Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNMB4 Gene

protein-coding   GIFtS: 57
GCID: GC12P070760

Potassium Large Conductance Calcium-Activated Channel, Subfamily...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Large Conductance Calcium-Activated Channel, Subfamily M,
Beta Member 41 2
     hbeta42
Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-42 3     k(VCA)beta-42
Charybdotoxin Receptor Subunit Beta-42 3     Large Conductance Calcium-Dependent Potassium Ion Channel Beta 4 Subunit2
Maxi K Channel Subunit Beta-42 3     slo-beta-42
BKbeta42 3     Hbeta43
BK Channel Subunit Beta-42 3     K(VCA)beta-43
Calcium-Activated Potassium Channel Subunit Beta-42     Slo-beta-43

External Ids:    HGNC: 62891   Entrez Gene: 273452   Ensembl: ENSG000001356437   OMIM: 6052235   UniProtKB: Q86W473   

Export aliases for KCNMB4 gene to outside databases

Previous GC identifers: GC12P070632 GC12P070476 GC12P069046 GC12P067810


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNMB4 Gene:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to
the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the
pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta
subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of
current activation to more negative potentials than does the beta 1 subunit. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNMB4 Gene: 
KCNMB4 (potassium large conductance calcium-activated channel, subfamily M, beta member 4) is a protein-coding gene. Diseases associated with KCNMB4 include epilepsy syndrome, and alcoholism, and among its related super-pathways are cGMP effects and Transmission across Chemical Synapses. GO annotations related to this gene include protein binding and calcium-activated potassium channel activity. An important paralog of this gene is KCNMB2.

UniProtKB/Swiss-Prot: KCMB4_HUMAN, Q86W47
Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium
sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating
kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1
channel openings at low calcium concentrations but increases channel openings at high calcium concentrations.
Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations

summary for KCNMB4 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNMB4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNMB4 gene promoter:
         E2F-4   E2F-3a   E2F-5   MyoD   E2F-2   FOXL1   E2F   E2F-1   HFH-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNMB4 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNMB4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNMB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q15

KCNMB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNMB4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P070760:  view genomic region     (about GC identifiers)

Start:
70,760,056 bp from pter      End:
70,828,072 bp from pter
Size:
68,017 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCMB4_HUMAN, Q86W47 (See protein sequence)
Recommended Name: Calcium-activated potassium channel subunit beta-4  
Size: 210 amino acids; 23949 Da
Subunit: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB4 per KCNMA1 tetramer
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Treatment with okadaic acid reduces its effect on KCNMA1
Secondary accessions: Q8IVR3 Q9NPA4 Q9P0G5

Explore the universe of human proteins at neXtProt for KCNMB4: NX_Q86W47

Explore proteomics data for KCNMB4 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics
  • UniProtKB: N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the
    interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86W47

  • KCNMB4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCNMB4 Protein Expression
    REFSEQ proteins: NP_055320.4  
    ENSEMBL proteins: 
     ENSP00000258111   ENSP00000431137  
    Reactome Protein details: Q86W47
    Human Recombinant Protein Products for KCNMB4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KCNMB4
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for KCNMB4
    GenScript Custom Purified and Recombinant Proteins Services for KCNMB4
    Novus Biologicals KCNMB4 Protein
    Novus Biologicals KCNMB4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA10692449
    GO:0008076voltage-gated potassium channel complex IDA10692449
    GO:0016020membrane ----

    KCNMB4 for ontologies           About GeneDecksing



    KCNMB4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNMB4
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KCNMB4
    GenScript Custom Superior Antibodies Services for KCNMB4
    Novus Biologicals KCNMB4 Antibodies
    Abcam antibodies for KCNMB4
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for KCNMB4
    LSBio Antibodies in human, mouse, rat for KCNMB4 

    Assay Products for KCNMB4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KCNMB4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KCNMB4
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KCN: Potassium channels

    1 InterPro protein domain:
     IPR003930 K_chnl_Ca-activ_BK_bsu

    Graphical View of Domain Structure for InterPro Entry Q86W47

    ProtoNet protein and cluster: Q86W47

    1 Blocks protein domain: IPB003930 Calcium-activated BK potassium channel beta subunit signature

    UniProtKB/Swiss-Prot: KCMB4_HUMAN, Q86W47
    Domain: Resistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain
    Similarity: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB4 subfamily


