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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNMB3 Gene

protein-coding   GIFtS: 56
GCID: GC03M178957

potassium large conductance calcium-activated channel, subfamily...


(Previous symbols: KCNMB2, KCNMBL)
 Explore 3 diseases affiliated with
KCNMB3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCNMB3    

Aliases
for KCNMB3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Potassium Large Conductance Calcium-Activated Channel, Subfamily M Beta
Member 31 2
     HBETA32
KCNMB21 2 3     SLOBETA32
KCNMBL1 2 3     Calcium-Activated Potassium Channel Subunit Beta-32
Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-32 3     Large Conductance, Voltage And Ca2+ Activated Potassium Channel Maxi K Beta 3
Subunit2
Charybdotoxin Receptor Subunit Beta-32 3     Slo-Beta-31
Maxi K Channel Subunit Beta-32 3     BKbeta33
K(VCA)Beta-31     Hbeta33
BK Channel Subunit Beta-32 3     Slo-Beta-31
BKBETA32     

External Ids:    HGNC: 62871   Entrez Gene: 270942   Ensembl: ENSG000001711217   OMIM: 6052225   UniProtKB: Q9NPA13   
ORGUL members:         
NONCODE:n408156    

Export aliases for KCNMB3 gene to outside databases

Previous GC identifers: GC03M175611 GC03M179800 GC03M180359 GC03M180278 GC03M180281 GC03M180440 GC03M176360


Summaries
for KCNMB3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KCNMB3:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the
control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming
alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may
partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing
results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. (provided by
RefSeq, Jul 2009)

UniProtKB/Swiss-Prot: KCMB3_HUMAN, Q9NPA1
Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium
sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional
properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the
current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at
large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits
of KCNMB3 are required to block the KCNMA1 tetramer

summary for KCNMB3:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNMB3


Genomic Views
for KCNMB3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNMB3 gene promoter:
         RORalpha1   RelA   CUTL1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNMB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNMB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNMB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.3-q27   Ensembl cytogenetic band:  3q26.32   HGNC cytogenetic band: 3q26.3-q27

KCNMB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNMB3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M178957:  view genomic region     (about GC identifiers)

Start:
 178,957,530 bp from pter      End:
 178,984,838 bp from pter
Size:
 27,309 bases      Orientation:
 minus strand

Proteins
for KCNMB3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCMB3_HUMAN, Q9NPA1 (See protein sequence)
Recommended Name: Calcium-activated potassium channel subunit beta-3  
Size: 279 amino acids; 31604 Da
Subunit: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB3 per KCNMA1 tetramer
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B7Z9C9 D3DNR2 E9PER5 Q9NPG7 Q9NRM9 Q9UHN3
Alternative splicing: 5 isoforms:  Q9NPA1-1   Q9NPA1-2   Q9NPA1-3   Q9NPA1-4   Q9NPA1-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KCNMB3: NX_Q9NPA1

Post-translational modifications:

  • N-glycosylated1
  • The extracellular domain contains disulfide bond essential for the gating mechanism1
  • View neXtProt modification sites for NX_Q9NPA1

    • KCNMB3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001157149.1  NP_055222.3  NP_741979.1  NP_741980.1  NP_741981.1  

    ENSEMBL proteins: 
     ENSP00000417091   ENSP00000376452   ENSP00000376451   ENSP00000327866   ENSP00000319370  
     ENSP00000418536  
    Reactome Protein details: Q9NPA1
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    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA10692449
    GO:0008076voltage-gated potassium channel complex IDA10692449
    GO:0016020membrane ----


    KCNMB3 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for KCNMB3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCNMB3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003930 K_chnl_Ca-activ_BK_bsu

    Graphical View of Domain Structure for InterPro Entry Q9NPA1

    ProtoNet protein and cluster: Q9NPA1

    2 Blocks protein families:
    IPB003930 Calcium-activated BK potassium channel beta subunit signature
    IPB008162 Inorganic pyrophosphatase


    UniProtKB/Swiss-Prot: KCMB3_HUMAN, Q9NPA1
    Domain: Isoform 4 cytoplasmic N-terminus domain participates in the partial inactivation of KCNMA1, possibly by binding
    to a receptor site
    Domain: The extracellular domain forms gates to block ion permeation, providing a mechanism by which current can be
    rapidly diminished upon cellular repolarization
    Similarity: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily


    Function
    for KCNMB3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCMB3_HUMAN, Q9NPA1
    Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium
    sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional
    properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the
    current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at
    large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits
    of KCNMB3 are required to block the KCNMA1 tetramer

