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KCNMB4 Gene

protein-coding   GIFtS: 58
GCID: GC12P070760

Potassium Large Conductance Calcium-Activated Channel, Subfamily...

  Search for KCNMB4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Large Conductance Calcium-Activated Channel, Subfamily M,
Beta Member 41 2
     hbeta42
Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-42 3     k(VCA)beta-42
Charybdotoxin Receptor Subunit Beta-42 3     Large Conductance Calcium-Dependent Potassium Ion Channel Beta 4 Subunit2
Maxi K Channel Subunit Beta-42 3     slo-beta-42
BKbeta42 3     Hbeta43
BK Channel Subunit Beta-42 3     K(VCA)beta-43
Calcium-Activated Potassium Channel Subunit Beta-42     Slo-beta-43

External Ids:    HGNC: 62891   Entrez Gene: 273452   Ensembl: ENSG000001356437   OMIM: 6052235   UniProtKB: Q86W473   

Export aliases for KCNMB4 gene to outside databases

Previous GC identifers: GC12P070632 GC12P070476 GC12P069046 GC12P067810


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNMB4 Gene:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to
the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the
pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta
subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of
current activation to more negative potentials than does the beta 1 subunit. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNMB4 Gene:
KCNMB4 (potassium large conductance calcium-activated channel, subfamily M, beta member 4) is a protein-coding gene. GO annotations related to this gene include calcium-activated potassium channel activity. An important paralog of this gene is KCNMB2.

UniProtKB/Swiss-Prot: KCMB4_HUMAN, Q86W47
Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium
sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating
kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1
channel openings at low calcium concentrations but increases channel openings at high calcium concentrations.
Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations

summary for KCNMB4 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNMB4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNMB4 gene promoter:
         E2F-4   E2F-3a   E2F-5   MyoD   E2F-2   FOXL1   E2F   E2F-1   HFH-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNMB4 promoter sequence
   Search Chromatin IP Primers for KCNMB4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNMB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q15

KCNMB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNMB4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P070760:  view genomic region     (about GC identifiers)

Start:
70,760,056 bp from pter      End:
70,828,072 bp from pter
Size:
68,017 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCMB4_HUMAN, Q86W47 (See protein sequence)
Recommended Name: Calcium-activated potassium channel subunit beta-4  
Size: 210 amino acids; 23949 Da
Subunit: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB4 per KCNMA1 tetramer
Miscellaneous: Treatment with okadaic acid reduces its effect on KCNMA1
Secondary accessions: Q8IVR3 Q9NPA4 Q9P0G5

Explore the universe of human proteins at neXtProt for KCNMB4: NX_Q86W47

Explore proteomics data for KCNMB4 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics1
  • N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the
    interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin1
  • Glycosylation2 at Asn53, Asn90
  • Modification sites at PhosphoSitePlus

  • See KCNMB4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055320.4  
    ENSEMBL proteins: 
     ENSP00000258111   ENSP00000431137  
    Reactome Protein details: Q86W47

    KCNMB4 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for KCNMB4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels

    1 InterPro protein domain:
     IPR003930 K_chnl_Ca-activ_BK_bsu

    Graphical View of Domain Structure for InterPro Entry Q86W47

    ProtoNet protein and cluster: Q86W47

    1 Blocks protein domain: IPB003930 Calcium-activated BK potassium channel beta subunit signature

    UniProtKB/Swiss-Prot: KCMB4_HUMAN, Q86W47
    Domain: Resistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain
    Similarity: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB4 subfamily


    Find genes that share domains with KCNMB4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCMB4_HUMAN, Q86W47
    Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium
    sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating
    kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1
    channel openings at low calcium concentrations but increases channel openings at high calcium concentrations.
    Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10692449
    GO:0015269calcium-activated potassium channel activity IDA10692449
         
    Find genes that share ontologies with KCNMB4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KCNMB4:
     High actin ratio cells 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kcnmb4):
     behavior/neurological  hearing/vestibular/ear  nervous system  normal 

    Find genes that share phenotypes with KCNMB4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for KCNMB4: Kcnmb4tm1Rwa Kcnmb4tm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNMB4
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    miRNA
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    hsa-mir-192-5p (MIRT026374), hsa-mir-215-5p (MIRT024739)