    KCNMB4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCMB4_HUMAN, Q86W47
    Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium
    sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating
    kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1
    channel openings at low calcium concentrations but increases channel openings at high calcium concentrations.
    Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10692449
    GO:0015269calcium-activated potassium channel activity IDA10692449
         
    KCNMB4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KCNMB4:
     High actin ratio cells 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kcnmb4):
     behavior/neurological  hearing/vestibular/ear  nervous system  normal 

    KCNMB4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KCNMB4: Kcnmb4tm1Rwa Kcnmb4tm1Lex

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KCNMB4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KCNMB4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCNMB4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCNMB4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNMB4
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNMB4:
    hsa-miR-562 hsa-miR-550a hsa-miR-1539 hsa-miR-1976
    SwitchGear 3'UTR luciferase reporter plasmidKCNMB4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KCNMB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNMB4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KCNMB4
    Sirion Biotech Customized adenovirus for overexpression of KCNMB4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KCNMB4 (see all 7)
    OriGene ORF clones in mouse, rat for KCNMB4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCNMB4 (NM_014505)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNMB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNMB4
    Sirion Biotech Customized lentivirus for stable overexpression of KCNMB4 
                         Customized lentivirus expression plasmids for stable overexpression of KCNMB4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KCNMB4
    Search LifeMap BioReagents cell lines for KCNMB4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNMB4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KCNMB4 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nitric oxide stimulates guanylate cyclase
    Nitric oxide stimulates guanylate cyclase0.75
    Platelet homeostasis0.34
    cGMP effects0.75
    2Transmission across Chemical Synapses
    Neuronal System0.67
    3Potassium Channels
    Potassium Channels0.43
    4Platelet activation, signaling and aggregation
    Hemostasis0.43
    5Insulin secretion
    Insulin secretion0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KCNMB4
        Synaptic transmission- ion currents


    5/7        Reactome Pathways for KCNMB4 (see all 7)
        Hemostasis
    Potassium Channels
    Ca2+ activated K+ channels
    cGMP effects
    Platelet homeostasis


    2         Kegg Pathways  (Kegg details for KCNMB4):
        Vascular smooth muscle contraction
    Insulin secretion


    KCNMB4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNMB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for KCNMB4 (ENSP000002581114) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNMA1ENSP000002866274STRING: ENSP00000286627
    KCNMB1ENSP000002746294STRING: ENSP00000274629
    PRKG2ENSP000002643994STRING: ENSP00000264399
    PRKACAENSP000003095914STRING: ENSP00000309591
    PRKACBENSP000003597194STRING: ENSP00000359719
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001508regulation of action potential IDA10692449
    GO:0005513detection of calcium ion IDA10692449
    GO:0006813potassium ion transport IDA10692449
    GO:0007268synaptic transmission TAS--
    GO:0007596blood coagulation TAS--

    KCNMB4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNMB4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    1 HMDB Compound for KCNMB4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for KCNMB4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Miconazole-- 22916-47-8targetinhibitor8760033 1376313

    Search CenterWatch for drugs/clinical trials and news about KCNMB4 / KCMB4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KCNMB4 gene: 
    NM_014505.5  

    Unigene Cluster for KCNMB4:

    Potassium large conductance calcium-activated channel, subfamily M, beta member 4
    Hs.525529  [show with all ESTs]
    Unigene Representative Sequence: NM_014505
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258111(uc001svx.3) ENST00000531884
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNMB4
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNMB4:
    hsa-miR-562 hsa-miR-550a hsa-miR-1539 hsa-miR-1976
    SwitchGear 3'UTR luciferase reporter plasmidKCNMB4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KCNMB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNMB4
    Clone
    Products:
         
    OriGene clones in human, mouse for KCNMB4 (see all 7)
    OriGene ORF clones in mouse, rat for KCNMB4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCNMB4 (NM_014505)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNMB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNMB4
    Sirion Biotech Customized lentivirus for stable overexpression of KCNMB4 
                         Customized lentivirus expression plasmids for stable overexpression of KCNMB4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KCNMB4
    OriGene qSTAR qPCR primer pairs in human, mouse for KCNMB4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNMB4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNMB4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNMB4