         Genatlas biochemistry entry for KCNMB3:
    potassium non voltage gated large conductance calcium activated channel,subfamily M,Maxik,fundamental in the control of
    smooth muscle tone and neuronal excitability, modulatory beta member 3,predominantly expressed in pancreas,situated in
    the duplication region dup(Bq),see KCNMA1

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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015269calcium-activated potassium channel activity IDA10692449
    GO:0015459potassium channel regulator activity NAS10792058


    KCNMB3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for KCNMB3:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for KCNMB3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Nitric oxide stimulates guanylate cyclase
    		Nitric oxide stimulates guanylate cyclase1.00
    		Platelet homeostasis0.34
    		cGMP effects0.75
    2Potassium Channels
    		Potassium Channels1.00
    3Ca2+ activated K+ channels
    		Ca2+ activated K+ channels1.00
    4Transmission across Chemical Synapses
    		Neuronal System0.67
    5Platelet activation, signaling and aggregation
    		Hemostasis0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/7        Reactome Pathways for KCNMB3 (see all 7)
        Hemostasis
    Potassium Channels
    Ca2+ activated K+ channels
    cGMP effects
    Platelet homeostasis


    1         Kegg Pathway  (Kegg details for KCNMB3):
        Vascular smooth muscle contraction


    KCNMB3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNMB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for KCNMB3 (ENSP000003193704) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKACAENSP000003095914STRING: ENSP00000309591
    PRKACBENSP000003597194STRING: ENSP00000359719
    PRKACGENSP000003664884STRING: ENSP00000366488
    PRKG1ENSP000003630924STRING: ENSP00000363092
    PRKXENSP000002628484STRING: ENSP00000262848
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001508regulation of action potential IDA10692449
    GO:0005513detection of calcium ion IDA10692449
    GO:0006813potassium ion transport IDA10692449
    GO:0007268synaptic transmission TAS--
    GO:0007596blood coagulation TAS--


    KCNMB3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCNMB3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNMB3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AM 92016 hydrochlorideKV channel blocker[178894-81-0]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    4-AminopyridineNon-selective KV channel blocker[504-24-5]

    2 HMDB Compounds for KCNMB3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PotassiumK+ (see all 16)7440-09-7--

    1 DrugBank Compound for KCNMB3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Miconazole-- 22916-47-8targetinhibitor8760033 1376313

    Search CenterWatch for drugs/clinical trials and news about KCNMB3 / KCMB3 

    Transcripts
    for KCNMB3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCNMB3 gene (5 alternative transcripts): 
    NM_001163677.1  NM_014407.3  NM_171828.1  NM_171829.2  NM_171830.1  

    Unigene Cluster for KCNMB3:

    Potassium large conductance calcium-activated channel, subfamily M beta member 3
    Hs.591285  [show with all ESTs]
    Unigene Representative Sequence: NR_028135
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486944 ENST00000497599(uc011bqc.1) ENST00000392686(uc003fjl.3 uc003fjo.3)
    ENST00000392685(uc003fjm.3 uc003fjn.3) ENST00000349697(uc003fjp.1)
    ENST00000314235 ENST00000485523

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    Inhib. RNA
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    Additional cDNA sequence: 

    AF139471.1 AF160968.1 AF170916.1 AF214561.1 AK304837.1 BC082272.1 BC113851.1 NR_028135.1 

    7 DOTS entries:

    DT.92416406  DT.95319032  DT.99950166  DT.102836106  DT.120858776  DT.120663210  DT.86853337 

    24/31 AceView cDNA sequences (see all 31):

    NM_014407 NM_171830 AI823768 NM_171829 NM_171828 BC082272 AA761761 AW297141 
    AI816873 CD625664 CD625660 CD625656 AA934876 AF214561 BF027384 CD625662 
    BM745010 CD625652 AF139471 CD625666 AF170916 AF160968 BX113095 AA917510 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KCNMB3    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:              -     -                                 
    SP2:                                                      
    SP3:                                                      
    SP4:        -     -     -                                 


    ECgene alternative splicing isoforms for KCNMB3

    Expression
    for KCNMB3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNMB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See KCNMB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNMB3

    SOURCE GeneReport for Unigene cluster: Hs.591285

    UniProtKB/Swiss-Prot: KCMB3_HUMAN, Q9NPA1
    Tissue specificity: Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas,
    kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis

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    In Situ
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    Orthologs
    for KCNMB3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for KCNMB3 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.162492 Transcribed sequence with weak similarity to protein more 75.51(n)    BX716835.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CT027646.16
    		 --
    		 30(a)
    		 1 ↔ 1
    		 2(7616432-7629401)