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    4 qRT-PCR Assays for microRNAs that regulate KCNMB4:
    hsa-miR-562 hsa-miR-550a hsa-miR-1539 hsa-miR-1976
    SwitchGear 3'UTR luciferase reporter plasmidKCNMB4 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCMB4_HUMAN, Q86W47: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA10692449
    GO:0008076voltage-gated potassium channel complex IDA10692449
    GO:0016020membrane ----

    Find genes that share ontologies with KCNMB4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNMB4 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Insulin secretion
    Insulin secretion0.36
    Ca2+ activated K+ channels0.00
    2Nitric oxide stimulates guanylate cyclase
    Nitric oxide stimulates guanylate cyclase
    cGMP effects0.00
    3Transmission across Chemical Synapses
    Neuronal System0.68
    4Hemostasis
    Hemostasis0.43
    5Potassium Channels
    Potassium Channels0.43


    Find genes that share SuperPaths with KCNMB4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for KCNMB4
        Ca2+ activated K+ channels
    cGMP effects


    2 Kegg Pathways  (Kegg details for KCNMB4):
        Vascular smooth muscle contraction
    Insulin secretion

        Pathway & Disease-focused RT2 Profiler PCR Array including KCNMB4: 
              Neuronal Ion Channels in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for KCNMB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for KCNMB4 (ENSP000002581114) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNMA1ENSP000002866274STRING: ENSP00000286627
    KCNMB1ENSP000002746294STRING: ENSP00000274629
    PRKG2ENSP000002643994STRING: ENSP00000264399
    PRKACAENSP000003095914STRING: ENSP00000309591
    PRKACBENSP000003597194STRING: ENSP00000359719
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001508action potential IDA10692449
    GO:0005513detection of calcium ion IDA10692449
    GO:0006813potassium ion transport IDA10692449
    GO:0007268synaptic transmission TAS--
    GO:0007596blood coagulation TAS--

    Find genes that share ontologies with KCNMB4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNMB4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    1 HMDB Compound for KCNMB4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for KCNMB4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Miconazole-- 22916-47-8targetinhibitor8760033 1376313



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCNMB4 gene: 
    NM_014505.5  

    Unigene Cluster for KCNMB4:

    Potassium large conductance calcium-activated channel, subfamily M, beta member 4
    Hs.525529  [show with all ESTs]
    Unigene Representative Sequence: NM_014505
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258111(uc001svx.3) ENST00000531884
    miRNA
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    hsa-miR-562 hsa-miR-550a hsa-miR-1539 hsa-miR-1976
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      QuantiFast Probe-based Assays in human, mouse, rat KCNMB4

    Additional mRNA sequence: 

    AF160967.1 AF207992.1 AF215891.1 AK054684.1 BC037898.1 BC042446.2 BC047427.1 BC050621.1 

    3 DOTS entries:

    DT.455812  DT.100752407  DT.99979169 

    Selected AceView cDNA sequences (see all 121):

    AF207992 AW009009 CR613566 AI253037 Z40594 R44201 AA418442 BE856526 
    CB054146 AI431742 AW574931 BU556960 C20762 AA897123 AI631530 NM_014505 
    AI420085 AI934993 BC042446 AA897143 AF215891 AA280547 CR614941 AI674247 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNMB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAAGCGCA
    KCNMB4 Expression
    About this image


    KCNMB4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
             Medulla Oblongata
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Neurons
             Cholinergic Amacrine Cells Inner Nuclear Layer
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 7
    KCNMB4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNMB4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525529

    UniProtKB/Swiss-Prot: KCMB4_HUMAN, Q86W47
    Tissue specificity: Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral
    cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus,
    corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including KCNMB4: 
              Neuronal Ion Channels in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNMB4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KCNMB4 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnmb41 , 5 potassium large conductance calcium-activated channel, more1, 5 91.59(n)1
    93.81(a)1
      10 (64.73 cM)5
    588021  NM_021452.11  NP_067427.11 
     1164178615 
    chicken
    (Gallus gallus)
    Aves KCNMB41 potassium large conductance calcium-activated channel, more 72.7(n)
    66.19(a)
      417852  NM_001199630.1  NP_001186559.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNMB46
    potassium large conductance calcium-activated chan...
    50(a)
    1 ↔ 1
    GL343256.1(1954600-2005923)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.163112 Transcribed sequence with weak similarity to protein more 78.97(n)    142010670 