    Additional mRNA sequence: 

    AF160967.1 AF207992.1 AF215891.1 AK054684.1 BC037898.1 BC042446.2 BC047427.1 BC050621.1 

    3 DOTS entries:

    DT.455812  DT.100752407  DT.99979169 

    24/121 AceView cDNA sequences (see all 121):

    AA897143 AA897123 NM_014505 BE856526 Z44262 AI204969 AA280547 BC042446 
    C20762 AW009009 BU556960 Z40594 AI253037 CR613566 AF207992 AI934993 
    BI821301 AW574931 AA418442 CR614941 AI674247 CB054146 AI420085 R85016 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNMB4 expression in normal human tissues (normalized intensities)      KCNMB4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAAGCGCA
    KCNMB4 Expression
    About this image


    KCNMB4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Endothelial Cells Blood Brain Barrier
             Medulla Oblongata
             hippocampus   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Mesencephalic Ventricular Zone
             spinal cord/lateral wall/ventricular layer   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/naris   
     
     Tooth (Integumentary System)    fully expand to see all 2 entries
             visceral organ/oral region/upper jaw   
     
     Blood Brain Barrier (Nervous System)
             Endothelial Cells Blood Brain Barrier

    See KCNMB4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNMB4

    SOURCE GeneReport for Unigene cluster: Hs.525529

    UniProtKB/Swiss-Prot: KCMB4_HUMAN, Q86W47
    Tissue specificity: Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral
    cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus,
    corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues

        SABiosciences Expression via Pathway-Focused PCR Array including KCNMB4: 
              Neuronal Ion Channels in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KCNMB4
    OriGene qSTAR qPCR primer pairs in human, mouse for KCNMB4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNMB4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNMB4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNMB4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNMB4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KCNMB4 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnmb41 , 5 potassium large conductance calcium-activated channel, more1, 5 91.59(n)1
    93.81(a)1
      10 (64.73 cM)5
    588021  NM_021452.11  NP_067427.11 
     1164178615 
    chicken
    (Gallus gallus)
    Aves KCNMB41 potassium large conductance calcium-activated channel, more 72.7(n)
    66.19(a)
      417852  NM_001199630.1  NP_001186559.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNMB46
    Uncharacterized protein
    47(a)
    1 ↔ 1
    GL343256.1(1954600-2005923)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.163112 Transcribed sequence with weak similarity to protein more 78.97(n)    142010670 


    ENSEMBL Gene Tree for KCNMB4 (if available)
    TreeFam Gene Tree for KCNMB4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNMB4 gene
    KCNMB22  KCNMB32  KCNMB12  
    2 SIMAP similar genes for KCNMB4 using alignment to 2 protein entries:     KCMB4_HUMAN (see all proteins):
    KCNMB3    KCNMB2

    KCNMB4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1311 SNPs in KCNMB4 are shown (see all 1311)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0181784
    ----see VAR_0181782 V I mis40--------
    rs1923399351,2
    --70758219(+) GATCTC/TAGACA 1 -- us2k10--------
    rs773726881,2
    C,F--70758255(+) GATTAT/CAACAA 1 -- us2k11Minor allele frequency- C:0.11EA 120
    rs1445870281,2
    --70758265(+) ATAGAA/GAAAAA 1 -- us2k10--------
    rs741040091,2
    C,F--70758271(+) AAAAAA/GGATTA 1 -- us2k12Minor allele frequency- G:0.09WA 120
    rs1167865181,2
    C,F--70758500(+) TGGACG/TTTTTT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1844992291,2
    --70758547(+) CACTTA/GGGATC 1 -- us2k10--------
    rs1403852211,2
    --70758639(+) TGCAGG/TCGAAA 1 -- us2k10--------
    rs1173978611,2
    --70758641(+) CAGTCG/TAAAGG 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs123104171,2
    C,F--70758664(+) GTTAAG/ATAACA 1 -- us2k11Minor allele frequency- A:0.07WA 118