    ENSEMBL Gene Tree for KCNMB3 (if available)
    TreeFam Gene Tree for KCNMB3 (if available) 

    Paralogs
    for KCNMB3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNMB3 gene
    KCNMB22  KCNMB42  KCNMB12  
    3 SIMAP similar genes for KCNMB3 using alignment to 2 protein entries:     KCMB3_HUMAN (see all proteins):
    KCNMB2    KCNMB4    KCNMB1

    KCNMB3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KCNMB3
    PGOHUM00000259680


    Genomic Variants
    for KCNMB3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/577 NCBI SNPs in KCNMB3 are shown (see all 577)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1925143351,2
    		--178957176(+) TTAGAC/GTAAAC 2 -- ds50010--------
    rs1405347351,2
    		--178957209(+) AAATC-/ATTATCTA 2 -- ds50010--------
    rs1846518631,2
    		--178957300(+) GAGGTC/TGGAGA 2 -- ds50010--------
    rs1889284361,2
    		--178957520(+) AAATTC/TGAACC 2 -- ds50010--------
    rs1813414821,2
    		--178957677(+) CAAGAC/TGCATG 2 -- nc-transcript-variantut310--------
    rs40961271,2
    		--178957684(-) AGTAAC/TACATG 2 -- nc-transcript-variantut310--------
    rs39146761,2
    		--178957688(-) ATATAA/GTAACA 2 -- nc-transcript-variantut310--------
    rs40961261,2
    		--178957773(-) GTCACA/GGGCCA 2 -- ut31 nc-transcript-variant0--------
    rs39765071,2
    		C,F,A,H,--178957783(-) AGTAAG/ATGCAG 2 -- ut31 nc-transcript-variant15Minor allele frequency- A:0.21NA EA NS WA EU 1375
    rs1845505951,2
    		C,F,--178957810(+) AACTGT/CCAATG 3 /T /A mis11Minor allele frequency- C:0.01EU 569

    HapMap Linkage Disequilibrium report for KCNMB3 (178957530 - 178984838 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KCNMB3: --
    Human Gene Mutation Database (HGMD): KCNMB3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNMB3
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNMB3

    Disorders / Diseases
    for KCNMB3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCNMB3 for disorders           About GeneDecksing

    OMIM gene information: 605222    OMIM disorders: --

    3 diseases for KCNMB3:    About MalaCards
    idiopathic generalized epilepsy    generalized epilepsy    neuronitis

    1 disease from the University of Copenhagen DISEASES database for KCNMB3:
    Idiopathic generalized epilepsy
    Human Genome Epidemiology (HuGE) Navigator: KCNMB3 (1 document)

    Export disorders for KCNMB3 gene to outside databases

    Publications
    for KCNMB3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNMB3 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with KCNMB3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a putative regulatory subunit of a calcium- activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2. (PubMed id 10585773)1, 2, 3 Riazi M.A.... McDermid H.E. (1999)
    2. Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels. (PubMed id 12740608)1, 2 Zeng X.-H.... Lingle C.J. (2003)
    3. Variants of the KCNMB3 regulatory subunit of maxi BK channels affect channel inactivation. (PubMed id 14612589)1, 2 Hu S.... Ali D.W. (2003)
    4. New disguises for an old channel: MaxiK channel beta-subunits. (PubMed id 12136044)1, 2 Orio P.... Latorre R. (2002)
    5. Gating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH termini. (PubMed id 11382809)1, 2 Zeng X.-H.... Lingle C.J. (2001)
    6. Inactivation of BK channels mediated by the NH(2) terminus of the beta3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade. (PubMed id 11382808)1, 2 Lingle C.J.... Xia X.-M. (2001)
    7. hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family. (PubMed id 10828459)1, 2 Behrens R....Pongs O. (2000)
    8. Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit. (PubMed id 10864947)1, 2 Xia X.-M.... Lingle C.J. (2000)
    9. A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. (PubMed id 10792058)1, 2 Meera P.... Toro L. (2000)
    10. Cloning and functional expression of two families of Beta-subunits of the large conductance calcium-activated potassium channel. (PubMed id 10766764)1, 2 Uebele V.N.... Swanson R. (2000)

    External Searches for KCNMB3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing KCNMB3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27094 HGNC: 6287 AceView: KCNMB3 Ensembl:ENSG00000171121 euGenes: HUgn27094
    ECgene: KCNMB3 Kegg: 27094 H-InvDB: KCNMB3

    Other Databases showing KCNMB3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCNMB3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNMB3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCNMB3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCNMB3 gene:
    Search GeneIP for patents involving KCNMB3

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