    ENSEMBL Gene Tree for KCNMB4 (if available)
    TreeFam Gene Tree for KCNMB4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNMB4 gene
    KCNMB22  KCNMB32  KCNMB12  
    2 SIMAP similar genes for KCNMB4 using alignment to 2 protein entries:     KCMB4_HUMAN (see all proteins):
    KCNMB3    KCNMB2

    Find genes that share paralogs with KCNMB4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNMB4 (see all 1311)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1923399351,2
    --70758219(+) GATCTC/TAGACA 1 -- us2k10--------
    rs773726881,2
    C,F--70758255(+) GATTAT/CAACAA 1 -- us2k11Minor allele frequency- C:0.11EA 120
    rs1445870281,2
    --70758265(+) ATAGAA/GAAAAA 1 -- us2k10--------
    rs741040091,2
    C,F--70758271(+) AAAAAA/GGATTA 1 -- us2k12Minor allele frequency- G:0.09WA 120
    rs1167865181,2
    C,F--70758500(+) TGGACG/TTTTTT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1844992291,2
    --70758547(+) CACTTA/GGGATC 1 -- us2k10--------
    rs1403852211,2
    --70758639(+) TGCAGG/TCGAAA 1 -- us2k10--------
    rs1173978611,2
    --70758641(+) CAGTCG/TAAAGG 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs123104171,2
    C,F--70758664(+) GTTAAG/ATAACA 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs1907842871,2
    --70758704(+) TTCCAA/TGATTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNMB4 (70760056 - 70828072 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for KCNMB4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv993429CNV Deletion20482838
    nsv764CNV Insertion18451855
    esv275582CNV Loss21479260
    dgv1446n71CNV Loss21882294
    nsv899240CNV Gain21882294
    nsv469463CNV Gain19166990
    nsv899235CNV Gain21882294
    dgv1445n71CNV Gain+Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNMB4
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNMB4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605223    OMIM disorders: --


    Find genes that share disorders with KCNMB4           About GenesLikeMe

    Genetic Association Database (GAD): KCNMB4
    Human Genome Epidemiology (HuGE) Navigator: KCNMB4 (1 document)

    Export disorders for KCNMB4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNMB4 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with KCNMB4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family. (PubMed id 10828459)1, 2, 3, 9 Behrens R....Pongs O. (FEBS Lett. 2000)
    2. Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. (PubMed id 10692449)1, 2, 3 Brenner R.... Aldrich R.W. (J. Biol. Chem. 2000)
    3. Phosphorylation-dependent functional coupling of hSlo calcium- dependent potassium channel and its hbeta 4 subunit. (PubMed id 11790768)1, 2, 9 Jin P.... Levitan I.B. (J. Biol. Chem. 2002)
    4. Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study. (PubMed id 17913586)1, 4 Cavalleri G.L....Goldstein D.B. (Lancet Neurol 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Reciprocal modulation between the alpha and beta 4 subunits of hSlo calcium-dependent potassium channels. (PubMed id 12223479)1, 2 Jin P.... Levitan I.B. (J. Biol. Chem. 2002)
    7. New disguises for an old channel: MaxiK channel beta-subunits. (PubMed id 12136044)1, 2 Orio P.... Latorre R. (News Physiol. Sci. 2002)
    8. A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels. (PubMed id 10804197)1, 2 Weiger T.M.... Curtis R. (J. Neurosci. 2000)
    9. A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. (PubMed id 10792058)1, 2 Meera P.... Toro L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    10. Failure to confirm association of a polymorphism in KCNMB4 gene with mesial temporal lobe epilepsy. (PubMed id 23623847)1 Manna I....Gambardella A. (Epilepsy Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27345 HGNC: 6289 AceView: KCNMB4 Ensembl:ENSG00000135643 euGenes: HUgn27345
    ECgene: KCNMB4 Kegg: 27345 H-InvDB: KCNMB4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCNMB4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCNMB4 gene:
    Search GeneIP for patents involving KCNMB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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