    HapMap Linkage Disequilibrium report for KCNMB4 (70760056 - 70828072 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for KCNMB4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv993429CNV Deletion20482838
    nsv764CNV Insertion18451855
    esv275582CNV Loss21479260
    dgv1446n71CNV Loss21882294
    nsv899240CNV Gain21882294
    nsv469463CNV Gain19166990
    nsv899235CNV Gain21882294
    dgv1445n71CNV Gain+Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNMB4
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNMB4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605223    OMIM disorders: --

    4 diseases for KCNMB4:    About MalaCards
    epilepsy syndrome    alcoholism    cerebritis    neuronitis


    KCNMB4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KCNMB4
    Human Genome Epidemiology (HuGE) Navigator: KCNMB4 (1 document)

    Export disorders for KCNMB4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNMB4 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with KCNMB4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family. (PubMed id 10828459)1, 2, 3, 9 Behrens R....Pongs O. (2000)
    2. Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. (PubMed id 10692449)1, 2, 3 Brenner R.... Aldrich R.W. (2000)
    3. Phosphorylation-dependent functional coupling of hSlo calcium- dependent potassium channel and its hbeta 4 subunit. (PubMed id 11790768)1, 2, 9 Jin P.... Levitan I.B. (2002)
    4. Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study. (PubMed id 17913586)1, 4 Cavalleri G.L....Goldstein D.B. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Reciprocal modulation between the alpha and beta 4 subunits of hSlo calcium-dependent potassium channels. (PubMed id 12223479)1, 2 Jin P.... Levitan I.B. (2002)
    7. New disguises for an old channel: MaxiK channel beta-subunits. (PubMed id 12136044)1, 2 Orio P.... Latorre R. (2002)
    8. A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels. (PubMed id 10804197)1, 2 Weiger T.M.... Curtis R. (2000)
    9. A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. (PubMed id 10792058)1, 2 Meera P.... Toro L. (2000)
    10. Modulation by the BK accessory I^4 subunit of phosphor ylation-dependent changes in excitability of dentate gyrus granule neurons. (PubMed id 21848922)1 Petrik D....Brenner R. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27345 HGNC: 6289 AceView: KCNMB4 Ensembl:ENSG00000135643 euGenes: HUgn27345
    ECgene: KCNMB4 Kegg: 27345 H-InvDB: KCNMB4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNMB4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCNMB4 gene:
    Search GeneIP for patents involving KCNMB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNMB4
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KCNMB4  
     OriGene qPCR primer pairs and template standards for KCNMB4   OriGene Protein Over-expression Lysate for KCNMB4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KCNMB4  
     OriGene qSTAR qPCR primer pairs in human, mouse for KCNMB4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KCNMB4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KCNMB4   OriGene Custom Protein Services for KCNMB4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNMB4
     QIAGEN SeqTarget long-range PCR primers for resequencing KCNMB4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNMB4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNMB4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNMB4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNMB4
     GenScript Custom Purified and Recombinant Proteins Services for KCNMB4 GenScript cDNA clones with any tag delivered in your preferred vector for KCNMB4
     GenScript Custom Assay Services for KCNMB4 GenScript Custom Superior Antibodies Services for KCNMB4
     GenScript Custom overexpressing Cell Line Services for KCNMB4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KCNMB4 promoter
     Search Chromatin IP Primers for KCNMB4
     RT2 qPCR Primer Assay in human, mouse, rat KCNMB4
     Search GNC Networks for KCNMB4
     SABiosciences PCR Arrays including human, mouse, rat KCNMB4
     Tocris compounds for KCNMB4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KCNMB4 antibodies
     KCNMB4 proteins
     KCNMB4 lysates
     Antibodies for KCNMB4
     See all of Abcam's Antibodies, Kits and Proteins for KCNMB4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for KCNMB4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNMB4
     SwitchGear 3'UTR luciferase reporter plasmids for KCNMB4
     SwitchGear Promoter luciferase reporter plasmids for KCNMB4
     Search ThermoFisher Antibodies for KCNMB4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNMB4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KCNMB4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KCNMB4
    Customized:
     lentivirus for stable overexpression of KCNMB4
     lentivirus expression plasmids for stable overexpression of KCNMB4
     adenovirus for overexpression of KCNMB4
     LSBio Antibodies in human, mouse, rat for KCNMB4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KCNMB4 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4