNV Gain 21882294
dgv1445n71 CNV Gain+Loss 21882294
dgv1446n71 CNV Loss 21882294
esv275582 CNV Loss 21479260
nsv469463 CNV Gain 19166990
nsv899240 CNV Gain 21882294
esv993429 CNV Deletion 20482838
nsv764 CNV Insertion 18451855

Relevant External Links for KCNMB4 Gene

HapMap Linkage Disequilibrium report
KCNMB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNMB4 Gene

Disorders for KCNMB4 Gene

Relevant External Links for KCNMB4

Genetic Association Database (GAD)
KCNMB4
Human Genome Epidemiology (HuGE) Navigator
KCNMB4

No disorders were found for KCNMB4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KCNMB4 Gene

Publications for KCNMB4 Gene

  1. hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family. (PMID: 10828459) Behrens R. … Pongs O. (FEBS Lett. 2000) 2 3 4 23
  2. Phosphorylation-dependent functional coupling of hSlo calcium- dependent potassium channel and its hbeta 4 subunit. (PMID: 11790768) Jin P. … Levitan I.B. (J. Biol. Chem. 2002) 3 4 23
  3. Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. (PMID: 10692449) Brenner R. … Aldrich R.W. (J. Biol. Chem. 2000) 2 3 4
  4. A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. (PMID: 10792058) Meera P. … Toro L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  5. A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels. (PMID: 10804197) Weiger T.M. … Curtis R. (J. Neurosci. 2000) 3 4

Products for KCNMB4 Gene

Sources for KCNMB4 Gene

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